CN1090627C - 2－氨基－1,2－二氢化茚化合物其制备方法和药物组合物 - Google Patents

2－氨基－1,2－二氢化茚化合物其制备方法和药物组合物 Download PDF

Info

Publication number
CN1090627C
CN1090627C CN98107709A CN98107709A CN1090627C CN 1090627 C CN1090627 C CN 1090627C CN 98107709 A CN98107709 A CN 98107709A CN 98107709 A CN98107709 A CN 98107709A CN 1090627 C CN1090627 C CN 1090627C
Authority
CN
China
Prior art keywords
piperidine
indan
amino
compound
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN98107709A
Other languages
English (en)
Chinese (zh)
Other versions
CN1194983A (zh
Inventor
J·L·派格里昂
B·古门特
M·米兰
A·格伯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of CN1194983A publication Critical patent/CN1194983A/zh
Application granted granted Critical
Publication of CN1090627C publication Critical patent/CN1090627C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN98107709A 1997-02-27 1998-02-26 2－氨基－1,2－二氢化茚化合物其制备方法和药物组合物 Expired - Fee Related CN1090627C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9702360 1997-02-27
FR9702360A FR2760014B1 (fr) 1997-02-27 1997-02-27 Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CN1194983A CN1194983A (zh) 1998-10-07
CN1090627C true CN1090627C (zh) 2002-09-11

Family

ID=9504253

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98107709A Expired - Fee Related CN1090627C (zh) 1997-02-27 1998-02-26 2－氨基－1,2－二氢化茚化合物其制备方法和药物组合物

Country Status (18)

Country Link
US (1) US5968954A (https=)
EP (1) EP0861837B1 (https=)
JP (1) JPH10237071A (https=)
CN (1) CN1090627C (https=)
AT (1) ATE265451T1 (https=)
AU (1) AU725756B2 (https=)
BR (1) BR9800763A (https=)
CA (1) CA2231025C (https=)
DE (1) DE69823411T2 (https=)
DK (1) DK0861837T3 (https=)
ES (1) ES2219853T3 (https=)
FR (1) FR2760014B1 (https=)
HU (1) HU224312B1 (https=)
NO (1) NO314307B1 (https=)
NZ (1) NZ329853A (https=)
PL (1) PL190240B1 (https=)
PT (1) PT861837E (https=)
ZA (1) ZA981680B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI274750B (en) 1999-01-12 2007-03-01 Abbott Gmbh & Co Kg Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
SE0103650D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic heterocyclic compounds
NZ535574A (en) * 2001-01-16 2006-07-28 Astrazeneca Ab Therapeutic heterocyclic compounds
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
JP2005343790A (ja) * 2002-05-31 2005-12-15 Ajinomoto Co Inc カルシウムチャネル拮抗薬を含有する医薬組成物
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
CA2587749A1 (en) * 2004-12-08 2006-06-15 Astellas Pharma Inc. Piperidine derivative and process for producing the same
UY29892A1 (es) * 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007274A1 (en) * 1993-09-06 1995-03-16 Knoll Ag Bicyclic aromatic compounds as therapeutic agents
EP0745598A1 (fr) * 1995-05-31 1996-12-04 Adir Et Compagnie Nouveaux composés de la pipérazine, de la pipéridine et de la 1,2,5,6-tétra-hydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007274A1 (en) * 1993-09-06 1995-03-16 Knoll Ag Bicyclic aromatic compounds as therapeutic agents
EP0745598A1 (fr) * 1995-05-31 1996-12-04 Adir Et Compagnie Nouveaux composés de la pipérazine, de la pipéridine et de la 1,2,5,6-tétra-hydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
PT861837E (pt) 2004-07-30
FR2760014A1 (fr) 1998-08-28
BR9800763A (pt) 1999-12-07
CN1194983A (zh) 1998-10-07
NO980803L (no) 1998-08-28
NO980803D0 (no) 1998-02-26
CA2231025C (fr) 2003-09-16
DK0861837T3 (da) 2004-08-16
HU224312B1 (hu) 2005-07-28
FR2760014B1 (fr) 1999-04-09
EP0861837B1 (fr) 2004-04-28
PL324982A1 (en) 1998-08-31
HUP9800422A1 (hu) 1999-12-28
DE69823411T2 (de) 2005-02-17
DE69823411D1 (de) 2004-06-03
US5968954A (en) 1999-10-19
ES2219853T3 (es) 2004-12-01
HU9800422D0 (en) 1998-04-28
PL190240B1 (pl) 2005-11-30
JPH10237071A (ja) 1998-09-08
NZ329853A (en) 1999-01-28
CA2231025A1 (fr) 1998-08-27
HK1014945A1 (en) 1999-10-08
EP0861837A1 (fr) 1998-09-02
NO314307B1 (no) 2003-03-03
AU725756B2 (en) 2000-10-19
ATE265451T1 (de) 2004-05-15
ZA981680B (en) 1998-09-04
AU5635998A (en) 1998-09-03

Similar Documents

Publication Publication Date Title
CN1090628C (zh) 新的n－芳基哌啶化合物,其制备方法和含有它们的药物组合物
JP3203230B2 (ja) 抗不安作用を有するピペリジン誘導体
CN1034865C (zh) 2-氨基嘧啶酮的制备方法
CA2297825C (en) Indole and 2,3-dihydroindole derivatives, their preparation and use
CN102482251B (zh) 色酮衍生物、其制备方法及其治疗应用
ES2280417T3 (es) Derivados de benzoxazinona, su preparacion y uso.
CN1344265A (zh) 哌啶、四氢吡啶和哌嗪衍生物,它们的制备和用途
JP2005513016A (ja) スルホンアミド誘導体類と、その製造方法及び医薬としての応用
CN1090627C (zh) 2－氨基－1,2－二氢化茚化合物其制备方法和药物组合物
CN1437597A (zh) 取代的苯基－哌嗪衍生物及其制备和用途
CN1805956A (zh) 苯并咪唑衍生物、含有它们的组合物、它们的制备以及它们的用途
CN1177847C (zh) 作为5－ht2a拮抗剂的噁唑烷酮类化合物
KR20130091791A (ko) Ｍ１ 수용체에서 활성을 갖는 화합물 및 그의 의약적 용도
CN1152874C (zh) 抗精神病的4-(1h-吲哚基-1-基)-1-取代哌啶衍生物
WO2002006231A1 (en) Serotonin reuptake inhibitors
WO2006051826A1 (ja) 含窒素複素環化合物およびその医薬用途
CN1128144C (zh) 新的茚满－1－醇化合物，其制备方法及含有它们的药物组合物
JP6943239B2 (ja) Ｋｃｎｑ２〜５チャネル活性化剤
CN1304409A (zh) 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂)
JP2001508419A (ja) ５−ｈｔ受容体活性を有するスルホンアミド化合物
BRPI0613430A2 (pt) compostos derivados de benzimidazol, uso dos mesmos, método para a preparação destes e composição farmacêutica
HK1014945B (en) 2-aminoindan compounds, a process for their preparation and pharmaceutical compositions containing them
JP2002534427A (ja) ３，４−ジヒドロ−２ｈ−ベンゾ［１，４］オキサジニル−メチル［３−（１ｈ−インドール−３−イル）−アルキル］−アミン
CN1439004A (zh) 用于治疗中枢神经系统疾病的吲哚衍生物
CN1127501C (zh) 吲哚和2,3－二氢吲哚衍生物、它们的制备及用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee