CN108601731A - 新抗原的鉴别、制造及使用 - Google Patents

新抗原的鉴别、制造及使用 Download PDF

Info

Publication number
CN108601731A
CN108601731A CN201680080924.4A CN201680080924A CN108601731A CN 108601731 A CN108601731 A CN 108601731A CN 201680080924 A CN201680080924 A CN 201680080924A CN 108601731 A CN108601731 A CN 108601731A
Authority
CN
China
Prior art keywords
peptide
hla
sequence
mhc
neoantigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680080924.4A
Other languages
English (en)
Chinese (zh)
Inventor
R·耶冷斯凯
A·德里蒂
B·布里克-沙利文
J·巴斯比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gritstone Bio Inc
Original Assignee
Gritstone Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59057557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108601731(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gritstone Oncology Inc filed Critical Gritstone Oncology Inc
Priority to CN202510092422.4A priority Critical patent/CN119905147A/zh
Publication of CN108601731A publication Critical patent/CN108601731A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F19/00—Advertising or display means not otherwise provided for
    • G09F19/12—Advertising or display means not otherwise provided for using special optical effects
    • G09F19/16—Advertising or display means not otherwise provided for using special optical effects involving the use of mirrors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/40—Encryption of genetic data
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Theoretical Computer Science (AREA)
  • Microbiology (AREA)
  • Evolutionary Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Bioethics (AREA)
CN201680080924.4A 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用 Pending CN108601731A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510092422.4A CN119905147A (zh) 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562268333P 2015-12-16 2015-12-16
US62/268,333 2015-12-16
US201662317823P 2016-04-04 2016-04-04
US62/317,823 2016-04-04
US201662379986P 2016-08-26 2016-08-26
US62/379,986 2016-08-26
US201662394074P 2016-09-13 2016-09-13
US62/394,074 2016-09-13
US201662425995P 2016-11-23 2016-11-23
US62/425,995 2016-11-23
PCT/US2016/067159 WO2017106638A1 (en) 2015-12-16 2016-12-16 Neoantigen identification, manufacture, and use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510092422.4A Division CN119905147A (zh) 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用

Publications (1)

Publication Number Publication Date
CN108601731A true CN108601731A (zh) 2018-09-28

Family

ID=59057557

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680080924.4A Pending CN108601731A (zh) 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用
CN202510092422.4A Pending CN119905147A (zh) 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202510092422.4A Pending CN119905147A (zh) 2015-12-16 2016-12-16 新抗原的鉴别、制造及使用

Country Status (18)

Country Link
US (7) US20170199961A1 (https=)
EP (2) EP4299136A3 (https=)
JP (3) JP7114477B2 (https=)
KR (2) KR102883915B1 (https=)
CN (2) CN108601731A (https=)
AU (2) AU2016369519B2 (https=)
BR (1) BR112018012374A2 (https=)
CA (1) CA3008641A1 (https=)
CO (1) CO2018007417A2 (https=)
ES (1) ES2970865T3 (https=)
IL (3) IL305238B2 (https=)
MX (2) MX2018007204A (https=)
PE (1) PE20181535A1 (https=)
PH (1) PH12018501267A1 (https=)
RU (1) RU2729116C2 (https=)
SG (1) SG11201804957VA (https=)
TW (1) TWI765875B (https=)
WO (1) WO2017106638A1 (https=)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109706065A (zh) * 2018-12-29 2019-05-03 深圳裕策生物科技有限公司 肿瘤新生抗原负荷检测装置及存储介质
CN109801678A (zh) * 2019-01-25 2019-05-24 上海鲸舟基因科技有限公司 基于全转录组的肿瘤抗原预测方法及其应用
CN110172513A (zh) * 2019-05-30 2019-08-27 浙江自贸区锐赛生物医药科技有限公司 突变型免疫多肽临床入组的筛选方法
CN110456079A (zh) * 2019-09-20 2019-11-15 四川大学华西医院 Tapbp自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN110675913A (zh) * 2019-01-16 2020-01-10 倍而达药业（苏州）有限公司 一种基于hla分型与结构的肿瘤新抗原的筛选方法
CN110706747A (zh) * 2019-09-17 2020-01-17 北京橡鑫生物科技有限公司 检测肿瘤新生抗原多肽的方法和装置
CN111303268A (zh) * 2020-03-10 2020-06-19 江苏兰恩生物治疗技术研究院有限公司 子宫肌瘤新抗原、其应用和子宫肌瘤疫苗
CN111621564A (zh) * 2019-02-28 2020-09-04 武汉大学 一种鉴定有效肿瘤新抗原的方法
CN113316818A (zh) * 2019-03-15 2021-08-27 痕准生物科技有限公司 新生抗原的鉴定方法
CN113412519A (zh) * 2019-02-11 2021-09-17 旗舰开拓创新六世公司 机器学习引导的多肽分析
CN113424264A (zh) * 2018-11-15 2021-09-21 Nouscom股份公司 用于生成个性化癌症疫苗的癌症突变选择
CN113474840A (zh) * 2018-12-21 2021-10-01 百欧恩泰美国公司 用于预测hla ii类特异性表位及表征cd4+ t细胞的方法和系统
CN113807468A (zh) * 2021-10-15 2021-12-17 南京澄实生物科技有限公司 基于多模态深度编码的hla抗原呈递预测方法和系统
CN120877859A (zh) * 2025-07-10 2025-10-31 北京深势科技有限公司 一种基于自由能变进行突变位点筛选的处理方法和装置

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105190656B (zh) 2013-01-17 2018-01-16 佩索纳里斯公司 用于遗传分析的方法和系统
WO2014180490A1 (en) 2013-05-10 2014-11-13 Biontech Ag Predicting immunogenicity of t cell epitopes
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
EP3194970B1 (en) 2014-09-10 2021-07-28 F. Hoffmann-La Roche AG Immunogenic mutant peptide screening platform
US11338026B2 (en) 2014-09-10 2022-05-24 The University Of Connecticut Identification of immunologically protective neo-epitopes for the treatment of cancers
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
WO2016128060A1 (en) 2015-02-12 2016-08-18 Biontech Ag Predicting t cell epitopes useful for vaccination
EP3364949A4 (en) 2015-10-22 2019-07-31 ModernaTX, Inc. CANCER VACCINES
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
WO2017194170A1 (en) 2016-05-13 2017-11-16 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of proteins or protein fragments for immunotherapy
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
PT3488443T (pt) * 2016-07-20 2021-09-24 BioNTech SE Seleção de neoepítopos como alvos específicos da doença para terapia com eficácia melhorada
CN106295678B (zh) * 2016-07-27 2020-03-06 北京旷视科技有限公司 神经网络训练与构建方法和装置以及目标检测方法和装置
US11927591B2 (en) * 2016-08-02 2024-03-12 Georgetown University Methods of identifying novel proteins and antigens in cancer cells
PE20191345A1 (es) 2016-11-23 2019-09-30 Gritstone Oncology Inc Administracion viral de neoantigenos
CA3045811A1 (en) 2016-12-01 2018-06-07 Nantomics, Llc Tumor antigenicity processing and presentation
WO2018136664A1 (en) * 2017-01-18 2018-07-26 Ichan School Of Medicine At Mount Sinai Neoantigens and uses thereof for treating cancer
WO2018148671A1 (en) * 2017-02-12 2018-08-16 Neon Therapeutics, Inc. Hla-based methods and compositions and uses thereof
EP3568811B1 (en) * 2017-02-24 2024-10-16 DeepMind Technologies Limited Training machine learning models
KR102841050B1 (ko) * 2017-04-19 2025-08-01 그릿스톤 바이오, 인코포레이티드 신생항원 동정, 제조, 및 용도
MX2019013259A (es) 2017-05-08 2020-01-13 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus.
WO2018224166A1 (en) 2017-06-09 2018-12-13 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
KR20240113607A (ko) * 2017-06-21 2024-07-22 트랜스진 개인 맞춤형 백신
WO2019006022A1 (en) * 2017-06-27 2019-01-03 The Broad Institute, Inc. SYSTEMS AND METHODS FOR PREDICTING MHC CLASS II EPITOPE
EP3651791A1 (en) * 2017-07-14 2020-05-20 The Francis Crick Institute Limited Analysis of hla alleles in tumours and the uses thereof
CN111727262A (zh) * 2017-07-25 2020-09-29 加州理工学院 胞啃介导的表位发现
JP6928948B2 (ja) * 2017-08-09 2021-09-01 学校法人日本大学 口臭判定装置及びプログラム
CN110997903B (zh) * 2017-08-10 2024-03-29 古德T细胞有限公司 用于癌症治疗的t细胞的活化方法
JP7763588B2 (ja) * 2017-09-05 2025-11-04 グリットストーン バイオ インコーポレイテッド Ｔ細胞療法用の新生抗原の特定法
KR20260039788A (ko) * 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
US11861491B2 (en) 2017-10-16 2024-01-02 Illumina, Inc. Deep learning-based pathogenicity classifier for promoter single nucleotide variants (pSNVs)
WO2019079182A1 (en) 2017-10-16 2019-04-25 Illumina, Inc. SEMI-SUPERVISED APPRENTICESHIP FOR THE LEARNING OF A SET OF NEURONAL NETWORKS WITH DEEP CONVOLUTION
SG11201912745WA (en) * 2017-10-16 2020-01-30 Illumina Inc Deep learning-based splice site classification
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
CN109682978B (zh) * 2017-11-30 2020-07-03 四川康德赛医疗科技有限公司 一种肿瘤突变肽mhc亲和力预测方法及其应用
EP3735271A4 (en) 2018-01-04 2022-06-15 Iconic Therapeutics, Inc. ANTI-TISSUE FACTOR ANTIBODIES, ANTIBODY DRUG CONJUGATES AND RELATED METHODS
CN119851752A (zh) * 2018-02-27 2025-04-18 磨石生物公司 利用泛等位基因模型进行的新抗原鉴别
US20210020270A1 (en) * 2018-03-08 2021-01-21 The Trustees Of Indiana University Constrained de novo sequencing of neo-epitope peptides using tandem mass spectrometry
US20210158895A1 (en) * 2018-04-13 2021-05-27 Dana-Farber Cancer Institute, Inc. Ultra-sensitive detection of cancer by algorithmic analysis
KR102212663B1 (ko) * 2018-05-22 2021-02-05 주식회사 석영시스템즈 목표 온도를 기반으로 하는 빌딩의 열·공조 시스템에 대한 공급 전력 제어 방법 및 장치
CN112368386A (zh) * 2018-05-23 2021-02-12 磨石肿瘤生物技术公司 共有抗原
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
WO2020022899A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
CA3106562A1 (en) * 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Off-the-shelf cancer vaccines
IL280651B2 (en) * 2018-08-30 2024-05-01 Univ Montreal Proteogenomic-based method for identifying tumor-specific antigens
CN112771214B (zh) 2018-09-27 2025-06-13 耐考德治疗股份有限公司 用于选择新表位的方法
WO2020072700A1 (en) * 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
US20220088174A1 (en) * 2018-10-26 2022-03-24 Dana-Farber Cancer Institute, Inc. Genomic variants in ig gene regions and uses of same
WO2020092382A1 (en) * 2018-10-29 2020-05-07 Health Research, Inc. Cancer specific immunotherapeutic targets generated by chemotherapeutic drug treatment
JP7239300B2 (ja) * 2018-11-01 2023-03-14 浜松ホトニクス株式会社 スペクトル分析装置およびスペクトル分析方法
CA3115017C (en) 2018-11-21 2023-10-31 Nec Corporation Method and system of targeting epitopes for neoantigen-based immunotherapy
WO2020132235A1 (en) * 2018-12-20 2020-06-25 Merck Sharp & Dohme Corp. Methods and systems for the precise identification of immunogenic tumor neoantigens
EP4582440A3 (en) * 2018-12-21 2025-10-08 The Regents of the University of California Il-10-containing vaccines and uses thereof
CN109712672B (zh) * 2018-12-29 2021-05-25 北京优迅医学检验实验室有限公司 检测基因重排的方法、装置、存储介质及处理器
EP3906045A1 (en) 2019-01-03 2021-11-10 Evaxion Biotech ApS Vaccines targeting neoepitopes
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
US20220098578A1 (en) * 2019-01-31 2022-03-31 Bar Ilan University Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy
SG11202109073VA (en) 2019-02-20 2021-09-29 Rubius Therapeutics Inc Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use
TWI894138B (zh) * 2019-03-06 2025-08-21 美商西雅圖項目公司 利用ii 類mhc 模型鑑別新抗原
AU2020234003B2 (en) 2019-03-11 2026-02-12 Evaxion A/S Nucleic acid vaccination using neo-epitope encoding constructs
US12427195B1 (en) * 2019-03-11 2025-09-30 La Jolla Institute For Immunology Methods of neoantigen identification
US11599774B2 (en) * 2019-03-29 2023-03-07 International Business Machines Corporation Training machine learning model
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CA3145833A1 (en) * 2019-07-02 2021-01-07 Roman YELENSKY Hiv antigens and mhc complexes
CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
EP4028763A1 (en) * 2019-09-13 2022-07-20 Evaxion Biotech A/S Method for identifying t-cell epitopes
US12394502B2 (en) * 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
EP4055610A4 (en) 2019-11-05 2023-11-29 Personalis, Inc. ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES
US20230072079A1 (en) 2019-12-18 2023-03-09 Evaxion Biotech A/S Nucleic acid vaccination using neo-epitope encoding constructs
CN114929899B (zh) 2020-01-07 2026-03-10 韩国科学技术院 一种新抗原的筛选方法、系统及其用途
AU2021253641A1 (en) 2020-04-07 2022-10-27 Evaxion Biotech A/S Neoepitope immunotherapy with APC targeting unit
US11920202B2 (en) 2020-04-09 2024-03-05 University Of Connecticut Unbiased identification of tumor rejection mediating neoepitopes
WO2021222121A1 (en) * 2020-04-27 2021-11-04 Flagship Pioneering Innovations Vi, Llc Optimizing proteins using model based optimizations
CN116437951A (zh) * 2020-05-19 2023-07-14 磨石生物公司 Sars-cov-2疫苗
US12295997B2 (en) 2020-07-06 2025-05-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022013154A1 (en) 2020-07-14 2022-01-20 Myneo Nv Method, system and computer program product for determining presentation likelihoods of neoantigens
US20230355733A1 (en) 2020-07-14 2023-11-09 Evaxion Biotech A/S APC targeting units for immunotherapy
KR20230046313A (ko) 2020-08-06 2023-04-05 그릿스톤 바이오, 인코포레이티드 다중에피토프 백신 카세트
EP4192941A1 (en) 2020-08-07 2023-06-14 Neogene Therapeutics B.V. Methods to enrich genetically engineered t cells
US20220139498A1 (en) * 2020-11-04 2022-05-05 Basf Corporation Apparatuses, systems, and methods for extracting meaning from dna sequence data using natural language processing (nlp)
US20230197192A1 (en) * 2020-11-06 2023-06-22 Amazon Technologies, Inc. Selecting neoantigens for personalized cancer vaccine
EP4277652A1 (en) 2021-01-14 2023-11-22 Gilead Sciences, Inc. Hiv vaccines and methods of using
US12567480B2 (en) * 2021-01-19 2026-03-03 Amazon Technologies, Inc. Deep learning model for predicting tumor-specific neoantigen MHC class I or class II immunogenicity
US20220319635A1 (en) * 2021-04-05 2022-10-06 Nec Laboratories America, Inc. Generating minority-class examples for training data
US20220327425A1 (en) * 2021-04-05 2022-10-13 Nec Laboratories America, Inc. Peptide mutation policies for targeted immunotherapy
CN113129998B (zh) * 2021-04-23 2022-06-21 云测智能科技有限公司 临床个体化肿瘤新抗原的预测模型构建方法
CA3216276A1 (en) 2021-04-29 2022-11-03 Yardena Samuels T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same
EP4330380A1 (en) 2021-04-30 2024-03-06 Tigen Pharma SA Single vessel expansion of lymphocytes
CN117813108A (zh) * 2021-05-27 2024-04-02 亚马逊科技公司 基于肽的新抗原疫苗的多组分化学组合物
EP4413580A4 (en) 2021-10-05 2025-08-13 Personalis Inc PERSONALIZED TESTS FOR PERSONALIZED CANCER MONITORING
CN113762416B (zh) * 2021-10-15 2023-05-30 南京澄实生物科技有限公司 基于多模态深度编码的抗原免疫原性预测方法和系统
WO2023177655A1 (en) 2022-03-14 2023-09-21 Generation Bio Co. Heterologous prime boost vaccine compositions and methods of use
TWI805290B (zh) * 2022-03-28 2023-06-11 臺北醫學大學 用於預測肺腺癌是否具有表皮生長因子受體突變的方法
US20230368872A1 (en) * 2022-05-16 2023-11-16 Spencer Health Solutions, Llc Alert decision support system based on patient quality of life survey information and related methods and computer program products
JP2025541604A (ja) 2022-11-02 2025-12-22 ティゲン・ファーマ・ソシエテ・アノニム リンパ球の拡大
WO2024261339A1 (en) 2023-06-23 2024-12-26 Tigen Pharma Sa Lymphocyte-stimulatory matrix (lsm) and uses thereof for expansion of lymphocyte populations
US20250140344A1 (en) 2023-10-31 2025-05-01 Tempus Ai, Inc. T cell receptor screening methods
WO2025137574A1 (en) * 2023-12-21 2025-06-26 Moonshot Antibodies, Llc Methods for treatment of cancer with polynucleotides or antibodies that target mutated cell surface related proteins
CN118314949B (zh) * 2024-04-26 2024-12-13 海南大学 一种抗癌肽预测方法及相关装置
CN118351934B (zh) * 2024-04-26 2025-01-28 广州润生细胞医药科技有限责任公司 一种基于二代测序数据的肿瘤新抗原识别方法及系统
CN119446264B (zh) * 2025-01-09 2025-05-06 天津市肿瘤医院空港医院 一种恶性实体肿瘤的新抗原预测方法及系统
CN120708721B (zh) * 2025-08-15 2026-03-17 北京悦康科创医药科技股份有限公司 一种肿瘤新抗原筛选方法、装置、设备、存储介质及产品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103180730A (zh) * 2010-05-14 2013-06-26 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法
CN103415534A (zh) * 2009-03-10 2013-11-27 贝勒研究院 靶向抗原呈递细胞的癌症疫苗

Family Cites Families (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
ES2067018T3 (es) 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5130538A (en) 1989-05-19 1992-07-14 John B. Fenn Method of producing multiply charged ions and for determining molecular weights of molecules by use of the multiply charged ions of molecules
JPH04501468A (ja) 1989-05-19 1992-03-12 フェン，ジョン，ビー 多重帯電イオンおよび大分子の分子量の決定方法
US5581080A (en) 1989-05-19 1996-12-03 Fenn; John B. Method for determining molecular weight using multiply charged ions
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
ATE157012T1 (de) 1989-11-03 1997-09-15 Univ Vanderbilt Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen
DE69133064T2 (de) 1990-02-26 2003-03-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Identifizierung und expression von insekten-steroidrezeptor-dns-sequenzen
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
US5608217A (en) 1994-03-10 1997-03-04 Bruker-Franzen Analytik Gmbh Electrospraying method for mass spectrometric analysis
DE4444229C2 (de) 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US8114414B2 (en) 1994-11-08 2012-02-14 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical cancer
US8956621B2 (en) 1994-11-08 2015-02-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical dysplasia
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
JP2001520013A (ja) 1997-10-10 2001-10-30 ビーエーエスエフ アクチェンゲゼルシャフト Ｔ細胞受容体−会合分子（ｔａｒｍｓ）及びその使用方法
DE19937828C1 (de) 1999-08-11 2000-10-05 Smb Schwede Maschinenbau Gmbh Schweißkopf für eine Bandumreifungsmaschine
AU7508100A (en) 1999-10-04 2001-05-10 Jens Andersen Human seizure related proteins
JP5031967B2 (ja) 2000-03-22 2012-09-26 イントレキソン コーポレーション 新規エクジソン受容体ベースの誘導性遺伝子発現系
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US7268207B2 (en) * 2000-04-04 2007-09-11 University Of Rochester Gene differentially expressed in breast and bladder cancer, and encoded polypeptides
WO2001094935A2 (en) 2000-06-09 2001-12-13 Mds Proteomics, Inc. Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
GB0018901D0 (en) * 2000-08-03 2000-09-20 Biovation Ltd Peptides presented by cells
WO2002037121A2 (en) 2000-10-25 2002-05-10 Mds Proteomics, Inc. Detection of modified amino acids by mass spectrometry
ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
US20030175722A1 (en) 2001-04-09 2003-09-18 Matthias Mann Methods and systems for searching genomic databases
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US20040002112A1 (en) 2001-10-31 2004-01-01 Matthias Mann Proteins involved in regulation of adipocytes and uses related thereto
DE10211088A1 (de) 2002-03-13 2003-09-25 Ugur Sahin Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
AU2003232485A1 (en) 2002-04-18 2003-10-27 Mtm Laboratories Ag Neopeptides and methods useful for detection and treatment of cancer
US20050221350A1 (en) 2002-05-29 2005-10-06 Toni Weinschenk Method for identifying immunoreactive peptides
US7176022B2 (en) 2002-12-20 2007-02-13 Cell Genesys, Inc. Directly injectable formulations which provide enhanced cryoprotection of cell products
US7833775B2 (en) 2003-02-06 2010-11-16 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
KR101192652B1 (ko) 2003-02-06 2012-10-19 앤저 테라퓨틱스 인코퍼레이티드 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
CA2517396A1 (en) 2003-02-28 2005-03-10 Antigenics Inc. Use of lectins to promote oligomerization of glycoproteins and antigenic molecules
US20040197312A1 (en) 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
DE10341812A1 (de) 2003-09-10 2005-04-07 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
DE10344799A1 (de) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
CA2551644C (en) 2003-12-24 2014-03-04 Cerus Corporation Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of usethereof
DE102004023187A1 (de) 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
US20070265818A1 (en) 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for heightening cell-mediated immune response
US20060095241A1 (en) 2004-10-29 2006-05-04 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7283337B2 (en) 2005-03-04 2007-10-16 Headway Technologies, Inc. Abutted exchange bias design for sensor stabilization
DE102005013846A1 (de) 2005-03-24 2006-10-05 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
ES2341802T3 (es) 2005-09-05 2010-06-28 Immatics Biotechnologies Gmbh Peptidos asociados a tumores unidos promiscuamente a moleculas del antigeno de leucocito humano (hla) de clase ii.
EP1762575A1 (en) 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identification of tumor-associated antigens for diagnosis and therapy
CA2651796A1 (en) 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
US9732131B2 (en) 2006-02-27 2017-08-15 Calviri, Inc. Identification and use of novopeptides for the treatment of cancer
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
WO2007103225A2 (en) 2006-03-01 2007-09-13 Anza Therapeutics, Inc. Engineered listeria and methods of use thereof
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
DE102006032362A1 (de) 2006-07-13 2008-01-17 Khd Humboldt Wedag Gmbh Rollenpresse insbesondere zur Gutbettzerkleinerung
WO2008094188A2 (en) 2006-07-17 2008-08-07 Anza Therapeutics, Inc. Methods and compositions using listeria for enhancing immunogenicity by prime boost
US8121797B2 (en) 2007-01-12 2012-02-21 Microsoft Corporation T-cell epitope prediction
US9085638B2 (en) 2007-03-07 2015-07-21 The Johns Hopkins University DNA vaccine enhancement with MHC class II activators
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
PL2565204T3 (pl) 2007-07-27 2016-03-31 Immatics Biotechnologies Gmbh Nowe immunogenne epitopy do immunoterapii
BRPI0813621A2 (pt) 2007-07-27 2017-05-09 Immatics Biotechnologies Gmbh imunoterapia contra tumores neuronais e cerebrais
EA018457B1 (ru) 2007-07-27 2013-08-30 Имматикс Байотекнолоджиз Гмбх Композиция опухолеассоциированных пептидов и относящаяся к ним противораковая вакцина
US20100286070A1 (en) 2007-09-14 2010-11-11 Gert Verheyden Affinity tag
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
WO2009072003A2 (en) 2007-12-07 2009-06-11 Miltenyi Biotec Gmbh Sample processing system and methods
EP2091046A1 (en) 2008-02-15 2009-08-19 Thomson Licensing Presentation system and method for controlling the same
PT2113253E (pt) 2008-04-30 2010-06-15 Immatics Biotechnologies Gmbh Formulações novas de peptídeos associados a tumores que se ligam a moléculas de classe i ou ii do antígeno leucocitário humano (hla) para vacinas
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
SI2119726T2 (en) 2008-05-14 2018-03-30 Immatics Biotechnologies Gmbh New and powerful Class II MHC peptides derived from survivin and neurocane
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US20150366955A9 (en) 2009-11-11 2015-12-24 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US20110129499A1 (en) 2008-05-19 2011-06-02 Paulo Maciag Dual delivery system for heterologous antigens
CN102076843A (zh) 2008-05-19 2011-05-25 艾杜罗生物科技公司 包含prfa*突变体李斯特菌的组合物及其使用方法
US20140234370A1 (en) 2009-11-11 2014-08-21 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors
US8840881B2 (en) 2008-08-28 2014-09-23 Aduro Gvax Inc. Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
PL2172211T3 (pl) 2008-10-01 2015-05-29 Immatics Biotechnologies Gmbh Kompozycja związanych z guzem peptydów i związana z tym szczepionka przeciwrakowa do leczenia glejaka (GBM) i innych rodzajów raka
HUE045093T2 (hu) 2008-11-21 2019-12-30 Kobenhavns Univ University Of Copenhagen Immunválasz kiváltása
CA2919467C (en) 2009-03-02 2018-04-17 Jan Paul Medema Antibodies against a proliferating inducing ligand (april)
WO2010106535A1 (en) 2009-03-15 2010-09-23 Technion Research And Development Foundation Ltd. Soluble hla complexes for use in disease diagnosis
AU2010232490B2 (en) 2009-04-03 2016-08-11 Agenus Inc. Methods for preparing and using multichaperone-antigen complexes
EP2309262A1 (en) 2009-10-06 2011-04-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for quantifying biomolecules
EP2498808A4 (en) 2009-11-11 2014-01-08 Advaxis COMPOSITIONS AND METHOD FOR PREVENTING FLUID MUTATIONS IN THE TREATMENT OF TUMORS WITH HER2 / NEW OVEREXPRESSION
US20110223187A1 (en) 2010-02-15 2011-09-15 Vafa Shahabi Live listeria-based vaccines for central nervous system therapy
GB201004551D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
GB201004575D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
ES2613630T3 (es) 2010-05-23 2017-05-25 Aduro Biotech, Inc. Métodos y composiciones que utilizan Listeria para un tratamiento auxiliar del cáncer
EP2576614A4 (en) 2010-05-24 2013-11-13 Phosimmune Inc CLASS I-MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS
AU2011275749C1 (en) 2010-07-09 2015-09-17 Aduro Biotech Holdings, Europe B.V. Agonistic antibody to CD27
US20130303594A1 (en) 2010-09-14 2013-11-14 Max-Planok-Gesellschaft Zur Forderung Der Wissenschaften E.V. Hot1 and uses thereof
GB201015765D0 (en) 2010-09-21 2010-10-27 Immatics Biotechnologies Gmbh Use of myeloid cell biomarkers for the diagnosis of cancer
US9226958B2 (en) 2010-10-01 2016-01-05 University Of Georgia Research Foundation, Inc. Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
RS57630B1 (sr) 2010-11-17 2018-11-30 Aduro Biotech Inc Metode i sastavi za uzrokovanje imunog odgovora na egfrviii
GB201021289D0 (en) 2010-12-15 2011-01-26 Immatics Biotechnologies Gmbh Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer
KR20190002733A (ko) 2010-12-30 2019-01-08 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
AU2012229218B2 (en) 2011-03-11 2017-03-02 Advaxis, Inc. Listeria-based adjuvants
EP2508537A1 (en) 2011-04-04 2012-10-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Quantitative standard for mass spectrometry of proteins
HRP20211595T1 (hr) 2011-05-24 2022-01-21 BioNTech SE Individualizirana cjepiva protiv raka
EP2607375A1 (en) 2011-12-21 2013-06-26 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Variants of yeast NDI1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction.
CN104411327A (zh) 2012-03-12 2015-03-11 阿德瓦希斯公司 李斯特菌疫苗治疗以后的抑制细胞功能抑制
WO2013158611A1 (en) 2012-04-16 2013-10-24 Agenus Inc. Methods and compositions for the treatment of glioblastomas
CA2879024A1 (en) 2012-07-12 2014-01-16 Persimmune, Inc. Personalized cancer vaccines and adoptive immune cell therapies
EP2893061B1 (en) 2012-09-05 2019-05-22 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Methods for discovering therapeutic targets
WO2014075788A1 (en) 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2014082729A1 (en) 2012-11-28 2014-06-05 Biontech Ag Individualized vaccines for cancer
PL2931738T3 (pl) 2012-12-13 2019-07-31 Aduro Biotech, Inc. Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania
CA2895578A1 (en) 2012-12-19 2014-06-26 Nils A. KULAK Reaction vessel for sample preparation
WO2014106123A1 (en) 2012-12-27 2014-07-03 Aduro Biotech, Inc. Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
EP4303232A3 (en) 2013-02-15 2024-04-17 The Regents of The University of California Chimeric antigen receptor and methods of use thereof
CN118750591A (zh) 2013-04-07 2024-10-11 博德研究所 用于个性化瘤形成疫苗的组合物和方法
WO2014180490A1 (en) 2013-05-10 2014-11-13 Biontech Ag Predicting immunogenicity of t cell epitopes
RS59500B1 (sr) 2013-05-18 2019-12-31 Aduro Biotech Inc Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
US11069427B2 (en) * 2013-06-10 2021-07-20 Iogenetics, Llc Mathematical processes for determination of peptidase cleavage
EP3027203B1 (en) 2013-07-30 2020-07-29 BioNTech SE Tumor antigens for determining cancer therapy
AU2014298504B2 (en) 2013-07-30 2018-08-30 Biontech Ag Tumor antigens for determining cancer therapy
CA2917858A1 (en) 2013-08-02 2015-02-05 Aduro Biotech Holdings, Europe B.V. Combining cd27 agonists and immune checkpoint inhibition for immune stimulation
TWI775117B (zh) 2013-08-05 2022-08-21 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二）
PL2959021T3 (pl) 2013-08-19 2018-11-30 Biontech Diagnostics Gmbh Sposoby i zestawy do podtypowania molekularnego guzów
CN110468205A (zh) 2013-08-19 2019-11-19 拜恩科技诊断有限责任公司 用于肿瘤分子亚型分型的方法和试剂盒
WO2015030585A2 (en) 2013-08-27 2015-03-05 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Methods for detecting post-translationally modified lysines in a polypeptide
CA2921639A1 (en) 2013-09-05 2015-03-12 Aduro Biotech Holdings, Europe B.V. Cd70-binding peptides and method, process and use relating thereto
NL2011406C2 (en) 2013-09-06 2015-03-10 Bionovion Holding B V Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides.
CA2925047C (en) 2013-09-26 2021-03-23 Biontech Ag Rna decorated particles
WO2015058780A1 (en) 2013-10-25 2015-04-30 Biontech Ag Method and kit for determining whether a subject shows an immune response
EP3060679B1 (en) 2013-10-25 2019-06-12 BioNTech Diagnostics GmbH Method and kit for determining whether a subject shows an immune response
JP2016535989A (ja) 2013-11-01 2016-11-24 ファイザー・インク 前立腺関連抗原を発現させるためのベクター
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) * 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
PE20161344A1 (es) 2014-01-02 2016-12-23 Memorial Sloan Kettering Cancer Center Determinantes de respuesta del cancer a la inmunoterapia
CN111909278B (zh) * 2014-01-27 2024-04-09 分子模板公司 Mhc i类表位递送多肽
EP3099706B1 (en) 2014-01-29 2018-10-31 BioNTech AG Peptide mimotopes of claudin 18.2 and uses thereof
JP6580579B2 (ja) 2014-01-29 2019-09-25 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体を発現する細胞を生産する方法および組成物
US10143734B2 (en) 2014-02-18 2018-12-04 Advaxis, Inc. Biomarker directed multi-target immunotherapy
KR20160122829A (ko) 2014-02-25 2016-10-24 어드박시스, 인크. Ｈｅｒ2/ｎｅｕ 과발현 종양의 치료를 위한 조성물 및 방법
CA2941405A1 (en) 2014-03-05 2015-09-11 Advaxis, Inc. Methods and compositions for increasing a t-effector cell to regulatory t cell ratio
US20150278441A1 (en) * 2014-03-25 2015-10-01 Nec Laboratories America, Inc. High-order semi-Restricted Boltzmann Machines and Deep Models for accurate peptide-MHC binding prediction
SG11201608820WA (en) 2014-04-24 2016-11-29 Advaxis Inc Recombinant listeria vaccine strains and methods of producing the same
GB201408255D0 (en) 2014-05-09 2014-06-25 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML)
EP2944955A1 (en) 2014-05-13 2015-11-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Benchmark for LC-MS systems
WO2015172843A1 (en) 2014-05-16 2015-11-19 Biontech Diagnostics Gmbh Methods and kits for the diagnosis of cancer
GB201411037D0 (en) 2014-06-20 2014-08-06 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL)
US10000533B2 (en) 2014-06-20 2018-06-19 Immatics Biotechnologies Gmbh Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
WO2016011320A1 (en) 2014-07-18 2016-01-21 Advaxis, Inc. Bivalent listeria-based delivery system of heterologous antigens
CA2955612C (en) 2014-07-18 2022-05-17 Advaxis, Inc. Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
CA2955432A1 (en) 2014-07-18 2016-01-21 Advaxis, Inc. Listeria-based immunogenic compositions for eliciting anti-tumor responses
EP3194970B1 (en) 2014-09-10 2021-07-28 F. Hoffmann-La Roche AG Immunogenic mutant peptide screening platform
EP3193892A4 (en) 2014-09-14 2018-09-12 Washington University Personalized cancer vaccines and methods therefor
ES2895750T3 (es) 2014-09-15 2022-02-22 Abvitro Llc Secuenciación de alto rendimiento de colecciones de nucleótidos
CN107002038B (zh) 2014-09-17 2021-10-15 约翰·霍普金斯大学 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法
CN105524984B (zh) 2014-09-30 2021-04-13 深圳华大基因科技有限公司 预测新抗原表位的方法及设备
JP2017532325A (ja) 2014-10-03 2017-11-02 イエール ユニバーシティ 抗癌療法のための自然免疫系の改変
WO2016062323A1 (en) 2014-10-20 2016-04-28 Biontech Ag Methods and compositions for diagnosis and treatment of cancer
WO2016069282A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Altering gene expression in modified t cells and uses thereof
DE102014116335A1 (de) 2014-11-10 2016-05-12 Thyssenkrupp Ag Verbundwerkstoff, Verbundwerkstoffprodukt, Verfahren zu deren Herstellung und Verwendungen dafür
MA40737A (fr) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
MA41218A (fr) 2014-12-19 2017-10-24 Advaxis Inc Combinaison de vaccin à base de listeria comportant des anticorps anti-ox40 ou anti-gitr
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
EP3623386B1 (en) 2015-01-08 2022-04-13 BioNTech SE Agonistic tnf receptor binding agents
NL2014108B1 (en) 2015-01-09 2016-09-30 Aduro Biotech Holdings Europe B V Altered april binding antibodies.
WO2016126876A2 (en) 2015-02-03 2016-08-11 Advaxis, Inc. Listeria-based adjuvants
US20160220652A1 (en) 2015-02-03 2016-08-04 Advaxis, Inc. Methods of using recombinant listeria vaccine strains in disease immunotherapy
CA2975027A1 (en) 2015-02-09 2016-08-18 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Means and methods for minimizing swept and dead volumes in chromatographic applications
WO2016128060A1 (en) 2015-02-12 2016-08-18 Biontech Ag Predicting t cell epitopes useful for vaccination
WO2016131875A1 (en) 2015-02-17 2016-08-25 Biontech Diagnostics Gmbh Methods and kits for the molecular subtyping of bladder cancer
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
EP3267969A1 (en) 2015-03-09 2018-01-17 King's College London Combination therapy with rar alpha agonists for enhancing th1 response
WO2016145578A1 (en) 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
GB201504502D0 (en) 2015-03-17 2015-04-29 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers
WO2016154412A2 (en) 2015-03-26 2016-09-29 The Trustees Of The University Of Pennsylvania Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
GB201505585D0 (en) 2015-03-31 2015-05-13 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers
WO2016155809A1 (en) 2015-03-31 2016-10-06 Biontech Rna Pharmaceuticals Gmbh Lipid particle formulations for delivery of rna and water-soluble therapeutically effective compounds to a target cell
UY36616A (es) 2015-04-13 2016-10-31 Aduro Biotech Inc Fusiones de variante iii del receptor de factor de crecimiento epidérmico-mesotelina y métodos para usar los mismos
JP2018512165A (ja) 2015-04-13 2018-05-17 アデュロ バイオテック，インコーポレイテッド 癌の治療のための免疫原性融合タンパク質
WO2016172624A1 (en) 2015-04-22 2016-10-27 Agenus Inc. Methods for treating cancer
GB201507030D0 (en) 2015-04-24 2015-06-10 Immatics Biotechnologies Gmbh Immunotherapy against lung cancers, in particular NSCLC
CN107750278B (zh) 2015-04-27 2023-10-03 癌症研究技术有限公司 治疗癌症的方法
GB201507719D0 (en) 2015-05-06 2015-06-17 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
CA2984794A1 (en) 2015-05-07 2016-11-10 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
WO2016180467A1 (en) 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
WO2016183361A1 (en) 2015-05-13 2016-11-17 Advaxis, Inc. Immunogenic listeria-based compositions comprising truncated acta-antigen fusions and methods of use thereof
SG10201912485PA (en) 2015-05-13 2020-02-27 Agenus Inc Vaccines for treatment and prevention of cancer
TW202523682A (zh) 2015-05-20 2025-06-16 美商博德研究所有限公司 共有之gata3相關之腫瘤特異性新抗原
US10293637B2 (en) 2015-05-21 2019-05-21 Burley Design Llc Bicycle quick release cam lever with biased closure
EP3302574A4 (en) 2015-05-26 2018-10-17 Advaxis, Inc. Personalized delivery vector-based immunotherapy and uses thereof
MA44594B1 (fr) 2015-05-29 2020-09-30 Memorial Sloan Kettering Cancer Center Anticorps anti-ctla-4 et méthodes d'utilisation de ceux-ci
GB201510771D0 (en) 2015-06-19 2015-08-05 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer
KR20180027501A (ko) 2015-06-24 2018-03-14 어드박시스, 인크. 맞춤형 전달 벡터-기반 면역 요법을 위한 제조 장치 및 공정
GB201511191D0 (en) 2015-06-25 2015-08-12 Immatics Biotechnologies Gmbh T-cell epitopes for the immunotherapy of myeloma
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
GB201511792D0 (en) 2015-07-06 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers
EP3115369A1 (en) 2015-07-09 2017-01-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Peptide purification using mixed-phase solid phase extraction material
GB201512369D0 (en) 2015-07-15 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
CN107848956A (zh) 2015-07-29 2018-03-27 马克斯-普朗克科学促进学会 用于样品制备尤其是用于质谱分析的方式和方法
WO2017024006A1 (en) 2015-08-03 2017-02-09 The Johns Hopkins University Personalized, allogeneic cell therapy of cancer
GB201513921D0 (en) 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
WO2017030956A1 (en) 2015-08-14 2017-02-23 Agenus Inc. Method of inducing a t-cell response to phosphopeptides using nucleic acids encoding phosphopeptide mimetics
GB201515321D0 (en) 2015-08-28 2015-10-14 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
US10130693B2 (en) 2015-08-28 2018-11-20 Immatics Biotechnologies Gmbh Peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
CN114605548A (zh) 2015-09-01 2022-06-10 艾吉纳斯公司 抗-pd-1抗体及其使用方法
AU2016339924B2 (en) 2015-10-12 2020-01-02 Nantomics, Llc Compositions and methods for viral cancer neoepitopes
US10546650B2 (en) * 2015-10-23 2020-01-28 Google Llc Neural network for processing aptamer data
JP2019506143A (ja) 2015-12-14 2019-03-07 ベリカム ファーマシューティカルズ， インコーポレイテッド 治療用細胞の活性化及び排除のための二重コントロール
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
US10497089B2 (en) * 2016-01-29 2019-12-03 Fotonation Limited Convolutional neural network
EP3446119A1 (en) * 2016-04-18 2019-02-27 The Broad Institute Inc. Improved hla epitope prediction
PE20191345A1 (es) 2016-11-23 2019-09-30 Gritstone Oncology Inc Administracion viral de neoantigenos
KR20180063481A (ko) 2016-12-02 2018-06-12 주식회사 원소프트다임 체지방을 측정하는 클라우드 기반 휴대용 장치를 이용하여 헬스케어 정보를 제공하는 방법 및 이를 이용하는 장치
JP7155470B2 (ja) * 2017-03-31 2022-10-19 エーシーティー ジェノミックス （アイピー） カンパニー リミテッド 免疫原性がん特異的エピトープのためのランク付けシステム
KR102841050B1 (ko) 2017-04-19 2025-08-01 그릿스톤 바이오, 인코포레이티드 신생항원 동정, 제조, 및 용도
CN110720127A (zh) 2017-06-09 2020-01-21 磨石肿瘤生物技术公司 新抗原的鉴别、制造及使用
JP7763588B2 (ja) 2017-09-05 2025-11-04 グリットストーン バイオ インコーポレイテッド Ｔ細胞療法用の新生抗原の特定法
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
CN119851752A (zh) 2018-02-27 2025-04-18 磨石生物公司 利用泛等位基因模型进行的新抗原鉴别

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103415534A (zh) * 2009-03-10 2013-11-27 贝勒研究院 靶向抗原呈递细胞的癌症疫苗
CN103180730A (zh) * 2010-05-14 2013-06-26 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法
CN103180730B (zh) * 2010-05-14 2016-03-02 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANISH SURI: "Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition", 《PNAS》 *
EDWARD F. FRITSCH: "HLA-Binding Properties of Tumor Neoepitopes in Humans", 《CANCER IMMUNOLOGY MINIATURES》 *
POLYAKOVA A.: "Proteogenomics meets cancer immunology: Mass spectrometric discovery and analysis of neoantigens", 《EXPERT REVIEW OF PROTEOMICS》 *
RAJASAGI M.: ""Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia", 《 BLOOD》 *
SCHUMACHER T. N.: "Neoantigens in cancer immunotherapy", 《SCIENCE》 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113424264B (zh) * 2018-11-15 2024-04-12 Nouscom股份公司 用于生成个性化癌症疫苗的癌症突变选择
CN113424264A (zh) * 2018-11-15 2021-09-21 Nouscom股份公司 用于生成个性化癌症疫苗的癌症突变选择
CN113474840A (zh) * 2018-12-21 2021-10-01 百欧恩泰美国公司 用于预测hla ii类特异性表位及表征cd4+ t细胞的方法和系统
CN109706065A (zh) * 2018-12-29 2019-05-03 深圳裕策生物科技有限公司 肿瘤新生抗原负荷检测装置及存储介质
CN110675913B (zh) * 2019-01-16 2022-04-12 倍而达药业（苏州）有限公司 一种基于hla分型与结构的肿瘤新抗原的筛选方法
CN110675913A (zh) * 2019-01-16 2020-01-10 倍而达药业（苏州）有限公司 一种基于hla分型与结构的肿瘤新抗原的筛选方法
CN109801678A (zh) * 2019-01-25 2019-05-24 上海鲸舟基因科技有限公司 基于全转录组的肿瘤抗原预测方法及其应用
CN113412519A (zh) * 2019-02-11 2021-09-17 旗舰开拓创新六世公司 机器学习引导的多肽分析
CN113412519B (zh) * 2019-02-11 2024-05-21 旗舰开拓创新六世公司 机器学习引导的多肽分析
CN111621564B (zh) * 2019-02-28 2022-03-25 武汉大学 一种鉴定有效肿瘤新抗原的方法
CN111621564A (zh) * 2019-02-28 2020-09-04 武汉大学 一种鉴定有效肿瘤新抗原的方法
CN113316818B (zh) * 2019-03-15 2024-04-02 痕准生物医学技术(厦门)有限公司 新生抗原的鉴定方法
CN113316818A (zh) * 2019-03-15 2021-08-27 痕准生物科技有限公司 新生抗原的鉴定方法
CN110172513A (zh) * 2019-05-30 2019-08-27 浙江自贸区锐赛生物医药科技有限公司 突变型免疫多肽临床入组的筛选方法
CN110706747A (zh) * 2019-09-17 2020-01-17 北京橡鑫生物科技有限公司 检测肿瘤新生抗原多肽的方法和装置
CN110706747B (zh) * 2019-09-17 2021-09-07 北京橡鑫生物科技有限公司 检测肿瘤新生抗原多肽的方法和装置
CN110456079A (zh) * 2019-09-20 2019-11-15 四川大学华西医院 Tapbp自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN111303268A (zh) * 2020-03-10 2020-06-19 江苏兰恩生物治疗技术研究院有限公司 子宫肌瘤新抗原、其应用和子宫肌瘤疫苗
CN113807468A (zh) * 2021-10-15 2021-12-17 南京澄实生物科技有限公司 基于多模态深度编码的hla抗原呈递预测方法和系统
CN113807468B (zh) * 2021-10-15 2022-05-27 南京澄实生物科技有限公司 基于多模态深度编码的hla抗原呈递预测方法和系统
CN120877859A (zh) * 2025-07-10 2025-10-31 北京深势科技有限公司 一种基于自由能变进行突变位点筛选的处理方法和装置

Also Published As

Publication number Publication date
PE20181535A1 (es) 2018-09-26
KR102883915B1 (ko) 2025-11-18
US20210166784A1 (en) 2021-06-03
SG11201804957VA (en) 2018-07-30
EP4299136A2 (en) 2024-01-03
JP2025065197A (ja) 2025-04-17
CN119905147A (zh) 2025-04-29
ES2970865T3 (es) 2024-05-31
US10847252B2 (en) 2020-11-24
IL259931A (en) 2018-07-31
CA3008641A1 (en) 2017-06-22
WO2017106638A1 (en) 2017-06-22
AU2023204618B2 (en) 2026-02-12
IL305238B1 (en) 2025-09-01
MX2023014124A (es) 2023-12-12
US10847253B2 (en) 2020-11-24
JP7114477B2 (ja) 2022-08-08
KR20180107102A (ko) 2018-10-01
US20170212984A1 (en) 2017-07-27
TW201733598A (zh) 2017-10-01
RU2018124997A (ru) 2020-01-16
RU2018124997A3 (https=) 2020-05-29
US20180330055A1 (en) 2018-11-15
IL305238B2 (en) 2026-01-01
AU2016369519B2 (en) 2023-04-20
MX2018007204A (es) 2018-12-11
AU2023204618A1 (en) 2023-08-03
PH12018501267A1 (en) 2019-02-11
CO2018007417A2 (es) 2018-09-28
IL322399A (en) 2025-09-01
IL305238A (en) 2023-10-01
JP2022133271A (ja) 2022-09-13
BR112018012374A2 (pt) 2018-12-04
TWI765875B (zh) 2022-06-01
KR20250164855A (ko) 2025-11-25
US20190065675A1 (en) 2019-02-28
HK1257865A1 (en) 2019-11-01
US10055540B2 (en) 2018-08-21
US20210098077A1 (en) 2021-04-01
US11183286B2 (en) 2021-11-23
EP4299136A3 (en) 2024-02-14
AU2016369519A1 (en) 2018-07-12
IL259931B2 (en) 2024-02-01
RU2729116C2 (ru) 2020-08-04
US20190034585A1 (en) 2019-01-31
EP3389630A4 (en) 2020-01-01
JP2019501967A (ja) 2019-01-24
EP3389630B1 (en) 2023-11-08
EP3389630A1 (en) 2018-10-24
IL259931B1 (en) 2023-10-01
US20170199961A1 (en) 2017-07-13

Similar Documents

Publication Publication Date Title
US11183286B2 (en) Neoantigen identification, manufacture, and use
US20250316334A1 (en) Neoantigen identification, manufacture, and use
EP3635594B1 (en) Neoantigen identification, manufacture, and use
CN111630602A (zh) 减少新抗原的接合表位呈递
HK40123114A (en) Neoantigen identification, manufacture, and use
HK40027511A (en) Neoantigen identification, manufacture, and use
HK40027511B (en) Neoantigen identification, manufacture, and use
HK1257865B (en) Neoantigen identification, manufacture, and use

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: California, USA

Applicant after: Millstone biological Co.

Address before: California, USA

Applicant before: Gritstone Oncology, Inc.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180928