CN108283597A - A kind of polypeptide ageing-resistant skin care composition and its application - Google Patents

Abstract

The invention discloses a kind of polypeptide ageing-resistant skin care composition and its application, the component containing following parts by weight：0.1 10 parts of hydrolyzed soy fine powder, 0.1 10 parts of elastin hydrolysis, 0.1 10 parts of soluble protein polysaccharide, 8 0.1 10 parts of acetyl group hexapeptide.The present invention is by the way that hydrolyzed soy fine powder, elastin hydrolysis, soluble protein polysaccharide, acetyl group hexapeptide 8 to be used in compounding; it can be absorbed by skin; activating skin itself synthesizes hyaluronic acid and collagen; necessary nutrition is provided for skin; smooth microgroove; so that skin is restored flexible young state, there is long-acting anti-ageing effect.

Description

A kind of polypeptide ageing-resistant skin care composition and its application

Technical field

The present invention relates to cosmetic fields, and in particular to a kind of polypeptide ageing-resistant skin care composition and its application.

Background technology

Cosmetics are very popular as a kind of substance improving people's beauty degree.With people's living standard Raising, emphasis of the people to skin nursing be higher and higher to product requirement.

Skin aging is the skin aging phenomenon as caused by natural cause or non-natural factor.Skin histology day after people's birth It reaches increasingly, function is gradually active, will start to degenerate when reaching certain age, fortune kind is degenerated often unconsciously slow in people Slow-motion row.The growth stage of skin histology generally ends at 25 years old or so, this phase is generally referred to as " bent angle of skin ", hereafter grows certainly It is carried out at the same time with aging, Elastic fibers are gradually thicker, and 40-50 Sui reaches the just old phase, and the aging of skin is slowly apparent, but old Change degree varies with each individual.With the aging of skin, the thickness of skin is gradually thinning with atrophy, and subcutaneous fat is reduced, and due to Elastic fibers changes with collagenous fibres and gradually loses skin elasticity and tension, thus further results in cutis laxa and is produced with wrinkle It is raw.

Currently, skin care item in the market are very abundant, but for the skins such as dim mute, the dry, aging of the colour of skin, wrinkle element Random synthtic price index is still difficult to be improved simultaneously.

Invention content

The technical problem to be solved in the present invention is to provide a kind of polypeptide ageing-resistant skin care compositions.It can be inhaled by skin It receives, activating skin itself synthesizes hyaluronic acid and collagen, provides necessary nutrition for skin, smooths microgroove, keeps skin extensive Multiple flexible young state, has long-acting anti-ageing effect.

The specific technical solution to solve the above problems is as follows：

A kind of polypeptide ageing-resistant skin care composition, the component containing following parts by weight：0.1-10 parts of hydrolyzed soy fine powder, water Solve 0.1-10 parts of elastin laminin, 0.1-10 parts of soluble protein polysaccharide, 0.1-10 parts of Argireline.

Preferably, the skin care compositions also contains the component of following parts by weight：Red autumnal leaves Malpighia coccigera (MALPIGHIA PUNICIFOLIA) berry extract 0.1-10 parts, -50.1-10 parts of palmityl tripeptides.

The present invention also provides application of the skin care compositions in preparing cosmetics, the use of the skin care compositions Amount is the 0.1-10wt% of final products weight.

A kind of anti-aging face cream includes the component of following mass percentage：Above-mentioned skin care compositions 0.1-10%, glycerine Polymethacrylates 0.1-0.5%, caprylic/capric triglyceride 0.1-2%, propyloxy phenyl base dimethyl silicone polymer 0.1- 2%, Natrulon H-10 tristearate 0.1-1%, polyalcohol 5-15%, citric acid 0.01-0.1%, carbohydrate isomer 0.1-1%, sodium citrate 0.01-0.1%, hydroxyethyl cellulose 0.1-0.5%, Cremophor RH40 0.01-0.05%, Aminomethyl propylene glycol 0.1-0.5%, yeast beta-dextran 0.1-3%, EDETATE SODIUM 0.01-0.05%, rose (ROSARUGOSA) caul-fat 0.0001-0.001%, tapioca 0.1-0.5%, Sodium Hyaluronate 0.01-0.05%, preservative 0.2-0.6%, water surplus.

Soluble protein polysaccharide and yeast beta-dextran have the synthesis of collagen the effect of promotion, to promote skin Degree of compacting, improve skin elasticity, improve wrinkle；And have the function of moisturizing, the water lock moisturizing degree of skin can be increased.

Carbohydrate isomer (Pentavitin) derives from vegetalitas D-Glucose, contains glucose, fructose, sweet dew The ingredients such as sugar, galactolipin, psicose.Carbohydrate isomer, which is added, can improve the table of loricrin (Loricrin) gene Up to level, the function of hornification coating is influenced；Acid sphingomyelinase gene expression dose can also be improved, ceramide is stimulated Synthesis；Can improve the gene expression dose of a polyprotein and hyaluronic acid synthase 3, promote natural moisturizing factor NMF with thoroughly The combination of bright matter acid, so as to improve skin moisturizing ability.In addition, due to carbonyl and skin in the sugared structure of carbohydrate isomer Amino in skin keratin is combined, and is kept carbohydrate isomer closely coupled with keratin, is not easy to be washed off, only in skin It can be just removed when cuticula falls off naturally, so that carbohydrate isomer can enduringly play depth water lock and water conservation Function slow down skin irritatin and discomfort caused by cutin falls off or external environment to persistently improving skin roughness.

When the addition of carbohydrate isomer is between 0.1-1%, while face cream replenishing water and preserving moisture can be made, moreover it is possible to It is enough effectively improved skin pattern, skin is made to keep good moist degree.

Preferably, the polyalcohol is propylene glycol, butanediol, 1,2- pentanediols, 1,2- hexylene glycols, pungent glycol and ethyl hexyl One or more kinds of mixing in base glycerol.

Preferably, the preservative be DMDM hydantoin, parahydroxyacet-ophenone, one kind in Phenoxyethanol or it is a kind of with On mixing.

Preferably, the preparation method of the anti-aging face cream, includes the following steps：1) by shield as claimed in claim 1 or 2 It is skin composition, glycerine polymethacrylates, caprylic/capric triglyceride, propyloxy phenyl base dimethyl silicone polymer, poly- sweet Oily -10 tristearates are heated to 70-90 DEG C, and stirring and dissolving is spare as oil phase；2) by polyalcohol, citric acid, same point of carbohydrate Isomers, sodium citrate, hydroxyethyl cellulose, Cremophor RH40, aminomethyl propylene glycol, yeast beta-dextran, EDTA Disodium, rose (ROSARUGOSA) caul-fat, tapioca, Sodium Hyaluronate, preservative, water are heated to 70-90 DEG C, and stirring is molten Solution, it is spare as water phase；3) pressurize 0.1-10Mpa, water phase is injected in oil mixture, homogeneous, and homogeneous rate is 1000- Insulated and stirred 15-45 minutes after 5000rpm, 3-5 minutes；It releases stress, stirs, be cooled to room temperature.

The present invention has the advantages that：

The present invention is by compounding hydrolyzed soy fine powder, elastin hydrolysis, soluble protein polysaccharide, Argireline It uses, can be absorbed by skin, activating skin itself synthesizes hyaluronic acid and collagen, and necessary battalion is provided for skin It supports, smooths microgroove, so that skin is restored flexible young state, there is long-acting anti-ageing effect.

In addition red autumnal leaves Malpighia coccigera (MALPIGHIAPUNICIFOLIA) berry extract for adding, palmityl tripeptides -5, into one Step eliminates free radical, can active cell energy, promote skin cell metabolism, bright color further promotes anti-aging Effect.And skin can be adhered to very well, adjusts skin water loss, repairs dry cuticula, improves skin sparing barrier Quality restores the natural cover for defense of skin, and skin is made to become soft, smooth, high resilience.

Specific implementation mode

To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to Routine techniques carries out.

Hydrolyzed soy fine powder is full of nutrition, moisture-absorbing moisture-keeping, Disodium EDTA, good surface activity.

For elastin hydrolysis as collagen, the elastin laminin in skin is also to synthesize offer by fibroblast , in human dermis organize, the ratio of elastin laminin and collagen is 4:77, therefore can be used this ratio for the skin care of callus Skin microcirculation can be stimulated by being shared with soluble collagen, accelerated the speed of fibroblast synthesis collagen, reduced wrinkle Line；Elastin laminin, which is added, can supplement the content of the elastin laminin in aged skin, increase the flexibility of skin, greasy skin Cuticula；Elastin laminin has better compatibility to skin than collagen.

Soluble protein polysaccharide can increase the content of hyaluronic acid in fibroblast in skin, promote skin collagen egg White synthesis improves the elasticity of skin, crease-resistant to achieve the effect that.

Argireline is a kind of biologically active polypeptide, which can not only reduce existing facial wrinkles, but also can be effective Prevent new wrinkle from generating.By inhibiting the release of neurotransmitter acetylcholine (acetylcholine), to reduce muscle It shrinks, to reach the generation for reducing dynamic line, expression line.

Red autumnal leaves Malpighia coccigera (MALPIGHIAPUNICIFOLIA) berry extract has good promotion to the activity of epidermal cell, There is skin-active.

Palmityl tripeptides -5 are skin conditioning agent.Skin cell can be promoted to grow, inhibit oxygen radical and hydroxyl free Base, promotes the synthesis of stromatin (matrixprotein) especially collagen, while being also possible to increase elastin laminin, thoroughly The generation of bright matter acid, glycosaminoglycan and fibronectin.The synthesis for promoting collagen by increasing stroma cell activity, makes It obtains skin and seems more aobvious elasticity and youth.

One, the preparation of the skin care compositions with senile-resistant efficacy, it is specific as shown in table 1：

Table 1 experimental group 1-6 and control group 1-6

Continued 1

Two, the skin care compositions with senile-resistant efficacy of above-mentioned preparation is applied to embodiment 1-6, comparative example 1-6 In formula：

Embodiment 1

A kind of anti-aging face cream includes the component of following mass percentage：It is the skin care compositions 0.1% of experimental group 1, sweet It is oily polymethacrylates 0.5%, caprylic/capric triglyceride 0.1%, propyloxy phenyl base dimethyl silicone polymer 2%, poly- sweet Oily -10 tristearates 0.1%, butanediol 15%, citric acid 0.01%, carbohydrate isomer 1%, sodium citrate 0.01%, hydroxyethyl cellulose 0.5%, Cremophor RH40 0.01%, aminomethyl propylene glycol 0.5%, yeast β-Portugal are poly- Sugar 0.1%, EDETATE SODIUM 0.05%, rose (ROSARUGOSA) caul-fat 0.0001%, tapioca 0.5%, Sodium Hyaluronate 0.01%, parahydroxyacet-ophenone 0.6%, water surplus.

Embodiment 2

A kind of anti-aging face cream includes the component of following mass percentage：2 skin care compositions 10% of experimental group, glycerine It is polymethacrylates 0.1%, caprylic/capric triglyceride 2%, propyloxy phenyl base dimethyl silicone polymer 0.1%, poly- sweet Oily -10 tristearates 1%, propylene glycol 5%, citric acid 0.1%, carbohydrate isomer 0.1%, sodium citrate 0.1%, hydroxyl Ethyl cellulose 0.1%, Cremophor RH40 0.05%, aminomethyl propylene glycol 0.1%, yeast beta-dextran 3%, EDTA Disodium 0.01%, rose (ROSARUGOSA) caul-fat 0.001%, tapioca 0.1%, Sodium Hyaluronate 0.05%, benzene oxygen second Alcohol 0.2%, water surplus.

Embodiment 3

A kind of anti-aging face cream includes the component of following mass percentage：3 skin care compositions 5% of experimental group, glycerine are poly- Methacrylate 0.3%, caprylic/capric triglyceride 1%, propyloxy phenyl base dimethyl silicone polymer 1%, Natrulon H-10 Tristearate 0.5%, 1,2- pentanediols 10%, citric acid 0.05%, carbohydrate isomer 0.5%, sodium citrate 0.06%, hydroxyethyl cellulose 0.2%, Cremophor RH40 0.03%, aminomethyl propylene glycol 0.3%, yeast β-Portugal are poly- Sugar 1.5%, EDETATE SODIUM 0.03%, rose (ROSARUGOSA) caul-fat 0.0005%, tapioca 0.2%, Sodium Hyaluronate 0.03%, Phenoxyethanol 0.4%, water surplus.

Embodiment 4

A kind of anti-aging face cream includes the component of following mass percentage：4 skin care compositions 3% of experimental group, glycerine are poly- It is methacrylate 0.3%, caprylic/capric triglyceride 0.8%, propyloxy phenyl base dimethyl silicone polymer 1.5%, poly- sweet Oily -10 tristearates 0.6%, 1,2- hexylene glycols 12%, citric acid 0.04%, carbohydrate isomer 0.6%, sodium citrate 0.07%, hydroxyethyl cellulose 0.2%, Cremophor RH40 0.03%, aminomethyl propylene glycol 0.2%, yeast β-Portugal are poly- Sugar 1.8%, EDETATE SODIUM 0.03%, rose (ROSARUGOSA) caul-fat 0.0008%, tapioca 0.4%, Sodium Hyaluronate 0.02%, DMDM hydantoin 0.3%, water surplus.

Embodiment 5

A kind of anti-aging face cream includes the component of following mass percentage：5 skin care compositions 8% of experimental group, glycerine are poly- It is methacrylate 0.4%, caprylic/capric triglyceride 0.3%, propyloxy phenyl base dimethyl silicone polymer 0.7%, poly- sweet Oily -10 tristearates 0.2%, pungent glycol 7%, citric acid 0.06%, carbohydrate isomer 0.4%, sodium citrate 0.07%, hydroxyethyl cellulose 0.3%, Cremophor RH40 0.02%, aminomethyl propylene glycol 0.2%, yeast β-Portugal are poly- Sugar 0.6%, EDETATE SODIUM 0.02%, rose (ROSARUGOSA) caul-fat 0.0005%, tapioca 0.2%, Sodium Hyaluronate 0.03%, preservative 0.3%, water surplus.

Embodiment 6

A kind of anti-aging face cream includes the component of following mass percentage：6 skin care compositions 4% of experimental group, glycerine are poly- It is methacrylate 0.3%, caprylic/capric triglyceride 1.2%, propyloxy phenyl base dimethyl silicone polymer 1.4%, poly- sweet Oily -10 tristearates 0.7%, Sensiva SC50 13%, citric acid 0.06%, carbohydrate isomer 0.3%, citric acid Sodium 0.07%, hydroxyethyl cellulose 0.3%, Cremophor RH40 0.03%, aminomethyl propylene glycol 0.3%, yeast β-Portugal Glycan 2%, EDETATE SODIUM 0.02%, rose (ROSARUGOSA) caul-fat 0.0003%, tapioca 0.4%, Sodium Hyaluronate 0.03%, parahydroxyacet-ophenone 0.4%, water surplus.

Comparative example 1

The difference is that, skin care compositions is control group 1 with embodiment 3.

Comparative example 2

The difference is that, skin care compositions is control group 2 with embodiment 3.

Comparative example 3

The difference is that, skin care compositions is control group 3 with embodiment 3.

Comparative example 4

The difference is that, skin care compositions is control group 4 with embodiment 3.

Comparative example 5

The difference is that, skin care compositions is control group 5 with embodiment 4.

Comparative example 6

The difference is that, skin care compositions is control group 6 with embodiment 4.

1 crease-resistant efficacy assessments of experimental example

Method：Untouchable measurement method FOITS

Subject：Product made from each embodiment selects 30 30-60 Sui women, no serious disease, to cosmetics Without allergies.

Test equipment：Skin fast optical imaging method, abbreviation FOITS.

Test index：The variation of dermatoglyph is quantified by Ra, Rz and FDD standard parameter.Wherein Ra, Rz are skin The parameter of roughness, FDD are depth distribution frequencies.

Test environment requirement：Constant-temperature constant-humidity environment, temperature：22 DEG C ± 1 DEG C, humidity：50% ± 5%.Subject before test It to wait in such circumstances 40 minutes.

Test method：Test position is canthus region, it is desirable that product is smeared uniform.Subject is arranged to use a certain embodiment Product, two canthus area of random arrangement or so uses Unknown Product and standard items respectively, and (it has been known that there is the products of certain anti-wrinkle effect.) Carry out control test；Subject applies once in each daily morning and evening, and service life is 28 days, is 3g-8g per side product dosage.

Test design：Test carries out twice, dividing initial value and eventually last value test altogether.During all product tests, insert Enter one group of standard items and blank control test, subject side test zone uses standard items, and the other side does not smear any product As blank control, compare the result in two regions.It avoids causing since 12 groups of testing time spans of 12 kinds of products are long with this Experimental result deviation.

Statistical method：1, for statistical analysis using statistica7.1 (statsoftcompany, the U.S.) software.System Meter analysis result may determine that apparent wrinkle and the thin variation that wrinkle is compared less close to canthus part, to illustrate that product uses The situation of change of front and back wrinkle.It, also can be to the number of each subject meanwhile in analyzing the ANOVA of canthus area test data According to being analyzed.2, for statistical analysis using statistica7.1 (statsoftcompany, the U.S.) software.First to institute There is initial and end eventually FDD values the being described property statistical analysis of subject and test zone.Non-parametric test method is used for FDD The statistical analysis of value, wherein Wilcoxon- symbols-order-inspection of matched data is used for analysis product and reference standards application The front and back worth significance analysis of skin (test zone) structure (FDD values) initial value and whole end：Mann-WhitneyU- is examined The significance analysis of (Wilcoxon- orders-and inspection) for analyzing the difference between application product and reference standards.

Table 2

By, it is found that the whole last value of embodiment 1-6 products is compared with initial value, Ra, Rz for representing wrinkle profile depth subtract in table 2 It is in significant difference less, product has apparent anti-wrinkle effect；The value last eventually of comparative example 1-4 represents profile depth compared with initial value Ra, Rz of degree do not have significant difference, anti-wrinkle effect unobvious to illustrate hydrolyzed soy fine powder, elastin hydrolysis, soluble egg White polysaccharide, Argireline have synergistic function.

The analysis result of FDD implements the value last eventually of 4-6 products in 12 set products compared with initial value, and wrinkle depth is distributed Fine structure increases and is in significant difference in frequency FDD；The value last eventually of embodiment 1-3 products is compared with initial value, wrinkle Small structure increases and is in significant difference in depth distribution frequency FDD, and coarse structure increases and is in significant difference；Comparison The value last eventually of example 1-4 represents fine structure, small structure, coarse structure in wrinkle depth distribution frequency FDD compared with initial value There is no significant difference, anti-wrinkle effect unobvious.Comparative example 5,6 is with embodiment 4-6 comparisons it is found that red autumnal leaves Malpighia coccigera (MALPIGHIAPUNICIFOLIA) addition of berry extract, palmityl tripeptides -5, which improves, represents wrinkle depth distribution frequency The conspicuousness of fine structure in FDD illustrates red autumnal leaves Malpighia coccigera (MALPIGHIAPUNICIFOLIA) berry extract, palmityl three Peptide -5 has the function of synergy.

Experimental example 2

Detection result on probation is carried out to embodiment 1-6 and comparative example the 1-6 face cream prepared.

Test object：Each experimental group is 20 women (25-50 Sui)；

Test zone：Face area；

It uses：1 time a day, it persistently uses 4 weeks；

Test event：Humidity of skin, the colour of skin be obscure, skin elasticity, the soft degree of skin.Result on trial is shown in Table 3.

Comparative example 1-4 is with embodiment 1-3 comparisons as it can be seen that hydrolyzed soy fine powder, elastin hydrolysis, soluble protein are more Sugar, Argireline, which are face creams, improves that humidity of skin, the colour of skin be obscure, key component of skin elasticity, the soft degree of skin, and water The effect of Essence is just apparent when solution soybean fine powder, elastin hydrolysis, soluble protein polysaccharide, Argireline share, Embody synergistic function.

Embodiment 4-6 is with embodiment 1-3 comparisons as it can be seen that red autumnal leaves Malpighia coccigera (MALPIGHIA PUNICIFOLIA) fruit is extracted The addition of object, palmityl tripeptides -5 significantly improves face cream, and to improve obscure humidity of skin, the colour of skin, skin elasticity, skin soft The effect of degree；And comparative example 5-6 and embodiment 4-6 is compared as it can be seen that red autumnal leaves Malpighia coccigera (MALPIGHIA PUNICIFOLIA) fruit carries Promotion effect can be just embodied when object, palmityl tripeptides -5 being taken to share, and have the function of synergy.

The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.

Claims (7)

1. a kind of polypeptide ageing-resistant skin care composition, which is characterized in that the component containing following parts by weight：Hydrolyzed soy fine powder 0.1-10 parts, 0.1-10 parts of elastin hydrolysis, 0.1-10 parts of soluble protein polysaccharide, 0.1-10 parts of Argireline.

2. skin care compositions according to claim 1, which is characterized in that the skin care compositions also contains following parts by weight Component：0.1-10 parts of red autumnal leaves Malpighia coccigera (MALPIGHIA PUNICIFOLIA) berry extract, palmityl tripeptides -50.1-10 Part.

3. application of the skin care compositions according to claim 1 or 2 in preparing cosmetics, the use of the skin care compositions Amount is the 0.1-10wt% of final products weight.

4. a kind of anti-aging face cream, which is characterized in that include the component of following mass percentage：It is as claimed in claim 1 or 2 Skin care compositions 0.1-10%, glycerine polymethacrylates 0.1-0.5%, caprylic/capric triglyceride 0.1-2%, phenyl Isopropyl dimethyl silicone polymer 0.1-2%, Natrulon H-10 tristearate 0.1-1%, polyalcohol 5-15%, citric acid 0.01-0.1%, carbohydrate isomer 0.1-1%, sodium citrate 0.01-0.1%, hydroxyethyl cellulose 0.1-0.5%, Cremophor RH40 0.01-0.05%, aminomethyl propylene glycol 0.1-0.5%, yeast beta-dextran 0.1-3%, EDTA bis- Sodium 0.01-0.05%, rose (ROSA RUGOSA) caul-fat 0.0001-0.001%, tapioca 0.1-0.5%, hyaluronic acid Sodium 0.01-0.05%, preservative 0.2-0.6%, water surplus.

5. a kind of anti-aging face cream according to claim 4, which is characterized in that the polyalcohol be propylene glycol, butanediol, One or more kinds of mixing in 1,2- pentanediols, 1,2- hexylene glycols, pungent glycol and Sensiva SC50.

6. a kind of anti-aging face cream according to claim 4, which is characterized in that the preservative be DMDM hydantoin, One or more kinds of mixing in parahydroxyacet-ophenone, Phenoxyethanol.

7. a kind of preparation method of anti-aging face cream described in claim 4, which is characterized in that include the following steps：It 1) will power Profit requires skin care compositions, glycerine polymethacrylates, caprylic/capric triglyceride, propyloxy phenyl base described in 1 or 2 poly- Dimethyl siloxane, Natrulon H-10 tristearate are heated to 70-90 DEG C, and stirring and dissolving is spare as oil phase；It 2) will be polynary Alcohol, citric acid, carbohydrate isomer, sodium citrate, hydroxyethyl cellulose, Cremophor RH40, aminomethyl propylene glycol, Yeast beta-dextran, EDETATE SODIUM, rose (ROSA RUGOSA) caul-fat, tapioca, Sodium Hyaluronate, preservative, water heating To 70-90 DEG C, stirring and dissolving is spare as water phase；3) pressurize 0.1-10Mpa, water phase is injected in oil mixture, homogeneous, Homogeneous rate is 1000-5000rpm, insulated and stirred 15-45 minutes after 3-5 minutes；It releases stress, stirs, be cooled to room temperature i.e. It can.