JP2019135217A - Powder composition, method for producing powder composition, dry eye improving agent, skin quality improving agent, food and drink, cosmetic, and pet food - Google Patents

Abstract

To provide powder compositions with a small amount of functional oils and fats required for exerting an effect and with high storage stability, to provide methods for producing the powder compositions, and to provide dry eye improving agents, skin quality improving agents, foods and drinks, cosmetics, and pet foods.SOLUTION: A powder composition contains a functional fat and oil, a modified starch, and a powder medium. The mass ratio of the mass of the functional fat and oil to the mass of the powder medium is 10/90 to 70/30. A method for producing the powder composition, which forms a wet mixture comprising a functional oil, a modified starch, a powder medium and an aqueous medium, is disclosed. The aqueous medium is removed from the wet mixture. The mass ratio of the mass of the functional fat and oil to the mass of the powder medium is 10/90 to 70/30.SELECTED DRAWING: None

Description

  The present disclosure relates to a powdery composition, a method for producing the powdery composition, a dry eye improving agent, a skin quality improving agent, food and drink, cosmetics, and pet food.

  Sea buckhorn (scientific name Hippophae rhhamnoides) is a deciduous shrub plant of the family Gummyaceae. Sea buckthorn grows naturally in a wide range of regions such as China, Inner Mongolia, Russia and Eastern Europe.

  For fats and oils contained in sea buckthorn (hereinafter referred to as sea buckthorn oil), many physiological activities such as dry eye improvement effect (Non-patent Documents 1 and 2), atopic dermatitis improvement effect (Non-patent Document 3) Has been reported. Sea buckthorn oil has long been used in medicines, health foods, cosmetics, and the like.

Effects of Oral Sea Buckthorn Oil on Tear Film Fatty Acids in Individuals With Dry Eye (Cornea _ Volume 30, Number 9, September 2011) Oral Sea Buckthorn Oil Attenuates Tear Film Osmolarity and Symptoms in Individuals with Dry Eye1-4 (The Journal of Nutrition Nutrition and Disease) Effects of Dietary Supplementation of Seabuckthorn (Hippophae rhamnoides) Oils on Fatty Acids in Patients with Atopic Dermatitis

  Excessive intake of functional oils such as sea buckthorn oil may cause diarrhea in some people. Moreover, functional fats and oils such as sea buckthorn oil are generally expensive. Therefore, it is preferable that the amount of functional fats and oils necessary for achieving the effect is small. Functional oils and fats generally have low storage stability.

  One aspect of the present disclosure is a powdery composition having a small amount of functional oil and fat necessary for producing an effect and having high storage stability, a method for producing a powdery composition, a dry eye improving agent, a skin quality improving agent, The object is to provide food and drink, cosmetics, and pet food.

One aspect of the present disclosure includes functional oil and fat, modified starch, and a powdered medium, and a mass ratio of the mass of the functional oil and fat to the mass of the powdered medium is 10/90 to 70/30. It is a powdery composition.
The powdery composition which is one aspect of the present disclosure has high storage stability. Moreover, in the powdery composition which is 1 aspect of this indication, the quantity of functional fats and oils required in order to show an effect may be small.

  Another aspect of the present disclosure is a method for producing a powdery composition, wherein a wet mixture including a functional oil, a modified starch, a powdered medium, and an aqueous medium is formed, and the aqueous mixture is formed from the wet mixture. It is a manufacturing method of the powdery composition which removes a medium and the mass ratio of the mass of the said functional fat / oil with respect to the mass of the said powdery medium is 10 / 90-70 / 30.

  According to the method for producing a powdery composition which is another aspect of the present disclosure, a powdery composition having high storage stability can be produced. Moreover, in the powdery composition manufactured with the manufacturing method of the powdery composition which is another situation of this indication, the quantity of functional fats and oils required in order to show an effect may be small.

Exemplary embodiments of the present disclosure are described.
1. Powdery composition The powdery composition of this indication contains functional fats and oils. Functional fats and oils are fats and oils containing a lipophilic component having a physiologically active function or a component having a physiologically active function. Functional fats and oils are derived from animals and plants, for example. Functional fats and oils correspond to foodstuffs or food additives, for example. Examples of functional oils include glycerin fatty acid esters, carotenoids, and fat-soluble vitamins.

  Examples of the fatty acid chain in the glycerin fatty acid ester include one or more selected from the group consisting of palmitoleic acid, palmitic acid, oleic acid, α-linolenic acid, stearic acid, eicosapentaenoic acid, and docosahexaenoic acid.

  Examples of carotenoids include one or more selected from the group consisting of β-carotene, lutein, β-cryptoxanthin, lycopene, and vitamin A. Examples of the fat-soluble vitamins include one or more selected from the group consisting of tocopherol (vitamin E) and vitamin A.

  Examples of functional fats and oils include sea buckthorn oil or components thereof. Sea buckthorn fruit includes fruit juice and sea buckthorn oil. Fruit juice contains vitamins, amino acids, minerals, flavonoids and the like. Flavonoids include isorhamnetin, kaempferol, quercetin and their dividends. Sea buckthorn oil contains fatty acids, carotenoids and the like. Fatty acids include palmitoleic acid, palmitic acid, oleic acid, α-linolenic acid, stearic acid, eicosapentaenoic acid, docosahexaenoic acid and the like. Carotenoids include tocopherol, α-carotene, β-carotene, lutein, β-cryptoxanthin, lycopene, vitamin A and the like.

  Sea buckthorn oil can be obtained by methods such as fruit juice extraction, centrifugation, extraction using an organic solvent, and extraction using supercritical carbon dioxide. Examples of the organic solvent used for extraction include alcohol, normal hexane, and ethyl acetate.

Examples of functional oils and fats include commercially available functional oils and fats. Examples of functional fats and oils include functional fats and oils extracted and purified from animals and plants and algae.
Modified starch means starch that has been subjected to physical, chemical or enzymatic treatment to improve its properties. The processed starch in the present disclosure preferably corresponds to a food or food additive. In the powdery composition of the present disclosure, the content of the modified starch is preferably 15 to 90 parts by mass with respect to 100 parts by mass of the functional oil. When the content of the modified starch is within this range, the oxidation and fading of the functional oil during storage can be further suppressed.

  A powdery medium means what becomes an excipient | filler which assists becoming powder when functional fats and oils are used for a pulverization process. Examples of the powder medium include one or more selected from the group consisting of starch, calcium hydrogen phosphate, magnesium trisilicate, crystalline cellulose, lactose hydrate, and mannitol. The powdery medium absorbs and retains at least a part of the functional oil and fat, for example.

  In the powder composition of the present disclosure, the mass ratio of the functional oil / fat to the mass of the powdery medium (hereinafter referred to as oil / fat / medium mass ratio) is 10/90 to 70/30. When the oil / fat / medium mass ratio is 10/90 to 70/30, the storage stability of the powdery composition is high. The oil / fat / medium mass ratio is preferably 15/85 to 65/35, and more preferably 20/80 to 60/40. When the oil / fat / medium mass ratio is 15/85 to 65/35, the storage stability of the powdery composition is even higher, and when the oil / fat / medium mass ratio is 20/80 to 60/40, The storage stability of is particularly high.

  Moreover, the required intake of a powdery composition can be suppressed because fat / medium mass ratio is 10/90 or more. When the oil / fat / medium mass ratio is 70/30 or less, leakage of functional oil / fat from the powdery medium can be suppressed.

The powdery composition of this indication may further contain other ingredients. Examples of other components include an antioxidant and an emulsifier. Examples of the antioxidant include vitamin E and vitamin C palmitate. When the powdery composition contains an antioxidant, the storage stability of the powdery composition is further improved. Examples of the emulsifier include glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, lecithin, saponin, and sodium caseinate.
The powdery composition of the present disclosure has high storage stability. The storage stability includes, for example, a characteristic that oxidation and fading hardly occur. Moreover, the powdery composition of this indication accelerates | stimulates absorption of the functional fats and oils by a biological body. Therefore, in the powdery composition of the present disclosure, the amount of functional fats and oils necessary for achieving the effect is small.

2. Manufacturing method of powdery composition In the manufacturing method of the powdery composition of this indication, the wet mixture containing functional fats and oils, modified starch, a powdery medium, and an aqueous medium is formed. Examples of the aqueous medium include water and hydrous ethanol. In the wet mixture, the fat / medium mass ratio is, for example, 10/90 to 70/30.

  The wet mixture can be formed, for example, as follows. First, a modified starch, a powdery medium, and an aqueous medium are mixed to prepare an admixture. An emulsifier may be further mixed in the mixed solution. For mixing the admixture, for example, a high-speed stirrer or a homogenizer can be used. The rotational speed of the high-speed stirrer or homogenizer is preferably 2000 rpm or more. The temperature at which the admixture is mixed is preferably 20 ° C or higher, and more preferably 30 ° C or higher.

  Next, functional fats and oils are dropped into the admixture and dispersed. When dropping functional oil and fat, it is preferable to stir using a high-speed stirrer or a homogenizer. When the functional oil or fat is dropped, the rotational speed of the high-speed stirrer or homogenizer is preferably 3000 rpm or more. When functional oil is added dropwise, the temperature of the mixed solution is preferably 30 to 50 ° C. Through the above steps, a wet mixture can be formed. In addition, a functional mixture, modified starch, powdered medium, and aqueous medium may be mixed to form a wet mixture.

  The wet mixture preferably has micelles. The median diameter in the wet mixture is preferably 50 μm or less. When the median diameter in the wet mixture is 50 μm or less, the compatibility between the functional oil and the aqueous medium increases, and separation becomes difficult. Moreover, it becomes difficult for functional fats and oils to leak from a powdery medium after pulverization. Furthermore, the absorbability of the functional fat / oil to the living body is improved, and the effect of the functional fat / oil can be achieved in a smaller amount than when the functional fat / oil is ingested alone.

  The measuring method of the median diameter in the wet mixture is as follows. Disperse the wet mixture in pure water to make a sample. Next, the median diameter of the sample is measured using a laser diffraction / scattering particle size distribution measuring device (LA-920, manufactured by Horiba, Ltd.). The measured value of the median diameter in this measurement is the median diameter in the wet mixture.

  Thereafter, the aqueous medium is removed from the wet mixture. The method for removing the aqueous medium can be appropriately selected from known methods. The method of removing the aqueous medium is preferably a method that does not destroy the micelles of the wet mixture. Examples of the method for removing the aqueous medium include a spray drying method, a fluidized bed granulation method, a heating vacuum drying method, and a freeze drying method.

In the produced powdery composition, the oil / fat / medium mass ratio is 10/90 to 70/30.
3. Products comprising the powdered composition Various products comprising the powdered composition of the present disclosure can be produced. Examples of products include supplements, foods, beverages, cosmetics, shampoos, rinses, pet foods, and the like. Examples of supplements include dry eye improving agents and skin quality improving agents. In the supplement, the powdery composition is blended in, for example, a tablet. In the supplement, the powdery composition is filled in capsules, for example. In the supplement, the powdery composition has, for example, the form of granules.

  Examples of the food include dairy products and baked confectionery. Examples of dairy products include yogurt. Examples of the baked confectionery include cookies. Examples of cosmetics include creams and emulsions.

4). Example (1) Production of powdery composition of Example 1 3 kg of sea buckthorn fruit was ground. Normal hexane (12 L) was added to the ground fruit, and the mixture was extracted by stirring at 50 ° C. for 1 hour. Then, after cooling to room temperature, suction filtration was carried out. The filtrate was transferred to a separatory funnel to obtain a normal hexane fraction. The normal hexane fraction was dried over sodium sulfate and further concentrated under reduced pressure at 35 ° C. to obtain 48 g of sea buckthorn oil. Sea buckthorn oil corresponds to functional fats and oils.

  26 g of sea buckthorn oil, 23 g of modified starch, 24 g of dextrin, and 425 g of water were mixed and stirred using a homogenizer to form a uniform wet mixture. Dextrin is trade name: Pinedex (registered trademark) # 2 manufactured by Matsutani Chemical Industry Co., Ltd. Dextrin corresponds to a powdered medium. Water corresponds to an aqueous medium.

Next, water was removed from the wet mixture by lyophilization to obtain 130 g of the powdery composition of Example 1.
(2) Manufacture of powdery compositions of Examples 2 to 10 and Comparative Examples 1 to 4 Basically in the same manner as Example 1, powders of Examples 2 to 10 and Comparative Examples 1 to 4 A composition was prepared. However, Table 1 shows the types of components to be mixed to form a wet mixture, and the components and blending amounts. The unit of the blending amount in Table 1 is gram (g).

表１におけるＳＯは、シーバックソーンオイルを意味する。表１におけるパインデクス＃３は、松谷化学工業株式会社製のデキストリンの商品名である。表１におけるＴＫ−１６は、三和澱粉工業株式会社製のデキストリンの商品名である。表１におけるα―ＣＤは、α―シクロデキストリンである。表１におけるβ―ＣＤは、β―シクロデキストリンである。表１におけるγ―ＣＤは、γ―シクロデキストリンである。表１におけるＴＢＤ−２０は、松谷化学社製のデキストリンの商品名である。パインデクス＃３、ＴＫ−１６、α―ＣＤ、β―ＣＤ、γ―ＣＤ、及びＴＢＤ−２０は粉状媒体に対応する。

SO in Table 1 means sea buckthorn oil. Pinedex # 3 in Table 1 is a trade name of dextrin manufactured by Matsutani Chemical Industry Co., Ltd. TK-16 in Table 1 is a trade name of dextrin manufactured by Sanwa Starch Kogyo Co., Ltd. Α-CD in Table 1 is α-cyclodextrin. Β-CD in Table 1 is β-cyclodextrin. Γ-CD in Table 1 is γ-cyclodextrin. TBD-20 in Table 1 is a trade name of dextrin manufactured by Matsutani Chemical. Pinedex # 3, TK-16, α-CD, β-CD, γ-CD, and TBD-20 correspond to powdered media.

No. in Table 1 681NU is a trade name of a food emulsifier manufactured by Taiyo Kagaku. No. 681NU corresponds to an emulsifier. Q-182S in Table 1 is a trade name of a food emulsifier manufactured by Taiyo Kagaku. Q-182S corresponds to an emulsifier. V. in Table 1 C. Palmitate is a trade name of an antioxidant manufactured by Mitsubishi Chemical Foods.
(3) Evaluation of storage stability Storage stability was evaluated about each of the powdery compositions of Examples 1-10 and Comparative Examples 1-4. The storage stability evaluation method is as follows.

A pigment component was extracted from the powdered composition immediately after production using ethanol. In the extract, the absorbance at a designated wavelength of 450 nm (hereinafter referred to as initial absorbance) was measured.
The powdery composition was sealed in a polyethylene bag, and stored for 20 days at a temperature of 50 ° C. and in a light-shielding environment. The powder composition after storage was measured for absorbance (hereinafter referred to as absorbance after storage) in the same manner as the method for measuring initial absorbance.

Next, the ratio of absorbance after storage to initial absorbance (hereinafter referred to as absorbance relative value) was calculated. The relative absorbance values are shown in Table 1 above.
Moreover, the external appearance of the powdery composition immediately after manufacture and the external appearance of the powdery composition after storage were observed visually. The change in appearance before and after storage was evaluated according to the following criteria. The evaluation results are shown in Table 1 above.

5: No change at all.
4: Slightly darker yellow.
3: About half of the yellow color became lighter.
2: A slight yellow color remains.
1: Completely whitened.
In the powdery compositions of Examples 1 to 10, the absorbance relative value was large and the change in appearance was small compared to the powdery compositions of Comparative Examples 1 to 4.

(4) Dry Eye Evaluation Dry eye evaluation was performed for each of the powdery compositions of Example 1 and Comparative Example 1 and the composition of Comparative Example 5. The form of the powder composition of Example 1 and Comparative Example 1 was a tablet. The composition of Comparative Example 5 is a soft capsule containing sea buckthorn oil. The dry eye evaluation method is as follows.

  Tear volume was measured by the Schirmer test I method in 6 subjects in their 20s and 50s who felt thirsty. A specific method for measuring the tear volume is as follows. A Schirmer test paper is placed between the eyes of the subject and maintained for 5 minutes. Next, the Schirmer test paper is removed from the corners of the eyes and the length wetted with tears is measured. Let the length wet with tears be the amount of tears before ingestion.

Next, the subject ingested any one of the following compositions (a) to (f) once a day for 30 days.
(A) Powdered composition of Example 1 immediately after production (b) Powdered composition of Example 1 stored at 50 ° C. for 20 days after production.

(C) The powdery composition of Comparative Example 1 immediately after production (d) The powdery composition of Comparative Example 1 stored at 50 ° C. for 20 days after production.
(E) Composition of Comparative Example 5 immediately after production (f) Powdered composition of Comparative Example 5 stored at 50 ° C. for 20 days after production.

  The daily intake of the compositions (a) to (d) is such that the amount of sea buckthorn oil is 100 mg. The daily intake of the compositions (e) to (f) is such that the amount of sea buckthorn oil is 300 mg.

  After completing the intake of the composition, the amount of tears of the subject was measured again. Let the amount of tears measured here be the amount of tears after ingestion. Table 2 shows the amount of tears before ingestion and the amount of tears after ingestion.

実施例１の粉状組成物を用いれば、涙液量を増加させることができた。また、実施例１の粉状組成物は、５０℃の下で２０日間保管した場合でも、涙液量を増加させることができた。

If the powdery composition of Example 1 was used, the amount of tears could be increased. Moreover, the powdery composition of Example 1 was able to increase the amount of tears even when stored at 50 ° C. for 20 days.

  The daily intake of sea buckthorn oil contained in the powdery composition of Example 1 is 1/3 of the daily intake of sea buckthorn oil contained in the composition of Comparative Example 5. However, the increase in tear volume when the powdery composition of Example 1 was ingested was equal to or greater than the increase in tear volume when the composition of Comparative Example 3 was ingested.

(5) Manufacture of tablets Tablets were manufactured according to the following composition.
Powdered composition of Example 1: 43 parts by weight Maltose: 25 parts by weight Dextrin: 30 parts by weight Calcium stearate: 2 parts by weight

(6) Production of cookies Cookies were produced according to the following composition. Cookies correspond to food and drink.
Powdered composition of Example 1: 1 part by weight Soft flour: 140 parts by weight Butter: 70 parts by weight Sugar: 35 parts by weight

(7) Manufacture of emulsion The emulsion was manufactured by the following mixing | blendings. Latex corresponds to cosmetics.
Powdered composition of Example 1: 1 part by weight Water: 100 parts by weight Orange flavor: 1 part by weight

(8) Manufacture of pet food Pet food was manufactured with the following composition.
Powdered composition of Example 1: 10 parts by weight Corn: 58 parts by weight Corn gluten: 5.5 parts by weight Chicken meal: 22 parts by weight Dried chicory: 2.5 parts by weight The rest: salt, vitamins and minerals Other Embodiments Although the embodiment of the present disclosure has been described above, the present disclosure is not limited to the above-described embodiment, and various modifications can be made.

  (1) A function of one component in each of the above embodiments may be shared by a plurality of components, or a function of a plurality of components may be exhibited by one component. Moreover, you may abbreviate | omit a part of structure of each said embodiment. In addition, at least a part of the configuration of each of the above embodiments may be added to or replaced with the configuration of the other above embodiments. In addition, all the aspects included in the technical idea specified from the wording described in the claims are embodiments of the present disclosure.

  (2) In addition to the powdery composition described above, various forms such as a system comprising the powdery composition as a constituent, a dry eye improving agent, a skin quality improving agent, food and drink, cosmetics, pet food production methods, etc. The present disclosure can also be realized.

Claims (12)

Functional oils and fats,
Modified starch,
Powdered medium,
Including
The powdery composition whose mass ratio of the mass of the said functional fat / oil with respect to the mass of the said powdery medium is 10 / 90-70 / 30. It is a powdery composition of Claim 1, Comprising:
The functional fat is one or more selected from the group consisting of glycerin fatty acid ester, tocopherol, β-carotene, lutein, β-cryptoxanthin, lycopene, and vitamin A,
The fatty acid chain in the glycerin fatty acid ester is a powder composition containing one or more selected from the group consisting of palmitoleic acid, palmitic acid, oleic acid, α-linolenic acid, stearic acid, eicosapentaenoic acid, and docosahexaenoic acid. The powder composition according to claim 1 or 2,
The said functional fats and oils are powdered compositions which are the fats and oils contained in a sea buckthorn. It is a powdery composition of any one of Claims 1-3,
The powdery medium is one or more powdery compositions selected from the group consisting of starch, calcium hydrogen phosphate, magnesium trisilicate, crystalline cellulose, lactose hydrate, and mannitol. A method for producing a powdery composition comprising:
Forming a wet mixture comprising functional oil, modified starch, powdered medium, and aqueous medium;
Removing the aqueous medium from the wet mixture;
The manufacturing method of the powdery composition whose mass ratio of the mass of the said functional fat / oil with respect to the mass of the said powdery medium is 10 / 90-70 / 30. It is a manufacturing method of the powdery composition of Claim 5,
The manufacturing method of the powdery composition whose median diameter in the said wet mixture is 50 micrometers or less. It is a manufacturing method of the powdery composition of Claim 5 or 6,
A method for producing a powdery composition, wherein the aqueous medium is removed from the wet mixture by a spray drying method, a fluidized bed granulation method, a heated vacuum drying method, or a freeze drying method.   The dry eye improving agent containing the powdery composition of any one of Claims 1-4.   The skin quality improving agent containing the powdery composition of any one of Claims 1-4.   Food / beverage products containing the powdery composition of any one of Claims 1-4.   Cosmetics containing the powdery composition of any one of Claims 1-4.   The pet food containing the powdery composition of any one of Claims 1-4.