CN114796062B - A composition and a compact anti-aging cosmetic - Google Patents
A composition and a compact anti-aging cosmetic Download PDFInfo
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- CN114796062B CN114796062B CN202210615448.9A CN202210615448A CN114796062B CN 114796062 B CN114796062 B CN 114796062B CN 202210615448 A CN202210615448 A CN 202210615448A CN 114796062 B CN114796062 B CN 114796062B
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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Abstract
The application provides a composition, which comprises Euglena parvula polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate; the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate. The skin care composition provided by the application combines the Euglena gracilis polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate, and combines a specific proportion, and the synergistic effect among the components is utilized to improve the compact anti-aging effect of the composition.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a composition and a compact anti-aging cosmetic.
Background
Modern women have very strict requirements on self-face values, 78% of women are not satisfied with the skin state of themselves, and the requirements on beauty of them are higher and higher, wherein the anti-aging is the most dominant appeal of them, and the proportion of the women in the cosmetic market is improved year by year.
In addition, according to the research report of the Chinese beauty treatment market, the mention rate of the most concerned and warmest maintenance service items of the female 'anti-aging maintenance' in all the items is up to 72.2%, the anti-aging is the skin care effect of the most concerned of consumers, and according to the research, the proportion of Chinese anti-aging cosmetics reaches 23%, so that the anti-aging cosmetics become the first major class.
Skin aging refers to the aging and sexual damage of skin function, and the protective ability, regulation ability and the like of the skin on the body are reduced, so that the skin cannot adapt to the change of internal and external environments, and the overall appearance conditions such as color, form, texture and the like are changed.
Skin aging is a process by which the human body functions or naturally develops rapidly or slowly due to the influence of internal and external factors, mainly due to endogenous aging (time accumulation) and exogenous aging (external exposure to the environment). Endogenous aging is regarded as an irresistible complex natural law, and is mainly characterized by gradual slow down of cell metabolism, gradual loss of collagen, destruction of collagen, imbalance of hormone secretion, initial reduction of fat content, natural apoptosis of partial cells and the like, and is reflected on skin, namely, the skin loses elasticity and luster, is dry and dry to generate wrinkles, and further, melanin deposition, senile plaque acceleration and the like are generated. Exogenous aging is mainly affected by environmental pollution, excessive ultraviolet irradiation, haze, computer blue light irradiation, large working pressure, irregular diet, night, excessive intake of irritant food and other factors.
The disclosed anti-wrinkle products or anti-aging products on the market at present mainly consider the aging factors in the skin, do not comprehensively consider various factors of external factors on aging, have limited anti-aging effect, and cannot meet the anti-wrinkle requirements of consumers.
Thus, there is an urgent need to provide a multiple tightening anti-aging composition that can improve the skin anti-aging effect from the inside out.
Disclosure of Invention
In view of the above, the present application aims to provide a composition having a tightening and anti-aging effect.
The application provides a composition, which comprises Euglena parvula polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate;
the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate.
Preferably, the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 to the hydrolyzed collagen to the sodium polyglutamate is (0.9-3.6), the mass ratio of the Euglena parviflora polysaccharide to the hydrolyzed collagen to the sodium polyglutamate is (0.1-0.3), the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the hydrolyzed collagen is (0.002-0.005), and the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the hydrolyzed collagen is (0.1-0.4).
Preferably, the hydrolyzed collagen has a molecular weight of about 1000Da.
The application provides application of the composition according to any one of the technical schemes in preparation of compact anti-aging cosmetics.
The application provides a tightening anti-aging cosmetic, which comprises the composition according to any one of the technical schemes and auxiliary materials acceptable in the field of cosmetics.
Preferably, in the tightening and anti-aging cosmetic, the addition amount of the composition in any one of the technical schemes is 0.1-6 wt%.
Preferably, the formulation of the cosmetic is one or more of skin cream, skin softening lotion, skin toner, skin tightening lotion, skin lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisturizing cream, hand cream, foundation, essence, nutrition essence, facial mask, soap, facial cleansing foam, facial cleansing lotion, facial cleansing cream, body lotion or body bath lotion.
The application provides multiple tightening anti-aging essence water, which comprises the following components:
the composition according to any one of the technical schemes comprises 0.1-6 wt% wt%, 0.5-wt-8 wt% of humectant, 0.05-wt-0.5-wt% of thickener, 0.5-wt-1.5-wt% of preservative, 0.01-wt-0.1-wt% of chelating agent and 100% of water.
Preferably, the humectant is one or more selected from glycerol, 1, 3-propylene glycol, ethylhexyl glycerol, glycereth-26, inositol, dipropylene glycol, butanediol, erythritol, betaine and sodium hyaluronate;
the thickener is one or more of xanthan gum, small-core fungus glue, carbomer, sodium polyacrylate grafted starch, sodium polyacrylate, polyacrylate crosslinked polymer-6, acrylic acid (ester) copolymer, acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, acrylamide/VP copolymer and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol and octanoyl hydroxamic acid;
the chelating agent is disodium EDTA.
The application provides a preparation method of multiple tightening anti-aging essence, which comprises the following steps:
mixing water, thickener, humectant and chelating agent, heating, stirring, cooling, adding antiseptic, mixing, cooling, adding the components of the composition according to any one of the above technical schemes, and stirring.
Compared with the prior art, the application provides a composition which comprises Euglena parvula polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate; the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate. The skin care composition provided by the application combines the Euglena gracilis polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate, and combines a specific proportion, and the synergistic effect among the components is utilized to improve the compact anti-aging effect of the composition.
Detailed Description
The present application provides a composition and a compact anti-aging cosmetic, and one skilled in the art can suitably modify the process parameters to achieve this by reference to the present disclosure. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and they are intended to be within the scope of the present application. While the methods and applications of this application have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the application can be practiced and practiced with modification and alteration and combination of the methods and applications herein without departing from the spirit and scope of the application.
The application provides a composition, which comprises Euglena parvula polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate;
the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate.
The application provides a composition comprising Euglena parvula polysaccharide.
Euglena parvula, also called euglena gracilis, euglena, contains abundant bioactive substances in cells, such as beta-carotene, vitamin C, vitamin E, beta-1, 3-glucan, polyunsaturated fatty acid and the like; the skin care product can form a fine film on the skin, can form an obvious skin tightening effect on the skin in a very short time, lightens skin fine lines and is softer to use.
The present application provides a composition comprising chicory root extract.
Chicory root extract, originally produced in Europe, is used as a medicinal plant in ancient times, the root of chicory root extract contains oligosaccharides, and a film is formed on the surface of skin, so that the chicory root extract is helpful for the absorption of active substances, and the skin looks shinier and brighter;
the present application provides a composition comprising acetyl hexapeptide-8.
Acetyl hexapeptide-8, which is a neurotransmitter peptide, has the effect similar to botulinum toxin A, and can inhibit the release of the neurotensin acetylcholine to reduce the contraction of muscles, thereby achieving the effect of reducing the generation of dynamic lines and expression lines.
The present application provides a composition comprising hydrolyzed collagen.
The application adopts micromolecule hydrolyzed collagen, preferably 1000Da, to provide necessary nutrient components for skin, supplements various amino acids, and enhances the activity of skin collagen, thereby maintaining the integrity of water and fiber structure of horny layer, having stronger bioactivity and being easier to be absorbed and utilized by skin.
The application provides a composition comprising sodium polyglutamate.
Sodium polyglutamate is a polyamino acid compound formed by crosslinking and bonding L-glutamic acid (L-glutamic acid) and D-glutamic acid (D-glutamic acid) through glutamic acid monomers of alpha-amino and gamma-carboxyl. It is a nontoxic and environmentally and human-friendly amino acid polymer, and the molecular weight of the amino acid polymer is generally between 100kDa and 1000kDa, which is equivalent to about 500-5000 glutamic acid monomers. Gamma-polyglutamic acid has an antioxidant effect in cosmetics and skin care products.
In some preferred embodiments of the application, the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 to the hydrolyzed collagen to the sodium polyglutamate is (0.09-4.5), and the mass ratio of the Euglena parviflora polysaccharide to the hydrolyzed collagen to the sodium polyglutamate is (0.22-2.2), and the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 is (0.0001-0.01), and the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 is (0.1-0.21).
In other embodiments of the application, the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 to the hydrolyzed collagen to the sodium polyglutamate is (0.9-3.6), the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the hydrolyzed collagen to the sodium polyglutamate is (0.44-1.1), the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 to the hydrolyzed collagen is (0.002-0.005), and the mass ratio of the Euglena parviflora polysaccharide to the chicory root extract to the acetyl hexapeptide-8 to the hydrolyzed collagen is (0.15-0.21).
In some embodiments of the present application, the mass ratio of the euglena polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen, and sodium polyglutamate is 0.09:1.8:0.01:0.01:0.1.
In another embodiment of the present application, the mass ratio of the euglena polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen, and sodium polyglutamate is 0.27:2.2:0.003:0.03:0.21.
In one preferred embodiment of the application, the mass ratio of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate is 1.8:0.22:0.002:0.2:0.1.
In one preferred embodiment of the application, the mass ratio of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate is 1.8:0.44:0.01:0.2:0.15.
In one preferred embodiment of the application, the mass ratio of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate is 0.9:1.1:0.01:0.1:0.15.
In one preferred embodiment of the application, the mass ratio of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate is 1.8:0.25:0.0001:0.2:0.15.
In one preferred embodiment of the application, the mass ratio of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate is 4.5:0.44:0.005:0.5:0.2.
The Euglena parvula polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate have more remarkable effects on tightening, anti-aging and ultraviolet resistance when being combined according to the specific mass ratio.
The application provides application of the composition according to any one of the technical schemes in preparation of compact anti-aging cosmetics.
The application provides a tightening anti-aging cosmetic, which comprises the composition according to any one of the technical schemes and auxiliary materials acceptable in the field of cosmetics.
The present application is not limited to the excipients acceptable in the cosmetic field, and those skilled in the art can well know the same.
Preferably, the adjuvants include, but are not limited to, solvents, stabilizers, water, and the like.
In the tightening and anti-aging cosmetic, the addition amount of the composition is preferably 0.1-6. 6wt percent.
In the present application, according to the cosmetic classification principle, cosmetics can be classified into: cleaning cosmetics, nursing cosmetics and beautifying/finishing cosmetics. The cleaning cosmetic is applied to the surface of human body (such as epidermis, hair, nail, lips, etc.) by applying, spraying or other similar methods, and has effects of cleaning and hygiene or eliminating unpleasant odor. The cosmetic is applied to human body surface (such as epidermis, hair, nail, lips, etc.) by applying, spraying or other similar methods. The cosmetic/decorative cosmetic is applied to the surface of human body (such as epidermis, hair, nail, lips, etc.) by painting, spraying or other similar methods, and has effects of caring skin, finishing, and increasing human body charm.
Skin-applicable cleansing cosmetics include: facial cleanser, cleansing water (milk), cleansing cream (honey), facial mask, toilet water, itch powder, talcum powder or bath lotion; skin-applicable care cosmetics include skin cream, lotion or lotion; skin-applicable cosmetic/finishing cosmetics include: powder cake, rouge, eye shadow, eyeliner (liquid), eyebrow pencil, perfume or cologne; hair-applicable cleansing cosmetics include shampoos, creams or shave creams; the hair-suitable care cosmetics include hair conditioner, hair cream, hair oil/wax or hair treatment cream; cosmetic/finishing-type cosmetics for which hair is suitable include: styling mousse/gel, hair dye, permanent wave, mascara solution (cream), hair restorer or depilatory; cleaning cosmetics suitable for nails include nail washing liquid; the care cosmetics suitable for nails comprise nail protection water (cream) and nail hardening agent; nail-applicable make-up/finishing cosmetics include nail polish; the cleansing cosmetic suitable for lips comprises a lip cleansing liquid; lip care cosmetics include lip balm; lip-applicable cosmetic/make-up products include: lipstick, lip gloss or lip pencil.
Alternatively, the composition of the application is formulated into a dosage form for external skin application, in particular a cosmetic or pharmaceutical composition.
Alternatively, the cosmetic composition of the present application may be prepared in any form commonly prepared in the art, and may be, for example, an emulsion, a cream, a lotion, a mask, a foundation, a lotion, a beauty lotion, a hair care product, etc.
Preferably, the cosmetic is one or more of skin cream, skin softening lotion, skin refreshing lotion, skin tightening lotion, skin lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisturizing cream, hand cream, foundation, essence, nutrition essence, facial mask, soap, facial foam, facial cleansing lotion, facial cleansing cream, body lotion or body bath lotion.
The application provides multiple tightening anti-aging essence water, which comprises the following components:
the composition comprises, by weight, 0.1% -6% wt% of the composition, 0.5% -wt% -8 wt% of a humectant, 0.05% -wt% to 0.5wt% of a thickener, 0.5% -wt% to 1.5wt% of a preservative, 0.01% -wt% -0.1% -wt% of a chelating agent and 100% of water.
The multiple tightening anti-aging essence provided by the application comprises 0.1-6-wt% of the composition according to the technical scheme; preferably comprises 1.2wt% to 2.5 wt%.
The above-mentioned compositions of the present application have been clearly described, and will not be described in detail herein.
The multiple tightening anti-aging essence provided by the application comprises 0.5-wt% -8-wt% of humectant; preferably comprises 1wt% to 7 wt%; more preferably, the content is 2-wt% to 6-wt%.
According to the application, the humectant is one or more selected from glycerol, 1, 3-propylene glycol, ethylhexyl glycerol, glycereth-26, inositol, dipropylene glycol, butanediol, erythritol, betaine and sodium hyaluronate.
The multiple tightening anti-aging essence provided by the application comprises 0.05-wt% -0.5-wt% of a thickening agent; preferably comprises 0.1-wt% -0.4-wt%; more preferably, the content is 0.1-wt% -0.3-wt%.
The thickener is one or more of xanthan gum, sclerotium gum, carbomer, sodium polyacrylate grafted starch, sodium polyacrylate, polyacrylate crosslinked polymer-6, acrylic acid (ester) copolymer, acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, acrylamide/VP copolymer and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
the multiple tightening anti-aging essence provided by the application comprises 0.5% -wt% to 1.5% -wt% of preservative; preferably comprises 0.58-wt% -1.4-wt%; more preferably, the content is 1wt% -1.3 wt%.
Specifically, the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol and octanoyl hydroxamic acid.
The multiple tightening anti-aging essence water provided by the application comprises 0.01-wt% -0.1-wt% of chelating agent; preferably comprises 0.02-wt% -0.08-wt%; more preferably, the content is 0.02-wt% to 0.07% by weight.
Optionally, the chelating agent includes, but is not limited to, disodium EDTA.
In a part of the preferred embodiments of the present application, the multiple tightening anti-aging essence water comprises:
according to the technical scheme, the composition comprises 1.2-2.5 wt% of wt%, 1-7-wt% of humectant, 0.1-wt-0.4 wt% of thickener, 0.58-wt-1.4-wt% of preservative, 0.02-wt-0.08-wt% of chelating agent and 100% of water.
The multiple tightening anti-aging essence water prepared finally by the application has better effect through the proportion of the components and the auxiliary agent.
The application provides a preparation method of multiple tightening anti-aging essence, which comprises the following steps:
mixing water, thickener, humectant and chelating agent, heating, stirring, cooling, adding antiseptic, mixing, cooling, adding the components of the composition according to any one of the above technical schemes, and stirring.
The components and the proportions of the multiple tightening anti-aging essence water are clearly described, and are not repeated here.
Firstly, mixing and heating water, a thickening agent, a humectant and a chelating agent, and stirring; the heating is preferably to 80-85 ℃; the stirring is preferably specifically: stirring at 400-800 r/min for 10-15 min to uniformly mix the materials. The temperature is preferably kept for 20-30 min after stirring.
Then cooling to 40-45 ℃; preferably 45 ℃, adding the preservative, and stirring and mixing uniformly.
The application is not limited to the specific manner of stirring, and may be well known to those skilled in the art.
And then cooling to about 35-40 ℃, sequentially adding the components in the multiple tightening anti-aging composition, and discharging after uniform stirring.
The application provides a composition, which comprises Euglena parvula polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate; the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate. According to the skin care composition provided by the application, the fine euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate are combined, so that the skin can absorb a large amount of water, the space between the collagen and other structures in the dermis is filled, the film formed on the skin surface by the chicory root extract can be utilized, the absorption of the composition is promoted, the compactness of cells and the elasticity of the skin are further enhanced, and the synergistic effect among the components is utilized by combining a specific proportion, so that the tightening and anti-aging effect of the composition is improved.
To further illustrate the present application, a composition and a compact anti-aging cosmetic provided by the present application are described in detail below with reference to examples.
The fine euglena polysaccharide and hydrolyzed collagen used in the following examples and comparative examples were purchased from Yuzhi BioStime HP; chicory root extract was purchased from noron under model Tens' Up ™ chicory tirin; acetyl hexapeptide-8 is purchased from federal pharmacy and is of the model BPN-alkyl solution; sodium polyglutamate was purchased from the Yu Huaxi organism under the model Hyafactortm-PGA sodium polyglutamate (PGA-SHM).
Example 1
The embodiment provides essence water with multiple tightening and anti-aging effects, and the formula is as follows:
the preparation method comprises the following steps:
1. heating water, thickener, humectant and chelating agent to 85deg.C, stirring at 500r/min for 15min to mix them uniformly, and maintaining the temperature for 20min;
2. cooling to 45deg.C, adding antiseptic, stirring and mixing;
3. cooling to 40 ℃, sequentially adding the components in the multiple tightening anti-aging composition, and discharging after uniform stirring.
The preparation methods of examples 2 to 7 were the same as those of example 1.
In addition, for the application, comparative examples 1-8 in table 3 are provided, and specific components and contents of the essence water with multiple anti-aging effects in the comparative examples are shown in the following table 3.
Wherein, in comparative example 1, as compared with example 3, the polysaccharide of Euglena gracilis and the hydrolyzed collagen in the multiple tightening and anti-aging composition are equally divided into chicory root extract and glucose rutin; comparative example 2 in comparison with example 3, the other materials were replaced with the Euglena parvula polysaccharide and the hydrolyzed collagen in the composition; comparative example 3 does not contain chicory root extract compared to example 3; comparative example 4 contained only sodium polyglutamate and no other substances as compared with example 3; comparative example 5 contained no acetylhexapeptide-8 and chicory root extract; comparative example 6 other substances in a multiplex tightening anti-aging composition with acetyl hexapeptide-8 and chicory root extract; comparative example 7 and comparative example 8, the ratio range of the composition thereof is out of the range of the present application.
Test example 1 skin seal patch test
The testing method comprises the following steps: 30 panelists were selected, test samples (examples 1 to 7 and comparative examples 1 to 8) were placed in the plaque tester chamber, and one group was selected as a blank, the plaque tester was taped to the forearm of the subject for 24 hours, skin reactions were observed after 48 hours after removal of the plaque tester, skin reaction grading criteria for the skin seal type plaque test are shown in table 4, and specific test results are shown in table 5:
as is clear from the results of the patch test in Table 5, the essence water containing Euglena gracilis polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate has low irritation and high safety.
Test example 2 instant long-acting compaction anti-aging efficacy test
The test method comprises the following steps: one week before the start of the experiment, all subjects were deactivated any skin care product with anti-aging efficacy ingredients; during the test period, the subjects spray a proper amount of the multi-tightening anti-aging essence water according to the application every morning and evening to gently apply massage to the abdomen until absorption, and during the period of 0 to 28 days, the subjects cannot apply any product, including the tested product; before testing, a subject sits still for 30min in a testing environment to enable the skin to reach the most natural state, and takes a photo record by using VISA-CR, and takes a photo record of the face by using VISA-CR after spraying the multi-tightening anti-aging essence water for 5min, and then calculates the wrinkle improvement rate and roughness before and after use by analysis software to reflect the instant improvement condition of the wrinkles of the face by each essence water, namely the instant tightening anti-aging effect.
Long-acting tightening anti-wrinkle test: the test person insists on using the multiple tightening anti-aging essence water 28d according to the present application, and photographs were taken after washing the face at day 28.
A subject: the test persons 160 are randomly divided into sixteen groups, 10 persons are respectively tested in examples 1-7, comparative examples 1-8 and blank control groups, wherein the test persons are good in health condition, free from chronic diseases, nervous system diseases, skin diseases and insensitive skin, free from allergic phenomena to common cosmetics and capable of accurately completing experiments according to regulations.
In the instant tightening anti-aging effect test, the multi-tightening anti-aging essence water prepared in examples 3 to 7 has better instant wrinkle removal effect compared with examples 1 to 7, wherein the improvement rate of skin wrinkles is more than 15%, and the improvement rate of skin roughness is more than 25%; the skin care matrix prepared in example 7 has the best immediate wrinkle removal effect, but since the skin improvement rate of example 3 is also about 15%, example 3 can be selected as the most preferred example based on cost and other factors; wherein, compared with the comparative example 3 and the comparative example 4, q is greater than 1 according to the mean value formula, the synergistic effect of the compositions of the application can be demonstrated, and compared with the comparative example, the synergistic effect of the multiple tightening and anti-aging composition of the application can be demonstrated and the comprehensive effect is better; in the long-acting compact anti-aging test, example 3 is inferior to that of comparative examples 1 to 5 in that the effect is inferior to that of example 3 when any one or more of the components of the multi-compact anti-aging composition of the present application are absent from the comparative examples, while example 3 is inferior to that of comparative examples 7 to 8 in that the composition of the present application is not within the range of the present application, thereby demonstrating that the composition of the present application has a synergistic effect and can exert the maximum effect only within the specific range of the ratio of the present application.
As can be seen from the above table, there is a significant difference (P < 0.05) between examples 1 to 7 and comparative examples 1 to 8;
comparative examples 1 to 6 show significant differences in skin wrinkle improvement and skin roughness compared to example 3, indicating that the synergistic synergy between the compositions of example 3 is produced relative to the compositions lacking a portion of the components.
Compared with comparative examples 7-8, the composition of example 3 has significant advantages, which means that the composition of example 3 has more reasonable proportion compared with the composition with improper proportion, and the synergistic effect of each component is more favorable under the proportion.
Test example 3 protection of HaCaT cells by multiple compact anti-aging essence
The human immortalized keratinocyte HaCaT cells are very similar to the human primary keratinocyte in morphology and biological characteristics, have relatively simple culture conditions and easy proliferation, can be cultured in a large scale and are commonly used for in vitro experiments.
(1) Culturing cells: DMEM medium (containing 10% fetal bovine serum FBS, penicillin 100U/ml, streptomycin 100 μg/ml) was used at 37deg.C with 5% CO 2 Human immortalized keratinocytes (HaCaT cells) were cultured in the incubator of (A), the culture medium was periodically changed, when the cells adhered to the wall of the incubator approximately 90%, the incubator was digested with 0.25% pancreatin digestion solution, and when about 80% of the cells were observed to be suspended by a microscope, the digestion was stopped by adding the culture medium, and the cells were collected by centrifugation at 1000rpm for 5 minutes, and then resuspended in culture medium to a cell density of about 1X10 4 cells/ml。
(2) Protective effect of multiple tightening anti-aging essence water on ultraviolet injury cells
Concentration was 1X10 4 cell suspensions of cells/ml were seeded in 96-well plates as 200. Mu.l/well cell suspension at 37℃in 5% CO 2 Continued incubation in the incubator of (a). After 48h incubation of the cells, the old culture solution was aspirated, 200ul of the multiple tightening anti-aging essence of examples 1-7 and comparative examples 1-8 (blank control group does not contain any component of the multiple tightening anti-aging essence described in the present application, covered with aluminum foil, cell viability was 100%) was added to each well, and the wells were placed at 37℃with 5% CO 2 After a further incubation time of 6 hours, the old culture medium was aspirated, covered with a quartz plate, irradiated with UV light for 20 minutes, fresh culture medium was added, and after a further incubation time of 24 hours, the viability of the cells was measured by MTT.
(3) Cell viability assay using MTT method
Cell viability assay for (2): 20ul of 5mg/ml MTT solution was added per well at 37℃with 5% CO 2 After a further incubation time of 4h, the supernatant was aspirated, 150. Mu.l of DMSO was added to each well and shaken for 10min. The absorbance at 570nm was measured with a microplate reader, and the cell viability was calculated. The results are shown in Table 7.
Cell viability (%) = (OD sample group-OD background)/OD blank group x100%.
Through the ultraviolet ray resistance experiment of Table 7, it was unexpectedly found that the compact anti-aging composition of the present application has a protective effect on ultraviolet ray damaged cells; the experimental result of test example 3 shows that the five compositions of the application complement each other, and the components can protect skin cells, improve the ultraviolet tolerance of the skin and reduce the skin aging caused by photodamage through synergistic effect, thereby achieving the anti-aging effect.
According to the experimental results of the test examples 2 and 3, the composition provided by the application has the immediate tightening and anti-aging effects, has the long-acting tightening and anti-aging effects, and also has the effects of preventing skin injury caused by photo-aging, namely, the skin can be subjected to anti-aging protection from different angles, and meanwhile, only five substances are combined and the maximum synergistic effect can be exerted within a specific proportion range.
The foregoing is merely a preferred embodiment of the present application and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present application, which are intended to be comprehended within the scope of the present application.
Claims (9)
1. A composition comprises Euglena gracilis polysaccharide, herba Cichorii root extract, acetyl hexapeptide-8, hydrolyzed collagen and sodium polyglutamate;
the mass ratio of 0.09-4.5 to 0.22-2.2 to 0.0001-0.01 to 0.01-0.5 to 0.1-0.21 of the euglena polysaccharide, the chicory root extract, the acetyl hexapeptide-8, the hydrolyzed collagen and the sodium polyglutamate;
the molecular weight of the hydrolyzed collagen is 1000Da.
2. The composition according to claim 1, wherein the mass ratio of the fine euglena polysaccharide, chicory root extract, acetyl hexapeptide-8, hydrolyzed collagen, and sodium polyglutamate is (0.9-3.6): (0.1-0.3): (0.002-0.005): (0.1-0.4): (0.07-0.21).
3. Use of a composition according to any one of claims 1 to 2 for the preparation of a compact anti-ageing cosmetic.
4. A compact anti-aging cosmetic comprising a composition according to any one of claims 1 to 2 and a cosmetically acceptable adjuvant.
5. The cosmetic according to claim 4, wherein the composition according to any one of claims 1 to 2 is added in an amount of 0.1 to 6wt% to the compact anti-aging cosmetic.
6. The cosmetic according to claim 4, wherein the cosmetic is in the form of one or more of a skin cream, a skin softening lotion, a skin toner, a skin tightening lotion, a skin lotion, a moisturizing lotion, a nutritional lotion, a massage cream, a nutritional cream, a moisturizing cream, a hand cream, a foundation, a essence, a mask, a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, or a body wash.
7. A multiple tightening anti-aging essence, comprising:
the composition of any one of claims 1-2, 0.1-6 wt%, humectant 0.5-8 wt%, thickener 0.05-0.5 wt%, preservative 0.5-1.5 wt%, chelating agent 0.01-0.1 wt% and water make up 100%.
8. The essence water according to claim 7, characterized in that,
the humectant is one or more selected from glycerol, 1, 3-propylene glycol, ethylhexyl glycerol, glycerol polyether-26, inositol, dipropylene glycol, butanediol, erythritol, betaine and sodium hyaluronate;
the thickener is one or more of xanthan gum, small-core fungus glue, carbomer, sodium polyacrylate grafted starch, sodium polyacrylate, polyacrylate crosslinked polymer-6, acrylic acid (ester) copolymer, acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, acrylamide/VP copolymer and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol and octanoyl hydroxamic acid;
the chelating agent is disodium EDTA.
9. The preparation method of the multiple tightening anti-aging essence water is characterized by comprising the following steps of:
mixing and heating water, a thickening agent, a humectant and a chelating agent, stirring, cooling, adding a preservative, mixing, cooling, adding the components in the composition according to any one of claims 1-2, and stirring.
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