CA2243706A1 - Azolyl piperazinyl phenyl oxazolidinone antimicrobials - Google Patents
Azolyl piperazinyl phenyl oxazolidinone antimicrobialsInfo
- Publication number
- CA2243706A1 CA2243706A1 CA002243706A CA2243706A CA2243706A1 CA 2243706 A1 CA2243706 A1 CA 2243706A1 CA 002243706 A CA002243706 A CA 002243706A CA 2243706 A CA2243706 A CA 2243706A CA 2243706 A1 CA2243706 A1 CA 2243706A1
- Authority
- CA
- Canada
- Prior art keywords
- carbon
- azolyl
- nitrogen
- piperazinyl phenyl
- phenyl oxazolidinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UBNIPSDNVLNRMR-UHFFFAOYSA-N 3-phenyl-4-piperazin-1-yl-4-(1h-pyrrol-2-yl)-1,3-oxazolidin-2-one Chemical compound O=C1OCC(C=2NC=CC=2)(N2CCNCC2)N1C1=CC=CC=C1 UBNIPSDNVLNRMR-UHFFFAOYSA-N 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- HHRFWSALGNYPHA-UHFFFAOYSA-N [N].C1CNCCN1 Chemical group [N].C1CNCCN1 HHRFWSALGNYPHA-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003943 azolyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compounds useful in the preparation of pharmaceutical preparations for the treatment of microbial infection where such compounds are of structural formula (I) or pharmaceutically acceptable salts thereof wherein: R1 is -CHO, -COCH3, -COCHCl2, -COCHF2, -CO2CH3, -SO2CH3, or -COCH2OH; X1 and X2 are independently H, F, or Cl; and Q is a five-membered ring heterocycle (azolyl ring) of general form (a) wherein A, B, and C, are independently oxygen (O), nitrogen (N), sulfur (S) or carbon (C). In all cases, the piperazine nitrogen atom is attached at the carbon atom of the carbon-nitrogen double bond.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1231696P | 1996-02-26 | 1996-02-26 | |
| US60/012,316 | 1996-02-26 | ||
| PCT/US1997/001970 WO1997030981A1 (en) | 1996-02-26 | 1997-02-18 | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2243706A1 true CA2243706A1 (en) | 1997-08-28 |
| CA2243706C CA2243706C (en) | 2005-10-04 |
Family
ID=35395933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002243706A Expired - Fee Related CA2243706C (en) | 1996-02-26 | 1997-02-18 | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2243706C (en) |
-
1997
- 1997-02-18 CA CA002243706A patent/CA2243706C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2243706C (en) | 2005-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |