CN108308597A - A kind of malnutrition tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of malnutrition tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN108308597A
CN108308597A CN201711269094.2A CN201711269094A CN108308597A CN 108308597 A CN108308597 A CN 108308597A CN 201711269094 A CN201711269094 A CN 201711269094A CN 108308597 A CN108308597 A CN 108308597A
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parts
powder
vitamin
nutrient formulation
fat
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不公告发明人
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of malnutritive tailored version clinical nutrition formulas and preparation method thereof, and the nutrient formulation includes the component of following parts by weight：16 22 parts of protein, 8 15 parts of fat, 40 55 parts of carbohydrate, 4.8 7 parts of water-soluble dietary fibers, 12 parts of insoluble diedairy fibers, 0.6 1.2 parts of macroelements, 0.01 0.04 parts of trace elements, 0.005 0.02 parts of liposoluble vitamins, 0.008 0.2 parts of water soluble vitamins, 01 parts of diet essence, 0.1 2 parts of integration of drinking and medicinal herbs ingredients, 0.1 3 parts of natural plants compounds and 0.005 2 parts of new resource foods；Nutrient formulation ingredient of the present invention safety, it is without any side effects, especially suitable for preventing to improve 10 years old or more the malnutritive symptom of crowd, significant effect, and can take for a long time.

Description

A kind of malnutrition tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to a kind of nutrient formulation and preparation method thereof, more particularly to one kind is exclusively used in preventing to improve malnutritive Nutrient formulation of problem and preparation method thereof.
Background technology
Malnutrition is the term of a description health status, caused by inappropriate or insufficient diet.It is commonly referred to as Due to the subalimentation caused by insufficiency of intake, malabsorption or excessive loss's nutrient, it is also possible to comprising due to crapulence Gluttony or the specific nutrient of excessive intake and caused by overnutrition.If being unable to taken long-term by right quantity, type Or the healthy diet that the nutrient of quality is constituted, individual will be malnutritive.Long-term malnutrition may lead to hungry death. If adult is malnutritive, following symptom is had：
One, osteoporosis
The substantial of sclerotin was accumulated since childhood, and the deposition velocity of calcium is most fast before 20 years old, reaches peak by 35 years old.Such as Ideal high level is not achieved with osteoid in 35 years old in fruit, then increasing with the age, the danger that osteoporosis occurs just will increase. The clinical manifestation of osteoporosis：(1) waist and leg ache：Often there is Leg Cramps, malaise, pain in the middle-aged and the old, and when pain is light Shi Chong, pain obviously aggravates after fatigue；(2) height reduces：The elderly is also easy to produce " hunchback " after suffering from osteoporosis, body cannot Uprightly, height relative reduction；(3) easily hair is fractured：Bone can be all caused when sufferers of osteoporosis face such as falls down, sprains, even getting up accidentally Folding, severe patient may occur from hair property fracture, and fracture mostly occurs in the positions such as more backbone and ilium joint of easily being collided and born a heavy burden, Very big inconvenience is brought to life of elderly person.
The intake of the current calcium in China universal relatively low (standard of supply amount is also not achieved 50%) is to cause osteoporosis The main reason for, other are as there is interfere calcium uptake and many factors that utilize, if phosphorus, ca proportion are improper, diet in diet It is middle that there are the intakes that more phytic acid, oxalic acid etc. interfere calcium, so supplement calcium agent appropriate can effectively supply internal calcium deficiency, Increase children and youth bone density, slows down the loss of calcium in person in middle and old age's bone, reduce the incidence of osteoporosis.
Two, hypoferric anemia
Iron is the important substance of hemoglobin in human body hematopoiesis, manufacture red blood cell, also participates in the function of many important enzymes.Body When interior asiderosis, can damage nerve, digestion, muscle and immune system function, show as it is mucocutaneous pale or greenish yellow, with Mouth, lip, eye conjunctiva and lactulum unguis crime are apparent, and general fatigue is powerless, attention cannot be concentrated, school grade declines, working efficiency Reduction, abnormal behavior etc..There are many reason for causing hypoferric anemia occurred frequently, and unreasonable dietary structure and poor eating habits are Main cause.Since the intake of vegetalitas iron in China's diet accounts for 70-90%.And human body to the absorptivity of vegetalitas iron very It is low, so, it should be noted that the supplement of dietary iron, i.e., reasonably combined dietary vitamins C can promote the absorption of iron therefore to answer daily It eats more and is rich in ascorbic fruit and fresh vegetables a bit, can also prevent internal iron deficiency.In addition, infant, in second growth send out Teenager and the pregnant woman for educating peak period are big to the demand of iron, are susceptible to suffer from hypoferric anemia, more it should be noted that the supplement of iron.
Three, fat
In recent years, fat incidence is in rising trend in full crowd, is more, fat main cause with city dweller especially It is to take in high thermal energy, high-fat food for a long time, i.e., so-called delicious food causes in excess fat memory bank, causes fertilizer It is fat.Obesity not only makes human posture too fat to move, and locomitivity declines, it is often more important that influences the health status of human body, overweight people's painstaking effort Pipe disease, diabetes incidence be significantly larger than the incidence of Normal-weight person.
Four, hypertension
There are about 50,000,000 hypertensive patients including critical hypertension in the whole nation at present.Studies have shown that the generation of hypertension It is positively correlated with the intake of salt, i.e., salinity is bigger, and the incidence of hypertension is higher.The intake of China's resident's salt compared with Height reaches 13-15 grams daily, and the World Health Organization suggests that the intake of daily salt should be less than 6 grams.Therefore, limitation salt should be limited Intake.It is another have the result shows that, calcium can be acted on the liter blood pressure of antagonism sodium, and therefore, the intake for increasing calcium has secondary buck work With.
Five, angiocardiopathy
In angiocardiopathy, coronary heart disease occupies critical role.The main reason for serum elevated cholesterol is its morbidity it One.Saturated fatty acid can be such that serum cholesterol level increases, therefore eat less containing the high food of saturated fatty acid, such as tallow Fat.And the polyunsaturated fatty acid in diet makes serum cholesterol decline, a variety of beans, especially soya bean, soya-bean oil containing it is more not Saturated fatty acid, therefore advocate more food beans and its product.In addition, increasing the intake of dietary fiber, the excretion of cholesterol can be promoted, Rich fibrous food has coarse food grain, vegetables and fruit etc..Integrative therapy adult is malnutritive at present, and nutrition-allocated proportion is more single One, nutritional support cannot be comprehensively provided.The nutrition product for being directed to children the elderly in the market is more, and lacks to adult nutrient not A whole nutritional prod that can be directed to malnourished adult is badly in need of in good concern.
Invention content
It is an object of the present invention to solve above-mentioned the deficiencies in the prior art, provide a kind of malnutritive for preventing to improve The nutrient formulation of symptom, formula components safety is without any side effects, especially suitable for preventing to improve 10 years old or more crowd Malnutritive symptom, significant effect, and can taking for a long time.
To achieve the above object, the present invention uses following technical scheme：
A kind of malnutrition tailored version clinical nutrition formula, includes the component of following parts by weight：16-22 parts of protein, 8-15 parts of fat, 40-55 parts of carbohydrate, 4.8-7 parts of water-soluble dietary fibers, 1-2 parts of insoluble diedairy fibers, 0.6- 1.2 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water solubilitys The new money of vitamin, 0-1 parts of diet essence, 0.1-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts Source food.
Preferably, the protein is amino acid, protein peptides, PURE WHEY, soybean protein isolate, hydrolysis collagen egg In vain, whole milk powder, dried whole-egg, lactoferrin, colostrum, L-lysine-Pidolidone, Pidolidone, L-arginine, L- color ammonia At least one of acid, L-Glutamine, taurine, Valine, l-Isoleucine and L-Leu；The protein peptides are big In beans oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide and ovalbumin peptide extremely Few one kind；It is described fat be saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structured lipids, DHA, EPA, At least one of ARA and phosphatide；The carbohydrate is fructose, rock sugar, lactose, maltodextrin, tapioca and resistance At least one of starch；The dietary fiber be inulin, konjaku flour, galactooligosaccharide, oligofructose, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin and soybean fiber；The macroelement is calcium citrate, Pfansteihl At least one of calcium, calcium monohydrogen phosphate, K-IAO, sodium citrate and magnesium gluconate；The trace element is glucose In sour ferrous iron, potassium iodide, zinc gluconate, sodium selenite, copper gluconate, chromium sulfate, manganese gluconate and sodium molybdate extremely Few one kind；The liposoluble vitamin be vitamin A, beta carotene, vitamine D3, vitamin E and vitamin K1 at least It is a kind of；The water soluble vitamin is vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenic acid, leaf At least one of acid, niacin, choline, inositol and biotin；Diet essence be cereal, beans, potato, greengrocery, Homonemeae, At least one of nut-seed class, fish and shrimp, poultry meat and fruits, the cereal are rice meal, millet powder, black rice At least one of powder, coixlacrymajobi powder, corn flour, wheat germ powder, oatmeal and buckwheat, the beans are peameal, mung bean At least one of powder, black bean powder, red bean powder and soy meal, the potato are common yam rhizome powder, and the Vegetable powder is carrot meal, in vain At least one of carrot powder, pumpkin powder, spinach powder, tomato meal, broccoli powder and balsam pear powder；The Homonemeae is mushroom powder, sea Band at least one of powder and white fungus powder；The nut-seed class is pumpkin seed powder and/or lotus nut starch；The fish and shrimp are three texts Fish meal and/or cod meal；The poultry meat is at least one of chicken meal, powdered beef, pork liver powder and pig kidney powder；The water Fruit is at least one of red date powder, longan powder, apple powder, cherry powder, citrus powder and pyrus nivalis powder.
Preferably, the integration of drinking and medicinal herbs ingredient is the membrane of a chicken's gizzard, Chinese yam, sealwort, Poria cocos, raspberry, matrimony vine, Radix Glycyrrhizae, peppermint At least one of with lily；It is preferred that sealwort, Poria cocos, raspberry, matrimony vine, Radix Glycyrrhizae, peppermint and lily.
Preferably, the natural plants compound is l-cn, Glucosamine, oligofructose, lutein, plant steroid At least one of alcohol, lycopene, resveratrol and allicin；It is preferred that l-cn.
Preferably, the new resource food is first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, the leaf of bamboo Flavones, casein phosphopeptide, avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii Tratt, yeast beta-dextran, newborn mineral salt, pueraria root powder, At least one of Rosa roxburghii Tratt and xylo-oligosaccharide；It is preferred that avenabeta glucosan.
The invention also discloses a kind of methods preparing the malnutritive tailored version clinical nutrition formula, including following step Suddenly：
1) by the protein of predetermined weight, fat, nucleotide, carbohydrate, dietary fiber, macroelement, micro member Element, vitamin, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food are prepared into grain size respectively 150-250 μm of powder；
2) mixing machine that the powder obtained by step 1) is sequentially added to cone-type mixer or other forms is uniformly mixed system Formula mixture is obtained, it is spare after sterilization processing；
3) according to conventional technical means by the formula mixture in step 2) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
Preferably, the fat in the step 1) is powder fat.Further, the powder fat is according to following methods It prepares：Wall material, emulsifier, fat, stabilizer and water are mixed evenly, homogenization is then carried out, finally sprays Dry obtained powder fat.It is preferred that the wall material is that maltodextrin, soybean protein isolate, whole-fat milk powder, dietary fiber are preferably anti- At least one of property dextrin, inulin, PURE WHEY, oligoisomaltose, soybean fiber, Arabic gum and candy sugar powder.It is excellent It is at least one of monoglyceride and Tween 80 to select the emulsifier.It is preferred that the stabilizer is agar.The fat is olive At least one of oil, soybean oil, coconut oil, perilla herb oil, medium chain triglyceride, single diglycerine fatty acid ester.
Preferably, the integration of drinking and medicinal herbs ingredient in the step 1) is prepared by following methods：Using pulverizer to predetermined weight The raw material of number crushes, and the raw material of crushing is placed in container, and 3~8 times of the water that weight is raw material weight is added, carries out Impregnate 3~4 hours, 30~60min of decoction then carried out to soak, filtering removal raw material leaves and takes decoction liquor, to decoction liquor into Row spray drying, integration of drinking and medicinal herbs component powders are prepared with 60~80 mesh screenings.
Preferably, the vitamin in the step 1) is prepared by following methods：The fat-soluble dimension of predetermined weight number is given birth to Element is used as core material, and carragheen, Arabic gum is selected to be used as wall material, carries out 2 emulsifying homogeneous under high pressure and handles, when emulsifying homogeneous Between be 10~15min, then carry out instantaneous drying of spraying, liposoluble vitamin powder prepared with 60~80 mesh screenings；It will make a reservation for The water soluble vitamin of parts by weight is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, spraying is instantaneous as core material It is dry, prepare water soluble vitamin powder with 60~80 mesh screenings.
Preferably, suitable food thickening agent and food additives can be increased in step 3).The food thickening agent is At least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum, the food Product additive is at least one of Aspartame, food flavor fragrance, brown sugar；It is preferred that carragheen, Arabic gum, guar gum, At least one of Aspartame and food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
The invention also discloses a kind of methods that wet processing prepares malnutritive tailored version clinical nutrition formula, including such as Lower step：
Step 1) prepares the protein containing predetermined weight number and amino acid, nucleotide, fat, carbohydrate, meals Eat the original of fiber, macroelement, trace element, vitamin, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food Material is added according to the physical behavior of raw material according to sequencing successively, is stirred while addition, raw material is made Mixed emulsion；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), and sieving is prepared into powder, and by above-mentioned powder system For at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
The advantage of the invention is that：
1, nutrient formulation of the present invention was specifically for 10 years old or more crowd, and malnutritive patient grinds within especially 10 years old or more Prepared by hair, be suitable for preventing and improving the malnutritive symptom of patient, and nutrient formulation of the present invention is taken simply, without any Toxic side effect can be taken for a long time.
2, nutrient formulation of the present invention is remarkably improved the immunity of patient, combines for treating patient's with drug (such as cancer, diabetes, hypertension, hyperlipidemia) has excellent synergistic therapeutic effect when a variety of diseases, can significantly reduce medicine The dosage of product mitigates the toxic side effect of drug, improves the physiological function of patient, extends the service life of patient, improves the life of patient Quality.
3, nutrient formulation of the present invention is remarkably improved the learning cognition ability of patient, mitigates or repair brain tissue damage Wound.
Specific implementation mode
Embodiment 1：
PURE WHEY 9.1g, soybean protein isolate 7.3g, whole milk powder 21.8g, dried whole-egg 0.18g, colostrum 0.1g, Taurine 0.12g, ocean fish oligopeptide powder 0.1g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride 0.21g；Maltodextrin 28.4g, rock sugar 5.3g, lactose 0.9g；Aqueous soluble dietary in dietary fiber Fiber 6g, insoluble diedairy fiber 1.8g；Calcium 0.27g, phosphorus 0.27g, potassium 0.08g, sodium 0.31g, magnesium 0.14g in macroelement； Iron 0.009g, iodine 0.00014g, zinc 0.005g in trace element；Vitamin A 0.0006g, beta carotene in liposoluble vitamin 0.000057g, vitamine D3 0.000001g, vitamin E 0.009g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.001g, vitamin B120.0000005g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000065g, niacin 0.0161g；Jujube 0.1g；Lily 0.1g in integration of drinking and medicinal herbs ingredient, peppermint 0.1g, Poria cocos 0.1g, basin is covered Sub- 0.1g, Radix Glycyrrhizae 0.1g, matrimony vine 0.1g, sealwort 0.1g；L-cn 0.64g in natural plants compound；In new resource food Avenabeta glucosan 0.2g.
Embodiment 2
PURE WHEY 9.1g, soybean protein isolate 7.3g, whole milk powder 21.8g, dried whole-egg 0.18g, colostrum 0.1g, Taurine 0.12g, ocean fish oligopeptide powder 0.1g；Olive oil 3.78g, soybean oil 6.1g, coconut oil 3.78g, perilla herb oil 0.64g, medium chain triglyceride 0.29g；Maltodextrin 23.4g, rock sugar 5.3g, lactose 0.9g；Aqueous soluble dietary in dietary fiber Fiber 6g, insoluble diedairy fiber 1.8g；Calcium 0.27g, phosphorus 0.27g, potassium 0.08g, sodium 0.31g, magnesium 0.14g in macroelement； Iron 0.009g, iodine 0.00014g, zinc 0.005g in trace element；Vitamin A 0.0006g, beta carotene in liposoluble vitamin 0.000057g, vitamine D3 0.000001g, vitamin E 0.009g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.001g, vitamin B120.0000005g, vitamin C 0.117g, pantothenic acid 0.003g, folic acid 0.000065g, niacin 0.0161g；Jujube 0.1g；Lily 0.1g in integration of drinking and medicinal herbs ingredient, peppermint 0.1g, Poria cocos 0.1g, basin is covered Sub- 0.1g, Radix Glycyrrhizae 0.1g, matrimony vine 0.1g, sealwort 0.1g；L-cn 0.64g in natural plants compound；In new resource food Avenabeta glucosan 0.2g.
Embodiment 3
PURE WHEY 9.1g, soybean protein isolate 7.3g, whole milk powder 21.8g, dried whole-egg 0.18g, colostrum 0.1g, Taurine 0.12g, ocean fish oligopeptide powder 0.1g；Olive oil 3.78g, soybean oil 6.1g, coconut oil 3.78g, perilla herb oil 0.64g, medium chain triglyceride 0.29g；Maltodextrin 23.4g, rock sugar 5.3g, lactose 0.9g；Aqueous soluble dietary in dietary fiber Fiber 6g, insoluble diedairy fiber 1.8g；Calcium 0.27g, phosphorus 0.27g, potassium 0.08g, sodium 0.31g, magnesium 0.14g in macroelement； Iron 0.009g, iodine 0.00014g, zinc 0.005g in trace element；Vitamin A 0.0006g, beta carotene in liposoluble vitamin 0.000057g, vitamine D3 0.000001g, vitamin E 0.009g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.001g, vitamin B120.0000005g, vitamin C 0.117g, pantothenic acid 0.003g, leaf Sour 0.000065g, niacin 0.0161g；Jujube 0.1g；Lily 0.01g in integration of drinking and medicinal herbs ingredient, peppermint 0.01g, Poria cocos 0.01g, Raspberry 0.01g, Radix Glycyrrhizae 0.01g, matrimony vine 0.01g, sealwort 0.01g；L-cn 0.64g in natural plants compound；New money Avenabeta glucosan 0.2g in the food of source.
Embodiment 4：
PURE WHEY 9.1g, soybean protein isolate 7.3g, whole milk powder 21.8g, dried whole-egg 0.18g, colostrum 0.1g, Taurine 0.12g, ocean fish oligopeptide powder 0.1g；Olive oil 2.77g, soybean oil 4.48g, coconut oil 2.77g, perilla herb oil 0.64g, medium chain triglyceride 0.21g；Maltodextrin 23.4g, rock sugar 5.3g, lactose 0.9g；Aqueous soluble dietary in dietary fiber Fiber 6g, insoluble diedairy fiber 1.8g；Calcium 0.27g, phosphorus 0.27g, potassium 0.08g, sodium 0.31g, magnesium 0.14g in macroelement； Iron 0.009g, iodine 0.00014g, zinc 0.005g in trace element；Vitamin A 0.0006g, beta carotene in liposoluble vitamin 0.000057g, vitamine D3 0.000001g, vitamin E 0.009g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.001g, vitamin B120.0000005g, vitamin C 0.117g, pantothenic acid 0.003g, leaf Sour 0.000065g, niacin 0.0161g；Jujube 0.1g；Lily 0.01g in integration of drinking and medicinal herbs ingredient, peppermint 0.01g, Poria cocos 0.01g, Raspberry 0.01g, Radix Glycyrrhizae 0.01g, matrimony vine 0.01g, sealwort 0.01g；L-cn 0.64g in natural plants compound；New money Avenabeta glucosan 0.01g in the food of source.
Embodiment 5：
The method for preparing nutrient formulation described in embodiment 1-4, is as follows：
1) by the protein of predetermined weight, fat, nucleotide, carbohydrate, dietary fiber, macroelement, micro member Element, vitamin, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food are prepared into grain size respectively 150-250 μm of powder；
2) mixing machine that the powder obtained by step 1) is sequentially added to cone-type mixer or other forms is uniformly mixed system Formula mixture is obtained, it is spare after sterilization processing；
3) according to conventional technical means by the formula mixture in step 2) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
Fat in the step 1) is powder fat, and is prepared according to following methods：By wall material, emulsifier, fat, steady Determine agent to be mixed evenly with water, then carry out homogenization, finally carries out being spray-dried obtained powder fat.
Integration of drinking and medicinal herbs ingredient in the step 1) is prepared by following methods：Using pulverizer to the original of predetermined weight number Material crushes, and the raw material of crushing is placed in container, and 3~8 times of the water that weight is raw material weight is added, carries out immersion 3~4 Hour, 30~60min of decoction then is carried out to soak, filtering removal raw material leaves and takes decoction liquor, and it is dry to carry out spraying to decoction liquor It is dry, prepare integration of drinking and medicinal herbs component powders with 60~80 mesh screenings.
Vitamin in the step 1) is prepared by following methods：Using the liposoluble vitamin of predetermined weight number as core Material, selects carragheen, Arabic gum to be used as wall material, carries out the processing of 2 emulsifying homogeneous under high pressure, the emulsifying homogeneous time for 10~ Then 15min carries out instantaneous drying of spraying, liposoluble vitamin powder is prepared with 60~80 mesh screenings；By predetermined weight number Water soluble vitamin as core material, select maltodextrin, lipoprotein to be used as wall material, be uniformly mixed, the instantaneous drying of spraying, with 60 ~80 mesh screenings prepare water soluble vitamin powder.
Suitable food thickening agent and food additives can be increased in step 3).The food thickening agent be guar gum, At least one of xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum, the food addition Agent is at least one of Aspartame, food flavor fragrance, brown sugar；It is preferred that carragheen, Arabic gum, guar gum, A Siba At least one of sweet tea and food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 6：Effect experiment
1, synergistic therapeutic effect of the nutrient formulation described in embodiment 1-4 to diabetic mice：
Establish diabetes model：August age, weight 25-27g SPF grades experiment mice totally 80, every 10 are divided into one group, Totally 8 groups, wherein 1 group is blank control group, with conventional method by 7 groups of mouse inductive formation diabetes other than blank control group, And blood glucose is higher than 20mmol/L.4 groups of mouse (feeding dosage 0.5g/ is fed respectively with the nutrient powder prepared in embodiment 1-4 10g), and subcutaneous insulin injections 0.02ml/10g (insulin preparation 0.5U/ml)；One comparative example, 1 group of hypodermic injection pancreas islet Plain 0.025ml/10g (insulin preparation 0.5U/ml)；2 groups of subcutaneous insulin injections 0.05ml/10g (pancreas islet of another comparative example Plain preparation 0.5U/ml)；3 groups of another comparative example feeds the nutrient powder prepared in embodiment 1；Blank control group feeding same amount is steamed Distilled water；Every morning 9-10 point is fed and is injected, free water and feed during raising.The 20th day after injection treatment, prohibit Food 12 hours extracts eyeball and takes blood, detects blood glucose value, the results are shown in Table 1：
Table 1
The effect of nutrient formulation of the present invention known to embodiment 1-4 in table 1 and comparative example 1 can significantly improve insulin, from And the dosage of insulin is reduced, it is hypoglycemic when insulin is combined with nutrient formulation of the present invention for treating diabetes mice Effect outclass be used alone insulin effect；And the dosage of insulin is only usual dosage (as shown in comparative example 2) Half.This not only considerably reduces the medical expense of patient, while decreasing toxic side effect of the drug to patient.By comparing Known to example 3 when nutrient formulation of the present invention is used alone, mouse blood sugar value has not only obtained good control, and there are one bright Aobvious decline.
2, the nutrient formulation prepared by embodiment 1-4 is used to improve the survival rate of lung cancer in mice：
Establish lung cancer model：In August age, the mouse of weight 25-27g totally 60, every 10 are divided into one group, totally 6 groups.Wherein 1 Group is blank control group, with conventional method by 5 groups of mouse inductive formation Lewis lung cancer other than blank control group, diameter of tumor 8-10mm.Wherein 4 groups of mouse (feeding dosage 0.5g/10g), and abdominal cavity are fed respectively with the nutrient powder prepared in embodiment 1-4 Inject gemcitabine (50mg/kg)；One comparative example group intraperitoneal injection gemcitabine (50mg/kg)；Blank control group injection etc. Measure physiological saline；Nutrient powder is fed daily, is injected twice a week, free water feeding during raising.Every two weeks to the life of mouse It manages activity change and is recorded life cycle, the results are shown in Table 2.
Table 2
As shown in Table 2, nutrient formulation of the present invention can significantly extend the life cycle of lung cancer in mice, mitigate chemotherapy pain Hardship is improved the quality of living.
3, the nutrient formulation prepared by embodiment 1-4 is used to improve the physiological function of rat：August age SPF rats 50, body Weight 320-350g；It is divided into 5 groups by blood pressure blood fat horizontal distribution, 1 group is control group, and 4 groups are embodiment 1-4 groups, every group 10 big Mouse；Prepared nutrient powder (0.3g/10g) in the daily feeding embodiment 1-4 of embodiment 1-4 groups；During raising each group rat from By drinking-water feeding.The physiological function index of each group rat is recorded every two weeks, and the results are shown in Table 3：
Table 3
As shown in Table 3, nutrient formulation of the present invention can obviously improve Hypertension Rats hyperlipidemic conditions, and effectively reduce rat Internal MDA contents, have significant antioxidant and anti-aging effect.
4, nutrient formulation described in embodiment 1-4 is for improving cognitive ability of rat：
60 August age rats are subjected to Y maze spatials guided learning and training, latter every 10 up to standard are divided into one group, respectively For sham-operation (Sham) group, VaD groups, 1 nutrient powder nursing group of VaD+ embodiments, 2 nutrient powder nursing group of VaD+ embodiments, VaD+ realities Apply 3 nutrient powder nursing group of example, 4 nutrient powder nursing group of VaD+ embodiments.VaD models are established with conventional method, after 12 weeks, detection is each The learning cognition ability of group rat, parallel organization are sliced HE dyeing observation hippocampal tissue pathological changes.As a result it shows：With Sham groups It compares, the learning cognition ability of remaining 5 groups of rat is decreased obviously, and VaD groups decline especially pronounced；Histotomy shows, with Sham groups are compared, remaining 5 groups of Rat hippocampus has different degrees of damage, but the damage of VaD groups is the most serious.It can be seen that this The learning cognition ability of senile dementia rat can be improved by inventing the nutrient formulation, mitigate and repair the damage of brain tissue.

Claims (6)

1. a kind of malnutrition tailored version clinical nutrition formula, it is characterised in that include the component of following parts by weight：16-22 parts Protein, 8-15 parts of fat, 40-55 parts of carbohydrate, 4.8-7 parts of water-soluble dietary fibers, 1-2 portions of insoluble diets are fine Dimension, 0.6-1.2 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts Water soluble vitamin, 0-1 parts of diet essence, 0.1-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 Part new resource food.
2. nutrient formulation as described in claim 1, wherein the diet essence is cereal, beans, potato, greengrocery, bacterium algae At least one of class, nut-seed class, fish and shrimp, poultry meat and fruits.
3. nutrient formulation as claimed in claim 1 or 2, wherein the integration of drinking and medicinal herbs ingredient is the membrane of a chicken's gizzard, Chinese yam, sealwort, Fu At least one of Siberian cocklebur, raspberry, matrimony vine, Radix Glycyrrhizae, peppermint and lily.
4. nutrient formulation as claimed in claim 1 or 2, wherein the natural plants compound is l-cn, aminoglucose At least one of sugar, oligofructose, lutein, phytosterol, lycopene, resveratrol and allicin.
5. nutrient formulation as claimed in claim 1 or 2, wherein the new resource food is first milk basic protein, gamma-amino fourth Acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, casein phosphopeptide, avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii Tratt, yeast β- At least one of glucan, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt and xylo-oligosaccharide.
6. a kind of method preparing nutrient formulation described in claim 1, includes the following steps：
1) by the protein of predetermined weight, fat, nucleotide, carbohydrate, dietary fiber, macroelement, trace element, dimension It is 150-250 μ that raw element, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food are prepared into grain size respectively The powder of m；
2) mixing machine that the powder obtained by step 1) is sequentially added to cone-type mixer or other forms is uniformly mixed obtained match Square mixture, it is spare after sterilization processing；
3) formula mixture in step 2) is prepared by nutrient powder, nutrition emulsion, capsule, piece according to conventional technical means At least one of agent, pill or oral solution.
CN201711269094.2A 2017-12-05 2017-12-05 A kind of malnutrition tailored version clinical nutrition formula and preparation method thereof Pending CN108308597A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109497563A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 Leucoderma tailored version clinical nutrition formula and preparation method thereof
CN110393293A (en) * 2019-07-05 2019-11-01 上海复旦奥医医学科技有限公司 A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof
CN111248402A (en) * 2020-01-16 2020-06-09 深圳市华大农业应用研究院 Dietary food for treating malnutrition and preparation method thereof
CN113785971A (en) * 2021-09-16 2021-12-14 首都医科大学附属北京友谊医院 Health meal composition and processing method and application thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109497563A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 Leucoderma tailored version clinical nutrition formula and preparation method thereof
CN110393293A (en) * 2019-07-05 2019-11-01 上海复旦奥医医学科技有限公司 A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof
CN111248402A (en) * 2020-01-16 2020-06-09 深圳市华大农业应用研究院 Dietary food for treating malnutrition and preparation method thereof
CN113785971A (en) * 2021-09-16 2021-12-14 首都医科大学附属北京友谊医院 Health meal composition and processing method and application thereof
CN113785971B (en) * 2021-09-16 2023-09-22 首都医科大学附属北京友谊医院 Health meal composition and processing method and application thereof

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Application publication date: 20180724