CN108261498A - 一种清肺润肺的组合物 - Google Patents
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Abstract
本发明公开了一种润肺的组合物，它是由下述重量配比的原料制备而成的制剂：麦冬须根80～120份、百合80～120份、桑叶40～60份、薄荷9.6～14.4份、人参0.8～1.2份。该组合物以《医方集解》中医名方百合固金汤为基础方加减变化而来，具有清肺润肺护肺的作用。本发明还通过对处方及工艺条件的考察，将上述组合物进一步制备成液体饮料。感官评价实验表明，本发明液体饮料口感、色泽及香味俱佳，受试人员评价普遍较好。而且，该饮料具有清肺润肺功能，能有效预防因工作或生活在空气污染严重、粉尘多或烟草燃烧等带来的不良反应，具有广阔的市场前景。
Description
技术领域
本发明涉及一种清肺润肺的组合物，属于医药领域。
背景技术
肺为娇脏，不耐寒热，喜润而恶燥。现代气候变化，环境污染，肺遭受大气变化，首先受伤，会导致咳喘等病症，继而影响多个器官，导致身体健康异常。养肺润肺是保养身体预防疾病的关键。因此，提供一种清肺润肺的组合物，具有重要意义。
发明内容
本发明的目的在于提供一种清肺润肺的组合物。
本发明提供了一种润肺的组合物，它是由下述重量配比的原料制备而成的制剂：麦冬须根80～120份、百合80～120份、桑叶40～60份、薄荷9.6～14.4份、人参0.8～1.2份。
进一步地，它是由下述重量配比的原料制备而成的制剂：麦冬须根100份、百合100份、桑叶50份、薄荷12份、人参1份。
进一步地，它是由各重量配比原料的原生粉、水或有机溶剂的提取物，加入药学上、保健品中可接受的辅料或者辅助性成分制备而成的制剂。
进一步地，所述的制剂为口服制剂。
进一步地，所述的制剂为散剂、颗粒剂、胶囊剂、片剂、丸剂、茶剂、冲剂或液体饮料。
进一步地，所述液体饮料每1mL对应原料0.0526g。
本发明提供了一种所述组合物的制备方法，包括如下步骤：取各重量配比的原料，直接打粉，或者加入水或有机溶剂提取，再加入药学上、保健品中可接受的辅料或者辅助性成分，即得。
进一步地，所述的制备方法包括如下步骤：取各重量配比的原料，加10倍体积量水煎煮30分钟，过滤，滤液备用；药渣加8倍体积量水煎煮30分钟，过滤，合并两次滤液，即得。
进一步地，所述的制备方法还包括如下步骤：浓缩滤液，加水稀释至每1mL对应原料0.0526g，制成糖度为0～8.8的溶液，即得液体饮料。
本发明提供了所述组合物在制备清肺、润肺的药物或保健品中的用途。
本发明提供了一种清肺润肺的组合物。该组合物以《医方集解》中医名方百合固金汤为基础方加减变化而来。方中麦冬须根类似麦冬，味甘、寒润，生津、润肺养胃，为君药；百合苦甘，清心又养肺阴，为臣药；桑叶清肺热又降肝火，为佐药；薄荷清热，引药入肺又舒达肝气，避免肝火犯肺，为使药；同时佐以适量人参，取人参益气、生津的作用。诸药协作，具有清肺润肺护肺的作用，效果优于百合固金汤。
本发明还通过对处方及工艺条件的考察，将上述组合物进一步制备成液体饮料。感官评价实验表明，本发明液体饮料口感、色泽及香味俱佳，受试人员评价普遍较好。而且，该饮料具有清肺润肺功能，能有效预防因工作或生活在空气污染严重、粉尘多或烟草燃烧等带来的不良反应，具有广阔的市场前景。
显然，根据本发明的上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
附图说明
图1为本发明液体饮料生产工艺流程图。
具体实施方式
本发明具体实施方式中使用的原料、设备均为已知产品，通过购买市售产品获得。
实施例1本发明液体饮料的制备
处方：麦冬须根100g、百合100g、桑叶50g、薄荷12g、人参1g
制备工艺：
(一)浓溶液制备
取药材，第一次加10倍体积量水，浸泡半小时，大火煮开后改小火30分钟，过滤，滤液备用；第二次加8倍体积量水，大火煮开后改小火30分钟，过滤，合并两次滤液，浓缩成500ml，制备得到每1mL对应原料0.526g的浓溶液。
(二)液体饮料制备
取上述浓溶液，用纯净水等比例稀释10倍(每1mL对应原料0.0526g)，加白砂糖，制成糖度0～8.8(即每立方米加糖0kg-90kg，代用糖按甜度比例进行添加)的溶液，即得本发明组合物的液体饮料。
本发明液体饮料为琥珀色澄明液体，味微甜，可直接饮用。
以下通过实验例证明本发明的有益效果。
实验例1原料用量对本发明组合物口感、色泽及香味的影响
本实验设置6个实验组，分别按表1所示用量称取各原料，根据实施例1工艺制备成液体饮料。
随机选取200名受试者，均试喝6种组方饮料，分别从口感、色泽、香味方面进行综合评判。
表1原料处方
| 序号 | 麦冬须根/g | 百合/g | 桑叶/g | 薄荷/g | 人参/g | 喜好人数 |
| 1 | 100 | 100 | 50 | 12 | 1 | 87 |
| 2 | 100 | 100 | 80 | 50 | 1 | 15 |
| 3 | 100 | 100 | 100 | 50 | 1 | 26 |
| 4 | 100 | 100 | 50 | 50 | 1 | 35 |
| 5 | 100 | 100 | 50 | 20 | 1 | 20 |
| 6 | 100 | 100 | 50 | 5 | 1 | 17 |
实验结果：受试者中有87人认为1号组方更优，有15人认为2号组方更优，有26人认为3号组方更优，有35人认为4号组方更优，有20人认为5号组方更优，有17人认为6号组方更优。
以上结果表明，根据本发明组合物用量制备的液体饮料口感、色泽、香味等综合评价结果最优；在此基础上，改变桑叶和/或薄荷的用量，会导致本发明液体饮料感官评价的显著下降。
实验例2饮料浓度对本发明组合物口感、色泽及香味的影响
本实验设置4个实验组，根据实施例1工艺将本发明组合物制备成浓溶液；分别稀释成表2所示浓度的液体饮料。
随机选取150名受试者，均试喝4种不同浓度的液体饮料，分别从口感、色泽、香味方面进行综合评判。
表2液体饮料浓度
对比结果：有92人认为1号浓度更优，有35人认为2号组方更优，有15人认为3号组方更优，有8人认为4号组方更优。
以上结果表明，本发明液体饮料浓度为每1mL对应原料0.0526g时，饮料的口感、色泽、香味等综合评价结果最优；若增加或降低其浓度，均导致感官评价的显著下降。
实验例3原料提取方法对提取物得率的影响
| 序号 | 提取方法 | 提取物得率 |
| 1 | 实施例1提取方法 | 45％ |
| 2 | 100℃沸水冲泡1小时，浓缩 | 27％ |
| 3 | 40℃水冲泡1小时，浓缩 | 18％ |
| 4 | 25℃水冲泡1小时，浓缩 | 11％ |
实验结果：采用本发明实施例1提取方法提取最为充分，提取物得率达到45％；采用其它提取工艺均不能得到与本发明相当的提取效果。
Claims (10)
1.一种润肺的组合物，其特征是：它是由下述重量配比的原料制备而成的制剂：麦冬须根80～120份、百合80～120份、桑叶40～60份、薄荷9.6～14.4份、人参0.8～1.2份。
2.如权利要求1所述的组合物，其特征是：它是由下述重量配比的原料制备而成的制剂：麦冬须根100份、百合100份、桑叶50份、薄荷12份、人参1份。
3.如权利要求1或2所述的组合物，其特征是：它是由各重量配比原料的原生粉、水或有机溶剂的提取物，加入药学上、保健品中可接受的辅料或者辅助性成分制备而成的制剂。
4.如权利要求3所述的组合物，其特征是：所述的制剂为口服制剂。
5.如权利要求4所述的组合物，其特征是：所述的制剂为散剂、颗粒剂、胶囊剂、片剂、丸剂、茶剂、冲剂或液体饮料。
6.如权利要求5所述的组合物，其特征是：所述液体饮料每1mL对应原料0.0526g。
7.一种权利要求1～6任意一项所述组合物的制备方法，其特征是：包括如下步骤：取各重量配比的原料，直接打粉，或者加入水或有机溶剂提取，再加入药学上、保健品中可接受的辅料或者辅助性成分，即得。
8.如权利要求6所述的制备方法，其特征是：包括如下步骤：取各重量配比的原料，加10倍体积量水煎煮30分钟，过滤，滤液备用；药渣加8倍体积量水煎煮30分钟，过滤，合并两次滤液，即得。
9.如权利要求7所述的制备方法，其特征是：还包括如下步骤：浓缩滤液，加水稀释至每1mL对应原料0.0526g，制成糖度为0～8.8的溶液，即得液体饮料。
10.权利要求1～5任意一项所述组合物在制备清肺、润肺的药物或保健品中的用途。
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