CN110403873A - A kind of anti-wrinkle cream and preparation method thereof - Google Patents
A kind of anti-wrinkle cream and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The embodiment of the invention discloses a kind of anti-wrinkle creams and preparation method thereof, belong to cosmetic technical field.Percentage composition includes following raw material by weight: 9.4~11.4% moisturizer, 16.5~19.5% emollient, 4~7.3% emulsifier, 0.68~0.92% preservative, 0.01~0.03% Argireline; wherein, the moisturizer includes 6.8~7.2 parts of glycerol, 2~3 parts of chicory extracts, 0.3~0.6 part of allantoin, 0.3~0.6 part of Sodium Hyaluronate by weight.The anti-wrinkle cream of the embodiment of the present invention can effectively improve the moistening effect of skin, while have good smoothing wrinkle performance, and with the extension of use time, all have obvious effects on to facial moistening effect and facial dispelling for dynamic line.Each raw material compounding of the invention rationally, stablize by obtained anti-wrinkle cream performance, safe and non-stimulating, can be used for a long time, while anti-wrinkle cream prepares that simple, controllability is good, easily operated, easy to industrialized production.
Description
Technical field
The present embodiments relate to cosmetic technical fields, and in particular to a kind of anti-wrinkle cream and preparation method thereof.
Background technique
Wrinkle is the initial sign of skin aging.In general, start within women 30-35 years old wrinkle occur, male is in 35-40
Year starts wrinkle occur.Earliest occur wrinkle position be 1/3 on face at, first position for wrinkle occur is the fish on the outside of eye
Tail line；Followed by forehead line and glabella line；It is again line on Nasolabial furrow wrinkles under face and lip；The neck finally occurred stretches the neck width of side
Flesh line.The appearance of wrinkle significantly allows people to feel that aging has been come, and has brought stress.
Existing smoothing wrinkle method: using botulinum toxin type A, be usually injected at around wrinkle, treats the mechanism of wrinkle
It is, facial expression muscle terminates in skin, and when contraction directly affects skin, and the contraction repeatedly of these mimetic muscles is dynamic property skin wrinkle
The major reason that line generates.Creotoxin reaches the work for the treatment of wrinkle by the contraction of block nerves muscle conduction, inhibition muscle
With.With rapid-action, effect clear advantage, but because of the cost of its usage mode (must inject) and valuableness, allows and commonly disappear
Expense person keeps someone at a respectful distance.
The external use skin care or cosmetics that anti-wrinkle cream refers to the prevention for wrinkle and dispels have easy to use, price phase
To cheap advantage.
Argireline is a kind of biologically active polypeptide, by inhibiting the release of neurotransmitter acetylcholine, to reduce
The contraction of muscle, to reach the generation for reducing dynamic line, expression line.It can not only reduce existing facial wrinkles, but also can be effective
Prevent new wrinkle from generating.The effect of Argireline, can match in excellence or beauty with botulinum toxin type A, while have different from A type meat
The anesthesia mechanism of toxin, can make muscle proper motion and expression, not generate other side effects, and avoid A type meat poisoning again
Toxin must inject the disadvantage high with use cost.Therefore, develop it is a kind of using Argireline as core it is crease-resistant at
The anti-wrinkle cream divided has very positive meaning.
Summary of the invention
For this purpose, the embodiment of the present invention provides a kind of anti-wrinkle cream and preparation method thereof, it is existing using botulinum toxin type A to solve
It carries out that the disadvantage high with use cost must be injected existing for smoothing wrinkle.
To achieve the goals above, the embodiment of the present invention provides the following technical solutions:
According to a first aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of anti-wrinkle cream, the anti-wrinkle cream is pressed
Weight percentage includes following raw material: 9.4~11.4% moisturizer, 16.5~19.5% emollient, 4~7.3%
Emulsifier, 0.68~0.92% preservative, 0.01~0.03% Argireline, wherein the moisturizer is by weight
Part includes 6.8~7.2 parts of glycerol, 2~3 parts of chicory extracts, 0.3~0.6 part of allantoin, 0.3~0.6 part of Sodium Hyaluronate.
Further, the emollient include by weight 4.5~5.5 parts of olive oil, 5.5~6.5 portions of wheat-germ oils,
6.5~7.5 parts of grape seed oils.
Further, the emulsifier include by weight 0.8~1.2 part of alkyl phosphate triethanolamine salt, 0.4~
0.8 part of stearic acid, 1.8~2.3 parts of octadecyl alcolols, 1~3 part of glycerin monostearate.
Further, the preservative includes 0.08~0.12 part of potassium sorbate, 0.6~0.8 part of PE9010 by weight.
According to a second aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of preparation method of anti-wrinkle cream, institutes
State method the following steps are included:
S1: stearic acid, octadecyl alcolol, glycerin monostearate are placed in container A, are heated and are stirred, until dissolution, mixing
Uniformly, olive oil, wheat-germ oil and grape seed oil is then added, keeps identical temperature to continue to stir, is uniformly mixed again,
Obtain oily phase；
S2: deionized water, glycerol, alkyl phosphate triethanolamine salt are placed in container B, heats and stirs evenly, obtain
To water phase；
S3: the oil is mutually added in emulsifier carries out homogeneous simultaneously with water phase；
S4: material carries out cooling processing after homogeneous, and allantoin, Sodium Hyaluronate, Argireline and chrysanthemum is then added
Lettuce extract, stirs evenly, and is eventually adding potassium sorbate and PE9010, is again stirring for uniformly, room temperature to be down to can spout bag
Dress.
Further, in step S1 and step S2, heating temperature is 75~80 DEG C.
Further, in step S3, homogenizing time is 3~5min.
Further, in step S4, the cooling processing refers to is down to 45~50 DEG C under agitation, and urine is then added
Bursin, Sodium Hyaluronate, Argireline and chicory extract, mixing time are 10~20min, are eventually adding potassium sorbate
And PE9010, being again stirring for the time is 5~10min.
Further, the weight percentage of each substance are as follows: glycerol 6.8~7.2%, chicory extract are 2~3%, urinate
Bursin 0.3~0.6%, Sodium Hyaluronate 0.3~0.6%, olive oil 4.5~5.5%, wheat-germ oil 5.5~6.5%, Portugal
Grape seed oil 6.5~7.5%, alkyl phosphate triethanolamine salt 0.8~1.2%, stearic acid 0.4~0.8%, octadecyl alcolol 1.8~
2.3%, glycerin monostearate 1~3%, potassium sorbate 0.08~0.12%, PE9010 0.6~0.8%, acetyl group hexapeptide-
8 0.01~0.03%, surplus is deionized water.
INCI title/the English name for each raw material that the embodiment of the present invention uses is as follows:
| Glycerol | GLYCERIN |
| Chicory extract | CICHORIUM INTYBUS EXTRACT |
| Allantoin | ALLABNTOIN |
| Sodium Hyaluronate | HYALURONIC ACID |
| Olive oil | OLIVE OIL |
| Wheat-germ oil | WHEATGERM OIL |
| Grape seed oil | GRAPESEED OIL |
| Allantoin | ALLABNTOIN |
| Stearic acid | STEARIC ACID |
| Octadecyl alcolol | STEARYL ALCOHOL |
| Glycerin monostearate | GLYCEROL MONOSTEARATE |
| Potassium sorbate | POTASSIUM SORBATE |
| PE9010 | PHENOXYETHANOL(AND)ETHYLHEXYLGLYCERIN |
| Argireline | REPROAGE |
| Methyl p-hydroxybenzoate | METHYLPARABEN |
Chicory extract has excellent antioxidant and moisture retention, and delaying sanility has certain absorption to ultraviolet light, has
There is certain anti-inflammatory power.For facial cosmetics moisturizing and prevent skin ageing, dim skin, antioxygen can be effectively improved
Change, delay senescence, moisturizing keeps skin water profit glossy, reappears skin vigor, while being effective against inflammation.
The embodiment of the present invention has the advantages that
The present invention compounds the moisturizer comprising chicory extract, moisturizing using Argireline as smoothing wrinkle core component
Agent, emulsifier, preservative have obtained the anti-wrinkle cream of the embodiment of the present invention, which can effectively improve the moistening effect of skin,
There is good smoothing wrinkle performance simultaneously, and with the extension of use time, dispels to facial moistening effect and facial dynamic line
Except all having obvious effects on.
Each raw material compounding of the invention rationally, is stablized by obtained anti-wrinkle cream performance, safe and non-stimulating, can be used for a long time, together
When anti-wrinkle cream prepare that simple, controllability is good, easily operated, it is easy to industrialized production.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily, it is clear that described embodiment is the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
Embodiment 1
The anti-wrinkle cream of the present embodiment, including following raw material: glycerol, chicory extract, allantoin, Sodium Hyaluronate, olive
Oil, wheat-germ oil, grape seed oil, alkyl phosphate triethanolamine salt, stearic acid, octadecyl alcolol, glycerin monostearate, sorb
Sour potassium, PE9010, Argireline and deionized water.The weight percentage of above each raw material is shown in Table 1.
Preparation method includes the following steps:
S1: stearic acid, octadecyl alcolol, glycerin monostearate are placed in container A, are heated to 80 DEG C and are stirred, until molten
Solution is uniformly mixed, and olive oil, wheat-germ oil and grape seed oil is then added, and is kept for 80 DEG C and is continued to stir, and mixing is equal again
It is even, obtain oily phase；
S2: deionized water, glycerol, alkyl phosphate triethanolamine salt are placed in container B, are heated to 75 DEG C and are stirred equal
It is even, obtain water phase；
S3: the oil is mutually added in emulsifier carries out 3~5min of homogeneous simultaneously with water phase；
S4: the material after homogeneous is down to 45 DEG C under agitation, and allantoin, Sodium Hyaluronate, acetyl group is then added
Hexapeptide -8 and chicory extract stir 15min, are eventually adding potassium sorbate and PE9010, are again stirring for 10min, room to be down to
Temperature, can discharge packaging.
Embodiment 2-6
The anti-wrinkle cream of embodiment 2-6 difference from example 1 is that, the weight percentage of each raw material is different, tool
Body proportion relation is shown in Table 1.
Table 1
Comparative example 1
The anti-wrinkle cream of this comparative example is difference from example 1 is that contained moisturizer is different, this comparative example is by chrysanthemum
Lettuce extract is substituted for the glycerol of equivalent.
Test case 1
Physicochemical property test
Anti-wrinkle cream made from 1-6 of the embodiment of the present invention is the white shape body of white, pH value 5.5-6.5.
Heat resistant test: taking two parts of samples, and a copy of it is placed in the electro-heating standing-temperature cultivator that temperature is (40 ± 1) DEG C and is protected
It after holding for 24 hours, takes out, is compared after restoring room temperature with another sample, observe whether it has thinning, discoloration, layering and hard
Phenomena such as degree variation.
Low temperature resistant test: taking two parts of samples, and a copy of it is placed in the refrigerator that temperature is (- 10 ± 1) DEG C and is kept for 24 hours
Afterwards, it takes out, is compared after restoring room temperature with another sample, observe whether it has thinning, discoloration, layering and firmness change
Phenomena such as.
After tested, the anti-wrinkle cream of 1-6 of the embodiment of the present invention does not occur thinning, discoloration, layering in heat-resisting low temperature resistant test
And phenomena such as firmness change.It can be seen that the anti-wrinkle cream performance of the embodiment of the present invention is stablized, meet professional standard according to industry
The regulation of standard QB/T 1857-2013 moisturizing cream.
Test case 2
Security test
Referring to GB 17149.1-1997 " cosmetic dermatosis diagnostic criteria and treatment principle general provisions " to embodiment 1-6 system
The anti-wrinkle cream obtained carries out human body patch test, and 30 people of subject is randomly divided into 6 groups, and every group of 5 people, every group of subject uses respectively
Anti-wrinkle cream made from embodiment 1-6.
Anti-wrinkle cream sample is put into spot tester, control wells are that blank does not smear any substance.By anti-wrinkle cream sample and sky
White control is pasted on subject's forearm song side with non-stimulated adhesive tape, keeps for 24 hours.30min after removal spot tester, observation skin are anti-
It answers, observes a dermoreaction after patch test again respectively with 48h for 24 hours.Skin adverse reaction grading standard is shown in Table 2.
Table 2
All subjects 30min after removing spot tester is for 24 hours feminine gender with 48h Skin observing result, illustrates the present invention
The anti-wrinkle cream of embodiment is nonirritant to human skin.
Test case 3
Efficacy assessments test
According to the voluntary behavior of volunteer, 30~35 years old young people of 70 skin healths is chosen as subject.By
Examination person's health, without skin medical history and cosmetic allergic contact dermatitis history.All subjects are randomly divided into test 1-6 group and control
Group, every group of 10 people, respectively accordingly using embodiment 1-6 and the anti-wrinkle cream of comparative example 1.
2~3 days before testing, the recipient site (face) of subject must not use any cosmetics and drug articles, In
It tests preceding 1 hour, subject needs clean position to be tested, before test, needs to stablize under conditions of test
At least 30min, dduring test, subject can not feed, drink water, strenuous exercise, also unusable mutually similar dduring test
The skin-protection product of type.Test environment: 20~25 DEG C of temperature, relative humidity (RH) 50%.
Subject uses about 2g sample in face sooner or later daily, uniformly smears, before the test, 10d, 20d of test,
30d carries out keratoderma moisture determination respectively, and inquires subject's symptom and subjective assessment.
1, the measurement of water content of stratum corneum: with Comeometer CM825 moisture measurement probe test subject's facial markers
Before the use of region, use the variation of the water content in rear 10d, 20d, 30d keratoderma.The keratoderma of each group subject
The test result of water content is shown in Table 3.
Table 3
As shown in Table 3, for test 1-6 group when using 10d, 20d and 30d, water content of stratum corneum is above control group.With
Using the extension of time, compared with the basic value before using, the water content of stratum corneum for testing 1-6 group and control group is increased
Add, and the increasing degree for testing 1-6 group is greater than control group.It is preferable to illustrate that the anti-wrinkle cream of the embodiment of the present invention has compared with comparative example
Water holding capacity.
2, subjects subjective evaluates: each group subject is when being used continuously 10d, 20d, 30d to skin tightness, table
Face quality, wrinkle, facial appearance etc. carry out self-assessment.
Self-assessment standard is as follows:
Excellent: skin of face is compact flexible, and facial dynamic wrinkle obviously disappears；
Good: skin of face is more resilient, and facial dynamic line significantly reduces；
Good: facial dynamic line lightens；
Difference: with data comparison before without any significant change, facial dynamic line is not any change.
The self-assessment of each group subject the results are shown in Table 4.
Table 4
As shown in Table 4, test the subject of 1-6 group when 10d, 20d is used continuously, self-assessment grade to be excellent, good and
Good total number of persons is more than control group, and when 30d is used continuously, self-assessment grade is that excellent and good total number of persons is more than control
Group.
With the extension of use time, when 30d is used continuously, most subject's skin of face of 1-6 group are tested
Flexible, facial dynamic line significantly reduces, illustrate the anti-wrinkle cream of the embodiment of the present invention under the premise of mitigating facial dynamic wrinkle,
Preferable moisturizing is provided to skin simultaneously to act on.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (9)
1. a kind of anti-wrinkle cream, which is characterized in that anti-wrinkle cream percentage composition by weight includes following raw material: 9.4~11.4%
Moisturizer, 16.5~19.5% emollient, 4~7.3% emulsifier, 0.68~0.92% preservative, 0.01~
0.03% Argireline, wherein the moisturizer includes 6.8~7.2 parts of glycerol, 2~3 parts of witloofs extractions by weight
Object, 0.3~0.6 part of allantoin, 0.3~0.6 part of Sodium Hyaluronate.
2. anti-wrinkle cream according to claim 1, which is characterized in that the emollient includes 4.5~5.5 parts of olives by weight
Olive oil, 5.5~6.5 portions of wheat-germ oils, 6.5~7.5 parts of grape seed oils.
3. anti-wrinkle cream according to claim 1, which is characterized in that the emulsifier includes 0.8~1.2 part of alkane by weight
Base phosphate triethanolamine salt, 0.4~0.8 part of stearic acid, 1.8~2.3 parts of octadecyl alcolols, 1~3 part of glycerin monostearate.
4. anti-wrinkle cream according to claim 1, which is characterized in that the preservative includes 0.08~0.12 part by weight
Potassium sorbate, 0.6~0.8 part of PE9010.
5. a kind of preparation method of anti-wrinkle cream, which is characterized in that the described method comprises the following steps:
S1: stearic acid, octadecyl alcolol, glycerin monostearate are placed in container A, are heated and are stirred, until dissolution, mixing is equal
It is even, olive oil, wheat-germ oil and grape seed oil is then added, keeps identical temperature to continue to stir, is uniformly mixed again, obtain
To oily phase；
S2: deionized water, glycerol, alkyl phosphate triethanolamine salt are placed in container B, heats and stirs evenly, obtain water
Phase；
S3: the oil is mutually added in emulsifier carries out homogeneous simultaneously with water phase；
S4: material carries out cooling processing after homogeneous, and allantoin, Sodium Hyaluronate, Argireline and witloof is then added and mentions
Object is taken, is stirred evenly, potassium sorbate and PE9010 are eventually adding, is again stirring for uniformly, room temperature to be down to, can discharge packaging.
6. the preparation method of anti-wrinkle cream according to claim 5, which is characterized in that in step S1 and step S2, heating temperature
Degree is 75~80 DEG C.
7. the preparation method of anti-wrinkle cream according to claim 5, which is characterized in that in step S3, homogenizing time be 3~
5min。
8. the preparation method of anti-wrinkle cream according to claim 5, which is characterized in that in step S4, the cooling processing is
Finger is down to 45~50 DEG C under agitation, and allantoin, Sodium Hyaluronate, Argireline and witloof is then added and extracts
Object, mixing time are 10~20min, are eventually adding potassium sorbate and PE9010, and being again stirring for the time is 5~10min.
9. the preparation method of anti-wrinkle cream according to claim 5, which is characterized in that the weight percentage of each substance are as follows:
Glycerol 6.8~7.2%, chicory extract are 2~3%, allantoin 0.3~0.6%, Sodium Hyaluronate 0.3~0.6%, olive
Oily 4.5~5.5%, wheat-germ oil 5.5~6.5%, grape seed oil 6.5~7.5%, alkyl phosphate triethanolamine salt 0.8
~1.2%, stearic acid 0.4~0.8%, octadecyl alcolol 1.8~2.3%, glycerin monostearate 1~3%, potassium sorbate 0.08~
0.12%, PE9010 0.6~0.8%, Argireline 0.01~0.03%, surplus are deionized water.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112057391A (en) * | 2020-10-22 | 2020-12-11 | 南京泛成生物科技有限公司 | Moisturizing cream and preparation method thereof |
| CN114796062A (en) * | 2022-06-01 | 2022-07-29 | 广州睿森生物科技有限公司 | Composition and firming and anti-aging cosmetic |
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| EP3466406A1 (en) * | 2016-05-24 | 2019-04-10 | Natura Cosméticos S.A. | Anti-wrinkle cosmetic composition, composition system and method for cosmetic skin treatment |
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| CN114796062A (en) * | 2022-06-01 | 2022-07-29 | 广州睿森生物科技有限公司 | Composition and firming and anti-aging cosmetic |
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