CN110312792B - 热稳定的Cas9核酸酶 - Google Patents

热稳定的Cas9核酸酶 Download PDF

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Publication number
CN110312792B
CN110312792B CN201680092098.5A CN201680092098A CN110312792B CN 110312792 B CN110312792 B CN 110312792B CN 201680092098 A CN201680092098 A CN 201680092098A CN 110312792 B CN110312792 B CN 110312792B
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protein
nucleic acid
double
target nucleic
sequence
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CN110312792A (zh
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约翰·万德奥斯特
理查德·范克拉嫩堡
艾勒克·芬纳·博斯马
扬尼斯·莫加科斯
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Stichting voor de Technische Wetenschappen STW
Wageningen Universiteit
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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CN201680092098.5A 2016-12-14 2016-12-14 热稳定的Cas9核酸酶 Active CN110312792B (zh)

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Application Number Priority Date Filing Date Title
PCT/EP2016/081077 WO2018108272A1 (en) 2016-12-14 2016-12-14 Thermostable cas9 nucleases

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CN110312792B true CN110312792B (zh) 2024-04-09

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CN201780086541.2A Active CN110352241B (zh) 2016-12-14 2017-08-16 热稳定的Cas9核酸酶
CN201780086540.8A Active CN110382693B (zh) 2016-12-14 2017-08-16 热稳定的Cas9核酸酶
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CN201780086540.8A Active CN110382693B (zh) 2016-12-14 2017-08-16 热稳定的Cas9核酸酶
CN201780086546.5A Active CN110431229B (zh) 2016-12-14 2017-12-14 热稳定的Cas9核酸酶

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US (5) US11242513B2 (enExample)
EP (4) EP3555275A1 (enExample)
JP (6) JP7182545B2 (enExample)
KR (4) KR102913446B1 (enExample)
CN (4) CN110312792B (enExample)
AU (4) AU2016432443B2 (enExample)
BR (3) BR112019012155A2 (enExample)
CA (4) CA3046824A1 (enExample)
EA (4) EA201991443A1 (enExample)
PH (4) PH12019501344A1 (enExample)
WO (4) WO2018108272A1 (enExample)

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