JP6905538B2 - Ed−71の固体分散体および油分分散体を含む医薬組成物 - Google Patents
Ed−71の固体分散体および油分分散体を含む医薬組成物 Download PDFInfo
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- JP6905538B2 JP6905538B2 JP2018559626A JP2018559626A JP6905538B2 JP 6905538 B2 JP6905538 B2 JP 6905538B2 JP 2018559626 A JP2018559626 A JP 2018559626A JP 2018559626 A JP2018559626 A JP 2018559626A JP 6905538 B2 JP6905538 B2 JP 6905538B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dispersion Chemistry (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021104906A JP7196239B2 (ja) | 2016-12-28 | 2021-06-24 | Ed-71の固体分散体および油分分散体を含む医薬組成物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016256379 | 2016-12-28 | ||
JP2016256379 | 2016-12-28 | ||
PCT/JP2017/047156 WO2018124260A1 (fr) | 2016-12-28 | 2017-12-28 | Composition médicinale comprenant une dispersion solide de ed-71 et une dispersion d'huile |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021104906A Division JP7196239B2 (ja) | 2016-12-28 | 2021-06-24 | Ed-71の固体分散体および油分分散体を含む医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2018124260A1 JPWO2018124260A1 (ja) | 2019-10-31 |
JP6905538B2 true JP6905538B2 (ja) | 2021-07-21 |
Family
ID=62709373
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018559626A Active JP6905538B2 (ja) | 2016-12-28 | 2017-12-28 | Ed−71の固体分散体および油分分散体を含む医薬組成物 |
JP2021104906A Active JP7196239B2 (ja) | 2016-12-28 | 2021-06-24 | Ed-71の固体分散体および油分分散体を含む医薬組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021104906A Active JP7196239B2 (ja) | 2016-12-28 | 2021-06-24 | Ed-71の固体分散体および油分分散体を含む医薬組成物 |
Country Status (5)
Country | Link |
---|---|
JP (2) | JP6905538B2 (fr) |
KR (2) | KR102366186B1 (fr) |
CN (1) | CN110121348A (fr) |
TW (1) | TWI784997B (fr) |
WO (1) | WO2018124260A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2020004541A1 (ja) * | 2018-06-27 | 2021-07-08 | 中外製薬株式会社 | 油脂中にed−71およびそのエポキシ体を含む油分分散体を含む医薬組成物 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112770750A (zh) * | 2018-07-30 | 2021-05-07 | 中外制药株式会社 | 乙内酰脲衍生物的固体分散体 |
CN110946837A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 用于治疗骨质疏松症的艾地骨化醇片及其制备方法 |
CN110946844A (zh) * | 2019-12-11 | 2020-04-03 | 正大制药(青岛)有限公司 | 一种含有艾地骨化醇的复方控释制剂 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58206533A (ja) * | 1982-05-27 | 1983-12-01 | Teijin Ltd | 活性型ビタミンd↓3誘導体組成物及びそれを活性成分とする薬剤 |
JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンd↓3類組成物 |
JPS6217A (ja) * | 1985-02-14 | 1987-01-06 | Chugai Pharmaceut Co Ltd | 安定な活性型ビタミンd3類製剤 |
JP2525478B2 (ja) * | 1989-03-01 | 1996-08-21 | 帝人株式会社 | 安定性の改良された活性型ビタミンd▲下3▼類固型製剤 |
JPH02240024A (ja) * | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンd↓3類製剤用組成物 |
US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
EP1336602A1 (fr) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Prodrogues nitrées capable de libérer du monoxyde d'azote de manière controlée et sélective ainsi que leur utilisation pour la prévention et le traitement de maladies inflammatoires, ischémiques et proliferatives |
US9247765B2 (en) * | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
US20070129340A1 (en) * | 2004-02-06 | 2007-06-07 | Chugai Seiyaku Kabushiki Kaisha | Ed-71 preparation |
WO2006075690A1 (fr) * | 2005-01-14 | 2006-07-20 | Ono Pharmaceutical Co., Ltd. | Composition medicale stable |
JP2007099760A (ja) * | 2005-09-06 | 2007-04-19 | Ono Pharmaceut Co Ltd | 軟骨再生用医薬組成物 |
KR100822133B1 (ko) * | 2006-11-06 | 2008-04-15 | 한미약품 주식회사 | 비타민 d 또는 이의 유도체의 고체분산체 및비스포스포네이트를 포함하는, 골다공증 예방 또는 치료용복합제제 |
KR20080076382A (ko) * | 2007-02-15 | 2008-08-20 | (주)아모레퍼시픽 | 실로스타졸의 제어방출 제제 및 그 제조방법 |
JP4934840B2 (ja) * | 2008-08-20 | 2012-05-23 | 石川県 | 脂溶性ビタミンないし脂溶性ビタミン様物質の油脂−糖質粉末素材及びその製造方法 |
CN102688249A (zh) | 2012-05-14 | 2012-09-26 | 北京阜康仁生物制药科技有限公司 | 一种含有锶盐的药用组合物 |
WO2015119183A1 (fr) * | 2014-02-05 | 2015-08-13 | 協和発酵キリン株式会社 | Médicament liquide contenant de la vitamine d3 active ou un dérivé de celle-ci |
-
2017
- 2017-12-28 KR KR1020197019067A patent/KR102366186B1/ko active IP Right Grant
- 2017-12-28 CN CN201780081610.0A patent/CN110121348A/zh active Pending
- 2017-12-28 TW TW106146225A patent/TWI784997B/zh active
- 2017-12-28 WO PCT/JP2017/047156 patent/WO2018124260A1/fr active Application Filing
- 2017-12-28 KR KR1020227004397A patent/KR102583517B1/ko active IP Right Grant
- 2017-12-28 JP JP2018559626A patent/JP6905538B2/ja active Active
-
2021
- 2021-06-24 JP JP2021104906A patent/JP7196239B2/ja active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2020004541A1 (ja) * | 2018-06-27 | 2021-07-08 | 中外製薬株式会社 | 油脂中にed−71およびそのエポキシ体を含む油分分散体を含む医薬組成物 |
JP2022065053A (ja) * | 2018-06-27 | 2022-04-26 | 中外製薬株式会社 | 油脂中にed-71およびそのエポキシ体を含む油分分散体を含む医薬組成物 |
JP7291138B2 (ja) | 2018-06-27 | 2023-06-14 | 中外製薬株式会社 | 油脂中にed-71およびそのエポキシ体を含む油分分散体を含む医薬組成物 |
JP7406581B2 (ja) | 2018-06-27 | 2023-12-27 | 中外製薬株式会社 | 油脂中にed-71およびそのエポキシ体を含む油分分散体を含む医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
TWI784997B (zh) | 2022-12-01 |
JP2021155437A (ja) | 2021-10-07 |
KR102583517B1 (ko) | 2023-09-26 |
CN110121348A (zh) | 2019-08-13 |
KR102366186B1 (ko) | 2022-02-21 |
JP7196239B2 (ja) | 2022-12-26 |
WO2018124260A1 (fr) | 2018-07-05 |
KR20220025177A (ko) | 2022-03-03 |
JPWO2018124260A1 (ja) | 2019-10-31 |
TW201834661A (zh) | 2018-10-01 |
KR20190101981A (ko) | 2019-09-02 |
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