CN110418787A - 一种吲哚乙酸类衍生物及其制备方法和医药用途 - Google Patents

一种吲哚乙酸类衍生物及其制备方法和医药用途 Download PDF

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CN110418787A
CN110418787A CN201880016571.0A CN201880016571A CN110418787A CN 110418787 A CN110418787 A CN 110418787A CN 201880016571 A CN201880016571 A CN 201880016571A CN 110418787 A CN110418787 A CN 110418787A
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pharmaceutically acceptable
compound
mesomer
enantiomter
diastereoisomer
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CN110418787B (zh
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刘安
程锦堂
郭丛
章军
陈畅
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Institute of Materia Medica of CAMS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)

Abstract

本发明涉及一种吲哚乙酸类衍生物及其制备方法和医药用途。特别地，本发明涉及通式(I)所示的化合物、其制备方法及含有其的药物组合物，及其作为止咳剂在治疗咳嗽等疾病中的用途。其中通式(I)中的各取代基的定义与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201880016571.0A 2017-06-07 2018-05-15 一种吲哚乙酸类衍生物及其制备方法和医药用途 Active CN110418787B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017104217764 2017-06-07
CN201710421776 2017-06-07
PCT/CN2018/086774 WO2018223819A1 (zh) 2017-06-07 2018-05-15 一种吲哚乙酸类衍生物及其制备方法和医药用途

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CN110418787A true CN110418787A (zh) 2019-11-05
CN110418787B CN110418787B (zh) 2022-09-13

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US (1) US11008360B2 (zh)
EP (1) EP3636642A4 (zh)
JP (1) JP7152479B2 (zh)
CN (1) CN110418787B (zh)
WO (1) WO2018223819A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110922440B (zh) * 2019-11-01 2023-01-17 天津中医药大学 吲哚氮苷类化合物及提取方法及在制备防治神经系统疾病药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1933830A (zh) * 2004-01-15 2007-03-21 史密丝克莱恩比彻姆公司 吲哚衍生物和其作为激酶抑制剂特别是ikk2抑制剂的用途
WO2016100281A1 (en) * 2014-12-15 2016-06-23 Merck Patent Gmbh Indole and azaindoles derivatives and their use in neurodegenerative diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1933830A (zh) * 2004-01-15 2007-03-21 史密丝克莱恩比彻姆公司 吲哚衍生物和其作为激酶抑制剂特别是ikk2抑制剂的用途
WO2016100281A1 (en) * 2014-12-15 2016-06-23 Merck Patent Gmbh Indole and azaindoles derivatives and their use in neurodegenerative diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KARIN LJUNG等: "Developmental Regulation of Indole-3-Acetic Acid Turnover in Scots Pine Seedlings", 《PLANT PHYSIOLOGY》 *
KENJI KAI等: "Metabolism of indole-3-acetic acid in rice: Identification and characterization of N-b-D-glucopyranosyl indole-3-acetic acid and its conjugates", 《PHYTOCHEMISTRY》 *
MIN-JIA TAN等: "Antitussive Indole Alkaloids from Kopsia hainanensis", 《PLANTA MED》 *

Also Published As

Publication number Publication date
EP3636642A4 (en) 2021-03-24
WO2018223819A1 (zh) 2018-12-13
US11008360B2 (en) 2021-05-18
US20200095271A1 (en) 2020-03-26
EP3636642A1 (en) 2020-04-15
EP3636642A8 (en) 2020-07-01
JP2020522579A (ja) 2020-07-30
CN110418787B (zh) 2022-09-13
JP7152479B2 (ja) 2022-10-12

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