CN110267962B - Magl抑制剂 - Google Patents

Magl抑制剂 Download PDF

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Publication number
CN110267962B
CN110267962B CN201780083651.3A CN201780083651A CN110267962B CN 110267962 B CN110267962 B CN 110267962B CN 201780083651 A CN201780083651 A CN 201780083651A CN 110267962 B CN110267962 B CN 110267962B
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pharmaceutically acceptable
acceptable salt
formula
solvate
compounds
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CN201780083651.3A
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Chinese (zh)
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CN110267962A (zh
Inventor
谢丽尔·A·格莱斯
丹尼尔·J·布扎德
迈克尔·B·沙格哈飞
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H Lundbeck AS
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H Lundbeck AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201780083651.3A 2016-11-16 2017-11-15 Magl抑制剂 Active CN110267962B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423102P 2016-11-16 2016-11-16
US62/423,102 2016-11-16
PCT/US2017/061870 WO2018093949A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (2)

Publication Number Publication Date
CN110267962A CN110267962A (zh) 2019-09-20
CN110267962B true CN110267962B (zh) 2022-04-01

Family

ID=62145825

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780083651.3A Active CN110267962B (zh) 2016-11-16 2017-11-15 Magl抑制剂

Country Status (27)

Country Link
US (2) US11059822B2 (enExample)
EP (1) EP3541820B1 (enExample)
JP (1) JP7042468B2 (enExample)
KR (1) KR20190080935A (enExample)
CN (1) CN110267962B (enExample)
AU (1) AU2017361253B2 (enExample)
BR (1) BR112019009880A2 (enExample)
CA (1) CA3043617A1 (enExample)
CL (1) CL2019001336A1 (enExample)
CO (1) CO2019004945A2 (enExample)
CR (1) CR20190239A (enExample)
DO (1) DOP2019000118A (enExample)
EA (1) EA038150B1 (enExample)
EC (1) ECSP19034535A (enExample)
ES (1) ES2952582T3 (enExample)
IL (1) IL266547B (enExample)
JO (1) JOP20190107A1 (enExample)
MA (1) MA46855A (enExample)
MX (1) MX389627B (enExample)
NI (1) NI201900049A (enExample)
PE (1) PE20191145A1 (enExample)
PH (1) PH12019501079A1 (enExample)
RU (1) RU2019115784A (enExample)
TN (1) TN2019000149A1 (enExample)
UA (1) UA125523C2 (enExample)
WO (1) WO2018093949A1 (enExample)
ZA (1) ZA201903099B (enExample)

Families Citing this family (16)

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ES2861648T3 (es) * 2016-05-12 2021-10-06 Lundbeck La Jolla Research Center Inc Compuestos de espirociclo y procedimientos de fabricación y uso de los mismos
BR112019009992A2 (pt) 2016-11-16 2019-08-27 Abide Therapeutics Inc formulações farmacêuticas
CA3043610A1 (en) 2016-11-16 2018-05-24 Abide Therapeutics, Inc. Crystalline forms of a magl inhibitor
JOP20190105A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
ES2940111T3 (es) 2017-05-23 2023-05-03 H Lundbeck As Inhibidores de MAGL de pirazol
CR20200088A (es) 2017-08-29 2020-04-08 Lundbeck La Jolla Research Center Inc Compuestos espirocíclicos y sus métodos de preparación y uso
MA50041A (fr) 2017-08-29 2020-07-08 Lundbeck La Jolla Research Center Inc Composés spirocycliques et procédés de préparation et d'utilisation de ceux-ci
JP2021531287A (ja) * 2018-07-19 2021-11-18 ファイザー・インク Ｍａｇｌ阻害剤としての複素環式スピロ化合物
PE20211089A1 (es) 2018-08-13 2021-06-14 Hoffmann La Roche Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa
BR112021025516A2 (pt) 2020-04-21 2022-11-01 H Lundbeck As Processos para a fabricação de 4-(2-(pirrolidin-1-il)-4-(trifluorometil)benzil)piperazina-1-carboxilato de 1,1,1,3,3,3-hexafluoropropan-2-ila e da forma 2 do sal monocloridrato do mesmo
US11434222B2 (en) 2020-11-13 2022-09-06 H. Lundbeck A/S MAGL inhibitors
MX2024008337A (es) 2021-12-29 2024-07-30 Psy Therapeutics Inc Inhibicion de la monoacilglicerol lipasa (magl).
CN119137114A (zh) 2022-05-04 2024-12-13 H.隆德贝克有限公司 作为单酰基甘油脂肪酶抑制剂的(s)-1-(哒嗪-3-基氨基甲酰基)-6-氮杂螺[2.5]辛烷-6-甲酸1,1,1,3,3,3-六氟丙-2-酯的结晶形式
WO2024168426A1 (en) 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof

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WO2016149401A2 (en) * 2015-03-18 2016-09-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
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JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
MA50041A (fr) 2017-08-29 2020-07-08 Lundbeck La Jolla Research Center Inc Composés spirocycliques et procédés de préparation et d'utilisation de ceux-ci
CR20200088A (es) 2017-08-29 2020-04-08 Lundbeck La Jolla Research Center Inc Compuestos espirocíclicos y sus métodos de preparación y uso
US11434222B2 (en) 2020-11-13 2022-09-06 H. Lundbeck A/S MAGL inhibitors

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CN105517547A (zh) * 2013-07-03 2016-04-20 阿比德治疗公司 吡咯并吡咯氨基甲酸酯和相关的有机化合物、药物组合物及其医学用途
WO2016149401A2 (en) * 2015-03-18 2016-09-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
WO2018093946A1 (en) * 2016-11-16 2018-05-24 Abide Therapeutics, Inc. Magl inhibitors

Also Published As

Publication number Publication date
EP3541820A1 (en) 2019-09-25
US11691975B2 (en) 2023-07-04
NI201900049A (es) 2019-10-30
AU2017361253B2 (en) 2021-08-05
UA125523C2 (uk) 2022-04-13
ECSP19034535A (es) 2019-05-31
KR20190080935A (ko) 2019-07-08
US20220135563A1 (en) 2022-05-05
TN2019000149A1 (en) 2020-10-05
CA3043617A1 (en) 2018-05-24
CR20190239A (es) 2019-06-26
MX2019005773A (es) 2019-12-05
WO2018093949A1 (en) 2018-05-24
DOP2019000118A (es) 2019-09-30
RU2019115784A (ru) 2020-12-17
EA038150B1 (ru) 2021-07-14
EP3541820C0 (en) 2023-07-05
US20200291023A1 (en) 2020-09-17
MA46855A (fr) 2021-05-19
EA201991029A1 (ru) 2019-12-30
AU2017361253A1 (en) 2019-05-30
EP3541820A4 (en) 2020-06-10
IL266547A (en) 2019-07-31
JOP20190107A1 (ar) 2019-05-09
ZA201903099B (en) 2021-01-27
MX389627B (es) 2025-03-20
PE20191145A1 (es) 2019-09-02
CN110267962A (zh) 2019-09-20
PH12019501079A1 (en) 2019-08-19
IL266547B (en) 2022-06-01
US11059822B2 (en) 2021-07-13
CO2019004945A2 (es) 2019-05-21
JP2020500178A (ja) 2020-01-09
RU2019115784A3 (enExample) 2021-03-12
EP3541820B1 (en) 2023-07-05
BR112019009880A2 (pt) 2019-08-13
CL2019001336A1 (es) 2019-10-04
JP7042468B2 (ja) 2022-03-28
NZ753471A (en) 2021-01-29
ES2952582T3 (es) 2023-11-02

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