CN117269468A - Blood detection device and method - Google Patents
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Abstract
The invention discloses a blood detection device and a blood detection method, which belong to the technical field of medical detection, wherein a Z-axis sliding rail is arranged on a workbench, an X-axis sliding rail is arranged above the Z-axis sliding rail, a Y-axis sliding rail is arranged on the X-axis sliding rail, a plurality of mechanical arms sharing a Y axis are arranged on the Y-axis sliding rail, and the mechanical arms are slidably arranged on the Y-axis sliding rail; the chromatographic reagent strip storage area, the biochemical reagent disc storage area, the reagent disc unpacking and packaging module, the reagent strip unpacking and packaging module, the chromatographic incubation area, the reagent disc sample adding area, the biochemical detection module, the immunochromatography detection module, the blood routine detection module, the reagent site, the sample site and the needle washing platform are all arranged on the surface of the workbench; the waste collection box is arranged below the workbench; the pipetting mechanism and the transferring mechanism are respectively arranged on different mechanical arms, the pipetting mechanism comprises a puncture sample adding needle, a pipeline, a diaphragm pump and an electromagnetic valve, and the transferring mechanism comprises a vacuum pump, a sucker, an electromagnetic valve, an air circuit and a rotary motion mechanism. The integration degree of the blood detection device is improved.
Description
Technical Field
The invention belongs to the technical field of medical detection, and particularly relates to a blood detection device and method.
Background
In full-cycle medical decisions such as disease diagnosis, early diagnosis, medication guidance, prognosis judgment, curative effect monitoring, disease prediction and early warning, 70% -80% of data are derived from test medicine. The collection of human samples (blood, body fluids, tissues, etc.) for testing is a major way to obtain clinical diagnostic information. Blood sampling assays are the first and most important examination methods because blood contains a large amount of information about the health of the body. Blood detection is classified into three basic categories of biochemistry, immunity and blood routine according to the detection principle and method.
The principle and technical means of the detection of different types are different, and the matched reagents are different. The current common solution in the industry is that each methodology corresponds to a detection instrument, such as a biochemical analyzer for biochemical detection, an immunoassay analyzer for immunological detection, a hemocytometer for blood routine detection, etc. Although blood tests are performed, each methodology requires different pretreatment of blood, and some require serum or plasma, so that collected blood is treated, and some possibly anticoagulated whole blood is available, but anticoagulated whole blood has different anticoagulants and requires different blood collection tubes. Biochemical assays typically require the use of serum or plasma; blood routine tests require EDTA-K2 to anticoagulate whole blood, and immunological tests are typically performed with serum or plasma, or whole blood.
For a general examination department or an examination institution, a plurality of types of instruments can be provided, blood is collected by blood collecting tubes of different types and is subjected to corresponding pretreatment according to different methodologies and requirements of detection projects, and then the blood is operated on different types of equipment to obtain final clinical diagnosis information. The method is suitable for application scenes with a certain sample size, sufficient sites and complete equipment of operators. However, for basic medical institutions, because the sites are limited, a plurality of types of instruments occupy a large space, sample pretreatment operation is complex, detection quality is easily affected due to improper operation, basic operators lack, meanwhile, operation and maintenance of a plurality of types of equipment are difficult, because of few samples, the quantity of detection distributed on each type of instrument is small, the utilization rate is low, multiple blood tubes are collected, the quantity of actually used blood is small, and blood waste is caused.
In summary, the existing blood detection needs more blood samples for pretreatment and separation detection, the detection process is complex, the requirements on the skills of basic level operators are high, and the detection of different projects needs to be separately carried out by an independent detection device, so that the existing blood detection needs larger equipment arrangement space, is difficult to maintain and is not suitable for basic level medical institutions.
Disclosure of Invention
The embodiment of the invention aims to provide a blood detection device and a blood detection method, which can solve the technical problems that in the prior art, more blood samples are required for pretreatment and separation detection in blood detection, the detection process is complex, the requirements on the skills of basic-level operators are high, and the detection devices are required to be separated for detection of different projects, larger equipment arrangement space is required, and the maintenance is difficult, so that the blood detection device and the blood detection method are not suitable for basic-level medical institutions.
In order to solve the technical problems, an implementation manner of the invention is to provide a blood detection device and a blood detection method.
First aspect
An embodiment of the present invention provides a blood test apparatus including: the device comprises a chromatographic reagent strip storage area, a biochemical reagent disc storage area, a reagent disc unpacking and packaging module, a biochemical detection module, a reagent disc sample adding area, a transfer mechanism, an immunochromatography detection module, a chromatographic incubation area, a pipetting mechanism, a blood routine detection module, a sample position, a reagent position, a needle washing table, a reagent strip unpacking and packaging module, a waste collection box and a workbench;
the workbench is provided with a Z-axis sliding rail, an X-axis sliding rail is arranged above the Z-axis sliding rail, a Y-axis sliding rail is arranged on the X-axis sliding rail, a plurality of mechanical arms sharing the Y axis are arranged on the Y-axis sliding rail, and the mechanical arms are slidably arranged on the Y-axis sliding rail;
the chromatographic reagent strip storage area, the biochemical reagent disc storage area, the reagent disc unpacking and packaging module, the reagent strip unpacking and packaging module, the chromatographic incubation area, the reagent disc sample adding area, the biochemical detection module, the immunochromatography detection module, the blood routine detection module, the reagent site, the sample site and the needle washing platform are all arranged on the surface of the workbench, and the sample site is used for placing a blood sample and a dilution tube;
the waste collection box is arranged below the workbench;
the transfer mechanism comprises a vacuum pump, a sucker, an electromagnetic valve, a gas circuit and a rotary motion mechanism, and the rotary motion mechanism can perform rotary motion perpendicular to a Y axis;
the pipetting mechanism and the transfer mechanism are used for orderly operating surface equipment of the workbench to finish blood detection.
Second aspect
The embodiment of the invention provides a blood detection method, which comprises the following steps:
s101: connecting the blood detection device with a programmable computer, and initializing the blood detection device;
s102: collecting a blood sample of a patient by using a blood collection tube with an anticoagulant, and placing the blood sample and a reagent tube at a sample position;
s103: setting information of a blood sample in a programmable computer, selecting a detection item and setting an operation parameter;
s104: controlling the blood detection device according to the operation parameters, and detecting a blood sample;
s105: generating a report form from the detection result;
s106: and cleaning medical waste, and ending the detection of the blood sample.
In the embodiment of the invention, the manual operation of a user is simplified by arranging the unpacking module, and more importantly, the unpacking module must be used within a certain time after unpacking due to the requirement of the reagent, so that the accuracy of the inspection structure is ensured by the mode of the current unpacking. Through setting up transfer mechanism and pipetting mechanism with multiaxis degree of freedom and remove and pipetting to blood sample and the check out test set that gather, alleviate operating personnel burden, set up biochemical detection module, immunochromatography detection module and blood routine detection module and carry out the classified detection based on impedance method and chemical method to the blood sample whole blood that utilizes the heparin tube that has anticoagulation to gather, need not do sample preliminary treatment, just can accomplish basic unit medical institution blood related detection project, improve blood and detect degree of automation, integrated blood detection device has released medical equipment and has arranged the space, improve equipment utilization, operation and maintenance are simpler, be fit for the application scenario of basic unit, improve blood detection degree of automation, reduce the sample pollution probability that manual detection probably leads to. The single-tube anticoagulation whole blood can realize blood detection of multiple categories, reduce the number of blood collection tubes and the blood collection amount, simplify the sample pretreatment flow and avoid blood waste.
Drawings
Fig. 1 is a schematic structural diagram of a blood testing device according to an embodiment of the present invention.
Fig. 2 is a schematic flow chart of a blood detection method according to an embodiment of the present invention.
The achievement of the object, functional features and advantages of the present invention will be further described with reference to the embodiments, referring to the accompanying drawings.
The reference numerals are explained as follows:
1. a chromatographic reagent strip storage area; 2. a biochemical reagent disk storage area; 3. the reagent tray unpacking module; 4. a biochemical detection module; 5. a reagent tray sample adding area; 6. a transfer mechanism; 7. an immunochromatography detection module; 8. chromatographic incubation zones; 9. a pipetting mechanism; 10. a blood routine detection module; 11. sample position; 12. a reagent site; 13. a needle washing table; 14. the reagent strip unpacking module; 15. a waste collection box; 16. a work table; 161. a Z-axis sliding rail; 162. an X-axis sliding rail; 163. and a Y-axis sliding rail.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The blood detection device and the blood detection method provided by the embodiment of the invention are described in detail below through specific embodiments and application scenes thereof with reference to the accompanying drawings.
Example 1
Referring to fig. 1, a schematic structural diagram of a blood test apparatus according to an embodiment of the present invention is shown.
The embodiment of the invention provides a blood detection device, which comprises: the device comprises a chromatographic reagent strip storage area 1, a biochemical reagent disc storage area 2, a reagent disc unpacking and packaging module 3, a biochemical detection module 4, a reagent disc sample adding area 5, a transfer mechanism 6, an immunochromatography detection module 7, a chromatographic incubation area 8, a pipetting mechanism 9, a blood routine detection module 10, a sample position 11, a reagent position 12, a needle washing table 13, a reagent strip unpacking and packaging module 14, a waste collection box 15 and a workbench 16.
The chromatographic reagent strip storage area 1 stores chromatographic reagent strips, which may contain chemical substances or antibodies for specific biochemical or immunological detection. The biochemical reagent disk storage area 2 is used for storing biochemical reagent disks, and contains chemical reagents for biochemical detection. The reagent disk unpacking module 3 is used for opening and preparing the biochemical reagent disk for subsequent biochemical detection. The biochemical detection module 4 is used for performing biochemical detection, and uses biochemical reagents to analyze biochemical markers in a sample, such as glucose, liver function index, kidney function index, and the like. The reagent disk loading zone 5 is used for mixing the sample with biochemical reagents for biochemical detection. The transfer mechanism 6 is used to transfer a sample or reagent from one area to another for subsequent processing or analysis. The immunochromatography detection module 7 is used for performing immunochromatography detection, and uses an immunoreagent to detect a specific antibody or antigen in a sample, wherein the detection items include inflammation, infectious disease, tumor markers, thyroid gland, sex hormone and the like. The chromatographic incubation zone 8 is used to control the temperature and ensure a stable reaction temperature during immunochromatographic detection or biochemical detection. The pipetting mechanism 9 is used to accurately move and dispense liquids for proper handling of samples and reagents in the various steps. The blood routine detection module 10 is used to perform blood routine detection including red blood cell count, white blood cell count, platelet count, hemoglobin measurement, and the like. Sample station 11 and reagent station 12 are used to house samples and reagents for various assays. The wash station 13 is used to clean and prepare the needle or other liquid handling equipment for analysis. The reagent strip unpacking module 14 is used to open and prepare the chromatographic reagent strip for subsequent chromatographic detection. The waste collection cassette 15 is used to collect and store waste, such as used reagents, sample residues, etc. The work bench 16 is used for providing a space for arranging equipment, integrating various equipment into the work bench 16, reducing the space occupied by equipment arrangement, and also providing an operating space for equipment operation and sample processing.
By arranging the unpacking module, not only is the manual operation of a user simplified, but also the reagent is required to be used in a certain time after unpacking, and the accuracy of the inspection structure is ensured by the mode of the current unpacking.
Through the collaborative work of these modules, make equipment can carry out multiple type blood and detect, including biochemistry, immunity and blood routine detection, through automatic and integrated mode, can improve efficiency and the accuracy of detecting, reduced operating personnel's work load simultaneously.
The workbench 16 is provided with a Z-axis sliding rail 161, an X-axis sliding rail 162 is arranged above the Z-axis sliding rail 161, a Y-axis sliding rail 163 is arranged on the X-axis sliding rail 162, a plurality of mechanical arms sharing the Y axis are arranged on the Y-axis sliding rail 163, and the mechanical arms are slidably arranged on the Y-axis sliding rail 163.
Specifically, the Z-axis is parallel to the table 16 for controlling the forward and backward movement of the transfer mechanism 6 and the pipetting mechanism 9 in the horizontal direction, which enables the transfer mechanism 6 and the pipetting mechanism 9 to adjust the forward and backward directions to accommodate operation, sampling or detection tasks at different positions. The X-axis represents a horizontal side-to-side direction, so the X-axis slide 162 functions to control the side-to-side movement of the stage 16 in the horizontal direction, which enables horizontal positional adjustment of the stage 16 between the sample and the reagent. Y-axis slide rail 163 and robotic arm: the Y-axis slide rail 163 is disposed on the X-axis slide rail 162 and is provided with a plurality of Y-axis-sharing robot arms that can slide in the Y-axis direction to perform adjustment in the height direction, and the robot arms function to move various operation tools, samples, reagents or other devices to designated positions to perform various tasks such as sample processing, reagent loading, analysis, etc.
It will be appreciated that the design of the multi-axis slide and robotic arm allows for highly accurate positional and motion control of the device in multiple directions, such flexibility enabling the device to perform complex operations to accommodate the position and size of different sample and reagent containers. The robotic arms may be programmed to perform various tasks to achieve automated operation, which may reduce human error due to their accuracy and programmability, improving experimental accuracy and repeatability. The design of the multi-axis slide rail and the mechanical arm enables the device to adapt to different types of experiments and detection tasks, including sample processing, reagent sample adding, incubation, detection and the like, and the device has more versatility due to the adaptability. The automatic operation and the multi-axis movement can improve the efficiency of laboratory work, reduce the requirement of manual operation, save time and manpower resources, realize highly accurate sample processing and analysis, and improve the efficiency and quality of laboratory work.
The chromatographic reagent strip storage area 1, the biochemical reagent disk storage area 2, the reagent disk unpacking module 3, the reagent disk unpacking module 14, the chromatographic incubation area 8, the reagent disk sample adding area 5, the biochemical detection module, the immunochromatography detection module 7, the blood routine detection module 10, the reagent site 12, the sample site 11 and the needle washing table 13 are all arranged on the surface of the workbench 16, and the sample site 11 is used for placing a blood sample and a dilution tube.
It will be appreciated that the provision of such devices on the surface of the table 16 makes them very accessible and operable by an operator who can directly contact and manage the sample, reagents and devices without the need for complex mechanical means or highly specific locations to ensure that the blood testing device is able to perform a variety of tasks efficiently and accurately while maintaining operator convenience and device reliability.
The waste collection cassette 15 is disposed below the table 16.
It should be noted that, the waste collection box 15 is disposed below the workbench 16, and uses gravity to collect medical waste, so as to improve the automation degree and resource consumption of the blood detection device, and collect the waste without the operation of staff, so as to protect the integrity of operators and samples, which is helpful for maintaining the sanitation and safety standard of the laboratory.
The pipetting mechanism 9 and the transferring mechanism 6 are respectively arranged on different mechanical arms, the pipetting mechanism 9 comprises a puncture sample adding needle, a pipeline, a diaphragm pump and an electromagnetic valve, the transferring mechanism 6 comprises a vacuum pump, a sucker, the electromagnetic valve, an air circuit and a rotary motion mechanism, and the rotary motion mechanism can perform rotary motion perpendicular to the Y axis.
The pipetting mechanism 9 and the transfer mechanism 6 are used for orderly operating the surface equipment of the workbench 16 to complete blood detection.
The puncture needle is a sharp needle for penetrating the sample or the reagent container and sucking or discharging the liquid. The pipeline is used for conveying liquid and conveying the liquid from one place to another place. Diaphragm pumps are used to generate motive force for pipetting or draining liquid by pumping the diaphragm to create a pressure differential that pushes the liquid to move. The solenoid valve is used for controlling the flow of liquid, can open or close the liquid channel, and is also used for controlling the gas circuit to adjust the operation of the vacuum pump. The vacuum pump is used to create a negative pressure so that objects (e.g., sample containers) can be sucked or grasped. Suction cups are devices used in conjunction with vacuum pumps to suction and hold objects. The gas circuit is used to deliver gas, typically in conjunction with a vacuum pump and solenoid valve. The rotary motion mechanism is a device that can rotate perpendicular to the Y axis for changing the direction of the suction cup to grasp or release objects in different directions.
In practice, by automatically handling the liquid and moving the sample or reagent in order to perform the different steps of the blood test, the pipetting mechanism 9 can be used to mix the sample with the reagent and dispense the liquid into the different test devices, while the transfer mechanism 6 can be used to move the sample container or other devices to complete the test procedure, and the automated operation of these mechanisms helps to improve the efficiency and accuracy of the test while reducing the workload of the operator.
In one possible embodiment, the blood biopsy module includes a WBC count cell and a RBC count cell.
Among them, WBC and RBC cells are key components for performing routine blood tests, mainly for calculating white blood cell count (WBC, white blood cell) and red blood cell count (RBC, red blood cell), which are important clinical tests for assessing the blood health of patients.
In the embodiment of the invention, the manual operation of a user is simplified by arranging the unpacking module, and more importantly, the unpacking module must be used within a certain time after unpacking due to the requirement of the reagent, so that the accuracy of the inspection structure is ensured by the mode of the current unpacking. Through setting up transfer mechanism 6 and pipetting mechanism 9 that have multiaxis degree of freedom remove and pipetting to blood sample and the check out test set that gather, alleviate operating personnel burden, set up biochemical detection module 4, immunochromatography detection module 7 and blood routine detection module 10 and carry out the categorised detection based on impedance method and chemical method to the blood sample whole blood that utilizes the heparin tube that has anticoagulation, need not do sample preliminary treatment, just can accomplish basic unit medical institution blood related detection project, improve blood and detect degree of automation, integrated blood detection device has released medical equipment and has arranged the space, improve equipment utilization, operation and maintenance are simpler, be fit for the application scenario of basic unit, improve blood detection degree of automation, reduce the sample pollution probability that manual detection probably leads to. The single-tube anticoagulation whole blood can realize blood detection of multiple categories, reduce the number of blood collection tubes and the blood collection amount, simplify the sample pretreatment flow and avoid blood waste.
Example two
Referring to fig. 2, a schematic flow chart of a blood detection method according to an embodiment of the present invention is shown.
The blood detection method provided by the embodiment of the invention is applied to a blood detection device.
The blood detection method comprises the following steps:
s101: the blood test apparatus is connected to a programmable computer, and the blood test apparatus is initialized.
In which a programmable computer is a computer system having the ability to process and store data and perform various tasks according to predetermined programs or instructions, the programmable computer is used to control and manage the operation of the blood test apparatus, and to process and analyze data collected from the device, which may be a general desktop computer or an embedded computer. The initialization ensures that the device is operating properly and can perform the detection tasks according to a predetermined procedure to provide accurate detection results.
In one possible implementation, S101 specifically includes:
s1011: loading reagent at a reagent position 12, and loading consumable materials with packages in a chromatographic reagent strip storage area 1 and a biochemical reagent disk storage area 2, wherein the consumable materials comprise a chromatographic reagent strip and a biochemical reagent disk;
s1012: resetting the mechanical arm.
In particular, initialization refers to a series of preparation operations performed before starting to use the device. Mainly comprising configuring various parameters, settings and options of the device to suit the current detection task. Ensuring that the various components and parts of the device are in normal operation. And ensures that a communication connection is established between the programmable computer and the device for data transmission and control. In addition, the device performs a self-test to ensure that all sensors, instruments and components are functioning properly without failure or abnormality. Calibration of the device may be required to ensure the accuracy of its measurement results. The reagents, consumables and other equipment resources required are prepared for testing. A detection program or software is loaded or started to ensure that the device is able to perform the required detection operations.
S102: a blood sample of a patient is collected using a blood collection tube with an anticoagulant and a blood sample and a reagent tube are placed at sample site 11.
In one possible embodiment, the anticoagulant is EDTA-K2 (dipotassium ethylenediamine tetraacetate) anticoagulant or hirudin anticoagulant, and the anticoagulant includes that the blood sample is peripheral blood or venous blood.
Specifically, a blood collection tube containing EDTA-K2 anticoagulant is used for collecting 2-3 mL of single-tube venous whole blood or peripheral blood, and the single-tube venous whole blood or peripheral blood is distributed to three detection modules. The dry biochemical technology adopts a microfluidic reagent disk, serum is separated by centrifugation, and the separated serum can be used for subsequent biochemical project detection. The traditional dry biochemical quick detection method uses heparin lithium anticoagulant, and because EDTA-K2 has influence on the biochemical project detection of ionic species, the object-oriented basic medical service is considered, the ionic biochemical detection mainly aims at emergency treatment, and the EDTA-K2 anticoagulant can be used in a device aiming at basic medical detection. Blood routine blood samples require the use of EDTA-K2 anticoagulants, just as desired. The immunochromatography reagent has lower requirements on an anticoagulant, but has requirements on the type of blood sample, red blood cells in whole blood have direct influence on detection, and when the immunochromatography is applied to design, the red blood cells are filtered out by adding a blood filtering membrane, so that plasma participates in subsequent immunoassay.
S103: information of the blood sample is set in a programmable computer, a test item is selected and an operating parameter is set.
In the step of setting the information of the blood sample, the operator or the medical professional needs to provide information about the blood sample, which includes: patient identity information: such as name, age, gender, etc. Sample acquisition time: the date and time of blood sample collection was recorded. Sample source: indicating whether the blood sample is venous blood or peripheral blood from a patient, etc. Patient history: medical history information related to the current health condition may be included to help interpret the test results. In the step of selecting test items, the operator needs to select a specific test item to be performed from a list of available test items, and the different test items include blood routine, biochemical test, immunochromatographic test, etc., and the specific selection depends on the medical requirements and the condition of the patient. In the step of setting the operating parameters, once the test item to be performed is selected, the relevant operating parameters are then set to ensure that the device is operating in the intended manner when performing the test. These parameters include the detection method: for the selected detection item, an appropriate detection method or protocol is selected. Reagent and consumable: the reagents, consumables and detection tools to be used are specified. Analysis conditions: analysis conditions such as temperature, time, etc. are set to ensure that accurate detection results are obtained. Reporting format: the report format that generates the detection result is selected, and may include digital data, graphics, charts, and the like.
It will be appreciated that the necessary configuration of the blood test apparatus to perform accurate testing based on the patient's blood sample information and medical requirements ensures that the device is able to perform the testing tasks according to predetermined criteria and produce reliable test results that facilitate the proper diagnosis and treatment decisions by the medical professionals.
S104: the blood detection device is controlled according to the operation parameters, and the blood sample is detected.
In one possible implementation, S104 specifically includes:
s1041: consumable materials are taken out through the transfer mechanism 6 and placed in the corresponding reagent disk unpacking module 3 or reagent strip unpacking module 14 for unpacking.
S1042: the unpacked consumables are transferred to the chromatographic incubation zone 8 or the reagent tray loading zone 5.
S1043: the reagent and blood sample in the reagent tube are dispensed by the pipetting mechanism 9.
In one possible implementation, S1043 specifically includes:
S1043A: drawing a blood sample from a sample site 11 by a pipetting mechanism 9, adding the blood sample to a biochemical reagent disk, a chromatographic reagent strip and a WBC counting cell of a blood routine detection module 10;
S1043B: diluting the blood sample in the WBC counting cell, and adding the diluted blood sample into the RBC counting cell of the blood routine detection module 10;
S1043C: the puncture sample injection needle of the pipetting mechanism 9 is moved to a needle washing table 13, and the inside, the outside and the pipelines of the puncture sample injection needle are washed;
S1043D: adding the reagent in the reagent tube to the chromatographic reagent strip;
S1043E: and (5) washing the puncture sample adding needle to finish the distribution of the reagent and the blood sample.
S1044: the dispensed blood sample is detected by the biochemical detection module 4, the immunochromatographic detection module 7 and the blood routine detection module 10.
In one possible implementation, S1044 specifically includes:
S1044A: collecting blood routine detection results through the blood routine detection module 10 for novel blood cell count, white blood cell classification and hemoglobin concentration measurement of the blood sample;
S1044B: transferring the biochemical reagent disk to a biochemical detection module 4 for detection through a transfer mechanism 6, diluting a blood sample in the biochemical reagent disk by the biochemical detection module 4, centrifugally separating the diluted blood sample to obtain serum, detecting the serum, and collecting a biochemical detection result;
S1044C: and (3) incubating the chromatographic reagent strip for a preset period of time at room temperature, transferring the incubated chromatographic reagent strip to an immunochromatography detection module 7 for detection through a transfer mechanism 6, obtaining a fluorescence signal value of the chromatographic reagent strip, and obtaining an immunochromatography detection result.
It should be noted that, the accurate results of various blood detection parameters can be obtained through the detection of the three detection modules. Each step is performed in accordance with previously set operating parameters and test items to ensure the reliability and accuracy of the overall test procedure, the test results will be used to assist medical professionals in making diagnostic and therapeutic decisions.
In one possible implementation, S104 further includes:
s1045: inputting the blood routine detection result, the biochemical detection result and the immunochromatography detection result into a programmable computer.
It should be noted that integrating the data of the different modules into one comprehensive result provides a medical professional with more comprehensive blood test information, which is helpful for making more accurate diagnosis and treatment decisions, and the programmable computer can further process the data to generate detailed test reports so that the doctor can better understand the health condition of the patient. This integrated approach helps to improve the accuracy and efficiency of the diagnosis.
S105: and generating a report form according to the detection result.
The report results comprise detected text results and graphic results.
In one possible embodiment, the blood detection method further comprises:
S105A: the report is transmitted to a laboratory information management system.
Wherein the laboratory information management system is a computer system for storing, managing and sharing the test data. This system may be part of the information technology infrastructure of a hospital or laboratory for recording and tracking patient test information.
It should be noted that, the generated report is transmitted to the laboratory information management system for data storage and sharing, and stored in the database for the medical professional to access at any time, so that doctors, nurses and other medical workers with access rights can check and interpret the detection results of the patient to make diagnosis, treatment and monitoring decisions. By integrating the test results into the medical information system, so that a medical team can more conveniently access and utilize the data to provide comprehensive medical care for the patient, while also helping to ensure the accuracy and integrity of the test data, facilitating health management and medical decision-making for the patient.
S106: and cleaning medical waste, and ending the detection of the blood sample.
It will be appreciated that in performing blood tests, medical waste products such as used reagents, blood sample residues, disposable lancets, etc. may contain potentially biohazardous materials and therefore require special disposal to ensure safety and hygiene. The integration degree and the automation degree of the blood detection device are improved, medical staff are prevented from directly contacting medical waste, and the blood detection environment is optimized.
In the embodiment of the invention, the manual operation of a user is simplified by arranging the unpacking module, and more importantly, the unpacking module must be used within a certain time after unpacking due to the requirement of the reagent, so that the accuracy of the inspection structure is ensured by the mode of the current unpacking. Through setting up transfer mechanism 6 and pipetting mechanism 9 that have multiaxis degree of freedom remove and pipetting to blood sample and the check out test set that gather, alleviate operating personnel burden, set up biochemical detection module 4, immunochromatography detection module 7 and blood routine detection module 10 and carry out the categorised detection based on impedance method and chemical method to the blood sample whole blood that utilizes the heparin tube that has anticoagulation, need not do sample preliminary treatment, just can accomplish basic unit medical institution blood related detection project, improve blood and detect degree of automation, integrated blood detection device has released medical equipment and has arranged the space, improve equipment utilization, operation and maintenance are simpler, be fit for the application scenario of basic unit, improve blood detection degree of automation, reduce the sample pollution probability that manual detection probably leads to. The single-tube anticoagulation whole blood can realize blood detection of multiple categories, reduce the number of blood collection tubes and the blood collection amount, simplify the sample pretreatment flow and avoid blood waste.
The foregoing is merely exemplary of the present invention and is not intended to limit the present invention. Various modifications and variations of the present invention will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the invention are to be included in the scope of the claims of the present invention.
Claims (10)
1. A blood test apparatus, comprising: the device comprises a chromatographic reagent strip storage area, a biochemical reagent disc storage area, a reagent disc unpacking and packaging module, a biochemical detection module, a reagent disc sample adding area, a transfer mechanism, an immunochromatography detection module, a chromatographic incubation area, a pipetting mechanism, a blood routine detection module, a sample position, a reagent position, a needle washing table, a reagent strip unpacking and packaging module, a waste collection box and a workbench;
the workbench is provided with a Z-axis sliding rail, an X-axis sliding rail is arranged above the Z-axis sliding rail, a Y-axis sliding rail is arranged on the X-axis sliding rail, a plurality of mechanical arms sharing a Y axis are arranged on the Y-axis sliding rail, and the mechanical arms are slidably arranged on the Y-axis sliding rail;
the chromatographic reagent strip storage area, the biochemical reagent disc storage area, the reagent disc unpacking module, the reagent strip unpacking module, the chromatographic incubation area, the reagent disc sample adding area, the biochemical detection module, the immunochromatography detection module, the blood routine detection module, the reagent site, the sample site and the needle washing table are all arranged on the surface of the workbench, and the sample site is used for placing a blood sample and a dilution tube;
the waste collection box is arranged below the workbench;
the transfer mechanism and the transfer mechanism are respectively arranged on different mechanical arms, the transfer mechanism comprises a puncture sample adding needle, a pipeline, a diaphragm pump and an electromagnetic valve, the transfer mechanism comprises a vacuum pump, a sucker, an electromagnetic valve, an air circuit and a rotary motion mechanism, and the rotary motion mechanism can perform rotary motion perpendicular to a Y axis;
the pipetting mechanism and the transfer mechanism are used for orderly operating the surface equipment of the workbench to finish blood detection.
2. The blood testing device of claim 1, wherein the blood routine testing module comprises a WBC count cell and a RBC count cell.
3. A blood test method, characterized by being applied to the blood test apparatus according to any one of claims 1 to 2, the method comprising:
s101: connecting the blood detection device with a programmable computer, and initializing the blood detection device;
s102: collecting a patient blood sample using a blood collection tube with an anticoagulant and placing the blood sample and a reagent tube at the sample site;
s103: setting information of the blood sample in the programmable computer, selecting a detection item and setting an operation parameter;
s104: controlling the blood detection device according to the operation parameters, and detecting the blood sample;
s105: generating a report form from the detection result;
s106: and cleaning medical waste, and ending the detection of the blood sample.
4. The method for detecting blood according to claim 3, wherein S101 specifically comprises:
s1011: loading reagents in the reagent positions, and loading packaged consumable materials in the chromatographic reagent strip storage area and the biochemical reagent disk storage area, wherein the consumable materials comprise a chromatographic reagent strip and a biochemical reagent disk;
s1012: resetting the mechanical arm.
5. A blood test method according to claim 3, wherein the anticoagulant is EDTA-K2 anticoagulant or hirudin anticoagulant, and the anticoagulant comprises that the blood sample is peripheral blood or venous blood.
6. The method according to claim 4, wherein the step S104 specifically comprises:
s1041: taking out the consumable material through the transfer mechanism, and placing the consumable material in a corresponding reagent disk unpacking module or a reagent strip unpacking module for unpacking;
s1042: transferring the unpacked consumable to the chromatographic incubation zone or the reagent tray sample loading zone;
s1043: dispensing the reagent in the reagent tube and the blood sample through the pipetting mechanism;
s1044: and detecting the distributed blood sample through the biochemical detection module, the immunochromatography detection module and the blood routine detection module.
7. The method for detecting blood according to claim 6, wherein S1043 specifically comprises:
S1043A: drawing a blood sample from the sample site by the pipetting mechanism, adding the blood sample to the biochemical reagent disk, the chromatographic reagent strip and the WBC counting cell of the blood routine detection module;
S1043B: diluting the blood sample in the WBC counting tank, extracting the diluted blood sample, and adding the diluted blood sample into the RBC counting tank of the blood routine detection module;
S1043C: moving a puncture sample adding needle of the pipetting mechanism to the needle washing table, and washing the inside, the outside and the pipeline of the puncture sample adding needle;
S1043D: adding the reagent in the reagent tube to the chromatographic reagent strip;
S1043E: and washing the puncture sample adding needle to finish the distribution of the reagent and the blood sample.
8. The method for detecting blood according to claim 6, wherein S1044 specifically comprises:
S1044A: collecting blood routine detection results through the blood routine detection module for novel blood cell count, white blood cell classification and hemoglobin concentration measurement of the blood sample;
S1044B: transferring the biochemical reagent disk to the biochemical detection module through the transfer mechanism for detection, diluting a blood sample in the biochemical reagent disk by the biochemical detection module, centrifugally separating the diluted blood sample to obtain serum, detecting the serum, and collecting a biochemical detection result;
S1044C: and incubating the chromatographic reagent strip for a preset period of time at room temperature, transferring the incubated chromatographic reagent strip to the immunochromatography detection module for detection through the transfer mechanism, obtaining a fluorescence signal value of the chromatographic reagent strip, and obtaining an immunochromatography detection result.
9. The blood detection method according to claim 6, wherein S104 further comprises:
s1045: inputting the blood routine detection result, the biochemical detection result and the immunochromatographic detection result into the programmable computer.
10. The blood test method of claim 3, wherein the blood test method further comprises:
S105A: and transmitting the report to a laboratory information management system.
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