CN1082952C - 吡咯基哌嗪基苯基噁唑烷酮抗微生物剂 - Google Patents

吡咯基哌嗪基苯基噁唑烷酮抗微生物剂 Download PDF

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Publication number
CN1082952C
CN1082952C CN97191516A CN97191516A CN1082952C CN 1082952 C CN1082952 C CN 1082952C CN 97191516 A CN97191516 A CN 97191516A CN 97191516 A CN97191516 A CN 97191516A CN 1082952 C CN1082952 C CN 1082952C
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CN
China
Prior art keywords
oxo
methyl
acetamide
piperazinyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97191516A
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English (en)
Chinese (zh)
Other versions
CN1206410A (zh
Inventor
R·C·盖得伍德
M·R·巴巴汉
D·S·图普斯
H·W·施密斯
V·A·瓦兰克特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of CN1206410A publication Critical patent/CN1206410A/zh
Application granted granted Critical
Publication of CN1082952C publication Critical patent/CN1082952C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN97191516A 1996-02-26 1997-02-18 吡咯基哌嗪基苯基噁唑烷酮抗微生物剂 Expired - Fee Related CN1082952C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1231696P 1996-02-26 1996-02-26
US60/012,316 1996-02-26

Publications (2)

Publication Number Publication Date
CN1206410A CN1206410A (zh) 1999-01-27
CN1082952C true CN1082952C (zh) 2002-04-17

Family

ID=21754387

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97191516A Expired - Fee Related CN1082952C (zh) 1996-02-26 1997-02-18 吡咯基哌嗪基苯基噁唑烷酮抗微生物剂

Country Status (18)

Country Link
US (1) US5736545A (enExample)
EP (1) EP0883611B1 (enExample)
JP (1) JP2000505084A (enExample)
KR (1) KR19990087238A (enExample)
CN (1) CN1082952C (enExample)
AT (1) ATE221521T1 (enExample)
AU (1) AU703831B2 (enExample)
DE (1) DE69714418T2 (enExample)
DK (1) DK0883611T3 (enExample)
ES (1) ES2180945T3 (enExample)
ID (1) ID18467A (enExample)
MY (1) MY116093A (enExample)
NZ (1) NZ331011A (enExample)
PE (1) PE55898A1 (enExample)
PT (1) PT883611E (enExample)
TW (1) TW442460B (enExample)
WO (1) WO1997030981A1 (enExample)
ZA (1) ZA971287B (enExample)

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GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
JP2002513424A (ja) * 1997-07-11 2002-05-08 ファルマシア・アンド・アップジョン・カンパニー チアジアゾリルおよびオキサジアゾリルフェニルオキサゾリジノン抗菌剤
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6239152B1 (en) 1998-01-23 2001-05-29 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CN1311787A (zh) 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物
WO2000007446A1 (de) * 1998-08-04 2000-02-17 Ciba Specialty Chemicals Holding Inc. Mikrobizide wirksubstanzen
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
AU6937001A (en) * 2000-07-17 2002-01-30 Ranbaxy Lab Ltd Oxazolidinone derivatives as antimicrobials
US6897230B2 (en) * 2001-04-17 2005-05-24 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof
EP1409464A4 (en) * 2001-07-16 2005-11-02 Ranbaxy Lab Ltd OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS
JP2005529924A (ja) * 2002-05-15 2005-10-06 ランバクシー ラボラトリーズ リミテッド フェニルオキサゾリジノン誘導体
EA200500283A1 (ru) * 2002-07-29 2005-08-25 Рэнбакси Лабораториз Лимитед Производные оксазолидинона как противомикробные средства
DE60304360T2 (de) 2002-08-12 2006-11-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-aryl-2-oxazolidinone und deren derivate
WO2004026848A1 (en) * 2002-09-20 2004-04-01 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
US7141570B2 (en) 2002-11-21 2006-11-28 Pharmacia & Upjohn Company N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US20060247286A1 (en) * 2003-07-02 2006-11-02 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
ATE471937T1 (de) * 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
WO2005051933A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
WO2005082899A1 (en) * 2004-01-28 2005-09-09 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
MY148480A (en) * 2004-05-24 2013-04-30 Amgen Inc Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2006035283A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006043121A1 (en) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006051408A1 (en) * 2004-11-11 2006-05-18 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
CN100406455C (zh) * 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
MX2009011416A (es) * 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
JP2010525013A (ja) * 2007-04-23 2010-07-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
CA2683111A1 (en) * 2007-04-23 2008-10-30 Janssen Pharmaceutica N.V. 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール
JP5417439B2 (ja) * 2008-07-03 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
CN102171189B (zh) * 2008-07-31 2013-11-20 詹森药业有限公司 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶
WO2011152442A1 (ja) * 2010-06-03 2011-12-08 塩野義製薬株式会社 2－クロロ－6－フルオロベンゾオキサゾールの製造方法
CN102079730B (zh) * 2010-09-06 2013-10-16 贵州大学 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用
CN103450173B (zh) * 2013-09-07 2015-06-03 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途
CN103709119B (zh) * 2013-12-04 2015-05-20 上海应用技术学院 一种制备5-氨基噻唑-4-甲酰胺的方法
CN104202835A (zh) * 2014-09-03 2014-12-10 苏州微站通信科技有限公司 Ue进入静默期时让基站及时释放时频资源的方法
CN112204017B (zh) * 2018-04-27 2024-08-20 国立大学法人大阪大学 苯并异噁唑化合物
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors

Citations (1)

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WO1995014684A1 (en) * 1993-11-22 1995-06-01 The Upjohn Company Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones

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US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
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Also Published As

Publication number Publication date
EP0883611B1 (en) 2002-07-31
AU703831B2 (en) 1999-04-01
WO1997030981A1 (en) 1997-08-28
ZA971287B (en) 1998-08-14
PE55898A1 (es) 1998-09-16
PT883611E (pt) 2002-12-31
US5736545A (en) 1998-04-07
ID18467A (id) 1998-04-09
EP0883611A1 (en) 1998-12-16
CN1206410A (zh) 1999-01-27
HK1017033A1 (en) 1999-11-12
KR19990087238A (ko) 1999-12-15
ES2180945T3 (es) 2003-02-16
JP2000505084A (ja) 2000-04-25
DE69714418D1 (de) 2002-09-05
ATE221521T1 (de) 2002-08-15
TW442460B (en) 2001-06-23
AU1954797A (en) 1997-09-10
DE69714418T2 (de) 2003-01-16
DK0883611T3 (da) 2002-12-02
NZ331011A (en) 2000-04-28
MY116093A (en) 2003-11-28

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