CN111855985A - Analysis meter - Google Patents

Analysis meter Download PDF

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Publication number
CN111855985A
CN111855985A CN202010764858.0A CN202010764858A CN111855985A CN 111855985 A CN111855985 A CN 111855985A CN 202010764858 A CN202010764858 A CN 202010764858A CN 111855985 A CN111855985 A CN 111855985A
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detection
reagent
sample
analyzer
reaction
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CN202010764858.0A
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宋世琦
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Individual
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004Cleaning sample transfer devices

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The present invention provides an analyzer comprising: the reagent system comprises a reagent box tray for containing a reagent box and a reagent box, wherein the reagent box is provided with a loading port, and the loading port is used for loading the reagent box; the incubation device is provided with at least one group of reaction container assembly stations, and at least one group of reaction container assemblies are arranged on the reaction container assembly stations in a matched mode; a reaction vessel is contained within the reaction vessel assembly; the detection module is integrated with at least one detection interface matched with the corresponding station of the incubation device, and the detection interface is correspondingly provided with at least one detection module; a loading device comprising a sample arm for extracting a sample to a reaction vessel; a reagent arm for extracting a reagent into the reaction vessel. The analyzer disclosed by the invention is applied to an integrated incubation device, can realize small volume and scientific and compact structure of the whole analyzer, and can improve the detection efficiency under the unit working area.

Description

Analysis meter
Technical Field
The invention relates to the field of medical equipment, in particular to an analysis and detection instrument for a biological sample.
Background
Biological sample analyzers are often used in hospitals for biological detection and analysis of blood, body fluids, and the like.
In the current market, the traditional sample analysis and inspection instrument is one-machine-one, namely, an incubation mechanism is matched with a specified detection module to finish specified detection, and the one-machine-one, namely, the incubation mechanism is matched with the specified detection module to finish specified detection.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a biological sample analyzer. In order to solve at least one of the above technical problems, the present invention provides the following technical solutions: an analyzer, comprising: the sample loading system comprises a sample tray, a test tube for containing a sample and a manipulator for loading, wherein the sample tray is internally provided with the test tube for containing the sample; the reagent system comprises a reagent box tray for containing a reagent box and a reagent bin, wherein the reagent bin is provided with a loading port for loading the reagent box; the incubation device is provided with at least one group of reaction container assembly stations, and at least one group of reaction container assemblies are arranged on the reaction container assembly stations in a matched mode; a reaction vessel is contained within the reaction vessel assembly; the detection module is integrated with at least one detection interface matched with the corresponding station of the incubation device, and the detection interface is correspondingly provided with at least one detection module; a loading device comprising a sample arm for taking and releasing a sample to a reaction vessel; a reagent arm for extracting and releasing reagents into the reaction vessel.
Further, as a preferred optional embodiment of the present invention, a moving device is integrally installed at the matching position of the incubation device, and the moving device moves the reaction container into a detection channel, which is provided near the first detection module and completes the detection.
Further, as a preferred optional embodiment of the present invention, the incubation device is provided with a detection hole or a detection interface for biological detection, and the second detection module detects the reaction solution in the reaction container through the detection hole or the detection interface.
Further, as a preferred optional embodiment of the present invention, the incubation device is provided with other interfaces of the detection module.
Further, as a preferred optional embodiment of the present invention, the incubation device further comprises an incubation cover for performing auxiliary temperature control on the incubation device. The temperature in the incubation device is controlled to be 37 ℃ plus or minus 1 ℃.
Further, as a preferred alternative embodiment of the present invention, the incubation device is in the shape of a loop or a straight line.
Further, as a preferred alternative embodiment of the present invention, the reaction container assembly is provided as a cuvette assembly or/and a reaction cup assembly. The cuvette assembly accommodates at least one cuvette. The reaction cup assembly accommodates and is provided with at least one reaction cup. The first detection module is an immunodetection module. The second detection module is a biochemical detection module.
Further, as a preferred optional embodiment of the present invention, the reagent chamber has a refrigeration function, and the working temperature is 5 degrees plus or minus 5 degrees.
Further, as a preferred optional embodiment of the present invention, the analyzer is provided with a release port for the sample to be detected corresponding to the position of the incubation device. And a reagent release port is arranged at the position of the analyzer corresponding to the incubation device.
Further, as a preferred alternative embodiment of the present invention, the analyzer operating steps include:
a) a reagent loading step: manually placing the reagent box in the reagent box tray, and loading the reagent box into the reagent bin through the loading port after the manipulator grabs the reagent box according to the instruction; and releasing the reagent to the reaction vessel after the reagent is extracted from the kit by the reagent arm;
b) a sample loading step: manually placing a sample to be detected in a sample tray, loading the sample to a sample transmission unit through a manipulator, extracting the sample through a sample arm, and placing the sample in a reaction container;
c) after the steps a) and b) are finished, carrying out incubation reaction in a reaction container;
d) the incubation device rotates to enable the position of the reaction container to be detected to be close to the detection module, the reaction container is moved to the arranged detection channel through the action of the moving device, the detection channel is close to the first detection module, and first detection is completed.
Further, as a preferred alternative embodiment of the present invention, the method further comprises performing a biological detection analysis directly on the reactor in the incubation device through the second detection module. The method further comprises stirring the sample reagent mixture in the reaction vessel after the reagent release is complete. The method also comprises the steps of cleaning and separating the reaction container through the cleaning module after the incubation reaction is finished, and then detecting. The method also comprises the step of cleaning the reaction vessel through the cleaning module after the detection is finished. The method also comprises the step of unloading the used sample and the reagent box by a mechanical arm after the detection is finished.
The invention has the beneficial effects that: the invention is characterized in that the integration of the incubation mechanism and the detection module is the key point, when online is realized, (the online principle is that the arrangement of the sample rack is arranged according to the working radius of the sampling mechanical arm to realize online), so that 'one machine with multiple purposes', namely the incubation mechanism is matched with different detection modules to finish different detections, and the 'online multiple purposes', namely the incubation mechanism is matched with different detection modules to finish different detections, finally, the technical effects of adding different reagents to one sample, combining different detection modules and simultaneously carrying out multiple detections are realized on the integrated machine, and the technical effect of simultaneously detecting a plurality of kits by combining different detection module devices on one sample is formed, so that the integrated biochemical immunoassay all-in-one machine can simultaneously detect a plurality of kits, thereby meeting the requirements of primary.
In addition, the whole machine is small in size, scientific and compact in structure, and the detection efficiency can be improved in unit working area.
In addition, the software sends out a detection system instruction to realize automatic detection, and the automatic link comprises the following steps: extracting samples and reagents; the detection efficiency is improved, and meanwhile, the error rate caused by manual operation is reduced. The machine has high automation efficiency and high detection speed.
Drawings
In order to more clearly explain the technical solutions of the embodiments of the present invention, the drawings required in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and that for a person skilled in the art, other relevant drawings can be obtained from these drawings without inventive effort.
The invention will be explained in detail below with the aid of embodiments which are schematically illustrated in the drawings, in which:
FIG. 1 is a first general structural diagram of the present invention;
FIG. 2 is a schematic view of the overall structure of the present invention;
FIG. 3 is a third schematic view of the overall structure of the present invention;
FIG. 4 is a fourth schematic view of the overall structure of the present invention;
FIG. 5 is a schematic view of the first embodiment of the present invention;
FIG. 6 is a schematic structural view of an incubation apparatus according to the present invention;
FIG. 7 is a fourth schematic view of a portion of the present invention;
FIG. 8 is a schematic view of a portion of the present invention;
FIG. 9 is a first schematic structural view of an incubator of the present invention;
FIG. 10 is a schematic view of the structure of the incubator of the present invention;
FIG. 11 is a schematic view of a portion of the incubator of the present invention;
FIG. 12 is an exploded view of an incubator construction of the present invention;
FIG. 13 is a schematic view of a cuvette structure according to the present invention;
FIG. 14 is a schematic view of a linear structure of the incubation device of the present invention;
description of reference numerals: 1. analyzer, 2, holder, 3, sample tray, 4, test tube, 5, manipulator, 6, kit, 7, kit tray, 8, reagent storehouse, 9, loading port, 10, sample arm, 11, reagent arm, 100, incubation device, 101, heat preservation cover, 102, detection channel, 106, first detection module, 107, third detection module, 103, second detection module, 104, mobile device (ejector pin), 105, cleaning component, 200, incubator, 201, incubation tray, 203, reaction cup station, 204, cuvette station, 202, reaction cup component, 206 cuvette component, 207 cuvette, 208, reaction cup, 205, detection hole or detection interface.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "top", "left", "right", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
In the present invention, unless otherwise specifically stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly and may include, for example, a fixed connection, a detachable connection, or an integral part thereof, either directly or indirectly through intervening media, either internal or external to the two elements or in interactive relation with the two elements. It is obvious to those skilled in the art that the specific meanings of the above terms in the present invention can be understood according to specific situations.
In the present invention, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise direct contact between the first and second features, or may comprise direct contact between the first and second features through another feature not in direct contact. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
The invention will be further described with reference to the accompanying drawings.
A modular bridge of the present invention will now be described in more detail with reference to the accompanying drawings.
As shown in fig. 1 to 4, the present invention provides an analyzer for clinical diagnosis, testing or sample analysis such as clinical chemistry analysis, biochemistry of samples such as blood, serum, plasma, urine, DNA detection, immunological detection, etc.
An analyzer 1 comprising: a bracket 2; the sample loading system comprises a sample tray 3, a test tube 4 for containing a sample and a manipulator 5 for loading, wherein the sample tray 3 contains the test tube 4 for containing the sample; the reagent system comprises a reagent box tray 7 for containing a reagent box 6 and a reagent bin 8, wherein the reagent bin 8 is provided with a loading port 9, and the loading port 9 is used for loading the reagent box 6; the incubation device 100 is provided with at least one group of reaction vessel assembly stations, and at least one group of reaction vessel assemblies 202 and 206 are arranged on the reaction vessel assembly stations in a matching way; reaction vessel assemblies 202, 206 house reaction vessels 207, 208 therein; the detection module is integrated with at least one detection interface in a corresponding station of the incubation device 100, and the detection interface is correspondingly provided with at least one detection module; a loading device comprising a sample arm 10 for taking a sample and releasing it to a reaction vessel; a reagent arm 11 for extracting and releasing reagents into the reaction vessel.
In which, as shown in fig. 5-14, the incubation device 100 and some of the detail matching positions thereof are integrally installed with a moving device, and the moving device acts to move the reaction container 208 into the detection channel 102, the detection channel 102 is close to the first detection module 106, and the detection is completed. The incubation device 100 is provided with a detection hole or a detection interface 205 for biological detection, and the second detection module 103 detects the reaction solution in the reaction container through the detection hole or the detection interface 205.
The incubation device 100 is matched with and reserved with other detection module 107 interfaces. The device also comprises a heat preservation cover 101 which is used for carrying out auxiliary temperature control on the incubation device 100; the temperature in the incubation apparatus 100 was controlled to 37 ℃ plus or minus 1 ℃.
The incubation device 100 is ring-shaped, wherein fig. 1-13 show a ring-shaped embodiment, and fig. 14 shows an example where the incubation device 100 is straight.
The reaction vessel assemblies 206, 202 are provided as either the cuvette assembly 206 or/and the reaction cup assembly 202. The cuvette assembly 206 accommodates the placement of at least one cuvette 207. Reaction cup assembly 202 houses at least one reaction cup 208.
For the examination module, the first detection module is an immunological detection module, and the second detection module is a biochemical detection module. The detection module integrates a biochemical detection analysis module and a luminescence detection analysis module in the embodiment; in addition, other analysis module access ports can be reserved simultaneously according to needs to realize multiple kinds of detection.
The reagent bin 8 has a refrigeration function, and the working temperature is 5 degrees plus or minus 5 degrees. The analyzer 1 is provided with a release port for the sample to be detected at a position corresponding to the incubation device 100. The analyzer 1 is provided with a reagent release port at a position corresponding to the incubation device 100.
In addition, the invention also discloses a working method of the analyzer, and the working steps of the analyzer comprise:
a) a reagent loading step: manually placing the reagent box in a reagent box tray 7, grabbing the reagent box by a manipulator 5 according to an instruction, and loading the reagent box into a reagent bin 8 through a loading port 9; extracting reagent by a reagent arm and placing the reagent in a reaction container;
b) a sample loading step: manually placing a sample to be detected in a sample tray 3, loading the sample to a sample transmission unit through a manipulator 5, extracting the sample through a sample arm, and placing the sample in a reaction container;
c) after the steps a) and b) are finished, carrying out incubation reaction in a reaction container;
d) the incubation device 100 rotates to enable the position of the reaction container 208 to be detected to be close to the detection module, the moving device moves the reaction container 208 to the arranged detection channel 102, the detection channel 102 is close to the first detection module 106, and the first detection is completed.
The method further comprises performing a biological detection analysis directly on the reaction vessel in the incubation device (100) by the second detection module.
The method further comprises stirring the sample reagent mixture in the reaction vessel after the reagent release is complete.
The method also comprises the steps of cleaning and separating the reaction container through the cleaning module after the incubation reaction is finished, and then detecting.
The method also comprises the step of cleaning the reaction vessel through the cleaning module after the detection is finished.
The method also comprises the step of unloading the used sample and the reagent box by a manipulator (5) after the detection is finished.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention. Therefore, the protection scope of the present invention should be determined by the appended claims.

Claims (14)

1. An analyzer (1), characterized in that it comprises: a support (2);
the sample loading system comprises a sample tray (3), test tubes (4) for containing samples are contained in the sample tray (3), and a manipulator (5) for loading;
the reagent system comprises a reagent box tray (7) for containing a reagent box (6) and a reagent bin (8), wherein the reagent bin (8) is provided with a loading port (9), and the loading port (9) is used for loading the reagent box (6);
the incubation device (100) is provided with at least one group of reaction container assembly stations, and at least one group of reaction container assemblies (202, 206) are arranged on the reaction container assembly stations in a matching way; reaction vessels (207, 208) are contained within the reaction vessel assemblies (202, 206);
the detection module is integrated with at least one detection interface in a corresponding station of the incubation device (100), and the detection interface is correspondingly provided with at least one detection module;
a loading device comprising a sample arm (10) for taking a sample and releasing it to a reaction vessel; a reagent arm (11) for extracting and releasing reagents into the reaction vessel.
2. The analyzer (1) according to claim 1, characterized in that: the incubation device (100) is provided with a moving device in a matching position in an integrated mode, the moving device moves the reaction container (208) into the arranged detection channel (102), and the detection channel (102) is close to the first detection module (106) and completes detection.
3. The analyzer (1) according to claim 1, characterized in that: the incubation device (100) is provided with a detection hole or a detection interface (205) for biological detection, and the second detection module (103) detects the reaction liquid in the reaction container through the detection hole or the detection interface (205).
4. The analyzer (1) according to claim 1, characterized in that: the incubation device (100) is matched with and reserved with other detection module (107) interfaces.
5. The analyzer (1) according to claim 1, characterized in that: the incubation device (100) further comprises a heat preservation cover (101) for performing auxiliary temperature control on the incubation device (100), wherein the control temperature in the incubation device (100) is 37 degrees plus or minus 1 degree.
6. The analyzer (1) according to claim 1, characterized in that: the incubation device (100) is annular or linear.
7. The analyzer (1) according to claim 1, characterized in that: the reaction container assembly (206, 202) is provided as a cuvette assembly (206) or/and a reaction cup assembly (202); the cuvette assembly (206) accommodates at least one cuvette (207); the reaction cup assembly (202) accommodates at least one reaction cup (208).
8. The analyzer (1) according to claim 1, characterized in that: the first detection module is an immunodetection module; the second detection module is a biochemical detection module.
9. The analyzer (1) according to claim 1, characterized in that: the reagent bin (8) has a refrigeration function, and the working temperature is 5 degrees plus or minus 5 degrees.
10. The analyzer (1) according to claim 1, characterized in that: a release port for a sample to be detected is arranged at the position of the analyzer (1) corresponding to the incubation device (100); and a reagent release port is arranged at the position of the analyzer (1) corresponding to the incubation device (100).
11. The method of operating an analyzer as set forth in claims 1-10, wherein the analyzer operating step includes:
a) a reagent loading step: manually placing the reagent box in a reagent box tray (7), and loading the reagent box into a reagent bin (8) through a loading port (9) after a manipulator (5) grabs the reagent box according to an instruction; the reagent is released into the reaction container after being extracted from the kit through the reagent arm;
b) a sample loading step: manually placing a sample to be detected in a sample tray (3), loading the sample to a sample transmission unit through a manipulator (5), extracting the sample through a sample arm and placing the sample in a reaction container;
c) after the steps a) and b) are finished, carrying out incubation reaction in a reaction container;
d) the incubation device (100) rotates to enable the position of the reaction container (208) to be detected to be close to the detection module, the moving device moves the reaction container (208) into the arranged detection channel (102), the detection channel (102) is close to the first detection module (106), and the first detection is completed.
12. Working method according to claim 11, characterized in that it further comprises carrying out a biological detection analysis directly on the reaction vessels in the incubation device (100) by means of a second detection module; the method further comprises stirring the sample reagent mixture in the reaction vessel after the reagent release is complete.
13. The working method of claim 11, further comprising cleaning and separating the reaction vessel by a cleaning module after the incubation reaction is finished, and then detecting; the method also comprises the step of cleaning the reaction vessel through the cleaning module after the detection is finished.
14. Working method according to claim 11, characterized in that it further comprises unloading the used samples and cartridges by means of a robot arm (5) after the end of the test.
CN202010764858.0A 2020-08-03 2020-08-03 Analysis meter Pending CN111855985A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112415187A (en) * 2020-11-26 2021-02-26 南京国科医工科技发展有限公司 Homogeneous phase immunoassay appearance
CN113495166A (en) * 2021-06-22 2021-10-12 迪瑞医疗科技股份有限公司 Automatic kit loading system and control method thereof
CN114295850A (en) * 2021-12-31 2022-04-08 沈阳医陆生物科技有限公司 Sample detection system, sample detection method and kit preparation method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112415187A (en) * 2020-11-26 2021-02-26 南京国科医工科技发展有限公司 Homogeneous phase immunoassay appearance
CN113495166A (en) * 2021-06-22 2021-10-12 迪瑞医疗科技股份有限公司 Automatic kit loading system and control method thereof
CN113495166B (en) * 2021-06-22 2024-05-03 迪瑞医疗科技股份有限公司 Automatic loading system for kit and control method thereof
CN114295850A (en) * 2021-12-31 2022-04-08 沈阳医陆生物科技有限公司 Sample detection system, sample detection method and kit preparation method

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Application publication date: 20201030