CN110051823A - 高纯度和优异产量的正确折叠的依那西普 - Google Patents

高纯度和优异产量的正确折叠的依那西普 Download PDF

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Publication number
CN110051823A
CN110051823A CN201811633164.2A CN201811633164A CN110051823A CN 110051823 A CN110051823 A CN 110051823A CN 201811633164 A CN201811633164 A CN 201811633164A CN 110051823 A CN110051823 A CN 110051823A
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CN
China
Prior art keywords
etanercept
protein
arginine
capto
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811633164.2A
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English (en)
Chinese (zh)
Inventor
荒川力
道格拉斯·法勒
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Ke Rongsheng Biological Science Co Ltd
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Ke Rongsheng Biological Science Co Ltd
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Application filed by Ke Rongsheng Biological Science Co Ltd filed Critical Ke Rongsheng Biological Science Co Ltd
Publication of CN110051823A publication Critical patent/CN110051823A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN201811633164.2A 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普 Pending CN110051823A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261699552P 2012-09-11 2012-09-11
US61/699,552 2012-09-11
CN201380058650.5A CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380058650.5A Division CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

Publications (1)

Publication Number Publication Date
CN110051823A true CN110051823A (zh) 2019-07-26

Family

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CN201811633164.2A Pending CN110051823A (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普
CN201380058650.5A Expired - Fee Related CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

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Country Status (33)

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US (6) US20140072560A1 (https=)
EP (1) EP2895188B1 (https=)
JP (3) JP2015533797A (https=)
KR (2) KR102133699B1 (https=)
CN (2) CN110051823A (https=)
AR (1) AR092532A1 (https=)
AU (2) AU2013315750B9 (https=)
BR (1) BR112015005161A2 (https=)
CA (1) CA2882551A1 (https=)
CL (1) CL2015000572A1 (https=)
CO (1) CO7400876A2 (https=)
CY (1) CY1120062T1 (https=)
DK (1) DK2895188T3 (https=)
DO (1) DOP2015000055A (https=)
EA (1) EA031324B1 (https=)
EC (1) ECSP15014138A (https=)
ES (1) ES2657377T3 (https=)
HR (1) HRP20180182T1 (https=)
HU (1) HUE036524T2 (https=)
IL (2) IL237311B (https=)
IN (1) IN2015KN00452A (https=)
LT (1) LT2895188T (https=)
MX (2) MX360044B (https=)
NO (1) NO2972131T3 (https=)
PE (2) PE20150996A1 (https=)
PL (1) PL2895188T3 (https=)
PT (1) PT2895188T (https=)
RS (1) RS57013B1 (https=)
SG (1) SG11201501460RA (https=)
SI (1) SI2895188T1 (https=)
SM (1) SMT201800163T1 (https=)
TW (2) TWI716649B (https=)
WO (1) WO2014043103A1 (https=)

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US20190300602A1 (en) 2019-10-03
US20190330325A1 (en) 2019-10-31
HUE036524T2 (hu) 2018-07-30
KR20150056601A (ko) 2015-05-26
US20190300601A1 (en) 2019-10-03
CY1120062T1 (el) 2018-12-12
EP2895188A4 (en) 2016-05-25
AU2013315750B9 (en) 2018-11-15
JP6913066B2 (ja) 2021-08-04
US10954294B2 (en) 2021-03-23
EA201590542A1 (ru) 2015-07-30
HRP20180182T1 (hr) 2018-04-20
US11001627B2 (en) 2021-05-11
AU2018247244A1 (en) 2018-11-01
JP2019038817A (ja) 2019-03-14
AU2018247244B2 (en) 2020-05-28
PE20150996A1 (es) 2015-08-01
MX2015003090A (es) 2015-07-14
US20140072560A1 (en) 2014-03-13
IL267452B (en) 2021-05-31
JP2021100929A (ja) 2021-07-08
TW201425331A (zh) 2014-07-01
PL2895188T3 (pl) 2018-06-29
TW201803593A (zh) 2018-02-01
ECSP15014138A (es) 2016-01-29
WO2014043103A1 (en) 2014-03-20
CN104902914B (zh) 2019-01-01
US10947306B2 (en) 2021-03-16
SI2895188T1 (en) 2018-05-31
CO7400876A2 (es) 2015-09-30
SMT201800163T1 (it) 2018-05-02
AR092532A1 (es) 2015-04-22
CN104902914A (zh) 2015-09-09
CA2882551A1 (en) 2014-03-20
AU2013315750A1 (en) 2015-03-05
MX2018012749A (es) 2020-11-12
US20190300600A1 (en) 2019-10-03
EP2895188A1 (en) 2015-07-22
EA031324B1 (ru) 2018-12-28
IL237311B (en) 2019-07-31
KR102133699B1 (ko) 2020-07-14
KR102250937B1 (ko) 2021-05-12
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JP2015533797A (ja) 2015-11-26
US10954295B2 (en) 2021-03-23
RS57013B1 (sr) 2018-05-31
US20180037642A1 (en) 2018-02-08
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IL237311A0 (en) 2015-04-30
US10954293B2 (en) 2021-03-23
SG11201501460RA (en) 2015-04-29
PT2895188T (pt) 2018-02-08
KR20200085937A (ko) 2020-07-15
TWI609877B (zh) 2018-01-01
PE20200607A1 (es) 2020-03-10
EP2895188B1 (en) 2017-11-15
BR112015005161A2 (pt) 2017-07-04
LT2895188T (lt) 2018-04-10
AU2013315750B2 (en) 2018-07-12
ES2657377T3 (es) 2018-03-05
CL2015000572A1 (es) 2016-02-05
IL267452A (en) 2019-08-29
DOP2015000055A (es) 2015-04-30
TWI716649B (zh) 2021-01-21
MX360044B (es) 2018-10-19

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