CN109152827B - 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途 - Google Patents
重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途 Download PDFInfo
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- CN109152827B CN109152827B CN201780025762.9A CN201780025762A CN109152827B CN 109152827 B CN109152827 B CN 109152827B CN 201780025762 A CN201780025762 A CN 201780025762A CN 109152827 B CN109152827 B CN 109152827B
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- mvaδe3l
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662300066P | 2016-02-25 | 2016-02-25 | |
| US62/300,066 | 2016-02-25 | ||
| US201662418786P | 2016-11-07 | 2016-11-07 | |
| US62/418,786 | 2016-11-07 | ||
| US201662418788P | 2016-11-08 | 2016-11-08 | |
| US62/418,788 | 2016-11-08 | ||
| PCT/US2017/019549 WO2017147554A2 (en) | 2016-02-25 | 2017-02-25 | Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109152827A CN109152827A (zh) | 2019-01-04 |
| CN109152827B true CN109152827B (zh) | 2023-07-21 |
Family
ID=59685692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780025762.9A Expired - Fee Related CN109152827B (zh) | 2016-02-25 | 2017-02-25 | 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10736962B2 (https=) |
| EP (1) | EP3419662A4 (https=) |
| JP (2) | JP7034080B2 (https=) |
| KR (1) | KR20180130500A (https=) |
| CN (1) | CN109152827B (https=) |
| AU (2) | AU2017222687B2 (https=) |
| BR (1) | BR112018016948A2 (https=) |
| CA (1) | CA3015818A1 (https=) |
| IL (2) | IL261321B2 (https=) |
| MX (2) | MX2018010231A (https=) |
| SG (1) | SG11201807022XA (https=) |
| WO (1) | WO2017147554A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4122492A1 (en) | 2015-02-25 | 2023-01-25 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| KR20180006916A (ko) * | 2015-04-17 | 2018-01-19 | 메모리얼 슬로안-케터링 캔서 센터 | 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도 |
| JP7025339B2 (ja) | 2016-02-25 | 2022-02-24 | メモリアル スローン ケタリング キャンサー センター | 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトflt3lまたはgm-csfの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス |
| CN109152827B (zh) | 2016-02-25 | 2023-07-21 | 纪念斯隆凯特琳癌症中心 | 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途 |
| US10888594B2 (en) | 2016-05-30 | 2021-01-12 | National University Corporation Tottori University | Genetically engineered vaccinia viruses |
| US20190336552A1 (en) | 2016-05-30 | 2019-11-07 | Astellas Pharma Inc. | Genetically engineered vaccinia viruses |
| EP3621646A4 (en) | 2017-05-12 | 2021-06-02 | Memorial Sloan Kettering Cancer Center | VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY |
| WO2019090343A1 (en) * | 2017-11-06 | 2019-05-09 | Memorial Sloan Kettering Cancer Center | Heat-inactivated vaccinia virus as a vaccine immune adjuvant |
| AU2019234642A1 (en) * | 2018-03-13 | 2020-09-24 | Memorial Sloan Kettering Cancer Center | Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy |
| BR112021004692A2 (pt) * | 2018-09-15 | 2021-06-08 | Memorial Sloan Kettering Cancer Center | poxvírus recombinantes para imunoterapia de câncer |
| US11638730B2 (en) * | 2018-09-26 | 2023-05-02 | Astellas Pharma Inc. | Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy |
| MX2021005560A (es) | 2018-11-20 | 2021-06-23 | Bavarian Nordic As | Terapia para el tratamiento del cancer con administracion intratumoral y/o intravenosa de un virus vaccinia ankara (mva) recombinante que codifica ligando 4-1bbl (cd137l) y/o ligando del cumulo o grupo de diferenciacion 40 (cd40l). |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| KR20220115569A (ko) | 2019-11-18 | 2022-08-17 | 얀센 바이오테크 인코포레이티드 | 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도 |
| CN114929268A (zh) * | 2019-11-20 | 2022-08-19 | 巴法里安诺迪克有限公司 | 4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途 |
| AU2021239667A1 (en) * | 2020-03-19 | 2022-09-08 | Chugai Seiyaku Kabushiki Kaisha | Biomarkers for predicting the response to checkpoint inhibitors |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022052982A1 (zh) * | 2020-09-14 | 2022-03-17 | 昭明泽康(北京)生物医药科技有限公司 | PPARα(过氧化物酶体增殖物激活受体α)配体在制备药物中的应用 |
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| CN105744950A (zh) * | 2013-11-05 | 2016-07-06 | 巴法里安诺迪克有限公司 | 用于使用表达肿瘤抗原的痘病毒和免疫检查点抑制剂的拮抗剂和/或激动剂治疗癌症的组合疗法 |
| WO2016168862A1 (en) * | 2015-04-17 | 2016-10-20 | Memorial Sloan-Kettering Cancer Center | Use of mva or mvadeltae3l as immunotherapeutic agents against solid tumors |
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| AU2022203309A1 (en) | 2022-06-30 |
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| EP3419662A4 (en) | 2019-09-18 |
| US20190046640A1 (en) | 2019-02-14 |
| IL261321B1 (en) | 2023-08-01 |
| US12036279B2 (en) | 2024-07-16 |
| SG11201807022XA (en) | 2018-09-27 |
| KR20180130500A (ko) | 2018-12-07 |
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| JP7034080B2 (ja) | 2022-03-11 |
| US11285209B2 (en) | 2022-03-29 |
| BR112018016948A2 (pt) | 2019-01-08 |
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