MY116093A - Azolyl piperazinyl phenyl oxazolidinone antimicrobials - Google Patents
Azolyl piperazinyl phenyl oxazolidinone antimicrobialsInfo
- Publication number
- MY116093A MY116093A MYPI97000373A MYPI19970373A MY116093A MY 116093 A MY116093 A MY 116093A MY PI97000373 A MYPI97000373 A MY PI97000373A MY PI19970373 A MYPI19970373 A MY PI19970373A MY 116093 A MY116093 A MY 116093A
- Authority
- MY
- Malaysia
- Prior art keywords
- carbon
- nitrogen
- azolyl
- piperazinyl phenyl
- phenyl oxazolidinone
- Prior art date
Links
- UBNIPSDNVLNRMR-UHFFFAOYSA-N 3-phenyl-4-piperazin-1-yl-4-(1h-pyrrol-2-yl)-1,3-oxazolidin-2-one Chemical compound O=C1OCC(C=2NC=CC=2)(N2CCNCC2)N1C1=CC=CC=C1 UBNIPSDNVLNRMR-UHFFFAOYSA-N 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 AZOLYL Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 abstract 1
- HHRFWSALGNYPHA-UHFFFAOYSA-N [N].C1CNCCN1 Chemical group [N].C1CNCCN1 HHRFWSALGNYPHA-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1231696P | 1996-02-26 | 1996-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY116093A true MY116093A (en) | 2003-11-28 |
Family
ID=21754387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI97000373A MY116093A (en) | 1996-02-26 | 1997-01-31 | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5736545A (enExample) |
| EP (1) | EP0883611B1 (enExample) |
| JP (1) | JP2000505084A (enExample) |
| KR (1) | KR19990087238A (enExample) |
| CN (1) | CN1082952C (enExample) |
| AT (1) | ATE221521T1 (enExample) |
| AU (1) | AU703831B2 (enExample) |
| DE (1) | DE69714418T2 (enExample) |
| DK (1) | DK0883611T3 (enExample) |
| ES (1) | ES2180945T3 (enExample) |
| ID (1) | ID18467A (enExample) |
| MY (1) | MY116093A (enExample) |
| NZ (1) | NZ331011A (enExample) |
| PE (1) | PE55898A1 (enExample) |
| PT (1) | PT883611E (enExample) |
| TW (1) | TW442460B (enExample) |
| WO (1) | WO1997030981A1 (enExample) |
| ZA (1) | ZA971287B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| CA2294293A1 (en) * | 1997-07-11 | 1999-01-21 | Pharmacia & Upjohn Company | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| CA2318969A1 (en) * | 1998-01-23 | 1999-07-29 | Mikhail F. Gordeev | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| EP1082323A2 (en) * | 1998-06-05 | 2001-03-14 | AstraZeneca UK Limited | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| US6689372B1 (en) * | 1998-08-04 | 2004-02-10 | Ciba Specialty Chemicals Corporation | Microbicidal active substances |
| AU4224699A (en) | 1999-01-27 | 2000-08-18 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2002006278A1 (en) * | 2000-07-17 | 2002-01-24 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2003008389A1 (en) * | 2001-07-16 | 2003-01-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as potential antimicrobials |
| ES2248633T3 (es) * | 2001-04-17 | 2006-03-16 | MERCK & CO., INC. | Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos. |
| CA2483600A1 (en) * | 2002-05-15 | 2003-11-27 | Ranbaxy Laboratories Limited | Polymorphic forms of phenyl oxazolidinone derivatives |
| BR0215921A (pt) * | 2002-07-29 | 2005-09-13 | Ranbaxy Lab Ltd | Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação |
| MXPA05001558A (es) | 2002-08-12 | 2005-09-08 | Pharmacia & Upjohn Co Llc | N-aril-2-oxazolidinonas y sus derivados. |
| WO2004026848A1 (en) * | 2002-09-20 | 2004-04-01 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| ATE344036T1 (de) | 2002-11-21 | 2006-11-15 | Pharmacia & Upjohn Co Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel |
| US20070293493A1 (en) * | 2003-07-02 | 2007-12-20 | Milton Hammond | Oxazolidinone antibiotics and derivatives thereof |
| AU2004256085B2 (en) * | 2003-07-02 | 2007-12-06 | Kyorin, Pharmaceutical Co., Ltd. | Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof |
| CA2529292A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| MXPA06000228A (es) * | 2003-07-02 | 2006-06-27 | Merck & Co Inc | Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos. |
| WO2005051933A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby |
| WO2005082899A1 (en) * | 2004-01-28 | 2005-09-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| AU2005247929B2 (en) * | 2004-05-24 | 2010-03-11 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| US8686011B2 (en) | 2004-05-24 | 2014-04-01 | Amgen Inc. | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| WO2006035283A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) * | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006051408A1 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US20090018123A1 (en) * | 2005-06-20 | 2009-01-15 | Milind D Sindkhedkar | Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| CN100406455C (zh) * | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JP5431305B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体 |
| RU2489431C2 (ru) * | 2007-04-23 | 2013-08-10 | Янссен Фармацевтика Н.В. | Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2 |
| AU2008240727C1 (en) * | 2007-04-23 | 2013-10-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| CN101965353B (zh) * | 2008-03-26 | 2014-12-17 | 丹诺医药(苏州）有限公司 | 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类 |
| JP5417439B2 (ja) * | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類 |
| EA019048B1 (ru) * | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
| WO2011152442A1 (ja) * | 2010-06-03 | 2011-12-08 | 塩野義製薬株式会社 | 2－クロロ－6－フルオロベンゾオキサゾールの製造方法 |
| CN102079730B (zh) * | 2010-09-06 | 2013-10-16 | 贵州大学 | 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用 |
| CN103450173B (zh) * | 2013-09-07 | 2015-06-03 | 吉首大学 | 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途 |
| CN103709119B (zh) * | 2013-12-04 | 2015-05-20 | 上海应用技术学院 | 一种制备5-氨基噻唑-4-甲酰胺的方法 |
| CN104202835A (zh) * | 2014-09-03 | 2014-12-10 | 苏州微站通信科技有限公司 | Ue进入静默期时让基站及时释放时频资源的方法 |
| CN112204017B (zh) * | 2018-04-27 | 2024-08-20 | 国立大学法人大阪大学 | 苯并异噁唑化合物 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| NZ274966A (en) * | 1993-11-22 | 1998-01-26 | Upjohn Co | Substituted-hydroxyacetyl piperazine phenyl oxazolidinone derivatives, use in pharmaceutical compositions |
-
1997
- 1997-01-31 MY MYPI97000373A patent/MY116093A/en unknown
- 1997-02-14 ZA ZA971287A patent/ZA971287B/xx unknown
- 1997-02-18 AT AT97907574T patent/ATE221521T1/de not_active IP Right Cessation
- 1997-02-18 CN CN97191516A patent/CN1082952C/zh not_active Expired - Fee Related
- 1997-02-18 DK DK97907574T patent/DK0883611T3/da active
- 1997-02-18 ES ES97907574T patent/ES2180945T3/es not_active Expired - Lifetime
- 1997-02-18 KR KR1019980706639A patent/KR19990087238A/ko not_active Abandoned
- 1997-02-18 NZ NZ331011A patent/NZ331011A/xx unknown
- 1997-02-18 JP JP9530192A patent/JP2000505084A/ja not_active Withdrawn
- 1997-02-18 PE PE1997000112A patent/PE55898A1/es not_active Application Discontinuation
- 1997-02-18 WO PCT/US1997/001970 patent/WO1997030981A1/en not_active Ceased
- 1997-02-18 PT PT97907574T patent/PT883611E/pt unknown
- 1997-02-18 AU AU19547/97A patent/AU703831B2/en not_active Ceased
- 1997-02-18 DE DE69714418T patent/DE69714418T2/de not_active Expired - Fee Related
- 1997-02-18 EP EP97907574A patent/EP0883611B1/en not_active Expired - Lifetime
- 1997-02-20 US US08/803,469 patent/US5736545A/en not_active Expired - Fee Related
- 1997-02-21 TW TW086102075A patent/TW442460B/zh not_active IP Right Cessation
- 1997-02-24 ID IDP970548A patent/ID18467A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0883611B1 (en) | 2002-07-31 |
| ID18467A (id) | 1998-04-09 |
| TW442460B (en) | 2001-06-23 |
| DK0883611T3 (da) | 2002-12-02 |
| HK1017033A1 (en) | 1999-11-12 |
| JP2000505084A (ja) | 2000-04-25 |
| NZ331011A (en) | 2000-04-28 |
| PT883611E (pt) | 2002-12-31 |
| AU703831B2 (en) | 1999-04-01 |
| ZA971287B (en) | 1998-08-14 |
| DE69714418D1 (de) | 2002-09-05 |
| ES2180945T3 (es) | 2003-02-16 |
| EP0883611A1 (en) | 1998-12-16 |
| DE69714418T2 (de) | 2003-01-16 |
| WO1997030981A1 (en) | 1997-08-28 |
| US5736545A (en) | 1998-04-07 |
| CN1206410A (zh) | 1999-01-27 |
| AU1954797A (en) | 1997-09-10 |
| ATE221521T1 (de) | 2002-08-15 |
| CN1082952C (zh) | 2002-04-17 |
| PE55898A1 (es) | 1998-09-16 |
| KR19990087238A (ko) | 1999-12-15 |
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