CN110121348A - 包含ed-71的固体分散体及油分散体的药物组合物 - Google Patents
包含ed-71的固体分散体及油分散体的药物组合物 Download PDFInfo
- Publication number
- CN110121348A CN110121348A CN201780081610.0A CN201780081610A CN110121348A CN 110121348 A CN110121348 A CN 110121348A CN 201780081610 A CN201780081610 A CN 201780081610A CN 110121348 A CN110121348 A CN 110121348A
- Authority
- CN
- China
- Prior art keywords
- soluble polymer
- water soluble
- cellulose
- oil
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dispersion Chemistry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016-256379 | 2016-12-28 | ||
JP2016256379 | 2016-12-28 | ||
PCT/JP2017/047156 WO2018124260A1 (fr) | 2016-12-28 | 2017-12-28 | Composition médicinale comprenant une dispersion solide de ed-71 et une dispersion d'huile |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110121348A true CN110121348A (zh) | 2019-08-13 |
Family
ID=62709373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780081610.0A Pending CN110121348A (zh) | 2016-12-28 | 2017-12-28 | 包含ed-71的固体分散体及油分散体的药物组合物 |
Country Status (5)
Country | Link |
---|---|
JP (2) | JP6905538B2 (fr) |
KR (2) | KR102366186B1 (fr) |
CN (1) | CN110121348A (fr) |
TW (1) | TWI784997B (fr) |
WO (1) | WO2018124260A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110946844A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 一种含有艾地骨化醇的复方控释制剂 |
CN110946837A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 用于治疗骨质疏松症的艾地骨化醇片及其制备方法 |
CN112368000A (zh) * | 2018-06-27 | 2021-02-12 | 中外制药株式会社 | 含有在油脂中包含ed-71及其环氧体的油分分散体的药物组合物 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112770750A (zh) * | 2018-07-30 | 2021-05-07 | 中外制药株式会社 | 乙内酰脲衍生物的固体分散体 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4729895A (en) * | 1983-02-22 | 1988-03-08 | Teijin Limited | Composition for solid pharmaceutical preparations of active vitamins D.sub.3 |
JPH02240024A (ja) * | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンd↓3類製剤用組成物 |
US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
EP1336602A1 (fr) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Prodrogues nitrées capable de libérer du monoxyde d'azote de manière controlée et sélective ainsi que leur utilisation pour la prévention et le traitement de maladies inflammatoires, ischémiques et proliferatives |
CN1615139A (zh) * | 2002-01-15 | 2005-05-11 | Dsmip资产有限公司 | 25-羟基维生素d3组合物 |
WO2005074943A1 (fr) * | 2004-02-06 | 2005-08-18 | Chugai Seiyaku Kabushiki Kaisha | Preparation de l’ed-71 |
WO2006075690A1 (fr) * | 2005-01-14 | 2006-07-20 | Ono Pharmaceutical Co., Ltd. | Composition medicale stable |
JP2007099760A (ja) * | 2005-09-06 | 2007-04-19 | Ono Pharmaceut Co Ltd | 軟骨再生用医薬組成物 |
CN101534834A (zh) * | 2006-11-06 | 2009-09-16 | 韩美药品株式会社 | 包含维生素d或其衍生物的固体分散体和双膦酸盐的用于预防或治疗骨质疏松症的复合制剂 |
CN101636152A (zh) * | 2007-02-15 | 2010-01-27 | 株式会社Amorepacific | 含有西洛他唑的控释制剂及其制备方法 |
CN102688249A (zh) * | 2012-05-14 | 2012-09-26 | 北京阜康仁生物制药科技有限公司 | 一种含有锶盐的药用组合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58206533A (ja) * | 1982-05-27 | 1983-12-01 | Teijin Ltd | 活性型ビタミンd↓3誘導体組成物及びそれを活性成分とする薬剤 |
JPS6217A (ja) * | 1985-02-14 | 1987-01-06 | Chugai Pharmaceut Co Ltd | 安定な活性型ビタミンd3類製剤 |
US9247765B2 (en) * | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
JP4934840B2 (ja) * | 2008-08-20 | 2012-05-23 | 石川県 | 脂溶性ビタミンないし脂溶性ビタミン様物質の油脂−糖質粉末素材及びその製造方法 |
WO2015119183A1 (fr) * | 2014-02-05 | 2015-08-13 | 協和発酵キリン株式会社 | Médicament liquide contenant de la vitamine d3 active ou un dérivé de celle-ci |
-
2017
- 2017-12-28 KR KR1020197019067A patent/KR102366186B1/ko active IP Right Grant
- 2017-12-28 CN CN201780081610.0A patent/CN110121348A/zh active Pending
- 2017-12-28 TW TW106146225A patent/TWI784997B/zh active
- 2017-12-28 WO PCT/JP2017/047156 patent/WO2018124260A1/fr active Application Filing
- 2017-12-28 KR KR1020227004397A patent/KR102583517B1/ko active IP Right Grant
- 2017-12-28 JP JP2018559626A patent/JP6905538B2/ja active Active
-
2021
- 2021-06-24 JP JP2021104906A patent/JP7196239B2/ja active Active
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4729895A (en) * | 1983-02-22 | 1988-03-08 | Teijin Limited | Composition for solid pharmaceutical preparations of active vitamins D.sub.3 |
US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
JPH02240024A (ja) * | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンd↓3類製剤用組成物 |
CN1615139A (zh) * | 2002-01-15 | 2005-05-11 | Dsmip资产有限公司 | 25-羟基维生素d3组合物 |
EP1336602A1 (fr) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Prodrogues nitrées capable de libérer du monoxyde d'azote de manière controlée et sélective ainsi que leur utilisation pour la prévention et le traitement de maladies inflammatoires, ischémiques et proliferatives |
WO2005074943A1 (fr) * | 2004-02-06 | 2005-08-18 | Chugai Seiyaku Kabushiki Kaisha | Preparation de l’ed-71 |
CN101721708A (zh) * | 2004-02-06 | 2010-06-09 | 中外制药株式会社 | Ed-71制剂 |
WO2006075690A1 (fr) * | 2005-01-14 | 2006-07-20 | Ono Pharmaceutical Co., Ltd. | Composition medicale stable |
JP2007099760A (ja) * | 2005-09-06 | 2007-04-19 | Ono Pharmaceut Co Ltd | 軟骨再生用医薬組成物 |
CN101534834A (zh) * | 2006-11-06 | 2009-09-16 | 韩美药品株式会社 | 包含维生素d或其衍生物的固体分散体和双膦酸盐的用于预防或治疗骨质疏松症的复合制剂 |
CN101636152A (zh) * | 2007-02-15 | 2010-01-27 | 株式会社Amorepacific | 含有西洛他唑的控释制剂及其制备方法 |
CN102688249A (zh) * | 2012-05-14 | 2012-09-26 | 北京阜康仁生物制药科技有限公司 | 一种含有锶盐的药用组合物 |
Non-Patent Citations (6)
Title |
---|
HAGINO H ET AL: "Eldecalcitol: newly developed active vitamin D-3 analog for the treatment of osteoporosis", 《EXPERT OPIN. PHARMACOTHER.》 * |
张光杰 等: "《药用辅料应用技术》", 31 December 1991, 中国医药科技出版社 * |
方亮: "《药剂学》", 31 March 2016, 中国医药科技出版社 * |
杨艳兰 等: "2β-(3羟丙氧)-骨化三醇对OS-732人成骨样细胞增殖与分化的影响", 《中华老年医学杂志》 * |
甄汉深 等: "《药物分析学》", 31 October 2011, 中国中医药出版社 * |
郝敬东 等: "肢体延长的大鼠模型", 《中华小儿外科杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112368000A (zh) * | 2018-06-27 | 2021-02-12 | 中外制药株式会社 | 含有在油脂中包含ed-71及其环氧体的油分分散体的药物组合物 |
CN110946844A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 一种含有艾地骨化醇的复方控释制剂 |
CN110946837A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 用于治疗骨质疏松症的艾地骨化醇片及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
TWI784997B (zh) | 2022-12-01 |
JP2021155437A (ja) | 2021-10-07 |
KR102583517B1 (ko) | 2023-09-26 |
KR102366186B1 (ko) | 2022-02-21 |
JP6905538B2 (ja) | 2021-07-21 |
JP7196239B2 (ja) | 2022-12-26 |
WO2018124260A1 (fr) | 2018-07-05 |
KR20220025177A (ko) | 2022-03-03 |
JPWO2018124260A1 (ja) | 2019-10-31 |
TW201834661A (zh) | 2018-10-01 |
KR20190101981A (ko) | 2019-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110121348A (zh) | 包含ed-71的固体分散体及油分散体的药物组合物 | |
CN102451179B (zh) | 一种含番茄红素,白藜芦醇或褪黑素的肠溶固体制剂及其制备方法 | |
CN105828806A (zh) | 制剂 | |
NO333301B1 (no) | Farmasoytisk sammensetning som inneholder fenofibrat og fremgangsmate til fremstilling derav | |
CN1741748A (zh) | 粉末状植物甾醇配方 | |
CN105007898A (zh) | 难溶性药物的过饱和的稳定纳米颗粒 | |
KR20090092288A (ko) | 뉴로키닌 길항제를 포함하는 제약 제형 | |
CA3110020A1 (fr) | Formes posologiques pediatriques de vitamine d, procedes de fabrication et d'utilisation de celles-ci | |
Xue et al. | A combined utilization of Plasdone-S630 and HPMCAS-HF in ziprasidone hydrochloride solid dispersion by hot-melt extrusion to enhance the oral bioavailability and no food effect | |
JP6053425B2 (ja) | ジベンゾ[b,e]オキセピン誘導体を含有する固形製剤 | |
JP2000191516A (ja) | 経口固形組成物 | |
CN104619175A (zh) | 延长释放左乙拉西坦和制备方法 | |
JP4060027B2 (ja) | ビタミンk含有組成物 | |
EP2050436A1 (fr) | Composition pharmaceutique qui comporte de la dutastéride | |
JP2015078183A (ja) | 固体分子分散物 | |
JP3833314B2 (ja) | 発泡性組成物およびその製造方法 | |
CN105435239B (zh) | 美索舒利薄膜衣片及其制备方法 | |
WO2023168316A1 (fr) | Formulations de cannabinoïdes sous forme de poudre sèche à enrobage entérique | |
Wang et al. | Preparation and evaluation of tamsulosin hydrochloride sustained-release pellets modified by two-layered membrane techniques | |
JP3895757B1 (ja) | 粉末状組成物 | |
JP7406581B2 (ja) | 油脂中にed-71およびそのエポキシ体を含む油分分散体を含む医薬組成物 | |
CN113893222B (zh) | 一种药物组合物及其制备方法和用途 | |
Aung et al. | Supersaturable Solid Self-microemulsifying Delivery Systems of Astaxanthin via Spray Drying: Effects of Polymers and Solid Carriers | |
JPH02300117A (ja) | 固形医薬製剤の製造方法 | |
JPH11209306A (ja) | 高薬物含有率徐放製剤の製法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40007075 Country of ref document: HK |