CN108168986A - Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method - Google Patents
Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method Download PDFInfo
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- CN108168986A CN108168986A CN201810237229.5A CN201810237229A CN108168986A CN 108168986 A CN108168986 A CN 108168986A CN 201810237229 A CN201810237229 A CN 201810237229A CN 108168986 A CN108168986 A CN 108168986A
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- dyeing
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- 239000007788 liquid Substances 0.000 title claims abstract description 67
- 238000004043 dyeing Methods 0.000 title claims abstract description 64
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 15
- 238000004040 coloring Methods 0.000 title claims abstract description 8
- 239000002699 waste material Substances 0.000 claims abstract description 26
- 238000005119 centrifugation Methods 0.000 claims abstract description 10
- 239000000758 substrate Substances 0.000 claims description 19
- 239000011521 glass Substances 0.000 claims description 13
- 239000000945 filler Substances 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 8
- 230000033001 locomotion Effects 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 2
- 238000012216 screening Methods 0.000 abstract description 6
- 206010028980 Neoplasm Diseases 0.000 abstract description 5
- 201000011510 cancer Diseases 0.000 abstract description 5
- 230000002485 urinary effect Effects 0.000 abstract description 5
- 210000002700 urine Anatomy 0.000 abstract description 5
- 238000001514 detection method Methods 0.000 abstract description 4
- 230000003902 lesion Effects 0.000 abstract description 2
- 230000000116 mitigating effect Effects 0.000 abstract description 2
- 238000011079 streamline operation Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 21
- 238000010586 diagram Methods 0.000 description 12
- 230000005540 biological transmission Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 4
- 239000000975 dye Substances 0.000 description 3
- 238000000703 high-speed centrifugation Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 230000005693 optoelectronics Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Abstract
A kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method, the all-in-one machine includes rack, several photo making cups, several specimen cups and several suction nozzles with film-making chamber and sample chamber, further includes to pick up suction nozzle and sample is transferred to sample filling mechanical arm, two-in-one mechanical arm from discharge waste liquid to photo making cup, the temperature control mechanism and control device for controlling the film-making chamber temperature for filling dyeing liquor and of corresponding photo making cup from specimen cup.This method includes being transferred to photo making cup, centrifugation film-making and centrifugation dyeing by above-mentioned all-in-one machine automatic benchmarking this centrifugal concentrating, by sample.The present invention realizes the automatic streamline operation of sample concentration, sample-adding, film-making and dyeing.It can be applied to urinary cancer screening, human error caused by mitigating the hand labor intensity in urinary cancer screening significantly and reducing, human resources are saved, the unitized and standardization of urine liquid-based detection film-making dyeing is realized, improves urine lesion screening recall rate.
Description
Technical field
The present invention relates to liquid-based cell sample manufacturing dyeing installation and method more particularly to a kind of full-automatic liquid-based cell sample manufacturing dyes
Color all-in-one machine and film-making colouring method.
Background technology
In detection field is dyed in current urinary cancer early screening film-making, there are the automation of film-making staining instruments not
The shortcomings that high, most step manual operationss, process is cumbersome, time-consuming and laborious.Full automatic urine liquid-based film-making dyeing, which has, to be studied, but
It is not yet examined by industrialization, in the market currently without the professional equipment of this respect.
Invention content
The object of the present invention is to provide a kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring methods.
In order to achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, including：
Rack (10), including the film-making chamber (11) with the first turntable (111), with the film-making chamber side by side with second turn
The sample chamber (12) and the driving mechanism of first turntable and the second turntable (114,123) of disk (121)；
Several photo making cups (112) are arranged on first turntable (111)；
Several specimen cups (122) are arranged on second turntable (121)；
Several suction nozzles (113)；
For picking up suction nozzle and sample being transferred to the sample filling mechanical arm (20) of corresponding photo making cup from specimen cup；
For filling dyeing liquor into photo making cup and discharging the two-in-one mechanical arm (30) of waste liquid；
For controlling the temperature control mechanism (40) of the film-making chamber temperature；And
Control device (50), is used for：Control first turntable, the second turntable, sample filling mechanical arm and two-in-one machine
Tool arm presses program work, and the sample in specimen cup is carried out centrifugal concentrating, corresponding photo making cup is transferred to, is then centrifuged for film-making
And dyeing.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that the sample filling mechanical arm (20)
Including：
Sample filling component (21), the component have inner tube (212) and outer tube (213), and the lower end setting of said inner tube is inhaled
Mouth bindiny mechanism (211), upper end are fixedly connected with the first sliding block (215), and inner tube is also associated with tracheae for being inhaled by pressure control
Mouth sucks or discharge sample, and the outer tube sleeve is set on the periphery of said inner tube, and the upper end of outer tube passes through first sliding block and one
Locating part (217) is opposite to be used to control the outer tube and the opposite fortune of said inner tube after said inner tube moves upward to certain position
Dynamic that the suction nozzle for being connected to said inner tube lower end is made to come off, which also has the elastic component (216) that the outer tube is driven to reset；
First cantilever (22), for the sample to be filled modular support in main support (60)；
First driving mechanism (23), for first sliding block (215) to be driven to move up and down；And
Second driving mechanism (24), for first cantilever motion to be driven to position sample filling component to specified
Position.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that two-in-one mechanical arm (30) packet
It includes：
Work head assembly (31), the component have waste liquid suction pipe (313), at least one dyeing liquor filler pipe (312) and
Combination head (311), it is described for installing that the combination head is provided with several receiving holes (310) parallel with the axis of the combination head
Waste liquid suction pipe and at least one dyeing liquor filler pipe；
Second cantilever (32), for the work head assembly to be supported in main support (60)；
Third driving mechanism (33), for the work head assembly to be driven to move up and down；And
4th driving mechanism (34), for second cantilever motion to be driven to position the work head assembly to specific bit
It puts.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that in several receiving holes (310)
One receiving hole is located at the center of the combination head (311) end face, remaining receiving hole is distributed in and is held with the combination head (311)
The center in face is on the circumference in the center of circle, the waste liquid suction pipe (313) is installed in the receiving hole at center.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that the sample filling mechanical arm and institute
It states two-in-one mechanical arm and is installed on rack by combining installing mechanism, the combination installing mechanism includes being arranged on above workbench
Main support (60) and the combination bearing (70) that is arranged on the main support, the combination bearing include tubular base
(72), the tubular outer shaft (71) being sheathed on outside the tubular base and the inner shaft (73) being inserted in the tubular base, it is described
Tubular base (72) is installed in the main support (60), and the sample filling mechanical arm and the two-in-one mechanical arm correspondence pass through
First cantilever (22) and the second cantilever (32) are installed in the inner shaft (73) and the outer shaft (71).
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that each photo making cup (112) includes
Third substrate (1121), the collector tube (1124) for being arranged on the third substrate side and be inserted in the third substrate and with
The glass slide (1125) of collector tube connection, several photo making cup holding tanks of setting at the outer of first turntable (111)
(1111), several photo making cup correspondences are installed in several photo making cup holding tanks is pivotally connected with the side wall of place holding tank,
The glass slide of photo making cup is transversely supported on first turntable.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that first turntable (111) is static
Under state, the glass slide (1125) of photo making cup has the angle of 1 to 8 degree between horizontal plane.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that the driving of second turntable (121)
Mechanism (123) includes two motors (1231,1234), and one of motor is for driving the second turntable high-speed rotation, separately
One motor positions target specimen cup to designated position for second turntable to be driven to slowly run.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that the shaft of second turntable (121)
Unilateral bearing (1233) is set, another described motor drives second turntable (121) by the unilateral bearing.
In above-mentioned full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it is preferable that the temperature control mechanism (40) includes：
Heat source has a cool-bag (42) and the heater element (41) being set in the cool-bag；
The hot blast pipe (45) and backwind tube (44) being arranged between the heat source and the film-making chamber；
Power source (43), for drive the thermal energy that the heat source generates through the hot blast pipe enter the film-making chamber and
The air return of the film-making intracavitary is driven to the cool-bag (42)；
Temperature inductor, for detecting the temperature of the film-making intracavitary；And
Controller, for acquiring the temperature of the output valve of the temperature inductor and then the control film-making intracavitary.
A kind of full-automatic liquid-based cell sample manufacturing colouring method, uses the Full Automatic Liquid basal cell described in above-mentioned any one
All-in-one machine is dyed in film-making, and this method includes the following steps：
The second turntable high-speed rotation is controlled to concentrate specimen centrifuge；
First turntable and the second turntable are located in designated position；
Sample shifts：Sample filling mechanical arm picks up new suction nozzle, draws sample and is transferred in the photo making cup of working position, then
Remove suction nozzle；
Next specimen cup and photo making cup are turned into working position, repeat above-mentioned sample transfer step；It is complete to repeat the step
It is shifted into sample；
Centrifuge film-making；And
Coloring agent fills each photo making cup by two-in-one mechanical arm, centrifugation dyeing is discharged by two-in-one mechanical arm
Waste liquid in photo making cup.
Compared with prior art, the present invention at least has the advantages that：
Realize the automatic streamline operation of sample concentration, sample-adding, film-making and dyeing.It can be applied to urinary cancer sieve
It looks into, the human error caused by mitigating the hand labor intensity in urinary cancer screening significantly and reducing saves manpower
Resource realizes the unitized and standardization of urine liquid-based detection film-making dyeing, improves urine lesion screening recall rate.
Description of the drawings
Fig. 1 is the complete machine schematic diagram that the full-automatic liquid-based cell sample manufacturing of some embodiments dyes all-in-one machine；
Fig. 2 is its internal structure schematic diagram；
Fig. 3 is the structure diagram of two mechanical arm；
Fig. 4 is the schematic cross-sectional view that sample fills mechanical arm；
Fig. 5 is the structure diagram of work head assembly in two-in-one mechanical arm；
Fig. 6 is the internal structure schematic diagram of work head assembly in two-in-one mechanical arm；
Fig. 7 is the structure diagram of the combination installing mechanism of two mechanical arms；
Fig. 8 is the structure diagram of photo making cup；
Fig. 9 is the decomposing state figure of photo making cup；
Figure 10 is the structure diagram of the first turntable；
Figure 11 is the combination diagram on photo making cup and the first turntable；
Figure 12 is the combination diagram on specimen cup and the second turntable；
Figure 13 is the structure diagram of the driving mechanism of the second turntable；
Figure 14 is the structure diagram of temperature control mechanism.
Specific embodiment
The present invention will be further described with reference to the accompanying drawings and examples.
Referring to Figures 1 and 2, the full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine of some embodiments includes rack 10, rack 10
With sample chamber 12 and film-making chamber 11 arranged side by side, the first turntable 111 is provided in film-making chamber 11, is provided in sample chamber 12
Second turntable 121, rack 10 are additionally provided with the driving mechanism 123 of 114 and second turntable 121 of driving mechanism of the first turntable 111.
Film-making chamber 11 and sample chamber 12 are further provided with chamber lid 11 ' and 12 '.Rack 10 is further provided with holding for placing dyeing liquor
Receiving lattice 13, display device 14, emergency switch 15, waste collection chamber 16 and the control device 50 of device.Wherein, 14 He of display device
Control device 50 is using the device to become one, such as the programmable logic controller (PLC) (PLC) with display.
The full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine of some embodiments further includes：Several specimen cups 122, several photo making cups
112nd, several suction nozzles 113, add for picking up suction nozzle 113 and sample being transferred to the sample of corresponding photo making cup 112 from specimen cup 122
Note mechanical arm 20, the two-in-one mechanical arm 30 for filling dyeing liquor and absorption discharge waste liquid into photo making cup 112.If exsiccata
Cup 122 is arranged on the second turntable 121 in sample chamber 12, for storing pending sample.Several photo making cups 112 are arranged on
On the first turntable 111 in film-making chamber 11, for carrying out film-making and dyeing processing to sample.Several suction nozzles 113 are arranged on first
It on turntable 111, is combined by filling mechanical arm 20 with sample, to draw specimen fluids, sample filling mechanical arm 20 has handled one
After sample in a specimen cup 122, suction nozzle can be replaced automatically, so as to avoid the friendship between sample while automatic business processing is realized
Fork influences.
The full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine of some embodiments further includes temperature control mechanism 40, temperature control mechanism 40 and institute
It states film-making chamber 11 to connect, to maintain the temperature in film-making chamber 11 in the temperature of setting.
Control device 50 is used for：Control the first turntable 111, the second turntable 121, sample filling mechanical arm 20, two-in-one machine
Tool arm 30 presses program work, carries out centrifugal concentrating to the sample in specimen cup 122 first, transfers to corresponding photo making cup 112,
It is then centrifuged for film-making and dyeing.Specific process includes：Second turntable first, 121 high-speed rotation, in each specimen cup 122
Sample carries out centrifugal concentrating, next, draw the waste liquid at the middle and upper levels of specimen cup 122 by two-in-one mechanical arm 30, then sample
Filling mechanical arm 20 picks up the sample that suction nozzle 113 is drawn from specimen cup 122 after concentration and is transferred in photo making cup 112, at every place
After having managed a sample, suction nozzle is dropped into waste collection chamber 16 automatically, then picks up new suction nozzle and handles next sample, until
Sample transfer finishes, and following first turntable 111 rotates, and carries out centrifugation film-making, then by two-in-one mechanical arm 30 to film-making
Cup 112 injects dyeing liquor, centrifugation dyeing, then is discharged the waste liquid in photo making cup by two-in-one mechanical arm 30, finally in film-making
Film-making is completed on the wave carrier piece of cup.
Fig. 2 to Fig. 4 is please referred to, sample filling mechanical arm 20 includes：Sample fills component 21, and the first cantilever 22, first drives
23 and second driving mechanism 24 of motivation structure.
Wherein, sample filling component 21 has inner tube 212 and outer tube 213, and the lower end setting suction nozzle of said inner tube 212 connects
Mechanism 211, upper end are fixedly connected with the first sliding block 215, and the inner cavity 214 of inner tube 212 is also connected with tracheae (not shown), the tracheae
The suction nozzle for being connected to suction nozzle bindiny mechanism 211 with air source is connect, sucks or discharge sample by pressure control suction nozzle.It is described outer
Pipe 213 is sheathed on the periphery of said inner tube 212, and the upper end of outer tube 213 passes through first sliding block 215 and 217 phase of a locating part
Right, when sliding block 215 drives inner tube 212 and outer tube to move upward to certain position, upper end and the locating part 217 of outer tube 213 offset
It touches, outer tube 213 can not further up, and the first sliding block 215 drives 212 further uplink of inner tube then to cause outer tube 213 and inner tube
212 relative motions make the suction nozzle for being connected to 212 lower end of inner tube come off under the extruding of 213 lower end of outer tube, so as to fulfill automatic
Remove suction nozzle.Sample filling component 21 also has the elastic component 216 that the outer tube 213 is driven to reset, when 215 band of the first sliding block
After dynamic inner tube 212 and outer tube 213 move downward, locating part 217 is released from the limitation of the upper end of outer tube 213, and elastic component 216 is then
Driving outer tube 213 moves upwards reset so that and the suction nozzle bindiny mechanism 211 of 212 lower end of inner tube can be combined with suction nozzle again,
Again suction nozzle 113 is picked up.
As a kind of preferred embodiment, suction nozzle bindiny mechanism 211 includes being set in the cushion rubber of 212 periphery of said inner tube.It picks up
When taking suction nozzle, the first sliding block 15 driving inner tube 212 is downwardly into the oral area of suction nozzle, by the cushion rubber of 212 periphery of inner tube with inhaling
Suction nozzle is fixed on the lower end of the inner tube 212 by the interference fit of the inner wall in mouthpiece portion.
Sample filling component 21 is further provided with two limit switches 25,26, wherein, a limit switch is used to position
Sample fills the raising height of component 21, another limit switch is used to position the opposite position of the outer tube 213 and inner tube 212
It moves.Optoelectronic switch, magnetic switch or mechanical touch-pressure switch etc. may be used in limit switch.
Sample filling component 21 is supported in main support 60 by the first cantilever 22.
First driving mechanism 23 is used to that first sliding block 215 to be driven to move up and down.First driving mechanism 23 includes：Setting
The is set on the downside of the first cantilever 22 first substrate 231 opposite with the end of first cantilever 22, the first substrate 231
One support wheel 232；It is arranged on the guide rod 233 of the first sliding block 215 between 231 and first cantilever 22 of first substrate；Peace
The first motor 235 loaded on the first cantilever 22；And the first motor 235 of connection shaft and first support wheel 232 the
One transmission belt 234, first sliding block 215 are fixed on the first transmission belt 234.
Second driving mechanism 24 positions sample filling component 21 to finger for first cantilever 22 to be driven to move
Positioning is put.Second driving mechanism 24 includes：Second motor 242, the first driven wheel 242, the Yi Jishe for being arranged on combination bearing 70
Put the second transmission belt 243 between the shaft of the first driven wheel 241 and the second motor 242.
Sample filling mechanical arm 20 further includes a kind of control device, which is used to fill to corresponding by sample
After in photo making cup, continue that the air pressure in said inner tube 212 is controlled so that the sample is more between the suction nozzle and the photo making cup
Secondary repeated exchanged, which is realized, stirs sample, which can be an independent device, can also be filled with aforementioned control
It puts 50 and shares same hardware.
Fig. 2, Fig. 3, Fig. 5 and Fig. 6 are please referred to, the two-in-one mechanical arm 30 includes：Work head assembly 31, the second cantilever
32nd, 33 and the 4th driving mechanism 34 of third driving mechanism.Wherein, work head assembly 31 has waste liquid suction pipe 313, at least one dye
Color liquid filler pipe 312 and combination head 311, the combination head 311 are provided with several appearances parallel with the axis of combination head 311
Receive hole 310, waste liquid suction pipe 313 and at least one dyeing liquor filler pipe 312 are installed on several receiving holes 310 so as to group
It is integrated.
As a kind of preferred embodiment, a receiving hole in several receiving holes 310 is located at 311 end of combination head
At the center in face, remaining receiving hole be distributed in using the center of 311 end face of combination head as on the circumference in the center of circle, the waste liquid is inhaled
Pipe 313 is installed in the receiving hole at center.The quantity of dyeing liquor filler pipe 312 is identical with the type of dyeing liquor, end point
It is not connected by pump with corresponding dyeing liquid container, by controlling corresponding pump in use, aspirates and contaminate from corresponding dyeing liquor container
Color liquid is injected from the front end of dyeing liquor filler pipe in target photo making cup.And the end of waste liquid suction pipe 313 is then held by pump and waste liquid
Device connects, after centrifugation film-making, centrifugation dyeing, by controlling the pump to connect with waste liquid suction pipe 313, by the waste liquid in photo making cup
Discharge.Casing 314 further is connected in the rear end of combination head 311, storage protection is carried out to relevant liquid line.
The lower end of the combination head 311 is further designed as inversed taper platform structure, the waste liquid suction pipe 313 is from the combination
First 311 lower end protrudes, and the lower end (i.e. front end) of at least one dyeing liquor filler pipe 312 is in the combination head 311.
Work head assembly 31 is supported in main support 60 by the second cantilever 32.
Third driving mechanism 33 is used to that the work head assembly 31 to be driven to move up and down.Third driving mechanism 33 includes：If
It puts on 32 downside of the second cantilever second substrate 331 opposite with the end of second cantilever 32, the second substrate 331
Second support wheel 332 is set；The second sliding block between 331 and second cantilever 32 of second substrate is arranged on by guide rod
333, the work head assembly 31 is directly or indirectly connect with second sliding block 333；It is installed on the third horse of the second cantilever 32
Up to 334；And the shaft of third motor 334 and the third transmission belt 335 of second support wheel 332 are connected, described second slides
Block 333 is fixed on the third transmission belt 335.
Further limit switch (not shown) can be set in two-in-one mechanical arm 30 for positioning the work head group
The up and down motion terminal of part 31.Optoelectronic switch, magnetic switch or mechanical touch-pressure switch etc. may be used in limit switch.
4th driving mechanism 34 positions the work head assembly 31 to specified for second cantilever 32 to be driven to move
Position including the 4th motor 341, is arranged on the second driven wheel 343 of combination bearing 70 and connects the second driven wheel 343
With the 4th transmission belt 342 of the shaft of the 4th motor 341.
Fig. 7 is please referred to, as a kind of preferred embodiment, the sample filling mechanical arm 20 and the two-in-one mechanical arm 30
Rack is installed on by combining installing mechanism, the combination installing mechanism includes being arranged on the main support 60 above workbench, with
And the combination bearing 70 on the main support 60 is arranged on, the combination bearing 70 includes tubular base 72, is sheathed on the pipe
Tubular outer shaft 71 outside shape pedestal 72 and the inner shaft 73 being inserted in the tubular base 72, the tubular base 72 are installed in institute
Main support 60 is stated, the sample filling mechanical arm 20 and the two-in-one mechanical arm 30 pass through the first cantilever 22 and the second cantilever 32
It is installed in the inner shaft 73 and the outer shaft 71 respectively.It designs whereby, complete machine structure can be made compacter, neatly.
Fig. 8 to Figure 11 is please referred to, each photo making cup 112 includes third substrate 1121, is arranged on the third substrate
The collector tube 1124 of 1121 sides and the glass slide for being inserted in the third substrate 1121 and being connected with the collector tube 1124
1125, several photo making cup holding tanks 1111 of setting at the outer of first turntable 111, several photo making cups 112 correspond to peace
Loaded on being pivotally connected in several photo making cup holding tanks 1111 with the side wall of place holding tank 1111, by the glass slide of photo making cup 112
1125 are transversely supported on first turntable 1111.Compared in existing production facility by the design of glass slide vertical supporting and
Speech, the sample of the glass slide of above-mentioned cross-brace after film-making on glass slide are more uniform.More specifically, in collector tube 1124
There is outwardly projecting prominent button 1123 in lower end, is rotated behind the installation position that 1124 lower end of collector tube is inserted on third substrate 1121 described in making
Collector tube 1124 is connected on third substrate 1121 by prominent 1123 button bit cooperation corresponding on substrate of button.In third substrate 1121
Both sides be provided with prominent axis 1122, be correspondingly arranged on recess portion 1112 in the cell wall of holding tank 1111, match with the prominent axis 1122
Photo making cup 112 is supported in holding tank 1111 by conjunction.113 be suction nozzle loading hole in Figure 10.
Further, the first turntable 111 under static state, has 1 to 8 between the glass slide and horizontal plane of photo making cup 112
The angle of degree.By the design, not only sample evenly can be obtained, and in glass slide convenient for drawing the mark in photo making cup
This waste liquid generated after film-making and dyeing.
Fig. 2 and Figure 12 are please referred to, several specimen cup holding tanks are set at the outer of the second turntable 121, each specimen cup 122 is right
It should be arranged in several specimen cup holding tanks.
In the present invention, sample first carries out centrifugal concentrating in sample chamber 12, then transfers in film-making chamber 11 and is made
Piece and dyeing.
In order to realize the concentration of the high speed centrifugation of sample and high accuracy positioning, it is special to be devised for the turntable in sample chamber
Driving mechanism.Figure 13 is please referred to, the driving mechanism 123 of the second turntable 121 includes two motors 1231,1234, one of horse
Up to 1234 for driving 121 high-speed rotation of the second turntable, the high speed centrifugation concentration of sample is realized, another motor 1231 is used to drive
Dynamic second turntable 121, which slowly runs, positions target specimen cup to designated position, then fills mechanical arm by sample by sample
It is transferred in the photo making cup in film-making chamber.
In an exemplary embodiment, the turntable 121 in the sample chamber shaft setting unilateral bearing 1233, it is described another
Motor 1231 drives the unilateral bearing 1233 to drive the second turntable 121 by belt 1232.It, can using above-mentioned design
It avoids high speed centrifugation that another described motor 1231 is driven to rotate in handling, harmful effect is generated to equipment.
For film-making and dyeing course, centrifugation requirement, therefore first turn in film-making chamber are can reach using stepper motor
The driving mechanism 114 of disk 111 employs single motor drive mechanism.
Figure 14 is please referred to, the temperature control mechanism 40 includes heat source, which has a cool-bag 42 and be set to the guarantor
Heater element 41 in warm container 42.Further include hot blast pipe 45 and backwind tube 44, they be arranged on the heat source and film-making chamber it
Between.Further include power source 43, for drive the thermal energy that the heat source generates through the hot blast pipe 45 enter the film-making chamber and
The air return of the film-making intracavitary is driven to the cool-bag 42.Temperature inductor (not shown) is further included, is used for
Detect the temperature of the film-making intracavitary.Controller (not shown) is further included, for acquiring the output of the temperature inductor
It is worth and then controls the temperature of the film-making intracavitary.
As a kind of embodiment, the power source 43 is wind turbine, and the wind turbine is set to the cool-bag 42 of heat source
In, the air intake of the wind turbine is opposite with the outlet of the backwind tube 44, outlet air end is opposite with the entrance of the hot blast pipe 45, institute
Heater element 41 is stated to be arranged between the entrance of the wind turbine and the hot blast pipe 45.
The heater element 41 uses semiconductor heating element, small, easy for installation.
The hot blast pipe 45 and backwind tube 44 extend to the film-making chamber by the shaft of the first turntable of the film-making intracavitary
Interior, the rotation of the first turntable does not interfere with temperature control mechanism normal work.Further, temperature control mechanism 40 includes a plurality of hot blast pipe
45, the outlet of a plurality of hot blast pipe 45 is arranged in fan-shaped, and the temperature in film-making chamber everywhere can be made more consistent, tie detection
Fruit is more accurate.
The full-automatic liquid-based cell sample manufacturing colouring method of some embodiments is dyed using above-mentioned full-automatic liquid-based cell sample manufacturing
All-in-one machine the described method comprises the following steps：
121 high-speed rotation of the second turntable is controlled to concentrate specimen centrifuge；
First turntable, 111 and second turntable 121 is located in designated position；
Sample shifts：Sample filling mechanical arm 20 picks up new suction nozzle 113, and sample is drawn from specimen cup and is transferred to working position
Photo making cup 112 in, then remove suction nozzle 113；
Next specimen cup and photo making cup are turned into working position, repeat above-mentioned sample transfer step；It is complete to repeat the step
It is shifted into sample；
The first turntable 111 is controlled to rotate, centrifuges film-making；And
Coloring agent fills each photo making cup by two-in-one mechanical arm 30, centrifugation dyeing passes through two-in-one mechanical arm 30
Discharge the waste liquid in photo making cup.
The present invention is described in detail above by specific embodiment, these detailed description are only limited to help
Those skilled in the art understand that present disclosure, can not be interpreted as limiting the scope of the invention.Art technology
Various retouchings that personnel carry out said program under present inventive concept, equivalent transformation etc. should be included in the protection model of the present invention
In enclosing.
Claims (11)
1. a kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, which is characterized in that including：
Rack (10), including the film-making chamber (11) with the first turntable (111), with the film-making chamber side by side with the second turntable
(121) sample chamber (12) and the driving mechanism of first turntable and the second turntable (114,123)；
Several photo making cups (112) are arranged on first turntable (111)；
Several specimen cups (122) are arranged on second turntable (121)；
Several suction nozzles (113)；
For picking up suction nozzle and sample being transferred to the sample filling mechanical arm (20) of corresponding photo making cup from specimen cup；
For filling dyeing liquor into photo making cup and discharging the two-in-one mechanical arm (30) of waste liquid；
For controlling the temperature control mechanism (40) of the film-making chamber temperature；And
Control device (50), is used for：Control first turntable, the second turntable, sample filling mechanical arm and two-in-one mechanical arm
By program work, the sample in specimen cup is subjected to centrifugal concentrating, transfers to corresponding photo making cup, be then centrifuged for film-making and
Dyeing.
2. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, which is characterized in that the sample filling
Mechanical arm (20) includes：
Sample filling component (21), the component have inner tube (212) and outer tube (213), and the lower end setting suction nozzle of said inner tube connects
Connection mechanism (211), upper end are fixedly connected with the first sliding block (215), and inner tube is also associated with tracheae for being inhaled by pressure control suction nozzle
Enter or discharge sample, the outer tube sleeve is set on the periphery of said inner tube, and the upper end of outer tube passes through first sliding block and a limiting
Part (217) is opposite to be used to that the outer tube and said inner tube relative motion to be controlled to make after said inner tube moves upward to certain position
The suction nozzle for being connected to said inner tube lower end comes off, which also has the elastic component (216) that the outer tube is driven to reset；
First cantilever (22), for the sample to be filled modular support in main support (60)；
First driving mechanism (23), for first sliding block (215) to be driven to move up and down；And
Second driving mechanism (24), for first cantilever motion to be driven to position sample filling component to specific bit
It puts.
3. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, which is characterized in that the two-in-one machine
Tool arm (30) includes：
Work head assembly (31), the component have waste liquid suction pipe (313), at least one dyeing liquor filler pipe (312) and combination
Head (311), the combination head are provided with several receiving holes (310) parallel with the axis of the combination head for installing the waste liquid
Suction pipe and at least one dyeing liquor filler pipe；
Second cantilever (32), for the work head assembly to be supported in main support (60)；
Third driving mechanism (33), for the work head assembly to be driven to move up and down；And
4th driving mechanism (34), for second cantilever motion to be driven to position the work head assembly to designated position.
4. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 3, which is characterized in that several receivings
A receiving hole in hole (310) is located at the center of the combination head (311) end face, remaining receiving hole is distributed in described group
The center of syncephalon (311) end face is on the circumference in the center of circle, the waste liquid suction pipe (313) is installed in the receiving hole at center.
5. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, it is characterised in that：The sample filling
Mechanical arm and the two-in-one mechanical arm are installed on rack by combining installing mechanism, and the combination installing mechanism includes being arranged on
Main support (60) above workbench and the combination bearing (70) being arranged on the main support, the combination bearing include pipe
Shape pedestal (72), the tubular outer shaft (71) being sheathed on outside the tubular base and the inner shaft being inserted in the tubular base
(73), the tubular base (72) is installed in the main support (60), the sample filling mechanical arm and the two-in-one machinery
Arm is corresponded to is installed in the inner shaft (73) and the outer shaft (71) by the first cantilever (22) and the second cantilever (32).
6. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, it is characterised in that：Each film-making
Cup (112) including third substrate (1121), be arranged on the collector tube (1124) of the third substrate side and be inserted in the third
The glass slide (1125) connected in substrate and with the collector tube, several film-makings of setting at the outer of first turntable (111)
Cup holding tank (1111), several photo making cup correspondences are installed on the side in several photo making cup holding tanks with place holding tank
Wall is pivotally connected, and the glass slide of photo making cup is transversely supported on first turntable.
7. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 6, it is characterised in that：First turntable
(111) under static state, the glass slide (1125) of photo making cup has the angle of 1 to 8 degree between horizontal plane.
8. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, it is characterised in that：Second turntable
(121) driving mechanism (123) includes two motors (1231,1234), and one of motor is used to drive second turntable
High-speed rotation, another motor position target specimen cup to designated position for second turntable to be driven to slowly run.
9. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 8, it is characterised in that：Second turntable
(121) shaft setting unilateral bearing (1233), another described motor drive second turntable by the unilateral bearing
(121)。
10. full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, which is characterized in that the temperature controlling machine
Structure (40) includes：
Heat source has a cool-bag (42) and the heater element (41) being set in the cool-bag；
The hot blast pipe (45) and backwind tube (44) being arranged between the heat source and the film-making chamber；
Power source (43), for the thermal energy that the heat source generates to be driven to enter the film-making chamber and driving through the hot blast pipe
The air return of the film-making intracavitary is to the cool-bag (42)；
Temperature inductor, for detecting the temperature of the film-making intracavitary；And
Controller, for acquiring the temperature of the output valve of the temperature inductor and then the control film-making intracavitary.
11. a kind of full-automatic liquid-based cell sample manufacturing colouring method, which is characterized in that using any one in claims 1 to 10
The full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, the described method comprises the following steps：
The second turntable high-speed rotation is controlled to concentrate specimen centrifuge；
First turntable and the second turntable are located in designated position；
Sample shifts：Sample filling mechanical arm picks up new suction nozzle, draws sample and is transferred in the photo making cup of working position, then removes
Suction nozzle；
Next specimen cup and photo making cup are turned into working position, repeat above-mentioned sample transfer step；It repeats the step and completes mark
This transfer；
Centrifuge film-making；And
Coloring agent fills each photo making cup by two-in-one mechanical arm, centrifugation dyeing discharges film-making by two-in-one mechanical arm
Waste liquid in cup.
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|---|---|---|---|
| CN201810237229.5A CN108168986A (en) | 2018-03-21 | 2018-03-21 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
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|---|---|---|---|
| CN201810237229.5A CN108168986A (en) | 2018-03-21 | 2018-03-21 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
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| CN108168986A true CN108168986A (en) | 2018-06-15 |
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| CN109520805A (en) * | 2018-11-27 | 2019-03-26 | 武汉医尔特科技有限公司 | A kind of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine |
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| CN113218730A (en) * | 2021-04-25 | 2021-08-06 | 南京江河华晟医学检验实验室有限公司 | Quality control and guarantee method for liquid-based membrane type cytology full-automatic dyeing |
| CN113188871A (en) * | 2021-05-26 | 2021-07-30 | 北京诚智光辉科技有限公司 | Cell film-making dyeing all-in-one with liquid structure falls |
| CN113994956A (en) * | 2021-11-18 | 2022-02-01 | 闽南师范大学 | Plant specimen green-keeping processing device and method for keeping green by using same |
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