JP2014208597A - Increasing agent for ceramide content in nail - Google Patents
Increasing agent for ceramide content in nail Download PDFInfo
- Publication number
- JP2014208597A JP2014208597A JP2013086056A JP2013086056A JP2014208597A JP 2014208597 A JP2014208597 A JP 2014208597A JP 2013086056 A JP2013086056 A JP 2013086056A JP 2013086056 A JP2013086056 A JP 2013086056A JP 2014208597 A JP2014208597 A JP 2014208597A
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- JP
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- Prior art keywords
- extract
- acid
- nail
- oil
- plant
- Prior art date
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- 235000019155 vitamin A Nutrition 0.000 description 1
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- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
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- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
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- 229960002675 xylitol Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
Description
本発明は、新規な爪のセラミド含量剤に関するものである。本発明は、食品、ネイルケア化粧品等に広く利用される。 The present invention relates to a novel nail ceramide content agent. The present invention is widely used for foods, nail care cosmetics and the like.
ポリアミンは、第1級アミノ基を2つ以上もつ脂肪族炭化水素の総称で生体内に普遍的に存在する天然物であり、20種類以上が見いだされている。代表的なポリアミンとしてはプトレシン、スペルミジン、スペルミンがある。ポリアミンの主な生理作用としては(1)核酸との相互作用による核酸の安定化と構造変化(2)種々の核酸合成系への促進作用(3)タンパク質合成系の活性化(4)細胞膜の安定化や物質の膜透過性の強化(5)活性酸素の消去(6)細胞増殖の促進(7)抗アレルギー作用が知られている。 Polyamine is a general term for aliphatic hydrocarbons having two or more primary amino groups, and is a natural product that exists universally in the living body, and more than 20 types have been found. Typical polyamines include putrescine, spermidine and spermine. The main physiological functions of polyamines are as follows: (1) Stabilization and structural changes of nucleic acids by interaction with nucleic acids (2) Promotion of various nucleic acid synthesis systems (3) Activation of protein synthesis systems (4) Cell membrane Stabilization and enhancement of membrane permeability of substances (5) elimination of active oxygen (6) promotion of cell growth (7) anti-allergic action is known.
また、爪は、爪甲,爪母,爪郭,爪床からなる角化性の上皮組織であり、爪母は爪甲(いわゆる爪の部分)のケラチノサイトの発生部位である。この部位で分化増殖したケラチノサイトが外側へ伸びて角化することにより、爪甲が形成される。
爪甲の強度は爪甲の厚みと曲がり具合の程度により決定され、厚みがあるほど丈夫で、また適度に曲がっていることで,外力に対応する力を持つことが知られている。
また、爪の脂質の約15 %はセラミドで構成されており、爪の水分維持に重要な役割を果たしている。
The nail is a keratinized epithelial tissue composed of the nail plate, nail mother, nail cage, and nail bed, and the nail mother is a site where keratinocytes are generated on the nail plate (so-called nail part). The keratinocytes differentiated and proliferated at this site extend outward and keratinize to form a nail plate.
The strength of the nail plate is determined by the thickness of the nail plate and the degree of bending. It is known that the thickness of the nail plate is stronger and stronger, and has a strength corresponding to external force by being bent appropriately.
In addition, about 15% of nail lipids are composed of ceramide and play an important role in maintaining nail moisture.
このような背景の下、植物由来のポリアミン組成物において、爪に含まれるセラミドの含有量を増加させることを本発明者は見出し、本発明を完成させた。
即ち、本発明は上記課題を解決するためになされたものであり、ポリアミンの新規な用途を提供することを目的とする。
Under such a background, the present inventors have found that the content of ceramide contained in the nail is increased in the plant-derived polyamine composition, and the present invention has been completed.
That is, the present invention has been made to solve the above-described problems, and an object thereof is to provide a novel use of polyamine.
上記課題を解決するための本発明の特徴は、以下の通りである。
(1)植物及び/または植物加工物由来のポリアミン組成物を有効成分とする爪におけるセラミド含量増加剤。
(2)物及び/または植物加工物由来のポリアミン組成物を有効成分とする爪における水分蒸散量抑制剤。
(3)上記植物はイネの胚芽であることを特徴とする上記(1)または上記(2)の剤。
The features of the present invention for solving the above-described problems are as follows.
(1) A ceramide content increasing agent in a nail comprising a polyamine composition derived from a plant and / or a processed plant product as an active ingredient.
(2) A moisture transpiration inhibitor for nail containing a polyamine composition derived from a product and / or processed plant product as an active ingredient.
(3) The agent according to (1) or (2) above, wherein the plant is rice germ.
以下、本発明を詳細に説明する。
本発明は植物及び/または植物加工物由来のポリアミン組成物を有効成分とすることを特徴とする。
本発明において「植物及び/または植物加工物」とは、種々の植物或いは植物を加工した物であり、特に限定されるものではないが、例えば双子葉植物、単子葉植物、草本性植物、木本性植物、ウリ科植物、ナス科植物、イネ科植物、アブラナ科植物、マメ科植物、アオイ科植物、キク科植物、アカザ科植物、マメ科の植物、該植物加工物、該植物エキスなどが挙げられる。例えば、サツマイモ、トマト、キュウリ、カボチャ、メロン、スイカ、タバコ、シロイヌナズナ、ピーマン、ナス、マメ、サトイモ、ホウレンソウ、ニンジン、イチゴ、ジャガイモ、イネ、トウモロコシ、アルファルファ、小麦、オオムギ、ダイズ、ナタネ、ソルガム、ユーカリ、ポプラ、ケナフ、杜仲、サトウキビ、シュガービート、キャッサバ、サゴヤシ、アカザ、ユリ、ラン、カーネーション、バラ、キク、ペチュニア、トレニア、キンギョソウ、シクラメン、カスミソウ、ゼラニウム、ヒマワリ、シバ、ワタ、エノキダケ、ホンシメジ、マツタケ、シイタケ、キノコ類、チョウセンニンジン、アガリクス、ウコン、オタネニンジン、柑橘類、緑茶、紅茶、ウーロン茶、バナナ、キウイ、納豆、豆乳、ダイズエキス、小麦エキス、胚芽エキス、胚エキス、果汁、オカラ、コメ胚芽、小麦胚芽、オオムギ胚芽、ダイズ胚芽、トウモロコシ胚芽、マイロ胚芽、ヒマワリ胚芽などが挙げられる。
好ましくは、単子葉植物や双子葉植物がよく、さらに好ましくはイネ科植物やマメ科植物がよく、特に好ましくは、トウモロコシ、キノコ類、ダイズ、小麦、イネ、納豆、豆乳、オカラ、小麦胚芽、ダイズ胚芽、トウモロコシ胚芽、ダイズエキス、小麦エキス、胚芽エキス、胚エキスがよい。特に国民一人・1年当たり供給純食料が多い植物、例えば、大豆、イネ、小麦などからポリアミンを回収してもよい。
Hereinafter, the present invention will be described in detail.
The present invention is characterized by comprising a polyamine composition derived from a plant and / or a plant processed product as an active ingredient.
In the present invention, “plants and / or processed plant products” are various plants or processed products of plants, and are not particularly limited. For example, dicotyledonous plants, monocotyledonous plants, herbaceous plants, trees Natural plant, Cucurbitaceae plant, Solanum plant, Gramineae plant, Brassicaceae plant, Legume plant, Mallow plant, Asteraceae plant, Rabbitaceae plant, Legume plant, processed plant product, plant extract, etc. Can be mentioned. For example, sweet potato, tomato, cucumber, pumpkin, melon, watermelon, tobacco, Arabidopsis, pepper, eggplant, bean, taro, spinach, carrot, strawberry, potato, rice, corn, alfalfa, wheat, barley, soybean, rapeseed, sorghum, Eucalyptus, poplar, kenaf, Tochu, sugar cane, sugar beet, cassava, sago palm, red pepper, lily, orchid, carnation, rose, chrysanthemum, petunia, torenia, snapdragon, cyclamen, gypsophila, geranium, sunflower, shiba, cotton, enoki mushroom , Matsutake, Shiitake, Mushrooms, Ginseng, Agaricus, Turmeric, Panax ginseng, Citrus, Green tea, Black tea, Oolong tea, Banana, Kiwi, Natto, Soy milk, Soybean extract, Wheat extract, Germ Kiss, embryo extract, fruit juice, Ocala, rice germ, wheat germ, barley germ, soybean germ, corn germ, milo germ, such as sunflower germ, and the like.
Preferred are monocotyledonous plants and dicotyledonous plants, more preferably grasses and legumes, and particularly preferably maize, mushrooms, soybeans, wheat, rice, natto, soy milk, okara, wheat germ, Soybean germ, corn germ, soybean extract, wheat extract, germ extract and embryo extract are preferred. In particular, polyamines may be recovered from plants, such as soybeans, rice, and wheat, which have a large net supply of food per person per year.
ポリアミン組成物を回収する植物組織としては、特に限定はされない。好ましくは、種子形態、生育過程にあるものである。生育過程にある植物は全体、あるいは部分的な組織から回収することができる。回収できる部位としては、特に限定されないが全樹、花、蕾、子房、果実、葉、子葉、茎、芽、根、種子、乾燥種子、胚、胚芽、根などである。好ましくは、果実、葉、茎、芽、種子、乾燥種子、胚芽、胚であり、特に好ましくは、種子、乾燥種子、胚芽、胚などである。これらのうち特に大豆胚芽、イネの胚芽及び小麦の胚芽のうちの少なくとも1種を用いることが好ましい。 The plant tissue for recovering the polyamine composition is not particularly limited. Preferably, the seed is in the form of seed or growth process. Plants in the process of growing can be recovered from whole or partial tissues. Although it does not specifically limit as a site | part which can be collect | recovered, a whole tree, a flower, a cocoon, an ovary, a fruit, a leaf, a cotyledon, a stem, a bud, a root, a seed, a dry seed, an embryo, an embryo, a root, etc. Preferred are fruits, leaves, stems, buds, seeds, dried seeds, embryos, embryos, and particularly preferred are seeds, dried seeds, germs, embryos, and the like. Among these, it is particularly preferable to use at least one of soybean germ, rice germ and wheat germ.
植物及び/又は植物加工物由来のポリアミン組成物は以下の方法にて製造することができる。
即ち、植物及び/又は植物加工物を酸性条件下に処し、その後、液体画分を分離することにより植物由来のポリアミンの組成物を得ることができる。
A polyamine composition derived from a plant and / or a processed plant product can be produced by the following method.
That is, a plant-derived polyamine composition can be obtained by treating plants and / or processed plant products under acidic conditions, and then separating the liquid fraction.
ここで、「酸性条件下」とは、pHが6以下の条件をいう。精製時に、pHを酸性条件下にすることにより、植物組織から効率的かつ安定的なポリアミン組成物回収の効果が得られる。この効果は、pHが6以下であれば一様に得られるが、好ましくはpHが6〜3であり、特に好ましくはpHが4.5〜3.5である。 Here, “under acidic conditions” refers to conditions under which the pH is 6 or less. By effecting the pH under acidic conditions during purification, an efficient and stable polyamine composition recovery effect can be obtained from plant tissue. This effect can be obtained uniformly if the pH is 6 or less, but preferably the pH is 6 to 3, particularly preferably 4.5 to 3.5.
本願発明の「植物加工物」とは植物から得られる物又はその加工物をいう。その調製方法とは、植物を水、有機溶媒、水と有機溶媒の混合物などを用いて、低温、室温、加温条件下での含浸法、蒸留法、圧搾法、超音波法、超臨界流体法、亜臨界流体法などで抽出物を回収する。さらに植物や植物から回収した抽出物を発酵させるなどの加工処理した加工物なども含まれる。例えば植物エキス、豆乳、オカラ、小麦粉、発酵エキス、納豆などが挙げられる。 The “processed plant product” of the present invention refers to a product obtained from a plant or a processed product thereof. The preparation method is impregnation method under low temperature, room temperature and warm condition using water, organic solvent, mixture of water and organic solvent, distillation method, pressing method, ultrasonic method, supercritical fluid The extract is recovered by the method or subcritical fluid method. Furthermore, the processed material etc. which fermented the extract collect | recovered from the plant and the plant are included. For example, plant extracts, soy milk, okara, wheat flour, fermented extract, natto and the like can be mentioned.
酸性条件下になるように添加する酸溶液としては、塩酸、硫酸、リン酸などの鉱酸、酢酸、プロピオン酸、酪酸、蓚酸、マロン酸、コハク酸、フマル酸、マレイン酸、リンゴ酸、乳酸、酒石酸、クエン酸、安息香酸などの有機酸および酸性水が挙げられるが、0.01N〜6Nの塩酸、硫酸、硝酸、酢酸、リン酸、トリクロロ酢酸、スルホサリチル酸、ギ酸、クエン酸、乳酸や0.1〜10%の過塩素酸などの無機酸や有機酸などである。 Acid solutions to be added under acidic conditions include mineral acids such as hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, butyric acid, succinic acid, malonic acid, succinic acid, fumaric acid, maleic acid, malic acid, lactic acid Organic acids such as tartaric acid, citric acid, benzoic acid and acidic water, but 0.01N to 6N hydrochloric acid, sulfuric acid, nitric acid, acetic acid, phosphoric acid, trichloroacetic acid, sulfosalicylic acid, formic acid, citric acid, lactic acid, Inorganic acids such as 0.1 to 10% perchloric acid and organic acids.
また、植物及び/又は植物加工物に含まれていたポリアミンを酸溶液中(液体画分)に十分に抽出した後に遠心分離や濾過分離によって液体画分を残査や沈殿と分離する。回収された液体画分にはポリアミンが多く含まれており「ポリアミン組成物」として得た。 Further, after sufficiently extracting the polyamine contained in the plant and / or plant processed product into the acid solution (liquid fraction), the liquid fraction is separated from the residue and precipitate by centrifugation or filtration separation. The recovered liquid fraction contained a large amount of polyamine and was obtained as a “polyamine composition”.
本発明において「ポリアミン」とは、第1級アミノ基を2つ以上もつ脂肪族炭化水素の総称で生体内に普遍的に存在する天然物であり、20種類以上のポリアミンが見いだされている。例えば、1,3−ジアミノプロパン、プトレシン、カダベリン、カルジン、スペルミジン、ホモスペルミジン、アミノプロピルカダベリン、テルミン、スペルミン、テルモスペルミン、カナバルミン、アミノペンチルノルスペルミジン、N,N−ビス(アミノプロピル)カダベリン、ホモスペルミン、カルドペンタミン、ホモカルドペンタミン、カルドヘキサミン、ホモカルドヘキサミンなどが挙げられる。代表的なポリアミンとしてはプトレシン、スペルミジン、スペルミンがある。 In the present invention, “polyamine” is a general term for aliphatic hydrocarbons having two or more primary amino groups, and is a natural product that exists universally in the living body, and more than 20 types of polyamines have been found. For example, 1,3-diaminopropane, putrescine, cadaverine, cardine, spermidine, homospermidine, aminopropyl cadaverine, theremin, spermine, thermospermine, canabalmin, aminopentylnorspermidine, N, N-bis (aminopropyl) cadaverine, homo Examples include spermine, cardopentamine, homocardopentamine, cardohexamine, and homocardohexamine. Typical polyamines include putrescine, spermidine and spermine.
本発明で言うところの「プトレシン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を2つもつ脂肪族炭化水素化合物である。「スペルミジン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を3つもつ脂肪族炭化水素化合物である。「スペルミン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を4つもつ脂肪族炭化水素化合物である。
「カダベリン」は代表的なポリアミンの一つで生物体内に普遍的に存在する一般的な天然物であり、第一級アミノ基を2つもつ脂肪族炭化水素化合物である。
In the present invention, “putrescine” is one of typical polyamines and is a general natural product that exists universally in living organisms, and is an aliphatic hydrocarbon compound having two primary amino groups. . “Spermidine” is one of the typical polyamines and is a general natural product ubiquitously present in living organisms, and is an aliphatic hydrocarbon compound having three primary amino groups. “Spermine” is one of the typical polyamines and is a general natural product universally present in living organisms, and is an aliphatic hydrocarbon compound having four primary amino groups.
“Cadaverine” is one of the typical polyamines and is a general natural product that exists universally in living organisms, and is an aliphatic hydrocarbon compound having two primary amino groups.
必要に応じてポリアミン組成物は、イオン交換法、膜分画法、ゲル濾過法、電気透析法で脱塩処理や精製処理を行っても良く、これらの方法を少なくとも1つ以上実施することで、より高純度なポリアミン組成物を得ることができる。例えば、イオン交換法としては、ポリアミン溶液をイオン交換樹脂を充填したカラムに通し、ポリアミンとアミノ酸、ペプチド、蛋白質、糖類等の夾雑物とを分離する。使用するイオン交換樹脂としては、イオン交換基がスルホン酸基、スルホプロピル基、リン酸基、カルボキシルメチル基、アミノエチル基、ジエチルアミノ基、4級アミノエチル基、4級アンモニウム基等であればよく、陽イオン交換樹脂でも陰イオン交換樹脂でもいずれも使用することができる。陽イオン交換樹脂を使用した場合には、ポリアミンは陽イオン交換樹脂に吸着されるので、非吸着物質を十分に分離した後、硫酸、塩酸等の酸性溶液や塩化ナトリウム等の塩溶液でポリアミンを溶出する。陰イオン交換樹脂を使用した場合には、ポリアミンは陰イオン交換樹脂に吸着されないので、ポリアミンを含む非吸着画分を回収する。例えば、膜分画法としては、セルロース系、酢酸セルロース系、ポリスルホン系、ポリアミド系、ポリアクリルニトリル系、ポリ四フッ化エチレン系、ポリエステル系、ポリプロピレン系等で分画分子量が1000〜100000の範囲の限外濾過(UF)膜を使用してポリアミン組成物のUFを行い、ポリアミンを含む透過液を回収する。また、食塩阻止率30〜80%のナノフィルトレーション (NF) 膜を使用してポリアミン溶液のNFを行い、脱塩する。例えば、ゲル濾過法は、ポリアミン組成物を中和し、ゲル濾過担体を充填したカラムに通して分子量分画によりポリアミンを回収する。使用するゲル濾過担体は、デキストラン系、アクリルアミド系、アガロース系、セルロース系、ポリビニル系、ガラス系、ポリスチレン系などで分画分子量が100〜100000の範囲である。例えば、電気透析法は、陽イオン交換膜と陰イオン交換膜とによって仕切られた各膜間にポリアミン組成物と食塩水とを交互に供給して電気透析を行う。 If necessary, the polyamine composition may be subjected to desalting treatment or purification treatment by ion exchange method, membrane fractionation method, gel filtration method, electrodialysis method, and by carrying out at least one of these methods. A higher purity polyamine composition can be obtained. For example, as an ion exchange method, a polyamine solution is passed through a column packed with an ion exchange resin to separate the polyamine from impurities such as amino acids, peptides, proteins, and sugars. As the ion exchange resin to be used, the ion exchange group may be a sulfonic acid group, sulfopropyl group, phosphoric acid group, carboxylmethyl group, aminoethyl group, diethylamino group, quaternary aminoethyl group, quaternary ammonium group, etc. Either a cation exchange resin or an anion exchange resin can be used. When a cation exchange resin is used, the polyamine is adsorbed on the cation exchange resin. Therefore, after sufficiently separating non-adsorbed substances, the polyamine is removed with an acidic solution such as sulfuric acid or hydrochloric acid, or a salt solution such as sodium chloride. Elute. When an anion exchange resin is used, the polyamine is not adsorbed on the anion exchange resin, and thus the non-adsorbed fraction containing the polyamine is collected. For example, as a membrane fractionation method, cellulose, cellulose acetate, polysulfone, polyamide, polyacrylonitrile, polytetrafluoroethylene, polyester, polypropylene and the like have a fractional molecular weight in the range of 1000 to 100,000. The polyamine composition is subjected to UF using an ultrafiltration (UF) membrane, and the permeate containing the polyamine is recovered. Further, NF of the polyamine solution is performed using a nanofiltration (NF) membrane having a salt rejection rate of 30 to 80% for desalting. For example, in the gel filtration method, the polyamine composition is neutralized and passed through a column packed with a gel filtration carrier to recover the polyamine by molecular weight fractionation. The gel filtration carrier used is a dextran-based, acrylamide-based, agarose-based, cellulose-based, polyvinyl-based, glass-based, polystyrene-based, or the like with a molecular weight cut-off in the range of 100 to 100,000. For example, in electrodialysis, electrodialysis is performed by alternately supplying a polyamine composition and saline between each membrane partitioned by a cation exchange membrane and an anion exchange membrane.
本発明の爪におけるセラミド含量増加剤は、各種飲食品の素材として使用することができる。飲食品としては、例えば、食用油(サラダ油、菓子類(ガム、キャンディー、キャラメル、チョコレート、クッキー、スナック、ゼリー、グミ、錠菓等)、麺類(そば、うどん、ラーメン等)、乳製品(ミルク、アイスクリーム、ヨーグルト等)、調味料(味噌、醤油等)、スープ類、飲料(ジュース、コーヒー、紅茶、茶、炭酸飲料、スポーツ飲料等)をはじめとする一般食品や、健康食品(錠剤、カプセル等)、栄養補助食品(栄養ドリンク等)が挙げられる。これらの飲食品に本発明の爪におけるセラミド含量増加剤を適宜配合するとよい。 The ceramide content increasing agent in the nail | claw of this invention can be used as a raw material of various food-drinks. Examples of food and drink include edible oil (salad oil, confectionery (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummi, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), and dairy products (milk , Ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) and health foods (tablets, Capsules, etc.), dietary supplements (nutrient drinks, etc.) These foods and drinks may be appropriately mixed with the ceramide content increasing agent in the nail of the present invention.
これら飲食品には、その種類に応じて種々の成分を配合することができ、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、L−アスコルビン酸、dl−α−トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンB類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤等の食品素材を使用することができる。さらに、健康維持機能をもった本爪におけるセラミド含量増加剤には、他の抗酸化物質や健康食品素材など、例えば、還元型アスコルビン酸(ビタミンC)、ビタミンE、還元型グルタチン、トコトリエノール、ビタミンA誘導体、リコピン、β−クリプトキサンチン、アスタキサンチン、ゼアキサンチン、フコキサンチン、尿酸、ユビキノン、コエンザイムQ10、葉酸、ニンニクエキス、アリシン、セサミン、リグナン類、カテキン、イソフラボン、カルコン、タンニン類、フラボノイド類、クマリン、イソクマリン類、ブルーベリーエキス、健康食品素材)V.(ビタミン)A、V.B1、V.B2、V.B6、V.B12、V.C、V.D、V.E、V.P、コリン、ナイアシン、パントテン酸、葉酸カルシウム、EPA、オリゴ糖、食物繊維、スクアレン、大豆レシチン、タウリン、ドナリエラ、プロテイン、オクタコサノール、DHA、卵黄レシチン、リノール酸、ラクトフェリン、マグネシウム、亜鉛、クロム、セレン、カリウム、ヘム鉄、カキ肉エキス、キトサン、キチンオリゴ糖、コラーゲン、コンドロイチン、エラスチン、ウコン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、シジミエキス、スッポン、カンゾウ、クコシ、ケイヒ、セイヨウ、サンザシ、生姜、霊芝、オオバコ、カミツレ、カモミール、セイヨウタンポポ、ハイビスカス、ハチミツ、ボーレン、ローヤルゼリー、ライム、ラベンダー、ローズヒップ、ローズマリー、セージ、ビフィズス菌、フェーカリス菌、ラクリス、小麦胚芽油、ゴマ油、シソ油、大豆油、中鎖脂肪酸、アガリクス、イチョウ葉エキス、コンドロイチン、玄米胚芽エキス、レイシ、タマネギ、DHA、EPA、DPA、甜茶、冬虫夏草、ニンニク、蜂の子、パパイヤ、プーアル、プロポリス、メグスリの木、ヤブシタケ、ロイヤルゼリー、ノコギリヤシ、ヒアルロン酸、ギャバ、ハープシールオイル、サメ軟骨、グルコサミン、レシチン、ホスファチジルセリン、田七ニンジン、桑葉、大豆抽出物、エキナセア、エゾウコギ、大麦抽出物、オリーブ葉、オリーブ実、ギムネマ、バナバ、サラシア、ガルシニア、キトサン、セントジョーンズワート、ナツメ、ニンジン、パッションフラワー、ブロッコリー、プラセンタ、ハトムギ、ブドウ種子、ピーナッツ種皮、ビルベリー、ブラックコホシュ、マリアアザミ、月桂樹、セージ、ローズマリー、ラフマ、黒酢、ゴーヤー、マカ、紅花、亜麻、ウーロン茶、花棘、カフェイン、カプサイシン、キシロオリゴ糖、グルコサミン、ソバ、シトラス、食物繊維、プロテイン、プルーン、スピルリナ、大麦若葉、核酸、酵母、椎茸、梅肉、アミノ酸、深海鮫抽出物、ノニ、カキ肉、スッポン、シャンピニオン、オオバコ、アセロラ、パイナップル、バナナ、モモ、アンズ、メロン、イチゴ、ラズベリー、オレンジ、フコイダン、メシマコブ、クランベリー、亜鉛、鉄、シルクペプチド、グリシン、ナイアシン、チェストツリー、セラミド、L−システイン、赤ワイン果汁、ミレット、ホーステール、ビオチン、センテラアジアティカ、ハスカップ、ピクノジェノール、フキ、ルバーブ、クローブ、プーアル、クエン酸、ビール酵母、メリロート、ブラックジンガー、ショウガ、ガジュツ、ナットウキナーゼ、ベニコウジ、トコトリエノール、ラクトフェリン、韃靼ソバ、ココア、ドクダミ、キウイ、ヒハツ、ハスの葉、パフィア、スターフルーツなども配合することができる。 These foods and drinks can be blended with various ingredients depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. Furthermore, the ceramide content increasing agent in the nail having a health maintenance function includes other antioxidants and health food materials such as reduced ascorbic acid (vitamin C), vitamin E, reduced glutatin, tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sesamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids, coumarin, Isocoumarins, blueberry extract, health food materials) (Vitamin) A, V. B1, V. B2, V.B. B6, V.I. B12, V.I. C, V.D. D, V.D. E, V.E. P, choline, niacin, pantothenic acid, calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soy lecithin, taurine, donariella, protein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium , Potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, elastin, turmeric, licorice, kokushi, keihi, hawthorn, ginger, ganoderma, swordfish extract, suppon, licorice, kokushi, keihi, seiyou Hawthorn, ginger, ganoderma, plantain, chamomile, chamomile, dandelion, hibiscus, honey, boren, royal jelly, lime, lavender, rosehip, rosemary, sage, bifidobacteria, faecalis Lacris, wheat germ oil, sesame oil, perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA, strawberry tea, cordyceps, garlic, bee, Papaya, Puaru, Propolis, Meguri Tree, Yabushitake, Royal Jelly, Saw Palmetto, Hyaluronic Acid, Gabba, Harpseal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Padlock Carrot, Mulberry Leaf, Soybean Extract, Echinacea, Ekokogi , Barley extract, olive leaf, olive fruit, Gymnema, banaba, Salacia, Garcinia, chitosan, St. John's wort, jujube, carrot, passionflower, broccoli, placenta, pearl barley, grape seed, peanut seed coat, bilberry, buoy Cook Cohosh, Maria Thistle, Laurel, Sage, Rosemary, Luffa, Black Vinegar, Goya, Maca, Safflower, Flax, Oolong Tea, Flower Thorn, Caffeine, Capsaicin, Xylooligosaccharide, Glucosamine, Buckwheat, Citrus, Dietary Fiber, Protein, Prunes , Spirulina, Barley Young Leaves, Nucleic Acid, Yeast, Shiitake Mushroom, Plum Meat, Amino Acid, Deep Sea Mushroom Extract, Noni, Oyster Meat, Suppon, Champignon, Plantain, Acerola, Pineapple, Banana, Peach, Apricot, Melon, Strawberry, Raspberry, Orange , Fucoidan, Meshima Cobb, Cranberry, Zinc, Iron, Silk Peptide, Glycine, Niacin, Chest Tree, Ceramide, L-Cysteine, Red Wine Juice, Millet, Horsetail, Biotin, Centella Asiatica, Hascup, Pycnogenol, Fuqui, Ruba Bulb, clove, puer, citric acid, brewer's yeast, merirot, black zinger, ginger, gadget, nattokinase, benichouji, tocotrienol, lactoferrin, buckwheat, cocoa, dokudami, kiwi, hihatu, lotus leaf, paffia, star fruit, etc. Can be blended.
具体的な製法としては、爪におけるセラミド含量増加剤を粉末セルロースとともにスプレードライまたは凍結乾燥し、これを粉末、顆粒、打錠または溶液にすることで容易に飲食品(インスタント食品等)に含有させることができる。
爪におけるセラミド含量増加剤を、例えば、油脂、エタノール、グリセリンあるいはこれらの混合物に溶解して液状にし、飲料に添加するか、固形食品に添加することが可能である。必要に応じてアラビアガム、デキストリン等のバインダーと混合して粉末状あるいは顆粒状にし、飲料に添加するか固形食品に添加することも可能である。
As a specific manufacturing method, a ceramide content increasing agent in nails is spray-dried or freeze-dried together with powdered cellulose, and this is easily made into powders, granules, tablets, or solutions to be easily contained in foods and drinks (instant foods, etc.) be able to.
The ceramide content increasing agent in the nail can be dissolved in, for example, fats and oils, ethanol, glycerin, or a mixture thereof to form a liquid and added to a beverage or added to a solid food. If necessary, it can be mixed with a binder such as gum arabic or dextrin to form a powder or granules and added to a beverage or a solid food.
本発明の爪におけるセラミド含量増加剤を飲食品に適用する場合の添加量としては、病気予防や健康維持が主な目的であるので、飲食品に対して有効成分の含量が合計1〜20wt%以下であるのが好ましい。 As the addition amount when applying the ceramide content increasing agent in the nail of the present invention to foods and drinks, the main purpose is disease prevention and health maintenance, so the total content of active ingredients is 1 to 20 wt% with respect to foods and drinks. It is preferable that:
本発明の爪におけるセラミド含量増加剤は、薬品(医薬品および医薬部外品を含む。)の素材として用いてもよい。薬品製剤用の原料に、本発明の爪におけるセラミド含量増加剤を適宜配合して製造することができる。本発明爪におけるセラミド含量増加剤に配合しうる製剤原料としては、例えば、賦形剤(ブドウ糖、乳糖、白糖、塩化ナトリウム、デンプン、炭酸カルシウム、カオリン、結晶セルロース、カカオ脂、硬化植物油、カオリン、タルク等)、結合剤(蒸留水、生理食塩水、エタノール水、単シロップ、ブドウ糖液、デンプン液、ゼラチン溶液、カルボキシメチルセルロース、リン酸カリウム、ポリビニルピロリドン等)、崩壊剤(アルギン酸ナトリウム、カンテン、炭酸水素ナトリウム、炭酸カルシウム、ラウリル硫酸ナトリウム、ステアリン酸モノグリセリド、デンプン、乳糖、アラビアゴム末、ゼラチン、エタノール等)、崩壊抑制剤(白糖、ステアリン、カカオ脂、水素添加油等)、吸収促進剤(第四級アンモニウム塩基、ラウリル硫酸ナトリウム等)、吸着剤(グリセリン、デンプン、乳糖、カオリン、ベントナイト、硅酸等)、滑沢剤(精製タルク、ステアリン酸塩、ポリエチレングリコール等)などが挙げられる。 The ceramide content increasing agent in the nail of the present invention may be used as a raw material for drugs (including pharmaceuticals and quasi drugs). The ceramide content increasing agent in the nail | claw of this invention can be suitably mix | blended with the raw material for chemical | medical agents preparation, and can be manufactured. Examples of the preparation raw material that can be blended in the ceramide content increasing agent in the nail of the present invention include, for example, excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hydrogenated vegetable oil, kaolin, Talc, etc.), binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, agar, carbonate) Sodium hydride, calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitors (sucrose, stearin, cocoa butter, hydrogenated oil, etc.), absorption enhancers (No. Quaternary ammonium base, lauryl sulfate Thorium, etc.), adsorbents (glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearates, polyethylene glycol, and the like) and the like.
本発明に爪におけるセラミド含量増加剤の投与方法は、一般的には、錠剤、丸剤、軟・硬カプセル剤、細粒剤、散剤、顆粒剤、液剤等の形態で経口投与することができるが、非経口投与であってもよい。非経口剤として投与する場合は、溶液の状態、または分散剤、懸濁剤、安定剤などを添加した状態で、ハップ剤、ローション剤、軟膏剤、チンキ剤、クリーム剤などの剤形で適用することができる。 In the present invention, the administration method of the ceramide content increasing agent in the nail can generally be administered orally in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules, liquids, etc. However, parenteral administration may also be used. When administered as a parenteral agent, it can be applied in the form of a solution, or added with a dispersant, suspension, stabilizer, etc. can do.
爪におけるセラミド含量増加剤の配合比は、剤型によって適宜変更することが可能であるが、通常、経口または粘膜吸収により投与される場合は約0.3〜15.0wt%、非経口投与による場合は、0.01〜10wt%程度にするとよい。なお、投与量は種々の条件で異なるので、前記投与量より少ない量で十分な場合もあるし、また、範囲を超えて投与する必要のある場合もある。 The compounding ratio of the ceramide content increasing agent in the nail can be appropriately changed depending on the dosage form, but is usually about 0.3 to 15.0 wt% when administered orally or by mucosal absorption, depending on parenteral administration In such a case, the content may be about 0.01 to 10 wt%. In addition, since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range.
本発明の爪におけるセラミド含量増加剤は、皮膚外用剤(化粧品、医薬品および医薬部外品を含む。)として用いても、爪におけるセラミド含量増加作用を期待することができる。尚、上記皮膚外用剤は人間に用いても良いし、人間以外の哺乳類動物に用いても良い。
本発明の爪におけるセラミド含量増加剤を配合しうる皮膚外用剤の形態としては、例えば、乳液、石鹸、洗顔料、入浴剤、クリーム、乳液、化粧水、オーデコロン、ひげ剃り用クリーム、ひげ剃り用ローション、化粧油、日焼け・日焼け止めローション、おしろいパウダー、ファンデーション、香水、パック、爪クリーム、エナメル、エナメル除去液、眉墨、ほお紅、アイクリーム、アイシャドー、マスカラ、アイライナー、口紅、リップクリーム、シャンプー、リンス、染毛料、分散液、洗浄料等が挙げられる。
また、本発明爪におけるセラミド含量増加剤を配合しうる医薬品または医薬部外品の形態としては、軟膏剤、クリーム剤、外用液剤等が挙げられる。
Even if the ceramide content increasing agent in the nail | claw of this invention is used as a skin external preparation (a cosmetics, a pharmaceutical, and a quasi-drug are included), the ceramide content increasing effect in a nail | claw can be anticipated. In addition, the said skin external preparation may be used for a human and may be used for mammals other than a human.
Examples of the external preparation for skin to which the ceramide content increasing agent in the nail of the present invention can be formulated include, for example, emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shave cream, and shave Lotion, cosmetic oil, tan / sunscreen lotion, powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo , Rinse, hair dye, dispersion, cleaning agent and the like.
Examples of the form of a pharmaceutical or quasi-drug that can contain the ceramide content increasing agent in the nail of the present invention include ointments, creams, and liquids for external use.
上記形態の皮膚外用剤には、本発明による爪におけるセラミド含量増加剤の他に、その爪におけるセラミド含量増加作用を損なわない範囲で化粧品、医薬部外品などの皮膚外用剤に配合される成分、油分、高級アルコール、脂肪酸、紫外線吸収剤、粉体、顔料、界面活性剤、多価アルコール・糖、高分子、生理活性成分、溶媒、酸化防止剤、香料、防腐剤等を配合することができる。
例を以下に羅列するが、本発明はこれらの例に限定されるものではない。
In addition to the ceramide content-increasing agent in the nail according to the present invention, the external preparation for skin of the above form is a component blended in a skin external preparation such as cosmetics and quasi-drugs as long as the ceramide content increasing effect in the nail is not impaired , Oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. it can.
Examples are listed below, but the present invention is not limited to these examples.
(1)油分の例
エステル系の油相成分:トリ2-エチルヘキサン酸グリセリル、2-エチルヘキサン酸セチル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、パルミチン酸オクチル、イソステアリン酸イソセチル、ステアリン酸ブチル、ミリスチン酸ブチル、リノール酸エチル、リノール酸イソプロピル、オレイン酸エチル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソステアリル、ミリスチン酸オクチルドデシル、イソステアリン酸イソセチル、セバシン酸ジエチル、アジピン酸ジイソプロピル、ネオペンタン酸イソアラキル、トリ(カプリル・カプリン酸)グリセリル、トリ2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2-エチルヘキサン酸ペンタエリスリトール、カプリル酸セチル、ラウリン酸デシル、ラウリン酸ヘキシル、ミリスチン酸デシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、リシノレイン酸セチル、ラウリン酸イソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸オクチル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、リノール酸オクチルドデシル、イソステアリン酸イソプロピル、2-エチルヘキサン酸セトステアリル、2-エチルヘキサン酸ステアリル、イソステアリン酸ヘキシル、ジオクタン酸エチレングリコール、ジオレイン酸エチレングリコール、ジカプリン酸プロピレングリコール、ジ(カプリル・カプリン酸)プロピレングリコール、ジカプリル酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸ネオペンチルグリコール、トリカプリル酸グリセリル、トリウンデシル酸グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸グリセリル、ネオペンタン酸オクチルドデシル、オクタン酸イソステアリル、イソノナン酸オクチル、ネオデカン酸ヘキシルデシル、ネオデカン酸オクチルドデシル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸オクチルデシル、ポリグリセリンオレイン酸エステル、ポリグリセリンイソステアリン酸エステル、炭酸ジプロピル、炭酸ジアルキル(C12-18)、クエン酸トリイソセチル、クエン酸トリイソアラキル、クエン酸トリイソオクチル、乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸オクチルデシル、クエン酸トリエチル、クエン酸アセチルトリエチル、クエン酸アセチルトリブチル、クエン酸トリオクチル、リンゴ酸ジイソステアリル、ヒドロキシステアリン酸2-エチルヘキシル、コハク酸ジ2-エチルヘキシル、アジピン酸ジイソブチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、ステアリン酸コレステリル、イソステアリン酸コレステリル、ヒドロキシステアリン酸コレステリル、オレイン酸コレステリル、オレイン酸ジヒドロコレステリル、イソステアリン酸フィトステリル、オレイン酸フィトステリル、12-ステアロイルヒドロキシステアリン酸イソセチル、12-ステアロイルヒドロキシステアリン酸ステアリル、12-ステアロイルヒドロキシステアリン酸イソステアリル等が挙げられる。
炭化水素系の油相成分:スクワラン、流動パラフィン、α-オレフィンオリゴマー、イソパラフィン、セレシン、パラフィン、流動イソパラフィン、ポリブテン、マイクロクリスタリンワックス、ワセリン等が挙げられる。
動植物油とその硬化油、および天然由来のロウ:牛脂、硬化牛脂、豚脂、硬化豚脂、馬油、硬化馬油、ミンク油、オレンジラフィー油、魚油、硬化魚油、卵黄油等の動物油およびその硬化油、アボカド油、アルモンド油、オリーブ油、カカオ脂、キウイ種子油、杏仁油、ククイナッツ油、ゴマ油、小麦胚芽油、コメ胚芽油、コメヌカ油、サフラワー油、シアバター、大豆油、月見草油、シソ油、茶実油、ツバキ油、トウモロコシ油、ナタネ油、硬化ナタネ油、パーム核油、硬化パーム核油、パーム油、硬化パーム油、ピーナッツ油、硬化ピーナッツ油、ヒマシ油、硬化ヒマシ油、ヒマワリ油、ブドウ種子油、ホホバ油、硬化ホホバ油、マカデミアナッツ油、メドホーム油、綿実油、硬化綿実油、ヤシ油、硬化ヤシ油等の植物油およびその硬化油、ミツロウ、高酸価ミツロウ、ラノリン、還元ラノリン、硬化ラノリン、液状ラノリン、カルナバロウ、モンタンロウ等のロウ等が挙げられる。
シリコーン系の油相成分:ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルシクロポリシロキサン、オクタメチルポリシロキサン、デカメチルポリシロキサン、ドデカメチルシクロシロキサン、メチルハイドロジェンポリシロキサン、ポリエーテル変性オルガノポリシロキサン、ジメチルシロキサン・メチルセチルオキシシロキサン共重合体、ジメチルシロキサン・メチルステアロキシシロキサン共重合体、アルキル変性オルガノポリシロキサン、末端変性オルガノポリシロキサン、アミノ変性シリコーン油、アミノ変性オルガノポリシロキサン、ジメチコノール、シリコーンゲル、アクリルシリコーン、トリメチルシロキシケイ酸、シリコーンRTVゴム等が挙げられる。
フッ素系の油相成分:パーフルオロポリエーテル、フッ素変性オルガノポリシロキサン、フッ化ピッチ、フルオロカーボン、フルオロアルコール、フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン等が挙げられる。
(1) Examples of oil components Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaralkyl neopentanoate, glyceryl tri (capryl / caprate), trimethylolpropane tri-2-ethylhexanoate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl linoleate, octyldodecyl isoleate, isopropyl isostearate Cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethyleneglycol dioctanoate , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisopalmitine Glyceryl acid, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyl decyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleic acid Ester, polyglycerol isostearate, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, olein Cholesteryl acid, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil and other animal oils and Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil , Vegetable oils such as sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened , Beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.
(2)高級アルコールの例
ラウリルアルコール、ミリスチルアルコール、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、ベヘニルアルコール、2-エチルヘキサノール、ヘキサデシルアルコール、オクチルドデカノール等が挙げられる。
(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.
(3)脂肪酸の例
カプリル酸、カプリン酸、ウンデシレン酸、ラウリン酸、ミリスチン酸、パルミチン酸、パルミトレイン酸、ステアリン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸、アラキン酸、アラキドン酸、ベヘン酸、エルカ酸、2-エチルヘキサン酸等が挙げられる。
(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.
(4)紫外線吸収剤の例
パラアミノ安息香酸、パラアミノ安息香酸アミル、パラアミノ安息香酸エチルジヒドロキシプロピル、パラアミノ安息香酸グリセリル、パラアミノ安息香酸エチル、パラアミノ安息香酸オクチル、パラアミノ安息香酸オクチルジメチル、サリチル酸エチレングリコール、サリチル酸オクチル、サリチル酸トリエタノールアミン、サリチル酸フェニル、サリチル酸ブチルフェニル、サリチル酸ベンジル、サリチル酸ホモメンチル、ケイ皮酸ベンジル、パラメトキシケイ皮酸オクチル、パラメトキシケイ皮酸2-エチルヘキシル、ジパラメトキシケイ皮酸モノ2-エチルヘキサン酸グリセリル、パラメトキシケイ皮酸イソプロピル、パラメトキシヒドロケイ皮酸ジエタノールアミン塩、ジイソプロピル・ジイソプロピルケイ皮酸エステル混合物、ウロカニン酸、ウロカニン酸エチル、ヒドロキシメトキシベンゾフェノン、ヒドロキシメトキシベンゾフェノンスルホン酸及びその塩、ジヒドロキシメトキシベンゾフェノン、ジヒドロキシメトキシベンゾフェノンジスルホン酸ナトリウム、ジヒドロキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン、ヒドロキシオクトキシベンゾフェノン、テトラヒドロキシベンゾフェノン、ブチルメトキシジベンゾイルメタン、2、4、6-トリアニリノ-p-(カルボ-2-エチルヘキシル-1-オキシ)-1、3、5-トリアジン、2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール、メチル-O-アミノベンゾエート、2-エチルヘキシル-2-シアノ-3、3-ジフェニルアクリレート、フェニルベンゾイミダゾール硫酸、3-(4-メチルベンジリデン)カンフル、イソプロピルジベンゾイルメタン、4-(3、4-ジメトキシフェニルメチレン)-2、5-ジオキソ-1-イミダゾリジンプロピオン酸2-エチルヘキシル等、およびこれらの高分子誘導体やシラン誘導体等が挙げられる。
(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Examples include full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, and the like, polymer derivatives, silane derivatives, and the like.
(5)粉体・顔料の例
赤色104号、赤色201号、黄色4号、青色1号、黒色401号等の色素、黄色4号ALレーキ、黄色203号BAレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、ウレタンパウダー、テフロン(登録商標)パウダー、シリコーンパウダー、ポリメタクリル酸メチルパウダー、セルロースパウダー、デンプン、シリコーンエラストマー球状粉体、ポリエチレン末等の高分子、黄酸化鉄、赤色酸化鉄、黒酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン、酸化セリウム等の白色顔料、タルク、マイカ、セリサイト、カオリン、板状硫酸バリウム等の体質顔料、雲母チタン等のパール顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸アルミニウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ステアリン酸アルミニウム、ステアリン酸マグネシウム、パルミチン酸亜鉛、ミリスチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛等の金属セッケン、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状(球状、棒状、針状、板状、不定形状、燐片状、紡錘状等)および粒子径に特に制限はない。なおこれらの粉体は、従来公知の表面処理、例えばフッ素化合物処理、シリコーン処理、シリコーン樹脂処理、ペンダント処理、シランカップリング剤処理、チタンカップリング剤処理、油剤処理、N-アシル化リジン処理、ポリアクリル酸処理、金属セッケン処理、アミノ酸処理、レシチン処理、無機化合物処理、プラズマ処理、メカノケミカル処理等によって事前に表面処理されていてもいなくても構わない。
(5) Examples of powders and pigments Red 104, Red 201, Yellow 4,
(6)界面活性剤の例
アニオン性界面活性剤:脂肪酸セッケン、α-アシルスルホン酸塩、アルキルスルホン酸塩、アルキルアリルスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキル硫酸塩、POEアルキルエーテル硫酸塩、アルキルアミド硫酸塩、アルキルリン酸塩、POEアルキルリン酸塩、アルキルアミドリン酸塩、アルキロイルアルキルタウリン塩、N-アシルアミノ酸塩、POEアルキルエーテルカルボン酸塩、アルキルスルホコハク酸塩、アルキルスルホ酢酸ナトリウム、アシル化加水分解コラーゲンペプチド塩、パーフルオロアルキルリン酸エステル等が挙げられる。
カチオン性界面活性剤:塩化アルキルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、塩化セトステアリルトリメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、臭化ベヘニルトリメチルアンモニウム、塩化ベンザルコニウム、塩化ベヘニン酸アミドプロピルジメチルヒドロキシプロピルアンモニウム、ステアリン酸ジエチルアミノエチルアミド、ステアリン酸ジメチルアミノプロピルアミド、ラノリン誘導体第四級アンモニウム塩等が挙げられる。
両性界面活性剤:カルボキシベタイン型、アミドベタイン型、スルホベタイン型、ヒドロキシスルホベタイン型、アミドスルホベタイン型、ホスホベタイン型、アミノカルボン酸塩型、イミダゾリン誘導体型、アミドアミン型等が挙げられる。
ノニオン性界面活性剤:プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、POEソルビタン脂肪酸エステル、POEソルビット脂肪酸エステル、POEグリセリン脂肪酸エステル、POEアルキルエーテル、POE脂肪酸エステル、POE硬化ヒマシ油、POEヒマシ油、POE・POP共重合体、POE・POPアルキルエーテル、ポリエーテル変性シリコーンラウリン酸アルカノールアミド、アルキルアミンオキシド、水素添加大豆リン脂質等が挙げられる。
天然系界面活性剤:レシチン、サポニン、糖系界面活性剤等が挙げられる。
(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, etc. are mentioned.
Cationic surfactant: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant: lecithin, saponin, sugar surfactant and the like.
(7)多価アルコール、糖の例
エチレングリコール、ジエチレングリコール、ポリエチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン、ジグリセリン、ポリグリセリン、3-メチル-1、3-ブタンジオール、1、3-ブチレングリコール、ソルビトール、マンニトール、ラフィノース、エリスリトール、グルコース、ショ糖、果糖、キシリトール、ラクトース、マルトース、マルチトール、トレハロース、アルキル化トレハロース、混合異性化糖、硫酸化トレハロース、プルラン等が挙げられる。またこれらの化学修飾体等も使用可能である。
(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.
(8)高分子の例
アクリル酸エステル/メタクリル酸エステル共重合体(プラスサイズ、互応化学社製)、酢酸ビニル/クロトン酸共重合体(レジン28-1310、NSC社製)、酢酸ビニル/クロトン酸/ビニルネオデカネート共重合体(28-2930、NSC社製)、メチルビニルエーテルマレイン酸ハーフエステル(ガントレッツES、ISP社製)、T-ブチルアクリレート/アクリル酸エチル/メタクリル酸共重合体(ルビマー、BASF社製)、ビニルピロリドン/ビニルアセテート/ビニルプロピオネート共重合体(ルビスコールVAP、BASF社製)、ビニルアセテート/クロトン酸共重合体(ルビセットCA、BASF社製)、ビニルアセテート/クロトン酸/ビニルピロリドン共重合体(ルビセットCAP、BASF社製)、ビニルピロリドン/アクリレート共重合体(ルビフレックス、BASF社製)、アクリレート/アクリルアミド共重合体(ウルトラホールド、BASF社製)、ビニルアセテート/ブチルマレエート/イソボルニルアクリラート共重合体(アドバンテージ、ISP社製)、カルボキシビニルポリマー(カーボポール、BFGoodrich社製)、アクリル酸・メタクリル酸アルキル共重合体(ペミュレン、BF Goodrich社製)等のアニオン性高分子化合物や、ジアルキルアミノエチルメタクリレート重合体の酢酸両性化物(ユカフォーマー、三菱化学社製)、アクリル酸オクチルアクリルアミド/アクリル酸ヒドロキシプロピル/メタクリル酸ブチルアミノエチル共重合体(AMPHOMER、NSC社製)等の両性高分子化合物、ビニルピロリドン/ジメチルアミノエチルメタクリレートの4級化物(GAFQUAT、ISP社製)、メチルビニルイミダゾリウムクロリド/ビニルピロリドン共重合体(ルビコート、BASF社製)等のカチオン性高分子化合物、ポリビニルピロリドン(ルビスコールK、BASF社製)、ビニルピロリドン/酢酸ビニル共重合体(ルビスコールVA、BASF社製)、ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマー937、ISP社製)、ビニルカプロラクタム/ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマーVC713、ISP社製)等のノニオン性高分子化合物等がある。また、セルロースまたはその誘導体、ケラチン及びコラーゲンまたはその誘導体、アルギン酸カルシウム、プルラン、寒天、ゼラチン、タマリンド種子多糖類、キサンタンガム、カラギーナン、ハイメトキシルペクチン、ローメトキシルペクチン、グアーガム、アラビアゴム、結晶セルロース、アラビノガラクタン、カラヤガム、トラガカントガム、アルギン酸、アルブミン、カゼイン、カードラン、ジェランガム、デキストラン等の天然由来高分子化合物も好適に用いることができる。
(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxy vinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as vinyl / vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) ), Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. There is. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.
(9)生理活性成分の例
生理活性成分としては、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば、美白成分、免疫賦活剤、老化防止剤、紫外線防御剤、スリミング剤、ひきしめ剤、抗酸化剤、発毛剤、育毛剤、保湿剤、血行促進剤、抗菌剤、殺菌剤、乾燥剤、冷感剤、温感剤、ビタミン類、アミノ酸、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、酵素成分等が挙げられる。これらの好適な配合成分の例としては、例えばアシタバエキス、アボカドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エイジツエキス、エチナシ葉エキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オトギリソウエキス、オドリコソウエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、加水分解エラスチン、加水分解小麦末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、甘草エキス、カルカデエキス、カキョクエキス、キナエキス、キューカンバ-エキス、グアノシン、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、クロレラエキス、クワエキス、ゲンチアナエキス、紅茶エキス、酵母エキス、ゴボウエキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、シャクヤクエキス、ショウブ根エキス、シラカバエキス、スギナエキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セ-ジエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ダイズエキス、タイソウエキス、タイムエキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、リンゴエキス、レタスエキス、レモンエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス等を挙げることができる。
また、デオキシリボ核酸、ムコ多糖類、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、キチン、キトサン、加水分解卵殻膜などの生体高分子、アミノ酸、加水分解ペプチド、乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム、ベタイン、ホエイ、トリメチルグリシンなどの保湿成分、スフィンゴ脂質、セラミド、フィトスフィンゴシン、コレステロール、コレステロール誘導体、リン脂質などの油性成分、ε-アミノカプロン酸、グリチルリチン酸、β-グリチルレチン酸、塩化リゾチーム、グアイアズレン、ヒドロコールチゾン等の免疫賦活剤、ビタミンA、ビタミンB2、ビタミンB6、ビタミンC、ビタミンD、ビタミンE、パントテン酸カルシウム、ビオチン、ニコチン酸アミド、ビタミンCエステル等のビタミン類、アラントイン、ジイソプロピルアミンジクロロアセテート、4-アミノメチルシクロヘキサンカルボン酸等の活性成分、トコフェロール、カロチノイド、フラボノイド、タンニン、リグナン、サポニン等の抗酸化剤、α-ヒドロキシ酸、β-ヒドロキシ酸などの細胞賦活剤、γ-オリザノール、ビタミンE誘導体などの血行促進剤、レチノール、レチノール誘導体等の創傷治癒剤、アルブチン、コウジ酸、プラセンタエキス、イオウ、エラグ酸、リノール酸、トラネキサム酸、グルタチオン等の美白剤、セファランチン、カンゾウ抽出物、トウガラシチンキ、ヒノキチオール、ヨウ化ニンニクエキス、塩酸ピリドキシン、DL-α-トコフェロール、酢酸DL-α-トコフェロール、ニコチン酸、ニコチン酸誘導体、パントテン酸カルシウム、D-パントテニルアルコール、アセチルパントテニルエチルエーテル、ビオチン、アラントイン、イソプロピルメチルフェノール、エストラジオール、エチニルエストラジオール、塩化カプロニウム、塩化ベンザルコニウム、塩酸ジフェンヒドラミン、タカナール、カンフル、サリチル酸、ノニル酸バニリルアミド、ノナン酸バニリルアミド、ピロクトンオラミン、ペンタデカン酸グリセリル、L-メントール、モノニトログアヤコール、レゾルシン、γ-アミノ酪酸、塩化ベンゼトニウム、塩酸メキシレチン、オーキシン、女性ホルモン、カンタリスチンキ、シクロスポリン、ジンクピリチオン、ヒドロコールチゾン、ミノキシジル、モノステアリン酸ポリオキシエチレンソルビタン、ハッカ油、ササニシキエキス等の育毛剤などが挙げられる。
(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Auren extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat flour, Hydrolyzed silk , Chamomile extract, carrot extract, cormorant extract, licorice extract, calcade extract, cypress extract, kina extract, cucumber extract, guanosine, gardenia extract, kumazasa extract, clara ex , Walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, saicin extract, psycho extract Extract Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senkyu Wu extract, assembly extract, soybean extract, taisu extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, toki extract, tokisenka extract, toninin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bacmond extract, parsley extract, honey, hamamelis extract, parietalia extract, toad extract, bisabolol, loquat extract, dandelion extract, burdock extract, bukuro extract, butcher bloom extract, grape extract, propolis, loofah extract, Safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, pine extract, marronnier extract, mizubashoue , Crocus extract, melissa extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, cypressin extract, mugwort extract, lavender extract, apple extract, lettuce extract, lemon extract, lotus extract, rose extract, rosemary extract, roman chamomile extract And royal jelly extract.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Immunostimulants such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester Vitamins, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-hydroxy acid, β-hydroxy acid, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, etc. Whitening agent, cephalanthin, licorice extract, red pepper tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pan Tothenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyroctone Olamine, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantalis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, monostearic acid Examples include hair growth agents such as polyoxyethylene sorbitan, mint oil, and Sasanishiki extract.
(10)酸化防止剤の例
亜硫酸水素ナトリウム、亜硫酸ナトリウム、エリソルビン酸、エリソルビン酸ナトリウム、チオジプロピオン酸ジラウリル、トコフェロール、トリルビグアナイド、ノルジヒドログアヤレチン酸、パラヒドロキシアニソール、ブチルヒドロキシアニソール、ジブチルヒドロキシトルエン、ステアリン酸アスコルビル、パルミチン酸アスコルビル、没食子酸オクチル、没食子酸プロピル、カロチノイド、フラボノイド、タンニン、ローズマリーエキス、リグナン、サポニン、リンゴエキスやチョウジエキスなどの酸化防止効果の認められる植物エキス等が挙げられる。
(10) Examples of antioxidants Sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolyl biguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts that have an antioxidant effect, such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, rosemary extract, lignan, saponin, apple extract and clove extract It is done.
実施例
米胚芽由来のポリアミン組成物の製造
脱脂米胚芽(120kg)を含水エタノール(45wt%)で抽出して脱脂米胚芽抽出物を得、その脱脂米胚芽抽出物に4倍量の水を添加し、更にクエン酸を添加してpHを酸性に調整して、室温にて抽出した。その後、遠心分離や濾過分離によって液体画分を残査や沈殿と分離し、回収された液体画分を「ポリアミン組成物」として得た(約50kg)。なお、本実施例のポリアミン組成物はポリアミンとして0.33%含有していた。
Example Production of polyamine composition derived from rice germ Extracted defatted rice germ (120 kg) with water-containing ethanol (45 wt%) to obtain a defatted rice germ extract, and added 4 times the amount of water to the defatted rice germ extract Further, citric acid was added to adjust the pH to acidic, and the mixture was extracted at room temperature. Thereafter, the liquid fraction was separated from the residue and precipitate by centrifugation or filtration separation, and the recovered liquid fraction was obtained as a “polyamine composition” (about 50 kg). The polyamine composition of this example contained 0.33% as a polyamine.
試験例1:爪におけるセラミド含量の評価
ポリアミン組成物50 mg配合群とプラセボ群(計20 名,各群10名)のハードカプセルを1日1カプセル2ヶ月間経口摂取してもらい。後述する方法により試験前及び2ヵ月経過したときの爪におけるセラミド含量を測定した。その結果を図1(セラミド5)及び図2(トータルセラミド含量)に示す。
Test Example 1: Evaluation of ceramide content in nail Oral ingestion of hard capsules of 50 mg polyamine composition group and placebo group (20 people, 10 people in each group) per day for 2 months. The ceramide content in the nail was measured by the method described later before the test and after 2 months. The results are shown in FIG. 1 (ceramide 5) and FIG. 2 (total ceramide content).
爪におけるセラミド含量の測定は次に示す方法に基づいて行った。
爪を粉砕しクロロホルム:メタノール=2:1の溶媒で抽出(ジルコニアビーズを使用)した後,遠心分離を行い、その後抽出したセラミドをHPTLCで展開した。(展開溶媒:クロロホルム:メタノール:酢酸=190:9:1)その後10 % CuSO4/8 % H3PO4溶液で処理し,180℃10分加熱しデンシトメトリーでセラミド含量を測定した。
The measurement of the ceramide content in the nail was performed based on the following method.
The nail was pulverized and extracted with a solvent of chloroform: methanol = 2: 1 (using zirconia beads), then centrifuged, and then the extracted ceramide was developed with HPTLC. (Developing solvent: chloroform: methanol: acetic acid = 190: 9: 1) After that, it was treated with a 10% CuSO 4 /8% H 3 PO 4 solution, heated at 180 ° C. for 10 minutes, and the ceramide content was measured by densitometry.
結果及び試験例1における実施例の効果
図1に示されるように、セラミド5またはトータルセラミドについては平均の含量がプラセボ群で減少していたにも関わらず,ポリアミン組成物摂取群でおいては爪のセラミドに平均の含量は増加した。これにより、本実施例のポリアミン組成物はセラミドの含量を増加させる作用を有することが確認された。
Results and Effects of Examples in Test Example 1 As shown in FIG. 1, the average content of ceramide 5 or total ceramide was decreased in the placebo group, but in the polyamine composition intake group, The average content of nail ceramide increased. Thereby, it was confirmed that the polyamine composition of a present Example has the effect | action which increases the content of ceramide.
試験例2:爪の水分蒸散量の評価
ポリアミン組成物50 mg配合群とプラセボ群(計20 名,各群10名)のハードカプセルを1日1カプセル2ヶ月間経口摂取してもらい。試験前及び2ヶ月経過したときにおける爪の水分蒸散の測定をDelfin社製:Vapomaterにより測定した。その結果を図3に示す
Test Example 2: Evaluation of nail moisture transpiration The hard capsules of the
結果及び試験例2における実施例の効果
図3に示すうに、ポリアミン摂取前の爪の水分蒸散量を0 %とした場合、プラセボ群は1ヶ月で28 % 、2ヶ月で53 % 上昇していたのに対して、オリザポリアミン摂取群は1ヶ月で14 % 2ヶ月で25 % 低下していた。これにより、ポリアミンを経口摂取することで爪の水分蒸散を防止することができることか確認された。更に、水分蒸散を防止する理由としてセラミド含量が増加することによるものであることが確認された。
Results and Effects of Examples in Test Example 2 As shown in FIG. 3, the placebo group increased by 28% in 1 month and 53% in 2 months when the moisture transpiration of the nail before polyamine intake was 0%. On the other hand, in the Orizapolyamine intake group, it decreased by 14% in 1 month and 25% in 2 months. Thereby, it was confirmed that the water | moisture content of a nail | claw can be prevented by ingesting a polyamine orally. Furthermore, it was confirmed that the reason for preventing moisture transpiration was that the ceramide content increased.
配合例
以下に本実施例の爪におけるセラミド含量増加剤の配合例を挙げるが、下記配合例は本発明を限定するものではない。
配合例1:チューインガム
砂糖 53.0wt%
ガムベース 20.0
グルコース 10.0
水飴 16.0
香料 0.5
爪におけるセラミド含量増加剤 0.5
100.0wt%
Formulation Example A formulation example of the ceramide content increasing agent in the nail of the present example is given below, but the following formulation example does not limit the present invention.
Formulation Example 1: Chewing gum Sugar 53.0 wt%
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Ceramide content increasing agent in nails 0.5
100.0wt%
配合例2:グミ
還元水飴 40.0wt%
グラニュー糖 20.0
ブドウ糖 20.0
ゼラチン 4.7
水 9.68
イチゴ果汁 4.0
ブドウフレーバー 0.6
色素 0.02
爪におけるセラミド含量増加剤 1.0
100.0wt%
Formulation Example 2: Gummy
Reduced water tank 40.0wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Strawberry juice 4.0
Grape flavor 0.6
Dye 0.02
Ceramide content increasing agent in nails 1.0
100.0wt%
配合例3:キャンディー
砂糖 50.0wt%
水飴 33.0
水 14.4
有機酸 2.0
香料 0.2
爪におけるセラミド含量増加剤 0.4
100.0wt%
Formulation Example 3: Candy
50.0 wt% sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Ceramide content increasing agent in nails 0.4
100.0wt%
配合例4:ヨーグルト(ハード・ソフト)
牛乳 41.5wt%
脱脂粉乳 5.8
砂糖 8.0
寒天 0.15
ゼラチン 0.1
乳酸菌 0.005
爪におけるセラミド含量増加剤 0.4
香料 微量
水 残余
100.0wt%
Formulation Example 4: Yogurt (hard / soft)
Milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Ceramide content increasing agent in nails 0.4
Perfume
Water residue
100.0wt%
配合例5:清涼飲料
果糖ブドウ糖液糖 30.0wt%
乳化剤 0.5
爪におけるセラミド含量増加剤 0.05
香料 適量
精製水 残余
100.0wt%
Formulation Example 5: Soft drink
Fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Ceramide content increasing agent in nails 0.05
Perfume
Purified water residue
100.0wt%
配合例6:錠菓
砂糖 76.4wt%
グルコース 19.0
ショ糖脂肪酸エステル 0.2
爪におけるセラミド含量増加剤 0.5
精製水 3.9
100.0wt%
Formulation Example 6: Tablets
76.4 wt% sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Ceramide content increasing agent in nails 0.5
Purified water 3.9
100.0wt%
配合例7:ソフトカプセル
イチゴ種子油 87.0wt%
乳化剤 12.0
爪におけるセラミド含量増加剤 1.0
100.0wt%
Formulation Example 7: Soft capsule
Strawberry seed oil 87.0wt%
Emulsifier 12.0
Ceramide content increasing agent in nails 1.0
100.0wt%
配合例8:錠剤
乳糖 54.0wt%
結晶セルロース 30.0
澱粉分解物 10.0
グリセリン脂肪酸エステル 5.0
爪におけるセラミド含量増加剤 1.0
100.0wt%
Formulation Example 8: Tablet
Lactose 54.0wt%
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Ceramide content increasing agent in nails 1.0
100.0wt%
配合例9:顆粒内服剤(医薬品)
爪におけるセラミド含量増加剤 1.0wt%
乳糖 30.0
コーンスターチ 60.0
結晶セルロース 8.0
ポリビニールピロリドン 1.0
100.0wt%
Formulation Example 9: Oral granules (pharmaceuticals)
Ceramide content increasing agent in nails 1.0wt%
Lactose 30.0
Cornstarch 60.0
Crystalline cellulose 8.0
Polyvinylpyrrolidone 1.0
100.0wt%
配合例10:キャットフード
とうもろこし 34.0wt%
小麦粉 35.0
ミートミール 15.0
牛脂 8.9
食塩 1.0
かつおエキス 4.0
爪におけるセラミド含量増加剤 1.0
タウリン 0.1
ビタミン類 0.5
ミネラル類 0.5
100.0wt%
Formulation Example 10: Cat food
Corn 34.0wt%
Flour 35.0
Meat meal 15.0
Beef tallow 8.9
Salt 1.0
Skipjack extract 4.0
Ceramide content increasing agent in nails 1.0
Taurine 0.1
Vitamins 0.5
Minerals 0.5
100.0wt%
配合例11:ドッグフード
とうもろこし 30.0wt%
肉類(チキン) 15.0
脱脂大豆 10.0
小麦粉 25.0
糟糠類 5.0
爪におけるセラミド含量増加剤 5.0
動物性油脂 8.9
オリゴ糖 0.1
ビタミン 0.5
ミネラル 0.5
100.0wt%
配合例12:化粧クリーム
スクワラン 20.0wt%
ミツロウ 5.0
精製ホホバ油 5.0
グリセリン 5.0
グリセリンモノステアレート 2.0
ポリオキシエチレン(20)ソルビタン-
モノステアレート 2.0
爪におけるセラミド含量増加剤 2.0
防腐剤 適量
香料 適量
精製水 残余
100.0wt%
Formulation Example 11: Dog food
Corn 30.0wt%
Meat (chicken) 15.0
Defatted soybean 10.0
Flour 25.0
Mosses 5.0
Nerve ceramide content increasing agent 5.0
Animal fats and oils 8.9
Oligosaccharide 0.1
Vitamin 0.5
Mineral 0.5
100.0wt%
Formulation Example 12: Cosmetic cream
Squalane 20.0wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Nail ceramide content increasing agent 2.0
Preservative appropriate amount
Perfume
Purified water residue
100.0wt%
配合例13:化粧水
エタノール 5.0wt%
グリセリン 2.0
1,3−ブチレングリコール 2.0
ポリエチレンオレイルエーテル 0.5
クエン酸ナトリウム 0.1
クエン酸 0.1
爪におけるセラミド含量増加剤 0.1
精製水 残余
100.0wt%
Formulation Example 13: Lotion
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Nerve ceramide content increasing agent 0.1
Purified water residue
100.0wt%
配合例14:ボディージェル
マカデミアナッツ油 2.0wt%
ミリスチン酸オクチルドデシル 10.0
メチルフェニルポリシロキサン 5.0
ベヘニルアルコール 3.0
ステアリン酸 3.0
バチルアルコール 1.0
モノステアリン酸グリセリル 1.0
テトラオレイン酸ポリオキシエチレンソルビット 2.0
水素添加大豆リン脂質 1.0
セラミド 0.1
パルミチン酸レチノール 0.1
防腐剤 適量
ツボクサ抽出物 1.0
爪におけるセラミド含量増加剤 1.0
1、3−ブチレングリコール 5.0
精製水 残余
100.0wt%
Formulation Example 14: Body gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative appropriate amount
Centella extract 1.0
Ceramide content increasing agent in nails 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%
配合例15:乳液
スクワラン 4.0wt%
ワセリン 2.5
セタノール 2.0
グリセリン 2.0
親油型モノステアリン酸グリセリン 1.0
ステアリン酸 1.0
L−アルギニン 1.0
爪におけるセラミド含量増加剤 0.5
水酸化カリウム 0.1
香料 微量
精製水 残余
100.0wt%
Formulation Example 15: Latex
Squalane 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Ceramide content increasing agent in nails 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%
配合例16:浴用剤(液状)
プロピレングリコール 50.0wt%
エタノール 20.0
硫酸ナトリウム 5.0
爪におけるセラミド含量増加剤 0.5
ラノリン 0.5
アボガド油 0.5
色素 1.5
香料 22.0
100.0wt%
Formulation Example 16: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Ceramide content increasing agent in nails 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%
以上により、本発明は、爪におけるセラミド含量を増加させることができ、これにより爪の水分蒸散量を減少させることができる。
As described above, the present invention can increase the ceramide content in the nail, thereby reducing the moisture transpiration of the nail.
Claims (3)
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CN109953926A (en) * | 2019-04-09 | 2019-07-02 | 中美杜克(广州)护肤研究中心(普通合伙) | Five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof |
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JP2006500368A (en) * | 2002-08-21 | 2006-01-05 | アクファーマ インコーポレイテッド | Skin condition treatment composition and method |
JP2007500678A (en) * | 2003-07-31 | 2007-01-18 | ギウリアニ ソシエタ ペル アチオニ | Use of spermine and / or spermidine in dietary, medical or cosmetic compositions for skin aging |
JP2010539157A (en) * | 2007-09-14 | 2010-12-16 | セダーマ | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid |
JP2013060410A (en) * | 2011-08-19 | 2013-04-04 | Oriza Yuka Kk | Keratin expression promoter and composition for manicure using the same |
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2013
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JP2006500368A (en) * | 2002-08-21 | 2006-01-05 | アクファーマ インコーポレイテッド | Skin condition treatment composition and method |
JP2007500678A (en) * | 2003-07-31 | 2007-01-18 | ギウリアニ ソシエタ ペル アチオニ | Use of spermine and / or spermidine in dietary, medical or cosmetic compositions for skin aging |
JP2010539157A (en) * | 2007-09-14 | 2010-12-16 | セダーマ | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid |
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CN109953926A (en) * | 2019-04-09 | 2019-07-02 | 中美杜克(广州)护肤研究中心(普通合伙) | Five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof |
CN109953926B (en) * | 2019-04-09 | 2021-12-31 | 中美杜克(广州)护肤研究中心(普通合伙) | Skin care product with five-vitamin anti-wrinkle and anti-aging effects and preparation method thereof |
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