CN109803663A - 具有多孔赋形剂的鼻用药物组合物 - Google Patents

具有多孔赋形剂的鼻用药物组合物 Download PDF

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Publication number
CN109803663A
CN109803663A CN201780047958.8A CN201780047958A CN109803663A CN 109803663 A CN109803663 A CN 109803663A CN 201780047958 A CN201780047958 A CN 201780047958A CN 109803663 A CN109803663 A CN 109803663A
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composition
active agent
condition
porous
testosterone
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CN201780047958.8A
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Chinese (zh)
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C.马特恩
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Matten Pharmaceutical Co Ltd
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Matten Pharmaceutical Co Ltd
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ceramic Engineering (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
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CN201780047958.8A 2016-06-03 2017-06-02 具有多孔赋形剂的鼻用药物组合物 Pending CN109803663A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345369P 2016-06-03 2016-06-03
US62/345369 2016-06-03
PCT/IB2017/053288 WO2017208209A1 (en) 2016-06-03 2017-06-02 Nasal pharmaceutical compositions with a porous excipient

Publications (1)

Publication Number Publication Date
CN109803663A true CN109803663A (zh) 2019-05-24

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CN201780047958.8A Pending CN109803663A (zh) 2016-06-03 2017-06-02 具有多孔赋形剂的鼻用药物组合物

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Country Link
US (1) US11903951B2 (https=)
EP (1) EP3463375A1 (https=)
JP (2) JP7542309B2 (https=)
KR (1) KR102387241B1 (https=)
CN (1) CN109803663A (https=)
AU (1) AU2017274649B2 (https=)
EA (1) EA201892595A1 (https=)
MX (1) MX389588B (https=)
SG (1) SG11201810628XA (https=)
WO (1) WO2017208209A1 (https=)
ZA (1) ZA201808551B (https=)

Cited By (4)

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CN112263546A (zh) * 2020-09-29 2021-01-26 南京大学 通过鼻腔给药的佐匹克隆混悬液纳米制剂及其制备方法
WO2021109880A1 (zh) * 2019-12-06 2021-06-10 上海医药集团股份有限公司 药物组合物、成套药盒及其应用
CN112972428A (zh) * 2021-03-09 2021-06-18 石河子大学 两性离子聚合物膜包覆的介孔硅基药物载体及制备方法
CN113456576A (zh) * 2021-06-28 2021-10-01 华中科技大学 纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用

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CN110461340A (zh) 2017-01-20 2019-11-15 马特恩制药股份公司 用于降低暴露于空气污染物的风险的鼻用药物组合物
RU2020126425A (ru) 2018-01-11 2022-02-11 М Эт П Фарма Аг Лечение демиелинизирующих заболеваний
CN110545794B (zh) * 2018-01-22 2021-02-26 北京茵诺医药科技有限公司 用于靶向活化cd44分子的胶束纳米载体递送系统、其制备方法和用途
WO2019202504A1 (en) 2018-04-17 2019-10-24 M et P Pharma AG Compositions and methods for intranasal delivery of pregnenolone
EP3837266A1 (en) 2018-08-17 2021-06-23 Massachusetts Institute of Technology Degradable polymers of a cyclic silyl ether and uses thereof
EP4058501A1 (en) 2019-11-15 2022-09-21 Massachusetts Institute of Technology Functional oligomers and functional polymers including hydroxylated polymers and conjugates thereof and uses thereof
RS63725B1 (sr) 2020-05-18 2022-12-30 Orexo Ab Nova farmaceutska kompozicija za davanje leka
JP2021000483A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
JP2021000484A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
JP2021000481A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
CN117062852A (zh) 2021-02-01 2023-11-14 麻省理工学院 可再加工的组合物
GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device
AR127780A1 (es) 2021-11-25 2024-02-28 Orexo Ab Nueva composición farmacéutica que comprende adrenalina
US20230310440A1 (en) * 2022-04-01 2023-10-05 Enalare Therapeutics Inc. Respiratory stimulant nasal formulations
CN115505052B (zh) * 2022-08-23 2023-05-23 安徽普利药业有限公司 一种β-环糊精衍生物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102802610A (zh) * 2008-09-23 2012-11-28 实验室护肤股份有限公司 装载活性剂的均匀、刚性、球形、纳米多孔磷酸钙颗粒及其制备和使用方法
WO2016041992A1 (en) * 2014-09-15 2016-03-24 Grace Gmbh & Co. Kg Active-loaded particulate materials for topical administration

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002597A (en) 1989-04-03 1991-03-26 Invent Ag Aerodynamic filter
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
DE19701912C1 (de) * 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
DE10064950A1 (de) 2000-12-23 2002-07-11 Impetus Ag Basel Thixotropes Nasenspray
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
US7563451B2 (en) * 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
US8784869B2 (en) 2003-11-11 2014-07-22 Mattern Pharma Ag Controlled release delivery system for nasal applications and methods of treatment
ATE319426T1 (de) 2003-11-11 2006-03-15 Mattern Udo Nasenformulierung mit kontrollierter freisetzung von sexualhormonen
US20060140820A1 (en) 2004-12-28 2006-06-29 Udo Mattern Use of a container of an inorganic additive containing plastic material
WO2007041079A2 (en) * 2005-09-30 2007-04-12 Alza Corporation Banded controlled release nanoparticle active agent formulation dosage forms and methods
WO2008040488A1 (en) 2006-10-04 2008-04-10 M & P Patent Aktiengesellschaft Controlled release delivery system for nasal application of neurotransmitters
EP2077754B1 (en) 2006-10-13 2011-03-23 Koninklijke Philips Electronics N.V. Switchable joint constraint system
US8258137B2 (en) * 2008-01-29 2012-09-04 Katholieke Universiteit Leuven Process for release of biologically active species from mesoporous oxide systems
US8778401B2 (en) * 2008-10-28 2014-07-15 Agency For Science, Technology And Research Mesoporous material excipients for poorly aqueous soluble ingredients
US20130040922A1 (en) 2011-05-13 2013-02-14 Trimel Pharmaceuticals Corporation Intranasal 0.45% and 0.48% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
ES2825799T3 (es) 2011-05-13 2021-05-17 Acerus Biopharma Inc Formulaciones en gel de testosterona intranasal de concentración de dosis más baja y uso de las mismas para tratar anorgasmia o trastorno del deseo sexual hipoactivo
KR102568894B1 (ko) * 2011-05-15 2023-08-21 에이세러스 바이오파마 인크. 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
ITTO20111242A1 (it) * 2011-12-30 2013-07-01 Miso S R L Composizioni per il trattamento di patologie delle mucose
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
WO2014076569A2 (en) * 2012-11-14 2014-05-22 Trimel Biopharma Srl Controlled release topical testosterone formulations and methods
US20150290217A1 (en) * 2012-11-21 2015-10-15 Trimel Biopharma Srl Male testosterone titration methods, male intranasal testosterone bio-adhesive gel formulations and use thereof for treating hypogonadism and trt
US9474720B2 (en) * 2013-11-04 2016-10-25 BioPharmX, Inc. Dosage form comprising an active ingredient and a plurality of solid porous microcarriers
EP3331498B1 (en) 2015-08-04 2020-03-11 WindStar Medical GmbH A nasal composition
WO2017042709A1 (en) 2015-09-09 2017-03-16 King Abdullah University Of Science And Technology Functionalized sio2 microspheres for extracting oil from produced water
EP3229549B1 (en) * 2016-04-08 2018-11-21 Panasonic Intellectual Property Corporation of America Procedures for grouping wearable devices with lte master ues
CN110461340A (zh) 2017-01-20 2019-11-15 马特恩制药股份公司 用于降低暴露于空气污染物的风险的鼻用药物组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102802610A (zh) * 2008-09-23 2012-11-28 实验室护肤股份有限公司 装载活性剂的均匀、刚性、球形、纳米多孔磷酸钙颗粒及其制备和使用方法
WO2016041992A1 (en) * 2014-09-15 2016-03-24 Grace Gmbh & Co. Kg Active-loaded particulate materials for topical administration

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021109880A1 (zh) * 2019-12-06 2021-06-10 上海医药集团股份有限公司 药物组合物、成套药盒及其应用
CN112263546A (zh) * 2020-09-29 2021-01-26 南京大学 通过鼻腔给药的佐匹克隆混悬液纳米制剂及其制备方法
CN112263546B (zh) * 2020-09-29 2021-08-10 南京大学 通过鼻腔给药的佐匹克隆混悬液纳米制剂及其制备方法
CN112972428A (zh) * 2021-03-09 2021-06-18 石河子大学 两性离子聚合物膜包覆的介孔硅基药物载体及制备方法
CN112972428B (zh) * 2021-03-09 2022-03-08 石河子大学 两性离子聚合物膜包覆的介孔硅基药物载体及制备方法
CN113456576A (zh) * 2021-06-28 2021-10-01 华中科技大学 纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用

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