CN108497099A - Fullerene be used to be prepared into the purposes of fullerene microcapsule powder - Google Patents
Fullerene be used to be prepared into the purposes of fullerene microcapsule powder Download PDFInfo
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- CN108497099A CN108497099A CN201810259287.8A CN201810259287A CN108497099A CN 108497099 A CN108497099 A CN 108497099A CN 201810259287 A CN201810259287 A CN 201810259287A CN 108497099 A CN108497099 A CN 108497099A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
- A23D7/04—Working-up
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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Abstract
The invention discloses the purposes that fullerene be used to be prepared into fullerene microcapsule powder, the fullerene microcapsule powder that is prepared, which has, improves oxidation resistance, and/or improves immunity, and/or can pre- anti-cancer, delay neurodegenerative disease, and/or the purposes relieved the effect of alcohol.It can be taken in a manner of food simultaneously, it is more flexible various in mouthfeel and absorption mode.It is made into microcapsule powder and is greatly improved its application field.
Description
Technical field
The present invention relates to the use that fullerene field more particularly to a kind of fullerene be used to be prepared into fullerene microcapsule powder
On the way.
Background technology
Fullerene is a kind of Spectra of Carbon Clusters being made of 60 carbon atoms, is the allotrope of graphite, diamond.It can
Affine free radical has extremely strong oxidation resistance.Fullerene is because having the bioactivity such as antiviral, anti-oxidant, antibacterial, at me
Be widely used in daily life and social production, such as cosmetics, pharmaceutical carrier, medical diagnosis various fields.2011
French Fathi Moussa research groups are published in the article on Biomaterials and disclose their great discovery：By C60
It is distributed to feeding mouse after olive oil, it is found that C60 does not have chronic toxicity, the service life of mouse can be made to extend 90% or more.
To in the research of these neurodegenerative diseases caused by the deposition of amyloid fiber such as senile dementia, parkinsonism
, it was also found that fullerene can effectively prevent the formation of amyloid fiber.To the research of liver cancer, it was also found that pass through be injected intraperitoneally it is rich
It strangles alkene soluble derivative with anticarcinogen CTX, cisplatin to compare, find after having injected fullerene derivate, tumour is big
It is big to inhibit, and concentration increases effect and also promoted, in an amount of from CTX 1/500 when effect and CTX it is suitable；Richness is compared with cisplatin
The effect for strangling ene derivative is better.
Microcapsules technology is a kind of technology that solid or liquid are coated with filmogen and to form fine particle.Grease micro-capsule
Powder is to develop a kind of very fast raw-food material in recent years, the good characteristic with common grease, is capable of providing energy, improves
Flavour of food products and mouthfeel；Unlike, microcapsule powder can overcome the application drawback of conventional grease, such as prevent certain unstable foods
The oxidation of product supplementary material is gone bad.On storage stability, by grease little particle be embedded dosage form at film wrapped up, therefore have
Have and is not easy rancid thermal stability.Fullerene is not soluble in water, limits its development and application.In fullerene utilization, mainly will
Water-soluble derivative is made in fullerene, is such as hydrated fullerene, Fullerol, fullerene-vitamin C, metal fullerene etc.；Right
The treatment of liver cancer, kidney, neurodegenerative disease etc. has outstanding behaviours.So it is preferably and flexible to be badly in need of exploitation fullerene
Purposes.
Invention content
The purpose of the present invention is to provide the purposes that fullerene be used to be prepared into fullerene microcapsule powder.
To achieve the above object, the present invention provides the purposes that a kind of fullerene be used to be prepared into fullerene microcapsule powder.
Further, the fullerene includes C60 and its derivative, C70 and its derivative, fullerene metal derivative, richness
Strangle alkene oil solution.
Further, the fullerene microcapsule powder contains fullerene, nutrition compounding oil, food emulsifier and wall material.
Further, the weight consumption of the fullerene is 1 ‰ -5 ‰.
Further, the weight consumption of the nutrition compounding oil is 50%-70%；
Optional, the dosage of the food emulsifier is the 4-6% of the fat weight content in nutrition compounding oil；It is preferred that
, the dosage of food emulsifier is the 5% of fat weight content；
Optional, the wall material weight consumption is 29%-49%.
Further, the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：Mostly not
Saturated fatty acid is 1:(0.5~2):(0.5~2), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~
2)；
Preferably, the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：How unsaturated
Aliphatic acid is 1:(0.5~1.5):(0.5~1.5), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~
1.5)；
It is furthermore preferred that the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：More insatiable hungers
It is 1 with aliphatic acid:1:1, wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:1.
Further, nutrition compounding oil be linseed oil, safflower seed oil, Purple Perilla Seed Oil, camellia seed oil, sunflower oil,
Soybean oil, olive oil, pumpkin seed oil, evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, peony seed oil, walnut oil, text
It is preced with fruit oil, Seabuckthorn Oil, fiery sesame oil, linoleic acid, leukotrienes, linoleic acid triglyceride, conjugated linoleic acid, conjugated linoleic acid glycerine three
Two or more combinations in ester.
Further, the food emulsifier is the mixture of A or A and B；Wherein A is oligomeric maltose, maltodextrin, consolidates
1 kind in body corn syrup, oligofructose, resistant dextrin, skimmed milk power or 2 kinds；B is casein sodium, list, diglycerine fatty
Acid esters, starch Sodium Octenyl Succinate, ascorbic acid, sodium ascorbate, gelatin, polydextrose, phosphatide, natural VE, three
One kind in polyphosphate sodium, Arabic gum and ascorbyl palmitate；
Optional, the wall material is soybean protein isolate, xanthans, converted starch, gelatin, carboxymethyl cellulose, malt
2 kinds or 3 kinds or more in dextrin mix.
Further, the preparation method of the microcapsule powder is,
It is prepared by oil phase：Nutrition compounding oil is prepared by fatty acid proportion, nutrition compounding is dissolved into after then fullerene sterilizes
In oil, at the oily compound of compounding；Food emulsifier is dissolved into the oily compound of compounding, oil phase is obtained；
It is prepared by water phase：Wall material is dissolved in hot water and obtains water phase；Preferably, the temperature of hot water is 60-80 DEG C；Wherein temperature
Less than 60 DEG C dissolvings are incomplete, and temperature is easily destroyed active ingredient higher than 80 DEG C；
Mixing sterilizing：Gained water phase is mixed evenly with oil phase, is then sterilized；
Homogeneous, spraying, drying：Homogeneous sprays, is dried to obtain fullerene microcapsule powder.
Further, the microcapsule powder have improve oxidation resistance, and/or improve immunity, and/or can pre- anti-cancer, prolong
Delay neurodegenerative disease, and/or the purposes relieved the effect of alcohol.
Fullerene can not be all dissolved in grease, and additive amount increases not directly proportional to solubility.If dissolving is special
It is few, it is simple in technique, it is at low cost, but the microcapsule powder taken in will increase accordingly, the oil quantity taken in accordingly just will increase,
Human nutriology's requirement is not met；If the amount of dissolving is high, complex process, technical difficulty is big, and the cost of fullerene can increase
Very much.Applicant had found when the additive amount of fullerene of the present invention is 1 ‰ -5 ‰ by extremely hard and bitter labour, can be with
It is dissolved with simple agitating mode；When additive amount is more than 5 ‰, stirring can not all dissolve, and undissolved fullerene will pass through
Centrifugal treating comes out, and the bad cleaning of remaining fullerene.Simultaneously by the experiment in terms of its effect, finding fullerene intake
Amount is 8mg/ days/people, so that it may to show significant antioxidant effect.
When the additive amount of nutrition compounding oil is less than 50%, contained nutritional ingredient grease is just few, poor taste；When
When the additive amount of nutrition compounding oil is higher than 70%, grease is easy broken wall, and embedding effect is bad, can influence to brew, the micro-capsule of production
Powder is easy caking, conglomeration.
Nutrition of the present invention compounding oil is linseed oil, safflower seed oil, Purple Perilla Seed Oil, camellia seed oil, sunflower oil, big
Soya-bean oil, olive oil, pumpkin seed oil, evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, peony seed oil, walnut oil, Wen Guan
2 in fruit oil, fiery sesame oil, linoleic acid, leukotrienes, linoleic acid triglyceride, conjugated linoleic acid, conjugated linoleic acid triglyceride etc.
It plants or 3 kinds or more is compounded by fatty acid proportion.
Wall material is 2 kinds in soybean protein isolate, xanthans, converted starch, gelatin, carboxymethyl cellulose, maltodextrin
Or 3 kinds or more mix.
The food emulsifier is the mixture of A or A and B；Wherein A is oligomeric maltose, maltodextrin, corn in solids
1 kind in syrup, oligofructose, resistant dextrin, skimmed milk power or 2 kinds；B be casein sodium, list, diglycerine fatty acid ester,
Starch Sodium Octenyl Succinate, ascorbic acid, sodium ascorbate, polydextrose, phosphatide, natural VE, sodium tripolyphosphate,
2 kinds or 3 kinds or more in Arabic gum, ascorbyl palmitate mix.The dosage of food emulsifier is usually fat
5% or so of content, compound use can reach microcapsule powder stability height, and the laxity of good water solubility, microcapsule powder is good, is not easy to tie
Block, conglomeration comparatively ideal effect.
It can be taken in a manner of food after microcapsule powder is made in fullerene, it is more flexible more in mouthfeel and absorption mode
Sample.It is made into microcapsule powder and is greatly improved its application field.Fullerene microcapsule powder of the present invention uses raw-food material for packet
Material is wrapped up in, the various nourishing beverage of instant edible, flavor is transformed into, can be short-term or be taken for a long time, there is anti-aging, inhibit
The health-care efficacy of cancer has high promotional value.
Specific implementation mode
The embodiment of the present invention is described below in detail, the examples of the embodiments are intended to be used to explain the present invention, and cannot
It is interpreted as limitation of the present invention.In the examples where no specific technique or condition is specified, according to described by document in the art
Technology or condition or carried out according to product description.Reagents or instruments used without specified manufacturer is that can lead to
Cross the conventional products of acquisition purchased in market.
A kind of fullerene be used to be prepared into the purposes of fullerene microcapsule powder.
Further, the fullerene includes C60 and its derivative, C70 and its derivative, fullerene metal derivative, richness
Strangle alkene oil solution.
Further, the fullerene microcapsule powder contains fullerene, nutrition compounding oil, food emulsifier and wall material.
Further, the weight consumption of the fullerene is 1 ‰ -5 ‰.
Further, the weight consumption of the nutrition compounding oil is 50%-70%；
Optional, the dosage of the food emulsifier is the 4-6% of the fat weight content in nutrition compounding oil；It is preferred that
, the dosage of food emulsifier is the 5% of fat weight content；
Optional, the wall material weight consumption is 29%-49%.
Further, the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：Mostly not
Saturated fatty acid is 1:(0.5~2):(0.5~2), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~
2)；
Preferably, the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：How unsaturated
Aliphatic acid is 1:(0.5~1.5):(0.5~1.5), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~
1.5)；
It is furthermore preferred that the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：More insatiable hungers
It is 1 with aliphatic acid:1:1, wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:1.
Further, nutrition compounding oil be linseed oil, safflower seed oil, Purple Perilla Seed Oil, camellia seed oil, sunflower oil,
Soybean oil, olive oil, pumpkin seed oil, evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, peony seed oil, walnut oil, text
It is preced with fruit oil, Seabuckthorn Oil, fiery sesame oil, linoleic acid, leukotrienes, linoleic acid triglyceride, conjugated linoleic acid, conjugated linoleic acid glycerine three
Two or more combinations in ester.
Further, the food emulsifier is the mixture of A or A and B；Wherein A is oligomeric maltose, maltodextrin, consolidates
1 kind in body corn syrup, oligofructose, resistant dextrin, skimmed milk power or 2 kinds；B is casein sodium, list, diglycerine fatty
Acid esters, starch Sodium Octenyl Succinate, ascorbic acid, sodium ascorbate, gelatin, polydextrose, phosphatide, natural VE, three
One kind in polyphosphate sodium, Arabic gum and ascorbyl palmitate；
Optional, the wall material is soybean protein isolate, xanthans, converted starch, gelatin, carboxymethyl cellulose, malt
2 kinds or 3 kinds or more in dextrin mix.
Further, the preparation method of the microcapsule powder is,
It is prepared by oil phase：Nutrition compounding oil is prepared by fatty acid proportion, nutrition compounding is dissolved into after then fullerene sterilizes
In oil, at the oily compound of compounding；Food emulsifier is dissolved into the oily compound of compounding, oil phase is obtained；
It is prepared by water phase：Wall material is dissolved in hot water and obtains water phase；Preferably, the temperature of hot water is 60-80 DEG C；
Mixing sterilizing：Gained water phase is mixed evenly with oil phase, is then sterilized；
Homogeneous, spraying, drying：Homogeneous sprays, is dried to obtain fullerene microcapsule powder.
Further, the microcapsule powder have improve oxidation resistance, and/or improve immunity, and/or can pre- anti-cancer, prolong
Delay neurodegenerative disease, and/or the purposes relieved the effect of alcohol.
Embodiment 1：The preparation of fullerene microcapsule powder
Raw material usage (weight percent %) table of 1 embodiment 1- of table
| Sterile fullerene | Emulsifier | Nutrition compounding oil | Wall material | |
| Embodiment 1 | 1‰ | 3.0% | 50% | 46.90% |
| Embodiment 2 | 5‰ | 3.5% | 70% | 26.00% |
| Embodiment 3 | 2.5‰ | 2.5% | 50% | 47.25% |
| Embodiment 4 | 3‰ | 3.0% | 60% | 36.70% |
The manufacture craft of fullerene microcapsule powder includes：
(1) it presses fatty acid proportion and prepares nutrition compounding oil；
(2) it is dissolved into after fullerene sterilizing in nutrition compounding oil, forms the oily compound of compounding；
(3) food emulsifier is dissolved into the oily compound of compounding, obtains oil phase；
(4) wall material is dissolved in 60-80 DEG C of hot water and obtains water phase；
(5) gained water phase is mixed evenly with oil phase, is then sterilized；
(6) homogeneous, spray, be dried to obtain fullerene microcapsule powder.
It is vitamin that the fullerene microcapsule powder being prepared measures its oxidation resistance by external beta carotene oxidizing process
125 times of C.
Embodiment 2：The preparation of fullerene microcapsule powder
Raw material：It is shown in Table 1.
Manufacture craft, with embodiment 1.The fullerene microcapsule powder being prepared is measured by external beta carotene oxidizing process
Its oxidation resistance is ascorbic 125 times.
Embodiment 3：The preparation of fullerene microcapsule powder
Raw material：It is shown in Table 1.
Manufacture craft, with embodiment 1.The fullerene microcapsule powder being prepared is measured by external beta carotene oxidizing process
Its oxidation resistance is ascorbic 125 times.
Embodiment 4：The preparation of fullerene microcapsule powder
Raw material：It is shown in Table 1.
Manufacture craft, with embodiment 1.The fullerene microcapsule powder being prepared is measured by external beta carotene oxidizing process
Its oxidation resistance is ascorbic 125 times.
Embodiment 5：The effect experiment of the raising immunity of fullerene microcapsule powder
Powder or pressure is made in fullerene the microcapsule powder 5g, anthocyanidin 1g, vitamin C 500mg of any gained of embodiment 1-4
Tablet is made, long-term use has the function of improving immunity.
Embodiment 6：Fullerene microcapsule powder is used for the effect experiment of health care
The fullerene microcapsule powder 20g of any gained of embodiment 1-4.One people is once a day eaten in the form of directly brewing for a long time
With, can pre- anti-cancer, delay neurodegenerative disease such as Parkinson, senile dementia etc..Patient reaction's fullerene microcapsule powder simultaneously
More people is allowed to receive than simple fullerene olive oil in mouthfeel and edible way.
Embodiment 7：The disintoxicating product and compliance test result of the microcapsule powder containing fullerene are tested
Fullerene microcapsule powder 2g, pueraria lobata 1g, hoveniae semoveniae semen 1g, Poria cocos 0.25g, the honey 1g of any gained of embodiment 1-4, will
Powder or solid particle is made in it, takes before drinking and is still drank after a night after drinking with alleviation, the symptom for vomiting of having a headache.
It relieves the effect of alcohol experiment：
Product Safety of the present invention measures：
Healthy clean type kunming mice 20 (weight 18-22g), half male and half female, random pair is taken to be divided into two groups, every group 10
Only, administration group：0.33ml/20gBW (10 times that are equivalent to people's dose) (computational methods：People's effective dose 5.25g (presses human body
Weight 65Kg conversions), it is about 0.0165 to be converted into 10 multiple dose of 20g mouse；Disintoxicating product 0.5g is taken to be dissolved in 10ml water, 0.33ml contains
Have 0.0165g, i.e. intragastric administration on mice aequum is 0.33ml/20g), control group：Give 0.33ml/20gBW normal salines.
Two groups are continuously fed 7d, observe mouse growth state and adverse reaction and death condition.Put to death within 8th day mouse, naked eyes and mirror
Lower each internal organs abnormal conditions of observation.Observation result is shown：Mouse does not occur adverse reaction, and each internal organs are also without exception under the microscope
It was found that.
Preliminary experiment：
With reference to related document, with 0.26ml/20g, 0.28ml/20g, 0.30ml/20g, 0.32ml/20g, 0.34ml/
20g, 0.36ml/20g wine solution (56 degree of Red Star strong, colourless liquor distilled from sorghum) carry out gavages to 6 groups of mouse respectively, every group 6.Observation makes mouse
There is righting reflex loss and the required capacity for liquor without dead mouse.Experimental result such as table 2：Select gavage 0.30ml/20g wine solution
Do subsequent experimental.
Influence table of the table 2 to the mouse alcoholism death rate
| Group | Total n | Alcohol (ml/20g) | Dead n (%) | Survival n (%) | Drunk n (%) |
| A | 10 | 0.26 | 0 | 100 | 30 |
| B | 10 | 0.28 | 0 | 100 | 50 |
| C | 10 | 0.30 | 0 | 100 | 100 |
| D | 10 | 0.32 | 20 | 80 | 100 |
| E | 10 | 0.34 | 60 | 40 | 100 |
| F | 10 | 0.36 | 90 | 10 | 100 |
The influence of administration drunk to acute alcoholism mice time, the time of relieving the effect of alcohol and drunk rate：
Mouse is randomly divided into 4 groups：Model group (gavaging isometric(al) physiological saline), low dose group (gavage 0.1ml/20g), in
Dosage group (gavage 0.2ml/20g), high dose (gavage 0.3ml/20g), every group 10.Each group mouse fasting 12h, disposably gives
Medicine.Each group is using 15ml/kg (with preliminary data as foundation) 56 DEG C of Beijing Erguotou wine gavages of weight, observation note after 30min
The mice drunk time (from the time regained consciousness to areflexia anyway) is recorded, the drunk rate in for 24 hours is calculated.Whether mice drunk, with
Whether righting reflex disappears for standard：Mouse fills after drinking by it under, is gently put into mouse cage, if posture of the mouse under is protected
Hold 30s or more, then it is assumed that righting reflex loss, it is as drunk.Mouse is observed and recorded to sober up the time (from righting reflex loss to clear
The awake time), calculate the death rate in for 24 hours.As a result such as table 3-4：As can be seen that the present invention has good dispelling effects of alcohol.
The dose form of 3 different experiments group of table
| Group | Quantity | Dosage (ml/20g) | It is equivalent to human body amount (mg/kg) |
| Control group | 20 | 0.1 | - |
| Low dose group | 20 | 0.04 | 150 |
| Middle dose group | 20 | 0.08 | 300 |
| High dose group | 20 | 0.1 | 450 |
10 points start gavage wine.
Note：Wherein control group administration be to ddH2O。
The result table of the different group gavages of table 4 after drinking
From table 3-4 it is found that low dose group, middle dose group, high dose group and contrast ratio, drunk duration are obviously shortened, and with
The increase of dosage, duration reduces, illustrates to take the disintoxicating product containing microcapsule powder, has apparent rescue effect.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art are not departing from the principle of the present invention and objective
In the case of can make changes, modifications, alterations, and variations to the above described embodiments within the scope of the invention.
Claims (10)
1. fullerene be used to be prepared into the purposes of fullerene microcapsule powder.
2. fullerene as described in claim 1 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the richness
It includes C60 and its derivative, C70 and its derivative, fullerene metal derivative, fullerene oil solution to strangle alkene.
3. fullerene as described in claim 1 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the fowler
Alkene microcapsule powder contains fullerene, nutrition compounding oil, food emulsifier and wall material.
4. fullerene as claimed in claim 3 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the fowler
The weight consumption of alkene is 1 ‰ -5 ‰.
5. fullerene as claimed in claim 3 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the nutrition
The weight consumption of compounding oil is 50%-70%；
Optional, the dosage of the food emulsifier is the 4-6% of the fat weight content in nutrition compounding oil；Preferably, it eats
It is the 5% of fat weight content with the dosage of emulsifier；
Optional, the wall material weight consumption is 29%-49%.
6. fullerene as claimed in claim 3 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the nutrition
The oil fatty acid ratio of compounding oil is saturated fatty acid：Monounsaturated fatty acids：Polyunsaturated fatty acid is 1:(0.5~2):
(0.5~2), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~2)；
Preferably, the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：Polyunsaturated fat
Acid is 1:(0.5~1.5):(0.5~1.5), wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:(0.5~1.5)；
It is furthermore preferred that the oil fatty acid ratio of nutrition compounding oil is saturated fatty acid：Monounsaturated fatty acids：How unsaturated fat
Fat acid is 1:1:1, wherein polyunsaturated fatty acid Linoleic acid：Leukotrienes is 1:1.
7. fullerene as claimed in claim 3 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the nutrition
Compounding oil be linseed oil, safflower seed oil, Purple Perilla Seed Oil, camellia seed oil, sunflower oil, soybean oil, olive oil, pumpkin seed oil,
Evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, peony seed oil, walnut oil, shinyleaf yellowhorn oil, Seabuckthorn Oil, fiery sesame oil, Asia
Two or more combinations in oleic acid, leukotrienes, linoleic acid triglyceride, conjugated linoleic acid, conjugated linoleic acid triglyceride.
8. fullerene as claimed in claim 3 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that described edible
Emulsifier is A or the mixture of A and B；Wherein A is oligomeric maltose, maltodextrin, corn syrup solid, oligofructose, resists
1 kind or 2 kinds in property dextrin, skimmed milk power；B is casein sodium, list, diglycerine fatty acid ester, octenyl succinic acid starch
Sodium, ascorbic acid, sodium ascorbate, gelatin, polydextrose, phosphatide, natural VE, sodium tripolyphosphate, Arabic gum and anti-
One kind in bad hematic acid palmitate；
Optional, the wall material is soybean protein isolate, xanthans, converted starch, gelatin, carboxymethyl cellulose, maltodextrin
In 2 kinds or 3 kinds or more mix.
9. fullerene as described in claim 1 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that the micro-capsule
The preparation method of powder is,
It is prepared by oil phase：Nutrition compounding oil is prepared by fatty acid proportion, is dissolved into after then fullerene sterilizes in nutrition compounding oil,
At the oily compound of compounding；Food emulsifier is dissolved into the oily compound of compounding, oil phase is obtained；
It is prepared by water phase：Wall material is dissolved in 60-80 DEG C of hot water and obtains water phase；Preferably, the temperature of hot water is 60-80 DEG C；
Mixing sterilizing：Gained water phase is mixed evenly with oil phase, is then sterilized；
Homogeneous, spraying, drying：Homogeneous sprays, is dried to obtain fullerene microcapsule powder.
10. fullerene as described in claim 1 be used to be prepared into the purposes of fullerene microcapsule powder, which is characterized in that described micro-
Capsule powder have improve oxidation resistance, and/or improve immunity, and/or can pre- anti-cancer, delay neurodegenerative disease, and/or
The purposes relieved the effect of alcohol.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810259287.8A CN108497099A (en) | 2018-03-27 | 2018-03-27 | Fullerene be used to be prepared into the purposes of fullerene microcapsule powder |
| CN201811123023.6A CN110301483A (en) | 2018-03-27 | 2018-09-26 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN201811365406.4A CN109258931A (en) | 2018-03-27 | 2018-11-16 | Fullerene additive for farm animal feed and preparation method thereof and feed |
| CN201811365697.7A CN109258932A (en) | 2018-03-27 | 2018-11-16 | Fullerene feed for pet additive and preparation method thereof and feed |
| CN201811365700.5A CN109258934A (en) | 2018-03-27 | 2018-11-16 | Application of the fullerene microcapsule powder as feed addictive |
| CN202210449776.6A CN115024365A (en) | 2018-03-27 | 2018-11-16 | Application of fullerene to preparation of fullerene microcapsule powder and preparation method |
| CN201811365699.6A CN109258933A (en) | 2018-03-27 | 2018-11-16 | Fullerene feeding additive aquatic animal and preparation method thereof and feed |
| PCT/CN2018/118812 WO2019184419A1 (en) | 2018-03-27 | 2018-12-03 | Use of fullerene compound, fullerene microcapsule powder and preparation method and application thereof |
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| CN201811123023.6A Pending CN110301483A (en) | 2018-03-27 | 2018-09-26 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN201811365406.4A Pending CN109258931A (en) | 2018-03-27 | 2018-11-16 | Fullerene additive for farm animal feed and preparation method thereof and feed |
| CN201811365697.7A Pending CN109258932A (en) | 2018-03-27 | 2018-11-16 | Fullerene feed for pet additive and preparation method thereof and feed |
| CN201811365699.6A Pending CN109258933A (en) | 2018-03-27 | 2018-11-16 | Fullerene feeding additive aquatic animal and preparation method thereof and feed |
| CN201811365700.5A Pending CN109258934A (en) | 2018-03-27 | 2018-11-16 | Application of the fullerene microcapsule powder as feed addictive |
| CN202210449776.6A Pending CN115024365A (en) | 2018-03-27 | 2018-11-16 | Application of fullerene to preparation of fullerene microcapsule powder and preparation method |
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| CN201811365406.4A Pending CN109258931A (en) | 2018-03-27 | 2018-11-16 | Fullerene additive for farm animal feed and preparation method thereof and feed |
| CN201811365697.7A Pending CN109258932A (en) | 2018-03-27 | 2018-11-16 | Fullerene feed for pet additive and preparation method thereof and feed |
| CN201811365699.6A Pending CN109258933A (en) | 2018-03-27 | 2018-11-16 | Fullerene feeding additive aquatic animal and preparation method thereof and feed |
| CN201811365700.5A Pending CN109258934A (en) | 2018-03-27 | 2018-11-16 | Application of the fullerene microcapsule powder as feed addictive |
| CN202210449776.6A Pending CN115024365A (en) | 2018-03-27 | 2018-11-16 | Application of fullerene to preparation of fullerene microcapsule powder and preparation method |
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- 2018-11-16 CN CN201811365697.7A patent/CN109258932A/en active Pending
- 2018-11-16 CN CN201811365699.6A patent/CN109258933A/en active Pending
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Also Published As
| Publication number | Publication date |
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| CN109258931A (en) | 2019-01-25 |
| CN115024365A (en) | 2022-09-09 |
| CN110301483A (en) | 2019-10-08 |
| CN109258934A (en) | 2019-01-25 |
| CN109258932A (en) | 2019-01-25 |
| CN109258933A (en) | 2019-01-25 |
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