CN109996870A - 从人多能干细胞产生中脑特异性类器官 - Google Patents

从人多能干细胞产生中脑特异性类器官 Download PDF

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CN109996870A
CN109996870A CN201780029142.2A CN201780029142A CN109996870A CN 109996870 A CN109996870 A CN 109996870A CN 201780029142 A CN201780029142 A CN 201780029142A CN 109996870 A CN109996870 A CN 109996870A
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cell
percentage
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culture medium
organoid
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曹重铉
黄学晖
诸炫秀
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Agency for Science Technology and Research Singapore
National University of Singapore
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National University of Singapore
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CN201780029142.2A 2016-03-14 2017-03-14 从人多能干细胞产生中脑特异性类器官 Pending CN109996870A (zh)

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SG10201601965P 2016-03-14
SG10201601965P 2016-03-14
PCT/SG2017/050126 WO2017160234A1 (fr) 2016-03-14 2017-03-14 Génération d'organoïdes spécifiques du mésencéphale à partir de cellules souches pluripotentes humaines

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US (1) US20190169576A1 (fr)
EP (1) EP3430132A4 (fr)
CN (1) CN109996870A (fr)
SG (2) SG10201913687VA (fr)
WO (1) WO2017160234A1 (fr)

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CN113046309A (zh) * 2021-03-26 2021-06-29 成都云测医学生物技术有限公司 悬浮培养脑类器官的培养基及其应用
CN113249319A (zh) * 2021-05-19 2021-08-13 北京大学 一种脑脊液类器官的培养基及其培养方法
CN113493768A (zh) * 2021-09-06 2021-10-12 中国科学院动物研究所 神经类器官及其制备方法
CN113684182A (zh) * 2020-05-19 2021-11-23 武汉睿健医药科技有限公司 TGF-β抑制剂在诱导神经干细胞及类器官形成中的应用
CN113789301A (zh) * 2021-08-27 2021-12-14 广州瑞臻再生医学科技有限公司 一种制备高纯度的诱导性多能干细胞来源的人脑多巴胺能神经元的方法
CN114736864A (zh) * 2020-12-23 2022-07-12 武汉睿健医药科技有限公司 一种神经干细胞诱导分化培养基及诱导分化方法
CN115044539A (zh) * 2022-08-16 2022-09-13 中义(北京)健康研究院 一种鲨鱼肝细胞及其培养方法
CN115404218A (zh) * 2022-01-13 2022-11-29 南华大学附属第一医院 一种包含胶质细胞的3d人脑类器官培养方法

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EP3712254A1 (fr) 2014-05-28 2020-09-23 Children's Hospital Medical Center Procédés et systèmes de conversion de cellules précurseurs dans des tissus gastriques à travers la différenciation dirigée
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
EP4177335A1 (fr) 2016-05-05 2023-05-10 Children's Hospital Medical Center Procédés de fabrication in vitro de tissu de fundus d'estomac et compositions associées à celui-ci
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SG10202105768WA (en) 2016-12-05 2021-06-29 Childrens Hospital Med Ct Colonic organoids and methods of making and using same
CN108456659B (zh) * 2018-03-14 2020-05-05 浙江霍德生物工程有限公司 3d大脑类器官的制备方法
CN110295145B (zh) * 2018-03-22 2020-10-16 苏州麦迪耐斯医药科技有限公司 一种体外培养脑肿瘤细胞的培养液及培养方法
JP2022500033A (ja) * 2018-09-11 2022-01-04 マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー． オルガノイドの自動化された生成および分析
US20220010271A1 (en) * 2018-11-15 2022-01-13 Jsr Corporation Method for producing brain organoids
JP2022519376A (ja) * 2019-02-11 2022-03-23 ミルテニイ ビオテック ベー．ファー． ウント コー．カーゲー 三次元マトリックスなしでのヒト多能性幹細胞由来人工組織構造体の生成
JP7366332B2 (ja) * 2019-06-05 2023-10-23 公立大学法人奈良県立医科大学 脳幹オルガノイドの作製方法
EP4001401A4 (fr) * 2019-07-05 2023-07-19 Keio University Procédé de fabrication d'organoïde cérébral
KR102228400B1 (ko) * 2019-09-24 2021-03-16 고려대학교 산학협력단 뇌 오가노이드 제조 방법
CN114729323A (zh) * 2019-11-22 2022-07-08 诺和诺德股份有限公司 旋转聚集的神经微球及其应用
EP4090734A1 (fr) * 2020-01-13 2022-11-23 Aspen Neuroscience, Inc. Procédé de différenciation de cellules nerveuses et compositions associées et méthodes d'utilisation
WO2021216622A1 (fr) * 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Édition génique de gba1 dans des cellules souches et procédé d'utilisation de cellules différenciées à partir de celles-ci
WO2021216623A1 (fr) * 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Édition génique de lrrk2 dans des cellules souches et procédé d'utilisation de cellules différenciées à partir de celles-ci
US20230323292A1 (en) * 2020-06-08 2023-10-12 Technische Universiteit Eindhoven Methods for producing a (three dimensional) neural tissue
WO2022005023A1 (fr) * 2020-06-29 2022-01-06 주식회사 오간팩토리 Organoïde de mésencéphale, son procédé de production rapide en grandes quantités, et procédé de criblage de neurotoxines et procédé de criblage de médicaments pour une maladie associée aux neurones dopaminergiques l'utilisant
KR102346243B1 (ko) * 2020-06-29 2022-01-04 주식회사 오간팩토리 중뇌 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 신경독성물질 스크리닝 방법 및 도파민성 신경세포 관련 질환 치료제 스크리닝 방법
EP3992280A1 (fr) * 2020-10-30 2022-05-04 Kugelmeiers Ltd. Procédé de génération de neurosphères
KR20230081737A (ko) * 2021-11-29 2023-06-08 주식회사 오간팩토리 간 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 약물의 효능 및 독성 스크리닝 방법
WO2023137200A2 (fr) * 2022-01-13 2023-07-20 The Board Of Trustees Of The Leland Stanford Junior University Génération d'organoïdes d'organisateur neuronal et d'assembloïdes de ligne médiane à partir de cellules souches pluripotentes humaines
WO2023201046A1 (fr) * 2022-04-14 2023-10-19 Lieber Institute, Inc. Compositions et méthode de traitement d'une dystonie-parkinsonisme liée à l'x
EP4286513A1 (fr) 2022-06-03 2023-12-06 IMBA-Institut für Molekulare Biotechnologie GmbH Fusion de culture de tissus triple
WO2024017538A1 (fr) * 2022-07-19 2024-01-25 Medizinische Hochschule Hannover Procédé de production d'organoïdes à partir de cellules de mammifère
EP4310177A1 (fr) * 2022-07-19 2024-01-24 Medizinische Hochschule Hannover Procédé de production d'organoïdes à partir de cellules de mammifères
WO2024113351A1 (fr) * 2022-12-02 2024-06-06 Nuwacell Biotechnologies Co., Ltd. Milieu de culture, matrice de revêtement et procédé de maturation de cellules progénitrices dopaminergiques du mésencéphale
CN117778313B (zh) * 2024-02-23 2024-05-24 成都云测医学生物技术有限公司 脑类器官获得间充质干细胞分化方法和应用

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