CN110691795A - 包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 - Google Patents

包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 Download PDF

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Publication number
CN110691795A
CN110691795A CN201880036532.7A CN201880036532A CN110691795A CN 110691795 A CN110691795 A CN 110691795A CN 201880036532 A CN201880036532 A CN 201880036532A CN 110691795 A CN110691795 A CN 110691795A
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antibody
antagonist
agonist
cancer
lag
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A·J·科曼
N·隆伯格
M·J·塞尔比
J·杰克逊
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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CN201880036532.7A 2017-05-30 2018-05-30 包含抗-lag3抗体、pd-1途径抑制剂和免疫治疗剂组合的组合物 Pending CN110691795A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762512618P 2017-05-30 2017-05-30
US62/512,618 2017-05-30
US201762513812P 2017-06-01 2017-06-01
US62/513,812 2017-06-01
PCT/US2018/035125 WO2018222711A2 (en) 2017-05-30 2018-05-30 Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent

Publications (1)

Publication Number Publication Date
CN110691795A true CN110691795A (zh) 2020-01-14

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US (3) US20210340250A1 (enExample)
EP (2) EP4245375A3 (enExample)
JP (2) JP2020522495A (enExample)
KR (1) KR20200010500A (enExample)
CN (1) CN110691795A (enExample)
AU (2) AU2018277559A1 (enExample)
BR (1) BR112019018759A2 (enExample)
CA (1) CA3060989A1 (enExample)
IL (1) IL269090A (enExample)
MX (1) MX2019012038A (enExample)
WO (1) WO2018222711A2 (enExample)

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CN111808192A (zh) * 2020-06-05 2020-10-23 北京天广实生物技术股份有限公司 结合lag3的抗体及其用途
CN113616788A (zh) * 2020-05-08 2021-11-09 勤浩医药（苏州）有限公司 抗lag-3抗体与shp-2抑制剂联合治疗肿瘤的用途
CN115845052A (zh) * 2022-12-28 2023-03-28 广州誉衡生物科技有限公司 一种药物组合物和药物制剂及其在治疗结肠癌中的应用
CN116059341A (zh) * 2021-07-23 2023-05-05 中山康方生物医药有限公司 药物组合物及用途
CN116925236A (zh) * 2023-05-12 2023-10-24 上海恩凯细胞技术有限公司 嵌合转换受体及其应用
WO2025195358A1 (zh) * 2024-03-19 2025-09-25 江苏恒瑞医药股份有限公司 Pd-1结合蛋白及医药用途

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KR20250120305A (ko) 2022-12-14 2025-08-08 아스텔라스 파마 유럽 비.브이. Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법
CN115869399B (zh) * 2022-12-28 2024-01-12 广州誉衡生物科技有限公司 一种药物组合物和药物制剂及其在治疗非小细胞肺癌中的应用
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TW202509071A (zh) 2023-05-12 2025-03-01 丹麥商珍美寶股份有限公司 能夠與ｏｘ４０結合之抗體、其變異體及其用途
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