CN109561891A - 用于瓣膜夹子切除的方法和装置 - Google Patents

用于瓣膜夹子切除的方法和装置 Download PDF

Info

Publication number
CN109561891A
CN109561891A CN201780047992.5A CN201780047992A CN109561891A CN 109561891 A CN109561891 A CN 109561891A CN 201780047992 A CN201780047992 A CN 201780047992A CN 109561891 A CN109561891 A CN 109561891A
Authority
CN
China
Prior art keywords
clip
conduit
valve
cutting element
leaflet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201780047992.5A
Other languages
English (en)
Other versions
CN109561891B (zh
Inventor
亚历克斯·海尔克哈汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evalve Inc
Original Assignee
Evalve Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evalve Inc filed Critical Evalve Inc
Priority to CN202111032959.XA priority Critical patent/CN113842188B/zh
Publication of CN109561891A publication Critical patent/CN109561891A/zh
Application granted granted Critical
Publication of CN109561891B publication Critical patent/CN109561891B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/10—Surgical instruments, devices or methods, e.g. tourniquets for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/128—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
    • A61B17/1285—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/083—Clips, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00358—Snares for grasping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A61B2017/00783—Valvuloplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00876—Material properties magnetic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A61B2017/22035—Gripping instruments, e.g. forceps, for removing or smashing calculi for retrieving or repositioning foreign objects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/32006—Surgical cutting instruments with a cutting strip, band or chain, e.g. like a chainsaw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00369—Heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00601—Cutting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1407—Loop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/144—Wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种用于接近心脏瓣膜中的相对的瓣叶来切除植入的夹子的系统，该系统包括：捕获导管，该捕获导管构造成在夹子的一侧靠近瓣叶被引入；传输导管，该传输导管构造成在夹子的另一侧靠近瓣叶被引入；以及切割工具，该切割工具构造成被部署在捕获导管与传输导管之间并且构造成靠着瓣叶中的至少一者的组织接合并且构造成切除夹子。可选地，可以使用移除导管将夹子从心脏移除。

Description

用于瓣膜夹子切除的方法和装置
相关申请的交叉引用
本申请要求于2017年7月5日提交的美国专利申请No.15/642,245(代理人案卷号50494-703.201)的优先权，该美国专利申请要求于2016年7月6日提交的临时申请No.62/359,121(代理人案卷号50494-703.101)，和于2016年11月7日提交的临时申请No.62/418,571(代理人案卷号50494-703.102)的权益，这些申请的全部公开内容通过参引并入本文中。
技术领域
本发明总体上涉及医疗装置和方法。更具体地，本发明涉及用于从心脏瓣膜移除夹子和其他植入假体的装置、系统、套件和方法。
背景技术
二尖瓣反流(Mitral regurgitation)是一种常见的瓣膜疾病，并且患病率随着年龄而增长。在这种情况下，血液在心脏收缩期间血液从左心室异常反流到左心房中，并且这种情况会导致许多不良后果，比如由于左心室功能障碍、心房颤动、肺动脉高压引起的心里衰竭以及死亡。公开的指南建议手术或经导管矫正二尖瓣反流，以改善临床状况。
通过植入二尖瓣夹子(特别是来自Abbott Vascular(雅培血管公司)的系统)对二尖瓣反流进行的经导管矫正已经成为用于处于开放式外科矫正手术的高风险患者的标准疗法。这种夹子植入手术通过插入右股静脉中的引导导管来进行。一个或更多个二尖瓣夹子可以通过导引导管被输送并植入以重新接近前二尖瓣瓣叶和后二尖瓣瓣叶(通常被称为“边对边”修复)。二尖瓣夹子是由钴铬合金制成且覆盖有织物网的金属植入物。
迄今为止，在全球范围内已经进行了超过45,000个使用瓣膜夹子的手术，并且目前每个月进行近1000个手术。已发现手术是非常安全的手术并且针对手术风险高的患者提供了治疗选择。
然而，常规的二尖瓣夹合技术存在一些显著的局限性。首先，一旦植入二尖瓣夹子，移除通常需要开放式手术切除。其次，由于技术挑战，并非所有患者在手术时都达到令人满意的MR减少。最后，在手术的6个月内，多达1/5的患者可能有显著的MR返回或者需要重复介入。
如果患者在二尖瓣夹合手术后具有复发性MR，则用于额外治疗的当前选择是有限的。一种选择将是安置另一二尖瓣夹子，但是这通常由于担心产生二尖瓣狭窄而是不可能的(二尖瓣夹子通常使瓣膜变窄，使得瓣膜不再正常打开)。
其他选择包括变得可用的各种二尖瓣修复和置换技术。引人注意的是经导管二尖瓣置换术，在经导管二尖瓣置换术中，安装在可扩张框架上的生物假体二尖瓣被配置在有缺陷的天然二尖瓣中。这种经导管“置换”瓣膜使得二尖瓣反流完全消除并且将模拟二尖瓣置换在选定患者中的手术“黄金标准”。
目前，在已经执行了在前的二尖瓣夹合手术的情况下，可能难以或不可能植入经导管二尖瓣，因为二尖瓣夹子发生干涉并且将不允许新瓣膜完全扩张。因此，将期望提供用于从心脏瓣膜经导管移除夹子和其他植入假体的装置、系统、套件和方法。特别期望的是用于经导管从心脏瓣膜移除夹子和其他植入假体的这些装置、系统、套件和方法将使心脏瓣膜处于接受随后的经导管手术比如人工瓣膜植入的状态，以治疗瓣膜病变。这些目的中的至少一些目的将通过本文中所述描述的本发明来实现。
参见美国专利公开2014/0228871、US2015257883和US2014135799，美国专利Nos.US8500768、US7955340和US5895404，以及以下指南和出版物：Nishimura RA、Otto CM、Bonow RO等人的2014 AHA/ACC guideline for the management of patients withvalvular heart disease(2014年AHA/ACC心脏瓣膜病的患者管理指南)：executivesummary(执行概要)：a report of the American College of Cardiology/AmericanHeart Association Task Force on Practice Guidelines(美国心脏病学会/美国心脏协会实践指南工作组的报告)，J Am Coll Cardiol(美国心脏病学学院杂志)2014；63：2438-88；Feldman T、Kar S、Elmariah S等人的Randomized Comparison of PercutaneousRepair and Surgery for Mitral Regurgitation(经皮修复术与二尖瓣反流手术的随机比较)：5-Year Results of EVEREST II(EVEREST II的5年结果)，J Am Coll Cardiol(美国心脏病学学院杂志)2015；66：2844-54；以及Maisano F、Alfieri O、Banai S等人的Thefuture of transcatheter mitral valve interventions(经导管二尖瓣介入的未来)：Competitive or complementary role of repair vs.replacement？(修复与置换的竞争或补充作用？)，Eur Heart J(欧洲心脏杂志)2015；36：1651-9。
发明内容
本发明提供了可以用于将一个或更多个二尖瓣夹子与天然二尖瓣瓣叶组织分离并且可选地将所述一个或更多个二尖瓣夹子从天然二尖瓣瓣叶组织移除的经导管工具和经导管手术。在这样的手术中，医生可以将专门设计的导管从左心房或左心室插入。导丝可以邻近在先植入的二尖瓣夹子被安置在瓣叶和瓣膜组织周围。利用机械切割或磨损或射频能量，可以将二尖瓣夹子从前瓣叶或后瓣叶或前瓣叶和后瓣叶两者切除，从而恢复天然瓣膜孔口并允许进行将来的修复或置换疗法。在将二尖瓣夹子与天然瓣叶组织分离之后，将预期二尖瓣反流的程度急剧恶化。相比之下，本发明的分离手术可以在进行经导管瓣膜植入或另一经导管矫正手术之前即刻进行。例如，如果使用经心尖接入来部署新的经导管二尖瓣，则可以使用经中隔接入来释放二尖瓣夹子，或者如果使用经中隔接入来部署新的经导管二尖瓣，则可以使用经心尖接入来释放二尖瓣夹子。
在本发明的第一方面，一种用于接近心脏瓣膜中的相对的一对瓣叶来切除夹子的方法包括将捕获导管在夹子的一侧邻近瓣叶引入心脏腔室中。还将传输导管在夹子另一侧邻近瓣叶引入心脏腔室中，并且将切割元件部署在传输导管与捕获导管之间，以将切割元件靠着瓣叶中的至少一者的组织安置或接合。接着使用切割构件将夹子从瓣叶中的至少一者切除，以释放固定并允许瓣叶分开。
本发明的切除方法可以用于下述任何心脏瓣膜：为了增强对合或者出于其他原因，在所述心脏瓣膜处可以将安置有夹子。最典型地，心脏瓣膜为二尖瓣，并且导管可以经中隔被引入瓣膜上方的左心房中，或者可以经心尖地被引入二尖瓣下方的左心室中。在其他情况下，目标心脏瓣膜可以为三尖瓣，并且导管可以被引入三尖瓣上方的右心房或三尖瓣下方的右心室中。
在示例性实施方式中，部署切割构件包括使捕获导管和传输导管中的至少一者并且通常两者的梢端转向，以带动这两个导管的梢端靠近瓣膜夹子。通常，捕获导管和传输导管中的至少一者可以前进穿过瓣叶之间的开口而邻近固定的瓣膜夹子，其中，前进的导管接着可以围绕瓣膜夹子的相反侧转向并且在瓣膜夹子的相反侧被向上带动穿过瓣叶之间的空间。接着可以使切割构件在传输导管与捕获导管之间传递，以跨越瓣叶的要被切除的目标区域。接着可以操纵导管以使切割构件延伸经过瓣膜夹子的一侧，使得切割构件定位成在瓣膜的一侧切除瓣叶的一部分。如下面将更详细描述的，可以将瓣膜夹子留下植入相对的瓣叶中，并且用附接至相对的瓣叶的留置的夹子来进行后续的瓣膜介入手术。替代性地，捕获导管和传输导管可以用于将切割构件重新定位在瓣膜夹子的另一侧，使得可以从夹子切除相对的瓣叶以完全释放夹子并允许在对心脏瓣膜进行后续介入之前将夹子从心脏移除。当释放并移除瓣膜夹子时，当然将必须通常通过如下文中所述的移除导管来约束瓣膜夹子。
在又一些其他具体示例中，切割构件可以通过使捕获导管上的磁性元件靠着切割构件上的磁性元件接合来部署。磁性元件通常位于捕获导管的梢端和切割构件的端部处，并且导管可以被操纵成将切割构件牵拉经过瓣膜夹子的任一侧或两侧以便切除瓣叶组织以释放夹子。
在替代性实施方式中，切割元件可以包括用于捕获切割构件的自由端部的环，并且因此捕获导管可以被操纵成使该环在切割构件的自由端部上行进并且牵拉切割元件经过夹子并穿过瓣膜组织。
在又一些其他实施方式中，部署切割构件可以包括将捕获导管的梢端和传输导管的梢端牵拉在一起以形成经过瓣膜夹子的路径并使元件在该路径上前进。在使切割构件进行这种前进并定位之后，可以操纵捕获导管和/或传输导管以操纵切割构件切除瓣膜组织从而释放夹子。
如上所述，在本发明的方法的一些实施方式中，夹子将被从仅一个瓣叶切除，使得夹子被留下植入相对的瓣叶中。将夹子从至少一个瓣叶释放将至少在一些情况下足以释放相对的瓣叶并且使得能够进行随后的瓣膜置换或其他介入手术。然而，在其他情况下，将优选的是在进行随后的瓣膜植入或其他介入之前将瓣膜夹子完全从心脏瓣膜移除。在这些情况下，在切除期间将通常使用移除导管或其他装置来约束或捕获夹子，并且在任何另外的介入之前将从心脏腔室切除的夹子取出。
在本发明的方法的又一些其他具体实施方式中，夹子可以以各种方式被从瓣叶组织切除。例如，切割构件可以包括电极部段或能够将射频(RF)切割电流输送至组织的其他导电区域。特别地，RF电流将在切割模式下输送，使得切割构件可以将与瓣膜夹子相邻的瓣膜组织切除。在其他情况下，切割构件可以包括可以用于机械切穿瓣膜组织的尖锐或研磨区域。例如，尖锐或研磨切割区域可以进行往复运动，以便其“锯”穿组织以切除瓣膜。也可以采用其他已知的组织切割方式。
如上所述，捕获导管、传输导管和切割构件用于切除单个瓣叶的组织，使得瓣膜夹子附接至相对的瓣叶。尽管将瓣膜夹子从单个瓣叶移除将允许瓣叶充分打开以便于进行随后的假体瓣膜植入或其他矫正手术，但是有时将期望的是将瓣膜夹子从两个相对的瓣叶移除。在这种情况下，将优选的是将夹子移除导管引入心脏腔室中以便使最终移除的瓣膜夹子稳定。夹子移除导管的远端部可以靠着夹子接合并且通常将附接至夹子，同时使用切割构件将夹子从一个瓣叶或两个瓣叶切除。
在又一些其他示例性实施方式中，捕获导管、传输导管和可选的夹子移除导管通常可以同时通过经中隔导管或护套而经中隔被引入。在又一些其他具体实施方式中，捕获导管、传输导管和可选的夹子移除导管通常可以同时通过经心尖护套或导管而经心尖被引入。
在本发明的第二方面中，一种用于接近心脏瓣膜中的相对的瓣叶来切除植入的夹子的系统包括捕获导管、传输导管和切割构件。捕获导管构造成在夹子的一侧邻近瓣叶被引入心脏腔室中。传输导管构造成在夹子的另一侧邻近瓣叶被引入心脏腔室中，并且切割构件构造成被从传输导管部署至捕获导管以将切割元件靠着瓣叶中的至少一者的组织安置以切除夹子。
在该系统的具体方面，捕获导管和传输导管中的至少一者将具有可转向的梢端，通常两者都具有可转向的梢端。捕获导管将通常具有磁性远端梢端，该磁性远端梢端构造成接合并捕获设置在切割构件的远端部处的磁性元件。以此方式，捕获导管上的磁性梢端可以用于吸引并接合切割构件的磁性端部，使得切割构件可以被部署在捕获导管与传输导管之间。因此，切割构件的切割区域可以定位成接合与瓣膜夹子相邻的瓣叶组织，使得切割区域可以用于切割组织并切除夹子。例如，切割区域可以包括可用于机械切割瓣膜组织的尖锐或研磨区域。替代性地，切割区域可以包括RF电极，该RF电极可以被以切割电流供电以切除与夹子相邻的瓣叶组织。
本发明的系统还可以包括用于将本发明的导管输送至心脏腔室的引导护套，该引导护套通常为经中隔护套或经心尖护套。通常，引导护套将大到足以同时至少容置捕获导管和传输导管。通常，该系统将还包括移除导管，并且引导护套将定尺寸成大到足以同时容置捕获导管、传输导管和移除导管中的每一者。
本发明的夹子移除导管通常将具有构造成接合并捕获夹子的远端部。某些瓣膜夹子、比如瓣膜夹子具有提供“对接”特征的独特形状，本发明的夹子移除导管和可选的其他导管可以使用该“对接”特征，以与瓣膜夹子的心房或心室方面“对接”。瓣膜夹子的形状通常易于通过荧光镜检查看清楚，这便于在移除手术期间瞄准移除导管或其他导管并且可选地将移除导管或其他导管与夹子对接。这种对接具有若干个优点。第一，对接可以使瓣膜夹子相对于导管系统稳定，这是有利的，因为瓣膜在不停跳心脏手术期间运动。第二，对接便于使导管定向以改善切割构件的位置、例如使切割线材成环，使得切割线材使用上面所示的磁性技术或勒除器技术而环绕夹子。第三，通过将移除导管或其他导管与瓣膜夹子对接，导管和切割构件可以稳定地定位在瓣膜夹子附近，从而使弦装置被环形线材或其他切割构件缠绕或勒除的风险最小化。第四，对接可以从心房方面或心室方面进行。例如，心房对接可以通过对接到夹子的“Y”形部分的顶部的凹槽中来实现。心室对接可以通过与夹子的“Y”形部分的底部对接来实现。对接可以是被动的、例如经由过盈配合进行，或者可以在移除导管或其他导管具有用以牢固地附接夹子的“抓持”特征的情况下是主动的。通过修改对接特征，对接可以在各个瓣膜夹子上单独进行或者在若干个瓣膜夹子上同时进行。
本发明的移除导管可以设计成与MitraClip或其他瓣膜夹子对接，以环绕夹子安置勒除器。在使用前述导管将夹子从前瓣叶和后瓣叶(或在三尖瓣的情况下的中隔瓣叶)释放之后，夹子可以通过移除导管穿过接入护套被从身体移除。移除导管可以具有在瓣膜夹子被从两个瓣叶释放之后固定瓣膜夹子以保持瓣膜夹子从而可以将瓣膜夹子从身体移除的各种夹子抓持特征中的任一者，比如勒除器、活检型钳或卡爪。捕获导管和/或传输导管还可以构造成与瓣膜夹子对接，例如，捕获导管和/或传输导管的远端梢端具有与瓣膜夹子的形状互补的形状。移除夹子的导管可以通过经静脉的经中隔方法或左心室经心尖方法安置。在一些情况下，移除导管可以设计成具有呈漏斗形形状的梢端，以允许瓣膜夹子以适当的取向被牵拉到导管中。
本发明的导管系统还可以用于环绕并移除起搏器的引线或除颤器的引线。例如，通过使环绕引线的环沿着引线的长度滑动，引线可以被从供其植入的心脏或血管组织切除。特别地，本发明的导管可以用于将引线从血管静脉组织、比如腋静脉、头臂静脉和/或上腔静脉释放。本发明的导管还可以用于将引线从三尖瓣或右心室心肌释放。特别地，在引线可能引起三尖瓣反流(TR)的情况下，可以将引线从三尖瓣释放。引线可选地被重新定位以减少TR。导管还可以用于释放导线以允许导线根据需要重新定位在三尖瓣孔口中，以便于将经导管瓣膜安置在三尖瓣位置中。
在所附权利要求中阐述了被认为是说明性示例的特征的新颖特征。然而，当结合附图阅读时，通过参照本公开的说明性示例的以下详细描述，这些说明性示例将被最好地理解，在附图中：
附图说明
图1和图1A示出了二尖瓣的在植入二尖瓣夹子之后的解剖结构。
图2A和图2B示出了根据本发明的原理构造的捕获导管，该捕获导管具有以其伸直构型(图2A)和偏转构型(图2B)示出的可操纵远端区域。
图3示出了根据本发明的原理构造的传输导管。
图4示出了在本发明的方法中与捕获导管和传输导管一起使用的切割构件。
图5A至图5E示出了捕获导管上的磁性梢端和切割构件上的磁性远端元件的不同实施方式。
图6示出了根据本发明的替代性系统，该替代性系统包括在其远端部具有捕获环的捕获导管。
图7A至图7F示出了根据本发明的原理的在用于移除植入二尖瓣中的一对夹子的方法中使用捕获导管和传输导管。
图8示出了根据本发明的原理将捕获导管和传输导管经心尖引入到左心房中以切除二尖瓣中的瓣膜夹子。
图9A至图9C示出了根据本发明的原理的在用于从三尖瓣移除瓣膜夹子的方法中使用捕获导管和传输导管。
图10A至图10E示出了根据本发明的原理的在用于从二尖瓣移除单个瓣膜夹子的方法中使用捕获导管和传输导管。
具体实施方式
本发明提供了用于将一个或更多个瓣膜夹子与二尖瓣和其他心脏瓣叶分离的装置和方法。瓣膜夹子可以位于沿着瓣膜对合平面的任何位置(中央、内侧、外侧或连合处)，并且在一些实施方式中，瓣膜夹子被从对合瓣叶中的一者移除并同时被留置于对合瓣叶中的另一者中。在其他实施方式中，瓣膜夹子将被从两个瓣叶移除并被完全从心脏抽出。
本发明的技术可以从左心房方面(经中隔或直接心房进入)或者从左心室方面(经心尖、直接心室穿刺或逆主动脉进入)部署。切割动作可以由“勒除器”、类似剪刀的装置、类似于“奶酪切割器”的基于线的切割器、射频电极切割元件等来提供。在一些情况下，二尖瓣夹子可以从前瓣叶和后瓣叶两者移除，并且可以使用勒除器、活检钳型装置或其他移除导管将二尖瓣夹子从身体完全移除。本发明可以用于从三尖瓣以及二尖瓣移除瓣膜夹子，并且这些导管通过经中隔导管和经心尖导管来安置，经中隔导管和经心尖导管通常大到足以容置在手术中同时使用的所有导管。
现在参照图1和图1A，瓣膜夹子C可以被植入心脏H中的二尖瓣MV以及三尖瓣TV的瓣叶中。二尖瓣MV将左心房LA与左心室LV分开，并且三尖瓣TV将右心房RA与右心室RV分开。为了完整性，应指出的是，血液从左心室LV通过主动脉瓣瓣膜AV流入主动脉A中。如图1A中更详细地所示，二尖瓣MV中的夹子C可以位于前瓣叶AL与后瓣叶PL之间的瓣膜开口的中间附近。然而，夹子C也可以植入在瓣叶之间的远离瓣膜开口中间的其他位置处。
现在参照图2A和图2B，捕获导管10包括轴12，轴12具有近端部14和远端部16。轴的近端部附接有控制把手18，并且在该把手的远端处设置有偏转旋钮20。捕获导管10通常还包括冲洗端口22并且将具有适于接纳导丝24的中央管腔，导丝24在其远端部具有可成形梢端26。如特别图2B中所示，导管的轴12的远端区域28将是可主动偏转或“可转向”的，使得该区域可以偏转达180°，如所示的。这种偏转将由偏转旋钮20和下述适合的偏转机构或任何其他常规的导管偏转技术来控制：所述偏转机构可以包括拉线并且在轴的远端部处具有开槽区域。
现在参照图3，传输导管34包括轴36，轴36具有近端部38和远端部40。该轴的近端部附接有控制把手42，并且在控制把手42的远端部设置有偏转旋钮44。传输导管34也可以包括冲洗端口46并且将通常具有与上面针对捕获导管10所描述梢端类似的可转向的远端梢端48。
现在参照图4，切割构件50包括长形本体52，长形本体52通常具有线状构型(在如下所述的电外科切割构件的情况下通常是导电的)，使得该长形本体可以通过传输导管34的前进管腔来给送。切割构件50还包括切割区域54，切割区域54通常跨越长形本体的长度的中间附近的区域并且通常具有0.5cm至数厘米的长度，并且切割区域54的两侧通常由不透射线标记物56结合。在电外科切割构件的情况下，该构件可以包括导电线材，其中，切割区域未被绝缘并且切割区域两侧的区域被电绝缘。在长形本体52的一个端部将通常设置有磁性远端元件58，并且如图3中所示，当切割构件50被装载到传输导管34上时，磁性远端元件58将从该导管的远端梢端40向外伸出，使得磁性远端元件58露出并且可用于磁性吸引捕获导管10的磁性梢端30，如下面所描述的。
如图5A至图5E中所示，捕获导管10的磁性梢端30可以采用各种形式。磁性梢端30a(图5A)呈子弹形状并且具有用于容置捕获导管的导丝的贯穿管腔。磁性梢端30b呈盘状形状并且也具有容置捕获导管中的导丝的贯通管腔。
切割构件50的磁性远端元件58也可以具有各种构型。最简单地，磁性远端元件58将具有如图5E中所示的球形形状。替代性地，磁性远端元件可以具有如图5B中所示的子弹形状58a或如图5D中所示的盘状形状58b。
如上所述，捕获导管10和切割构件50将各自具有磁性元件以允许由捕获导管50捕获切割构件。尽管这是优选设计，但是也可以采用各种其他捕获机构。例如，如图6中所示，捕获导管62可以在其远端部处承载捕获环66。然后，可以使用捕获环来捕获由传输导管64承载的切割构件72的自由端部70。也可以使用钩、倒钩、线圈靶等，以允许由捕获导管捕获切割构件。
现在参照图7A至图7F，将描述使用捕获导管10和传输导管34经由经中隔进路将一对夹子C1和C2从二尖瓣MV移除。导丝24的可转向的远端梢端28首先通过经中隔护套74被引入二尖瓣上方的左心房中。梢端28可以在心脏不停跳的情况下于荧光镜导引下在夹子C1与C2之间前进。可选地，捕获导管10可以用于辅助将导丝24在导管10于导丝上前进之前安置在夹子之间。导丝可以是被动的或主动的。
在导丝被安置之后，如图7A中所示，捕获导管10可以在导丝24上前进，使得捕获导管10定位在夹子C1和C2上方，如图7B中所示。接着，捕获导管10的远端部在夹子C1与C2之间前进，使得磁性梢端进入左心室，如图7C中所示。接着，传输导管34可以通过经中隔护套74与捕获导管10平行地被引入并转向以使切割构件50上的磁性远端元件58b前进，从而使得磁性远端元件58b与捕获导管10上的磁性梢端30接合。例如，传输导管34的可转向的远端区域48可以在前瓣叶AL与后瓣叶PL之间向下前进并且被操纵成使磁性远端元件58b靠着磁性梢端30接合。
在切割构件50与捕获导管10联接在一起之后，捕获导管10可以被往回拉以使切割区域54露出，并且导管被操纵成使切割区域54靠着第二瓣膜夹子C2接合，如图7E中所示。接着，切割区域54被操纵成锯穿后瓣叶PL在夹子C2周围的组织或者以电外科手术切割后瓣叶PL在夹子C2周围的组织。接着可以重复该过程以将第一夹子C1从后瓣叶PL切除，如图7F中所示，从而导致二尖瓣打开以允许进行假体瓣膜植入或其他介入。尽管在图7A至图7F中示出了后瓣叶的切除，但是在某些情况下，将优选的是切除前瓣叶组织从而使夹子附接至后瓣叶。
现在参照图8，也可以使用捕获导管10和传输导管34通过经心尖护套78来执行将瓣膜夹子C从二尖瓣MV切除。使用经心尖方法，导管10的远端梢端和导管34的远端梢端从左心室LV向上前进至左心房LA，并且接着大体如前所述的那样使用导管切除组织。
现在参照图9A至图9C，将描述切除植入三尖瓣TV的前瓣叶AL与中隔瓣叶SL之间的瓣膜夹子C。捕获导管10和传输导管34可以通过接入护套80被引入三尖瓣上方的右心房中，如图9B中所示。导管10和34可以用于将切割构件50的切割区域54于夹子C的一侧定位在中隔瓣叶SL中，如图9C所示。接着可以以前述任何方式操纵切割构件50，以切除中隔瓣叶SL的组织以释放夹子C并打开三尖瓣，如图9C中所示。在对瓣膜进行后续介入之前，也可以将夹子C的被植入前瓣叶中的部分切除，或者可以使夹子留在原位。
现在参照图10A至图10E，大体如前所示的，可以通过使用经中隔护套74将捕获导管10和传输导管34引入左心房中来将单个瓣膜夹子C从二尖瓣MV移除。另外，可以通过经中隔护套74将夹子移除导管90与捕获导管10和传输导管34同时通过引入，以便接合夹子C并使夹子C变稳定。如图10A中所示，可以将位于操纵线材92的远端部处的夹子捕获元件94输送穿过夹子移除导管90的管腔以捕获夹子C的上表面。接着使用切割构件50的切割区域54来切除前瓣叶AL中的组织且同时通过夹子移除导管90来保持并稳定夹子，从而将夹子从前瓣叶释放，如图10B中所示(其中，为了便于说明而移除了捕获导管10和传输导管34)。接着可以对捕获导管34和传输导管10进行重新定位，如图10C中所示，使得切割构件50的切割区域54靠着后瓣叶PL定位，并且接着可以操纵切割区域以切除后瓣叶中组织，从而释放夹子，如图10D中所示。接着可以使用继续保持夹子C的夹子移除导管90将夹子C从二尖瓣取出，如图10E所示。于是，二尖瓣MV完全不具有植入的夹子，以便接纳二尖瓣假体或者进行另一矫正介入。
尽管已经详细描述了本公开的某些实施方式，但是某些变型和改型对于本领域技术人员而言将是明显的，包括没有提供本文中所描述的所有特征和益处的实施方式。本领域技术人员将理解的是，本公开超出了具体公开的实施方式并且延伸到了本发明的其他替代性或附加的实施方式和/或用途以及其明显的改型和等同物。另外，尽管已经以不同的细节示出且描述了许多变型，但是本领域技术人员基于本公开将容易明白在本公开的范围内的其他改型。还可以预期的是，可以进行实施方式的具体特征和方面的各种组合或子组合并且仍然落在本公开的范围内。因此，应当理解的是，所公开的实施方式的各种特征和方面可以彼此组合或替代，以形成本公开的不同模式。因此，预期本文中所公开的本公开的范围不应受上述公开的特定实施方式的限制。对于上述所有实施方式，任何方法的步骤不需要按顺序执行。

Claims (30)

1.一种用于接近心脏瓣膜中的相对的一对瓣叶来切除夹子的方法，所述方法包括：
将捕获导管在所述夹子的一侧邻近所述瓣叶引入心脏腔室中；
将传输导管在所述夹子另一侧邻近所述瓣叶引入所述心脏腔室中；
将切割元件从所述传输导管至所述捕获导管部署，以将所述切割元件靠着所述瓣叶中的至少一者的组织安置；
使所述切割构件靠着所述瓣叶的组织接合；并且
使用所述切割构件将所述夹子从至少一个瓣叶切除。
2.根据权利要求1所述的方法，其中，所述心脏腔室为左心房，并且所述心脏瓣膜为二尖瓣。
3.根据权利要求1所述的方法，其中，所述心脏腔室为左心室，并且所述心脏瓣膜为二尖瓣。
4.根据权利要求1所述的方法，其中，所述心脏腔室为右心房，并且所述心脏瓣膜为三尖瓣。
5.根据权利要求1所述的方法，其中，所述心脏腔室为右心室，并且所述心脏瓣膜为三尖瓣。
6.根据权利要求1所述的方法，其中，部署所述切割元件包括使所述捕获导管和所述传输导管中的至少一者的梢端转向，以使这两个导管的梢端靠近。
7.根据权利要求6所述的方法，其中，部署所述切割构件还包括使所述捕获导管上的磁性元件靠着所述切割构件上的磁性元件接合并牵拉所述切割构件经过所述瓣膜。
8.根据权利要求6所述的方法，其中，部署所述切割元件还包括使所述捕获导管上的环接合在所述切割构件上的自由端部上并牵拉所述切割构件经过所述瓣膜。
9.根据权利要求6所述的方法，其中，部署所述切割元件还包括将所述捕获导管的梢端和所述传输导管的梢端带至一起，以形成经过所述瓣膜的路径并使所述切割构件前进穿过所述路径。
10.根据权利要求1所述的方法，其中，所述夹子被从仅一个瓣叶切除。
11.根据权利要求1所述的方法，其中，所述夹子被从所述相对的一对瓣叶两者切除。
12.根据权利要求1所述的方法，其中，将所述夹子从至少一个瓣叶切除包括输送射频电流通过所述切割构件。
13.根据权利要求1所述的方法，其中，将所述夹子从至少一个瓣叶切除包括用所述切割构件机械切割或研磨所述瓣膜的组织。
14.根据权利要求1所述的方法，还包括将夹子移除导管引入所述心脏腔室中并且在使用所述切割构件将所述夹子从至少一个瓣叶切除的同时使所述夹子移除导管的远端部靠着所述夹子接合。
15.根据权利要求1所述的方法，还包括将所述夹子从相对的两个瓣膜切除并用夹子移除导管移除所述夹子。
16.根据权利要求1所述的方法，其中，所述捕获导管和所述传输导管是经中隔引入的。
17.根据权利要求1所述的方法，其中，所述捕获导管和所述传输导管是经心尖引入的。
18.一种用于接近心脏瓣膜中的相对的瓣叶来切除植入的夹子的系统，所述系统包括：
捕获导管，所述捕获导管构造成在所述夹子的一侧邻近所述瓣叶被引入心脏腔室中；
传输导管，所述传输导管构造成在所述夹子的另一侧邻近所述瓣叶被引入所述心脏腔室中；以及
切割构件，所述切割构件构造成从所述传输导管至所述捕获导管部署，以将所述切割元件靠着所述瓣叶中的至少一者的组织安置以切除所述夹子。
19.根据权利要求18所述的系统，其中，所述捕获导管和所述传输导管中的至少一者具有可转向的远端梢端。
20.根据权利要求18所述的系统，其中，所述捕获导管和所述传输导管中的每一者均具有可转向的远端梢端。
21.根据权利要求18所述的系统，其中，所述捕获导管具有磁性远端梢端。
22.根据权利要求21所述的系统，其中，所述切割构件由所述传输导管承载并且具有磁性元件，所述磁性元件在所述传输导管的远端部处露出，使得对所述导管在心脏腔室内的位置的操纵允许所述捕获导管捕获所述切割构件。
23.根据权利要求18所述的系统，还包括夹子移除导管，所述夹子移除导管具有构造成接合并捕获所述夹子的远端部。
24.根据权利要求18所述的系统，其中，所述切割构件包括射频电极以用于通电切割瓣膜组织。
25.根据权利要求18所述的系统，其中，所述切割构件包括机械研磨或尖锐边缘以用于机械切割瓣膜组织。
26.根据权利要求18所述的系统，其中，所述切割构件包括由不透射线标记物描绘的切割区域。
27.根据权利要求18所述的系统，还包括构造成将所述捕获导管和所述传输导管引导至所述心脏腔室的输送护套。
28.根据权利要求18所述的系统，其中，所述输送护套具有定尺寸成同时容置所述捕获导管和所述传输导管两者的管腔。
29.根据权利要求18所述的系统，其中，所述输送护套包括经中隔护套。
30.根据权利要求18所述的系统，其中，所述输送护套包括经心尖护套。
CN201780047992.5A 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置 Active CN109561891B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111032959.XA CN113842188B (zh) 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662359121P 2016-07-06 2016-07-06
US62/359,121 2016-07-06
US201662418571P 2016-11-07 2016-11-07
US62/418,571 2016-11-07
US15/642,245 2017-07-05
US15/642,245 US10736632B2 (en) 2016-07-06 2017-07-05 Methods and devices for valve clip excision
PCT/US2017/040977 WO2018009718A1 (en) 2016-07-06 2017-07-06 Methods and devices for valve clip excision

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202111032959.XA Division CN113842188B (zh) 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置

Publications (2)

Publication Number Publication Date
CN109561891A true CN109561891A (zh) 2019-04-02
CN109561891B CN109561891B (zh) 2021-09-28

Family

ID=60892878

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202111032959.XA Active CN113842188B (zh) 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置
CN201780047992.5A Active CN109561891B (zh) 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202111032959.XA Active CN113842188B (zh) 2016-07-06 2017-07-06 用于瓣膜夹子切除的方法和装置

Country Status (7)

Country Link
US (2) US10736632B2 (zh)
EP (2) EP3791795B1 (zh)
JP (3) JP2019520917A (zh)
CN (2) CN113842188B (zh)
CR (1) CR20190042A (zh)
SG (1) SG11201811457QA (zh)
WO (1) WO2018009718A1 (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113230000A (zh) * 2021-05-27 2021-08-10 应脉医疗科技(上海)有限公司 一种瓣膜夹子移除系统
CN113993572A (zh) * 2019-07-25 2022-01-28 创新心有限公司 用于在心脏瓣膜周围布置导丝的装置
CN114081674A (zh) * 2021-09-28 2022-02-25 四川大学华西医院 一种瓣叶分割装置
CN114642480A (zh) * 2020-12-18 2022-06-21 应脉医疗科技(上海)有限公司 一种瓣膜夹子切除装置
US12076233B2 (en) 2019-07-25 2024-09-03 Innovheart S.R.L. Device for implanting a prosthesis for a heart valve and assembly procedure

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9572666B2 (en) 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
CN108601645B (zh) 2015-12-15 2021-02-26 内奥瓦斯克迪亚拉公司 经中隔递送系统
EP4183372A1 (en) 2016-01-29 2023-05-24 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11963712B2 (en) 2016-06-20 2024-04-23 Evalve, Inc. Transapical removal device
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. METHODS AND SYSTEMS FOR RAPID RETRACTION OF A TRANSCATHETER HEART VALVE DELIVERY SYSTEM
WO2021072331A1 (en) * 2019-10-09 2021-04-15 Nasser Rafiee Tissue excision, cutting, and removal systems and methods
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
WO2019040943A1 (en) 2017-08-25 2019-02-28 Lederman Robert J CATHETERS AND MANIPULATORS WITH ARTICULATED END
US20210212756A1 (en) * 2017-08-25 2021-07-15 Nasser Rafiee Tissue cutting systems and methods
EP3784173A4 (en) 2018-04-24 2021-12-15 Raghuveer Basude RECOVERABLE TISSUE PREHENSION DEVICES, SPACERS, ARTIFICIAL VALVES AND RELATED PROCESSES
US12102531B2 (en) * 2018-10-22 2024-10-01 Evalve, Inc. Tissue cutting systems, devices and methods
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CA3132873A1 (en) 2019-03-08 2020-09-17 Neovasc Tiara Inc. Retrievable prosthesis delivery system
CN113811265A (zh) 2019-04-01 2021-12-17 内奥瓦斯克迪亚拉公司 能够以可控的方式部署的假体瓣膜
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11000300B2 (en) * 2019-04-22 2021-05-11 Atrial Systems, Llc Magnetically coupled vascular snare system and method
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11534303B2 (en) 2020-04-09 2022-12-27 Evalve, Inc. Devices and systems for accessing and repairing a heart valve
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
CN114302698A (zh) 2019-07-15 2022-04-08 埃瓦尔维公司 近端元件致动器的固定和释放机构
WO2021011653A1 (en) 2019-07-15 2021-01-21 Evalve, Inc. Independent proximal element actuation methods
JP7566004B2 (ja) 2019-07-15 2024-10-11 エバルブ，インコーポレイティド 非変形ウィングを持つワイドクリップ
US11707228B2 (en) 2019-09-26 2023-07-25 Evalve, Inc. Systems and methods for intra-procedural cardiac pressure monitoring
US11464636B2 (en) 2019-10-11 2022-10-11 Evalve, Inc. Repair clip for variable tissue thickness
WO2021092107A1 (en) 2019-11-06 2021-05-14 Evalve, Inc. Stabilizer for a medical delivery system
WO2021092460A1 (en) 2019-11-08 2021-05-14 Evalve, Inc. Medical device delivery system with locking system
WO2021097124A1 (en) 2019-11-14 2021-05-20 Evalve, Inc. Catheter assembly with coaptation aid and methods for valve repair
WO2021097089A1 (en) 2019-11-14 2021-05-20 Evalve, Inc. Kit with coaptation aid and fixation system and methods for valve repair
EP4076285A1 (en) 2019-12-18 2022-10-26 Evalve, Inc. Wide clip with deformable width
US20230105063A1 (en) * 2020-03-03 2023-04-06 W. L. Gore & Associates, Inc. Transcatheter tissue cutting system
US12048448B2 (en) 2020-05-06 2024-07-30 Evalve, Inc. Leaflet grasping and cutting device
US20210346089A1 (en) * 2020-05-06 2021-11-11 Evalve, Inc. Systems and methods for leaflet cutting using a hook catheter
US20210346090A1 (en) * 2020-05-06 2021-11-11 Evalve, Inc. Devices and methods for clip separation
US20210346081A1 (en) * 2020-05-06 2021-11-11 Evalve, Inc. Devices and methods for leaflet cutting
US20210401434A1 (en) * 2020-06-24 2021-12-30 Medtronic Vascular, Inc. Apparatus and methods for removal of heart valve ligation clip
US11337753B2 (en) * 2020-07-03 2022-05-24 Telltale Llc Tissue cutting systems and methods
US20220079754A1 (en) 2020-09-16 2022-03-17 Evalve, Inc. Device and procedure for mitral valve clip removal and subsequent delivery of a transcatheter mitral valve implantation
US20220361907A1 (en) * 2021-05-14 2022-11-17 Evalve, Inc. Systems and methods for separating native heart valve leaflets attached together by a fixation device
EP4374808A1 (en) * 2022-11-25 2024-05-29 Universität Linz Catheter assembly for slitting a dissection membrane of an aorta

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955340B2 (en) * 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8257356B2 (en) * 2004-10-15 2012-09-04 Baxano, Inc. Guidewire exchange systems to treat spinal stenosis
US20140228871A1 (en) * 2011-09-28 2014-08-14 Mitracore Technologies Inc. Apparatuses and methods for cutting a tissue bridge and/or removing a heart valve clip or suture
CN104244841A (zh) * 2012-03-06 2014-12-24 海莱夫简易股份公司 具备环绕功能的医疗导管件
US9126032B2 (en) * 2010-12-13 2015-09-08 Pacesetter, Inc. Pacemaker retrieval systems and methods
US20150257883A1 (en) * 2014-03-17 2015-09-17 Evalve, Inc. Mitral valve fixation device removal devices and methods

Family Cites Families (633)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1996261A (en) 1933-06-17 1935-04-02 Charles R Storz Adenotome
US2097018A (en) 1936-07-17 1937-10-26 Coleman R Chamberlin Multiple purpose guide and retention clip
US2108206A (en) 1937-03-09 1938-02-15 Lillian Pearl Mecker Tenaculum
US3296668A (en) 1965-03-03 1967-01-10 Winthrop J Aiken Clip for sheets and the like
US3378010A (en) 1965-07-28 1968-04-16 Coldling Surgical clip with means for releasing the clamping pressure
US3470875A (en) 1966-10-06 1969-10-07 Alfred A Johnson Surgical clamping and suturing instrument
US3557780A (en) 1967-04-20 1971-01-26 Olympus Optical Co Mechanism for controlling flexure of endoscope
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3675639A (en) 1970-05-11 1972-07-11 Hugo S Cimber Device for and method of temporary sterilizing a female
US3874338A (en) 1972-10-09 1975-04-01 Fritz Happel Milking cup
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
GB1486351A (en) 1975-06-06 1977-09-21 Rocket Of London Ltd Surgical clip applicator
US4007743A (en) 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4112951A (en) 1976-01-26 1978-09-12 Research Corporation Surgical clip
US4091815A (en) 1976-07-06 1978-05-30 Larsen Otis M Flexible tube clamp
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
AU521676B2 (en) 1977-02-23 1982-04-22 Clark, Richard Edwin Heart valve prosthesis
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4235238A (en) 1978-05-11 1980-11-25 Olympus Optical Co., Ltd. Apparatus for suturing coeliac tissues
NL7906691A (nl) 1979-09-07 1981-03-10 Jansen Anton Medische inrichting vor het koppelen van twee darm- gedeelten, hulpinrichting ten gebruike daarbij en werk- wijze voor het leggen van een darmknoop met behulp van deze inrichting.
US4312337A (en) 1980-09-08 1982-01-26 Donohue Brian T Cannula and drill guide apparatus
US4578061A (en) 1980-10-28 1986-03-25 Lemelson Jerome H Injection catheter and method
US4498476A (en) 1981-08-27 1985-02-12 Ethicon, Inc. Non-metallic, bio-compatible hemostatic clips with interlocking latch means
US4944295A (en) 1981-10-21 1990-07-31 Owen Gwathmay Suturing assembly
US4809695A (en) 1981-10-21 1989-03-07 Owen M. Gwathmey Suturing assembly and method
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4487205A (en) 1982-04-26 1984-12-11 Ethicon, Inc. Non-metallic, bio-compatible hemostatic clips
US4484579A (en) 1982-07-19 1984-11-27 University Of Pittsburgh Commissurotomy catheter apparatus and method
US4458682A (en) 1982-08-02 1984-07-10 Ethicon, Inc. Non-metallic, bio-compatible hemostatic clips (ring lock clips)
US4510934A (en) 1983-05-13 1985-04-16 Batra Subhash K Suture
US4531522A (en) 1983-06-20 1985-07-30 Ethicon, Inc. Two-piece tissue fastener with locking top and method for applying same
DE3344934A1 (de) 1983-12-13 1985-06-20 Richard Wolf Gmbh, 7134 Knittlingen Endoskop mit distal ablenkbarem hilfsinstrument
GB8424582D0 (en) 1984-09-28 1984-11-07 Univ Glasgow Heart valve prosthesis
JPS6187434A (ja) 1984-10-04 1986-05-02 Nec Corp 携帯無線機
DE3504292C1 (de) 1985-02-08 1986-07-24 Richard Wolf Gmbh, 7134 Knittlingen Instrument fuer endoskopische Eingriffe,insbesondere zur perkutanen Gallensteinentfernung oder Gallenblasenveroedung
CA1303298C (en) 1986-08-06 1992-06-16 Alain Carpentier Flexible cardiac valvular support prosthesis
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
US5542949A (en) 1987-05-14 1996-08-06 Yoon; Inbae Multifunctional clip applier instrument
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
JPH088933B2 (ja) 1987-07-10 1996-01-31 日本ゼオン株式会社 カテ−テル
US4872455A (en) 1987-11-25 1989-10-10 Corvita Corporation Anastomosis trimming device and method of using the same
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5447966A (en) 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US4917089A (en) 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US5108368A (en) 1990-01-04 1992-04-28 Pilot Cardiovascular System, Inc. Steerable medical device
US5069679A (en) 1989-02-16 1991-12-03 Taheri Syde A Method and apparatus for removing venous valves
US4994077A (en) 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5078723A (en) 1989-05-08 1992-01-07 Medtronic, Inc. Atherectomy device
US5620461A (en) 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5092872A (en) 1989-07-28 1992-03-03 Jacob Segalowitz Valvulotome catheter
US5047041A (en) 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US5071428A (en) 1989-09-08 1991-12-10 Ventritex, Inc. Method and apparatus for providing intrapericardial access and inserting intrapericardial electrodes
GB8924806D0 (en) 1989-11-03 1989-12-20 Neoligaments Ltd Prosthectic ligament system
US5049153A (en) 1989-12-26 1991-09-17 Nakao Naomi L Endoscopic stapling device and method
US5015249A (en) 1989-12-26 1991-05-14 Nakao Naomi L Endoscopic stapling device and method
US6033378A (en) 1990-02-02 2000-03-07 Ep Technologies, Inc. Catheter steering mechanism
US5820591A (en) 1990-02-02 1998-10-13 E. P. Technologies, Inc. Assemblies for creating compound curves in distal catheter regions
US5195968A (en) 1990-02-02 1993-03-23 Ingemar Lundquist Catheter steering mechanism
WO1991015155A1 (fr) 1990-04-02 1991-10-17 Kanji Inoue Procede pour refermer une ouverture de shunt au moyen d'un procede sans operateur
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (da) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5001136A (en) 1990-06-07 1991-03-19 Pfizer Inc. Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines
US5078722A (en) 1990-08-14 1992-01-07 Cordis Corporation Method and apparatus for removing deposits from a vessel
US5389102A (en) 1990-09-13 1995-02-14 United States Surgical Corporation Apparatus and method for subcuticular stapling of body tissue
US5053043A (en) 1990-09-28 1991-10-01 Vance Products Incorporated Suture guide and method of placing sutures through a severed duct
US5282845A (en) 1990-10-01 1994-02-01 Ventritex, Inc. Multiple electrode deployable lead
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
US5125758A (en) 1990-12-06 1992-06-30 Dewan Thomas E Piercing clamp
US5275578A (en) 1991-01-11 1994-01-04 Adams Andy W Clip
US5163955A (en) 1991-01-24 1992-11-17 Autogenics Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment
DE9100873U1 (de) 1991-01-25 1991-04-18 Wisap Gesellschaft für wissenschaftlichen Apparatebau mbH, 8029 Sauerlach Rundrohr-Morcellator
US5171252A (en) 1991-02-05 1992-12-15 Friedland Thomas W Surgical fastening clip formed of a shape memory alloy, a method of making such a clip and a method of using such a clip
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
US5217460A (en) 1991-03-22 1993-06-08 Knoepfler Dennis J Multiple purpose forceps
US5251611A (en) 1991-05-07 1993-10-12 Zehel Wendell E Method and apparatus for conducting exploratory procedures
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5304131A (en) 1991-07-15 1994-04-19 Paskar Larry D Catheter
US6623449B2 (en) 1991-07-15 2003-09-23 Larry D. Paskar Catheter with up-going and down-going configurations
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5769812A (en) 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5452733A (en) 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5571215A (en) 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5226911A (en) 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5336227A (en) 1991-11-05 1994-08-09 Wilk & Nakao Medical Technology Incorporated Surgical cauterization snare with polyp capturing web net
DE4137218C1 (zh) 1991-11-13 1993-02-11 Heidmueller, Harald, 5000 Koeln, De
US5271381A (en) 1991-11-18 1993-12-21 Vision Sciences, Inc. Vertebrae for a bending section of an endoscope
US5242456A (en) 1991-11-21 1993-09-07 Kensey Nash Corporation Apparatus and methods for clamping tissue and reflecting the same
US5234437A (en) 1991-12-12 1993-08-10 Target Therapeutics, Inc. Detachable pusher-vasoocclusion coil assembly with threaded coupling
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5423882A (en) 1991-12-26 1995-06-13 Cordis-Webster, Inc. Catheter having electrode with annular recess and method of using same
AU3803193A (en) 1991-12-30 1994-09-26 Wellesley Research Associates, Inc. Dental implant system and apparatus
US5489297A (en) 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5417700A (en) 1992-03-30 1995-05-23 Thomas D. Egan Automatic suturing and ligating device
US5314424A (en) 1992-04-06 1994-05-24 United States Surgical Corporation Surgical instrument locking mechanism
US5190554A (en) 1992-04-08 1993-03-02 Eastern Virginia Medical School Appendix extractor
US5318525A (en) 1992-04-10 1994-06-07 Medtronic Cardiorhythm Steerable electrode catheter
US5254130A (en) 1992-04-13 1993-10-19 Raychem Corporation Surgical device
US5368601A (en) 1992-04-30 1994-11-29 Lasersurge, Inc. Trocar wound closure device
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5389098A (en) 1992-05-19 1995-02-14 Olympus Optical Co., Ltd. Surgical device for stapling and/or fastening body tissues
US5658300A (en) 1992-06-04 1997-08-19 Olympus Optical Co., Ltd. Tissue fixing surgical instrument, tissue-fixing device, and method of fixing tissues
US5325845A (en) 1992-06-08 1994-07-05 Adair Edwin Lloyd Steerable sheath for use with selected removable optical catheter
US5306283A (en) 1992-06-30 1994-04-26 American Cyanamid Company Two-part surgical ligation clip
US5368606A (en) 1992-07-02 1994-11-29 Marlow Surgical Technologies, Inc. Endoscopic instrument system
US5342393A (en) 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
US5383886A (en) 1992-10-13 1995-01-24 Kensey Nash Corporation Methods and instruments for performing medical procedures percutaneously without a trocar
US6048351A (en) 1992-09-04 2000-04-11 Scimed Life Systems, Inc. Transvaginal suturing system
US5713910A (en) 1992-09-04 1998-02-03 Laurus Medical Corporation Needle guidance system for endoscopic suture device
US5312415A (en) 1992-09-22 1994-05-17 Target Therapeutics, Inc. Assembly for placement of embolic coils using frictional placement
US5350397A (en) 1992-11-13 1994-09-27 Target Therapeutics, Inc. Axially detachable embolic coil assembly
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
CA2106126A1 (en) 1992-09-23 1994-03-24 Ian M. Scott Bipolar surgical instruments
WO1994006357A1 (en) 1992-09-23 1994-03-31 Target Therapeutics, Inc. Medical retrieval device
US5500180A (en) 1992-09-30 1996-03-19 C. R. Bard, Inc. Method of making a distensible dilatation balloon using a block copolymer
US5330442A (en) 1992-10-09 1994-07-19 United States Surgical Corporation Suture retaining clip
US6283127B1 (en) 1992-12-03 2001-09-04 Wesley D. Sterman Devices and methods for intracardiac procedures
US5718725A (en) 1992-12-03 1998-02-17 Heartport, Inc. Devices and methods for intracardiac procedures
US5462527A (en) 1993-06-29 1995-10-31 C.R. Bard, Inc. Actuator for use with steerable catheter
US6036699A (en) 1992-12-10 2000-03-14 Perclose, Inc. Device and method for suturing tissue
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5702825A (en) 1992-12-22 1997-12-30 Essilor International (Compagnie Generale D'optique) Low yellow index polymer compositions, polymerizable compositions and lenses using said compositions
US5403312A (en) 1993-07-22 1995-04-04 Ethicon, Inc. Electrosurgical hemostatic device
US5368564A (en) 1992-12-23 1994-11-29 Angeion Corporation Steerable catheter
US5403326A (en) 1993-02-01 1995-04-04 The Regents Of The University Of California Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux
DE9301616U1 (de) 1993-02-05 1994-06-01 W.L. Gore & Associates Gmbh, 85640 Putzbrunn Flexibler Katheter
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
WO1994018893A1 (en) 1993-02-22 1994-09-01 Valleylab, Inc. A laparoscopic dissection tension retractor device and method
US5980455A (en) 1993-02-22 1999-11-09 Heartport, Inc. Method for manipulating a tissue structure within a thoracic cavity
US5425705A (en) 1993-02-22 1995-06-20 Stanford Surgical Technologies, Inc. Thoracoscopic devices and methods for arresting the heart
US5972030A (en) 1993-02-22 1999-10-26 Heartport, Inc. Less-invasive devices and methods for treatment of cardiac valves
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
US5456400A (en) 1993-04-22 1995-10-10 United States Surgical Corporation Apparatus and clip for fastening body tissue
FR2705556A1 (fr) 1993-05-28 1994-12-02 Leclerc Yves Couteau chirurgical.
DE4319829C1 (de) 1993-06-16 1994-08-25 Lerch Karl Dieter Set zur Behandlung von Gefäßmißbildungen
US5715817A (en) 1993-06-29 1998-02-10 C.R. Bard, Inc. Bidirectional steering catheter
US5549565A (en) 1993-07-13 1996-08-27 Symbiosis Corporation Reusable surgical trocar with disposable valve assembly
US5527321A (en) 1993-07-14 1996-06-18 United States Surgical Corporation Instrument for closing trocar puncture wounds
US5391182A (en) 1993-08-03 1995-02-21 Origin Medsystems, Inc. Apparatus and method for closing puncture wounds
US5507755A (en) 1993-08-03 1996-04-16 Origin Medsystems, Inc. Apparatus and method for closing puncture wounds
CA2125258C (en) 1993-08-05 1998-12-22 Dinah B Quiachon Multicapsule intraluminal grafting system and method
US5450860A (en) 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
EP0720440B1 (en) 1993-09-20 2003-11-05 Boston Scientific Corporation Multiple biopsy sampling device
US5423858A (en) 1993-09-30 1995-06-13 United States Surgical Corporation Septoplasty fasteners and device for applying same
US5496333A (en) 1993-10-20 1996-03-05 Applied Medical Resources Corporation Laparoscopic surgical clamp
US5472044A (en) 1993-10-20 1995-12-05 E. I. Du Pont De Nemours And Company Method and apparatus for interacting a gas and liquid on a convoluted array of tubes
US5423857A (en) 1993-11-02 1995-06-13 Ethicon, Inc. Three piece surgical staple
US6203531B1 (en) 1993-11-03 2001-03-20 Daig Corporation Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach
US5640955A (en) 1995-02-14 1997-06-24 Daig Corporation Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach
US5527322A (en) 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5437681A (en) 1994-01-13 1995-08-01 Suturtek Inc. Suturing instrument with thread management
GB9400739D0 (en) 1994-01-15 1994-03-16 Femcare Ltd Medical clip
US5741280A (en) 1994-01-18 1998-04-21 Coral Medical Knot tying method and apparatus
US5359994A (en) 1994-01-24 1994-11-01 Welch Allyn, Inc. Proximal steering cable adjustment
US5501698A (en) 1994-02-14 1996-03-26 Heartport, Inc. Endoscopic microsurgical instruments and methods
CA2141911C (en) 1994-02-24 2002-04-23 Jude S. Sauer Surgical crimping device and method of use
US5431666A (en) 1994-02-24 1995-07-11 Lasersurge, Inc. Surgical suture instrument
US5476470A (en) 1994-04-15 1995-12-19 Fitzgibbons, Jr.; Robert J. Trocar site suturing device
JPH10503387A (ja) 1994-04-21 1998-03-31 メッドケム・プロダクツ・インコーポレーテッド 単一針皮膚引き伸し装置
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
DE4418766C2 (de) 1994-05-28 1996-11-07 Karlsruhe Forschzent Chirurgischer Faden zum Anlegen einer chirurgischen Naht
US5732872A (en) 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5593435A (en) 1994-07-29 1997-01-14 Baxter International Inc. Distensible annuloplasty ring for surgical remodelling of an atrioventricular valve and nonsurgical method for post-implantation distension thereof to accommodate patient growth
US5593424A (en) 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5601576A (en) 1994-08-10 1997-02-11 Heartport Inc. Surgical knot pusher and method of use
US5456684A (en) 1994-09-08 1995-10-10 Hutchinson Technology Incorporated Multifunctional minimally invasive surgical instrument
US5496332A (en) 1994-10-20 1996-03-05 Cordis Corporation Wound closure apparatus and method for its use
US5599305A (en) 1994-10-24 1997-02-04 Cardiovascular Concepts, Inc. Large-diameter introducer sheath having hemostasis valve and removable steering mechanism
US5814029A (en) 1994-11-03 1998-09-29 Daig Corporation Guiding introducer system for use in ablation and mapping procedures in the left ventricle
US5487746A (en) 1994-11-23 1996-01-30 Yu; George W. Surgical clip having a longitudinal opening through which clamped tissue protrudes
US6180059B1 (en) 1995-06-05 2001-01-30 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5620452A (en) 1994-12-22 1997-04-15 Yoon; Inbae Surgical clip with ductile tissue penetrating members
US5643295A (en) 1994-12-29 1997-07-01 Yoon; Inbae Methods and apparatus for suturing tissue
US5609598A (en) 1994-12-30 1997-03-11 Vnus Medical Technologies, Inc. Method and apparatus for minimally invasive treatment of chronic venous insufficiency
US6540755B2 (en) 1995-02-14 2003-04-01 Daig Corporation Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
JPH08231444A (ja) 1995-02-28 1996-09-10 Daikin Ind Ltd １，１，１，３，３−ペンタフルオロプロパンの製造方法
US5695505A (en) 1995-03-09 1997-12-09 Yoon; Inbae Multifunctional spring clips and cartridges and applicators therefor
US5571085A (en) 1995-03-24 1996-11-05 Electro-Catheter Corporation Steerable open lumen catheter
WO1996030072A1 (en) 1995-03-30 1996-10-03 Heartport, Inc. System and methods for performing endovascular procedures
US5849005A (en) 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
US5626607A (en) 1995-04-03 1997-05-06 Heartport, Inc. Clamp assembly and method of use
US5639277A (en) 1995-04-28 1997-06-17 Target Therapeutics, Inc. Embolic coils with offset helical and twisted helical shapes
US5540705A (en) 1995-05-19 1996-07-30 Suturtek, Inc. Suturing instrument with thread management
US5562678A (en) 1995-06-02 1996-10-08 Cook Pacemaker Corporation Needle's eye snare
US5846253A (en) 1995-07-14 1998-12-08 C. R. Bard, Inc. Wound closure apparatus and method
US5860990A (en) 1995-08-24 1999-01-19 Nr Medical, Inc. Method and apparatus for suturing
US6117144A (en) 1995-08-24 2000-09-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
US6562052B2 (en) 1995-08-24 2003-05-13 Sutura, Inc. Suturing device and method
DE19534112A1 (de) 1995-09-14 1997-03-20 Wolf Gmbh Richard Endoskopisches Instrument
US5722421A (en) 1995-09-15 1998-03-03 Symbiosis Corporation Clevis having deflection limiting stops for use in an endoscopic biopsy forceps instrument
US5797927A (en) 1995-09-22 1998-08-25 Yoon; Inbae Combined tissue clamping and suturing instrument
US5810876A (en) 1995-10-03 1998-09-22 Akos Biomedical, Inc. Flexible forceps device
US5634932A (en) 1995-10-10 1997-06-03 Industrial & Scientific Designs, Ltd. Cantilever aneurysm clip system
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
JP3293118B2 (ja) 1995-10-18 2002-06-17 ニプロ株式会社 心腔内縫合手術用カテーテル組立体
WO1997016119A1 (en) 1995-10-30 1997-05-09 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5855271A (en) 1995-11-03 1999-01-05 T. K. F., Inc. Noise and wear reducing apparatus for endless conveyors
US5704898A (en) 1995-11-17 1998-01-06 Circon Corporation Articulation mechanism for an endoscope
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
JP2963037B2 (ja) 1995-11-30 1999-10-12 三洋電機株式会社 ディスク記録再生装置
US5662704A (en) 1995-12-01 1997-09-02 Medtronic, Inc. Physiologic mitral valve bioprosthesis
US5725556A (en) 1995-12-15 1998-03-10 M & R Medical, Inc. Suture locking apparatus
US5749828A (en) 1995-12-22 1998-05-12 Hewlett-Packard Company Bending neck for use with invasive medical devices
US5810853A (en) 1996-01-16 1998-09-22 Yoon; Inbae Knotting element for use in suturing anatomical tissue and methods therefor
US6015417A (en) 1996-01-25 2000-01-18 Reynolds, Jr.; Walker Surgical fastener
US6182664B1 (en) 1996-02-19 2001-02-06 Edwards Lifesciences Corporation Minimally invasive cardiac valve surgery procedure
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US6162233A (en) 1996-02-23 2000-12-19 Cardiovascular Technologies, Llc Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners
US5891160A (en) 1996-02-23 1999-04-06 Cardiovascular Technologies, Llc Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery
US5895417A (en) 1996-03-06 1999-04-20 Cardiac Pathways Corporation Deflectable loop design for a linear lesion ablation apparatus
US5879307A (en) 1996-03-15 1999-03-09 Pulse Metric, Inc. Non-invasive method and apparatus for diagnosing and monitoring aortic valve abnormalities, such a aortic regurgitation
JP3661267B2 (ja) 1996-03-18 2005-06-15 フジノン株式会社 内視鏡の可撓管
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5769859A (en) 1996-04-09 1998-06-23 Dorsey; William R. Umbilical scissors
US5738649A (en) 1996-04-16 1998-04-14 Cardeon Corporation Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart
US6110145A (en) 1996-04-16 2000-08-29 Cardeon Corporation Catheter system for surgical access and circulatory support of the heart
US6149660A (en) 1996-04-22 2000-11-21 Vnus Medical Technologies, Inc. Method and apparatus for delivery of an appliance in a vessel
US5662681A (en) 1996-04-23 1997-09-02 Kensey Nash Corporation Self locking closure for sealing percutaneous punctures
US5706824A (en) 1996-05-20 1998-01-13 Symbiosis Corporation Endoscopic biopsy forceps instrument having a constant force spring biasing the jaws closed
US5827237A (en) 1996-06-17 1998-10-27 Cardeon Corporation Dual lumen catheter with controlled antegrade and retrograde fluid flow
US5833671A (en) 1996-06-17 1998-11-10 Cardeon Corporation Triple lumen catheter with controllable antegrade and retrograde fluid flow
US6059757A (en) 1996-06-18 2000-05-09 Cardeon Single lumen catheter with controlled antegrade and retrograde flow
WO1997048436A2 (en) 1996-06-17 1997-12-24 Cardeon Corporation Externally valved catheter for controlled antegrade and retrograde fluid flow
US6001796A (en) 1996-07-03 1999-12-14 Alliedsignal Inc. Azeotrope-like compositions of 1,1,1,3,3-pentafluoropropane and hydrogen fluoride
US5820592A (en) 1996-07-16 1998-10-13 Hammerslag; Gary R. Angiographic and/or guide catheter
US5782845A (en) 1996-07-31 1998-07-21 Shewchuk; Dwight Trocar site suturing device
US5820631A (en) 1996-08-01 1998-10-13 Nr Medical, Inc. Device and method for suturing tissue adjacent to a blood vessel
US5669919A (en) 1996-08-16 1997-09-23 Medtronic, Inc. Annuloplasty system
US6068628A (en) 1996-08-20 2000-05-30 Oratec Interventions, Inc. Apparatus for treating chondromalacia
WO1998007375A1 (en) 1996-08-22 1998-02-26 The Trustees Of Columbia University Endovascular flexible stapling device
US5713911A (en) 1996-10-03 1998-02-03 United States Surgical Corporation Surgical clip
US5820630A (en) 1996-10-22 1998-10-13 Annex Medical, Inc. Medical forceps jaw assembly
US7052493B2 (en) 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US5861003A (en) 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
EP1011460A4 (en) 1996-12-02 2001-09-19 Angiotrax Inc APPARATUS AND METHODS SUITABLE FOR PERCUTANEOUS SURGERY
IL119911A (en) 1996-12-25 2001-03-19 Niti Alloys Tech Ltd Surgical clip
US6406420B1 (en) 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6077214A (en) 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US6050936A (en) 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
US6074401A (en) 1997-01-09 2000-06-13 Coalescent Surgical, Inc. Pinned retainer surgical fasteners, instruments and methods for minimally invasive vascular and endoscopic surgery
US5928224A (en) 1997-01-24 1999-07-27 Hearten Medical, Inc. Device for the treatment of damaged heart valve leaflets and methods of using the device
US5916213A (en) 1997-02-04 1999-06-29 Medtronic, Inc. Systems and methods for tissue mapping and ablation
US6056769A (en) 1997-02-11 2000-05-02 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US5972020A (en) 1997-02-14 1999-10-26 Cardiothoracic Systems, Inc. Surgical instrument for cardiac valve repair on the beating heart
US5989284A (en) 1997-02-18 1999-11-23 Hearten Medical, Inc. Method and device for soft tissue modification
US5843103A (en) 1997-03-06 1998-12-01 Scimed Life Systems, Inc. Shaped wire rotational atherectomy device
US5885271A (en) 1997-03-14 1999-03-23 Millennium Cardiac Strategies, Inc. Device for regional immobilization of a compliant body
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US5876399A (en) 1997-05-28 1999-03-02 Irvine Biomedical, Inc. Catheter system and methods thereof
US5810849A (en) 1997-06-09 1998-09-22 Cardiologics, L.L.C. Device and method for suturing blood vessels and the like
EP0930845B1 (en) 1997-06-27 2009-10-14 The Trustees Of Columbia University In The City Of New York Apparatus for circulatory valve repair
IT1293068B1 (it) 1997-07-01 1999-02-11 Kempro Italiana S R L Procedimento per ottenere una sospensione di silice colloidale ad elevata concentrazione e prodotto cosi' ottenuto
US5944733A (en) 1997-07-14 1999-08-31 Target Therapeutics, Inc. Controlled detachable vasoocclusive member using mechanical junction and friction-enhancing member
US6090118A (en) 1998-07-23 2000-07-18 Mcguckin, Jr.; James F. Rotational thrombectomy apparatus and method with standing wave
US6039748A (en) 1997-08-05 2000-03-21 Femrx, Inc. Disposable laparoscopic morcellator
US5910148A (en) 1997-08-06 1999-06-08 Mitek Surgical Products, Inc. Suture retrograder
AU758370B2 (en) 1997-08-08 2003-03-20 Duke University Compositions, apparatus and methods for facilitating surgical procedures
US6174322B1 (en) 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6088889A (en) 1997-09-03 2000-07-18 Edward Elson Clamp operable as a hemostasis valve
US20030105519A1 (en) 1997-09-04 2003-06-05 Roland Fasol Artificial chordae replacement
US6123699A (en) 1997-09-05 2000-09-26 Cordis Webster, Inc. Omni-directional steerable catheter
US6267761B1 (en) 1997-09-09 2001-07-31 Sherwood Services Ag Apparatus and method for sealing and cutting tissue
US5954732A (en) 1997-09-10 1999-09-21 Hart; Charles C. Suturing apparatus and method
FR2768324B1 (fr) 1997-09-12 1999-12-10 Jacques Seguin Instrument chirurgical permettant, par voie percutanee, de fixer l'une a l'autre deux zones de tissu mou, normalement mutuellement distantes
US6019722A (en) 1997-09-17 2000-02-01 Guidant Corporation Device to permit offpump beating heart coronary bypass surgery
US6063106A (en) 1997-09-19 2000-05-16 Gibson; William Frits Stewart Surgical spacer
JPH1189937A (ja) 1997-09-19 1999-04-06 Atsuo Mori 僧帽弁逆流試験用カテーテル
US5916147A (en) 1997-09-22 1999-06-29 Boury; Harb N. Selectively manipulable catheter
US5895404A (en) 1997-09-29 1999-04-20 Ruiz; Carlos E. Apparatus and methods for percutaneously forming a passageway between adjacent vessels or portions of a vessel
US5908420A (en) 1997-10-03 1999-06-01 Everest Medical Corporation Surgical scissors with bipolar distal electrodes
US6086600A (en) 1997-11-03 2000-07-11 Symbiosis Corporation Flexible endoscopic surgical instrument for invagination and fundoplication
US6187003B1 (en) 1997-11-12 2001-02-13 Sherwood Services Ag Bipolar electrosurgical instrument for sealing vessels
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
AU1923999A (en) 1998-01-30 1999-08-16 Vascular Science Inc. Medical graft connector or plug structures, and methods of making and installingsame
US6562037B2 (en) 1998-02-12 2003-05-13 Boris E. Paton Bonding of soft biological tissues by passing high frequency electric current therethrough
US6126658A (en) 1998-02-19 2000-10-03 Baker; James A. Radiofrequency medical instrument and methods for vessel welding
US7214230B2 (en) 1998-02-24 2007-05-08 Hansen Medical, Inc. Flexible instrument
US6190408B1 (en) 1998-03-05 2001-02-20 The University Of Cincinnati Device and method for restructuring the heart chamber geometry
EP1484025A1 (en) 1998-03-05 2004-12-08 Boston Scientific Limited Catheter assembly with electrode
US6511492B1 (en) 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
US6099553A (en) 1998-05-21 2000-08-08 Applied Medical Resources Corporation Suture clinch
US6165164A (en) 1999-03-29 2000-12-26 Cordis Corporation Catheter for injecting therapeutic and diagnostic agents
US6143024A (en) 1998-06-04 2000-11-07 Sulzer Carbomedics Inc. Annuloplasty ring having flexible anterior portion
US6599311B1 (en) 1998-06-05 2003-07-29 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6283962B1 (en) 1998-06-08 2001-09-04 Quantum Therapeutics Corp. Device for valvular annulus treatment and methods thereof
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
US6630001B2 (en) 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6066146A (en) 1998-06-24 2000-05-23 Carroll; Brendan J. Laparascopic incision closure device
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
JP4080161B2 (ja) 1998-07-08 2008-04-23 アクシーア メディカル インコーポレイテッド 結節部なしに縫合部及び結紮部を保持するための用具及び方法
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US7569062B1 (en) 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
WO2000003651A1 (en) 1998-07-15 2000-01-27 Corazon Technologies, Inc. Methods and devices for reducing the mineral content of vascular calcified lesions
US6547821B1 (en) 1998-07-16 2003-04-15 Cardiothoracic Systems, Inc. Surgical procedures and devices for increasing cardiac output of the heart
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6139508A (en) 1998-08-04 2000-10-31 Endonetics, Inc. Articulated medical device
US6267781B1 (en) 1998-08-31 2001-07-31 Quantum Therapeutics Corp. Medical device and methods for treating valvular annulus
US6159240A (en) 1998-08-31 2000-12-12 Medtronic, Inc. Rigid annuloplasty device that becomes compliant after implantation
WO2000012168A1 (en) 1998-09-01 2000-03-09 Cardeon Corporation System and methods for catheter procedures with circulatory support in high risk patients
US6203553B1 (en) 1999-09-08 2001-03-20 United States Surgical Stapling apparatus and method for heart valve replacement
US6355030B1 (en) 1998-09-25 2002-03-12 Cardiothoracic Systems, Inc. Instruments and methods employing thermal energy for the repair and replacement of cardiac valves
US6368326B1 (en) 1998-09-28 2002-04-09 Daos Limited Internal cord fixation device
US6685627B2 (en) 1998-10-09 2004-02-03 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence heart function
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
JP3708356B2 (ja) 1998-11-20 2005-10-19 株式会社モリタ製作所 組織採取切除器及びこれに使用する切除用鉗子
US6319250B1 (en) 1998-11-23 2001-11-20 C.R. Bard, Inc Tricuspid annular grasp catheter
DE19858512C1 (de) 1998-12-18 2000-05-25 Storz Karl Gmbh & Co Kg Bipolares medizinisches Instrument
US6210419B1 (en) 1998-12-18 2001-04-03 Aesculap Ag & Co. Kg Surgical clip
US6558418B2 (en) 1999-01-26 2003-05-06 Edwards Lifesciences Corporation Flexible heart valve
DK1154738T3 (da) 1999-01-27 2010-07-26 Medtronic Inc Indretninger til hjerteklapindgreb
US8282573B2 (en) 2003-02-24 2012-10-09 Senorx, Inc. Biopsy device with selectable tissue receiving aperture orientation and site illumination
US6701929B2 (en) 1999-03-03 2004-03-09 Hany Hussein Device and method for treatment of congestive heart failure
US6136010A (en) 1999-03-04 2000-10-24 Perclose, Inc. Articulating suturing device and method
US6267746B1 (en) 1999-03-22 2001-07-31 Biosense Webster, Inc. Multi-directional steerable catheters and control handles
JP3425387B2 (ja) 1999-03-29 2003-07-14 有限会社タカタデザインラボ 物品の固定具
AU4055700A (en) 1999-04-01 2000-10-23 David B. Bjerken Vacuum-assisted remote suture placement system
US6077277A (en) 1999-04-05 2000-06-20 Starion Instruments, Inc. Suture welding device
DE60045096D1 (de) 1999-04-09 2010-11-25 Evalve Inc Verfahren und vorrichtung zur herzklappenreperation
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7226467B2 (en) 1999-04-09 2007-06-05 Evalve, Inc. Fixation device delivery catheter, systems and methods of use
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US6860179B2 (en) 1999-05-03 2005-03-01 Irwin Industrial Tool Company Clamp device
US6709382B1 (en) 1999-05-04 2004-03-23 Simon Marcus Horner Cardiac assist method and apparatus
US6206907B1 (en) 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
WO2000067641A1 (en) 1999-05-11 2000-11-16 Williamson Warren P Iv Surgical clamp devices and methods especially useful in cardiac surgery
US6165204A (en) 1999-06-11 2000-12-26 Scion International, Inc. Shaped suture clip, appliance and method therefor
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
DE60044531D1 (de) 1999-06-25 2010-07-22 Vahid Saadat Gerät zur gewebebehandlung
SE514718C2 (sv) 1999-06-29 2001-04-09 Jan Otto Solem Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten
US6997951B2 (en) 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
DE19932565A1 (de) 1999-07-13 2001-01-18 Henkel Kgaa Mittel zum Färben von keratinhaltigen Fasern
US7887477B2 (en) 1999-08-09 2011-02-15 Cardiokinetix, Inc. Method of improving cardiac function using a porous membrane
US6197043B1 (en) 1999-08-18 2001-03-06 James A. Davidson Isoelastic suture material and device
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6306133B1 (en) 1999-10-02 2001-10-23 Quantum Cor Incorporated Ablation catheter system and methods for repairing a valvular annulus
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
US20030069570A1 (en) 1999-10-02 2003-04-10 Witzel Thomas H. Methods for repairing mitral valve annulus percutaneously
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
AU5598300A (en) 1999-10-13 2001-04-23 Jeffrey E. Yeung Non-invasive and minimally invasive methods and devices for treating urinary incontinence or obstruction
US6491511B1 (en) 1999-10-14 2002-12-10 The International Heart Institute Of Montana Foundation Mold to form stent-less replacement heart valves from biological membranes
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US7004970B2 (en) 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
EP1674040A3 (en) 1999-10-21 2007-09-19 Edwards Lifesciences Corporation Minimally invasive mitral valve repair
WO2001028455A1 (en) 1999-10-21 2001-04-26 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6533767B2 (en) 2000-03-20 2003-03-18 Corazon Technologies, Inc. Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
US6926730B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Minimally invasive valve repair procedure and apparatus
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6641592B1 (en) 1999-11-19 2003-11-04 Lsi Solutions, Inc. System for wound closure
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
AU2435801A (en) 1999-12-23 2001-07-09 Edwards Lifesciences Corporation Enhanced visualization of medical implants
AU2001229476A1 (en) 2000-01-14 2001-07-24 Viacor Incorporated Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same
US20010010005A1 (en) 2000-01-24 2001-07-26 Kammerer Gene W. Meniscal repair device
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
US6517550B1 (en) 2000-02-02 2003-02-11 Board Of Regents, The University Of Texas System Foreign body retrieval device
US6540782B1 (en) 2000-02-02 2003-04-01 Robert V. Snyders Artificial heart valve
JP2004500206A (ja) 2000-03-03 2004-01-08 シー・アール・バード・インク 縫合糸クリップ、供給装置および方法
TW465542U (en) 2000-03-14 2001-11-21 Tange Seiki Taichung Co Ltd Improved structure for bearing alignment of concealed operation head joint of bicycle
EP1294422B1 (en) 2000-03-20 2010-02-24 Cordis Corporation Medical System for Reducing Vascular Occlusions
US6858005B2 (en) 2000-04-03 2005-02-22 Neo Guide Systems, Inc. Tendon-driven endoscope and methods of insertion
US6530897B2 (en) 2000-04-28 2003-03-11 Mahase Nardeo Steerable medical catheter with bendable encapsulated metal spring tip fused to polymeric shaft
US7083628B2 (en) 2002-09-03 2006-08-01 Edwards Lifesciences Corporation Single catheter mitral valve repair device and method for use
US6743239B1 (en) 2000-05-25 2004-06-01 St. Jude Medical, Inc. Devices with a bendable tip for medical procedures
US6730016B1 (en) 2000-06-12 2004-05-04 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6840246B2 (en) 2000-06-20 2005-01-11 University Of Maryland, Baltimore Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures inside of a beating heart
US6358277B1 (en) 2000-06-21 2002-03-19 The International Heart Institute Of Montana Foundation Atrio-ventricular valvular device
AU2001271411A1 (en) 2000-06-23 2002-01-08 Viacor Incorporated Automated annular plication for mitral valve repair
EP1401358B1 (en) 2000-06-30 2016-08-17 Medtronic, Inc. Apparatus for performing a procedure on a cardiac valve
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
SE0002878D0 (sv) 2000-08-11 2000-08-11 Kimblad Ola Device and method for treatment of atrioventricular regurgitation
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
AU2001287144A1 (en) 2000-09-07 2002-03-22 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20020035381A1 (en) 2000-09-18 2002-03-21 Cameron Health, Inc. Subcutaneous electrode with improved contact shape for transthoracic conduction
US20050228422A1 (en) 2002-11-26 2005-10-13 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US20060106456A9 (en) 2002-10-01 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US20060252984A1 (en) 2000-09-20 2006-11-09 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US7527646B2 (en) 2000-09-20 2009-05-05 Ample Medical, Inc. Devices, systems, and methods for retaining a native heart valve leaflet
US20050222489A1 (en) 2003-10-01 2005-10-06 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant
US20080091264A1 (en) 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US8784482B2 (en) 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US8956407B2 (en) 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US7033374B2 (en) 2000-09-26 2006-04-25 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6419640B1 (en) 2000-10-03 2002-07-16 Thomas V. Taylor Multiple-specimen, endoscopic biopsy forceps
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6918917B1 (en) 2000-10-10 2005-07-19 Medtronic, Inc. Minimally invasive annuloplasty procedure and apparatus
US6533796B1 (en) 2000-10-11 2003-03-18 Lsi Solutions, Inc. Loader for surgical suturing instrument
EP1326672A4 (en) 2000-10-18 2007-03-07 Nmt Medical Inc FIXING AND DETACHING MECHANISM FOR WIRE JUNCTION
US6607538B1 (en) 2000-10-18 2003-08-19 Microvention, Inc. Mechanism for the deployment of endovascular implants
US6508828B1 (en) 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US6974476B2 (en) * 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US20020077687A1 (en) 2000-12-14 2002-06-20 Ahn Samuel S. Catheter assembly for treating ischemic tissue
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
US8323228B2 (en) 2007-04-12 2012-12-04 Rex Medical L.P. Dialysis catheter
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
JP4195612B2 (ja) 2001-01-30 2008-12-10 エドワーズ ライフサイエンシーズ アーゲー 管外組織構造を改善する医療システム及び方法
WO2002062263A2 (en) 2001-02-05 2002-08-15 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
WO2002062408A2 (en) 2001-02-05 2002-08-15 Viacor, Inc. Method and apparatus for improving mitral valve function
JP2001239212A (ja) 2001-02-06 2001-09-04 Matsushita Electric Ind Co Ltd 振動発生モータ
US20020107531A1 (en) 2001-02-06 2002-08-08 Schreck Stefan G. Method and system for tissue repair using dual catheters
US6723109B2 (en) 2001-02-07 2004-04-20 Karl Storz Endoscopy-America, Inc. Deployable surgical clamp with delivery/retrieval device and actuator
US7842050B2 (en) 2001-02-26 2010-11-30 Diduch David R Suture passing devices
JP4295925B2 (ja) 2001-03-01 2009-07-15 Ｈｏｙａ株式会社 内視鏡用バイポーラ高周波処置具
US6585761B2 (en) 2001-03-01 2003-07-01 Syde A. Taheri Prosthetic vein valve and method
DE10116168A1 (de) 2001-03-31 2001-11-29 Joachim Heinzl Verfahren und Einrichtung zum Klippsen mit dem Endoskop
US20060069429A1 (en) 2001-04-24 2006-03-30 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US6619291B2 (en) 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
WO2002092148A2 (en) 2001-05-17 2002-11-21 The Regents Of The University Of California Retrieval catheter
US6858039B2 (en) 2002-07-08 2005-02-22 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
US20020173811A1 (en) 2001-05-21 2002-11-21 Hosheng Tu Apparatus and methods for valve removal
US7338514B2 (en) 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
DE10129525A1 (de) 2001-06-21 2003-01-09 Basf Ag Multimodale Polyamide, Polyester und Polyesteramide
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
US20030078654A1 (en) 2001-08-14 2003-04-24 Taylor Daniel C. Method and apparatus for improving mitral valve function
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
EP1432369B1 (en) 2001-08-31 2008-02-27 Mitral Interventions Apparatus for valve repair
US20030050693A1 (en) 2001-09-10 2003-03-13 Quijano Rodolfo C. Minimally invasive delivery system for annuloplasty rings
FR2829922B1 (fr) 2001-09-21 2004-06-18 Sofradim Production Implant complet et universel pour la reparation des hernies par voie anterieure
EP1434542A2 (en) 2001-10-01 2004-07-07 Ample Medical, Inc. Methods and devices for heart valve treatments
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
US7052487B2 (en) 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
US6949122B2 (en) 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US6805710B2 (en) 2001-11-13 2004-10-19 Edwards Lifesciences Corporation Mitral valve annuloplasty ring for molding left ventricle geometry
US6575971B2 (en) 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
AU2002228753A1 (en) 2001-12-04 2003-06-17 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template system
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US6978176B2 (en) 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
US6740107B2 (en) 2001-12-19 2004-05-25 Trimedyne, Inc. Device for treatment of atrioventricular valve regurgitation
US20030120341A1 (en) 2001-12-21 2003-06-26 Hani Shennib Devices and methods of repairing cardiac valves
US20030120340A1 (en) 2001-12-26 2003-06-26 Jan Liska Mitral and tricuspid valve repair
US7033390B2 (en) 2002-01-02 2006-04-25 Medtronic, Inc. Prosthetic heart valve system
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US7150750B2 (en) 2002-01-10 2006-12-19 Boston Scientific Scimed, Inc. Method and device for endoscopic suturing
WO2003105670A2 (en) 2002-01-10 2003-12-24 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7125420B2 (en) 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US20030170589A1 (en) 2002-02-27 2003-09-11 Novak Eugene J. Dental handpiece with improved grease retention
US7048754B2 (en) 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
EP1489968B1 (en) 2002-03-01 2009-02-18 Siemens Healthcare Diagnostics Inc. Assays for cancer patient monitoring based on levels of analyte components of the plasminogen activator system in body fluid samples
US7004958B2 (en) 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US7094244B2 (en) 2002-03-26 2006-08-22 Edwards Lifesciences Corporation Sequential heart valve leaflet repair device and method of use
US7588585B2 (en) 2002-03-26 2009-09-15 Novare Surgical Systems, Inc. Handleless clamping device
US7335221B2 (en) 2002-04-12 2008-02-26 Ethicon, Inc. Suture anchoring and tensioning device and method for using same
DE10217559B4 (de) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg Vorrichtung zur minimalinvasiven, intravasalen Aortenklappenextraktion
US7497822B1 (en) 2003-04-10 2009-03-03 Torax Medical, Inc. Stomach reduction methods and apparatus
AU2003247526A1 (en) 2002-06-12 2003-12-31 Mitral Interventions, Inc. Method and apparatus for tissue connection
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US8348963B2 (en) 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
EP1545371B1 (en) 2002-08-01 2016-04-13 Robert A. Levine Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
US8172856B2 (en) 2002-08-02 2012-05-08 Cedars-Sinai Medical Center Methods and apparatus for atrioventricular valve repair
CA2496007C (en) 2002-08-13 2013-02-05 The General Hospital Corporation Cardiac devices and uses thereof for percutaneous repair of atrioventricular valves
US6849062B2 (en) 2002-08-23 2005-02-01 Medtronic Vascular, Inc. Catheter having a low-friction guidewire lumen and method of manufacture
US20040092858A1 (en) 2002-08-28 2004-05-13 Heart Leaflet Technologies, Inc. Leaflet valve
ES2349952T3 (es) 2002-08-29 2011-01-13 St. Jude Medical, Cardiology Division, Inc. Dispositivos implantables para controlar la circunferencia interna de un orificio o lumen anatómico.
US7734316B2 (en) 2002-08-30 2010-06-08 Motorola, Inc. User-specified outputs in mobile wireless communication devices and methods therefor
US20040133062A1 (en) 2002-10-11 2004-07-08 Suresh Pai Minimally invasive cardiac force transfer structures
US7087064B1 (en) 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
CA2500512A1 (en) 2002-10-21 2004-05-06 Mitralign Incorporated Method and apparatus for performing catheter-based annuloplasty using local plications
US8979923B2 (en) 2002-10-21 2015-03-17 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
DE10249415B3 (de) 2002-10-23 2004-03-25 Siemens Ag System zur medizinischen Unterstützung der Insassen eines Kraftfahrzeugs
WO2004037128A1 (en) 2002-10-24 2004-05-06 Boston Scientific Limited Venous valve apparatus and method
WO2004043273A2 (en) 2002-11-13 2004-05-27 Rosengart Todd K Apparatus and method for cutting a heart valve
US20040097979A1 (en) 2002-11-14 2004-05-20 Oleg Svanidze Aortic valve implantation device
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US20070260225A1 (en) 2002-11-15 2007-11-08 Applied Medical Resources Corporation Steerable sheath actuator
US6945978B1 (en) 2002-11-15 2005-09-20 Advanced Cardiovascular Systems, Inc. Heart valve catheter
US20050256452A1 (en) 2002-11-15 2005-11-17 Demarchi Thomas Steerable vascular sheath
AU2003290979A1 (en) 2002-11-15 2004-06-15 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method and device for catheter-based repair of cardiac valves
US7037290B2 (en) 2002-12-16 2006-05-02 Medtronic, Inc. Multi-lumen steerable catheter
US20040133240A1 (en) 2003-01-07 2004-07-08 Cardiac Dimensions, Inc. Electrotherapy system, device, and method for treatment of cardiac valve dysfunction
US6928313B2 (en) 2003-01-27 2005-08-09 Cardiac Pacemakers, Inc. System and method for accessing the coronary sinus to facilitate insertion of pacing leads
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
WO2004082538A2 (en) 2003-03-18 2004-09-30 St. Jude Medical, Inc. Body tissue remodeling apparatus
US20040210240A1 (en) 2003-04-21 2004-10-21 Sean Saint Method and repair device for treating mitral valve insufficiency
US20040220593A1 (en) 2003-05-01 2004-11-04 Secant Medical, Llc Restraining clip for mitral valve repair
US20040220657A1 (en) 2003-05-02 2004-11-04 Cardiac Dimensions, Inc., A Washington Corporation Tissue shaping device with conformable anchors
US20040225233A1 (en) 2003-05-09 2004-11-11 Frankowski Brian J. Magnetic guidewires
AT500085B1 (de) * 2003-05-28 2007-01-15 Semperit Ag Holding Spleisskonstruktion für längsprofile
EP1648346A4 (en) 2003-06-20 2006-10-18 Medtronic Vascular Inc SYSTEM FOR REDUCING ANNULAR SPACE OF A PROSTHESIS VALVE
WO2004112651A2 (en) 2003-06-20 2004-12-29 Medtronic Vascular, Inc. Chordae tendinae girdle
US20050004665A1 (en) 2003-07-02 2005-01-06 Lishan Aklog Annuloplasty rings and methods for repairing cardiac valves
US8052751B2 (en) 2003-07-02 2011-11-08 Flexcor, Inc. Annuloplasty rings for repairing cardiac valves
CA2533020A1 (en) 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US7160322B2 (en) 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US7887557B2 (en) 2003-08-14 2011-02-15 Boston Scientific Scimed, Inc. Catheter having a cutting balloon including multiple cavities or multiple channels
WO2005032421A2 (en) 2003-09-15 2005-04-14 Medtronic Vascular, Inc. Apparatus and method for elongation of a papillary muscle
WO2005027797A1 (en) 2003-09-23 2005-03-31 Ersin Erek A mitral web apparatus for mitral valve insufficiencies
US8414524B2 (en) 2003-10-01 2013-04-09 Micrus Endovascular Corporation Long nose manipulatable catheter
US7004176B2 (en) 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
ES2586132T3 (es) 2003-12-23 2016-10-11 Boston Scientific Scimed, Inc. Válvula cardiaca sustituible
WO2005069850A2 (en) 2004-01-15 2005-08-04 Macoviak John A Trestle heart valve replacement
US20050159810A1 (en) 2004-01-15 2005-07-21 Farzan Filsoufi Devices and methods for repairing cardiac valves
WO2005072626A1 (en) 2004-01-23 2005-08-11 Ams Research Corporation Tissue fastening and cutting tool, and methods
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
US7641686B2 (en) 2004-04-23 2010-01-05 Direct Flow Medical, Inc. Percutaneous heart valve with stentless support
CA2563426C (en) 2004-05-05 2013-12-24 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
EP3398522B1 (en) 2004-05-14 2019-12-25 Evalve, Inc. Locking mechanisms for fixation devices
EP1750607A2 (en) 2004-06-02 2007-02-14 Medtronic, Inc. Loop ablation apparatus and method
US20050277876A1 (en) 2004-06-10 2005-12-15 Scott Hayden Medical device guiding system
US7601117B2 (en) 2004-06-30 2009-10-13 Ethicon, Inc. Systems and methods for assisting cardiac valve coaptation
US7556632B2 (en) 2004-07-09 2009-07-07 Reza Zadno Device and method for repairing tissue
US7402134B2 (en) 2004-07-15 2008-07-22 Micardia Corporation Magnetic devices and methods for reshaping heart anatomy
US8034102B2 (en) 2004-07-19 2011-10-11 Coroneo, Inc. Aortic annuloplasty ring
CA2580053C (en) 2004-09-14 2014-07-08 Edwards Lifesciences Ag. Device and method for treatment of heart valve regurgitation
US7651502B2 (en) 2004-09-24 2010-01-26 Jackson Roger P Spinal fixation tool set and method for rod reduction and fastener insertion
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
JP5124274B2 (ja) 2004-09-27 2013-01-23 エヴァルヴ インコーポレイテッド 組織の把持および評価のための方法および装置
WO2006041505A1 (en) 2004-10-02 2006-04-20 Huber Christoph Hans Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
US8613745B2 (en) 2004-10-15 2013-12-24 Baxano Surgical, Inc. Methods, systems and devices for carpal tunnel release
US7857813B2 (en) 2006-08-29 2010-12-28 Baxano, Inc. Tissue access guidewire system and method
US20060089711A1 (en) 2004-10-27 2006-04-27 Medtronic Vascular, Inc. Multifilament anchor for reducing a compass of a lumen or structure in mammalian body
US8216234B2 (en) 2004-11-10 2012-07-10 Ethicon Endo-Surgery, Inc. Tissue resection device
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
US20060184198A1 (en) 2005-01-31 2006-08-17 Kms Biopsy, Llc End effector for surgical instrument, surgical instrument, and method for forming the end effector
EP1855623B1 (en) 2005-02-07 2019-04-17 Evalve, Inc. Devices for cardiac valve repair
US20100298929A1 (en) 2005-02-07 2010-11-25 Thornton Troy L Methods, systems and devices for cardiac valve repair
WO2006113906A1 (en) 2005-04-20 2006-10-26 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US20060241746A1 (en) 2005-04-21 2006-10-26 Emanuel Shaoulian Magnetic implants and methods for reshaping tissue
US7753934B2 (en) 2005-04-22 2010-07-13 Wilk Patent, Llc Medical closure method and associated device
US20070060997A1 (en) 2005-09-15 2007-03-15 Jan De Boer Multi-lumen steerable catheter
US20070118151A1 (en) * 2005-11-21 2007-05-24 The Brigham And Women's Hospital, Inc. Percutaneous cardiac valve repair with adjustable artificial chordae
US7901454B2 (en) 2005-12-15 2011-03-08 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant valve
WO2007075892A2 (en) 2005-12-23 2007-07-05 Clinasys Llc An implantable prosthetic valve
US8715281B2 (en) 2006-03-09 2014-05-06 Olympus Medical Systems Corp. Treatment device for endoscope
AU2007254126A1 (en) 2006-05-19 2007-11-29 Conmed Endoscopic Technologies, Inc. Steerable medical instrument
WO2007149905A2 (en) 2006-06-20 2007-12-27 Aortx, Inc. Prosthetic valve implant site preparation techniques
US8012166B2 (en) 2006-07-06 2011-09-06 Centum Research Llc Laparoscopic instrument tip and method of specimen collection
EP2056750A2 (en) 2006-08-14 2009-05-13 BUCH, Wally S. Methods and apparatus for mitral valve repair
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8840625B2 (en) 2006-10-18 2014-09-23 Hologic, Inc. Systems for performing gynecological procedures with closed visualization lumen
WO2008064111A2 (en) 2006-11-17 2008-05-29 Boston Scientific Limited Radiopaque medical devices
US8657815B2 (en) 2007-02-06 2014-02-25 Microcube, Llc Delivery system for delivering a medical device to a location within a patient's body
EP2114304B1 (en) 2007-02-14 2017-09-06 Edwards Lifesciences Corporation implantable medical device for repairing heart
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US7533790B1 (en) 2007-03-08 2009-05-19 Cardica, Inc. Surgical stapler
US20080255624A1 (en) 2007-03-30 2008-10-16 Gregory Arcenio Methods and devices for multipoint access of a body part
US20080294175A1 (en) 2007-05-21 2008-11-27 Epitek, Inc. Left atrial appendage closure
US9211119B2 (en) 2007-07-03 2015-12-15 Ceterix Orthopaedics, Inc. Suture passers and methods of passing suture
US20090012538A1 (en) 2007-07-03 2009-01-08 Justin Saliman Methods and devices for continuous suture passing
WO2009061504A1 (en) 2007-11-05 2009-05-14 Revolutionary Surgical Device, Llc Suture passing instrument and method
US20090204005A1 (en) 2008-02-07 2009-08-13 Broncus Technologies, Inc. Puncture resistant catheter for sensing vessels and for creating passages in tissue
US8398673B2 (en) 2008-02-15 2013-03-19 Surgical Innovations V.O.F. Surgical instrument for grasping and cutting tissue
US8968393B2 (en) * 2008-02-28 2015-03-03 Medtronic, Inc. System and method for percutaneous mitral valve repair
US20100121437A1 (en) 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US7954688B2 (en) 2008-08-22 2011-06-07 Medtronic, Inc. Endovascular stapling apparatus and methods of use
JP5611948B2 (ja) 2008-08-25 2014-10-22 カーディオキネティックス・インコーポレイテッドＣａｒｄｉｏｋｉｎｅｔｉｘ， Ｉｎｃ． 回収可能心臓用装置
WO2010096347A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
WO2010118064A1 (en) 2009-04-06 2010-10-14 O'donnell Michael J System and method for resecting a valve
JP2012523894A (ja) 2009-04-15 2012-10-11 カルディアック バルブ テクノロジーズ，インコーポレーテッド 血管インプラント及びその配設システム
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
DE102009020897A1 (de) 2009-05-08 2010-11-11 Aesculap Ag Faden mit beschichteten Verankerungsstrukturen zur Verankerung in biologischen Geweben und ein Verfahren zu seiner Herstellung
US8246618B2 (en) 2009-07-08 2012-08-21 Tyco Healthcare Group Lp Electrosurgical jaws with offset knife
WO2011033508A1 (en) 2009-09-15 2011-03-24 Transcardia Ltd. Heart valve remodeling
US20120265222A1 (en) 2009-10-01 2012-10-18 Virtual Ports Ltd. System and method for forming a knot
BR112012016311A2 (pt) 2009-12-30 2017-03-28 Ams Res Corp ferramenta multifuncional utilizável em um procedimento para instalar um implante pélvico
US8480671B2 (en) 2010-01-22 2013-07-09 Covidien Lp Compact jaw including split pivot pin
US9414914B2 (en) * 2010-02-24 2016-08-16 Medtronic Ventor Technologies Ltd. Catheter assembly with valve crimping accessories
EP4129238A1 (en) 2010-03-05 2023-02-08 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9023032B2 (en) 2010-03-25 2015-05-05 Covidien Lp Shaped circuit boards suitable for use in electrosurgical devices and rotatable assemblies including same
EP2558007A4 (en) 2010-04-13 2017-11-29 Sentreheart, Inc. Methods and devices for accessing and delivering devices to a heart
WO2011143359A2 (en) 2010-05-11 2011-11-17 Cardiac Inventions Unlimited Apparatus for safe performance of transseptal technique and placement and positioning of an ablation catheter
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9192431B2 (en) 2010-07-23 2015-11-24 Ethicon Endo-Surgery, Inc. Electrosurgical cutting and sealing instrument
JP5508190B2 (ja) 2010-08-10 2014-05-28 日本ライフライン株式会社 カテーテル
US10076327B2 (en) 2010-09-14 2018-09-18 Evalve, Inc. Flexible actuator mandrel for tissue apposition systems
WO2012092377A1 (en) 2010-12-30 2012-07-05 Claret Medical, Inc. Intravascular blood filters and methods of use
BR112013019560A2 (pt) * 2011-02-01 2018-07-17 St Jude Medical método e dispositivo para o recolhimento de transcateter de tecido de um folíolo de válvula cardíaca.
US10111663B2 (en) 2011-02-18 2018-10-30 Ancora Heart, Inc. Implant retrieval device
CN106943216B (zh) 2011-04-06 2019-12-31 德普伊新特斯产品有限责任公司 植入修正髋关节假体的器械组件
AU2012261998B2 (en) * 2011-06-01 2017-03-02 Neochord, Inc. Minimally invasive repair of heart valve leaflets
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US8641777B2 (en) 2011-06-03 2014-02-04 Reverse Medical Corporation Embolic implant and method of use
US9101471B2 (en) 2011-06-13 2015-08-11 Edwards Lifesciences Corporation Systems and delivery handles for delivering prosthetic heart valves disposed on valve holders
US8926588B2 (en) 2011-07-05 2015-01-06 Medtronic Vascular, Inc. Steerable delivery catheter
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US20130041314A1 (en) 2011-08-11 2013-02-14 Cook Medical Technologies Llc Steerable Catheters
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US10624664B2 (en) 2011-09-28 2020-04-21 Evalve, Inc. Apparatuses and methods for cutting a tissue bridge and/or removing a heart valve clip or suture
US9445893B2 (en) 2011-11-21 2016-09-20 Mor Research Applications Ltd. Device for placement in the tricuspid annulus
FR2985019B1 (fr) 2011-12-21 2014-01-24 Irsn Fluxmetre auto-etalonne
US20140364866A1 (en) 2012-01-06 2014-12-11 University Of Louisville Research Foundation, Inc. Endoscopic snare device
AU2013213888B2 (en) 2012-01-31 2017-08-10 Mitral Valve Technologies Sarl Mitral valve docking devices, systems and methods
GB2500432A (en) 2012-03-22 2013-09-25 Stephen Brecker Replacement heart valve with resiliently deformable securing means
US20160008007A1 (en) 2012-07-17 2016-01-14 Truminim, LLC Percutaneous system and methods for enhanced epidural access for spine surgery
US9254141B2 (en) 2012-08-02 2016-02-09 St. Jude Medical, Inc. Apparatus and method for heart valve repair
US9649212B2 (en) 2012-08-30 2017-05-16 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter comprising a release device
EP3517052A1 (en) 2012-10-23 2019-07-31 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
JP6280932B2 (ja) 2013-02-04 2018-02-14 トゥエルヴ， インコーポレイテッド 人工心臓弁デバイスのための液圧送達システムおよび関連方法
EP3636177B1 (en) 2013-03-11 2023-07-19 Mayo Foundation for Medical Education and Research Pericardial modification systems for heart failure treatment
US9855066B2 (en) 2013-03-12 2018-01-02 Boston Scientific Scimed, Inc. Retrieval device and related methods of use
US9999425B2 (en) * 2013-03-13 2018-06-19 St. Jude Medical, Cardiology Division, Inc. Mitral valve leaflet clip
US9364238B2 (en) 2013-04-16 2016-06-14 Ethicon Endo-Surgery, Inc. Method and apparatus for joining hollow organ sections in anastomosis
EP2956197B1 (en) 2013-05-07 2017-02-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Steerable medical device having multiple curve profiles
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
US20150005801A1 (en) 2013-06-27 2015-01-01 Covidien Lp Microcatheter system
CN105451686B (zh) 2013-08-14 2018-03-20 索林集团意大利有限责任公司 用于腱索置换的装置和方法
US9248018B2 (en) 2013-09-27 2016-02-02 Surendra K. Chawla Valve repair device
US9925045B2 (en) 2013-10-21 2018-03-27 Medtronic Vascular Galway Systems, devices and methods for transcatheter valve delivery
JP6554094B2 (ja) * 2013-10-28 2019-07-31 テンダイン ホールディングス，インコーポレイテッド 人工心臓弁及び人工心臓弁を送達するシステム及び方法
US10022218B2 (en) 2014-02-14 2018-07-17 Cook Medical Technologies Llc Tricuspid regurgitation model and methods of evaluating intraluminal medical devices
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9505159B2 (en) 2014-04-25 2016-11-29 Medtronic Ablation Frontiers Llc Methods of dimensionally stabilizing a lumen of a multi-lumen device during manufacture
US20170232238A1 (en) 2014-08-06 2017-08-17 Edwars Litesciences Corporation Multi-lumen cannulae
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US10390950B2 (en) 2014-10-03 2019-08-27 St. Jude Medical, Cardiology Division, Inc. Flexible catheters and methods of forming same
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
EP4353203A3 (en) 2015-03-20 2024-07-03 JenaValve Technology, Inc. Heart valve prosthesis delivery system
CA2995603C (en) 2015-08-14 2023-10-31 Caisson Interventional Llc Systems and methods for heart valve therapy
US11963712B2 (en) 2016-06-20 2024-04-23 Evalve, Inc. Transapical removal device
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955340B2 (en) * 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8257356B2 (en) * 2004-10-15 2012-09-04 Baxano, Inc. Guidewire exchange systems to treat spinal stenosis
US9126032B2 (en) * 2010-12-13 2015-09-08 Pacesetter, Inc. Pacemaker retrieval systems and methods
US20140228871A1 (en) * 2011-09-28 2014-08-14 Mitracore Technologies Inc. Apparatuses and methods for cutting a tissue bridge and/or removing a heart valve clip or suture
CN104244841A (zh) * 2012-03-06 2014-12-24 海莱夫简易股份公司 具备环绕功能的医疗导管件
US20150257883A1 (en) * 2014-03-17 2015-09-17 Evalve, Inc. Mitral valve fixation device removal devices and methods

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113993572A (zh) * 2019-07-25 2022-01-28 创新心有限公司 用于在心脏瓣膜周围布置导丝的装置
US12076233B2 (en) 2019-07-25 2024-09-03 Innovheart S.R.L. Device for implanting a prosthesis for a heart valve and assembly procedure
CN114642480A (zh) * 2020-12-18 2022-06-21 应脉医疗科技(上海)有限公司 一种瓣膜夹子切除装置
CN113230000A (zh) * 2021-05-27 2021-08-10 应脉医疗科技(上海)有限公司 一种瓣膜夹子移除系统
WO2022247682A1 (zh) * 2021-05-27 2022-12-01 应脉医疗科技(上海)有限公司 一种瓣膜夹子移除系统
CN114081674A (zh) * 2021-09-28 2022-02-25 四川大学华西医院 一种瓣叶分割装置
CN114081674B (zh) * 2021-09-28 2023-08-15 四川大学华西医院 一种瓣叶分割装置

Also Published As

Publication number Publication date
SG11201811457QA (en) 2019-01-30
EP3791795B1 (en) 2022-03-02
US20200323528A1 (en) 2020-10-15
WO2018009718A1 (en) 2018-01-11
EP3481303A1 (en) 2019-05-15
JP2022088522A (ja) 2022-06-14
JP7346645B2 (ja) 2023-09-19
CN113842188A (zh) 2021-12-28
EP3791795A1 (en) 2021-03-17
CR20190042A (es) 2019-07-08
CN109561891B (zh) 2021-09-28
EP3481303B1 (en) 2020-12-23
US10736632B2 (en) 2020-08-11
CN113842188B (zh) 2023-12-05
JP2023166503A (ja) 2023-11-21
US20180008268A1 (en) 2018-01-11
EP3481303A4 (en) 2019-12-18
JP2019520917A (ja) 2019-07-25

Similar Documents

Publication Publication Date Title
CN109561891A (zh) 用于瓣膜夹子切除的方法和装置
US11730598B2 (en) Prosthetic device for heart valve
US11832829B2 (en) Stabilization of a transseptal delivery device
EP3870088B1 (en) Tissue cutting systems and devices
US11980545B2 (en) Annuloplasty procedures, related devices and methods
JP2022110075A (ja) インプラント
US11950827B2 (en) Tissue excision, cutting, and removal systems and methods
CN112654332A (zh) 用于瓣膜关闭不全的经导管人工瓣尖
KR20150091337A (ko) 인공 보철 심장 판막을 이식하기 위해 심방실 내에 가이드 와이어들의 시스템을 전개하는 전개 장치
JP2022541414A (ja) 心臓弁治療の除去方法及び装置
US20210346029A1 (en) Clip removal systems and methods
US20220287840A1 (en) A medical arrangement for introducing an object into an anatomical target position
US20220273435A1 (en) A medical arrangement for introducing an object into an anatomical target position
US20230346543A1 (en) Devices, systems, and methods for controlling deployment of a medical device
AU2023239164A1 (en) Clips implanted in the heart and great vessels that allow their complete or partial removal, kits and methods to perform such removal

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant