CN114617264A - Plant capsule preparation with high content of EPA - Google Patents

Plant capsule preparation with high content of EPA Download PDF

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Publication number
CN114617264A
CN114617264A CN202011467722.XA CN202011467722A CN114617264A CN 114617264 A CN114617264 A CN 114617264A CN 202011467722 A CN202011467722 A CN 202011467722A CN 114617264 A CN114617264 A CN 114617264A
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preparation
capsule
functional
water
starch
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Chinese (zh)
Inventor
俞威
吴小莉
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Shenzhen Qianhai Xiaozao Tech Co ltd
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Shenzhen Qianhai Xiaozao Tech Co ltd
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Priority to CN202011467722.XA priority Critical patent/CN114617264A/en
Priority to PCT/CN2021/104927 priority patent/WO2022127083A1/en
Publication of CN114617264A publication Critical patent/CN114617264A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present disclosure describes a plant capsule preparation with high content of EPA comprising a functional preparation and a capsule shell encasing the functional preparation; the functional preparation comprises more than 95 percent of EPA and/or EPA alkyl ester by mass percent; the capsule shell is of a sealed structure and insoluble in a functional preparation, the capsule shell is made of a first formula or a second formula, the first formula comprises a film forming material, a humectant and water, the mass ratio of the film forming material to the humectant to the water is 1: 0.2-0.5: 1-1.4, the second formula comprises hydroxypropyl starch, vegetable gum, a plasticizer and water, the mass percentage of the hydroxypropyl starch is 21% -27%, the mass percentage of the vegetable gum is 11% -13%, the mass percentage of the plasticizer is 19% -29%, the mass percentage of the water is 35% -45%, the capsule shell is a plant capsule shell, and the water content of the capsule shell is 8% -12%. According to the present disclosure, a plant capsule preparation having a high content of EPA with good stability can be provided.

Description

Plant capsule preparation with high content of EPA
Technical Field
The present disclosure relates to a plant capsule preparation having a high content of EPA.
Background
It is known that eicosapentaenoic acid (EPA) is a nutrient essential for human life, and has effects of lowering blood triglyceride level, lowering risk of cardiovascular disease, and the like, and when EPA is deficient, it is liable to suffer from diseases such as hyperlipidemia, cardiovascular disease, blood stroke, hypertension, and the like, but human body cannot synthesize EPA by itself, and it is necessary to take it from outside and supplement it, so high-purity EPA oil can be widely used in medicines and health foods.
The high-purity EPA oil is extremely sensitive to light, temperature, air and the like, is extremely easy to oxidize and loses the physiological function and the nutritional value, the traditional EPA oil is generally encapsulated in a gelatin-containing capsule shell, the EPA oil is unstable in the storage process, gelatin mainly comes from bones and skins of animals such as pigs, cows and the like, the problems of risk of spreading mad cow disease, excessive heavy metal and preservative and the like exist, and the high-purity EPA oil is not accepted by special culturists or vegetarians.
Disclosure of Invention
The present disclosure has been made in view of the above-mentioned state of the art, and an object thereof is to provide a plant capsule preparation having high content of EPA with good stability.
To this end, the present disclosure provides a plant capsule preparation with high content of EPA, which includes a functional preparation with probiotic effect and a capsule shell enclosing the functional preparation; the functional preparation comprises more than 95 percent of eicosapentaenoic acid (EPA) and/or eicosapentaenoic acid alkyl ester (EPA alkyl ester) formed by esterification of EPA by mass percent; the capsule shell is of a sealing structure and insoluble in the functional preparation, and is made of a first formula or a second formula, wherein the first formula comprises a film forming material, a humectant and water, the mass ratio of the film forming material to the humectant to the water is 1: 0.2-0.5: 1-1.4, the second formula comprises hydroxypropyl starch, vegetable gum, a plasticizer and water, the mass percentage of the hydroxypropyl starch is 21-27%, the mass percentage of the vegetable gum is 11-13%, the mass percentage of the plasticizer is 19-29%, the mass percentage of the water is 35-45%, the capsule shell is a plant capsule shell, and the water content of the capsule shell is 8-12%. In the disclosure, the functional preparation contains more than 95% of EPA and/or EPA alkyl ester, and is encapsulated by a capsule shell which is prepared from a specific formulation and is beneficial to storing the functional preparation, so that the influence of external factors on the functional preparation can be effectively prevented or prevented, the oxidation of the functional preparation is weakened, and the plant capsule preparation has good stability.
In addition, in the plant capsule preparation according to the present disclosure, optionally, the film-forming material is at least one selected from tapioca starch, carrageenan, guar gum, and xanthan gum, and the humectant is at least one selected from glycerin, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, and sorbitol. Thereby, the preparation of the capsule shell can be facilitated.
Additionally, in the botanical capsule formulation contemplated by the present disclosure, optionally, the capsule shell is made from a first formulation consisting of tapioca starch, glycerin and water. Therefore, the capsule shell which is beneficial to the storage of the functional preparation can be formed, thereby being beneficial to the improvement of the stability of the plant capsule preparation.
In addition, in the plant capsule preparation according to the present disclosure, optionally, the plant gum is at least one selected from carrageenan, gellan gum, gum arabic and guar gum, the hydroxypropyl starch is at least one selected from hydroxypropylated mung bean starch, wheat starch, potato starch, tapioca starch, soybean starch and corn starch, and the plasticizer is at least one selected from glycerin, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol and sorbitol.
Additionally, in the plant capsule formulation to which the present disclosure relates, optionally, the capsule shell is made of a second formulation consisting of hydroxypropylated tapioca starch, carrageenan, glycerin and water. Therefore, the capsule shell which is beneficial to the storage of the functional preparation can be formed, thereby being beneficial to the improvement of the stability of the plant capsule preparation.
In addition, in the plant capsule preparation related to the present disclosure, optionally, the plant capsule preparation is a holothurian preparation, and the functional preparation is derived from microalgae selected from at least one of nannochloropsis, porphyridium, chaetoceros, phaeodactylum tricornutum, spirulina, and tetraselmis.
In addition, in the plant capsule formulation according to the present disclosure, optionally, the initial value of the peroxide value of the functional formulation is less than 5meq/kg, and the peroxide value of the functional formulation is less than 8meq/kg after 12 to 24 months of the plant capsule formulation under an environment of 25 ℃ and 60% RH. Therefore, the oxidation of the functional preparation can be favorably slowed down, and the stability of the plant capsule preparation is improved.
In addition, in the plant capsule preparation related to the present disclosure, optionally, the capsule shell has a thickness of 0.1mm to 1mm, and the functional preparation has a weight of 0.2g to 1.2 g. In this case, it is possible to provide an effective dose of EPA while maintaining the capsule form and avoiding an excessively long disintegration time.
In addition, in the plant capsule preparation related to the present disclosure, optionally, the plant capsule preparation includes an additive added to the functional preparation, and the additive is one or more of an antioxidant, an essence, and a pigment. Therefore, special requirements on plant capsule preparations under different application scenes can be met.
In addition, in the plant capsule preparation related to the present disclosure, optionally, the functional preparation comprises one or more of palmitic acid or a derivative thereof, palmitoleic acid or a derivative thereof, oleic acid or a derivative thereof, linoleic acid or a derivative thereof, linolenic acid or a derivative thereof, stearidonic acid or a derivative thereof, eicosatrienoic acid or a derivative thereof, eicosatetraenoic acid or a derivative thereof, and eicosapentaenoic acid or a derivative thereof. In this case, the effect of the plant capsule preparation can be improved by compounding various ingredients in the functional preparation.
According to the present disclosure, a plant capsule preparation having a high content of EPA with good stability can be provided.
Drawings
Embodiments of the disclosure will now be explained in further detail by way of example with reference to the accompanying drawings,
wherein:
fig. 1 is a schematic diagram illustrating the structure of a plant capsule formulation to which examples of the present disclosure relate.
Fig. 2 is a schematic structural view illustrating a combined capsule housing according to another example of the present disclosure.
Detailed Description
The present disclosure will be described in further detail below with reference to the accompanying drawings and specific embodiments. In the drawings, the same components or components having the same functions are denoted by the same reference numerals, and redundant description thereof will be omitted.
The plant capsule preparation 1 having a high content of EPA according to the present embodiment (hereinafter referred to as "plant capsule preparation 1"). In some examples, the botanical capsule formulation 1 may be made of a whole vegetarian material suitable for receipt, ingestion, by a particular culturist or vegetarian.
The plant capsule preparation 1 according to the present embodiment can be used as a therapeutic drug or a nutritional supplement. In some examples, the plant capsule formulation 1 may be applied to the treatment or prevention of cardiovascular-related diseases. In other examples, the plant capsule preparation 1 can reduce plasma triglyceride levels and platelet aggregation rates, improve inflammation and oxidative stress, and improve hemodynamic functions, thereby being applicable to the treatment or prevention of cardiovascular-related diseases.
In some examples, the cardiovascular-related disease can be acute myocardial infarction, angina pectoris, arrhythmia, atherosclerosis, cardiac insufficiency, chronic heart failure, coronary heart disease, deep vein thrombosis, type II diabetes, essential hypertension, homozygous family sitosterolemia, hypercholesterolemia, hyperlipidemia in an aids virus-positive subject, hypertension, and the like.
The plant capsule preparation 1 according to the present embodiment may include a content and a shell. Wherein the contents may be enclosed by the shell. In some examples, the plant capsule formulation 1 may be rugby-ball shaped (see fig. 1), columnar shaped, or the like. In addition, the contents may be in a solid state (e.g., powder) or a liquid state. Furthermore, both the contents and the enclosure may be made of materials of non-animal origin.
In some examples, the unsaturated fatty acid may be present in the content in an amount of 95% by mass or more. For example, eicosapentaenoic acid (EPA) and/or EPA derivatives (e.g. EPA alkyl esters) may comprise more than 95% mass percent of the contents.
In some examples, the initial value of the peroxide value of the contents may be less than 5 meq/kg. This can contribute to the reduction of the oxidation of the content and the improvement of the stability of the plant capsule preparation 1. For example, the peroxide value of the contents may be set to an initial value of 5meq/kg, 4meq/kg, 3meq/kg, 2meq/kg, 1meq/kg or 0.5 meq/kg.
Fig. 1 is a schematic diagram showing a structure of a plant capsule preparation 1 according to an example of the present disclosure.
In some examples, the contents may include the functional agent 10. Further in some examples, the contents may be the functional agent 10 and the shell may be the capsule shell 20. In addition, in some examples, as shown in fig. 1, the plant capsule formulation 1 may include a functional formulation 10 and a capsule housing 20. Wherein, the functional preparation 10 can be a therapeutic substance or a nutrient substance, and the capsule shell 20 can wrap the functional preparation 10 (see fig. 1). Further, as shown in fig. 1, the plant capsule formulation 1 may be a sealed structure.
As described above, the plant capsule preparation 1 may be formed by wrapping the functional preparation 10 in the capsule housing 20. In some examples, the plant capsule formulation 1 may be made of a holo-material, for example the plant capsule formulation 1 may be encapsulated by a plant capsule shell around the non-animal derived functional formulation 10.
In some examples, the functional agent 10 may be in a liquid state at room temperature. In other examples, the functional agent 10 may be in a solid state (e.g., a powder) at room temperature.
In some examples, the functional preparation 10 may include a fatty acid, and the fatty acid may include an unsaturated fatty acid, for example, EPA and/or an EPA alkyl ester. In other examples, the initial value of the peroxide value of the functional formulation 10 may be less than 5 meq/kg. Therefore, the oxidation of the functional preparation 10 can be favorably slowed down, and the stability of the plant capsule preparation 1 can be improved.
In some examples, the fatty acids may contain high levels of unsaturated fatty acids. In other examples, the unsaturated fatty acids (e.g., EPA and/or EPA alkyl esters) may comprise greater than 95% by mass of the fatty acids.
In some examples, the functional agent 10 may be a fatty acid oil. Specifically, the functional preparation 10 may be a fatty acid oil containing a high content of unsaturated fatty acids. For example, the functional agent 10 may be a fatty acid oil having an unsaturated fatty acid content of 95% or more.
In some examples, the functional preparation 10 may be a fatty acid oil containing a high content of eicosapentaenoic acid (EPA) and/or EPA derivatives formed from EPA. For example, the functional agent 10 may be a fatty acid oil containing a high content of eicosapentaenoic acid (EPA) and/or an eicosapentaenoic acid alkyl ester (EPA alkyl ester) formed by esterification of EPA. Additionally, in some examples, the functional agent 10 may be a fatty acid oil with a weight percentage of EPA and/or EPA alkyl ester above 95%.
In some examples, the weight percent of EPA and/or EPA alkyl ester in functional formulation 10 is above 95%. For example, EPA and/or EPA alkyl ester may comprise 1095%, 96%, 97%, 98%, 99% or 100% mass percent of the functional agent.
In some examples, in the functional preparation 10, the fatty acid may include other fatty acids selected from one or more of palmitic acid or a derivative thereof, palmitoleic acid or a derivative thereof, oleic acid or a derivative thereof, linoleic acid or a derivative thereof, linolenic acid or a derivative thereof, stearidonic acid or a derivative thereof, eicosatrienoic acid or a derivative thereof, eicosatetraenoic acid or a derivative thereof, and eicosapentaenoic acid or a derivative thereof. That is, the functional agent 10 may contain one or more of palmitic acid or a derivative thereof, palmitoleic acid or a derivative thereof, oleic acid or a derivative thereof, linoleic acid or a derivative thereof, linolenic acid or a derivative thereof, stearidonic acid or a derivative thereof, eicosatrienoic acid or a derivative thereof, eicosatetraenoic acid or a derivative thereof, and eicosapentaenoic acid or a derivative thereof. In this case, the effect of the plant capsule preparation can be improved by compounding various ingredients in the functional preparation.
In some examples, the mass percentage of other fatty acids in the functional formulation 10 does not exceed 5%. For example, the mass percentage of the other fatty acids may be 5%, 4.5%, 4%, 3%, 2%, 1%, 0.5%, or 0.
In some examples, the functional formulation 10 may be of non-animal origin. Therefore, the oxidation resistance of the functional preparation 10 can be improved, and the problems that the functional preparation 10 contains heavy metals and has fishy smell can be avoided. For example, the functional preparation 10 may be derived from a plant or fermented by yeast. In other examples, the functional preparation 10 may be of animal origin, such as fish oil.
In some examples, the functional agent 10 may be derived from microalgae. That is, the functional preparation 10 may be obtained by extraction and purification from microalgae.
In some examples, the microalgae may be selected from EPA-rich algae. Thus, the non-animal-derived functional preparation 10 containing a high content of EPA can be obtained. For example, the microalgae may be selected from at least one of nannochloropsis, porphyridium, chaetoceros, phaeodactylum tricornutum, spirulina, and tetraselmis. In some examples, the microalgae can be nannochloropsis sp and the high EPA-containing fatty acid oil is obtained with corresponding cultivation, extraction and purification techniques.
The capsule shell 20 may be made of food grade material. In some embodiments, the capsule housing 20 may be a plant capsule housing.
In other examples, capsule housing 20 may not be soluble in functional formulation 10. Additionally, in some examples, the capsule housing 20 may be a soft capsule housing 20 or a hard capsule housing 20.
In some examples, capsule housing 20 may be a sealing structure. Thereby, the functional preparation 10 can be encapsulated. Additionally, in some examples, the capsule housing 20 may be integrally formed. In other examples, capsule housing 20 may have stitching (i.e., seams).
In some examples, the capsule housing 20 may be formed as a sealed structure through a seaming process. In addition, the sewing thread may be a seam formed by a seam process.
Fig. 2 is a schematic structural view illustrating a combined capsule housing 20' according to another example of the present disclosure.
In some examples, the capsule housing 20 may be a modular capsule housing 20' (see fig. 2). In other examples, as shown in fig. 2, the combined capsule housing 20' may be divided into a first capsule housing 20' a and a second capsule housing 20' b. In addition, the first capsule housing 20'a and the second capsule housing 20' b may be combined by screw engagement, adhesion, or the like to form the capsule housing 20.
In some examples, capsule housing 20 may have an internal cavity. In addition, the functional preparation 10 may be filled in the inner cavity of the capsule housing 20.
In some examples, capsule housing 20 may be made of a first formulation or a second formulation. For example, the capsule housing 20 may be made from a first formulation. Additionally, in some examples, the first formulation may include a film-forming material, a humectant, and water.
In some examples, the first formulation may be comprised of a film-forming material, a humectant, and water. In other words, the capsule housing 20 may be made of a film-forming material, a humectant, and water.
In some examples, the mass ratio of the film-forming material, humectant and water in the first formulation can be 1: 0.2 to 0.5: 1 to 1.4. This can contribute to improving the sealing performance of the capsule case 20. That is, in the first formulation, the mass ratio of the film-forming material to the humectant may be 1: 0.2 to 1: 0.5, and the mass ratio of the film-forming material to water may be 1: 1 to 1: 1.4.
In some examples, the mass ratio of film-forming material, humectant and water in the first formulation can be 1: 0.2: 1, 1: 0.3: 1.15, 1: 0.3: 1.2, 1: 0.4: 1.2, 1: 0.25: 1.3 or 1: 0.5: 1.4.
In some examples, the mass ratio of film-forming material to humectant in the first formulation can be 1: 0.2, 1: 0.25, 1: 0.3, 1: 0.35, 1: 0.4, 1: 0.45 or 1: 0.5. In other examples, the first formulation can comprise a ratio of film formation material to water of 1: 1, 1: 1.5, 1: 2, 1: 2.5, 1: 3, 1: 35 or 1: 1.4.
In some examples, in the first formulation, the film-forming material, humectant and water may preferably be present in a mass ratio of 1: 0.3 to 0.4: 1.15 to 1.2.
In some examples, the film-forming material may be selected from hydrophilic materials of plant origin. For example, the film forming material may be at least one of tapioca starch, carrageenan, guar gum, xanthan gum. Additionally, in some examples, the film-forming material may be mung bean starch, wheat starch, potato starch, soybean starch, or corn starch.
In some examples, the humectant may be selected from at least one of glycerin, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol. Thereby, the drying of the capsule housing 20 can be effectively slowed down. In addition, the water may be purified water.
In some examples, as described above, the film forming material may be at least one selected from tapioca starch, carrageenan, guar gum, xanthan gum, and the humectant may be at least one selected from glycerin, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol. Thereby, the preparation of the capsule housing 20 can be facilitated.
In some examples, the first formulation may include tapioca starch, glycerin, and water. In other examples, the first formulation may be composed of tapioca, glycerin, and water. Thereby, the capsule case 20 advantageous for the preservation of the functional preparation can be formed, thereby being advantageous for the improvement of the stability of the plant capsule preparation 1.
In some examples, capsule shell 20 may be made of tapioca starch, glycerin, and water. In some examples, the mass ratio of tapioca starch, glycerol and water is 1: 0.2-0.5: 1-1.4.
In some examples, in the first formulation, the mass ratio of tapioca starch, glycerol and water is preferably 1: 0.3-0.4: 1.15-1.2. In this case, the capsule shell 20 more advantageous for storing the functional preparation 10 can be formed, so that the stability of the plant capsule preparation 1 can be further improved.
In some examples, the capsule housing 20 may be 0.1mm to 1mm thick. Thus, not only the capsule form can be maintained, but also an excessively long disintegration time can be avoided. For example, the thickness of the capsule housing 20 may be 0.1mm, 0.15mm, 0.2mm, 0.25mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, or 1 mm.
In some examples, the first formulation may include an adjuvant. In other examples, capsule housing 20 may be made of a film-forming material, a humectant, an adjuvant, and water.
In some examples, the amount of adjuvant may not exceed 15% in the first formulation. For example, the amount of adjuvant may be 15%, 14%, 13%, 12%, 11%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1% or 0.
In some examples, the auxiliary materials can be selected according to actual needs, and the auxiliary materials can be selected from one or more of opacifier, essence, flavoring agent and pigment.
In some examples, the opacifying agent may be titanium white, iron oxide, or carbon black, the fragrance may be a food grade fruit-flavored fragrance, the flavoring agent may be sucrose, fructose, glucose, maltose, or aspartame, and the color may be curcumin, carotene, carmine, chlorophyll, brilliant blue, or anthocyanins.
As described above, the capsule housing 20 may be made of the second formulation. In some examples, the second formulation may include hydroxypropyl starch, vegetable gum, a plasticizer, and water.
In some examples, the second formulation may consist of hydroxypropyl starch, vegetable gum, plasticizer, and water. In other words, the capsule shell 20 may be made of hydroxypropyl starch, vegetable gum, plasticizer, and water.
In some examples, the hydroxypropyl starch may be selected from at least one of hydroxypropylated mung bean starch, wheat starch, potato starch, tapioca starch, soybean starch, corn starch. In this case, the hydroxypropyl starch having a good film-forming property can improve the properties (e.g., sealing property, stability, oxidation resistance, etc.) of the capsule shell 20, which can contribute to the improvement of the stability of the plant capsule preparation 1.
In some examples, the hydroxypropyl content of the hydroxypropyl starch may be 1% to 15%. For example, the hydroxypropyl content of the hydroxypropyl starch may be 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% or 15%.
In some examples, the vegetable gum may be selected from at least one of carrageenan, gellan gum, gum arabic, guar gum. Thereby, the molding of the capsule housing 2 can be facilitated. For example, the vegetable gum may be carrageenan.
In some examples, the plasticizer may be selected from at least one of glycerin, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol. This can increase the plasticity of the capsule shell 20, and make the plant capsule preparation 1 (or the capsule shell 20) less likely to deform. For example, the plasticizer may be glycerol.
In some examples, as described above, the vegetable gum may be selected from at least one of carrageenan, gellan gum, gum arabic, guar gum, the hydroxypropyl starch may be selected from at least one of hydroxypropylated mung bean starch, wheat starch, potato starch, tapioca starch, soybean starch, corn starch, and the plasticizer may be selected from at least one of glycerol, polyethylene glycol, butylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol. Thereby, the preparation of the capsule housing 20 can be facilitated.
In some examples, in the second formulation, the hydroxypropyl starch may be hydroxypropylated tapioca starch, the mass percent of vegetable gum may be carrageenan, and the plasticizer may be glycerin. In other words, the second formulation may consist of hydroxypropylated tapioca starch, carrageenan, glycerin and water. This makes it possible to form the capsule case 20 which is advantageous for the preservation of the functional preparation 10, thereby being advantageous for the improvement of the stability of the plant capsule preparation 1.
In some examples, the hydroxypropyl starch may be 21% to 27% by mass in the second formulation. This enables a better film formation, which is advantageous for forming the capsule shell 20. For example, the hydroxypropyl starch may be present at 21%, 21.5%, 22%, 22.5%, 23%, 24%, 25%, 26% or 27% by mass.
In some examples, the vegetable gum may be present in the second formulation in a mass percentage of 11% to 13%. This contributes to gelation and film formation. For example, the mass percentage of the vegetable gum may be 11%, 11.5%, 12%, 12.5%, or 13%.
In some examples, the mass percent of plasticizer in the second formulation may be 19% to 29%. Thereby, the hardness of the capsule housing 20 can be adjusted to an appropriate degree. For example, the mass percentage of plasticizer may be 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, or 29%.
In some examples, the mass percentage of water in the second formulation may be 35% to 45%. For example, the mass percentage of water may be 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, or 45%. In addition, the water may be purified water.
In some examples, in the second formulation, the hydroxypropyl starch may be 21% to 27% by mass, the vegetable gum may be 11% to 13% by mass, the plasticizer may be 19% to 29% by mass, and the water may be 35% to 45% by mass. In this case, the capsule shell 20 more advantageous for storing the functional preparation 10 can be formed, so that the stability of the plant capsule preparation 1 can be further improved.
In some examples, the second formulation may include an adjuvant. In other examples, capsule shell 20 may be composed of hydroxypropyl starch, vegetable gum, plasticizer, excipients, and water.
In some examples, the mass percentage of the adjuvant in the second formulation may not exceed 15%. For example, the amount of adjuvant may be 15%, 14%, 13%, 12%, 10%, 8%, 6%, 4%, 3%, 2%, 1% or 0.
In some examples, the auxiliary materials can be selected according to actual needs, and the auxiliary materials can be selected from one or more of opacifier, essence, flavoring agent and pigment.
In some examples, the contents may include an additive. In other words, the plant capsule formulation 1 may include an additive. Additionally, in some examples, additives may be added to the functional formulation 10.
In some examples, the mass percentage of the additive in the contents may be 0.01% to 5%. For example, the mass percentage of the additive may be 0.01%, 0.05%, 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, or 5%.
In some examples, the additive may be one or more of an antioxidant, a fragrance, a pigment. Additionally, in some examples, the antioxidant may be selected from at least one of salidroside, vitamin E, tocopherol, tea polyphenol palmitate, ascorbyl palmitate, rosemary, the flavor may be a food grade fruit flavor, and the pigment may be curcumin, carotene, carmine, chlorophyll, brilliant blue, or anthocyanins.
In the present embodiment, the formulation of the capsule shell 20 is designed for the functional preparation 10 (or content) wrapped by the capsule shell 20, which can facilitate the preservation (preservation or storage) of the functional preparation 10 (or content), and can effectively hinder or prevent the interference of external factors, so that the plant capsule preparation 1 has good stability.
In some examples, the effective shelf life of the botanical capsule formulation 1 can be up to more than 12 months. And in preferred embodiments may be up to 24 months to 36 months. That is, the plant capsule formulation 1 may have long-term stability.
In some examples, in the plant capsule formulation 1, the filling rate of the content filling the capsule shell 20 may be more than 99%.
In some examples, the functional formulation 10 may fill the capsule shell 20 at a fill rate greater than 99%. Thereby, it can be facilitated to slow down the oxidation of the functional preparation 10. In other examples, the functional formulation 10 may completely fill the capsule housing 20. Thereby, it can be facilitated to slow down the oxidation of the functional preparation 10.
In some examples, the weight of the contents may be 0.2g to 1.2 g. For example, the weight of the contents may be 0.2g, 0.3g, 0.4g, 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.1g, or 1.2 g.
In some examples, the functional formulation 10 may weigh 0.2g to 1.2 g. Thus, an effective dose of EPA can be provided. For example, the functional agent 10 may have a weight of 0.2g, 0.3g, 0.4g, 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.1g, or 1.2 g.
In some examples, the peroxide value of the contents of the plant capsule formulation 1 may be less than 8meq/kg after 12 to 24 months in an environment of 25 ℃ (temperature) and 60% RH (humidity). For example, the peroxide value of the contents may be 8meq/kg, 7.8meq/kg, 7.5meq/kg, 7.2meq/kg, 7meq/kg, 6.8meq/kg, 6.5meq/kg, 6.2meq/kg, 6meq/kg, 5.8meq/kg, 5.5meq/kg, 5.2meq/kg or 5 meq/kg.
In some examples, the peroxide value of the contents of the plant capsule formulation 1 may be less than 8meq/kg after 12 to 24 months at 30 ℃ and 65% RH. For example, the peroxide value of the contents may be 8meq/kg, 7.8meq/kg, 7.5meq/kg, 7.2meq/kg, 7meq/kg, 6.8meq/kg, 6.5meq/kg, 6.2meq/kg, 6meq/kg, 5.8meq/kg, 5.5meq/kg, 5.2meq/kg or 5 meq/kg.
In some examples, the peroxide value of the functional formulation 10 may be less than 8meq/kg after 12 to 24 months in the plant capsule formulation 1 at 25 ℃ and 60% RH environment. For example, the functional preparation 10 may have a peroxide value of 8meq/kg, 7.8meq/kg, 7.5meq/kg, 7.2meq/kg, 7meq/kg, 6.8meq/kg, 6.5meq/kg, 6.2meq/kg, 6meq/kg, 5.8meq/kg, 5.5meq/kg, 5.2meq/kg, or 5 meq/kg.
In some examples, the peroxide value of the functional preparation 10 may be less than 8meq/kg after 12 to 24 months in the plant capsule preparation 1 under the environment of 30 ℃ and 65% RH. For example, the functional preparation 10 may have a peroxide value of 8meq/kg, 7.8meq/kg, 7.5meq/kg, 7.2meq/kg, 7meq/kg, 6.8meq/kg, 6.5meq/kg, 6.2meq/kg, 6meq/kg, 5.8meq/kg, 5.5meq/kg, 5.2meq/kg, or 5 meq/kg.
In the present embodiment, the functional preparation 10 contains more than 95% EPA and/or EPA alkyl ester, and is encapsulated by the capsule shell 20 which is made of a specific formulation and facilitates the preservation of the functional preparation 10, so that the influence of external factors on the functional preparation 10 can be effectively prevented or prevented, thereby reducing the oxidation of the functional preparation 10 and providing the plant capsule preparation 1 with good stability. That is, the capsule case 20 according to the present embodiment can effectively prevent or inhibit the influence of the external factors on the contents, and the plant capsule preparation 1 can have good stability.
According to the present disclosure, a plant capsule preparation 1 having a high content of EPA with good stability can be provided.
To further illustrate the present disclosure, the plant capsule formulation 1 having a high content of EPA provided by the present disclosure is described in detail below with reference to examples, and the advantageous effects achieved by the present disclosure are fully illustrated with reference to comparative examples.
In the examples and comparative examples, the high EPA-containing fatty acid oil of the functional preparation may be derived from EPA-rich algae, wherein the algae may be nannochloropsis, and the high EPA-containing functional preparation is obtained by a corresponding cultivation, extraction and purification technique, with a detected EPA content of above 97% and an initial peroxide value of 0.5 meq/kg.
[ examples ]
Plant capsule shells of each example were prepared according to the formulation of table 1, the functional preparations were respectively encapsulated in the plant capsule shells of each example to prepare plant capsule preparations, and then stored in an environment of 25 ℃ and 60% RH for 24 months, the plant capsule preparations of each example were respectively observed and the second peroxide values of the functional preparations in the plant capsule preparations of each example were measured, and the measurement results are shown in table 3.
[ comparative example ]
The plant capsule shells of the respective comparative examples were prepared according to the formulation of table 2, the functional preparations were respectively wrapped in the plant capsule shells of the respective comparative examples to prepare plant capsule preparations, and then the plant capsule preparations of the respective comparative examples were respectively observed and the second peroxide values of the functional preparations in the plant capsule preparations of the respective comparative examples were measured after 24 months of storage at 25 ℃ and 60% RH, and the measurement results are shown in table 3.
TABLE 1
Formulation of
Example 1 The mass ratio of cassava starch, glycerol and water is 1: 0.2: 1
Example 2 The mass ratio of tapioca starch, glycerol and water is 1: 0.3: 1.2
Example 3 The mass ratio of xanthan gum, glycerol and water is 1: 0.4: 1.15
Example 4 The mass ratio of cassava starch, glycerol and water is 1: 0.2: 1.4
Example 5 The mass ratio of cassava starch, glycerol and water is 1: 0.5: 1
Example 6 The mass ratio of cassava starch, polyethylene glycol and water is 1: 0.5: 1.4
Example 7 25% hydroxypropylated tapioca starch, 11% carrageenan, 29% glycerin, 35% water
Example 8 25% hydroxypropylated tapioca starch, 13% carrageenan, 25% glycerin, 37% water
Example 9 27% hydroxypropylated tapioca starch, 12% carrageenan, 19% glycerin, 42% water
Example 10 21% hydroxypropylated tapioca starch, 12% carrageenan, 22% glycerin, 45% water
Example 11 25% hydroxypropylated wheat starch, 13% carrageenan, 25% glycerin, 37% water
Example 12 25% hydroxypropylated tapioca starch, 13% gellan gum, 25% glycerin, 37% water
Example 13 25% of hydroxypropylated cassava starch, 13% of carrageenan, 25% of polyethylene glycol and 37% of water
TABLE 2
Formulation of
Comparative example 1 The mass ratio of cassava starch, glycerol and water is 1: 0.1: 1
Comparative example 2 The mass ratio of cassava starch, glycerol and water is 1: 0.6: 1
Comparative example 3 The mass ratio of tapioca starch, glycerol and water is 1: 0.2: 0.9
Comparative example 4 The mass ratio of tapioca starch, glycerol and water is 1: 0.2: 1.5
Comparative example 5 25% hydroxypropylated tapioca starch, 10% carrageenan, 29% glycerin, 36% water
Comparative example 6 25% hydroxypropylated tapioca starch, 11% carrageenan, 30% glycerin, 34% water
Comparative example 7 28% hydroxypropylated tapioca starch, 12% carrageenan, 19% glycerin, 41% water
Comparative example 8 25% hydroxypropylated tapioca starch, 14% carrageenan, 25% glycerin, 36% water
Comparative example 9 21% hydroxypropylated tapioca starch, 12% carrageenan, 21% glycerin, 46% water
Comparative example 10 20% hydroxypropylated tapioca starch, 12% carrageenan, 22% glycerin, 46% water
TABLE 3
Test results
Example 1 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 2 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 3 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 4 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 5 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 6 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 7 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 8 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 9 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 10 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 11 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 12 The appearance is complete, no deformation and adhesion occur, and the second peroxide value is less than 8meq/kg
Example 13 Complete shape and no deformationAnd blocking, the second peroxide value is less than 8meq/kg
Comparative example 1 The capsule has breakage and leakage, and the functional preparation is completely oxidized
Comparative example 2 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 3 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 4 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 5 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 6 The capsule has breakage and leakage, and the functional preparation is completely oxidized
Comparative example 7 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 8 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 9 The capsule is damaged and leaked, and the functional preparation is completely oxidized
Comparative example 10 The capsule is damaged and leaked, and the functional preparation is completely oxidized
As can be seen from table 3, after the plant capsule preparations of each example (example 1 to example 13) were stored at 25 ℃ and 60% RH for 24 months, the plant capsule preparations were intact in appearance and were not deformed, no adhesion occurred between the plant capsule preparations, and the peroxide values of the functional preparations were all less than 8 meq/kg. The plant capsule formulations of the respective examples (examples 1 to 13) thus had good stability.
In contrast, the plant capsule preparations of the respective comparative examples (comparative example 1 to comparative example 10) were subject to capsule breakage, and the functional preparation leaked from the capsule breakage, resulting in complete oxidation of the functional preparation.
While the present disclosure has been described in detail in connection with the drawings and the examples, it should be understood that the above description is not intended to limit the scope of the present disclosure in any way. Those skilled in the art can make modifications and variations to the present disclosure as needed without departing from the true spirit and scope of the disclosure, which fall within the scope of the disclosure.

Claims (10)

1. A plant capsule preparation with high EPA content is characterized by comprising a functional preparation with probiotic effect and a capsule shell for wrapping the functional preparation; the functional preparation comprises more than 95% by mass of eicosapentaenoic acid (EPA) and/or eicosapentaenoic acid alkyl ester (EPA alkyl ester) formed by esterification of EPA; the capsule shell is of a sealing structure and insoluble in the functional preparation, and is made of a first formula or a second formula, wherein the first formula comprises a film forming material, a humectant and water, the mass ratio of the film forming material to the humectant to the water is 1: 0.2-0.5: 1-1.4, the second formula comprises hydroxypropyl starch, vegetable gum, a plasticizer and water, the mass percentage of the hydroxypropyl starch is 21-27%, the mass percentage of the vegetable gum is 11-13%, the mass percentage of the plasticizer is 19-29%, the mass percentage of the water is 35-45%, the capsule shell is a plant capsule shell, and the water content of the capsule shell is 8-12%.
2. The plant capsule formulation of claim 1,
the film forming material is at least one selected from tapioca starch, carrageenan, guar gum and xanthan gum, and the humectant is at least one selected from glycerol, polyethylene glycol, butanediol, propylene glycol, hexanediol, xylitol, polypropylene glycol and sorbitol.
3. The plant capsule formulation of claim 1 or 2,
the capsule shell is made from a first formulation consisting of tapioca starch, glycerin and water.
4. The plant capsule formulation of claim 1,
the vegetable gum is selected from at least one of carrageenan, gellan gum, gum arabic and guar gum, the hydroxypropyl starch is selected from at least one of hydroxypropylated mung bean starch, wheat starch, potato starch, tapioca starch, soybean starch and corn starch, and the plasticizer is selected from at least one of glycerol, polyethylene glycol, butanediol, propylene glycol, hexanediol, xylitol, polypropylene glycol and sorbitol.
5. The plant capsule formulation of claim 1 or 4,
the capsule shell is made of a second formula, and the second formula consists of hydroxypropylated cassava starch, carrageenan, glycerol and water.
6. The plant capsule formulation of claim 1,
the plant capsule preparation is a holothurian preparation, the functional preparation is derived from microalgae, and the microalgae is selected from at least one of nannochloropsis sp, porphyridium sp, chaetoceros sp, phaeodactylum tricornutum sp, spirulina sp and Platymonas sp.
7. The plant capsule formulation of claim 1 or 6,
the initial value of the peroxide value of the functional preparation is less than 5meq/kg, and the peroxide value of the plant capsule preparation is less than 8meq/kg after 12 to 24 months under the environment of 25 ℃ and 60% RH.
8. The plant capsule formulation of claim 1,
the capsule shell has a thickness of 0.1mm to 1mm, and the functional preparation has a weight of 0.2g to 1.2 g.
9. The plant capsule formulation of claim 1,
the plant capsule preparation comprises an additive added into the functional preparation, and the additive is one or more of an antioxidant, essence and a pigment.
10. The plant capsule formulation of claim 1 or 6,
the functional agent comprises one or more of palmitic acid or a derivative thereof, palmitoleic acid or a derivative thereof, oleic acid or a derivative thereof, linoleic acid or a derivative thereof, linolenic acid or a derivative thereof, stearidonic acid or a derivative thereof, eicosatrienoic acid or a derivative thereof, eicosatetraenoic acid or a derivative thereof, eicosapentaenoic acid or a derivative thereof.
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