CN107290562B - A kind of automatic sample handling system for the detection of sample cell high throughput - Google Patents
A kind of automatic sample handling system for the detection of sample cell high throughput Download PDFInfo
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- CN107290562B CN107290562B CN201710725467.6A CN201710725467A CN107290562B CN 107290562 B CN107290562 B CN 107290562B CN 201710725467 A CN201710725467 A CN 201710725467A CN 107290562 B CN107290562 B CN 107290562B
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- 238000001514 detection method Methods 0.000 title claims abstract description 31
- 230000007246 mechanism Effects 0.000 claims abstract description 53
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- 239000000758 substrate Substances 0.000 claims description 21
- 230000001360 synchronised effect Effects 0.000 claims description 18
- 230000033001 locomotion Effects 0.000 claims description 13
- 230000005693 optoelectronics Effects 0.000 claims description 12
- 238000009434 installation Methods 0.000 claims description 7
- 238000003908 quality control method Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 230000000630 rising effect Effects 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 230000001413 cellular effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 281
- 210000004027 cell Anatomy 0.000 description 86
- 238000005070 sampling Methods 0.000 description 21
- 238000010586 diagram Methods 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
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- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
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Abstract
The invention discloses a kind of automatic sample handling systems for the detection of sample cell high throughput, including the sample disc for placing multitube sample cell, the sample disc is arranged on sample introduction plate by rotating mechanism, the sample introduction plate is connect by passing in and out storehouse driving mechanism with sample introduction back box, the sample disc is under the action of passing in and out storehouse driving mechanism relative to sample introduction back box warehouse entry or export, in warehouse entry state, multitube sample cell in the sample disc promoted with the cooperation of sample cell hoisting mechanism respectively inhales sample, in export state, multitube sample cell in the sample disc can be replaced.Sample disc of the invention is in warehouse entry state, it can cooperate with sample cell hoisting mechanism, realize sample cell sample introduction in sample disc, in export state, it can be by sample disc by being taken out in system and convenient for the replacement of sample cell, the present invention has the function of that sample disc can be taken off, automate disengaging storehouse and sample cell rotational positioning and promote sample introduction, effectively realizes the continuous detection of high throughput of multitube sample cell.
Description
Technical field
The invention belongs to blood cell analysis equipment technical field, in particular to it is a kind of for sample cell high throughput detection
Automatic sample handling system.
Background technique
The vitro diagnosis assays instrument of blood, such as blood cell analyzer and stream type cell analyzer, in clinical user
Daily use in can often encounter the tests of a large amount of samples, such as the detection of blood routine, the analysis of lymphocyte subgroup, average daily inspection
Measurement can reach hundreds of pipe samples.For clinical user, automation equipment, intelligence are improved, is reduced to operator's time
Occupancy, be the important core bright spot of instrument.
It when cytoanalyze carries out sample diagnosis, needs through sample sampling device from heparin tube or test tube, draws
The samples such as the cell after a certain amount of fluorescent marker, and pass through sample introduction capillary or sampling needle；The sample of absorption is injected again thin
Born of the same parents' analysis cell or flow chamber, and successively recognized by instrument detection.Continuous, automation detection for various quality control, usually
Also to cooperate the motion control device of various dimensions, and be mutually linked cooperation, the full-automation of sample to be analysed is taken to realize
Sample and analysis.
In this professional domain, forefathers have been carried out some explorations, such as the sampling device in autosampler may be designed as
It is mobile in lateral X axis, longitudinal direction Y axis and vertical Z axis three degree of freedom, but belong to universal design, efficiency is lower and equal
Biggish space can be occupied.
Such as the Chinese patent that number of patent application is 201210133808.8, propose comprising sample tray and positioning knob,
The automatic sampling scheme of pallet rotating actuator, pallet lift transmission mechanism is tested for 96 holes and 384 holes, uses sample
Product pallet lift, horizontal rotation control mode, but be not suitable for the clinical bloods sample such as heparin tube and 5mL flow cytometer showed pipe
Analysis.
Such as number of patent application is the Chinese patent of 201210088038.X, proposing for cellanalyzer can be to sample
Product are loaded, pull, mixing, puncturing the integrated apparatus of sampling, unloading, propose full-automatic feasible solution,
But the device uses the scheme of sample cell linear movement, whole to occupy a large amount of spatial volume, such as sample cell increases from 10 pipes
The increase of system bulk at double will be brought to 20 pipes.
For another example the Chinese patent that number of patent application is 201410221782.1, proposes for the full-automatic of flow cytometer
Sample introduction mechanism, disclose can inside and outside two circle place the rotating disk of samples, control sample needle along X to doing horizontal reciprocating movement
Driving mechanism (sampling for Internal and external cycle), control rotating disk do the driving mechanism that Z-direction moves back and forth vertically.Scenario-frame is tighter
It gathers, but how the program automates the scheme of rotation selection sample cell, and the fixed not side of rotating disk without reference to rotating disk
Just clinical user mass places sample test cell, still there is biggish room for improvement.
Therefore, how to facilitate user quickly to place sample cell (including heparin tube or test tube), save spatial volume premise
Selection is individually addressed to sample feeding pipe in the lower flux (such as more than 30 pipes) for increasing the continuous detection sample cell of single, realization, and full
Pollution-free, personnel safety the principle that podiatrist treats is the main target for automating sample sampling device.
Summary of the invention
It is an object of the invention to: in view of the above problems, one kind is provided and puts forth effort on solution blood cell analyzer
In the clinical instruments such as stream type cell analyzer, automation shifts sample cell with high throughput, individually addressing selection, continuously
Property sample introduction require for sample cell high throughput detection automatic sample handling system.
The technical scheme of the present invention is realized as follows: a kind of automatic sample handling system for the detection of sample cell high throughput,
Including the sample disc for placing multitube sample cell, the sample disc is arranged on sample introduction plate by rotating mechanism, and feature exists
Connect by disengaging storehouse driving mechanism with sample introduction back box in: the sample introduction plate, be arranged in sample disc on the sample introduction plate into
Multitube relative to sample introduction back box warehouse entry or export under the action of export driving mechanism, in warehouse entry state, in the sample disc
Sample cell carries out promotion suction sample with the cooperation of sample cell hoisting mechanism respectively can be in the sample disc in export state
Multitube sample cell is replaced.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the disengaging Cang Qudongjigoubao
Line slide rail mould group, support post and linear drive apparatus are included, the support post is fixedly connected in sample introduction back box, described
Line slide rail mould group links together with support post, and the sample introduction plate is slidably arranged in line slide rail mould group and and straight line
Driving device connection, the sample introduction plate complete the linearly operating of warehouse entry and export under the action of linear drive apparatus.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the sample introduction plate includes sample introduction plate
Substrate and the protrusion interconnecting piece of bottom, the sample introduction plate substrate middle part are the platform of recess, and the prominent interconnecting piece is dashed forward downwards
For recess platform side wall and connect with linear drive apparatus, be respectively set in the recess platform two sides of the sample introduction plate substrate
There is the support post of parallel arrangement, the line slide rail mould group being arranged on the support post forms convex with sample introduction plate substrate two sides
Platform corresponding matching, the line slide rail mould group are used for linear slide of the sample introduction plate substrate relative to support post.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the linear drive apparatus include
Linear drive motor, synchronous toothed belt, driving wheel and driven wheel, the linear drive motor are fixedly connected on support post,
The driving wheel and the power output end of linear drive motor connect, and the driven wheel is rotatably arranged on support post,
On driving wheel and driven wheel, the synchronous toothed belt passes through connection component and sample introduction plate for synchronous toothed belt both ends solderless wrapped connection
Prominent interconnecting piece connects, and the sample introduction plate is moved synchronously with synchronous toothed belt.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the rotating mechanism include rotation
Transmission device and rotation drive device, the rotating transmission device include the sample disc button being from top to bottom sequentially arranged, space disc,
Swivel bearing, synchromesh gear, rotation code-disc and end cap, the sample disc button, space disc, synchromesh gear, rotation code-disc and
End cap is fixed together composition overall structure, the sample disc button and sample disc detachable connection, institute by connector
The bottom that end cap is set to rotation code-disc is stated, the synchromesh gear and rotation code-disc are socketed on swivel bearing, and pass through rotation
Bearing and sample introduction plate are rotatablely connected.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the rotation drive device are fixed
On sample introduction plate, the lateral position of swivel bearing, the rotation drive device drives sample disc by rotating transmission device
Rotation comprising rotary drive motor, flat-toothed belt and rotating driver, the rotary drive motor are fixed at sample introduction
On plate, and the power output shaft of the rotary drive motor passes through sample introduction plate and connect with rotating driver, the flat-toothed belt
Both ends solderless wrapped connection is on synchromesh gear and rotating driver, to drive synchromesh gear to rotate.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, is provided on the sample introduction plate
Code disc optoelectronic sensor and positioning photoelectric sensor, the code disc optoelectronic sensor and rotation code-disc cooperation, for judging rotation
The rotational angle of transmission device, the positioning photoelectric sensor and the detent fit being arranged on end cap, for determining rotation
The initial position of transmission device, the synchronous toothed belt is laterally additionally provided with another positioning photoelectric sensor, for judging sample introduction
The position of plate, the linear drive motor, rotary drive motor, code disc optoelectronic sensor and two positioning photoelectric sensors point
It is not connect with the drive control plate being arranged in sample introduction back box, the drive control plate is for controlling linear drive motor and rotation
The rotation of driving motor, and read the motion information that code-disc photoelectric sensor and two positioning photoelectric sensors obtain.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, sets in sample introduction back box periphery
It is equipped with warehouse shell, the warehouse shell includes bottom shell, front panel, back shroud and upper cover, the bottom shell installation
To the planar base of sample introduction back box, the front panel is that circular arc facade and internal diameter are greater than sample dish external diameter, and install into
The front of template, the back shroud are installed to the left and right side of sample introduction back box and the back side, and the upper cover is installed by rotation hinge
To back shroud upper surface, under sample introduction plate export state, the upper cover opens up and then proposes sample disc, sample introduction plate into
Under the state of storehouse, the warehouse shell forms relatively closed environment.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the sample disc is integrally in cylinder
Shape structure is provided with several cellular through-holes of a circle in the sample disc excircle, and the via bottoms gradually taper up to be formed
It is used to support the support portion of sample bottom of the tube, the opening of the via bottoms, which is greater than, is arranged below sample disc sample cell elevator
The sample lift lever of structure is used to support and promotes the support promotion end of sample cell, in lifting process, the sample lift lever
Support promote end and pass through through-hole in sample disc, and support the sample bottom of the tube being placed in through-hole and make its rising, and
Make sample cell upper end opening portion and swab bottom is fitted close to form sealing, the sample cell and swab are transported tight fit is synchronous
Opposing seal state is remained during dynamic.
Automatic sample handling system of the present invention for the detection of sample cell high throughput, the sample disc include mutually interconnecting
The sample disc upper cover and sample cell bee slotted disk being connected together are provided with several sample pipe through-holes in the sample disc cover rim,
Several sample pipe through-holes are corresponded and are connected to several sample cell bee slots that sample cell bee slotted disk edge is arranged, in institute
It states and is provided with handle, the sample cell bee slotted disk bottom and rotating mechanism detachable connection in sample disc on lid.
The present invention can pass in and out the state in storehouse by the way that sample disc to be designed as, and make sample disc in warehouse entry state, can be with sample
The cooperation of quality control hoisting mechanism, realizes the sample introduction of sample cell in sample disc, in addition, sample disc is in export state, it can be by sample
By taking out in system and convenient for the replacement of sample cell, there is disk sample disc can be taken off, automate disengaging storehouse and sample by the present invention
Pipe rotational positioning and the function of promoting sample introduction effectively realize the continuous detection of high throughput of multitube sample cell.
Detailed description of the invention
Fig. 1 and Fig. 2 is structural schematic diagram of the invention.
Fig. 3 is structural schematic diagram of the sample disc in warehouse entry state in the present invention.
Fig. 4 is structural schematic diagram of the sample disc in export state in the present invention.
Fig. 5 is the structural schematic diagram for passing in and out storehouse driving mechanism in the present invention and connecting with sample introduction back box.
Fig. 6 is the structural schematic diagram of linear drive apparatus in the present invention.
Fig. 7 is a kind of structural schematic diagram that the rotating transmission device of structure is connect with sample introduction plate in the present invention.
Fig. 8 is the cross-sectional view of Fig. 7.
Fig. 9 is the structural schematic diagram of rotating transmission device in Fig. 7.
Figure 10 is the cross-sectional view of Fig. 9.
Figure 11 is the structural schematic diagram of swivel bearing in Figure 10.
Figure 12 is the structural schematic diagram that the rotating transmission device of another structure in the present invention is connect with sample introduction plate.
Figure 13 is the structural schematic diagram of rotating transmission device in Figure 12.
Figure 14 is the structural schematic diagram of sample disc in the present invention.
Figure 15 is that sample cell is placed in the schematic diagram in sample disc in the present invention.
Figure 16 is the schematic diagram of the sample cell hoisting mechanism and sample disc cooperation in the present invention.
Figure 17 is the sample disc position view in warehouse entry and export respectively in the present invention.
Figure 18 is the schematic diagram that sample cell hoisting mechanism promotes sample cell in the present invention.
Marked in the figure: 1 is sample cell, 2 be sample disc, and 3 be sample introduction plate, and 4 be sample introduction back box, and 5 be sample cell hoisting mechanism,
6 be line slide rail mould group, and 7 be support post, and 8 be linear drive apparatus, and 9 be rotating transmission device, and 10 be rotation drive device,
11 be code disc optoelectronic sensor, and 12 be positioning photoelectric sensor, and 13 be drive control plate, and 14 be warehouse shell, and 15 be swab, 16
It is sampling needle rack for sampling needle, 17,18 be substrate, and 19 be swab sliding equipment, and 21 be sample disc upper cover, and 22 be sample cell bee
Slotted disk, 23 be handle, and 31 be sample introduction plate substrate, and 32 be prominent interconnecting piece, and 33 be platform, and 41 be planar base, and 51 mention for sample
Rising stem, 81 be linear drive motor, and 82 be synchronous toothed belt, and 83 be driving wheel, and 84 be driven wheel, and 91 be sample disc button, and 92 are
Space disc, 93 be swivel bearing, and 94 be synchromesh gear, and 95 be rotation code-disc, and 96 be end cap, and 97 be positioning pin, and 101 drive for rotation
Dynamic motor, 102 be flat-toothed belt, and 103 be rotating driver, and 141 be bottom shell, and 142 be front panel, and 143 be back shroud,
144 be upper cover, and 211 be sample pipe through-hole, and 221 be sample cell bee slot, and 511 promote end for support, and 931 be follower shaft,
932 be deep groove ball bearing, and 933 be axle sleeve, and 934 be screw.
Specific embodiment
With reference to the accompanying drawing, the present invention is described in detail.
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
As shown in Figs 1-4, a kind of automatic sample handling system for the detection of sample cell high throughput, including for placing multitube sample
The sample disc 2 of quality control 1, the sample cell 1 are the containment devices of cell analysis sample to be tested, are often the cylindrical tube of bottom hemispherical
Shape structure, it includes but be not limited to medical vacuum heparin tube, flow cytometer showed 5mL sample cell and Bioexperiment with 1~5mL be centrifuged
Pipe etc., the sample disc 2 by rotating mechanism be arranged on sample introduction plate 3, the sample introduction plate 3 by disengaging storehouse driving mechanism with into
Sample back box 4 connects, the sample introduction back box 4 generally four sides box body structure, wherein front is transported to the disengaging storehouse for sample introduction plate 3
It is dynamic, be arranged in the sample disc 2 on the sample introduction plate 3 under the action of passing in and out storehouse driving mechanism relative to 4 warehouse entry of sample introduction back box or
Export is provided with warehouse shell 14 in 4 periphery of sample introduction back box, and the warehouse shell 14 includes bottom shell 141, front panel
142, back shroud 143 and upper cover 144,41 lower section of planar base of the installation of bottom shell 141 to sample introduction back box 4 are described
Front panel 142 is circular arc facade and internal diameter is greater than 2 outer diameter of sample disc, and is installed to the front of sample introduction plate 3, the back shroud
To the left and right side and the back side of sample introduction back box 4, the upper cover 144 is installed by rotation hinge to table on back shroud 143 for 143 installations
Face, under 3 export state of sample introduction plate, the upper cover 144 opens up and then proposes sample disc 2, can be to the sample disc 2
On multitube sample cell 1 replaced, under 3 warehouse entry state of sample introduction plate, the warehouse shell 14 forms relatively closed environment,
Multitube sample cell 1 in the sample disc 2 promoted with the cooperation of sample cell hoisting mechanism 5 respectively inhales sample, passes through warehouse shell
Setting, guarantee that the promotion sample introduction of sample cell is detected in the environment of relative closure, both can avoid dirt of the environment to sample
Dye also can avoid damage of the high-speed moving part to medical staff.
Wherein, disengaging storehouse driving mechanism includes line slide rail mould group 6, support post 7 and linear drive apparatus 8,
The support post 7 is fixedly connected in sample introduction back box 4, and the line slide rail mould group 6 links together with support post 7, institute
It states sample introduction plate 3 to be slidably arranged in line slide rail mould group 6 and connect with linear drive apparatus 8, the sample introduction plate 3 drives in straight line
The linearly operating of warehouse entry and export is completed under the action of dynamic device 8；The sample introduction plate 3 is main motion carrier comprising into
Template substrate 31 and the protrusion interconnecting piece 32 of bottom, the generally rectangular sheet metal structural of the sample introduction plate substrate 31, middle part are
The platform 33 of recess, the rotating mechanism are fixed to the middle part of recess platform 33, and the prominent interconnecting piece 32 protrudes downward from recessed
It falls into the side wall of platform 33 and is connect with linear drive apparatus 8, set respectively in 33 two sides of recess platform of the sample introduction plate substrate 31
It is equipped with the support post 7 of parallel arrangement, the spacing of two support posts 7 is equal to 31 two sides boss distance of sample introduction plate substrate, described
The boss corresponding matching that the line slide rail mould group 6 being arranged on support post 7 and 31 two sides of sample introduction plate substrate are formed, the straight line are sliding
Rail mould group 6 is used for linear slide of the sample introduction plate substrate 31 relative to support post 7.
As it can be seen in figures 5 and 6, the linear drive apparatus 8 includes linear drive motor 81, synchronous toothed belt 82, driving wheel
83 and driven wheel 84, the linear drive motor 81 be fixedly connected on support post 7, the driving wheel 83 and linear drives electricity
The power output end of machine 81 connects, and the driven wheel 84 is rotatably arranged on support post 7,82 liang of the synchronous toothed belt
Hold solderless wrapped connection on driving wheel 83 and driven wheel 84, the synchronous toothed belt 82 is connected by connection component and the prominent of sample introduction plate 3
Portion 32 connects, and the sample introduction plate 3 is moved synchronously with synchronous toothed belt 82, and then completes the movement of sample introduction plate warehouse entry and export
Control.
As is seen in figs 7-10, the rotating mechanism is used to cooperate with sample disc 2, provides accurate rotational positioning and control,
It includes rotating transmission device 9 and rotation drive device 10, and the rotating transmission device 9 includes the sample being from top to bottom sequentially arranged
Product disk buckles 91, space disc 92, swivel bearing 93, synchromesh gear 94, rotation code-disc 95 and end cap 96, the sample disc button 91,
Space disc 92, synchromesh gear 94, rotation code-disc 95 and end cap 96 are fixed together composition overall structure by connector,
The sample disc button 91 and 2 detachable connection of sample disc, and realize synchronous rotation, the end cap 96 is set to rotation code-disc 95
Bottom, the synchromesh gear 94 and rotation code-disc 95 are socketed on swivel bearing 93, and pass through swivel bearing 93 and sample introduction plate 3
Rotation connection；The rotation drive device 10 is fixed on sample introduction plate 3, the lateral position of swivel bearing 93, the rotation driving
Device 10 drives sample disc 2 to rotate by rotating transmission device 9 comprising rotary drive motor 101, flat-toothed belt
102 and rotating driver 103, the rotary drive motor 101 is fixed on sample introduction plate 3, and the rotary drive motor
101 power output shaft passes through sample introduction plate 3 and connect with rotating driver 103, and the 102 both ends solderless wrapped connection of flat-toothed belt is in synchronization
On gear 94 and rotating driver 103, to drive synchromesh gear 94 to rotate.
Wherein, code disc optoelectronic sensor 11 and positioning photoelectric sensor 12, the code-disc are provided on the sample introduction plate 3
Photoelectric sensor 11 is U-shaped photoelectric sensor, and the opposite side of rotation drive device 10 is arranged in, the code disc optoelectronic sensor 11
Cooperate with rotation code-disc 95, for judging the rotational angle of rotating transmission device 9, accurately to control the rotation angle of sample disc,
The positioning photoelectric sensor 12 cooperates with the positioning pin 97 being arranged on end cap 96, for determining rising for rotating transmission device 9
Beginning position is used cooperatively and positions photoelectric sensor 12 and positioning pin by code disc optoelectronic sensor 11 and rotation code-disc 95
97 be used cooperatively, accurately controls the absolute position of sample disc and the angle of relative rotation；82 side of synchronous toothed belt to
It is additionally provided with another positioning photoelectric sensor, for judging the position of sample introduction plate 3, the linear drive motor 81, rotation driving
Motor 101, code disc optoelectronic sensor 11 and two positioning photoelectric sensors 12 respectively with the driving that is arranged in sample introduction back box 4
Control panel 13 connects, and the drive control plate 13 is used to control the rotation of linear drive motor 81 and rotary drive motor 101, and
Read the motion information that code-disc photoelectric sensor 11 and two positioning photoelectric sensors 12 obtain.Wherein drive control plate is for electricity
The scheme of machine driving, including but not limited to common drive and control of electric machine chip TMC2660, L298N etc., the simulation of photoelectric sensor
Output signal transfers to control system to handle after being acquired by analog/digital converter.The drive control plate 13 is mounted as a whole on
In sample introduction back box 4, close to 7 side of Left-side support column.
As shown in figure 11, the swivel bearing 93 includes follower shaft 931, deep groove ball bearing 932, axle sleeve 933 and screw
934 are constituted, wherein the follower shaft 931 passes through the mounting hole in 33 center of recess platform of sample introduction plate 3, two deep groove ball bearings
932 provide the rotation relative to follower shaft 931, and the axle sleeve 933 is interval among two deep groove ball bearings 932, so that three
The height of person is identical as the height of rotation code-disc 95 and synchromesh gear 94, and the internal diameter of two deep groove ball bearings 932 and axle sleeve 933 is equal
It is placed on 931 outer diameter of follower shaft, the screw 934 passes through driving wheel axis 931 and is fixed on sample introduction plate substrate 31.
Wherein, the sample disc button 91 is used to cooperate with 2 bottom close installation of sample disc, may include a variety of design schemes,
For example, being as shown in Figure 9 a boss structure, rounded bottom is equipped with threaded hole corresponding with space disc 92, raised step
Portion is that notch is cylindrical, and 2 bottom of sample disc is set as corresponding concave inward structure；Alternatively, as shown in Figures 12 and 13, or a circle
Dish structure, center are equipped with threaded hole corresponding with space disc 92, and disk border is equipped with notch, for corresponding to sample disc 2 convex
The cooperation of structure out.
As shown in FIG. 14 and 15, the whole cylindrical structure of the sample disc 2, is provided in 2 excircle of sample disc
One several cellular through-holes of circle, the via bottoms gradually taper up the support portion to be formed and be used to support 1 bottom of sample cell, described
The opening of via bottoms is used to support and mentions greater than the sample lift lever 51 that sample cell hoisting mechanism 5 below sample disc 2 is arranged in
The support for rising sample cell 1 promotes end 511, and in lifting process, the support of the sample lift lever 51 promotes end 511 and passes through
Through-hole in sample disc 2, and support 1 bottom of sample cell being placed in through-hole and make its rising, and make 1 upper end opening of sample cell
Portion and 15 bottom of swab are fitted close to form sealing, and the sample cell 1 begins during tight fit moves synchronously with swab 15
Opposing seal state is kept eventually.
Wherein, the sample disc 2 includes the sample disc upper cover 21 to interconnect and sample cell bee slotted disk 22, in institute
It states 21 edge of sample disc upper cover and is provided with several sample pipe through-holes 211, several sample pipe through-holes 211 and sample cell bee slotted disk
Several sample cell bee slots 221 of 22 edges setting are corresponded and are connected to, and are provided with handle in the sample disc upper cover 21
23, the handle 23 uses door handle shape structure, and hand grip portion one end is that tip is indicated for sample cell, the sample cell bee slotted disk
22 bottoms be equipped with groove corresponding with 91 size of sample disc button or projective structure, for rotating mechanism detachable connection,
And it is rotatably assorted with the formation of sample disc button 91.It, can be singlehanded by sample disc in the state of sample disc export by holding handle
It is whole to propose, in order to the replacement of multitube sample cell and loading in sample disc.
As shown in Figure 16,17 and 18, in the present embodiment, sample cell hoisting mechanism 5 and sampling needle 16 and swab 15 cooperate
It using, the sampling needle 16 is fixed on sampling needle rack 17, and the sampling needle rack 17 is fixedly connected with substrate 18,
Swab sliding equipment 19 and sample cell hoisting mechanism 5, the swab 15 and swab sliding equipment are provided on the substrate 18
19 connections, the sample cell 1 are placed on sample cell hoisting mechanism 5, effect of the sample cell hoisting mechanism 5 in driving mechanism
Under be lifted up, in lifting process, 1 upper end opening portion of sample cell and 15 bottom of swab, which are fitted close, to form sealing and will
Swab 15 jacks up, and the sample cell hoisting mechanism 5 and swab sliding equipment 19 move synchronously, and the sample cell hoisting mechanism 5 can
Complete the absorption transfer of sample in sample cell 1, the relative movement of swab 15 and sampling needle 16 and position control and sampling needle 16
The cleaning function of inside and outside wall.
The working principle of the invention is:
Sample introduction stage, various kinds quality control 1(such as 32 blood sampling tube pipes) be placed in sample disc 2 after, by disengaging storehouse driving mechanism drive
Inwardly warehouse entry movement is completed in movement to sample introduction plate 3；The accurate selection of sample cell 1 is completed with rotating mechanism again；And finally by sample
The sample cell 1 is lifted up by quality control hoisting mechanism 5, until sampling needle 16 is inserted into bottom in sample cell 1, draws sample by sampling needle 16
Product simultaneously inject cell analysis pond or flow chamber.
It varies the stage, sample cell hoisting mechanism 5 first separates sample cell 1 with sampling needle 16, and completes in sampling needle 16
The cleaning of outer wall；Sample cell 1 is reset in its original honeycomb through-hole in sample disc again, rotating mechanism 2 will be lower the same
Below the rotation to sampling needle 16 of quality control 1；It is promoted again by sample cell hoisting mechanism 5, sampling needle 16 is sampled.
Export stage, sample cell 1 are completed to reset, and in the honeycomb through-hole in sample disc；Rotating mechanism is by sample
The handle 23 of product disk 2 is rotated to the position of tip inward；It drives sample introduction plate 3 to move out by disengaging storehouse driving mechanism and completes export
Movement, user can perform fighting the upper cover 144 of warehouse shell 14 at this time, sample disc 2 entirely be proposed, and carry out the replacement of sample cell 1.
The independent addressing of high-throughput test tube in the present invention selects, and by rotating stepper motor, code disc optoelectronic sensor and determines
Position photoelectric sensor is completed, and sample disc button, swivel bearing, synchromesh gear and the close fit for rotating code-disc, providing can be axial
Fixed, tangential flexible rotating and component can quick-speed plug cooperation feasibility.The disengaging storehouse of Electronic control sample disc acts, can
Facilitate the whole of sample disc to take out, and builds closed environment.The taking-up of sample disc is that clinical user is brought greatly just
Victory, separate unit instrument can be equipped with multiple sample discs, further save the working efficiency of personnel.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (9)
1. a kind of automatic sample handling system for the detection of sample cell high throughput, including the sample for placing multitube sample cell (1)
Disk (2), the sample disc (2) are arranged on sample introduction plate (3) by rotating mechanism, it is characterised in that: the sample introduction plate (3) passes through
Disengaging storehouse driving mechanism is connect with sample introduction back box (4), and the sample disc (2) being arranged on the sample introduction plate (3) drives in disengaging storehouse
Multitube sample relative to sample introduction back box (4) warehouse entry or export under the action of mechanism, in warehouse entry state, on the sample disc (2)
Quality control (1) carries out promotion suction sample with sample cell hoisting mechanism (5) cooperation respectively can be to the sample disc in export state
(2) the multitube sample cell (1) on is replaced；
The whole cylindrical structure of the sample disc (2), it is several cellular to be provided with a circle in the sample disc (2) excircle
Through-hole, the via bottoms gradually taper up the support portion to be formed and be used to support sample cell (1) bottom, the opening of the via bottoms
Greater than setting, the sample lift lever (51) of sample cell hoisting mechanism (5) is used to support and promotes sample cell below sample disc (2)
(1) support promotes end (511), and in lifting process, the support of the sample lift lever (51) promotes end (511) and passes through
Through-hole in sample disc (2), and support sample cell (1) bottom being placed in through-hole and make its rising, and make on sample cell (1)
End opening portion and swab (15) bottom are fitted close to form sealing, and the swab (15) connect with swab sliding equipment (19), institute
It states sample cell hoisting mechanism (5) and swab sliding equipment (19) moves synchronously, the sample cell (1) is closely being matched with swab (15)
Opposing seal state is remained in contract step motion process.
2. it is according to claim 1 for sample cell high throughput detection automatic sample handling system, it is characterised in that: it is described into
Export driving mechanism includes line slide rail mould group (6), support post (7) and linear drive apparatus (8), the support post
(7) be fixedly connected in sample introduction back box (4), the line slide rail mould group (6) links together with support post (7), it is described into
Template (3) is slidably arranged in line slide rail mould group (6) and connect with linear drive apparatus (8), and the sample introduction plate (3) is straight
The linearly operating of warehouse entry and export is completed under the action of line driving device (8).
3. it is according to claim 2 for sample cell high throughput detection automatic sample handling system, it is characterised in that: it is described into
Template (3) includes the protrusion interconnecting piece (32) of sample introduction plate substrate (31) and bottom, is recessed in the middle part of the sample introduction plate substrate (31)
Sunken platform (33), the prominent interconnecting piece (32) protrude downward from the side wall and and linear drive apparatus of recess platform (33)
(8) it connects, is respectively arranged with the support post of parallel arrangement in recess platform (33) two sides of the sample introduction plate substrate (31)
(7), the line slide rail mould group (6) being arranged on the support post (7) is corresponding with the boss that sample introduction plate substrate (31) two sides are formed
Cooperation, the line slide rail mould group (6) are used for linear slide of the sample introduction plate substrate (31) relative to support post (7).
4. the automatic sample handling system according to claim 3 for the detection of sample cell high throughput, it is characterised in that: described straight
Line driving device (8) includes linear drive motor (81), synchronous toothed belt (82), driving wheel (83) and driven wheel (84), described
Linear drive motor (81) is fixedly connected on support post (7), and the driving wheel (83) is dynamic with linear drive motor (81)
The connection of power output end, the driven wheel (84) are rotatably arranged on support post (7), synchronous toothed belt (82) both ends
On driving wheel (83) and driven wheel (84), the synchronous toothed belt (82) passes through the prominent of connection component and sample introduction plate (3) for solderless wrapped connection
Interconnecting piece (32) connects out, and the sample introduction plate (3) moves synchronously with synchronous toothed belt (82).
5. the automatic sample handling system according to claim 4 for the detection of sample cell high throughput, it is characterised in that: the rotation
Rotation mechanism includes rotating transmission device (9) and rotation drive device (10), the rotating transmission device (9) include from top to bottom according to
Sample disc button (91), space disc (92), swivel bearing (93), synchromesh gear (94), rotation code-disc (95) and the end of secondary arrangement
It covers (96), the sample disc button (91), space disc (92), synchromesh gear (94), rotation code-disc (95) and end cap (96) pass through
Connector is fixed together composition overall structure, the sample disc button (91) and sample disc (2) detachable connection, described
End cap (96) is set to the bottom of rotation code-disc (95), and the synchromesh gear (94) and rotation code-disc (95) are socketed in swivel bearing
(93) it on, and is rotatablely connected by swivel bearing (93) and sample introduction plate (3).
6. the automatic sample handling system according to claim 5 for the detection of sample cell high throughput, it is characterised in that: the rotation
Rotary driving device (10) is fixed on sample introduction plate (3), the lateral position of swivel bearing (93), and the rotation drive device (10) is logical
Crossing rotating transmission device (9) drives sample disc (2) to rotate comprising rotary drive motor (101), flat-toothed belt
(102) and rotating driver (103), the rotary drive motor (101) is fixed on sample introduction plate (3), and the rotation
The power output shaft of driving motor (101) passes through sample introduction plate (3) and connect with rotating driver (103), the flat-toothed belt
(102) both ends solderless wrapped connection is on synchromesh gear (94) and rotating driver (103), to drive synchromesh gear (94) to rotate.
7. the automatic sample handling system according to claim 6 for the detection of sample cell high throughput, it is characterised in that: described
Code disc optoelectronic sensor (11) and positioning photoelectric sensor (12), the code disc optoelectronic sensor are provided on sample introduction plate (3)
(11) cooperate with rotation code-disc (95), for judging the rotational angle of rotating transmission device (9), the positioning photoelectric sensor
(12) cooperate with the positioning pin (97) being arranged on end cap (96), it is described for determining the initial position of rotating transmission device (9)
Synchronous toothed belt (82) is laterally additionally provided with another positioning photoelectric sensor, for judging the position of sample introduction plate (3), the straight line
Driving motor (81), rotary drive motor (101), code disc optoelectronic sensor (11) and two positioning photoelectric sensors (12) point
It is not connect with the drive control plate (13) being arranged in sample introduction back box (4), the drive control plate (13) is for controlling straight line drive
The rotation of dynamic motor (81) and rotary drive motor (101), and read code-disc photoelectric sensor (11) and two positioning photoelectric transfers
The motion information that sensor (12) obtains.
8. the automatic sample handling system according to claim 1 for the detection of sample cell high throughput, it is characterised in that: described
Sample introduction back box (4) periphery is provided with warehouse shell (14), and the warehouse shell (14) includes bottom shell (141), front panel
(142), back shroud (143) and upper cover (144), the planar base of bottom shell (141) installation to sample introduction back box (4)
(41) lower section, the front panel (142) is circular arc facade and internal diameter is greater than sample disc (2) outer diameter, and is installed to sample introduction plate (3)
Front, to the left and right side and the back side of sample introduction back box (4), the upper cover (144) is closed by rotation for back shroud (143) installation
Page installation is to back shroud (143) upper surface, and under sample introduction plate (3) export state, the upper cover (144) is opened up sample in turn
Product disk (2) proposes, under sample introduction plate (3) warehouse entry state, the warehouse shell (14) forms relatively closed environment.
9. the automatic sample handling system according to claim 1 for the detection of sample cell high throughput, it is characterised in that: the sample
Product disk (2) includes the sample disc upper cover (21) to interconnect and sample cell bee slotted disk (22), in the sample disc upper cover
(21) edge is provided with several sample pipe through-holes (211), several sample pipe through-holes (211) and sample cell bee slotted disk (22) side
Several sample cell bee slots (221) of edge setting correspond and are connected to, and are provided with handle on the sample disc upper cover (21)
(23), the sample cell bee slotted disk (22) bottom and rotating mechanism detachable connection.
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| CN107643418B (en) * | 2017-11-14 | 2021-01-26 | 博奥颐和健康科学技术（北京）有限公司 | Positioning system and positioning calibration device thereof |
| CN107748271B (en) * | 2017-11-27 | 2023-06-27 | 桂林优利特医疗电子有限公司 | Single sample feeding device of blood analyzer adapting to different test tubes |
| CN109060641B (en) * | 2018-10-31 | 2024-06-18 | 江苏卓微生物科技有限公司 | Porous sample injection cell counter |
| CN109682765A (en) * | 2018-12-31 | 2019-04-26 | 天津精益宽谱科技有限公司 | A kind of spectroanalysis instrument with automatic replacement sample |
| CN110361493B (en) * | 2019-08-07 | 2024-05-10 | 常州磐宇仪器有限公司 | Multi-position automatic sample injection device |
| WO2021212384A1 (en) * | 2020-04-22 | 2021-10-28 | 深圳华大智造科技股份有限公司 | Sample pretreatment system |
| CN111521547A (en) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | Particle analyzing and sorting device and method |
| CN111883414B (en) * | 2020-07-15 | 2023-02-10 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN113353632B (en) * | 2021-06-28 | 2023-04-07 | 散裂中子源科学中心 | Automatic sample changing mechanism |
| CN116183792B (en) * | 2023-04-25 | 2023-07-04 | 河北普润环境工程有限公司 | Full-automatic thermal desorption device of rim plate material loading formula |
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| CN207133304U (en) * | 2017-08-22 | 2018-03-23 | 重庆博奥新景医学科技有限公司 | A kind of automatic sample handling system for the detection of sample cell high flux |
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| ES8401636A1 (en) * | 1981-07-20 | 1983-12-16 | American Hospital Supply Corp | Loading and transfer assembly for chemical analyzer. |
| JP3803347B2 (en) * | 2004-02-19 | 2006-08-02 | 株式会社アイディエス | Preparative dispensing equipment |
| CN105004873B (en) * | 2015-07-19 | 2017-03-01 | 武汉明德生物科技股份有限公司 | Centrifugal turntable mechanism for full-automatic immune quantitative analyser |
| EP3196648B1 (en) * | 2016-01-22 | 2021-03-31 | Roche Diagniostics GmbH | Device for lifting a sample tube |
| CN106370476B (en) * | 2016-08-31 | 2019-09-24 | 武汉明德生物科技股份有限公司 | Full-automatic immune quantitative analyzer pressure pipe structure and its compression method |
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