MX2019010756A - Derivados novedosos de imidazo[4,5-c]quinolina como inhibidores de cinasa 2 rica en repetición de leucina (lrrk2). - Google Patents
Derivados novedosos de imidazo[4,5-c]quinolina como inhibidores de cinasa 2 rica en repetición de leucina (lrrk2).Info
- Publication number
- MX2019010756A MX2019010756A MX2019010756A MX2019010756A MX2019010756A MX 2019010756 A MX2019010756 A MX 2019010756A MX 2019010756 A MX2019010756 A MX 2019010756A MX 2019010756 A MX2019010756 A MX 2019010756A MX 2019010756 A MX2019010756 A MX 2019010756A
- Authority
- MX
- Mexico
- Prior art keywords
- quinoline derivatives
- novel imidazo
- disease
- lrrk2 inhibitors
- lrrk2
- Prior art date
Links
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical class C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 title abstract 2
- 229940124786 LRRK2 inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010024229 Leprosy Diseases 0.000 abstract 1
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 abstract 1
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762469756P | 2017-03-10 | 2017-03-10 | |
| US201862629152P | 2018-02-12 | 2018-02-12 | |
| PCT/IB2018/051439 WO2018163066A1 (en) | 2017-03-10 | 2018-03-06 | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019010756A true MX2019010756A (es) | 2020-01-20 |
Family
ID=61683855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010756A MX2019010756A (es) | 2017-03-10 | 2018-03-06 | Derivados novedosos de imidazo[4,5-c]quinolina como inhibidores de cinasa 2 rica en repetición de leucina (lrrk2). |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11312713B2 (enExample) |
| EP (1) | EP3592741B1 (enExample) |
| JP (1) | JP7219223B2 (enExample) |
| KR (1) | KR102582626B1 (enExample) |
| CN (1) | CN111051304B (enExample) |
| AU (1) | AU2018230236B2 (enExample) |
| BR (1) | BR112019018688A2 (enExample) |
| CA (1) | CA3056030A1 (enExample) |
| IL (1) | IL269214B (enExample) |
| MX (1) | MX2019010756A (enExample) |
| SG (2) | SG10202110112TA (enExample) |
| TW (1) | TWI701246B (enExample) |
| WO (1) | WO2018163066A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12545689B2 (en) | 2020-05-06 | 2026-02-10 | Oncodesign Precision Medicine | Macrocyclic LRRK2 kinase inhibitors |
| CA3195193A1 (en) | 2020-10-29 | 2022-05-05 | Peter H. Fuller | N-linked isoquinoline amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| JP2024512449A (ja) | 2021-03-18 | 2024-03-19 | レ ラボラトワール セルヴィエ | 大環状ｌｒｒｋ２キナーゼ阻害剤 |
| CN119546607A (zh) * | 2022-05-12 | 2025-02-28 | 因特来治疗公司 | Lrrk2抑制剂 |
| AU2023269638A1 (en) * | 2022-05-12 | 2024-11-14 | Interline Therapeutics, Inc. | Lrrk2 inhibitors |
| CN115728413A (zh) * | 2022-11-09 | 2023-03-03 | 内蒙古帕默康创医疗仪器有限公司 | 舍曲林血药浓度的定量分析方法 |
| CN116879450A (zh) * | 2023-07-25 | 2023-10-13 | 江苏汉邦科技股份有限公司 | 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法 |
| CN118440041B (zh) * | 2024-07-02 | 2024-09-27 | 苏州凯瑞医药科技有限公司 | 一种手性4-氨基-3-羟基四氢吡喃的制备方法 |
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| DE3438830A1 (de) | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
| CA1335996C (en) * | 1988-02-16 | 1995-06-20 | Susumu Takada | 2-substituted carbonylimidazo¬4,5-c|quinolines |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| AU1537292A (en) | 1991-04-16 | 1992-11-17 | Nippon Shinyaku Co. Ltd. | Method of manufacturing solid dispersion |
| US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| JP3265680B2 (ja) | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
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| DE19504832A1 (de) | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
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| IL151378A0 (en) | 2000-02-24 | 2003-04-10 | Univ Washington | Humanized antibodies that sequester amyloid beta peptide |
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| BRPI0507374A (pt) | 2004-02-02 | 2007-07-10 | Pfizer Prod Inc | moduladores do receptor de histamina-3 |
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| JP2015531394A (ja) | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | ピロロ［２，３−ｄ］ピリミジントロポミオシン関連キナーゼ阻害剤 |
| WO2014060113A1 (en) * | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Novel kinase inhibitors |
| ITTO20130694A1 (it) * | 2013-08-14 | 2015-02-15 | Umbra Meccanotecnica | Giunto washpipe per un impianto di perforazione petrolifera |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
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| CN108137586B (zh) * | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
| KR20190003997A (ko) | 2016-06-01 | 2019-01-10 | 해롤드 리차드 헬스트롬 | 부교감 신경제와 항교감 신경제를 이용한 안구 건조증의 치료 |
| WO2018163030A1 (en) * | 2017-03-10 | 2018-09-13 | Pfizer Inc. | Cyclic substituted imidazo[4,5-c]quinoline derivatives |
-
2018
- 2018-03-06 WO PCT/IB2018/051439 patent/WO2018163066A1/en not_active Ceased
- 2018-03-06 CA CA3056030A patent/CA3056030A1/en active Pending
- 2018-03-06 MX MX2019010756A patent/MX2019010756A/es unknown
- 2018-03-06 EP EP18711703.1A patent/EP3592741B1/en active Active
- 2018-03-06 AU AU2018230236A patent/AU2018230236B2/en active Active
- 2018-03-06 SG SG10202110112T patent/SG10202110112TA/en unknown
- 2018-03-06 KR KR1020197029735A patent/KR102582626B1/ko active Active
- 2018-03-06 SG SG11201908322W patent/SG11201908322WA/en unknown
- 2018-03-06 CN CN201880029989.5A patent/CN111051304B/zh active Active
- 2018-03-06 BR BR112019018688A patent/BR112019018688A2/pt not_active Application Discontinuation
- 2018-03-06 US US16/492,558 patent/US11312713B2/en active Active
- 2018-03-06 JP JP2019549462A patent/JP7219223B2/ja active Active
- 2018-03-07 TW TW107107734A patent/TWI701246B/zh active
-
2019
- 2019-09-09 IL IL269214A patent/IL269214B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202110112TA (en) | 2021-10-28 |
| AU2018230236A1 (en) | 2019-10-31 |
| US20210355117A1 (en) | 2021-11-18 |
| RU2019131727A (ru) | 2021-04-12 |
| EP3592741B1 (en) | 2023-02-15 |
| US11312713B2 (en) | 2022-04-26 |
| IL269214B (en) | 2022-03-01 |
| TWI701246B (zh) | 2020-08-11 |
| CN111051304B (zh) | 2022-12-27 |
| AU2018230236B2 (en) | 2022-05-19 |
| IL269214A (en) | 2019-11-28 |
| NZ757971A (en) | 2024-12-20 |
| WO2018163066A1 (en) | 2018-09-13 |
| CN111051304A (zh) | 2020-04-21 |
| KR20190138793A (ko) | 2019-12-16 |
| KR102582626B1 (ko) | 2023-09-22 |
| EP3592741A1 (en) | 2020-01-15 |
| JP2020510046A (ja) | 2020-04-02 |
| SG11201908322WA (en) | 2019-10-30 |
| TW201900642A (zh) | 2019-01-01 |
| JP7219223B2 (ja) | 2023-02-07 |
| RU2019131727A3 (enExample) | 2021-04-26 |
| CA3056030A1 (en) | 2018-09-13 |
| BR112019018688A2 (pt) | 2020-04-07 |
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