DE69329825D1 - Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung - Google Patents
Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzungInfo
- Publication number
- DE69329825D1 DE69329825D1 DE69329825T DE69329825T DE69329825D1 DE 69329825 D1 DE69329825 D1 DE 69329825D1 DE 69329825 T DE69329825 T DE 69329825T DE 69329825 T DE69329825 T DE 69329825T DE 69329825 D1 DE69329825 D1 DE 69329825D1
- Authority
- DE
- Germany
- Prior art keywords
- phase
- delivery system
- delayed release
- medicinal products
- phase matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95663592A | 1992-10-05 | 1992-10-05 | |
US08/056,076 US5989586A (en) | 1992-10-05 | 1993-04-30 | Two-phase matrix for sustained release drug delivery device |
PCT/US1993/009510 WO1994007468A1 (en) | 1992-10-05 | 1993-10-05 | Two-phase matrix for sustained release drug delivery device |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69329825D1 true DE69329825D1 (de) | 2001-02-08 |
DE69329825T2 DE69329825T2 (de) | 2001-06-13 |
Family
ID=26734946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329825T Expired - Lifetime DE69329825T2 (de) | 1992-10-05 | 1993-10-05 | Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung |
Country Status (14)
Country | Link |
---|---|
US (2) | US5989586A (de) |
EP (1) | EP0662822B1 (de) |
JP (1) | JPH08504757A (de) |
CN (1) | CN1089469A (de) |
AT (1) | ATE198420T1 (de) |
AU (1) | AU5321194A (de) |
CA (1) | CA2145631C (de) |
DE (1) | DE69329825T2 (de) |
DK (1) | DK0662822T3 (de) |
ES (1) | ES2155073T3 (de) |
GR (1) | GR3035626T3 (de) |
PT (1) | PT662822E (de) |
TW (1) | TW252919B (de) |
WO (1) | WO1994007468A1 (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
US5383873A (en) * | 1992-12-09 | 1995-01-24 | Regents Of The University Of Minnesota | Smooth muscle chemical pacemaker |
WO1996022084A2 (en) * | 1995-01-19 | 1996-07-25 | Cygnus, Inc. | Polymer adhesive formulation containing sorbent particles |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
JP4154621B2 (ja) * | 1996-02-07 | 2008-09-24 | リードケミカル株式会社 | トラニラスト含有外用製剤及びその製造方法 |
JPH10167956A (ja) * | 1996-12-11 | 1998-06-23 | Hisamitsu Pharmaceut Co Inc | セロトニン受容体拮抗薬含有経皮投与製剤 |
US6119036A (en) * | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
AU3170697A (en) * | 1997-05-30 | 1998-12-30 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery device for the delivery of tropisetron or granisetron |
AU3311599A (en) * | 1998-02-25 | 1999-09-15 | Iomai Corporation | Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by adp-ribosylating exotoxin |
DE19814087A1 (de) * | 1998-03-30 | 1999-10-14 | Lohmann Therapie Syst Lts | Feuchtigkeitsaktivierbares therapeutisches System |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
EP2368575B1 (de) * | 1999-04-08 | 2014-10-01 | Intercell USA, Inc. | Trockenformulierung für transkutane immunisierung |
DE19929197A1 (de) * | 1999-06-25 | 2000-12-28 | Novosis Pharma Ag | Transdermalsysteme zur Abgabe von 5-HT3-Rezeptor-Antagonisten und ihre Verwendung zur antiemitischen Behandlung |
US20040109874A1 (en) * | 1999-11-10 | 2004-06-10 | Powderject Vaccines, Inc. | Induction of mucosal immunity by vaccination via the skin route |
US6558695B2 (en) * | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
US6562370B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
US6586000B2 (en) | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
US20030104041A1 (en) * | 1999-12-16 | 2003-06-05 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
US6602912B2 (en) | 2000-06-30 | 2003-08-05 | Dermatrends, Inc. | Transdermal administration of phenylpropanolamine |
US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
US6562368B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
US6719997B2 (en) | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
US6565879B1 (en) | 1999-12-16 | 2003-05-20 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers |
US6562369B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers |
US6645520B2 (en) * | 1999-12-16 | 2003-11-11 | Dermatrends, Inc. | Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers |
US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
KR100393478B1 (ko) * | 2000-03-29 | 2003-08-06 | 주식회사종근당 | 자가유화 매트릭스형 경점막·경피흡수제제 |
DE10015783C2 (de) * | 2000-03-30 | 2003-12-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung |
US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
DE10027258C1 (de) * | 2000-05-31 | 2001-10-31 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit okklusiver wirkstoffhaltiger Schicht und nicht-okklusiver Rückschicht |
DE10041479A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
ATE319428T1 (de) | 2000-12-07 | 2006-03-15 | Univ Utrecht Holding Bv | Zusammensetzung zur behandlung von entzündlichen erkrankungen |
EP1256339B1 (de) * | 2001-05-08 | 2003-10-15 | Schwarz Pharma Ag | Transdermales therapeutisches System für die Erzielung hoher Plasmaspiegel von Rotigotin in der Therapie von Morbus Parkinson |
PT1256340E (pt) * | 2001-05-08 | 2003-12-31 | Sanol Arznei Schwarz Gmbh | Sistema terapeutico transdermico aperfeicoado para o tratamento da doenca de parkinson |
DE10136784A1 (de) | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut |
RU2302233C2 (ru) * | 2001-09-10 | 2007-07-10 | Ф.Хоффманн-Ля Рош Аг | Масляные тиксотропные композиции |
US7273619B2 (en) * | 2002-01-17 | 2007-09-25 | Samyang Corporation | Transdermal composition of an antivomiting agent |
US20060263419A1 (en) * | 2002-03-12 | 2006-11-23 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
EP1517709B1 (de) * | 2002-06-20 | 2008-06-11 | Amnon Sintov | Transdermales arzneimittelverabreichungssystem |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
EP1386605A1 (de) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Verbessertes transdermales System für die Verabreichung von Rotigotin |
EP1386604A1 (de) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Verbessertes transdermales Verabreichungssystem |
DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8246980B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
IL152575A (en) * | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
IL152573A (en) * | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
PT1426049E (pt) * | 2002-12-02 | 2005-09-30 | Sanol Arznei Schwarz Gmbh | Administracao iontoforetica de rotigotina para o tratamento da doenca de parkinson |
DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
US20050019366A1 (en) * | 2002-12-31 | 2005-01-27 | Zeldis Jerome B. | Drug-coated stents and methods of use therefor |
GB0302662D0 (en) | 2003-02-05 | 2003-03-12 | Strakan Ltd | Transdermal granisetron |
DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
US20050118246A1 (en) * | 2003-10-31 | 2005-06-02 | Wong Patrick S. | Dosage forms and layered deposition processes for fabricating dosage forms |
EP1547592A1 (de) | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasale formulierung enthaltend |
US7262145B2 (en) * | 2004-04-23 | 2007-08-28 | Kennametal Inc. | Whisker-reinforced ceramic containing aluminum oxynitride and method of making the same |
JP2008511663A (ja) * | 2004-09-01 | 2008-04-17 | ネクスメツド・ホールデイングス・インコーポレイテツド | 経皮制吐送達系、そのための方法および組成物 |
SE528360C2 (sv) * | 2004-09-10 | 2006-10-24 | Doxa Ab | Resorberbara keramiska kompositioner avsedda för medicinska implantat |
WO2006039532A2 (en) * | 2004-09-29 | 2006-04-13 | Schwarz Pharma, Inc. | Transdermal therapeutic system for parkinson’s disease |
US20060263421A1 (en) | 2005-05-18 | 2006-11-23 | Abeille Pharmaceuticals Inc | Transdermal Method and Patch for Nausea |
KR101207553B1 (ko) | 2005-06-02 | 2012-12-03 | (주)씨앤팜 | 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체 |
KR20080080087A (ko) * | 2005-09-30 | 2008-09-02 | 티티아이 엘뷰 가부시키가이샤 | 신규 약학 담체를 이용한 경피 약물 전달시스템, 장치 및방법 |
JP5005916B2 (ja) * | 2005-12-09 | 2012-08-22 | スリーエム イノベイティブ プロパティズ カンパニー | 皮膚粘着剤用剥離剤組成物 |
KR101402592B1 (ko) * | 2006-03-06 | 2014-06-17 | 에스케이바이오팜 주식회사 | 피록시캄-무기물 복합체를 포함하는 경피투여 조성물 및이를 이용한 패치시스템 |
WO2009086840A1 (en) | 2008-01-10 | 2009-07-16 | Coloplast A/S | A pressure sensitive adhesive composition comprising a water soluble compound |
JP5547065B2 (ja) | 2008-05-15 | 2014-07-09 | 久光製薬株式会社 | パロノセトロンを含有する経皮吸収製剤 |
DE102008060203A1 (de) | 2008-12-07 | 2010-06-10 | Dietrich Wilhelm Schacht | Wirkstoffstabilisierende flächenförmige Vorrichtung |
CN102292076A (zh) * | 2008-12-11 | 2011-12-21 | 阿帕医药有限公司 | 增强聚原酸酯及其制剂的稳定性的方法 |
EP2281559A1 (de) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmazeutische Zusammensetzung enthaltend Rotigotin (Salze oder Na), insbesondere für Iontophorese |
EP2515887B1 (de) | 2009-12-22 | 2018-06-06 | UCB Biopharma SPRL | Polyvinylpyrrolidon zur stabilisierung einer feststoffdispersion der nichtkristallinen form von rotigotin |
US8563031B2 (en) | 2010-05-27 | 2013-10-22 | Absize, Inc. | Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith |
CN102499906B (zh) * | 2011-10-12 | 2013-04-17 | 长春健欣生物医药科技开发有限公司 | 一种罗替戈汀盐酸盐或自由碱成膜凝胶制剂及其制备方法 |
WO2013075823A1 (en) | 2011-11-22 | 2013-05-30 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermal therapeutic system comprising rotigotine and crystallization inhibitor |
DE102011119043A1 (de) | 2011-11-22 | 2013-05-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TDS) mit Rotigotin |
DE102012013421A1 (de) | 2012-07-03 | 2014-01-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TTS) mit Rotigotin |
DE102012013439A1 (de) | 2012-07-03 | 2014-01-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor |
EP2811986A1 (de) * | 2012-02-08 | 2014-12-17 | Dow Corning Corporation | Silikonemulsionen zur freisetzung von wirkstoffen im gesundheitswesen |
WO2014198422A1 (de) | 2013-06-14 | 2014-12-18 | Tesa Labtec Gmbh | Transdermales therapiesystem (tts) mit rotigotin |
US20150068707A1 (en) * | 2013-09-09 | 2015-03-12 | Nec Corporation | Electronic component cooling apparatus |
JP7212676B2 (ja) * | 2017-09-04 | 2023-01-25 | エルテーエス ローマン テラピー-ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
KR20200046461A (ko) | 2018-10-24 | 2020-05-07 | 에스케이케미칼 주식회사 | 비결정 로티고틴 함유 조성물 및 이의 제조 방법 |
PT3854388T (pt) | 2020-01-24 | 2023-12-11 | Luye Pharma Switzerland Ag | Sistema terapêutico transdérmico com o princípio ativo rotigotina e pelo menos um adesivo de silicone não resistente a aminas |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4373519A (en) * | 1981-06-26 | 1983-02-15 | Minnesota Mining And Manufacturing Company | Composite wound dressing |
US4882352A (en) * | 1986-07-28 | 1989-11-21 | Nelson Research & Development Co. | Method for treating schizophrenia |
US4559222A (en) * | 1983-05-04 | 1985-12-17 | Alza Corporation | Matrix composition for transdermal therapeutic system |
DE3333240A1 (de) * | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US4885308A (en) * | 1984-08-13 | 1989-12-05 | Nelson Research & Development Co. | Method and compositions for treatment of parkinsonism syndrome in mammals |
US4996226A (en) * | 1984-08-13 | 1991-02-26 | Whitby Research, Inc. | Method and compositions for treatment of parkinsonism syndrome in mammels |
US4904247A (en) * | 1984-08-31 | 1990-02-27 | Kendall Company | Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery |
DE3587616D1 (de) * | 1984-12-22 | 1993-11-11 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster. |
US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
US4713244A (en) * | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
US4826686A (en) * | 1985-12-14 | 1989-05-02 | Boehringer Ingelheim Kg | Therapeutic system |
US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
EP0249475A3 (de) * | 1986-06-13 | 1989-10-11 | Alza Corporation | Verzögerte percutane Zuführung |
DD294867A5 (de) * | 1986-07-29 | 1991-10-17 | Gummiwerke Thueringen Gmbh | Verfahren zur herstellung von latextauchartikeln mit fibrinolytischer depotwirkung |
US4737410A (en) * | 1986-11-28 | 1988-04-12 | Minnesota Mining And Manufacturing Company | Polyalkyloxazoline-reinforced acrylic pressure-sensitive adhesive composition |
US4906463A (en) * | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
DE3777128D1 (de) * | 1986-12-25 | 1992-04-09 | Sumitomo Electric Industries | Verfahren zur herstellung eines medizinischen vinylchloridharzmaterials. |
US4857313A (en) * | 1987-05-28 | 1989-08-15 | Warner-Lambert Company | Transdermal drug delivery device comprising copolymers of N-morpholinoethyl methacrylate and 2-hydroxylmethacrylate |
US4814173A (en) * | 1987-09-08 | 1989-03-21 | Warner-Lambert Company | Silicone elastomer transdermal matrix system |
US4898920A (en) * | 1987-10-15 | 1990-02-06 | Dow Corning Corporation | Adhesive compositions, controlled release compositions and transdermal delivery device |
US5035894A (en) * | 1987-10-15 | 1991-07-30 | Dow Corning Corporation | Controlled release compositions and transdermal drug delivery device |
US5071645A (en) * | 1987-10-19 | 1991-12-10 | Ppg Industries, Inc. | Process of producing an active agent delivery device |
US4959208A (en) * | 1987-10-19 | 1990-09-25 | Ppg Industries, Inc. | Active agent delivery device |
US5019378A (en) * | 1987-12-29 | 1991-05-28 | Cuno, Incorporated | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
JPH01186823A (ja) * | 1988-01-21 | 1989-07-26 | Dow Corning Kk | 薬物透過性物質の製造方法 |
US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
US5300291A (en) * | 1988-03-04 | 1994-04-05 | Noven Pharmaceuticals, Inc. | Method and device for the release of drugs to the skin |
US5118676A (en) * | 1988-04-08 | 1992-06-02 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
US5118692A (en) * | 1988-04-08 | 1992-06-02 | Whitby Research, Inc. | Penetration enhances for transdermal delivery of systemic agents |
US4996199A (en) * | 1988-04-08 | 1991-02-26 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
US5166341A (en) * | 1988-07-29 | 1992-11-24 | Dainippon Pharmaceutical Co., Ltd. | 6-amino-1,4-hexahydro-1H-diazepine derivatives |
US5240995A (en) * | 1989-02-09 | 1993-08-31 | Alza Corporation | Electrotransport adhesive |
DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
US5225407A (en) * | 1990-02-22 | 1993-07-06 | Glaxo Group Limited | 5-HT3 receptor antagonists for the treatment of autism |
JP2849937B2 (ja) * | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | 医療用貼付剤 |
JP2875611B2 (ja) * | 1990-08-29 | 1999-03-31 | エーザイ株式会社 | ケイ酸カルシウム含有外用剤 |
US5300299A (en) * | 1991-07-22 | 1994-04-05 | Dow Corning Corporation | Silicone pressure sensitive adhesive containing alkylmethylsiloxane wax and related methods and devices |
US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
AU2454495A (en) * | 1994-05-18 | 1995-12-05 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable preparation for treating urination disorder |
-
1993
- 1993-04-30 US US08/056,076 patent/US5989586A/en not_active Expired - Lifetime
- 1993-10-05 DK DK93923258T patent/DK0662822T3/da active
- 1993-10-05 CA CA002145631A patent/CA2145631C/en not_active Expired - Lifetime
- 1993-10-05 AU AU53211/94A patent/AU5321194A/en not_active Abandoned
- 1993-10-05 CN CN93118244A patent/CN1089469A/zh active Pending
- 1993-10-05 DE DE69329825T patent/DE69329825T2/de not_active Expired - Lifetime
- 1993-10-05 PT PT93923258T patent/PT662822E/pt unknown
- 1993-10-05 EP EP93923258A patent/EP0662822B1/de not_active Expired - Lifetime
- 1993-10-05 JP JP6509398A patent/JPH08504757A/ja active Pending
- 1993-10-05 AT AT93923258T patent/ATE198420T1/de not_active IP Right Cessation
- 1993-10-05 ES ES93923258T patent/ES2155073T3/es not_active Expired - Lifetime
- 1993-10-05 WO PCT/US1993/009510 patent/WO1994007468A1/en active IP Right Grant
- 1993-10-27 TW TW082108949A patent/TW252919B/zh active
-
1995
- 1995-06-07 US US08/474,693 patent/US5840336A/en not_active Expired - Lifetime
-
2001
- 2001-03-23 GR GR20010400471T patent/GR3035626T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0662822A1 (de) | 1995-07-19 |
WO1994007468A1 (en) | 1994-04-14 |
TW252919B (de) | 1995-08-01 |
PT662822E (pt) | 2001-04-30 |
US5840336A (en) | 1998-11-24 |
CN1089469A (zh) | 1994-07-20 |
US5989586A (en) | 1999-11-23 |
ATE198420T1 (de) | 2001-01-15 |
DK0662822T3 (da) | 2001-01-29 |
JPH08504757A (ja) | 1996-05-21 |
CA2145631C (en) | 2004-02-10 |
EP0662822B1 (de) | 2001-01-03 |
CA2145631A1 (en) | 1994-04-14 |
EP0662822A4 (de) | 1996-08-07 |
AU5321194A (en) | 1994-04-26 |
ES2155073T3 (es) | 2001-05-01 |
GR3035626T3 (en) | 2001-06-29 |
DE69329825T2 (de) | 2001-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69329825D1 (de) | Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung | |
US4810499A (en) | Transdermal drug delivery system and method | |
DE3685895D1 (de) | Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen. | |
EP0279977A3 (de) | Transdermale Verabreichung von Progesteron, Östradiolestern und deren Mischungen | |
DE3879853D1 (de) | Klebstoffzusammensetzung, zusammensetzung mit kontrollierter wirkstofffreisetzung und system zur transdermalen anwendung von arzneien. | |
DE69414502T2 (de) | Medizinische Vorrichtung zur Verabreichung von Aktivsubstanzen oder Arzneistoffen in sehr niedriger Dosis, insbesondere von homöopatischen Arzneistoffen | |
DE3687458D1 (de) | Filmbildende arzneimitteltraeger zur verabreichung von arzneimitteln an naegeln | |
IE860306L (en) | Drug delivery system | |
ATE238778T1 (de) | Transdermales therapeutisches system zur abgabe von hormonen | |
PT957900E (pt) | Composicoes e metodos para aplicacao topica de agentes terapeuticos | |
KR900015761A (ko) | 경피성 단일체 시스템 | |
EP0737477A4 (de) | Transdermale pharmazeutische zubereitung | |
PT93191A (pt) | Sistema terapeutico para a administracao retardada e controlada transdermica ou transmucosica de substancias activas | |
PT706401E (pt) | Sistema para administracao de farmacos | |
ZA901940B (en) | A plaster used as therapeutic system for the administration of active substances to the skin | |
DE3766308D1 (de) | Kombination von carbidopa/levodopa mit verzoegerter wirkstoffabgabe. | |
ES2016620B3 (es) | Sistema para liberar medicamentos con bioaceptabilidad mejorada. | |
MY107420A (en) | Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances. | |
ATE295157T1 (de) | Mittel zur transdermalen verabreichung von arzneistoffen | |
BR9607169A (pt) | Uso de meletonina e formulação farmacêutica para uso no tratamento de um viciado em drogas múltiplas | |
AR003413A1 (es) | Parches medicinales para la administracion transdermica de risperidona con liberacion controlada a traves de la piel intacta durante un periodo de tiempo prolongado | |
HUP9904181A2 (hu) | Felületstabilizált gyógyszerészeti készítmény bőrön való alkalmazáshoz | |
BR9406900A (pt) | Sistema de transporte transdermal molecular | |
MX9706031A (es) | Una formulacion de liberacion controlada para farmacos basicos deficientemente solubles. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |