AU2018230236B2 - Novel imidazo[4,5-c]quinoline derivatives as LRRK2 inhibitors - Google Patents

Novel imidazo[4,5-c]quinoline derivatives as LRRK2 inhibitors Download PDF

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Publication number
AU2018230236B2
AU2018230236B2 AU2018230236A AU2018230236A AU2018230236B2 AU 2018230236 B2 AU2018230236 B2 AU 2018230236B2 AU 2018230236 A AU2018230236 A AU 2018230236A AU 2018230236 A AU2018230236 A AU 2018230236A AU 2018230236 B2 AU2018230236 B2 AU 2018230236B2
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Prior art keywords
methyl
imidazo
quinoline
chloro
pyran
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AU2018230236A1 (en
Inventor
Michael Aaron Brodney
Thomas Allen Chappie
Jinshan Michael Chen
Jotham Wadsworth Coe
Karen Jean Coffman
Paul Galatsis
Michelle Renee GARNSEY
Christopher John Helal
Jaclyn Louise HENDERSON
Bethany Lyn KORMOS
Ravi G. Kurumbail
Luis Angel MARTINEZ-ALSINA
Martin Youngjin Pettersson
Matthew Richard Reese
Colin Richard ROSE
Antonia Friederike STEPAN
Patrick Robert Verhoest
Travis T. Wager
Joseph Scott Warmus
Yuan Zhang
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Pfizer Corp SRL
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Pfizer Corp Belgium
Pfizer Corp SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2018230236A 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as LRRK2 inhibitors Active AU2018230236B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762469756P 2017-03-10 2017-03-10
US62/469,756 2017-03-10
US201862629152P 2018-02-12 2018-02-12
US62/629,152 2018-02-12
PCT/IB2018/051439 WO2018163066A1 (en) 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors

Publications (2)

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AU2018230236A1 AU2018230236A1 (en) 2019-10-31
AU2018230236B2 true AU2018230236B2 (en) 2022-05-19

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AU2018230236A Active AU2018230236B2 (en) 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as LRRK2 inhibitors

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US (1) US11312713B2 (enExample)
EP (1) EP3592741B1 (enExample)
JP (1) JP7219223B2 (enExample)
KR (1) KR102582626B1 (enExample)
CN (1) CN111051304B (enExample)
AU (1) AU2018230236B2 (enExample)
BR (1) BR112019018688A2 (enExample)
CA (1) CA3056030A1 (enExample)
IL (1) IL269214B (enExample)
MX (1) MX2019010756A (enExample)
SG (2) SG11201908322WA (enExample)
TW (1) TWI701246B (enExample)
WO (1) WO2018163066A1 (enExample)

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PE20230612A1 (es) 2020-05-06 2023-04-13 Servier Lab Nuevos inhibidores macrociclicos de la quinasa de lrrk2
JP2023549682A (ja) 2020-10-29 2023-11-29 メルク・シャープ・アンド・ドーム・エルエルシー Ｌｒｒｋ２阻害薬としてのｎ－結合イソキノリンアミド、医薬組成物及びその使用
AU2022239815A1 (en) 2021-03-18 2023-09-21 Les Laboratoires Servier Macrocyclic lrrk2 kinase inhibitors
CA3256816A1 (en) * 2022-05-12 2023-11-16 Interline Therapeutics, Inc. LRRK2 INHIBITORS
JP2025517688A (ja) * 2022-05-12 2025-06-10 インターライン セラピューティクス インコーポレイティド Ｌｒｒｋ２阻害剤
CN115728413A (zh) * 2022-11-09 2023-03-03 内蒙古帕默康创医疗仪器有限公司 舍曲林血药浓度的定量分析方法
CN116879450A (zh) * 2023-07-25 2023-10-13 江苏汉邦科技股份有限公司 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法
CN118440041B (zh) * 2024-07-02 2024-09-27 苏州凯瑞医药科技有限公司 一种手性4-氨基-3-羟基四氢吡喃的制备方法

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WO2005054238A1 (en) * 2003-11-21 2005-06-16 Novartis Ag 1h-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases
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Also Published As

Publication number Publication date
KR20190138793A (ko) 2019-12-16
CN111051304B (zh) 2022-12-27
SG10202110112TA (en) 2021-10-28
TWI701246B (zh) 2020-08-11
MX2019010756A (es) 2020-01-20
CA3056030A1 (en) 2018-09-13
US11312713B2 (en) 2022-04-26
NZ757971A (en) 2024-12-20
WO2018163066A1 (en) 2018-09-13
JP2020510046A (ja) 2020-04-02
IL269214B (en) 2022-03-01
SG11201908322WA (en) 2019-10-30
KR102582626B1 (ko) 2023-09-22
EP3592741B1 (en) 2023-02-15
JP7219223B2 (ja) 2023-02-07
AU2018230236A1 (en) 2019-10-31
EP3592741A1 (en) 2020-01-15
RU2019131727A (ru) 2021-04-12
US20210355117A1 (en) 2021-11-18
TW201900642A (zh) 2019-01-01
RU2019131727A3 (enExample) 2021-04-26
CN111051304A (zh) 2020-04-21
BR112019018688A2 (pt) 2020-04-07
IL269214A (en) 2019-11-28

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