CN108699153B - Pd-l1的结合成员 - Google Patents

Pd-l1的结合成员 Download PDF

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Publication number
CN108699153B
CN108699153B CN201780012727.3A CN201780012727A CN108699153B CN 108699153 B CN108699153 B CN 108699153B CN 201780012727 A CN201780012727 A CN 201780012727A CN 108699153 B CN108699153 B CN 108699153B
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binding member
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gly
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binding
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CN108699153A (zh
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A·沙姆谢夫
T·克雷兹施玛
M·德罗斯特
D·菲利普斯
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Cell Medicine Co
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Cell Medica Switzerland AG
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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CN201780012727.3A 2016-02-25 2017-02-24 Pd-l1的结合成员 Expired - Fee Related CN108699153B (zh)

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CN202211150762.0A CN116082505A (zh) 2016-02-25 2017-02-24 Pd-l1的结合成员

Applications Claiming Priority (3)

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EP16020057.2 2016-02-25
EP16020057 2016-02-25
PCT/EP2017/054367 WO2017144681A1 (en) 2016-02-25 2017-02-24 Binding members to pd-l1

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CN108699153B true CN108699153B (zh) 2022-09-23

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CN201780012682.XA Expired - Fee Related CN108884164B (zh) 2016-02-25 2017-02-24 用于免疫疗法的经修饰细胞
CN201780012727.3A Expired - Fee Related CN108699153B (zh) 2016-02-25 2017-02-24 Pd-l1的结合成员

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US (3) US11434294B2 (enExample)
EP (3) EP3420000A1 (enExample)
JP (3) JP7080819B2 (enExample)
KR (2) KR20190003938A (enExample)
CN (3) CN116082505A (enExample)
AU (2) AU2017223846A1 (enExample)
BR (2) BR112018067696A2 (enExample)
CA (2) CA3014067A1 (enExample)
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RU (2) RU2018128462A (enExample)
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EP3420000A1 (en) * 2016-02-25 2019-01-02 Cell Medica Switzerland AG Modified cells for immunotherapy
TWI755395B (zh) 2016-05-13 2022-02-21 美商再生元醫藥公司 抗-pd-1抗體與輻射治療癌症之組合
GB201617714D0 (en) * 2016-10-19 2016-11-30 Ucl Business Plc T Cell receptor
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US11278570B2 (en) 2016-12-16 2022-03-22 B-Mogen Biotechnologies, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
IL268479B2 (en) 2017-02-21 2024-06-01 Regeneron Pharma Anti-PD-1 antibodies for the treatment of lung cancer
AU2018251898A1 (en) 2017-04-13 2019-10-31 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EP3628070B1 (en) 2017-04-28 2021-09-08 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides for use in increasing central memory t cells
KR20250010750A (ko) * 2017-12-20 2025-01-21 포세이다 테라퓨틱스, 인크. Vcar 조성물 및 사용 방법
KR102795692B1 (ko) 2018-01-19 2025-04-16 밀테니 비오텍 비.브이. & 씨오. 케이지 키메라 항원 수용체를 발현하는 조절 t 세포
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