CN107048405A - Aliphatic acid component microcapsules and preparation method thereof - Google Patents
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Abstract
The present invention relates to a kind of aliphatic acid component microcapsules and preparation method thereof, belong to food and medicine field.It is made up of the crude oil and auxiliary material of fatty acids, the auxiliary material is made up of wall material, antioxidant and emulsifying agent；The mass ratio of the crude oil is 30 50%, and wall material content is 34 60%, and oxidation preventive content is 2 10%, and emulsifier content is 6%.The present invention is by palmitic acid (PA), oleic acid (OA), linoleic acid (LA), alpha linolenic acid, eicosapentaenoic acid (EPA), water-soluble fabulous microcapsules are made in docosahexaenoic acid (DHA), it can not only directly take after mixing it with water, and nose can be carried out to clinical patient and watch and pipe is watched, so as to improve bio-digestion rate, absorptivity and biological value.
Description
Technical field
The present invention relates to a kind of aliphatic acid component microcapsules and preparation method thereof, belong to food and medicine field.
Background technology
Dietary fat is one of main nutrients of human body, is divided into saturated fatty acid according to the saturation degree of its fatty acid carbon chain
(Saturated fatty acid, SFA), monounsaturated fatty acids (Monounsaturated fatty acid, MUFA) and
Polyunsaturated fatty acid (Polyunsaturated fatty acid, PUFA) three types, wherein polyunsaturated fatty acid lead to
Often include two classes：N-6PUFA and the classes of n-3PUFA two.
Saturated fatty acid (SFA) such as palmitic acid (Palmitic acid, PA, C16:0) be butterfat in human milk and cow's milk master
Want constituent.Modern study shows that palmitic acid has reduction serum cholesterol levels, promotes infant's intestinal health etc. to make
With (Chen Yinji, Ju Xingrong, the grand saturated fatty acids classification of period-luminosity and physiological function [J] Chinese oils, 2008,33 (3):35-
39).Monounsaturated fatty acids (MUFA), such as oleic acid, with reduction blood glucose and low density cholesterol content, regulation blood fat, prevention
The effect such as atherosclerosis (functional characteristic [J] the Chinese foods of Wang Wei, Zhang Weimin monounsaturated fatty acids and nutrition,
2005(4)：44-46)
N-6PUFA includes linoleic acid (linoleic acid, LA, C18:2) and arachidonic acid (arachidoic acid,
ARA,C20:4).Linoleic acid is topmost n-6PUFA in meals, is the essential fatty acid that human body itself can not be synthesized, therefore must
It must be absorbed from food.Linoleic acid has radioresistance, reduction cholesterol and artery sclerosis, enhancing development, and enhancing body is exempted from
The different physiological roles such as epidemic disease power and cosmetology, and the hormonal substance played an important role in linoleic acid or metabolic process
The precursor of prostaglandin.Human body, which lacks linoleic acid, can cause sensitiveness (Xu Shenggeng, fur coat of erythrosis, increase dehydration and infection
Love swimming shellfish thunders：Oil chemistry and technology China Light Industry Press).Relevant research shows, as linoleic intake ＞
2.5%E, ARA can meet body needs by linoleic acid, occur without the relevant issues of ARA shortages.
N-3PUFA includes alpha-linolenic acid (α-linolenic acid, ALA, C18:3), eicosapentaenoic acid
(eicosapentaenoic acid, EPA, C20:5), docosahexaenoic acid (docosahexaenoic acid, DHA,
C22:6).N-3PUFA, which has, promotes retina, brain and nervous system development, antitumor and inflammatory reaction and reduction coronary heart disease,
(Wang Lihua, Huo Gui are into .n-3 unsaturated fats for the special role of the incidences of disease such as hypertension, atherosclerosis, type-II diabetes
Biological action [J] the Northeast Agricultural Universities journal of acid, 2001,32 (1):100-104).Alpha-linolenic acid is primarily present in plant
In oil；EPA and DHA contents in general plant are little, and in abyssal fishes content compared with horn of plenty.Alpha-linolenic acid is EPA and DHA
Precursor, human body itself can not synthesize EPA and DHA, but alpha-linolenic acid can be converted into EPA and DHA.
Too low essential fatty acid insufficiency of intake, the fat soluble vitamin absorption of producing of dietary fat intake is asked using reduction etc.
Topic, but dietary fat intake can excessively increase triglycerides in blood (TG), cholesterol (TC) and LDL-C
(LDL-C) concentration, increases a variety of chronic pathogenetic danger such as cardiovascular and cerebrovascular disease, cancer.Aliphatic acid is that dietary fat is most heavy
There is very big difference in the constituent wanted, influence of different types of dietary fatty acid to health.Therefore crowd's dietary fatty acid
Intake and its food source are received more and more attention.
Balanced fatty acid is the important dietary factors for maintaining health, is the World Health Organization (WHO) and the United Nations's grain
The important content for the dietary nutrition of urban residents guide that agriculture tissue (FAO) and various countries are worked out, many countries, area or tissue have been formulated
The Dietary reference intakes of dietary fat and aliphatic acid." Chinese DRIs expert's Chinese Soclety of Nutrition in 2000 entrusts
Member's meeting " combines China's resident's meals composition and aliphatic acid intake reality is proposed, in meals 20%~30% premise of total fatty energy supply
Under, saturated fatty acid (SFA), monounsaturated fatty acids (MUFA), the energy supply of polyunsaturated fatty acid (PUFA) they are respectively ＜
10%th, ＞ 10% and 10%, i.e., 1: 1: 1；Wherein n-6 and n-3 suitable ratio is (4~6): 1 (in Chinese Soclety of Nutrition
State's dietary nutrition of urban residents element Dietary reference intakes [M] Beijing:China Light Industry Press, 2000).
Due to the raising recognized aliphatic acid health benefits, the dietary supplements such as fish oil and linseed oil have caught on.
At present, in order to cover the disagreeable taste of the greases such as fish oil and linseed oil and improve its stability, commercially available fish oil and linseed oil etc.
Dietary supplements mainly exist with capsule form, and this has just limited to the universal adaptability of the dietary supplements such as fish oil and linseed oil,
Especially to the crowd of dysphagia.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of water-soluble aliphatic acid component microcapsules and its preparation side
Method.
A kind of water-soluble aliphatic acid component microcapsules, are made up of the crude oil and auxiliary material of fatty acids, the auxiliary material by wall material,
Antioxidant and emulsifying agent composition；The mass ratio of the crude oil is 30-50%, and wall material content is 34-60%, and antioxidant contains
Measure as 2-10%, emulsifier content is 6%；
The crude oil is by palmitic acid (PA), oleic acid (OA), linoleic acid (LA), alpha-linolenic acid (ALA), docosahexaenoic acid
(DHA) constituted with eicosapentaenoic acid (EPA), palmitic acid (PA)：Oleic acid (OA)：Linoleic acid (LA)：Alpha-linolenic acid (ALA)：Two
The mass ratio of dodecahexaene acid (DHA)+eicosapentaenoic acid (EPA) is (0-21)：(10-47)：(7-48)：(0.75-8)：
1, wherein n-6PUFA：N-3PUFA mass ratioes are (4-6)：1, crude oil is deposited with free fatty, methyl esters, ethyl ester or glyceride form
.
Source and quality purity on crude oil, further details are：
Palmitic acid (PA) derives from palm oil, its content >=65wt%；
Oleic acid (OA) derives from camellia seed oil, olive oil, its content >=60%；
Linoleic acid (LA) derives from sunflower oil, safflower oil or grape-kernel oil, its content >=50%；
Alpha-linolenic acid (ALA) derives from linseed oil or Purple Perilla Seed Oil, its content >=45%；
When docosahexaenoic acid used (DHA) and eicosapentaenoic acid (EPA) derive from fish oil, two dodecahexaenes
Sour (DHA)+eicosapentaenoic acid (EPA) content >=23%；When docosahexaenoic acid used (DHA) crude oil origin is in algae oil
When, docosahexaenoic acid (DHA) content >=40%.
The aliphatic acid component microcapsules are in addition to crude oil, also following auxiliary material composition：Wall material, antioxidant, emulsifying agent,
Wherein wall material is selected from modified starch, hydroxypropyl-β-cyclodextrin, Arabic gum, gelatin, chitosan, casein sodium, whey egg
In vain, soybean protein, gliadin, methylcellulose, HPMC, maltodextrin, glucose syrup, glucose, sea
One or more in algae sugar, lactose, sucrose, corn syrup；It is sweet that the emulsifying agent is selected from glycerin monostearate, mono laurate
One or more in grease, sucrose ester, tween, sapn, lecithin；The antioxidant is selected from lecithin, vitamin E, fan
Repeatedly fragrant extract, Tea Polyphenols, tea polyphenol-palmitate, cinnamic acid, ascorbic acid, sodium ascorbate, ascorbyl palmitate
In one or more.
A kind of preparation method of above-mentioned water-soluble aliphatic acid component microcapsules, comprises the following steps：
1) it is added to the water after in an inert atmosphere, wall material, Partial Antioxidation agent, emulsifying agent are mixed, keeps water temperature
Dissolved in 25 DEG C of -75 DEG C of stirrings to complete mix within 20-60 minutes, aqueous phase is made；
2) in an inert atmosphere, by crude oil and remaining antioxidant at 25 DEG C -40 DEG C of temperature it is miscible, oil is made
Phase；
3) in an inert atmosphere, by step 2) gained oil phase add step 1) gained aqueous phase in mixture, with height
Fast cutter carries out high speed shear to mixture with 2000r/min-7800r/min speed, and shear time is 8-50 minutes, breast
Change forms colostric fluid；
4) twice homogenization, first time homogeneous in an inert atmosphere, are carried out to the colostric fluid using high pressure homogenizer
Pressure is 15-50MPa, and second of homogenization pressure is 35-85MPa；
5) step 4 is kept) gained emulsion temperature is 30-65 DEG C, it is made after conventional mixing, sterilization and spray drying
Aliphatic acid component microcapsules.
The EAT of the spray drying is 150-220 DEG C, and leaving air temp is 85-105 DEG C.
Particle diameter≤800nm of prepared aliphatic acid component microcapsules；Fuel load is 30-50%, with good aqueous solubility.
The present invention is by palmitic acid (PA), oleic acid (OA), linoleic acid (LA), alpha-linolenic acid, eicosapentaenoic acid (EPA), two
Water-soluble fabulous microcapsules are made in dodecahexaene acid (DHA), can not only directly take after mixing it with water, and clinical patient can be carried out
Nose is watched and pipe is watched, so as to improve bio-digestion rate, absorptivity and biological value.
Embodiment
Embodiment one
3.89 kilograms of casein sodiums, 5.89 kilograms of maltodextrins, 1.08 kilograms of sucrose esters, 0.36 kilogram of sodium ascorbate
Added after mixing in 32.0 kilograms of pure water, maintain water temperature at 55 DEG C of stirrings and mix dissolving to complete in 55 minutes, aqueous phase is made standby；
All operations are carried out in an inert atmosphere.
Weigh 1.30 kilogram of 68.5% palmitic acid, 2.19 kilogram of 99.2% oleic acid, 2.33 kilogram of 90% linoleic acid, 0.41 public affairs
85% alpha-linolenic acid of jin, 0.07 kilogram of fish oil (wherein DHA+EPA content >=80%) mixing is given birth to as crude oil and 0.48 kilogram of dimension
Plain E is miscible at 35 DEG C of temperature, oil phase is made standby；All operations are carried out in an inert atmosphere.
By step 2) gained oil phase be slowly added to step 1) gained aqueous phase in mixture, with high-speed shearing machine with 7000r/
Min speed carries out high speed shear to mixture, and shear time is 25min, and emulsification forms colostric fluid；All operations are in inertia
Carried out under gaseous environment.
Twice homogenization is carried out to the colostric fluid using high pressure homogenizer, first time homogenization pressure is 25MPa, and second
Matter pressure is 55MPa；All operations are carried out in an inert atmosphere.
Keeping step 4) gained emulsion temperature is 55 DEG C and fat is made by conventional mixing, sterilization and drying process with atomizing
Sour microscapsule powder, the EAT of the spray drying is maintained at 195 DEG C, and leaving air temp is maintained at 90 DEG C~97 DEG C；Bottom of towe
The pulverulent solids drawn as fatty acid microcapsule；Microcapsules oil content 35%, it is 92.8% to survey embedding rate, epigranular,
Granularity is 675-752nm.
Embodiment two
Weigh 6.29 kilograms of Arabic gums, 4.82 kilograms of glucose syrups, 4.98 kilograms of maltodextrins, 0.40 kilogram of single tristearin
Acid glyceride, 1.61 kilograms of sucrose esters, 0.5 kilogram of sodium ascorbate is added in 46.56 kilograms of pure water after mixing, and is maintained water temperature at
70 DEG C of stirrings mix dissolving in 60 minutes to complete, aqueous phase are made standby；All operations are carried out in an inert atmosphere.
Weigh 2.51 kilogram of 72.4% palm oil, 4.72 kilogram of 90.7% oleic acid, 5.96 kilogram of 85% linoleic acid, 0.96 public affairs
80.8% alpha-linolenic acid of jin, 0.16 kilogram of algae oil mixing is used as crude oil and 0.20 kilogram of ascorbyl palmitate and 0.33 kilogram
Lecithin is miscible at 25 DEG C of temperature, oil phase is made standby；All operations are carried out in an inert atmosphere.
By step 2) gained oil phase be slowly added to step 1) gained aqueous phase in mixture, with high-speed shearing machine with 5500r/
Min speed carries out high speed shear to mixture, and shear time is 45min, and emulsification forms colostric fluid；All operations are in inertia
Carried out under gaseous environment.
Twice homogenization is carried out to the colostric fluid using high pressure homogenizer, first time homogenization pressure is 40MPa, and second
Matter pressure is 80MPa；All operations are carried out in an inert atmosphere.
Keeping step 4) gained emulsion temperature is 50 DEG C and fat is made by conventional mixing, sterilization and drying process with atomizing
Sour microscapsule powder, the EAT of the spray drying is maintained at 185 DEG C, and leaving air temp is maintained at 85 DEG C~90 DEG C；Bottom of towe
The pulverulent solids drawn as fatty acid microcapsule；Microcapsules oil content 42.8%, it is 97.3% to survey embedding rate, and granularity is equal
Even, granularity is 541-679nm.
Claims (8)
1. a kind of water-soluble aliphatic acid component microcapsules, are made up of the crude oil and auxiliary material of fatty acids, the auxiliary material is by wall material, anti-
Oxidant and emulsifying agent composition；The mass ratio of the crude oil is 30-50%, and wall material content is 34-60%, oxidation preventive content
For 2-10%, emulsifier content is 6%；
The crude oil is made up of palmitic acid, oleic acid, linoleic acid, alpha-linolenic acid, docosahexaenoic acid and eicosapentaenoic acid, palm fibre
Palmitic acid acid：Oleic acid：Linoleic acid：Alpha-linolenic acid：The mass ratio of docosahexaenoic acid+eicosapentaenoic acid is (0-21)：(10-
47)：(7-48)：(0.75-8)：1, wherein n-6PUFA：N-3PUFA mass ratioes are (4-6)：1, crude oil is with free fatty, first
Ester, ethyl ester or glyceride form are present.
2. water-soluble aliphatic acid component microcapsules according to claim 1, it is characterised in that：
Palmitic acid origin is in palm oil, its content >=65wt%；
Oleic acid derives from camellia seed oil, olive oil, its content >=60wt%；
Linoleic acid sources are in sunflower oil, safflower oil or grape-kernel oil, its content >=50wt%；
Alpha-linolenic acid derives from linseed oil or Purple Perilla Seed Oil, its content >=45wt%；
When docosahexaenoic acid used and eicosapentaenoic acid derive from fish oil, docosahexaenoic acid+eicosapentaenoic
Acid content >=23wt%；When docosahexaenoic acid crude oil origin used is in algae oil, docosahexaenoic acid content >=
40wt%.
3. water-soluble aliphatic acid component microcapsules according to claim 1, it is characterised in that：Wherein wall material is selected from modified form sediment
Powder, hydroxypropyl-β-cyclodextrin, Arabic gum, gelatin, chitosan, casein sodium, lactalbumin, soybean protein, the molten egg of wheat alcohol
In vain, methylcellulose, HPMC, maltodextrin, glucose syrup, glucose, trehalose, lactose, sucrose, primverose
One or more in slurry.
4. water-soluble aliphatic acid component microcapsules according to claim 1, it is characterised in that：The emulsifying agent is selected from single hard
One or more in glycerol, glyceryl monolaurate, sucrose ester, tween, sapn, lecithin.
5. water-soluble aliphatic acid component microcapsules according to claim 1, it is characterised in that：The antioxidant is selected from ovum
It is phosphatide, vitamin E, Rosmarinus officinalis extract, Tea Polyphenols, tea polyphenol-palmitate, cinnamic acid, ascorbic acid, sodium ascorbate, anti-
One or more in bad hematic acid palmitate.
6. the preparation method of the water-soluble aliphatic acid component microcapsules described in claim 1, comprises the following steps：
1) it is added to the water after in an inert atmosphere, wall material, Partial Antioxidation agent, emulsifying agent are mixed, maintains water temperature at 25
DEG C of -75 DEG C stirrings mix dissolving, obtained aqueous phase in 20-60 minute to complete；
2) in an inert atmosphere, by crude oil and remaining antioxidant at 25 DEG C -40 DEG C of temperature it is miscible, oil phase is made；
3) in an inert atmosphere, by step 2) gained oil phase add step 1) gained aqueous phase in mixture, with high speed cut
Cut machine and high speed shear is carried out to mixture with 2000r/min-7800r/min speed, shear time is 8-50 minutes, emulsifies shape
Into colostric fluid；
4) twice homogenization, first time homogenization pressure in an inert atmosphere, are carried out to the colostric fluid using high pressure homogenizer
For 15-50MPa, second of homogenization pressure is 35-85MPa；
5) step 4 is kept) gained emulsion temperature is 30-65 DEG C, and aliphatic acid component is made after mixing, sterilization and spray drying
Microcapsules.
7. preparation method according to claim 6, it is characterised in that the EAT of the spray drying is 150-220
DEG C, leaving air temp is 85-105 DEG C.
8. the preparation method according to claim 6 or 7, particle diameter≤800nm of prepared aliphatic acid component microcapsules.
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Application publication date: 20170818 |