CN207923570U - The centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine - Google Patents
The centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine Download PDFInfo
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- CN207923570U CN207923570U CN201820392824.1U CN201820392824U CN207923570U CN 207923570 U CN207923570 U CN 207923570U CN 201820392824 U CN201820392824 U CN 201820392824U CN 207923570 U CN207923570 U CN 207923570U
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Abstract
A kind of centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, it includes heat source and power source (43), hot blast pipe (45) and backwind tube (44) is arranged in the heater element (41) that the heat source has a cool-bag (42) and is set in the cool-bag between the heat source and film-making chamber；The thermal energy that power source is used to that the heat source to be driven to generate enters the air return of the film-making chamber and the driving film-making intracavitary to the cool-bag through the hot blast pipe；The controller for further including the temperature inductor of the temperature for detecting the film-making intracavitary and controlling the temperature of the film-making intracavitary in turn for acquiring the output valve of the temperature inductor.The temperature in film-making chamber can be controlled by above-mentioned temperature control mechanism, ensures that the testing result of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine is more accurate, and a greater variety of samples can be detected.
Description
Technical field
The utility model is related to liquid-based cell sample manufacturing dyeing installation more particularly to a kind of full-automatic liquid-based cell sample manufacturing dyeing
The centrifugation temperature control mechanism of all-in-one machine.
Background technology
In detection field is dyed in current urinary cancer early screening film-making, there are the automations of film-making staining instruments not
High, most step manual operationss, the disadvantage that process is cumbersome, time-consuming and laborious.Full automatic urine liquid-based film-making dyeing, which has, to be studied, but
Not yet pass through industrialization to examine, in the market currently without the professional equipment of this respect.
Utility model content
The purpose of this utility model is to provide a kind of centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine.
In order to achieve the above object, the technical solution adopted in the utility model is as follows：
A kind of centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine comprising：
Heat source, with a cool-bag (42) and the heater element (41) being set in the cool-bag；
The hot blast pipe (45) and backwind tube (44) being arranged between the heat source and film-making chamber；
Power source (43), for drive the thermal energy that the heat source generates through the hot blast pipe enter the film-making chamber and
Drive the air return of the film-making intracavitary to the cool-bag (42)；
Temperature inductor, the temperature for detecting the film-making intracavitary；And
Controller controls the temperature of the film-making intracavitary for acquiring the output valve of the temperature inductor in turn.
In the centrifugation temperature control mechanism that above-mentioned full-automatic liquid-based cell sample manufacturing dyes all-in-one machine, it is preferable that the power
Source (43) is wind turbine, and the wind turbine is set in the cool-bag (42) of heat source, the air intake of the wind turbine with described time
The outlet of air hose (45) is opposite, outlet air end is opposite with the entrance of the hot blast pipe (45), and the heater element (41) is arranged in institute
It states between wind turbine and the entrance of the hot blast pipe.
In the centrifugation temperature control mechanism that above-mentioned full-automatic liquid-based cell sample manufacturing dyes all-in-one machine, it is preferable that the fever
Element is semiconductor heating element.
In the centrifugation temperature control mechanism that above-mentioned full-automatic liquid-based cell sample manufacturing dyes all-in-one machine, it is preferable that the hot wind
Pipe and backwind tube extend to the film-making intracavitary by the shaft of the first turntable of the film-making intracavitary.
In the centrifugation temperature control mechanism that above-mentioned full-automatic liquid-based cell sample manufacturing dyes all-in-one machine, it is preferable that including a plurality of
The outlet of the hot blast pipe, a plurality of hot blast pipe is arranged in fan-shaped.
Compared with prior art, the utility model at least has the advantages that：
The temperature in film-making chamber can be controlled by above-mentioned temperature control mechanism, ensures full-automatic liquid-based cell sample manufacturing dye
The testing result of color all-in-one machine is more accurate, and can detect a greater variety of samples.
Description of the drawings
Fig. 1 is the complete machine schematic diagram that the full-automatic liquid-based cell sample manufacturing of some embodiments dyes all-in-one machine；
Fig. 2 is its internal structure schematic diagram；
Fig. 3 is the structural schematic diagram of two mechanical arm；
Fig. 4 is the schematic cross-sectional view that sample fills mechanical arm；
Fig. 5 is the structural schematic diagram of work head assembly in two-in-one mechanical arm；
Fig. 6 is the internal structure schematic diagram of work head assembly in two-in-one mechanical arm；
Fig. 7 is the structural schematic diagram of the combination installing mechanism of two mechanical arms；
Fig. 8 is the structural schematic diagram of photo making cup；
Fig. 9 is the decomposing state figure of photo making cup；
Figure 10 is the structural schematic diagram of the first turntable；
Figure 11 is the combination diagram on photo making cup and the first turntable；
Figure 12 is the combination diagram on specimen cup and the second turntable；
Figure 13 is the structural schematic diagram of the driving mechanism of the second turntable；
Figure 14 is the structural schematic diagram of temperature control mechanism.
Specific implementation mode
The utility model is described further with reference to the accompanying drawings and examples.
Referring to Figures 1 and 2, the full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine of some embodiments includes rack 10, rack 10
With sample chamber 12 and film-making chamber 11 arranged side by side, it is provided with the first turntable 111 in film-making chamber 11, is provided in sample chamber 12
Second turntable 121, rack 10 are additionally provided with the driving mechanism 123 of the driving mechanism 114 and the second turntable 121 of the first turntable 111.
Film-making chamber 11 and sample chamber 12 are further provided with chamber lid 11 ' and 12 '.Rack 10 is further provided with to be held for placing dyeing liquor
Receiving lattice 13, display device 14, emergency switch 15, waste collection chamber 16 and the control device 50 of device.Wherein, 14 He of display device
Control device 50 is using the device to become one, such as the programmable logic controller (PLC) (PLC) with display.
The full-automatic liquid-based cell sample manufacturing of some embodiments dyes all-in-one machine：Several specimen cups 122, several photo making cups
112, several suction nozzles 113, add for picking up suction nozzle 113 and sample being transferred to the sample of corresponding photo making cup 112 from specimen cup 122
Note mechanical arm 20, for filling dyeing liquor into photo making cup 112 and drawing the two-in-one mechanical arm 30 of discharge waste liquid.If exsiccata
On the second turntable 121 that cup 122 is arranged in sample chamber 12, for storing pending sample.The setting of several photo making cups 112 exists
On the first turntable 111 in film-making chamber 11, for carrying out film-making and dyeing processing to sample.Several suction nozzles 113 are arranged first
It on turntable 111, is combined by filling mechanical arm 20 with sample, to draw specimen fluids, sample filling mechanical arm 20 has handled one
After sample in a specimen cup 122, suction nozzle can be replaced automatically, to avoid the friendship between sample while realizing automatic business processing
Fork influences.
The full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine of some embodiments further includes temperature control mechanism 40, temperature control mechanism 40 and institute
The connection of film-making chamber 11 is stated, to maintain the temperature in film-making chamber 11 in the temperature of setting.
Control device 50 is used for：Control the first turntable 111, the second turntable 121, sample filling mechanical arm 20, two-in-one machine
Tool arm 30 presses program work, carries out centrifugal concentrating to the sample in specimen cup 122 first, transfers to corresponding photo making cup 112,
It is then centrifuged for film-making and dyeing.Specifically process includes：Second turntable first, 121 high-speed rotation, in each specimen cup 122
Sample carries out centrifugal concentrating, next, draw the waste liquid at the middle and upper levels of specimen cup 122 by two-in-one mechanical arm 30, then sample
Filling mechanical arm 20 picks up sample of the suction nozzle 113 after drawing concentration in specimen cup 122 and is transferred in photo making cup 112, at every place
After having managed a sample, suction nozzle is dropped into waste collection chamber 16 automatically, then picks up new suction nozzle and handles next sample, until
Sample transfer finishes, and following first turntable 111 rotates, and carries out centrifugation film-making, then by two-in-one mechanical arm 30 to film-making
Cup 112 injects dyeing liquor, centrifugation dyeing, then the waste liquid in photo making cup is discharged by two-in-one mechanical arm 30, finally in film-making
Film-making is completed on the wave carrier piece of cup.
Fig. 2 to Fig. 4 is please referred to, sample filling mechanical arm 20 includes：Sample fills component 21, and the first cantilever 22, first drives
Motivation structure 23 and the second driving mechanism 24.
Wherein, there is sample filling component 21 inner tube 212 and outer tube 213, the lower end setting suction nozzle of said inner tube 212 to connect
Mechanism 211, upper end are fixedly connected with the first sliding block 215, and the inner cavity 214 of inner tube 212 is also connected with tracheae (not shown), the tracheae
The suction nozzle for being connected to suction nozzle bindiny mechanism 211 is connect with air source, sucks or be discharged sample by pressure control suction nozzle.It is described outer
Pipe 213 is sheathed on the periphery of said inner tube 212, and the upper end of outer tube 213 passes through first sliding block 215 and 217 phase of a locating part
Right, when sliding block 215 drives inner tube 212 and outer tube to move upward to certain position, upper end and the locating part 217 of outer tube 213 offset
It touches, outer tube 213 can not further up, and the first sliding block 215 drives 212 further uplink of inner tube then to make outer tube 213 and inner tube
212 relative motions make the suction nozzle for being connected to 212 lower end of inner tube fall off under the extruding of 213 lower end of outer tube, automatic to realize
Remove suction nozzle.The sample, which fills component 21, also has the elastic component 216 for driving the outer tube 213 to reset, when 215 band of the first sliding block
After dynamic inner tube 212 and outer tube 213 move downward, locating part 217 is released from the limitation of the upper end of outer tube 213, and elastic component 216 is then
Driving outer tube 213 moves upwards reset so that and the suction nozzle bindiny mechanism 211 of 212 lower end of inner tube can be combined with suction nozzle again,
Again suction nozzle 113 is picked up.
As a kind of preferred embodiment, suction nozzle bindiny mechanism 211 includes the cushion rubber for being set in 212 periphery of said inner tube.It picks up
When taking suction nozzle, the first sliding block 15 driving inner tube 212 is downwardly into the oral area of suction nozzle, passes through the cushion rubber and the suction of 212 periphery of inner tube
Suction nozzle is fixed on the lower end of the inner tube 212 by the interference fit of the inner wall in mouthpiece portion.
Sample filling component 21 is further provided with two limit switches 25,26, wherein a limit switch is for positioning
Sample fills the raising height of component 21, another limit switch is used to position the opposite position of the outer tube 213 and inner tube 212
It moves.Optoelectronic switch, magnetic switch or mechanical touch-pressure switch etc. may be used in limit switch.
Sample filling component 21 is supported in main support 60 by the first cantilever 22.
First driving mechanism 23 is for driving first sliding block 215 to move up and down.First driving mechanism 23 includes：Setting
The is arranged on the downside of the first cantilever 22 first substrate 231 opposite with the end of first cantilever 22, the first substrate 231
One support wheel 232；The guide rod 233 for the first sliding block 215 being arranged between the first substrate 231 and the first cantilever 22；Peace
The first motor 235 loaded on the first cantilever 22；And the first motor 235 of connection shaft and first support wheel 232 the
One transmission belt 234, first sliding block 215 are fixed on the first transmission belt 234.
Second driving mechanism 24 is for driving the movement of the first cantilever 22 extremely to refer to sample filling component 21 positioning
Positioning is set.Second driving mechanism 24 includes：The first driven wheel 242, Yi Jishe in combination bearing 70 is arranged in second motor 242
Set the second transmission belt 243 between the first driven wheel 241 and the shaft of the second motor 242.
Sample filling mechanical arm 20 further includes a kind of control device, and the control device by sample for filling to corresponding
After in photo making cup, the air pressure for continuing to control in said inner tube 212 so that the sample is more between the suction nozzle and the photo making cup
Secondary repeated exchanged, which is realized, stirs sample, which can be an independent device, can also be filled with control above-mentioned
It sets 50 and shares same hardware.
Fig. 2, Fig. 3, Fig. 5 and Fig. 6 are please referred to, the two-in-one mechanical arm 30 includes：Work head assembly 31, the second cantilever
32, third driving mechanism 33 and the 4th driving mechanism 34.Wherein, work head assembly 31 has waste liquid suction pipe 313, at least one dye
Color liquid filler pipe 312 and combination head 311, the combination head 311 are provided with several appearances parallel with the axis of combination head 311
Receive hole 310, waste liquid suction pipe 313 and at least one dyeing liquor filler pipe 312 are installed on several receiving holes 310 to group
It is integrated.
As a kind of preferred embodiment, a receiving hole in several receiving holes 310 is located at 311 end of the combination head
At the center in face, remaining receiving hole be distributed in using the center of 311 end face of the combination head as on the circumference in the center of circle, the waste liquid is inhaled
Pipe 313 is installed in the receiving hole at center.The quantity of dyeing liquor filler pipe 312 is identical as the type of dyeing liquor, end point
It is not connected with corresponding dyeing liquid container by pump, by controlling corresponding pump in use, aspirates and contaminate from corresponding dyeing liquor container
Color liquid is injected from the front end of dyeing liquor filler pipe in target photo making cup.And the end of waste liquid suction pipe 313 is then held by pump and waste liquid
Device connects, after centrifugation film-making, centrifugation dyeing, by controlling the pump to connect with waste liquid suction pipe 313, by the waste liquid in photo making cup
Discharge.It further is connected with casing 314 in the rear end of combination head 311, storage protection is carried out to relevant liquid line.
The lower end of the combination head 311 is further designed as inversed taper platform structure, the waste liquid suction pipe 313 is from the combination
First 311 lower end protrudes, and the lower end (i.e. front end) of at least one dyeing liquor filler pipe 312 is located in the combination head 311.
Work head assembly 31 is supported in main support 60 by the second cantilever 32.
Third driving mechanism 33 is for driving the work head assembly 31 to move up and down.Third driving mechanism 33 includes：If
The second substrate 331 opposite with the end of second cantilever 32 in the downside of second cantilever 32 is set, on the second substrate 331
Second support wheel 332 is set；The second sliding block between the second substrate 331 and the second cantilever 32 is set by guide rod
333, the work head assembly 31 is directly or indirectly connect with second sliding block 333；It is installed on the third horse of the second cantilever 32
Up to 334；And the third transmission belt 335 of the shaft and second support wheel 332 of connection third motor 334, described second slides
Block 333 is fixed on the third transmission belt 335.
Further limit switch (not shown) can be set for positioning the work head group in two-in-one mechanical arm 30
The up and down motion terminal of part 31.Optoelectronic switch, magnetic switch or mechanical touch-pressure switch etc. may be used in limit switch.
4th driving mechanism 34 is for driving the movement of the second cantilever 32 to position the work head assembly 31 to specified
Position comprising the second driven wheel 343 in combination bearing 70, and the second driven wheel 343 of connection is arranged in the 4th motor 341
With the 4th transmission belt 342 of the shaft of the 4th motor 341.
Fig. 7 is please referred to, as a kind of preferred embodiment, the sample filling mechanical arm 20 and the two-in-one mechanical arm 30
It is installed on rack by combining installing mechanism, the combination installing mechanism includes that main support 60 square on the table is arranged, with
And the combination bearing 70 being arranged on the main support 60, the combination bearing 70 include tubular base 72, are sheathed on the pipe
Tubular outer shaft 71 outside shape pedestal 72 and the inner shaft 73 being inserted in the tubular base 72, the tubular base 72 are installed in institute
Main support 60 is stated, the sample filling mechanical arm 20 and the two-in-one mechanical arm 30 pass through the first cantilever 22 and the second cantilever 32
It is installed in the inner shaft 73 and the outer shaft 71 respectively.It designs whereby, complete machine structure can be made compacter, neatly.
Fig. 8 to Figure 11 is please referred to, each photo making cup 112 includes third substrate 1121, is arranged in the third substrate
The collector tube 1124 of 1121 sides and it is inserted in the glass slide being connected in the third substrate 1121 and with the collector tube 1124
1125, several photo making cup holding tanks 1111 of setting at the outer of first turntable 111, several photo making cups 112 correspond to peace
Loaded on being pivotally connected with the side wall of place holding tank 1111 in several photo making cup holding tanks 1111, by the glass slide of photo making cup 112
1125 are transversely supported on first turntable 1111.Compared in existing production facility by the design of glass slide vertical supporting and
Speech, the sample of the glass slide of above-mentioned cross-brace after film-making on glass slide are more uniform.More specifically, in collector tube 1124
There is outwardly projecting prominent button 1123 in lower end, is rotated behind the installation position that 1124 lower end of collector tube is inserted on third substrate 1121 described in making
Collector tube 1124 is connected on third substrate 1121 by the 1123 button bit cooperation corresponding on substrate of prominent button.In third substrate 1121
Both sides be provided with prominent axis 1122, be correspondingly arranged on recess portion 1112 in the cell wall of holding tank 1111, match with the prominent axis 1122
Photo making cup 112 is supported in holding tank 1111 by conjunction.113 be suction nozzle loading hole in Figure 10.
Further, the first turntable 111 under static state, has 1 to 8 between the glass slide and horizontal plane of photo making cup 112
The angle of degree.By the design, not only sample evenly can be obtained in glass slide, and convenient for drawing the mark in photo making cup
This waste liquid generated after film-making and dyeing.
Fig. 2 and Figure 12 are please referred to, several specimen cup holding tanks are set at the outer of the second turntable 121, each specimen cup 122 is right
It should be arranged in several specimen cup holding tanks.
In the utility model, sample first centrifugal concentrating is carried out in sample chamber 12, then transfer in film-making chamber 11 into
Row film-making and dyeing.
In order to realize high speed centrifugation concentration and the high accuracy positioning of sample, it is special to be devised for the turntable in sample chamber
Driving mechanism.Figure 13 is please referred to, the driving mechanism 123 of the second turntable 121 includes two motors 1231,1234, one of horse
Up to 1234 for driving 121 high-speed rotation of the second turntable, the high speed centrifugation concentration of sample is realized, another motor 1231 is for driving
Dynamic second turntable 121, which slowly runs, positions target specimen cup to designated position, then fills mechanical arm by sample by sample
It is transferred in the photo making cup in film-making chamber.
In an exemplary embodiment, the turntable 121 in the sample chamber shaft be arranged unilateral bearing 1233, it is described another
Motor 1231 drives the second turntable 121 by belt 1232 drives the unilateral bearing 1233.It, can using above-mentioned design
Another motor 1231 rotation is driven in avoiding high speed centrifugation from handling, and harmful effect is generated to equipment.
For film-making and dyeing course, centrifugation is can reach using stepper motor and is required, therefore first turn in film-making chamber
The driving mechanism 114 of disk 111 uses single motor drive mechanism.
Figure 14 is please referred to, the temperature control mechanism (centrifuging temperature control mechanism) 40 includes heat source, which there is a heat preservation to hold
Device 42 and the heater element 41 being set in the cool-bag 42.Further include hot blast pipe 45 and backwind tube 44, they are arranged in institute
It states between heat source and film-making chamber.Further include power source 43, for drive the thermal energy that the heat source generates through the hot blast pipe 45 into
Enter the air return of the film-making chamber and the driving film-making intracavitary to the cool-bag 42.It further include temperature inductor
(not shown), the temperature for detecting the film-making intracavitary.Further include controller (not shown), it is described for acquiring
The output valve of temperature inductor and then the temperature for controlling the film-making intracavitary.
As a kind of embodiment, the power source 43 is wind turbine, and the wind turbine is set to the cool-bag 42 of heat source
In, the air intake of the wind turbine is opposite with the outlet of the backwind tube 44, outlet air end is opposite with the entrance of the hot blast pipe 45, institute
Heater element 41 is stated to be arranged between the wind turbine and the entrance of the hot blast pipe 45.
The heater element 41 uses semiconductor heating element, small, easy for installation.
The hot blast pipe 45 and backwind tube 44 extend to the film-making chamber by the shaft of the first turntable of the film-making intracavitary
Interior, the rotation of the first turntable does not interfere with temperature control mechanism normal work.Further, temperature control mechanism 40 includes a plurality of hot blast pipe
45, the outlet of a plurality of hot blast pipe 45 is arranged in fan-shaped, and the temperature in film-making chamber everywhere can be made more consistent, detection is made to tie
Fruit is more acurrate.
The full-automatic liquid-based cell sample manufacturing colouring method of some embodiments is dyed using above-mentioned full-automatic liquid-based cell sample manufacturing
All-in-one machine the described method comprises the following steps：
121 high-speed rotation of the second turntable is controlled to concentrate specimen centrifuge；
First turntable, 111 and second turntable 121 is located in designated position；
Sample shifts：Sample filling mechanical arm 20, which picks up new suction nozzle 113 and draws sample from specimen cup, is transferred to working position
Photo making cup 112 in, then remove suction nozzle 113；
Next specimen cup and photo making cup are turned into working position, repeat above-mentioned sample transfer step；It is complete to repeat the step
It is shifted at sample；
The rotation of the first turntable 111 is controlled, film-making is centrifuged；And
Coloring agent is filled to each photo making cup by two-in-one mechanical arm 30, centrifugation dyeing passes through two-in-one mechanical arm 30
The waste liquid in photo making cup is discharged.
The utility model is described in detail above by specific embodiment, these detailed description are only limited to
The content of the utility model is helped skilled in the art to understand, the limit to scope of protection of the utility model can not be interpreted as
System.Those skilled in the art should all wrap various retouchings, the equivalent transformation etc. that said program carries out under the utility model design
Containing within the protection scope of the present utility model.
Claims (5)
1. a kind of centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine, which is characterized in that the centrifugation temperature control
Mechanism includes：
Heat source, with a cool-bag (42) and the heater element (41) being set in the cool-bag；
The hot blast pipe (45) and backwind tube (44) being arranged between the heat source and film-making chamber；
Power source (43), for driving the thermal energy that the heat source generates to enter the film-making chamber and driving through the hot blast pipe
The air return of the film-making intracavitary is to the cool-bag (42)；
Temperature inductor, the temperature for detecting the film-making intracavitary；And
Controller controls the temperature of the film-making intracavitary for acquiring the output valve of the temperature inductor in turn.
2. the centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, feature exist
In the power source (43) is wind turbine, and the wind turbine is set in the cool-bag (42) of heat source, the air inlet of the wind turbine
End is opposite with the outlet of the backwind tube (44), outlet air end is opposite with the entrance of the hot blast pipe (45), the heater element
(41) it is arranged between the wind turbine and the entrance of the hot blast pipe.
3. the centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, feature exist
In the heater element is semiconductor heating element.
4. the centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, feature exist
In the hot blast pipe and backwind tube extend to the film-making intracavitary by the shaft of the first turntable of the film-making intracavitary.
5. the centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine according to claim 1, feature exist
In, including a plurality of hot blast pipe, the outlet of a plurality of hot blast pipe is in fan-shaped arrangement.
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| CN201820392824.1U CN207923570U (en) | 2018-03-21 | 2018-03-21 | The centrifugation temperature control mechanism of full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108168986A (en) * | 2018-03-21 | 2018-06-15 | 深圳市鹏医疗仪器有限公司 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108168986A (en) * | 2018-03-21 | 2018-06-15 | 深圳市鹏医疗仪器有限公司 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
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