CN1089469A - 用于持续释放药物的传送装置的二相基材 - Google Patents

用于持续释放药物的传送装置的二相基材 Download PDF

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Publication number
CN1089469A
CN1089469A CN93118244A CN93118244A CN1089469A CN 1089469 A CN1089469 A CN 1089469A CN 93118244 A CN93118244 A CN 93118244A CN 93118244 A CN93118244 A CN 93118244A CN 1089469 A CN1089469 A CN 1089469A
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drug
sustained
substrate
phase
release
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CN93118244A
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English (en)
Chinese (zh)
Inventor
许宗民
陈栋奋
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Cygnus Therapeutic Systems
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Cygnus Therapeutic Systems
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Publication of CN1089469A publication Critical patent/CN1089469A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN93118244A 1992-10-05 1993-10-05 用于持续释放药物的传送装置的二相基材 Pending CN1089469A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95663592A 1992-10-05 1992-10-05
US956,635 1992-10-05
US08/056,076 US5989586A (en) 1992-10-05 1993-04-30 Two-phase matrix for sustained release drug delivery device
US056,076 1993-04-30

Publications (1)

Publication Number Publication Date
CN1089469A true CN1089469A (zh) 1994-07-20

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Family Applications (1)

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CN93118244A Pending CN1089469A (zh) 1992-10-05 1993-10-05 用于持续释放药物的传送装置的二相基材

Country Status (14)

Country Link
US (2) US5989586A (https=)
EP (1) EP0662822B1 (https=)
JP (1) JPH08504757A (https=)
CN (1) CN1089469A (https=)
AT (1) ATE198420T1 (https=)
AU (1) AU5321194A (https=)
CA (1) CA2145631C (https=)
DE (1) DE69329825T2 (https=)
DK (1) DK0662822T3 (https=)
ES (1) ES2155073T3 (https=)
GR (1) GR3035626T3 (https=)
PT (1) PT662822E (https=)
TW (1) TW252919B (https=)
WO (1) WO1994007468A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100457095C (zh) * 2001-05-08 2009-02-04 施瓦茨制药有限公司 用于治疗帕金森氏病的改良经皮治疗系统
CN100558350C (zh) * 2002-07-30 2009-11-11 施瓦茨制药有限公司 改良透皮递药系统
CN102172351B (zh) * 2001-05-08 2013-07-17 优时比制药有限公司 引起高罗替高汀血浆水平的用于治疗帕金森氏病的透皮治疗系统

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CN100558350C (zh) * 2002-07-30 2009-11-11 施瓦茨制药有限公司 改良透皮递药系统

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ATE198420T1 (de) 2001-01-15
WO1994007468A1 (en) 1994-04-14
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US5989586A (en) 1999-11-23
GR3035626T3 (en) 2001-06-29
JPH08504757A (ja) 1996-05-21
PT662822E (pt) 2001-04-30
US5840336A (en) 1998-11-24
EP0662822A1 (en) 1995-07-19
EP0662822A4 (en) 1996-08-07
EP0662822B1 (en) 2001-01-03
TW252919B (https=) 1995-08-01
CA2145631A1 (en) 1994-04-14
AU5321194A (en) 1994-04-26

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