CN110123774A - 达比加群酯的口服药物组合物 - Google Patents

达比加群酯的口服药物组合物 Download PDF

Info

Publication number
CN110123774A
CN110123774A CN201910336600.8A CN201910336600A CN110123774A CN 110123774 A CN110123774 A CN 110123774A CN 201910336600 A CN201910336600 A CN 201910336600A CN 110123774 A CN110123774 A CN 110123774A
Authority
CN
China
Prior art keywords
particle
pharmaceutically acceptable
type
organic acid
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910336600.8A
Other languages
English (en)
Chinese (zh)
Inventor
普拉蒂巴·S·皮尔冈卡尔
马哈鲁赫·T·鲁斯托姆吉
阿尼尔库马尔·S·甘迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tova Pharmaceutical Europe Co ltd
Original Assignee
Ethiway Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47739283&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN110123774(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethiway Pharmaceutical Co Ltd filed Critical Ethiway Pharmaceutical Co Ltd
Publication of CN110123774A publication Critical patent/CN110123774A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201910336600.8A 2012-02-21 2013-02-21 达比加群酯的口服药物组合物 Pending CN110123774A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN461/MUM/2012 2012-02-21
IN461MU2012 2012-02-21
CN201380010066.2A CN104114158A (zh) 2012-02-21 2013-02-21 达比加群酯的口服药物组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380010066.2A Division CN104114158A (zh) 2012-02-21 2013-02-21 达比加群酯的口服药物组合物

Publications (1)

Publication Number Publication Date
CN110123774A true CN110123774A (zh) 2019-08-16

Family

ID=47739283

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910336600.8A Pending CN110123774A (zh) 2012-02-21 2013-02-21 达比加群酯的口服药物组合物
CN201380010066.2A Pending CN104114158A (zh) 2012-02-21 2013-02-21 达比加群酯的口服药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380010066.2A Pending CN104114158A (zh) 2012-02-21 2013-02-21 达比加群酯的口服药物组合物

Country Status (27)

Country Link
US (3) US11013729B2 (enExample)
EP (2) EP3858337A3 (enExample)
JP (1) JP6215239B2 (enExample)
KR (1) KR102090242B1 (enExample)
CN (2) CN110123774A (enExample)
AU (1) AU2013224146B2 (enExample)
BR (1) BR112014020474B1 (enExample)
CA (1) CA2864423C (enExample)
CY (1) CY1124678T1 (enExample)
DK (1) DK2817000T3 (enExample)
ES (1) ES2895918T3 (enExample)
HR (1) HRP20211606T1 (enExample)
HU (1) HUE056194T2 (enExample)
IL (1) IL234032B (enExample)
IN (1) IN2014DN06734A (enExample)
JO (1) JO3616B1 (enExample)
LT (1) LT2817000T (enExample)
MX (1) MX368868B (enExample)
NZ (1) NZ628301A (enExample)
PL (1) PL2817000T3 (enExample)
PT (1) PT2817000T (enExample)
RS (1) RS62566B1 (enExample)
RU (1) RU2633482C2 (enExample)
SI (1) SI2817000T1 (enExample)
SM (1) SMT202100608T1 (enExample)
WO (1) WO2013124340A1 (enExample)
ZA (1) ZA201405855B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113577067A (zh) * 2021-06-03 2021-11-02 北京福元医药股份有限公司 一种甲磺酸达比加群酯药物制剂
CN115006363A (zh) * 2022-06-23 2022-09-06 上海信谊万象药业股份有限公司 一种牡蛎碳酸钙咀嚼片及其制备方法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2817000T (pt) 2012-02-21 2021-11-02 Towa Pharmaceutical Europe S L Composições farmacêuticas de dabigatrano etexilato
CN104224754A (zh) * 2013-06-21 2014-12-24 四川海思科制药有限公司 一种达比加群酯药物组合物及其制备方法
CN104414995A (zh) * 2013-09-04 2015-03-18 天津汉瑞药业有限公司 甲磺酸达比加群酯的药用组合物
EP2853260A1 (en) * 2013-09-27 2015-04-01 ratiopharm GmbH Pharmaceutical preparation comprising dabigatran etexilate bismesylate
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CN104784147B (zh) * 2014-01-20 2018-01-23 成都苑东生物制药股份有限公司 一种甲磺酸达比加群酯胶囊药物组合物及其制备方法
WO2015113324A1 (zh) * 2014-01-30 2015-08-06 杭州领业医药科技有限公司 达比加群酯及其盐的投药制剂及其制备方法
CN104922092A (zh) * 2014-03-19 2015-09-23 陕西天森药物研究开发有限公司 一种通过包裹法制备的达比加群酯或其盐和水合物的药物组合
IN2014MU01042A (enExample) 2014-03-26 2015-10-02 Cadila Healthcare Ltd
CN104095830A (zh) * 2014-05-22 2014-10-15 万特制药(海南)有限公司 一种甲磺酸盐达比加群酯胶囊的制备方法
CN104825422B (zh) * 2014-09-29 2017-12-12 普济生物科技（台州）有限公司 含达比加群酯甲磺酸盐的药物组合物及其制备方法
CN105560206A (zh) * 2014-10-13 2016-05-11 重庆圣华曦药业股份有限公司 一种达比加群酯胶囊的制备
US10675276B2 (en) * 2014-11-03 2020-06-09 Hangzhou Solipharma Co., Ltd. Dosing preparation of dabigatran etexilate or a salt thereof and a preparation method thereof
WO2016107605A1 (zh) 2014-12-31 2016-07-07 昆明积大制药股份有限公司 药物组合物及其制备方法
WO2017103945A1 (en) * 2015-12-15 2017-06-22 Strides Shasun Limited Pharmaceutical compositions
CN106890148A (zh) * 2015-12-21 2017-06-27 青岛黄海制药有限责任公司 一种达比加群酯片剂及其制备
WO2017111637A1 (en) 2015-12-23 2017-06-29 Zaklady Farmaceutyczne Polpharma Sa Pharmaceutical composition comprising dabigatran or a pharmaceutically acceptable salt thereof
JP2018184375A (ja) * 2017-04-27 2018-11-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ダビガトランエテキシラート又は医薬的に許容されるその塩を含む錠剤及びその製造方法
TR201706848A2 (tr) * 2017-05-10 2018-11-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dabigatran eteksi̇lat i̇çeren kati oral farmasöti̇k kompozi̇syonlar
WO2019004980A2 (en) * 2017-05-10 2019-01-03 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi SOLID ORAL PHARMACEUTICAL COMPOSITIONS OF DABIGATRAN DEXILATE
TR201722353A2 (tr) * 2017-12-27 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dabi̇gatran eteksi̇lat i̇çeren oral uygulama i̇çi̇n farmasöti̇k formülasyon
TR201722323A2 (tr) 2017-12-27 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dabi̇gatranin oral farmasöti̇k kompozi̇syonlari
TR201722630A2 (enExample) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
CN110339193B (zh) 2018-04-04 2022-04-29 上海汉都医药科技有限公司 含达比加群酯的药物组合物及其制备方法
WO2020032885A2 (en) 2018-05-04 2020-02-13 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Capsule-in-capsule compositions of dabigatran etexilate
TR201905308A2 (tr) * 2019-04-09 2020-10-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A capsule formulation of dabigatran etexilate
WO2024175037A1 (zh) * 2023-02-21 2024-08-29 广州玻思韬控释药业有限公司 达比加群酯或其药物可接受的盐的微丸

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101632668A (zh) * 2002-03-07 2010-01-27 贝林格尔英格海姆法玛两合公司 口服药物组合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
JPH04103525A (ja) * 1990-08-22 1992-04-06 Sanwa Kagaku Kenkyusho Co Ltd 難水溶性薬物の持続性製剤化方法
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
AU7375598A (en) 1997-05-09 1998-11-27 Sage Pharmaceuticals, Inc. Stable oral pharmaceutical dosage forms
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
KR100610131B1 (ko) * 2000-09-06 2006-08-09 다나베 세이야꾸 가부시키가이샤 경구 투여용 제제
CA2437754C (en) 2001-02-15 2010-05-18 Tanabe Seiyaku Co., Ltd. Tablets quickly disintegrated in oral cavity
ATE540943T1 (de) * 2002-03-07 2012-01-15 Boehringer Ingelheim Pharma 3-ä(2-ää4-(hexyloxycarbonylamino-imino-methyl)- phenylaminoümethylü-1-methyl-1h-benzimidazol-5- carbonyl)-pyridin-2-yl-aminoü-propionsäure- ethylester methansulfonat
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10337697A1 (de) 2003-08-16 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tablette enthaltend 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenyl-amino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester oder dessen Salze
DE10339862A1 (de) 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
AU2004289222B2 (en) 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
JP2008501702A (ja) 2004-06-02 2008-01-24 ファーマサイクリックス，インコーポレイティド 第ＶＩＩａ因子阻害剤
CN101031570B (zh) 2004-07-30 2012-09-05 梅特希尔基因公司 Vegf受体和hgf受体信号的抑制剂
JP2008534681A (ja) 2006-02-09 2008-08-28 テバ ファーマシューティカル インダストリーズ リミティド ジピリダモール持続放出製剤及びそれを調製のための方法
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
CA2716642C (en) 2008-03-28 2017-02-28 Boehringer Ingelheim International Gmbh Method for manufacturing acid pellets
RU2010143901A (ru) * 2008-03-28 2012-05-10 Бёрингер Ингельхайм Интернациональ Гмбх (De) Способ получения композиций дабигатрана для перорального введения
RU2529798C2 (ru) 2008-07-14 2014-09-27 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения лекарственных соединений, содержащих дабигатран
EA201201202A1 (ru) * 2010-03-01 2013-04-30 Рациофарм Гмбх Пероральная фармацевтическая композиция, содержащая этексилат дабигатрана
US20130177652A1 (en) * 2010-07-01 2013-07-11 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising dabigatran etexilate and its pharmaceutically acceptable salts
US20120301541A1 (en) 2011-05-24 2012-11-29 Haronsky Elina Compressed core for pharmaceutical composition
PT2817000T (pt) 2012-02-21 2021-11-02 Towa Pharmaceutical Europe S L Composições farmacêuticas de dabigatrano etexilato
CN102793699B (zh) 2012-08-06 2014-06-04 严轶东 一种含有达比加群酯的药用组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101632668A (zh) * 2002-03-07 2010-01-27 贝林格尔英格海姆法玛两合公司 口服药物组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
山东省卫生厅: "《山东省各级中医医院工作人员三基训练标准》", 30 June 1998 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113577067A (zh) * 2021-06-03 2021-11-02 北京福元医药股份有限公司 一种甲磺酸达比加群酯药物制剂
CN113577067B (zh) * 2021-06-03 2023-08-15 北京福元医药股份有限公司 一种甲磺酸达比加群酯药物制剂
CN115006363A (zh) * 2022-06-23 2022-09-06 上海信谊万象药业股份有限公司 一种牡蛎碳酸钙咀嚼片及其制备方法

Also Published As

Publication number Publication date
MX2014010040A (es) 2014-11-10
AU2013224146A1 (en) 2014-08-28
NZ628301A (en) 2015-07-31
AU2013224146B2 (en) 2017-06-08
IL234032A0 (en) 2014-09-30
JP2015511241A (ja) 2015-04-16
IN2014DN06734A (enExample) 2015-05-22
RS62566B1 (sr) 2021-12-31
DK2817000T3 (da) 2021-10-11
CA2864423A1 (en) 2013-08-29
JO3616B1 (ar) 2020-08-27
HUE056194T2 (hu) 2022-01-28
PL2817000T3 (pl) 2022-03-28
MX368868B (es) 2019-10-11
SI2817000T1 (sl) 2022-02-28
RU2633482C2 (ru) 2017-10-12
HRP20211606T1 (hr) 2022-01-21
BR112014020474A2 (pt) 2020-02-11
WO2013124340A1 (en) 2013-08-29
LT2817000T (lt) 2021-11-10
CN104114158A (zh) 2014-10-22
EP3858337A3 (en) 2021-09-29
BR112014020474B1 (pt) 2022-03-29
HK1203832A1 (en) 2015-11-06
CA2864423C (en) 2021-08-10
JP6215239B2 (ja) 2017-10-18
US20240139168A1 (en) 2024-05-02
KR102090242B1 (ko) 2020-03-18
EP3858337A2 (en) 2021-08-04
EP2817000B1 (en) 2021-08-04
RU2014138036A (ru) 2016-04-20
US11752142B2 (en) 2023-09-12
EP2817000A1 (en) 2014-12-31
CY1124678T1 (el) 2022-07-22
PT2817000T (pt) 2021-11-02
US20150030680A1 (en) 2015-01-29
KR20140135216A (ko) 2014-11-25
US11013729B2 (en) 2021-05-25
US20210244719A1 (en) 2021-08-12
ES2895918T3 (es) 2022-02-23
IL234032B (en) 2020-06-30
SMT202100608T1 (it) 2021-11-12
ZA201405855B (en) 2015-11-25

Similar Documents

Publication Publication Date Title
US11752142B2 (en) Oral pharmaceutical compositions of dabigatran etexilate
CA2844604C (en) Pharmaceutical composition containing ethanediamide derivatives
JP4789806B2 (ja) パントプラゾール多粒子処方
JPWO2008129846A1 (ja) 医薬組成物
IL204706A (en) Matrix-type solid composition containing anacrylic acid-based, sugar, and free toluaphenic acid supplemented with a conditioner
CN105012301B (zh) 代谢型谷氨酸受体5(mglu5)拮抗剂的药物组合物
JP2015522653A (ja) プロトンポンプ阻害剤の医薬組成物
CA2765522A1 (en) Solid pharmaceutical composition of edoxaban having improved solubility
WO2015145462A1 (en) Pharmaceutical compositions of dabigatran
EP2533766B1 (en) Pharmaceutical mini-tablets for sustained release of flecainide acetate
CN103068372A (zh) 代谢型谷氨酸受体5(mglu5)拮抗剂的药物组合物
WO2017111637A1 (en) Pharmaceutical composition comprising dabigatran or a pharmaceutically acceptable salt thereof
HK40055441A (en) Oral pharmaceutical compositions of dabigatran etexilate
KR20100130882A (ko) 서방성 비스테로이드성 소염제 조성물 및 그 제조방법
HK1203832B (en) Oral pharmaceutical compositions of dabigatran etexilate
WO2025046547A1 (en) A stable solid oral dosage form of dabigatran
HK1192723B (en) Pharmaceutical composition containing diamine derivative
HK1168790A (en) Pharmaceutical composition having improved solubility

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20220110

Address after: Barcelona

Applicant after: TOVA pharmaceutical Europe Co.,Ltd.

Address before: Barcelona

Applicant before: Esteve Pharmaceutical Co.,Ltd.

TA01 Transfer of patent application right
RJ01 Rejection of invention patent application after publication

Application publication date: 20190816

RJ01 Rejection of invention patent application after publication