CN110366549A - 作为白介素-1活性抑制剂的化合物 - Google Patents
作为白介素-1活性抑制剂的化合物 Download PDFInfo
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- CN110366549A CN110366549A CN201880014694.0A CN201880014694A CN110366549A CN 110366549 A CN110366549 A CN 110366549A CN 201880014694 A CN201880014694 A CN 201880014694A CN 110366549 A CN110366549 A CN 110366549A
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- Prior art keywords
- alkyl
- halogen
- naphthenic base
- heterocycle
- heteroaryl
- Prior art date
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449431P | 2017-01-23 | 2017-01-23 | |
| US62/449,431 | 2017-01-23 | ||
| US201762492813P | 2017-05-01 | 2017-05-01 | |
| US62/492,813 | 2017-05-01 | ||
| PCT/US2018/014728 WO2018136890A1 (en) | 2017-01-23 | 2018-01-22 | Chemical compounds as inhibitors of interleukin-1 activity |
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| CN114516878A (zh) * | 2020-11-20 | 2022-05-20 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
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| WO2023116812A1 (zh) * | 2021-12-22 | 2023-06-29 | 瑞石生物医药有限公司 | 一种磺酰脲类化合物 |
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