CN109507438B - Linear incubation groove and full-automatic biochemical analyzer thereof - Google Patents
Linear incubation groove and full-automatic biochemical analyzer thereof Download PDFInfo
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- CN109507438B CN109507438B CN201811326054.1A CN201811326054A CN109507438B CN 109507438 B CN109507438 B CN 109507438B CN 201811326054 A CN201811326054 A CN 201811326054A CN 109507438 B CN109507438 B CN 109507438B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
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Abstract
The invention discloses a linear incubation groove and a full-automatic biochemical analyzer thereof, comprising an incubation groove body, a reaction cup holder arranged in the incubation groove body and a cup holder driving assembly for driving the reaction cup holder to translate, wherein the incubation groove body is provided with an injection hole; the two sides of the incubation groove body are respectively provided with a light hole, the outer side of the light hole is provided with an optical detection unit for detecting samples in the reaction container, the purposes of removing a traditional incubation disc type mechanism and a mixing mechanism for mixing liquid in the reaction cup are achieved, the size of the instrument is reduced, the structural complexity of the instrument is reduced, and the cost is reduced while the overall reliability of the instrument is improved.
Description
Technical Field
The invention relates to a medical instrument, in particular to a linear incubation groove and a full-automatic biochemical analyzer thereof.
Background
With the continuous progress of social economy and science and technology, the technology of the full-automatic biochemical analyzer is unprecedentedly developed. The full-automatic biochemical analyzer is not only distributed in various medium-large medical units, but also continuously popularized to villages, towns and community hospitals at present.
In the market, most of rural and urban hospitals and community hospitals mostly use semi-automatic biochemical analyzers due to the fact that the daily test sample amount is small, although the price of the analyzer is low, only one test position is usually needed, samples and reagents need to be added into a test container manually, and the samples and the reagents need to be shaken up manually. Therefore, the time points of adding the sample and the reagent into the reaction cup at each time are mostly inconsistent, the effect deviation of mixing at each time is very large, the accuracy and the consistency of the test are seriously influenced, and the possibility of misjudgment of the result is very high. This causes great trouble to the doctor clinical judgement state of an illness, seriously influences the sound life safety of the patient even.
Under the environment, aiming at the particularity of villages, towns and community hospitals, a full-automatic biochemical analyzer with low cost, high reliability and small volume is newly developed.
Therefore, the prior art still needs to be improved and developed.
Disclosure of Invention
The invention aims to provide a linear incubation groove and a full-automatic biochemical analyzer thereof, which achieve the purposes of removing a traditional incubation disc disk type mechanism and a blending mechanism for blending liquid in a reaction cup, reduce the size of the instrument, reduce the structural complexity of the instrument, improve the overall reliability of the instrument and reduce the cost.
The technical purpose of the invention is realized by the following technical scheme:
a linear incubation groove comprises an incubation groove body, a reaction cup holder arranged in the incubation groove body and a cup holder driving assembly used for driving the reaction cup holder to translate, wherein the incubation groove body is provided with an injection hole; the two sides of the incubation groove body are respectively provided with a light hole, and the outer side of the light hole is provided with an optical detection unit for detecting samples in the reaction container.
The linear incubation groove, wherein, the reaction glass stand offers the reaction hole that is used for placing reaction vessel along length direction, the both sides of reaction glass stand with the position punishment that the reaction hole corresponds do not is provided with logical unthreaded hole, the height and the width that lead to the unthreaded hole with correspond one side the light trap adaptation, both sides the parallel and concentric setting of light trap.
The linear incubation trough, wherein the cup holder driving component comprises a cup holder fixing seat for supporting the reaction cup holder, a fixing seat screw rod for driving the cup holder fixing seat, and a guide rod which is arranged in parallel with the screw rod and plays a role in guiding; the both ends of glass stand fixing base are provided with the elasticity pin respectively, the both ends of reaction glass stand bottom be provided with respectively with the location fixed orifices of elasticity pin adaptation, be provided with on the glass stand fixing base and supply reaction glass stand male guide way.
The linear incubation groove, wherein, the fixing base lead screw set up in the incubation groove body, the fixing base lead screw sets up along the length direction of incubation groove body, be provided with on the glass stand fixing base with the screw nut of fixing base lead screw adaptation and with the linear bearing of guide bar adaptation.
The linear incubation groove is characterized in that two sides of the incubation groove body are respectively provided with a rotating shaft fixing piece, a cylindrical pin is arranged on the rotating shaft fixing piece, the front end of the incubation groove body is provided with a heat preservation cover, the heat preservation cover is rotatably connected to the cylindrical pin, and a blocking piece used for limiting the rotation angle of the heat preservation cover is arranged on the rotating shaft fixing piece; the heat preservation is covered and has been seted up the ring channel, the intussuseption of ring channel is provided with the sealing strip, be provided with the magnet of looks adaptation on heat preservation lid and the hatching cell body respectively.
A fully automated biochemical analyzer according to any of the above claims, comprising a sample reagent tray for carrying sample containers and reagent containers, and a probe mechanism; the probe mechanism is used for rotating to a station of a required sample container or a required reagent container in the sample reagent tray, sucking a sample or a reagent and injecting the sample or the reagent into a corresponding reaction container in the incubation groove body, and sucking, spitting and uniformly mixing liquid in the reaction container.
The full-automatic biochemical analyzer comprises an optical detection unit, a support body, a lamp holder and a selective optical filter, wherein the optical detection unit is arranged at the bottom of an incubation groove body, the optical detection unit comprises the support body arranged at the bottom of the incubation groove body, the lamp holder arranged at one end of the support body and the selective optical filter arranged at the other end of the support body, a photoelectric cell box is arranged at the upper end of the selective optical filter, and cooling fins and cooling fans connected to the cooling fins are arranged below the lamp holder.
The full-automatic biochemical analyzer is characterized in that the probe mechanism comprises a rack arranged on one side of the incubation groove body, a swing arm is arranged above the rack, a spline shaft is arranged between the rack and the swing arm and arranged at one end of the swing arm, a probe is arranged at the other end of the swing arm, and a probe driving assembly for driving the spline shaft to move is arranged in the rack; and a cleaning pool for cleaning the inner wall and the outer wall of the probe is arranged on one side of the probe mechanism.
The full-automatic biochemical analyzer is characterized in that the probe driving assembly comprises a lifting motor arranged in the frame, a lifting guide rod matched with the spline shaft, and a lifting driving belt wheel driven by the lifting motor and driving the spline shaft to move along the lifting guide rod through a synchronous belt, and the lifting motor drives the probe to descend to suck a sample or a reagent.
The full-automatic biochemical analyzer, wherein, probe mechanism is still including setting up the rotational positioning opto-coupler in the frame upper end, the rotational positioning opto-coupler just is used for judging with waiting to inhale the position one-to-one who tells sample or reagent the integral key shaft rotational position.
In conclusion, by applying the invention, the purposes of removing the traditional disc type incubation disc mechanism and the blending mechanism for blending the liquid in the reaction cup are achieved, the size of the instrument is reduced, the structural complexity of the instrument is reduced, and the cost is reduced while the overall reliability of the instrument is improved.
Drawings
Fig. 1 is a schematic view of the overall structure of the fully automatic biochemical analyzer in this embodiment.
FIG. 2 is a schematic view showing the external structure of the linear incubation groove of this embodiment.
FIG. 3 is a schematic view showing the internal structure of the linear incubation groove of this embodiment.
FIG. 4 is a schematic view of the connection structure of the incubation groove and the heat-preservation cover in this embodiment.
Fig. 5 is a schematic structural view of the probe mechanism in this embodiment.
Fig. 6 is a schematic structural diagram of the optical detection unit in this embodiment.
In the figure: 1. a linear incubation groove; 101. incubating the tank body; 102. a reaction cup holder; 103. a cup holder fixing seat; 104. a fixed seat screw; 105. a lead screw nut; 106. a lead screw driven pulley; 107. a lead screw driving belt wheel; 108. a drive motor; 109. a guide bar; 110. a linear bearing; 111. a linear positioning optical coupler; 112. code disc; 113. a heat preservation cover; 114. a sealing strip; 115. the rotating shaft fixing sheet; 116. filling holes; 117. a reaction well; 118. a light through hole; 119. a light-transmitting hole; 2. an optical detection unit; 201. a lamp socket; 202. a photo cell box; 203. a selective optical filter; 204. a heat sink; 205. a heat radiation fan; 3. a probe mechanism; 301. a probe; 302. a spline shaft; 303. a driving rotating belt wheel; 304. a rotating electric machine; 305. rotating and positioning the optocoupler; 306. a lifting motor; 307. a lifting driving belt wheel; 308. a lifting guide rod; 4. and (5) cleaning the pool.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Example (b): the embodiment of the invention provides a linear incubation tank, as shown in fig. 1 to 3, which comprises an incubation tank body 101, a reaction cup holder 102 arranged in the incubation tank body 101, and a cup holder driving assembly for driving the reaction cup holder 102 to move, wherein a filling hole 116 is formed in the incubation tank body 101, and the filling hole 116 is arranged at a point where a rotation circumference of a probe 301 intersects or is intersected with a linear motion track of a reaction container. Light holes 119 are formed in two sides of the incubation groove body 101 respectively, the light holes 119 in the two sides are arranged in parallel and concentrically, and the outer sides of the two light holes 119 correspond to the optical detection unit 2 and the perspective mirror assembly respectively.
The reaction cup holder 102 is provided with a reaction hole 117 for placing a reaction container along a linear direction. Light holes 118 are arranged at positions corresponding to the reaction holes 117 on two sides of the reaction cup holder 102, and the height and width of each light hole 118 are matched with the light holes 119 on the corresponding side, so that the absorbance of liquid in the reaction container is measured when the reaction container passes through the optical detection unit. Specifically, the reaction vessel is a reaction cup.
The cup holder driving assembly includes a cup holder fixing base 103 for holding the reaction cup holder 102, a fixing base screw 104 for driving the cup holder fixing base 103, and a guide rod 109 provided parallel to the screw and having a guiding function.
The front end of incubating the cell body 101 is provided with heat preservation lid 113, the outer wall of incubating the cell body 101 is attached and is provided with the heating tape, the periphery of heating tape is attached to have the heat preservation cotton.
Specifically, it is the aluminum alloy material to incubate cell body 101, has good heat conductivity, the outer wall of incubating cell body 101 is attached to have the heating tape, the periphery of heating tape is attached to have the heat preservation cotton.
Elastic pins are respectively arranged at two ends of the cup holder fixing seat 103, positioning fixing holes matched with the elastic pins are respectively arranged at two ends of the bottom of the reaction cup holder 102, and a guide groove for inserting the reaction cup holder 102 is formed in the cup holder fixing seat 103.
Specifically, the reaction cup holder 102 is fixed to the cup holder fixing base 103, elastic pins are respectively disposed at two ends of the cup holder fixing base 103, positioning fixing holes adapted to the elastic pins are respectively disposed at two ends of the bottom of the reaction cup holder 102, and the reaction cup holder 102 is inserted into the cup holder fixing base 103 through a guide groove. When the reaction cup holder 102 is inserted into the cup holder fixing seat 103 through the guide groove, the elastic pin sinks into the interior of the cup holder fixing seat 103, after the reaction cup holder 102 is put in place, the elastic pin pops out to fix the reaction cup holder 102 and the cup holder fixing seat 103, and the heat preservation cover 113 is closed at the moment.
A fixed seat screw 104 is arranged in the incubation groove body 101, the fixed seat screw 104 is arranged along the length direction of the incubation groove body 101, and a screw nut 105 matched with the fixed seat screw 104 and a linear bearing 110 matched with the guide rod 109 are arranged on the cup holder fixed seat 103; the bottom of the cup holder fixing seat 103 is provided with a coded disc 112 and a linear positioning optical coupler 111 for positioning a reaction container.
As shown in fig. 4, two sides of the incubation groove body 101 are respectively provided with a rotating shaft fixing piece 115, a cylindrical pin is arranged on the rotating shaft fixing piece 115, the heat preservation cover 113 is rotatably connected to the cylindrical pin, and a blocking piece for limiting the rotation angle of the heat preservation cover 113 is arranged on the rotating shaft fixing piece 115; an annular groove is formed in the heat-insulating cover 113, and a sealing strip 114 is filled in the annular groove; the heat preservation cover 113 and the incubation groove body 101 are respectively provided with magnets which are matched with each other.
Specifically, the cup holder fixing base 103 is provided with a screw nut 105 and a linear bearing 110, and the screw nut 105 moves on the fixing base screw 104 to drive the linear bearing 110 to move synchronously on the guide rod 109. One end of the fixed seat screw 104 is provided with a screw driven pulley 106, the screw driven pulley 106 is connected to a screw driving pulley 107 through a synchronous belt, and the screw driving pulley 107 is fixed on an output shaft of the driving motor 108. The bottom of the cup holder fixing seat 103 is provided with a coded disc 112 and a linear positioning optical coupler 111 for positioning the position of the reaction container.
An annular groove is formed in the heat-insulating cover 113, a sealing strip 114 is filled in the annular groove, a magnet is arranged at the upper end of the heat-insulating cover 113, and a magnet is also arranged on the incubation groove body 101. When the heat preservation cover 113 is closed, the magnet is attracted, and the sealing strip 114 is compressed, so that the incubation groove body 101 is kept sealed, and the constant temperature environment in the incubation groove body 101 is ensured.
Two sides of the incubation groove body 101 are respectively provided with a rotating shaft fixing piece 115, and the heat preservation cover 113 rotates around a cylindrical pin on the rotating shaft fixing piece 115. When the heat preservation cover 113 is opened and turned to the horizontal position, the blocking piece on the rotating shaft fixing piece 115 prevents the heat preservation cover 113 from continuously rotating so that the heat preservation cover 113 can be opened and closed to the horizontal position to the maximum extent, and therefore other elements on the instrument cannot be collided.
The present invention also provides a full-automatic biochemical analyzer as described above, as shown in fig. 1, the full-automatic biochemical analyzer includes:
the linear incubation tank 1 is used for bearing a reaction container, driving the reaction container to do linear motion back and forth and providing an incubation environment for the reaction container;
a sample reagent tray for carrying sample containers and reagent containers;
the optical detection unit 2 is used for carrying out photoelectric data measurement on the liquid in the reaction container;
specifically, the optical detection unit 2 is used to measure the absorbance of the liquid in the reaction vessel;
the probe mechanism 3 is used for rotating to the position of a required sample container or reagent container in the sample reagent tray, sucking a quantitative sample or reagent, filling the quantitative sample or reagent into a corresponding reaction container in the incubation groove, and sucking, spitting and uniformly mixing liquid in the reaction container;
the cleaning pool 4 is used for cleaning the inner wall and the outer wall of the probe 301;
the track of the central linear motion of the reaction container on the linear incubation groove 1 is intersected or tangent with the track of the swinging arc of the probe 301; the reaction vessel at the point of intersection or tangency may serve as the fill location for probe 301.
As shown in fig. 5, the probe mechanism 3 includes a frame disposed on one side of the incubation groove 101, a swing arm is disposed above the frame, a spline shaft 302 is disposed between the frame and the swing arm, the spline shaft 302 is disposed at one end of the swing arm, a probe 301 is disposed at the other end of the swing arm, and a probe driving assembly for driving the spline shaft 302 to move is disposed in the frame; and a cleaning pool 4 for cleaning the inner wall and the outer wall of the probe 301 is arranged on one side of the probe mechanism 3.
The probe mechanism 3 is arranged at one side of the linear incubation groove 1, and the rotation circumference of the probe 301 is tangent or intersected with the linear motion track of the reaction vessel.
The probe driving assembly comprises a lifting motor 306 arranged in the frame, a lifting guide rod 308 matched with the spline shaft 302, and a lifting driving pulley 307 driven by the lifting motor 306 and driving the spline shaft 302 to move along the lifting guide rod 308 through a synchronous belt, wherein the lifting motor 306 operates to drive the probe 301 to descend to suck a sample or a reagent.
The probe mechanism 3 further comprises a rotary positioning optical coupler 305 arranged at the upper end of the rack, and the rotary positioning optical coupler 305 corresponds to the position of a sample or a reagent to be sucked and spitted one by one and is used for judging the rotating position of the spline shaft 302.
Specifically, probe 301 passes through the swing arm to be fixed on the top of integral key shaft 302, rotating electrical machines 304 drive initiative rotatory band pulley 303 and passes through the hold-in range and drive integral key shaft 302 rotatory, and rotational positioning opto-coupler 305 judges integral key shaft 302 rotational position, and rotational positioning opto-coupler 305 and the position one-to-one that needs absorb sample or reagent to probe 301 reachs the container top that needs absorb sample or reagent through the rotation.
The working principle of the probe mechanism 3 in the embodiment of the invention is as follows:
the lifting motor drives the lifting driving belt wheel to drive the spline shaft to move along the lifting guide rod through the synchronous belt, and when the swinging arm with the probe rotates to the position above a container needing to absorb samples or reagents, the lifting motor operates to drive the probe to descend to absorb the samples or the reagents. After the probe sucks a sample or a reagent, the lifting motor operates to drive the probe to ascend to a position separated from the opening of the sample tube or the reagent container, at the moment, the rotating motor operates to drive the probe to swing to a filling hole formed in the top of the incubation groove body, the lifting motor operates to drive the probe to be downwards pricked into the reaction container, and the sample or the reagent is filled into the reaction container. At this time, the lift motor drives the probe to separate from the liquid surface, the probe sucks a predetermined amount of air, and the probe is inserted below the liquid surface again, and the sucking, discharging and mixing actions are repeatedly performed, preferably twice. After the uniform mixing is finished, the probe is separated from the tank body under the driving of the lifting motor, and is rotated to a cleaning tank station under the driving of the rotating motor, so that the inner wall and the outer wall are cleaned, and an action period of the probe is finished.
As shown in fig. 6, the optical detection unit 2 is disposed at the bottom of the incubation tank 101, the optical detection unit 2 includes a frame body disposed at the bottom of the incubation tank 101, a lamp holder 201 disposed at one end of the frame body, and a selective filter 203 disposed at the other end of the frame body, a photovoltaic cell box 202 is disposed at the upper end of the selective filter 203, and a heat sink 204 and a heat dissipation fan 205 connected to the heat sink 204 are disposed below the lamp holder 201.
Specifically, the optical detection unit 2 is used for performing optical data measurement on the reaction vessel, and provides, for example, 8-way selective filters 203 arranged in parallel and side by side, and performing detection of 8 wavelengths simultaneously. The optical detection unit 2 performs photoelectric data measurement of a specific wavelength of each reaction vessel while the reaction vessel is linearly moved and passes through the optical measurement channel.
The working process of the full-automatic biochemical analyzer in the embodiment of the invention is as follows:
the cup holder driving motor drives the reaction cup holder to move to the filling position, and at the moment, a reaction container of a sample or a reagent to be filled is positioned right below the filling hole in the incubation groove body.
The probe swings to the position of a reaction container to absorb the sample or the reagent, then returns to the position right below the filling hole in the incubation groove body, the lifting motor runs to drive the probe to be inserted into the reaction container, and the sample or the reagent is filled into the reaction container.
At this time, the probe is separated from the liquid surface by the driving of the elevating motor, sucks a predetermined amount of air, and then stabs down below the liquid surface again, and repeats the sucking-discharging-mixing operation, preferably twice.
After the mixing, the probe breaks away from under elevator motor's drive and incubates the cell body, under rotary motor's drive, rotates to washing station, washs the pond position promptly, carries out the washing of inside and outside wall.
Meanwhile, the cup holder driving motor drives the reaction cup holder to move and pass through the optical measurement channel, the optical detection unit finishes the optical data measurement of the specific wavelength of each reaction container, then the cup holder driving motor drives the reaction cup holder to move to the next reaction container filling station, and the actions of filling a sample or a reagent and uniformly mixing are continued until the reaction is finished.
The biochemical analyzer provided by the embodiment of the invention takes single reagent reaction as an example, and in each reaction working period, the probe needs to complete the filling, mixing and cleaning of a sample and the filling, mixing and cleaning of a reagent. Meanwhile, the linear incubation groove moves twice and carries out photoelectric data measurement.
The existing biochemical analyzer at least comprises a probe, a reaction cup and a stirring paddle, and after filling and mixing are completed each time, the reaction cup, the probe and the stirring paddle need to be cleaned to prevent cross contamination, and the water consumption is very high, so that the existing biochemical analyzer is a trouble for an area partially lack of water. Meanwhile, the semi-automatic biochemical analyzer adopts a mode of manually adding samples and reagents, so that large human deviation factors exist, the amount of the samples and the amount of the reagents added each time are not always consistent, the precision of measured values is seriously reduced, the accuracy of test is influenced, great trouble is caused for a doctor to clinically judge the state of an illness, and even the life safety of a patient is influenced in the serious case.
The dish of hatching is the carousel formula structure in traditional biochemical analysis appearance, and the reaction cup is all to distribute on hatching a set circumference, and it contains the rotation drive to hatch to coil, drives the reaction cup and does regular rotation, and the regular rotation of cooperation probe and sample reagent dish accomplishes the filling of sample and reagent to the mixing of liquid in the reaction cup is accomplished through the rotation of mixing mechanism.
In the embodiment of the invention, the linear incubation groove is adopted to replace the rotary disc type incubation disc of the traditional biochemical analyzer, the middle part of the traditional incubation disc except the rotating mechanism cannot be utilized, and the size of the constant temperature groove in the traditional incubation disc is larger than that of a fixed incubation groove. The invention simplifies the whole structure and reduces the cost while more compactly utilizing the space.
The invention provides a probe sucking, spitting and mixing mode without a mixing mechanism, and the probe immediately performs sucking, spitting and mixing actions on the liquid in the current reaction container after the sample is filled into the probe each time. After the uniform mixing is finished, the stirring paddle swings to the cleaning pool for cleaning, so that water for cleaning the stirring paddle in each working period of the traditional analyzer is saved, and the cost required by a uniform mixing mechanism is saved.
Compared with the prior art, the conventional stirring paddle is generally a flat paddle stirring paddle, when liquid in the reaction vessel is stirred, the liquid in the reaction vessel forms a laminar flow, the liquid in the reaction cup is microscopically divided into a plurality of sheet layers, the liquid in each layer rotates around the center of the stirring paddle, the liquid in the upper layer is difficult to diffuse into the liquid in the lower layer under the condition that the rotating speed of the stirring paddle is not high, and if an ideal uniform mixing effect is achieved, higher requirements on the rotating speed of the stirring paddle need to be provided.
On the contrary, the probe is inhaled and is told the mode of mixing, and when liquid was passing through the probe internal diameter of very little diameter in the reaction cup, the probe internal diameter generally was no longer than 0.5mm, and inside liquid strived for the extrusion to get into the probe, when liquid process probe tip aperture, turbulent flow took place for liquid, made its preliminary mixing in the probe. When liquid is spit out from the probe and enters the reaction vessel, the liquid is irregularly moved when entering the reaction vessel due to the impact force, and is further uniformly mixed, so that the purpose of fully and uniformly mixing is achieved.
In summary, in order to increase the reliability of the instrument, reduce the cost and reduce the size of the instrument, the invention provides: the square groove type incubation disc is not required to rotate and only needs to move back and forth. The swing arc of the probe is intersected or tangent with the linear motion track of the center of the reaction cup in the incubation groove. The reaction cup where the intersecting or tangent point is located can be used as a probe filling position; and a mixing mechanism is not needed, and after the probe fills the sample each time, the liquid in the current reaction cup is immediately sucked, spitted and mixed. After the uniform mixing is finished, the stirring paddle is swung to the cleaning pool for cleaning, so that water for cleaning the stirring paddle in each working period of the traditional analyzer is saved, the cost required by a uniform mixing mechanism is saved, the size of a rotating disc type incubation disc of the traditional biochemical analyzer is greatly reduced by the linear incubation groove, and the manufacturing cost is reduced.
By applying the invention, the traditional disc type mechanism of the incubation disc and the mixing mechanism for mixing the liquid in the reaction cup are eliminated, and the water consumption of the mixing paddle of the traditional biochemical analyzer is saved. The analyzer has the advantages of greatly reducing the size of the analyzer, reducing the structural complexity of the analyzer, improving the overall reliability, reducing the cost and saving water.
It is to be understood that the invention is not limited to the examples described above, but that modifications and variations may be effected thereto by those of ordinary skill in the art in light of the foregoing description, and that all such modifications and variations are intended to be within the scope of the invention as defined by the appended claims.
Claims (3)
1. A full-automatic biochemical analyzer is characterized in that: the linear incubation trough comprises an incubation trough body, a reaction cup holder arranged in the incubation trough body and a cup holder driving assembly used for driving the reaction cup holder to translate, wherein the incubation trough body is provided with a filling hole; light holes are respectively formed in two sides of the incubation groove body, and an optical detection unit for detecting a sample in the reaction container is arranged on the outer side of each light hole;
the analyzer further comprises a sample reagent tray for carrying sample containers and reagent containers, and a probe mechanism; the probe mechanism is used for rotating to a station of a required sample container or a required reagent container in the sample reagent tray, sucking a sample or a reagent and injecting the sample or the reagent into a corresponding reaction container in the incubation groove body, and sucking, spitting and uniformly mixing liquid in the reaction container;
the probe mechanism comprises a rack arranged on one side of the incubation groove body, a swing arm is arranged above the rack, a spline shaft is arranged between the rack and the swing arm and is arranged at one end of the swing arm, a probe is arranged at the other end of the swing arm, and a probe driving assembly for driving the spline shaft to move is arranged in the rack; a cleaning pool for cleaning the inner wall and the outer wall of the probe is arranged on one side of the probe mechanism;
the probe driving assembly comprises a lifting motor arranged in the rack, a lifting guide rod matched with the spline shaft, and a lifting driving belt wheel which is driven by the lifting motor and drives the spline shaft to move along the lifting guide rod through a synchronous belt, and the lifting motor operates to drive the probe to descend to suck a sample or a reagent;
the reaction cup holder is provided with reaction holes for placing reaction containers along the length direction, light through holes are respectively formed in the positions, corresponding to the reaction holes, of the two sides of the reaction cup holder, the height and the width of each light through hole are matched with the corresponding light through hole on one side, and the light through holes on the two sides are parallel and concentrically arranged;
the cup holder driving assembly comprises a cup holder fixing seat for supporting the reaction cup holder, a fixing seat screw rod for driving the cup holder fixing seat, and a guide rod which is arranged in parallel to the screw rod and plays a role in guiding; elastic pins are respectively arranged at two ends of the cup holder fixing seat, positioning fixing holes matched with the elastic pins are respectively arranged at two ends of the bottom of the reaction cup holder, and a guide groove for inserting the reaction cup holder is formed in the cup holder fixing seat;
the cup holder fixing seat is provided with a screw nut matched with the fixing seat screw and a linear bearing matched with the guide rod;
rotating shaft fixing pieces are respectively arranged on two sides of the incubation groove body, a cylindrical pin is arranged on each rotating shaft fixing piece, a heat preservation cover is arranged at the front end of the incubation groove body, the heat preservation cover is rotatably connected to the cylindrical pin, and a blocking piece used for limiting the rotation angle of the heat preservation cover is arranged on each rotating shaft fixing piece; the heat preservation is covered and has been seted up the ring channel, the ring channel intussuseption is provided with the sealing strip, be provided with the magnet of looks adaptation respectively on heat preservation lid and the hatching cell body.
2. The fully automatic biochemical analyzer according to claim 1, wherein: the optical detection unit is arranged at the bottom of the incubation groove body and comprises a frame body arranged at the bottom of the incubation groove body, a lamp holder arranged at one end of the frame body and a selective optical filter arranged at the other end of the frame body, wherein a photoelectric cell box is arranged at the upper end of the selective optical filter, and radiating fins and radiating fans connected to the radiating fins are arranged below the lamp holder.
3. The fully automatic biochemical analyzer according to claim 1, wherein: the probe mechanism further comprises a rotary positioning optical coupler arranged at the upper end of the rack, and the rotary positioning optical coupler corresponds to the position of a sample or a reagent to be sucked and spit one by one and is used for judging the rotating position of the spline shaft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811326054.1A CN109507438B (en) | 2018-11-08 | 2018-11-08 | Linear incubation groove and full-automatic biochemical analyzer thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811326054.1A CN109507438B (en) | 2018-11-08 | 2018-11-08 | Linear incubation groove and full-automatic biochemical analyzer thereof |
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| Publication Number | Publication Date |
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| CN109507438A CN109507438A (en) | 2019-03-22 |
| CN109507438B true CN109507438B (en) | 2022-06-14 |
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| CN201811326054.1A Active CN109507438B (en) | 2018-11-08 | 2018-11-08 | Linear incubation groove and full-automatic biochemical analyzer thereof |
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| CN113567690A (en) * | 2020-04-28 | 2021-10-29 | 深圳迎凯生物科技有限公司 | Incubation assembly, incubation device and automatic analysis device |
| CN112578136A (en) * | 2020-12-30 | 2021-03-30 | 刘华 | Incubation tank and mobile incubation method |
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