CN109953926A - Five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof - Google Patents
Five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses one kind to have five dimensions crease-resistant, skin care item of Antiageing effect and preparation method thereof, by adding niacinamide-containing in formula, overlay film saccharomycetes to make fermentation Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5, Argireline, the various ingredients such as dimethyl silane alcohol hyaluronic acid ester, it can reach and increase epidermis and skin corium degree of adhesion, promote the synthesis of collagen, calm nerves, reduce expression line, supplement silicon, improve skin elasticity, anti- saccharification, five dimensions improvement skins achieve the effect that anti crease and anti senile；Simultaneously because this is water solubility at subassembly, is not limited by product forms, aqua, lotion, cream, essence etc. can be made an addition to；Thoroughly compensate for the obvious shortcoming that commercial product has a single function.
Description
Technical field
The present invention relates to a kind of with five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof, more particularly to one kind
With five crease-resistant, Antiageing effect the prescriptions of dimension, which is mentioned by niacinamide, overlay film saccharomycetes to make fermentation Product filtrate, centella
Take object, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5, Argireline, diformazan
Base silanol hyaluronic acid ester composition, can be used for crease-resistant, anti-ageing cosmetics and drug
Background technique
With advancing age, the collagen of human body is gradually lost, and especially facial skin skin corium collagen is lost, and elasticity lacks
Mistake problem is particularly acute, and resists years aging to extend the skin service life, skin is badly in need of being saved.However currently usedization
Most of cosmetic has that effect is indefinite and certain adverse reaction occurs, and people are highly desirable to definite effect, make
With by way of multiplicity, safely, have no adverse reaction have crease-resistant, Antiageing effect product.The present invention passes through in removing moisturizing formula
Niacinamide, overlay film saccharomycetes to make fermentation Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice is added to extract
Object, Cer NP, palmityl tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester at subassembly, one
Increase epidermis and skin corium degree of adhesion, two promote the synthesis of collagen, and three calm nerves reduce expression line, and four supplement silicon change
Kind skin elasticity, five anti-saccharification achieve the effect that anti crease and anti senile from five dimensions improvement skins；Simultaneously because this is at subassembly
Water solubility can make an addition to aqua, lotion, cream, essence etc. so not limited by product forms.
Summary of the invention
The purpose of the present invention is to solve the above problems, and provide a kind of definite effect, purposes multiplicity, safety, invariably
Good reaction has five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof.
To achieve the goals above, the present invention adopts the following technical scheme:
It is a kind of to tie up crease-resistant, Antiageing effect skin care item with five, which is characterized in that including following components: niacinamide, overlay film
Saccharomycetes to make fermentation Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palm
Acyl tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester.
Further, the component is by weight percentage are as follows: niacinamide is 0.5%~2%, overlay film saccharomycetes to make fermentation product
Filtrate is 0.5%~2%, Gotu Kola P.E is 0.5%~2%, beta glucan is 0.5%~2%, pomegranate berry extract is
0.5%~2%, rice extract is 0.5%~2%, Cer NP is 0.5%~2%, palmityl tripeptides -5 be 0.1%~
1%, Argireline is 0.1%~1%, dimethyl silane alcohol hyaluronic acid ester is 0.1%~1%.
Further, the component is by weight percentage are as follows: niacinamide 2%, overlay film saccharomycetes to make fermentation Product filtrate are
2%, Gotu Kola P.E 2%, beta glucan 2%, pomegranate berry extract are 2%, rice extract is 2%, Cer NP
It is 1% for 2%, palmityl tripeptides -5, Argireline 1%, dimethyl silane alcohol hyaluronic acid ester are 1%.
Further, the component is by weight percentage are as follows: niacinamide 1.5%, overlay film saccharomycetes to make fermentation Product filtrate
For 1.5%, Gotu Kola P.E 1.5%, beta glucan 1.5%, pomegranate berry extract be 1.5%, rice extract is
1.5%, Cer NP 1.5%, palmityl tripeptides -5 be 0.5%, Argireline 0.5%, dimethyl silane alcohol
Hyaluronic acid ester is 0.5%.
Further, the component is by weight percentage are as follows: niacinamide 0.5%, overlay film saccharomycetes to make fermentation Product filtrate
For 0.5%, Gotu Kola P.E 0.5%, beta glucan 0.5%, pomegranate berry extract be 0.5%, rice extract is
0.5%, Cer NP 0.5%, palmityl tripeptides -5 be 0.1%, Argireline: 0.1%, dimethyl silane alcohol
Hyaluronic acid ester is 0.1%.
It further, further include following components: dipropylene glycol, ethylhexyl palmitate, carbonic acid dioctyl ester, cetanol ethyl
Capronate, dimethyl silicone polymer, arachidic alcohol, docosyl alcohol, arachidic alcohol glucoside, octyl dodecanol, stearyl alcohol, cetostearyl alcohol
The smooth olive oleate of olive oleate, sorb, C14-22 alcohol, C12-20 alkyl glucoside, polyacrylate -13, polyisobutene,
It is polysorbate -20, cetostearyl alcohol, polymethylsilsesquioxane, 1,3- propylene glycol, decoyl hydroximic acid, 1,2- hexylene glycol, right
Hydroxy acetophenone, Sensiva SC50, carbomer, tromethamine, ceteth -10, laureth -4, gathers pungent glycol
Sodium acrylate, EDETATE SODIUM, essence, water.
A kind of preparation method with five crease-resistant, Antiageing effect the skin care item of dimension, includes the following steps:
(1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
(2) by ethylhexyl palmitate, carbonic acid dioctyl ester, cetanol ethylhexoate, dimethyl silicone polymer, peanut
Alcohol, docosyl alcohol, arachidic alcohol glucoside, octyl dodecanol, stearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleic acid of sorb
Ester, C14-22 alcohol, C12-20 alkyl glucoside, polyacrylate -13, polyisobutene, polysorbate -20, cetostearyl alcohol,
Oily phase pot is added in polymethylsilsesquioxane, and warming while stirring is uniformly mixed it to 80 DEG C~85 DEG C, keeps the temperature 10~15 points
Clock；
(3) by water, dipropylene glycol, parahydroxyacet-ophenone, carbomer, water, ceteth -10, laureth -4, poly-
Water phase pot is added in sodium acrylate, EDETATE SODIUM, and warming while stirring makes it dissolve sufficiently heat preservation 10~15 to 80 DEG C~85 DEG C
Minute；
(4) water phase pot mixture is first pumped into 75~85 DEG C, then slowly takes out oily phase pot mixture by preheating emulsion pot
Enter, emulsifying 15~30 minutes, keeps the temperature 15~25 minutes；
(5) 35~45 DEG C are cooled to, niacinamide, overlay film saccharomycetes to make fermentation Product filtrate, centella (CENTELLA is added
ASIATICA) extract, beta glucan, pomegranate (PUNICA GRANATUM) berry extract, rice (ORYZA SATIVA) are extracted
It is object, Cer NP, palmityl tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester, 1,3- propylene glycol, pungent
Acyl hydroximic acid, 1,2- hexylene glycol, pungent glycol, Sensiva SC50, tromethamine, essence, and be sufficiently stirred；
(6) 30~38 DEG C are cooled to, is discharged, is stood；
(7) after the assay was approved, filling, packaging, coding, storage are stand-by.
Niacinamide is also known as vitamin B3, as a kind of medical components have very high safety and clinic skin
The basic vitamins replenishers of one of section's treatment, are ready for use on treatment photosensitive dermatitis, acne etc. relatively broadly.In recent years
Come research have shown that, it inhibit melanin pigmentation, in terms of also have good curative effect；Based on this feature, niacinamide
Further extension has been obtained in the application of cosmetic field, other than traditional whitening effect, also be used to reduce raw
At the melanin of, precipitating, its transfer to cells of superficial layer is obstructed, accelerate that cell metabolism, to accelerate melanin horn cell de-
It falls.Niacinamide is able to maintain that skin water content, promotes skin corium microcirculation.Niacinamide can also greatly reduce or to eliminate skin old
Change phenomenon, for example wrinkle, peeling, pore are coarse etc., reduce injury of the free radical to skin, play pre- anti-aging, repair skin
The effect obscure with face is reduced.
Overlay film saccharomycetes to make fermentation Product filtrate is that ingredient is sufficiently complex rather than single component, component include amino acid,
Vitamin, mineral element and carbohydrate lymphatic temperament have and inhibit free radical, promote collagen synthesis, eliminate fine wrinkles, provide
Skin nutrition improves the effect of skin quality.
Gotu Kola P.E can make skin limber up with compact epidermis and corium coupling part, help to solve skin
Relaxation (especially postpartum mother), keeps skin smooth flexible；Help promotes collagen in skin corium to be formed, and makes fiber egg
White regeneration, reconnect are got up, and mother's line is inherently eliminated, and achieve the effect that skin compact smooth.It can also help to be damaged
Organization healing and consolidation skin.It can promote the close connection between epidermis and corium and inhibit the increase of fat cell,
It prevents hydroderma, obesity occur.Plant Umbelliferae, subdhing swelling and detoxicating are dispelled running sore.Using on cosmetic industry, it can be achieved
A outstanding mildy wash, such as centella mildy wash are suitble to skin: any skin.In, stemness, Aging and sensibility flesh
Skin.The multiple efficacies such as the synthesis with antibacterial, anti-inflammatory, promotion fibroblast and collagen, the product is in after-sun restorative, wound
The personal care articles such as mouth healing, scar reparation, anti-aging.Triterpenoid of the Gotu Kola P.E containing a variety of 2 botany bar gum alcohol type of α,
Wherein there is asiaticosid, thankuniside, isothankuniside, madecassoside, Brahmoside, break hot rice glycosides and Brahmic acid
Deng, and madasiatic acid.In addition, still containing meso inositol, centellose (a kind of oligosaccharides), wax, carrot hydro carbons, Ye Lv
Element, and the flavonoid glycoside of Kaempferol, Quercetin and glucose, rhamnose.Go wrinkle Firm-stimulation cell turnover, strengthen blood vessel,
The effects of capillary and the increase degree of packing.The generation of print-promotion skin catabolic enzyme is gone, remaining toxin is decomposed rapidly, helps blood
Smooth outflow accelerates decline dark sore print.Anti-acne-is clearing heat and detoxicating, effectively eliminates skin redness, shouting pain, inflammatory reaction.Antioxygen
Damage of the oxygen radical to skin skin corium collagen, elastic collagen in change-elimination sunlight.Whitening-promotion table
Cornification simultaneously helps to create new connective tissue.The effect of the rouge that lose weight-disappears detumescence.
Beta glucan can promote collagen and elastin laminin in skin to increase, and so as to improve skin appearance and improve skin
The effect of wrinkle.Beta glucan can activate immunocompetent cell, to increase epidermal growth factor (EGF), improve skin appearance
And wrinkle reduction；Promote wound healing and scar desalination effect；Langerhans' cells can be promoted to be proliferated so as to enhance skin
It is immune；With anti-sunlight function and it can be reduced pain inflammation.Except tool film forming, moisture-keeping function, repair wound, anti-inflammatory and aquation
Outside；Also it can promote circulation and adjust immune function.Its moisture-retaining capacity is better than sodium hyaluronate.
Pomegranate berry extract extracts from pomegranate fruit, and the change such as tannin, flavones, organic acid, alkaloid is mainly contained in pomegranate fruit
It studies point.Pomegranate contains tannin, mannitol, sugar, natural gum, inulin, benzoaric acid, gallic acid and malic acid, pectin, grass
Sour calcium, isoquercitrin and granatenine etc..Benzoaric acid and gallic acid are pomegranate principle active components.Pomegranate also contains more
The amino acid such as glutamic acid, cystine, histidine, histidine etc. of kind needed by human body.Pomegranate berry extract contains the tannin of volume,
With anti-inflammatory and astriction, this can also be confirmed in inhibition of the Punica granatum L. extract to xanthine oxidase activity, yellow fast
Purine oxidizing ferment height is related with the aging of scytitis and skin, can inhibit scytitis and aging to its inhibition.Pomegranate
Berry extract contains the amino acid such as glutamic acid, cystine, histidine, histidine etc. there are many needed by human body, can promote collagen
The synthesis of albumen is suitable for anti-inflammatory, reparation, Rosemary Extract and anti-aging product.
Rice extract effectively inhibits the activity of elastoser, hyaluronidase and Collagenase, to provide skin
Elasticity and moisture；Effectively inhibit the generation of tyrosinase and melanin；Natural hair dye, antioxidant.
Cer NP can penetrate into skin quickly, help the update of skin natural containment, can promote nature aquation
Balance and cuticula in water combine, form a kind of reticular structure, lock moisture.There is good action to skin moisturizing maintenance,
It is skin-active ingredient important in cuticula, skin barrier can be enhanced, reconstituted cell forms effective barrier to prevent water loss
With the influence for reducing external environment.The especially needed more ceramides of stimulated skin, some researches show that wipe containing nerve
The product of amide component can be reduced red and swollen and percutaneous water loss, plays enhancing skin barrier and impaired skin is helped to alleviate drying
The effect of state.
Palmityl tripeptides -5 are a small molecule synthesis polypeptides, aim at pre- anti-wrinkle and are formed and improve wrinkle and design.It is more
Peptide is made of amino acid, amino acid be similarly including Skin Cell thus living cells main constituents.Polypeptide
It is raw material highly useful in cosmetic formulations, helps skin regeneration, reverses and early ageing is crossed by ultraviolet caused skin.Palmityl three
Peptide -5 is the small molecule tripeptides for possessing unique sequence, and the mechanism for simulating human body itself generates collagen by TGF-β, significant to increase
Add collagen and protecteds from degradation.Palmityl tripeptides -5 have improvement skin turgor, reduce various types wrinkle, make
Skin rejuvenates and smooth effect.
Argireline is one of the polypeptide products for fighting expression line, and it is multiple in SNARE that it can compete SNAP-25 albumen
The action site in object is closed, neurotransmitter regulator is reduced, to reduce contraction of muscle frequency, expression of releiving line.
Dimethyl silane alcohol hyaluronic acid ester has good permanent moistening effect, the reason is that containing in the structure of silanol
There is hydroxyl group abundant, it can form hydrogen bond between Free water, form dynamic equilibrium in epidermis, have immediately and persistently
Moisture-keeping efficacy.The grape amine glycan structures of hyalomitome acid group therein are also especially capable of fixing the water in skin histology simultaneously.It is applicable in
In the moisturizing of face and body skin, anti-aging, skin consolidation product etc..
The present invention complies fully with the indices in " cosmetics safety technical specification " (2015 editions) of country's promulgation, the shield
Skin product do not contain any noxious material.
Beneficial effects of the present invention: by adding niacinamide-containing, overlay film saccharomycetes to make fermentation Product filtrate, accumulated snow in formula
Careless extract, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5, Argireline,
The various ingredients such as dimethyl-silicon alkanol hyaluronic acid ester can reach and increase epidermis and skin corium degree of adhesion, promote collagen
Synthesis, calm nerves reduce expression line, supplement silicon, improve skin elasticity, anti-saccharification, five dimensions improve skins and reach anti-
It wrinkles anti-ageing effect；Simultaneously because this is water solubility at subassembly, is not limited by product forms, aqua, cream can be made an addition to
Liquid, cream, essence etc.；Thoroughly compensate for the obvious shortcoming that commercial product has a single function.
Specific embodiment
The present invention is illustrated below with reference to embodiment, but the present invention is not limited to these embodiments.
The present invention is achieved through the following technical solutions: it is a kind of with having five crease-resistant, Antiageing effect the skin care item of dimension, by
Following materials by weight percentage is prepared using conventional method:
1 composition of raw materials table of table
The specific preparation process of skin care item of the invention is as follows:
(1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
(2) by ethylhexyl palmitate, carbonic acid dioctyl ester, cetanol ethylhexoate, dimethyl silicone polymer, peanut
Alcohol, docosyl alcohol, arachidic alcohol glucoside, octyl dodecanol, stearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleic acid of sorb
Ester, C14-22 alcohol, C12-20 alkyl glucoside, polyacrylate -13, polyisobutene, polysorbate -20, cetostearyl alcohol,
Oily phase pot is added in polymethylsilsesquioxane, and warming while stirring is uniformly mixed it to 80 DEG C~85 DEG C, keeps the temperature 10~15 points
Clock；
(3) by water, dipropylene glycol, parahydroxyacet-ophenone, carbomer, water, ceteth -10, laureth -4, poly-
Water phase pot is added in sodium acrylate, EDETATE SODIUM, and warming while stirring makes it dissolve sufficiently heat preservation 10~15 to 80 DEG C~85 DEG C
Minute；
(4) water phase pot mixture is first pumped into 75~85 DEG C, then slowly takes out oily phase pot mixture by preheating emulsion pot
Enter, emulsifying 15~30 minutes, keeps the temperature 15~25 minutes；
(5) 35~45 DEG C are cooled to, niacinamide, overlay film saccharomycetes to make fermentation Product filtrate, centella (CENTELLA is added
ASIATICA) extract, beta glucan, pomegranate (PUNICA GRANATUM) berry extract, rice (ORYZA SATIVA) are extracted
It is object, Cer NP, palmityl tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester, 1,3- propylene glycol, pungent
Acyl hydroximic acid, 1,2- hexylene glycol, pungent glycol, Sensiva SC50, tromethamine, essence, and be sufficiently stirred；
(6) 30~38 DEG C are cooled to, is discharged, is stood；
(7) after the assay was approved, filling, packaging, coding, storage are stand-by.
Embodiment 1
Main component in embodiment 1 is constituted by following weight percent: niacinamide 2%, overlay film saccharomycetes to make fermentation produce
Object filtrate is 2%, Gotu Kola P.E 2%, beta glucan 2%, pomegranate berry extract are 2%, rice extract is 2%,
Cer NP is 2%, palmityl tripeptides -5 are 1%, Argireline 1%, dimethyl-silicon alkanol hyaluronic acid ester are
1%, dipropylene glycol 6%, ethylhexyl palmitate 4%, carbonic acid dioctyl ester 4%, cetanol ethylhexoate 4%, poly dimethyl
Siloxanes 3%, octyl dodecanol 2%, stearyl alcohol 1%, cetostearyl alcohol 0.5%, polymethylsilsesquioxane 0.5%, to hydroxyl
Benzoylformaldoxime 0.3%, carbomer 0.15%, tromethamine 0.15%, Sodium Polyacrylate 0.01%, EDETATE SODIUM 0.02%, water.
Other ingredients can be found in table 2.
Embodiment 2
Component in embodiment 2 is constituted by following weight percent: niacinamide 1.5%, overlay film saccharomycetes to make fermentation product
Filtrate is 1.5%, Gotu Kola P.E 1.5%, beta glucan 1.5%, pomegranate berry extract are 1.5%, rice extract
It is 0.5% for 1.5%, Cer NP 1.5%, palmityl tripeptides -5, Argireline 0.5%, dimethyl-silicon alkanol
Hyaluronic acid ester is 0.5%, dipropylene glycol 6%, ethylhexyl palmitate 4%, carbonic acid dioctyl ester 4%, cetanol thylhexoic acid
Ester 4%, dimethyl silicone polymer 3%, octyl dodecanol 2%, stearyl alcohol 1%, cetostearyl alcohol 0.5%, poly- methyl silicon sesquialter
Oxygen alkane 0.5%, parahydroxyacet-ophenone 0.3%, carbomer 0.15%, tromethamine 0.15%, Sodium Polyacrylate 0.01%, EDTA
Disodium 0.02%, water.Other ingredients can be found in table 2.
Embodiment 3
Component in embodiment 3 is constituted by following weight percent: niacinamide 0.5%, overlay film saccharomycetes to make fermentation product
Filtrate is 0.5%, Gotu Kola P.E 0.5%, beta glucan 0.5%, pomegranate berry extract are 0.5%, rice extract
It is 0.1% for 0.5%, Cer NP 0.5%, palmityl tripeptides -5, Argireline: 0.1%, dimethyl-silicon alkanol
Hyaluronic acid ester is 0.1%, dipropylene glycol 6%, ethylhexyl palmitate 4%, carbonic acid dioctyl ester 4%, cetanol thylhexoic acid
Ester 4%, dimethyl silicone polymer 3%, octyl dodecanol 2%, stearyl alcohol 1%, cetostearyl alcohol 0.5%, poly- methyl silicon sesquialter
Oxygen alkane 0.5%, parahydroxyacet-ophenone 0.3%, carbomer 0.15%, tromethamine 0.15%, Sodium Polyacrylate 0.01%, EDTA
Disodium 0.02%, water.Other ingredients can be found in table 2.
Table 2: each component content table of Examples 1 to 3
Six, technical effect
Divide the effect of the skin care item and certain commercially available brand skin care item (reference examples) of implementing 1~3 to comparison of testing,
In, the skin care item of implementation 1~3 and the constituent content of certain commercially available brand skin care item are referring to table 1.
1, skin smoothness change rate is tested
Look for female volunteers of 10 ages between 18~50 years old, respectively face using above have five dimension it is crease-resistant,
The skin care item of Antiageing effect and certain commercially available skin care item, study subject use once daily, are used continuously 30 days, do not make during test
With other any products.Under the conditions of 25 ± 1 DEG C of environment temperature, humidity 50 ± 5%, surveyed using VISIA face-image analyzer
Examination, comprehensive to obtain smoothness data, data value is higher, and expression skin smoothness is poorer.Test result is as follows table:
| Sample | Before use | After use |
| Embodiment 1 | 3.2455 | 1.5783 |
| Embodiment 2 | 3.1256 | 1.7328 |
| Embodiment 3 | 3.0973 | 1.8642 |
| Reference examples | 2.9457 | 2.9456 |
| Commercially available skin care item | 3.0847 | 2.9972 |
From the above experimental result as can be seen, skin smoothness of the present invention, is relatively not added with niacinamide, overlay film saccharomycetes to make fermentation
Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5,
The skin of Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester composition and commercially available common skin care item is flat
Slippery is good.
2, promote collagen synthesis test
Crease-resistant, Antiageing effect skin care item and commercially available certain skin care item Solution culture method mankind fiber original are tieed up carefully with five
Then born of the same parents measure collagen synthesis amount, comprehensive to obtain collagen synthesis amount data, the higher expression of data value promotes collagen egg
White synthesis capability is better.Test result is as follows table:
From the above experimental result as can be seen, the present invention promotes collagen synthesis ability, it is relatively not added with niacinamide, overlay film
Saccharomycetes to make fermentation Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palm
The reference examples and commercially available common skin care of acyl tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester composition
The promotion collagen synthesis ability of product is good.
3, anti-aging is tested
Crease-resistant, Antiageing effect skin care item and certain commercially available skin care item Solution culture method Caenorhabditis elegans are tieed up with five,
Then investigating has five to tie up crease-resistant, Antiageing effect skin care item and certain commercially available skin care item to the shadow in model organism caenorhabditis elegan service life
It rings.Test result is as follows table:
| Sample | Average life span (day) | Maximum life (day) |
| Embodiment 1 | 14.86±0.44d | 25.64±1.06d |
| Embodiment 2 | 12.97±0.75d | 22.86±0.85d |
| Embodiment 3 | 11.32±0.53d | 21.32±0.52d |
| Reference examples | 9.75±0.28d | 19.98±0.18d |
| Commercially available skin care item | 10.87±0.35d | 20.43±0.47d |
From the above experimental result as can be seen, anti-aging ability of the present invention, is relatively not added with niacinamide, overlay film saccharomycetes to make fermentation
Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5,
The anti-aging of Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester composition and commercially available common skin care item
Ability is good.
4, the test of expression line is reduced
Look for female volunteers of 10 ages between 40~60 years old, respectively forehead using above have five dimension it is crease-resistant,
The skin care item of Antiageing effect and certain commercially available skin care item, study subject use twice daily, are used continuously 28 days, do not make during test
With other any products.Under the conditions of 25 ± 1 DEG C of environment temperature, humidity 50 ± 5%, surveyed using VISIA face-image analyzer
Examination, the comprehensive wrinkle decrease rate data obtained compared with first day, it is better that the higher expression of wrinkle decrease rate reduces expression line ability.
Test result is as follows table:
| Sample | Wrinkle decrease rate (%) |
| Embodiment 1 | 51 |
| Embodiment 2 | 35 |
| Embodiment 3 | 19 |
| Reference examples | 0 |
| Commercially available skin care item | 8 |
From the above experimental result as can be seen, the present invention reduces expression line ability, it is relatively not added with niacinamide, overlay film saccharomycete
Tunning filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl three
Peptide -5, Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester composition and commercially available common skin care item
It is good to reduce expression line ability.
5, skin elasticity is tested
Look for female volunteers of 10 ages between 28~50 years old, respectively face using above have five dimension it is crease-resistant,
The skin care item of Antiageing effect and certain commercially available skin care item are used continuously 4 weeks, are tested using German MAP580 skinanalysis apparatus, comprehensive
Positioning elastic part amount of tension Ue is obtained, data value is higher, and expression skin elasticity is better.Test result is as follows table:
| Sample | Before use | After 2 weeks | After 4 weeks |
| Embodiment 1 | 0.257 | 0.325 | 0.497 |
| Embodiment 2 | 0.239 | 0.260 | 0.402 |
| Embodiment 3 | 0.241 | 0.254 | 0.328 |
| Reference examples | 0.231 | 0.234 | 0.233 |
| Commercially available skin care item | 0.252 | 0.254 | 0.261 |
From the above experimental result as can be seen, skin of the present invention, which restores elastic effect, is relatively not added with niacinamide, overlay film yeast
Bacterium tunning filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl three
Peptide -5, Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester composition and commercially available skin care item skin
It is significant to restore elastic effect.
6, epidermis and the test of skin corium degree of adhesion
Female volunteers of 10 ages between 28~50 years old are looked for, are used respectively in inboard arm anti-with five dimensions above
The skin care item and certain commercially available skin care item of wrinkle, Antiageing effect after continuous use 7 days, with 5%SDS lotion before test, impregnate skin 2
Hour, the percutaneous moisture loss rate of TEWL compared with before test is then tested using Tewameter tester, it is comprehensive to obtain TEWL
Percutaneous moisture loss rate, the lower expression epidermis of data value and skin corium degree of adhesion are good.Test result is as follows table:
| Sample | The percutaneous moisture loss rate % of TEWL |
| Embodiment 1 | 300 |
| Embodiment 2 | 500 |
| Embodiment 3 | 800 |
| Reference examples | 1200 |
| Commercially available skin care item | 1000 |
From the above experimental result as can be seen, epidermis of the present invention and skin corium degree of adhesion are relatively not added with niacinamide, overlay film ferment
Female bacterium tunning filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl
Tripeptides -5, Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester composition and commercially available skin care item table
Skin and skin corium degree of adhesion are significant.
7, anti-saccharification test
Female volunteers of 15 ages between 18-50 years old are looked for, are used respectively in face crease-resistant, anti-with five dimensions above
Decline the skin care item and certain commercially available skin care item of effect, and study subject uses twice daily, is used continuously 30 days, does not use during test
Other any products.Tested using German MAP580 skinanalysis apparatus, the saccharification inhibiting rate tested the result is as follows:
From the above experimental result as can be seen, the anti-saccharification capability of the present invention, is relatively not added with niacinamide, overlay film saccharomycetes to make fermentation
Product filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5,
The anti-saccharification result of Argireline, the reference examples of dimethyl silane alcohol hyaluronic acid ester and commercially available skin care item is significant.
The foregoing is merely better embodiments of the invention, and the invention is not limited to above embodiment, are implementing
The structural modification small there may be part in the process, if various changes or modifications of the invention are not departed from essence of the invention
Mind and range, and belong within the scope of claim and equivalent technologies of the invention, then the present invention is also intended to encompass these changes
And modification.
Claims (7)
1. a kind of with five crease-resistant, Antiageing effect the skin care item of dimension, which is characterized in that including following components: niacinamide, overlay film ferment
Female bacterium tunning filtrate, Gotu Kola P.E, beta glucan, pomegranate berry extract, rice extract, Cer NP, palmityl
Tripeptides -5, Argireline, dimethyl silane alcohol hyaluronic acid ester.
Have that five dimensions are crease-resistant, skin care item of Antiageing effect 2. according to claim 1, which is characterized in that the component is pressed
Weight percent are as follows: niacinamide is 0.5%~2%, overlay film saccharomycetes to make fermentation Product filtrate is 0.5%~2%, centella is extracted
Object is 0.5%~2%, beta glucan is 0.5%~2%, pomegranate berry extract is 0.5%~2%, rice extract is 0.5%
~2%, Cer NP is 0.5%~2%, palmityl tripeptides -5 are 0.1%~1%, Argireline be 0.1%~
1%, dimethyl silane alcohol hyaluronic acid ester 0.1%~1%.
Have that five dimensions are crease-resistant, skin care item of Antiageing effect 3. according to claim 2, which is characterized in that the component is pressed
Weight percent are as follows: niacinamide 2%, overlay film saccharomycetes to make fermentation Product filtrate be 2%, Gotu Kola P.E 2%, β-Portugal are poly-
Sugar is 2%, pomegranate berry extract is 2%, rice extract is 2%, Cer NP 2%, palmityl tripeptides -5 are 1%, acetyl
Base hexapeptide -8 is that 1%, dimethyl silane alcohol hyaluronic acid ester is 1%.
Have that five dimensions are crease-resistant, skin care item of Antiageing effect 4. according to claim 2, which is characterized in that the component is pressed
Weight percent are as follows: niacinamide 1.5%, overlay film saccharomycetes to make fermentation Product filtrate be 1.5%, Gotu Kola P.E 1.5%,
Beta glucan is 1.5%, pomegranate berry extract is 1.5%, rice extract is 1.5%, Cer NP 1.5%, palmityl three
Peptide -5 is 0.5%, Argireline 0.5%, dimethyl silane alcohol hyaluronic acid ester is 0.5%.
Have that five dimensions are crease-resistant, skin care item of Antiageing effect 5. according to claim 2, which is characterized in that the component is pressed
Weight percent are as follows: niacinamide 0.5%, overlay film saccharomycetes to make fermentation Product filtrate be 0.5%, Gotu Kola P.E 0.5%,
Beta glucan is 0.5%, pomegranate berry extract is 0.5%, rice extract is 0.5%, Cer NP 0.5%, palmityl three
Peptide -5 is 0.1%, Argireline: 0.1%, dimethyl silane alcohol hyaluronic acid ester is 0.1%.
Have that five dimensions are crease-resistant, skin care item of Antiageing effect 6. according to any one of claims 1-5, which is characterized in that
It further include following components: dipropylene glycol, ethylhexyl palmitate, carbonic acid dioctyl ester, cetanol ethylhexoate, poly dimethyl silicon
Oxygen alkane, arachidic alcohol, docosyl alcohol, arachidic alcohol glucoside, octyl dodecanol, stearyl alcohol, cetostearyl alcohol olive oleate, sorb are smooth
Olive oleate, C14-22 alcohol, C12-20 alkyl glucoside, polyacrylate -13, polyisobutene, polysorbate -20, whale
Wax stearyl alcohol, polymethylsilsesquioxane, 1,3- propylene glycol, decoyl hydroximic acid, 1,2- hexylene glycol, parahydroxyacet-ophenone, Xin Gan
Alcohol, Sensiva SC50, carbomer, tromethamine, ceteth -10, laureth -4, Sodium Polyacrylate, EDTA bis-
Sodium, essence, water.
7. it is a kind of for the preparation method with crease-resistant, Antiageing effect the skin care item of five dimensions as claimed in claims 1-5, it is special
Sign is, includes the following steps:
(1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
(2) by ethylhexyl palmitate, carbonic acid dioctyl ester, cetanol ethylhexoate, dimethyl silicone polymer, arachidic alcohol, mountain
Yu alcohol, arachidic alcohol glucoside, octyl dodecanol, stearyl alcohol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb,
C14-22 alcohol, polyacrylate -13, polyisobutene, polysorbate -20, cetostearyl alcohol, gathers C12-20 alkyl glucoside
Oily phase pot is added in methyl silsesquioxane, and warming while stirring is uniformly mixed it to 80 DEG C~85 DEG C, keeps the temperature 10~15 points
Clock；
(3) by water, dipropylene glycol, parahydroxyacet-ophenone, carbomer, water, ceteth -10, laureth -4, polypropylene
Water phase pot is added in sour sodium, EDETATE SODIUM, and warming while stirring makes it dissolve sufficiently to 80 DEG C~85 DEG C, keeps the temperature 10~15 minutes；
(4) water phase pot mixture is first pumped into 75~85 DEG C, is then slowly pumped into oily phase pot mixture by preheating emulsion pot,
Emulsifying 15~30 minutes, keep the temperature 15~25 minutes；
(5) 35~45 DEG C are cooled to, addition niacinamide, overlay film saccharomycetes to make fermentation Product filtrate, Gotu Kola P.E, β-Portugal are poly-
Sugar, pomegranate berry extract, rice extract, Cer NP, palmityl tripeptides -5, Argireline, dimethyl silane alcohol are saturating
Bright matter acid esters, 1,3-PD, decoyl hydroximic acid, 1,2- hexylene glycol, pungent glycol, Sensiva SC50, tromethamine, essence,
And it is sufficiently stirred；
(6) 30~38 DEG C are cooled to, is discharged, is stood；
(7) after the assay was approved, filling, packaging, coding, storage are stand-by.
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| CN110327244A (en) * | 2019-07-29 | 2019-10-15 | 陕西博鸿生物科技集团有限公司 | Reagent for skin care combines |
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| CN114617792A (en) * | 2022-03-28 | 2022-06-14 | 水羊化妆品制造有限公司 | Anti-aging composition, preparation method and application thereof, and anti-aging skin care product |
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| CN111973464A (en) * | 2020-09-04 | 2020-11-24 | 广州市轩颜化妆品有限公司 | Double-layer wrinkle-removing and wrinkle-comforting shaking cream for face and preparation method thereof |
| CN112451412A (en) * | 2020-12-15 | 2021-03-09 | 上海涂固安高科技有限公司 | Skin care composition containing nano SOD (superoxide dismutase), capable of resisting wrinkles, resisting aging and inhibiting bacteria and application |
| CN113332168A (en) * | 2021-06-02 | 2021-09-03 | 林琚 | Polypeptide and ceramide compounded anti-aging repair cream and preparation method thereof |
| CN114617792A (en) * | 2022-03-28 | 2022-06-14 | 水羊化妆品制造有限公司 | Anti-aging composition, preparation method and application thereof, and anti-aging skin care product |
| CN114617792B (en) * | 2022-03-28 | 2022-11-18 | 水羊化妆品制造有限公司 | Anti-aging composition, preparation method and application thereof, and anti-aging skin care product |
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