CN1107066C - 二氮杂－螺[3,5]壬烷衍生物 - Google Patents

二氮杂－螺[3,5]壬烷衍生物 Download PDF

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Publication number
CN1107066C
CN1107066C CN99108373A CN99108373A CN1107066C CN 1107066 C CN1107066 C CN 1107066C CN 99108373 A CN99108373 A CN 99108373A CN 99108373 A CN99108373 A CN 99108373A CN 1107066 C CN1107066 C CN 1107066C
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CN
China
Prior art keywords
spiro
phenyl
diaza
nonan
compound
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Expired - Fee Related
Application number
CN99108373A
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English (en)
Chinese (zh)
Other versions
CN1242366A (zh
Inventor
G·阿达姆
A·西素拉
F·杰克
S·科尔泽斯基
S·罗维尔
J·威切曼
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1242366A publication Critical patent/CN1242366A/zh
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Publication of CN1107066C publication Critical patent/CN1107066C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
CN99108373A 1998-06-12 1999-06-11 二氮杂－螺[3,5]壬烷衍生物 Expired - Fee Related CN1107066C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110804.6 1998-06-12
EP98110804 1998-06-12

Publications (2)

Publication Number Publication Date
CN1242366A CN1242366A (zh) 2000-01-26
CN1107066C true CN1107066C (zh) 2003-04-30

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99108373A Expired - Fee Related CN1107066C (zh) 1998-06-12 1999-06-11 二氮杂－螺[3,5]壬烷衍生物

Country Status (28)

Country Link
US (1) US6113527A (Direct)
EP (1) EP0970957B1 (Direct)
JP (1) JP3286268B2 (Direct)
KR (1) KR100344732B1 (Direct)
CN (1) CN1107066C (Direct)
AR (1) AR019859A1 (Direct)
AT (1) ATE204279T1 (Direct)
AU (1) AU743983B2 (Direct)
BR (1) BR9902651A (Direct)
CA (1) CA2274202A1 (Direct)
DE (1) DE69900220T2 (Direct)
DK (1) DK0970957T3 (Direct)
ES (1) ES2162503T3 (Direct)
HR (1) HRP990188A2 (Direct)
HU (1) HU220894B1 (Direct)
ID (1) ID23304A (Direct)
IL (1) IL130377A0 (Direct)
MA (1) MA26644A1 (Direct)
NO (1) NO312590B1 (Direct)
NZ (1) NZ336189A (Direct)
PE (1) PE20000548A1 (Direct)
PL (1) PL333695A1 (Direct)
PT (1) PT970957E (Direct)
SG (1) SG79259A1 (Direct)
SI (1) SI0970957T1 (Direct)
TR (1) TR199901381A2 (Direct)
YU (1) YU26499A (Direct)
ZA (1) ZA993852B (Direct)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406629A1 (en) * 2001-07-02 2004-04-14 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP4056977B2 (ja) * 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
BR0312414A (pt) 2002-07-05 2005-05-10 Targacept Inc Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos
EP1601674B1 (en) * 2002-09-09 2012-08-08 Janssen Pharmaceutica NV Hydroxyalkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
WO2005060947A2 (en) * 2003-12-19 2005-07-07 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
EP1784184A2 (en) * 2004-08-20 2007-05-16 Targacept, Inc. The use of n-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
US8703948B2 (en) * 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
MX2009011006A (es) * 2007-04-09 2009-11-02 Janssen Pharmaceutica Nv Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
EP4452416A1 (en) * 2021-12-22 2024-10-30 The Regents Of The University Of California Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOLOGICAL CHEMISTRY (273.3) 1998-01-16 R. K.REINSCHEID ET AL *
JOURNAL OF BIOLOGICAL CHEMISTRY (273.3) 1998-01-16 R. K.REINSCHEID ET AL;NATURE(377) 1995-10-12 D.JULIUS;TETRAHEDYON(25.18) 1969-01-01 M.S. MANHAS ET AL *
NATURE(377) 1995-10-12 D.JULIUS *
TETRAHEDYON(25.18) 1969-01-01 M.S. MANHAS ET AL *

Also Published As

Publication number Publication date
HU220894B1 (en) 2002-06-29
IL130377A0 (en) 2000-06-01
YU26499A (sh) 2002-09-19
BR9902651A (pt) 2000-05-16
NO992873D0 (no) 1999-06-11
EP0970957B1 (en) 2001-08-16
AU743983B2 (en) 2002-02-14
NO992873L (no) 1999-12-13
HRP990188A2 (en) 2000-02-29
NO312590B1 (no) 2002-06-03
TR199901381A3 (tr) 2000-01-21
JP3286268B2 (ja) 2002-05-27
SI0970957T1 (Direct) 2001-12-31
ZA993852B (en) 1999-12-13
KR100344732B1 (ko) 2002-07-19
ES2162503T3 (es) 2001-12-16
PE20000548A1 (es) 2000-07-15
US6113527A (en) 2000-09-05
PL333695A1 (en) 1999-12-20
CA2274202A1 (en) 1999-12-12
HU9901911D0 (en) 1999-08-30
PT970957E (pt) 2002-02-28
DK0970957T3 (da) 2001-12-03
AR019859A1 (es) 2002-03-20
JP2000053679A (ja) 2000-02-22
DE69900220D1 (de) 2001-09-20
ID23304A (id) 2000-04-05
HUP9901911A1 (hu) 2000-05-28
DE69900220T2 (de) 2002-05-08
MA26644A1 (fr) 2004-12-20
TR199901381A2 (xx) 2000-01-21
ATE204279T1 (de) 2001-09-15
KR20000006060A (ko) 2000-01-25
CN1242366A (zh) 2000-01-26
EP0970957A1 (en) 2000-01-12
AU3498799A (en) 1999-12-23
SG79259A1 (en) 2001-03-20
NZ336189A (en) 2000-10-27

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