PE55898A1 - Antimicrobianos de azolilpiperazinilfeniloxazolidinona - Google Patents
Antimicrobianos de azolilpiperazinilfeniloxazolidinonaInfo
- Publication number
- PE55898A1 PE55898A1 PE1997000112A PE00011297A PE55898A1 PE 55898 A1 PE55898 A1 PE 55898A1 PE 1997000112 A PE1997000112 A PE 1997000112A PE 00011297 A PE00011297 A PE 00011297A PE 55898 A1 PE55898 A1 PE 55898A1
- Authority
- PE
- Peru
- Prior art keywords
- carbon
- nitrogen
- image
- azolyl
- independently
- Prior art date
Links
- UBNIPSDNVLNRMR-UHFFFAOYSA-N 3-phenyl-4-piperazin-1-yl-4-(1h-pyrrol-2-yl)-1,3-oxazolidin-2-one Chemical compound O=C1OCC(C=2NC=CC=2)(N2CCNCC2)N1C1=CC=CC=C1 UBNIPSDNVLNRMR-UHFFFAOYSA-N 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- HHRFWSALGNYPHA-UHFFFAOYSA-N [N].C1CNCCN1 Chemical group [N].C1CNCCN1 HHRFWSALGNYPHA-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003943 azolyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1231696P | 1996-02-26 | 1996-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE55898A1 true PE55898A1 (es) | 1998-09-16 |
Family
ID=21754387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000112A PE55898A1 (es) | 1996-02-26 | 1997-02-18 | Antimicrobianos de azolilpiperazinilfeniloxazolidinona |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5736545A (enExample) |
| EP (1) | EP0883611B1 (enExample) |
| JP (1) | JP2000505084A (enExample) |
| KR (1) | KR19990087238A (enExample) |
| CN (1) | CN1082952C (enExample) |
| AT (1) | ATE221521T1 (enExample) |
| AU (1) | AU703831B2 (enExample) |
| DE (1) | DE69714418T2 (enExample) |
| DK (1) | DK0883611T3 (enExample) |
| ES (1) | ES2180945T3 (enExample) |
| ID (1) | ID18467A (enExample) |
| MY (1) | MY116093A (enExample) |
| NZ (1) | NZ331011A (enExample) |
| PE (1) | PE55898A1 (enExample) |
| PT (1) | PT883611E (enExample) |
| TW (1) | TW442460B (enExample) |
| WO (1) | WO1997030981A1 (enExample) |
| ZA (1) | ZA971287B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| AU729745B2 (en) * | 1997-07-11 | 2001-02-08 | Pharmacia & Upjohn Company | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| WO1999037630A1 (en) * | 1998-01-23 | 1999-07-29 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| NZ508174A (en) | 1998-06-05 | 2003-10-31 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| DE59905341D1 (de) * | 1998-08-04 | 2003-06-05 | Ciba Sc Holding Ag | Verwendung von Oxathiazolonen als Mikrobizide |
| JP2002535680A (ja) | 1999-01-27 | 2002-10-22 | ファルマシア・アンド・アップジョン・カンパニー | 延長因子ｐ活性モジュレーターのアッセイ方法 |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| RU2292345C9 (ru) * | 2000-07-17 | 2007-05-10 | Ранбакси Лабораторис Лимитед | Производные оксазолидинона |
| WO2003008389A1 (en) * | 2001-07-16 | 2003-01-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as potential antimicrobials |
| ATE304536T1 (de) * | 2001-04-17 | 2005-09-15 | Merck & Co Inc | Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate |
| BR0310074A (pt) * | 2002-05-15 | 2005-03-08 | Ranbaxy Lab Ltd | Formas polimórficas de derivados de fenil oxazolidinona |
| CN1668308A (zh) * | 2002-07-29 | 2005-09-14 | 兰贝克赛实验室有限公司 | 作为抗菌剂的噁唑烷酮衍生物 |
| AU2003259159A1 (en) | 2002-08-12 | 2004-02-25 | Pharmacia & Upjohn Company Llc | N-aryl-2-oxazolidinones and their derivatives |
| AU2002339721A1 (en) * | 2002-09-20 | 2004-04-08 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| EP1565186B1 (en) | 2002-11-21 | 2006-11-02 | Pharmacia & Upjohn Company LLC | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
| JP2007521284A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | オキサゾリジノン系抗生物質及びその誘導体 |
| AU2004256084B2 (en) * | 2003-07-02 | 2007-10-18 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
| NZ544237A (en) * | 2003-07-02 | 2008-09-26 | Merck & Co Inc | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| JP2007521283A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体 |
| WO2005051933A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby |
| WO2005082899A1 (en) * | 2004-01-28 | 2005-09-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US20070281938A1 (en) * | 2004-05-24 | 2007-12-06 | Amgen Inc. | Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1 |
| US8686011B2 (en) | 2004-05-24 | 2014-04-01 | Amgen Inc. | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| WO2006035283A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) * | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006051408A1 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2007023507A2 (en) * | 2005-06-20 | 2007-03-01 | Wockhardt Limited | Oxazolidinones bearing antimicrobial activity composition and methods of preparation |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| CN100406455C (zh) * | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| US20100137368A1 (en) * | 2007-04-23 | 2010-06-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| WO2008128995A1 (en) * | 2007-04-23 | 2008-10-30 | Janssen Pharmaceutica N.V. | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| CA2712613C (en) * | 2008-03-26 | 2017-02-28 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| MX2011000043A (es) * | 2008-07-03 | 2011-02-22 | Janssen Pharmaceutica Nv | 6-(1-piperazinil)-piridazinas sustituidas como antagonistas del receptor 5-ht6. |
| HRP20170570T1 (hr) * | 2008-07-31 | 2017-06-16 | Janssen Pharmaceutica Nv | Piperazin-1-il-trifluormetil-supstituirani-piridini kao brzo disocirajući antagonisti receptora dopamina 2 |
| WO2011152442A1 (ja) * | 2010-06-03 | 2011-12-08 | 塩野義製薬株式会社 | 2－クロロ－6－フルオロベンゾオキサゾールの製造方法 |
| CN102079730B (zh) * | 2010-09-06 | 2013-10-16 | 贵州大学 | 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用 |
| CN103450173B (zh) * | 2013-09-07 | 2015-06-03 | 吉首大学 | 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途 |
| CN103709119B (zh) * | 2013-12-04 | 2015-05-20 | 上海应用技术学院 | 一种制备5-氨基噻唑-4-甲酰胺的方法 |
| CN104202835A (zh) * | 2014-09-03 | 2014-12-10 | 苏州微站通信科技有限公司 | Ue进入静默期时让基站及时释放时频资源的方法 |
| CN112204017B (zh) * | 2018-04-27 | 2024-08-20 | 国立大学法人大阪大学 | 苯并异噁唑化合物 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| WO1995014684A1 (en) * | 1993-11-22 | 1995-06-01 | The Upjohn Company | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
-
1997
- 1997-01-31 MY MYPI97000373A patent/MY116093A/en unknown
- 1997-02-14 ZA ZA971287A patent/ZA971287B/xx unknown
- 1997-02-18 WO PCT/US1997/001970 patent/WO1997030981A1/en not_active Ceased
- 1997-02-18 KR KR1019980706639A patent/KR19990087238A/ko not_active Abandoned
- 1997-02-18 PE PE1997000112A patent/PE55898A1/es not_active Application Discontinuation
- 1997-02-18 NZ NZ331011A patent/NZ331011A/xx unknown
- 1997-02-18 AU AU19547/97A patent/AU703831B2/en not_active Ceased
- 1997-02-18 EP EP97907574A patent/EP0883611B1/en not_active Expired - Lifetime
- 1997-02-18 DE DE69714418T patent/DE69714418T2/de not_active Expired - Fee Related
- 1997-02-18 AT AT97907574T patent/ATE221521T1/de not_active IP Right Cessation
- 1997-02-18 ES ES97907574T patent/ES2180945T3/es not_active Expired - Lifetime
- 1997-02-18 JP JP9530192A patent/JP2000505084A/ja not_active Withdrawn
- 1997-02-18 PT PT97907574T patent/PT883611E/pt unknown
- 1997-02-18 CN CN97191516A patent/CN1082952C/zh not_active Expired - Fee Related
- 1997-02-18 DK DK97907574T patent/DK0883611T3/da active
- 1997-02-20 US US08/803,469 patent/US5736545A/en not_active Expired - Fee Related
- 1997-02-21 TW TW086102075A patent/TW442460B/zh not_active IP Right Cessation
- 1997-02-24 ID IDP970548A patent/ID18467A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY116093A (en) | 2003-11-28 |
| DE69714418D1 (de) | 2002-09-05 |
| ATE221521T1 (de) | 2002-08-15 |
| US5736545A (en) | 1998-04-07 |
| AU1954797A (en) | 1997-09-10 |
| ZA971287B (en) | 1998-08-14 |
| ES2180945T3 (es) | 2003-02-16 |
| CN1206410A (zh) | 1999-01-27 |
| CN1082952C (zh) | 2002-04-17 |
| DK0883611T3 (da) | 2002-12-02 |
| AU703831B2 (en) | 1999-04-01 |
| EP0883611B1 (en) | 2002-07-31 |
| NZ331011A (en) | 2000-04-28 |
| EP0883611A1 (en) | 1998-12-16 |
| PT883611E (pt) | 2002-12-31 |
| TW442460B (en) | 2001-06-23 |
| KR19990087238A (ko) | 1999-12-15 |
| WO1997030981A1 (en) | 1997-08-28 |
| JP2000505084A (ja) | 2000-04-25 |
| DE69714418T2 (de) | 2003-01-16 |
| HK1017033A1 (en) | 1999-11-12 |
| ID18467A (id) | 1998-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |