CN107290562A - A kind of automatic sample handling system detected for sample cell high flux - Google Patents
A kind of automatic sample handling system detected for sample cell high flux Download PDFInfo
- Publication number
- CN107290562A CN107290562A CN201710725467.6A CN201710725467A CN107290562A CN 107290562 A CN107290562 A CN 107290562A CN 201710725467 A CN201710725467 A CN 201710725467A CN 107290562 A CN107290562 A CN 107290562A
- Authority
- CN
- China
- Prior art keywords
- sample
- disc
- sample cell
- model
- export
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
Abstract
The invention discloses a kind of automatic sample handling system detected for sample cell high flux, including the sample disc for placing multitube sample cell, the sample disc is arranged on on model by rotating mechanism, it is described enter model be connected by entering export drive mechanism with sample introduction back box, the sample disc is in the presence of export drive mechanism is entered relative to sample introduction back box warehouse entry or export, in warehouse entry state, multitube sample cell in the sample disc coordinates with sample cell hoisting mechanism respectively carries out lifting suction sample, in export state, multitube sample cell in the sample disc can be changed.The sample disc of the present invention is in warehouse entry state, it can coordinate with sample cell hoisting mechanism, realize sample cell sample introduction in sample disc, in export state, sample disc can be taken out and is easy in system the replacing of sample cell, there is the present invention sample disc can be taken off, automate into export and sample cell rotational positioning and the function of lifting sample introduction, and the high flux for effectively realizing multitube sample cell is continuously detected.
Description
Technical field
It is more particularly to a kind of to be used for what sample cell high flux was detected the invention belongs to blood cell analysis equipment technical field
Automatic sample handling system.
Background technology
The vitro diagnosis assays instrument of blood, such as blood cell analyzer and stream type cell analyzer, in clinical user
Daily use in can often run into the test of a large amount of samples, the detection of such as blood routine, the analysis of lymphocyte subgroup, average daily inspection
Measurement can reach hundreds of pipe samples.For clinical user, automation equipment, intellectuality are improved, is reduced to operating personnel's time
Occupancy, be the important core bright spot of instrument.
When cytoanalyze carries out sample diagnosis, it is necessary to by sample sampling device from heparin tube or test tube, draw
The samples such as the cell after a certain amount of fluorescence labeling, and pass through sample introduction capillary or sampling needle；The sample of absorption is injected thin again
Born of the same parents' analysis cell or flow chamber, and recognized successively by instrument detection.For various QC it is continuous, automation detection, generally
Also to coordinate the motion control device of various dimensions, and be mutually linked cooperation, so as to realize that the full-automation to sample to be analysed takes
Sample and analysis.
In this professional domain, the sampling device that forefathers are had been carried out in some explorations, such as automatic sampler may be designed as
In the movement of horizontal X axles, longitudinal direction Y axles and vertical Z axles three degree of freedom, but belong to universal design, it is less efficient and equal
Larger space can be taken.
Such as the Chinese patent that number of patent application is 201210133808.8, it is proposed that comprising sample tray and positioning knob,
The auto injection scheme of pallet rotating actuator, pallet lift transmission mechanism, tests for 96 holes and 384 holes, employs sample
Product pallet lift, the control mode of horizontal rotation, but it is not suitable for the clinical blood sample such as heparin tube and 5mL flow cytometer showed pipes
Analysis.
For example number of patent application is 201210088038.X Chinese patent, and being proposed for cellanalyzer can be to sample
Product are loaded, pulled, mixing, puncturing sampling, the integrated apparatus of unloading, it is proposed that full-automatic feasible solution,
But the device uses the scheme that sample cell moves linearly, overall to take substantial amounts of spatial volume, such as sample cell increases from 10 pipes
The increase of system bulk at double will be brought to 20 pipes.
For another example number of patent application is 201410221782.1 Chinese patent, it is proposed that for the full-automatic of flow cytometer
Sample introduction mechanism, disclose can inside and outside two circle place the rotating disk of samples, control sample pin along X to doing horizontal reciprocating movement
Drive mechanism（For Internal and external cycle sampling）, control rotating disk do the vertical reciprocating drive mechanism of Z-direction.Scenario-frame is tighter
Gather, but how the program automates the scheme of rotation selection sample cell without reference to rotating disk, and also rotating disk fixes not side
Just clinical user mass places sample test cell, still there is larger room for improvement.
Therefore, how user is facilitated quickly to place sample cell（Including heparin tube or test tube）, saving spatial volume premise
The flux of the lower increase continuous detection sample cell of single（For example it is more than 30 pipes）, realize and sample feeding pipe is individually addressed selection, and it is full
Pollution-free, personal security the principle that podiatrist treats, is the main target for automating sample sampling device.
The content of the invention
It is an object of the invention to：For above-mentioned problem solution blood cell analyzer is put forth effort on there is provided one kind
In the clinical instrument such as stream type cell analyzer, automation carries out transfer with high throughput, individually addressing selection, continuous to sample cell
Property sample introduction requirement be used for sample cell high flux detect automatic sample handling system.
The technical proposal of the invention is realized in this way：A kind of automatic sample handling system detected for sample cell high flux,
Including the sample disc for placing multitube sample cell, the sample disc is arranged on on model by rotating mechanism, and its feature exists
In：It is described enter model be connected by entering export drive mechanism with sample introduction back box, be arranged on it is described enter model on sample disc entering
Relative to sample introduction back box warehouse entry or export in the presence of export drive mechanism, in warehouse entry state, the multitube in the sample disc
Sample cell coordinates with sample cell hoisting mechanism respectively carries out lifting suction sample, can be in the sample disc in export state
Multitube sample cell is changed.
The automatic sample handling system of the present invention detected for sample cell high flux, enters export drive mechanism bag described in it
Line slide rail module, support post and linear drive apparatus are included, the support post is fixedly connected in sample introduction back box, described
Line slide rail module links together with support post, it is described enter model be slidably arranged on line slide rail module and and straight line
Drive device connect, it is described enter model warehouse entry and the linearly operating of export are completed in the presence of linear drive apparatus.
The automatic sample handling system of the present invention detected for sample cell high flux, entering model described in it is included into model
Substrate and the protrusion connecting portion of bottom, it is described enter model substrate in the middle part of for depression platform, the prominent connecting portion dashes forward downwards
For depression platform side wall and be connected with linear drive apparatus, it is described enter model substrate depression platform both sides set respectively
There is the line slide rail module set on the support post of parallel arrangement, the support post with entering the convex of model substrate both sides formation
Platform corresponding matching, the line slide rail module is used for into linear slide of the model substrate relative to support post.
The automatic sample handling system of the present invention detected for sample cell high flux, its described linear drive apparatus includes
Linear drive motor, synchronous cog belt, driving wheel and driven pulley, the linear drive motor are fixedly connected on support post,
The driving wheel and the clutch end of linear drive motor are connected, and the driven pulley is rotatably arranged on support post,
The synchronous cog belt two ends are around being connected on driving wheel and driven pulley, and the synchronous cog belt is by connection component and enters model
Prominent connecting portion is connected, it is described enter model be synchronized with the movement with synchronous cog belt.
The automatic sample handling system of the present invention detected for sample cell high flux, its described rotating mechanism includes rotation
Transmission device and rotating driving device, the rotary actuator include from top to bottom be sequentially arranged sample disc button, space disc,
Swivel bearing, synchromesh gear, rotation code-disc and end cap, the sample disc button, space disc, synchromesh gear, rotation code-disc and
End cap is fixed together composition overall structure, the sample disc button and sample disc detachable connection, institute by connector
The bottom that end cap is arranged at rotation code-disc is stated, the synchromesh gear and rotation code-disc are socketed on swivel bearing, and pass through rotation
Bearing is connected with entering model rotation.
The automatic sample handling system of the present invention detected for sample cell high flux, its described rotating driving device is fixed
On model is entered, the lateral position of swivel bearing, the rotating driving device drives sample disc by rotary actuator
Rotate, it includes rotary drive motor, flat-toothed belt and rotating driver, and the rotary drive motor is fixedly installed on sample introduction
On plate, and the power output shaft of the rotary drive motor is passed through and is connected into model with rotating driver, the flat-toothed belt
Two ends are around being connected on synchromesh gear and rotating driver, to drive synchromesh gear to rotate.
It is of the present invention for sample cell high flux detect automatic sample handling system, its it is described enter model on be provided with
Code disc optoelectronic sensor and positioning photoelectric sensor, the code disc optoelectronic sensor coordinates with rotation code-disc, for judging rotation
The rotational angle of transmission device, the positioning photoelectric sensor and the detent fit being arranged on end cap, for determining rotation
The original position of transmission device, the synchronous cog belt is laterally additionally provided with another positioning photoelectric sensor, for judging sample introduction
The position of plate, the linear drive motor, rotary drive motor, code disc optoelectronic sensor and two positioning photoelectric sensors point
It is not connected with the drive control plate being arranged in sample introduction back box, the drive control plate is used to control linear drive motor and rotation
The rotation of motor, and read the movable information that code-disc photoelectric sensor and two positioning photoelectric sensors are obtained.
The automatic sample handling system of the present invention detected for sample cell high flux, it sets in the sample introduction back box periphery
Bin shell is equipped with, the bin shell includes bottom enclosure, front panel, back shroud and upper lid, and the bottom enclosure is installed
To the planar base of sample introduction back box, the front panel is that circular arc facade and internal diameter are more than sample dish external diameter, and be attached into
The front of model, the back shroud is attached to the left and right side and the back side of sample introduction back box, and the upper lid is installed by rotation hinge
To back shroud upper surface, in the case where entering model export state, the upper lid opens up and then proposes sample disc, enters entering model
Under the state of storehouse, the bin shell forms relatively closed environment.
The automatic sample handling system of the present invention detected for sample cell high flux, its described sample disc is in integrally cylinder
Shape structure, some cellular through holes of a circle are provided with the sample disc excircle, and the via bottoms gradually taper up to be formed
Supporting part for supporting sample bottom of the tube, the opening of the via bottoms, which is more than, is arranged on sample cell elevator below sample disc
The sample lifting arm of structure is used for the support lifting end for supporting and being lifted sample cell, in lifting process, the sample lifting arm
Support lifting end through the through hole in sample disc, and supporting the sample bottom of the tube being positioned in through hole rises it, and
Sample cell upper end opening portion and swab bottom is set to be fitted close to form sealing, the sample cell and swab are transported tight fit is synchronous
Opposing seal state is remained during dynamic.
The automatic sample handling system of the present invention detected for sample cell high flux, its described sample disc includes mutually interconnecting
Lid and sample cell honeybee slotted disk, some sample pipe through-holes are provided with the sample disc cover rim in the sample disc being connected together,
Some sample pipe through-holes are corresponded and connected with some sample cell honeybee slotted eyes that sample cell honeybee slotted disk edge is set, in institute
State and be provided with handle in sample disc on lid, the sample cell honeybee slotted disk bottom and rotating mechanism detachable connection.
The present invention makes sample disc in warehouse entry state by being designed as sample disc to enter the state of export, can be with sample
QC hoisting mechanism coordinates, and realizes the sample introduction of sample cell in sample disc, in addition, sample disc is in export state, can be by sample
Disk takes out and is easy to the replacing of sample cell in system, and there is the present invention sample disc can be taken off, automate into export and sample
Pipe rotational positioning and the function of lifting sample introduction, the high flux for effectively realizing multitube sample cell are continuously detected.
Brief description of the drawings
Fig. 1 and Fig. 2 are the structural representations of the present invention.
Fig. 3 is structural representation of the sample disc in warehouse entry state in the present invention.
Fig. 4 is structural representation of the sample disc in export state in the present invention.
Fig. 5 is to enter the structural representation that export drive mechanism is connected with sample introduction back box in the present invention.
Fig. 6 is the structural representation of cathetus drive device of the present invention.
Fig. 7 be in the present invention a kind of rotary actuator of structure with entering the structural representation that model is connected.
Fig. 8 is Fig. 7 sectional view.
Fig. 9 is the structural representation of rotary actuator in Fig. 7.
Figure 10 is Fig. 9 sectional view.
Figure 11 is the structural representation of swivel bearing in Figure 10.
Figure 12 is the rotary actuator of another structure in the present invention with entering the structural representation that model is connected.
Figure 13 is the structural representation of rotary actuator in Figure 12.
Figure 14 is the structural representation of sample disc in the present invention.
Figure 15 is that sample cell is positioned over the schematic diagram in sample disc in the present invention.
Figure 16 is the sample cell hoisting mechanism and the schematic diagram of sample disc cooperation in the present invention.
Figure 17 is the position view of sample disc respectively in warehouse entry and export in the present invention.
Figure 18 is the schematic diagram that sample cell hoisting mechanism is lifted to sample cell in the present invention.
Marked in figure：1 is sample cell, and 2 be sample disc, and 3 be that, into model, 4 be sample introduction back box, and 5 be sample cell hoisting mechanism,
6 be line slide rail module, and 7 be support post, and 8 be linear drive apparatus, and 9 be rotary actuator, and 10 be rotating driving device,
11 be code disc optoelectronic sensor, and 12 be positioning photoelectric sensor, and 13 be drive control plate, and 14 be bin shell, and 15 be swab, 16
It is sampling needle rack for sampling needle, 17,18 be substrate, and 19 be swab sliding equipment, and 21 be to be covered in sample disc, and 22 be sample cell honeybee
Slotted disk, 23 be handle, and 31 be that, into model substrate, 32 is protrude connecting portion, and 33 be platform, and 41 be planar base, and 51 carry for sample
Rising stem, 81 be linear drive motor, and 82 be synchronous cog belt, and 83 be driving wheel, and 84 be driven pulley, and 91 be sample disc button, and 92 are
Space disc, 93 be swivel bearing, and 94 be synchromesh gear, and 95 be rotation code-disc, and 96 be end cap, and 97 be alignment pin, and 101 drive for rotation
Dynamic motor, 102 be flat-toothed belt, and 103 be rotating driver, and 141 be bottom enclosure, and 142 be front panel, and 143 be back shroud,
144 be upper lid, and 211 be sample pipe through-hole, and 221 be sample cell honeybee slotted eye, and 511 be support lifting end, and 931 be follower shaft,
932 be deep groove ball bearing, and 933 be axle sleeve, and 934 be screw.
Embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
As Figure 1-4, a kind of automatic sample handling system detected for sample cell high flux, including for placing multitube sample
The sample disc 2 of QC 1, the sample cell 1 is the containment device of cell analysis testing sample, is often the cylindrical tube of bottom hemispherical
Shape structure, it is centrifuged including but not limited to medical vacuum heparin tube, flow cytometer showed with 5mL sample cells and 1~5mL of Bioexperiment
Pipe etc., the sample disc 2 is arranged on on model 3 by rotating mechanism, it is described enter model 3 by entering export drive mechanism with entering
Sample back box 4 is connected, the sample introduction back box 4 generally four sides box body structure, wherein front is transported to the export of entering for entering model 3
It is dynamic, be arranged on it is described enter model 3 on sample disc 2 in the presence of export drive mechanism is entered relative to the warehouse entry of sample introduction back box 4 or
Export, bin shell 14 is provided with the periphery of sample introduction back box 4, and the bin shell 14 includes bottom enclosure 141, front panel
142nd, back shroud 143 and upper lid 144, the bottom enclosure 141 are attached to the lower section of planar base 41 of sample introduction back box 4, described
Front panel 142 is circular arc facade and internal diameter is more than the external diameter of sample disc 2, and is attached into the front of model 3, the back shroud
143 are attached to the left and right side and the back side of sample introduction back box 4, and the upper lid 144 is attached to the upper table of back shroud 143 by rotation hinge
Face, in the case where entering the export state of model 3, the upper lid 144 opens up and then proposes sample disc 2, can be to the sample disc 2
On multitube sample cell 1 changed, in the case where entering the warehouse entry state of model 3, the bin shell 14 forms relatively closed environment,
Multitube sample cell 1 in the sample disc 2 coordinates with sample cell hoisting mechanism 5 respectively carries out lifting suction sample, passes through bin shell
Setting, it is ensured that the lifting sample introduction of sample cell is detected in the environment of relative closure, can both avoid dirt of the environment to sample
Dye, can also avoid damage of the high-speed moving part to medical personnel.
Wherein, it is described enter export drive mechanism include line slide rail module 6, support post 7 and linear drive apparatus 8,
The support post 7 is fixedly connected in sample introduction back box 4, and the line slide rail module 6 links together with support post 7, institute
State and be slidably arranged on line slide rail module 6 and be connected with linear drive apparatus 8 into model 3, it is described enter model 3 straight line drive
Warehouse entry and the linearly operating of export are completed in the presence of dynamic device 8；It is described enter model 3 be main motion carrier, it include into
Model substrate 31 and the protrusion connecting portion 32 of bottom, it is described enter the generally rectangular sheet metal structural of model substrate 31, its middle part be
The platform 33 of depression, the rotating mechanism is fixed to the middle part of depression platform 33, and the prominent connecting portion 32 protrudes downward from recessed
Fall into platform 33 side wall and be connected with linear drive apparatus 8, it is described enter model substrate 31 the both sides of depression platform 33 set respectively
The support post 7 of parallel arrangement is equipped with, the spacing of two support posts 7 is equal into the both sides boss distance of model substrate 31, described
The line slide rail module 6 set on support post 7 and the boss corresponding matching for entering the formation of the both sides of model substrate 31, the straight line are slided
Rail module 6 is used for into linear slide of the model substrate 31 relative to support post 7.
As it can be seen in figures 5 and 6, the linear drive apparatus 8 includes linear drive motor 81, synchronous cog belt 82, driving wheel
83 and driven pulley 84, the linear drive motor 81 is fixedly connected on support post 7, the driving wheel 83 and linear drives electricity
The clutch end connection of machine 81, the driven pulley 84 is rotatably arranged on support post 7,82 liang of the synchronous cog belt
End is around being connected on driving wheel 83 and driven pulley 84, and the synchronous cog belt 82 is connected by connection component with entering the protrusion of model 3
Portion 32 is connected, it is described enter model 3 be synchronized with the movement with synchronous cog belt 82, and then complete the motion into model warehouse entry and export
Control.
As is seen in figs 7-10, the rotating mechanism is used to coordinate there is provided accurate rotational positioning and control with sample disc 2,
It includes rotary actuator 9 and rotating driving device 10, and the rotary actuator 9 includes the sample being from top to bottom sequentially arranged
Product disk buckles 91, space disc 92, swivel bearing 93, synchromesh gear 94, rotation code-disc 95 and end cap 96, the sample disc button 91,
Space disc 92, synchromesh gear 94, rotation code-disc 95 and end cap 96 are fixed together composition overall structure by connector,
The sample disc button 91 and the detachable connection of sample disc 2, and synchronous axial system is realized, the end cap 96 is arranged at rotation code-disc 95
Bottom, the synchromesh gear 94 and rotation code-disc 95 be socketed on swivel bearing 93, and by swivel bearing 93 and entering model 3
Rotate connection；The rotating driving device 10 is fixed on on model 3, the lateral position of swivel bearing 93, the rotation driving
Device 10 drives sample disc 2 to rotate by rotary actuator 9, and it includes rotary drive motor 101, flat-toothed belt
102 and rotating driver 103, the rotary drive motor 101 is fixedly installed on on model 3, and the rotary drive motor
101 power output shaft is passed through to be connected into model 3 with rotating driver 103, and the two ends of flat-toothed belt 102 are around being connected on synchronization
On gear 94 and rotating driver 103, to drive synchromesh gear 94 to rotate.
Wherein, it is described enter model 3 on be provided with code disc optoelectronic sensor 11 and positioning photoelectric sensor 12, the code-disc
Photoelectric sensor 11 is U-shaped photoelectric sensor, and is arranged on the offside of rotating driving device 10, the code disc optoelectronic sensor 11
Coordinate with rotation code-disc 95, the rotational angle for judging rotary actuator 9, accurately to control the anglec of rotation of sample disc,
The positioning photoelectric sensor 12 coordinates with the alignment pin 97 being arranged on end cap 96, for determining rising for rotary actuator 9
Beginning position, use cooperatively and position photoelectric sensor 12 and alignment pin with rotation code-disc 95 by code disc optoelectronic sensor 11
97 use cooperatively, accurately controls the absolute position of sample disc and the angle of relative rotation；The synchronous cog belt 82 is lateral
Another positioning photoelectric sensor is additionally provided with, for judging into the position of model 3, the linear drive motor 81, rotation driving
Motor 101, the driving of code disc optoelectronic sensor 11 and two positioning photoelectric sensors 12 respectively with being arranged in sample introduction back box 4
Control panel 13 is connected, and the drive control plate 13 is used for the rotation for controlling linear drive motor 81 and rotary drive motor 101, and
Read the movable information that code-disc photoelectric sensor 11 and two positioning photoelectric sensors 12 are obtained.Wherein drive control plate is used for electricity
The scheme of machine driving, including but not limited to conventional drive and control of electric machine chip TMC2660, L298N etc., the simulation of photoelectric sensor
Output signal transfers to control system to handle after being gathered by analog/digital converter.The integral installation of drive control plate 13 in
In sample introduction back box 4, close to the side of Left-side support column 7.
As shown in figure 11, the swivel bearing 93 includes follower shaft 931, deep groove ball bearing 932, axle sleeve 933 and screw
934 are constituted, wherein the follower shaft 931 passes through the mounting hole into the center of depression platform 33 of model 3, two deep groove ball bearings
932 provide the rotation relative to follower shaft 931, and the axle sleeve 933 is interval in the middle of two deep groove ball bearings 932 so that three
The height of person is identical with the height of rotation code-disc 95 and synchromesh gear 94, and the internal diameter of two deep groove ball bearings 932 and axle sleeve 933 is equal
The external diameter of follower shaft 931 is placed on, the screw 934 is fixed on on model substrate 31 through the axis of a movable block 931.
Wherein, the sample disc button 91 is used to coordinate with the bottom close installation of sample disc 2, can include a variety of designs,
For example, as shown in Figure 9 is a boss structure, its rounded bottom is provided with and the corresponding screwed hole of space disc 92, protrusion step
Portion is breach cylinder, and the bottom of sample disc 2 is set to corresponding concave inward structure；Or, as shown in Figures 12 and 13, or a circle
Dish structure, its center be provided with the corresponding screwed hole of space disc 92, disk border be provided with breach, for corresponding to sample disc 2 convex
Go out the cooperation of structure.
As shown in FIG. 14 and 15, the overall cylindrical structure of the sample disc 2, is provided with the excircle of sample disc 2
One some cellular through holes of circle, the via bottoms gradually taper up the supporting part to be formed for supporting the bottom of sample cell 1, described
The opening of via bottoms is more than the sample lifting arm 51 for being arranged on the lower section sample cell hoisting mechanism 5 of sample disc 2 for supporting and carrying
The support lifting end 511 of sample cell 1 is risen, in lifting process, the support lifting end 511 of the sample lifting arm 51 is passed through
Through hole in sample disc 2, and supporting the bottom of sample cell 1 being positioned in through hole rises it, and make the upper end open of sample cell 1
Portion is fitted close to form sealing with the bottom of swab 15, and the sample cell 1 begins with swab 15 during tight fit is synchronized with the movement
Opposing seal state is kept eventually.
Wherein, the sample disc 2 includes lid 21 and sample cell honeybee slotted disk 22 in the sample disc that interconnects, in institute
State the edge of lid 21 in sample disc and be provided with some sample pipe through-holes 211, some sample pipe through-holes 211 and sample cell honeybee slotted disk
Some sample cell honeybee slotted eyes 221 that 22 edges are set are corresponded and connected, and handle is provided with lid 21 in the sample disc
23, the handle 23 uses door handle shape structure, and hand grip portion one end is that tip is indicated for sample cell, the sample cell honeybee slotted disk
22 bottoms be provided with groove corresponding with the size of sample disc button 91 or projective structure, for rotating mechanism detachable connection,
And be rotatably assorted with the formation of sample disc button 91., can be singlehanded by sample disc in the state of sample disc export by holding handle
It is overall to propose, in order to the replacing of multitube sample cell and loading in sample disc.
As shown in Figure 16,17 and 18, in the present embodiment, sample cell hoisting mechanism 5 coordinates with sampling needle 16 and swab 15
Use, the sampling needle 16 is fixedly installed on sampling needle rack 17, the sampling needle rack 17 is fixedly connected with substrate 18,
Swab sliding equipment 19 and sample cell hoisting mechanism 5, the swab 15 and swab sliding equipment are provided with the substrate 18
19 connections, the sample cell 1 is positioned on sample cell hoisting mechanism 5, effect of the sample cell hoisting mechanism 5 in drive mechanism
Under be lifted up, in lifting process, the upper end opening portion of sample cell 1 and the bottom of swab 15, which are fitted close, to form sealing and will
The jack-up of swab 15, the sample cell hoisting mechanism 5 and swab sliding equipment 19 are synchronized with the movement, and the sample cell hoisting mechanism 5 can
Complete the relative movement and position control and sampling needle 16 of the absorption transfer, swab 15 of sample in sample cell 1 with sampling needle 16
The cleaning function of inside and outside wall.
The present invention operation principle be：
Sample introduction stage, various kinds QC 1（Such as 32 blood sampling tube pipes）It is positioned over after sample disc 2, sample introduction is driven by entering export drive mechanism
Inwardly motion completes warehouse entry action to plate 3；The accurate selection of sample cell 1 is completed with rotating mechanism again；And it is last by sample cell
The sample cell 1 is lifted up by hoisting mechanism 5, inserts the inner bottom part of sample cell 1 to sampling needle 16, by the pipette samples of sampling needle 16 simultaneously
Inject cell analysis pond or flow chamber.
Vary the stage, sample cell hoisting mechanism 5 first separates sample cell 1 with sampling needle 16, and complete in sampling needle 16
The cleaning of outer wall；Sample cell 1 is reset in its original cellular through hole in sample disc again, rotating mechanism 2 will be lower the same
QC 1 is rotated to the lower section of sampling needle 16；Lifted again by sample cell hoisting mechanism 5, sampling needle 16 is sampled.
Export stage, sample cell 1 completes to reset, and in the cellular through hole in sample disc；Rotating mechanism is by sample
The handle 23 of product disk 2 is rotated to the position of tip inward；Drive to move out into model 3 by entering export drive mechanism and complete export
Action, now user can perform fighting the upper lid 144 of bin shell 14, sample disc 2 is entirely proposed, and carry out the replacement of sample cell 1.
The independent addressing selection of high flux test tube in the present invention, by rotating stepper motor, code disc optoelectronic sensor and fixed
Position photoelectric sensor complete, sample disc button, swivel bearing, synchromesh gear and rotate code-disc close fit there is provided can be axial
Fixed, tangential flexible rotating and part can the feasibilities that coordinate of quick-speed plug.The export of entering of Electronic control sample disc is acted, can
Facilitate the overall taking-up of sample disc, and build closed environment.The taking-up of sample disc is that clinical user is brought greatly just
Victory, separate unit instrument can be equipped with multiple sample discs, further save the operating efficiency of personnel.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
1. a kind of automatic sample handling system detected for sample cell high flux, including for placing multitube sample cell（1）Sample
Disk（2）, the sample disc（2）It is arranged on by rotating mechanism into model（3）On, it is characterised in that：It is described enter model（3）Pass through
Enter export drive mechanism and sample introduction back box（4）Connection, be arranged on it is described enter model（3）On sample disc（2）Entering export driving
Relative to sample introduction back box in the presence of mechanism（4）Warehouse entry or export, in warehouse entry state, the sample disc（2）On multitube sample
QC（1）Respectively with sample cell hoisting mechanism（5）Coordinate and carry out lifting suction sample, can be to the sample disc in export state
（2）On multitube sample cell（1）Changed.
2. the automatic sample handling system according to claim 1 detected for sample cell high flux, it is characterised in that：It is described enter
Export drive mechanism includes line slide rail module（6）, support post（7）And linear drive apparatus（8）, the support post
（7）It is fixedly connected on sample introduction back box（4）It is interior, the line slide rail module（6）With support post（7）Link together, it is described enter
Model（3）It is slidably arranged in line slide rail module（6）Upper and and linear drive apparatus（8）Connection, it is described enter model（3）Straight
Line drive device（8）In the presence of complete the linearly operating of warehouse entry and export.
3. the automatic sample handling system according to claim 2 detected for sample cell high flux, it is characterised in that：It is described enter
Model（3）Including entering model substrate（31）And the protrusion connecting portion of bottom（32）, it is described enter model substrate（31）Middle part is recessed
Sunken platform（33）, the prominent connecting portion（32）Protrude downward from the platform that is recessed（33）Side wall and and linear drive apparatus
（8）Connection, it is described enter model substrate（31）Depression platform（33）Both sides are respectively arranged with the support post of parallel arrangement
（7）, the support post（7）The line slide rail module of upper setting（6）With entering model substrate（31）The boss correspondence that both sides are formed
Coordinate, the line slide rail module（6）For entering model substrate（31）Relative to support post（7）Linear slide.
4. the automatic sample handling system according to claim 3 detected for sample cell high flux, it is characterised in that：It is described straight
Line drive device（8）Including linear drive motor（81）, synchronous cog belt（82）, driving wheel（83）And driven pulley（84）, it is described
Linear drive motor（81）It is fixedly connected on support post（7）On, the driving wheel（83）With linear drive motor（81）It is dynamic
Power output end is connected, the driven pulley（84）It is rotatably arranged in support post（7）On, the synchronous cog belt（82）Two ends
Around being connected on driving wheel（83）And driven pulley（84）On, the synchronous cog belt（82）By connection component with entering model（3）It is prominent
Go out connecting portion（32）Connect, it is described enter model（3）With synchronous cog belt（82）It is synchronized with the movement.
5. the automatic sample handling system according to claim 4 detected for sample cell high flux, it is characterised in that：The rotation
Rotation mechanism includes rotary actuator（9）And rotating driving device（10）, the rotary actuator（9）Including from top to bottom according to
The sample disc button of secondary arrangement（91）, space disc（92）, swivel bearing（93）, synchromesh gear（94）, rotation code-disc（95）And end
Lid（96）, the sample disc button（91）, space disc（92）, synchromesh gear（94）, rotation code-disc（95）And end cap（96）Pass through
Connector is fixed together composition overall structure, the sample disc button（91）With sample disc（2）Detachable connection, it is described
End cap（96）It is arranged at rotation code-disc（95）Bottom, the synchromesh gear（94）With rotation code-disc（95）It is socketed in swivel bearing
（93）On, and pass through swivel bearing（93）With entering model（3）Rotate connection.
6. the automatic sample handling system according to claim 5 detected for sample cell high flux, it is characterised in that：The rotation
Rotary driving device（10）It is fixed on into model（3）Upper, swivel bearing（93）Lateral position, the rotating driving device（10）It is logical
Cross rotary actuator（9）Drive sample disc（2）Rotate, it includes rotary drive motor（101）, flat-toothed belt
（102）And rotating driver（103）, the rotary drive motor（101）It is fixedly installed on into model（3）On, and the rotation
Motor（101）Power output shaft pass through into model（3）With rotating driver（103）Connection, the flat-toothed belt
（102）Two ends are around being connected on synchromesh gear（94）With rotating driver（103）On, to drive synchromesh gear（94）Rotate.
7. the automatic sample handling system according to claim 6 detected for sample cell high flux, it is characterised in that：Described
Enter model（3）On be provided with code disc optoelectronic sensor（11）With positioning photoelectric sensor（12）, the code disc optoelectronic sensor
（11）With rotation code-disc（95）Coordinate, for judging rotary actuator（9）Rotational angle, the positioning photoelectric sensor
（12）With being arranged on end cap（96）On alignment pin（97）Coordinate, for determining rotary actuator（9）Original position, it is described
Synchronous cog belt（82）Another positioning photoelectric sensor is laterally additionally provided with, for judging into model（3）Position, the straight line
Motor（81）, rotary drive motor（101）, code disc optoelectronic sensor（11）And two positioning photoelectric sensors（12）Point
Not with being arranged on sample introduction back box（4）Interior drive control plate（13）Connection, the drive control plate（13）For controlling straight line to drive
Dynamic motor（81）And rotary drive motor（101）Rotation, and read code-disc photoelectric sensor（11）With two positioning photoelectric transfers
Sensor（12）The movable information of acquisition.
8. the automatic sample handling system according to claim 1 detected for sample cell high flux, it is characterised in that：Described
Sample introduction back box（4）Periphery is provided with bin shell（14）, the bin shell（14）Including bottom enclosure（141）, front panel
（142）, back shroud（143）And upper lid（144）, the bottom enclosure（141）It is attached to sample introduction back box（4）Planar base
（41）Lower section, the front panel（142）It is more than sample disc for circular arc facade and internal diameter（2）External diameter, and be attached into model（3）'s
Front, the back shroud（143）It is attached to sample introduction back box（4）Left and right side and the back side, the upper lid（144）Closed by rotating
Page is attached to back shroud（143）Upper surface, is entering model（3）Under export state, the upper lid（144）Open up and then by sample
Product disk（2）Propose, entering model（3）Under warehouse entry state, the bin shell（14）Form relatively closed environment.
9. the automatic sample handling system as claimed in any of claims 1 to 8 detected for sample cell high flux, it is special
Levy and be：The sample disc（2）Overall cylindrical structure, in the sample disc（2）Excircle is provided with some honeycombs of a circle
The through hole of shape, the via bottoms gradually taper up to be formed for supporting sample cell（1）The supporting part of bottom, the via bottoms
Opening, which is more than, is arranged on sample disc（2）Lower section sample cell hoisting mechanism（5）Sample lifting arm（51）For supporting and being lifted sample
QC（1）Support lifting end（511）, in lifting process, the sample lifting arm（51）Support lifting end（511）
Through sample disc（2）On through hole, and support the sample cell being positioned in through hole（1）Bottom rises it, and makes sample cell
（1）Upper end opening portion and swab（15）Bottom is fitted close to form sealing, the sample cell（1）With swab（15）It is being fitted close
Opposing seal state is remained during being synchronized with the movement.
10. the automatic sample handling system according to claim 9 detected for sample cell high flux, it is characterised in that：It is described
Sample disc（2）Including being covered in the sample disc that interconnects（21）With sample cell honeybee slotted disk（22）, in the sample disc
Lid（21）Edge is provided with some sample pipe through-holes（211）, some sample pipe through-holes（211）With sample cell honeybee slotted disk（22）
Some sample cell honeybee slotted eyes that edge is set（221）Correspond and connect, covered in the sample disc（21）On be provided with and carry
Hand（23）, the sample cell honeybee slotted disk（22）Bottom and rotating mechanism detachable connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710725467.6A CN107290562B (en) | 2017-08-22 | 2017-08-22 | A kind of automatic sample handling system for the detection of sample cell high throughput |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710725467.6A CN107290562B (en) | 2017-08-22 | 2017-08-22 | A kind of automatic sample handling system for the detection of sample cell high throughput |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107290562A true CN107290562A (en) | 2017-10-24 |
| CN107290562B CN107290562B (en) | 2019-09-06 |
Family
ID=60107131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710725467.6A Active CN107290562B (en) | 2017-08-22 | 2017-08-22 | A kind of automatic sample handling system for the detection of sample cell high throughput |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107290562B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107643418A (en) * | 2017-11-14 | 2018-01-30 | 博奥颐和健康科学技术（北京）有限公司 | Alignment system and its locating calibration device |
| CN107748271A (en) * | 2017-11-27 | 2018-03-02 | 桂林优利特医疗电子有限公司 | Adapt to the blood analyser list sampling device of different test tubes |
| CN109060641A (en) * | 2018-10-31 | 2018-12-21 | 江苏卓微生物科技有限公司 | Porous sample introduction cell counter |
| CN109682765A (en) * | 2018-12-31 | 2019-04-26 | 天津精益宽谱科技有限公司 | A kind of spectroanalysis instrument with automatic replacement sample |
| CN110361493A (en) * | 2019-08-07 | 2019-10-22 | 常州磐宇仪器有限公司 | A kind of multidigit automatic sampling apparatus |
| CN111521547A (en) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | Particle analyzing and sorting device and method |
| CN111883414A (en) * | 2020-07-15 | 2020-11-03 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN113353632A (en) * | 2021-06-28 | 2021-09-07 | 散裂中子源科学中心 | Automatic sample changing mechanism |
| WO2021212384A1 (en) * | 2020-04-22 | 2021-10-28 | 深圳华大智造科技股份有限公司 | Sample pretreatment system |
| CN116183792A (en) * | 2023-04-25 | 2023-05-30 | 河北普润环境工程有限公司 | Full-automatic thermal desorption device of rim plate material loading formula |
| CN110361493B (en) * | 2019-08-07 | 2024-05-10 | 常州磐宇仪器有限公司 | Multi-position automatic sample injection device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983000393A1 (en) * | 1981-07-20 | 1983-02-03 | American Hospital Supply Corp | Loading and transfer assembly for chemical analyzer |
| CN1657946A (en) * | 2004-02-19 | 2005-08-24 | 株式会社Ids | Sampling and dispensing apparatus |
| CN105004873A (en) * | 2015-07-19 | 2015-10-28 | 武汉明德生物科技股份有限公司 | Centrifugal rotary disk mechanism of full-automatic immunity quantitative analyzer |
| CN106370476A (en) * | 2016-08-31 | 2017-02-01 | 武汉明德生物科技股份有限公司 | Pressure tube mechanism for full-automatic immunoquantitation analyzer and press fit method thereof |
| CN106950391A (en) * | 2017-04-23 | 2017-07-14 | 湖南乾康科技有限公司 | A kind of disk sampling device |
| CN106996982A (en) * | 2016-01-22 | 2017-08-01 | 豪夫迈·罗氏有限公司 | Device for lifting sample cell |
| CN207133304U (en) * | 2017-08-22 | 2018-03-23 | 重庆博奥新景医学科技有限公司 | A kind of automatic sample handling system for the detection of sample cell high flux |
-
2017
- 2017-08-22 CN CN201710725467.6A patent/CN107290562B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983000393A1 (en) * | 1981-07-20 | 1983-02-03 | American Hospital Supply Corp | Loading and transfer assembly for chemical analyzer |
| CN1657946A (en) * | 2004-02-19 | 2005-08-24 | 株式会社Ids | Sampling and dispensing apparatus |
| CN105004873A (en) * | 2015-07-19 | 2015-10-28 | 武汉明德生物科技股份有限公司 | Centrifugal rotary disk mechanism of full-automatic immunity quantitative analyzer |
| CN106996982A (en) * | 2016-01-22 | 2017-08-01 | 豪夫迈·罗氏有限公司 | Device for lifting sample cell |
| CN106370476A (en) * | 2016-08-31 | 2017-02-01 | 武汉明德生物科技股份有限公司 | Pressure tube mechanism for full-automatic immunoquantitation analyzer and press fit method thereof |
| CN106950391A (en) * | 2017-04-23 | 2017-07-14 | 湖南乾康科技有限公司 | A kind of disk sampling device |
| CN207133304U (en) * | 2017-08-22 | 2018-03-23 | 重庆博奥新景医学科技有限公司 | A kind of automatic sample handling system for the detection of sample cell high flux |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107643418B (en) * | 2017-11-14 | 2021-01-26 | 博奥颐和健康科学技术（北京）有限公司 | Positioning system and positioning calibration device thereof |
| CN107643418A (en) * | 2017-11-14 | 2018-01-30 | 博奥颐和健康科学技术（北京）有限公司 | Alignment system and its locating calibration device |
| CN107748271A (en) * | 2017-11-27 | 2018-03-02 | 桂林优利特医疗电子有限公司 | Adapt to the blood analyser list sampling device of different test tubes |
| CN109060641A (en) * | 2018-10-31 | 2018-12-21 | 江苏卓微生物科技有限公司 | Porous sample introduction cell counter |
| CN109682765A (en) * | 2018-12-31 | 2019-04-26 | 天津精益宽谱科技有限公司 | A kind of spectroanalysis instrument with automatic replacement sample |
| CN110361493A (en) * | 2019-08-07 | 2019-10-22 | 常州磐宇仪器有限公司 | A kind of multidigit automatic sampling apparatus |
| CN110361493B (en) * | 2019-08-07 | 2024-05-10 | 常州磐宇仪器有限公司 | Multi-position automatic sample injection device |
| WO2021212384A1 (en) * | 2020-04-22 | 2021-10-28 | 深圳华大智造科技股份有限公司 | Sample pretreatment system |
| CN111521547A (en) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | Particle analyzing and sorting device and method |
| CN111883414A (en) * | 2020-07-15 | 2020-11-03 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN111883414B (en) * | 2020-07-15 | 2023-02-10 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN113353632A (en) * | 2021-06-28 | 2021-09-07 | 散裂中子源科学中心 | Automatic sample changing mechanism |
| CN116183792A (en) * | 2023-04-25 | 2023-05-30 | 河北普润环境工程有限公司 | Full-automatic thermal desorption device of rim plate material loading formula |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107290562B (en) | 2019-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107290562A (en) | A kind of automatic sample handling system detected for sample cell high flux | |
| CN110045134B (en) | Full-automatic chemiluminescence immunoassay instrument and use method thereof | |
| CN202075285U (en) | Minitype rotating disc type full-automatic immunoluminescence analysis system capable of adding sample in whole disc | |
| CN105929184B (en) | A kind of full-automatic illumination immunity analysis instrument | |
| CN207866714U (en) | Chemiluminescence detector | |
| CN103969459B (en) | A kind of full-automatic biochemical analysis method | |
| CA2148884C (en) | Sub-compact blood culture apparatus | |
| CN104034908B (en) | A kind of new automatic Biochemical Analyzer | |
| CN113504380A (en) | Full-automatic chemiluminescence immunoassay analyzer | |
| US10613106B2 (en) | Reaction vessel handling apparatus, testing apparatus, and methods using same | |
| CN208178045U (en) | A kind of automatic cleaning incubation mixing detection system | |
| CN108152285A (en) | A kind of fully-automatic intelligent urine iodine analyzer and its method of work | |
| CN207133304U (en) | A kind of automatic sample handling system for the detection of sample cell high flux | |
| CN109406804A (en) | Full-automatic chemiluminescence analyzer | |
| CN110327659A (en) | A kind of extraction and purification method and device based on magnetic fiber material | |
| CN208833787U (en) | Chemiluminescence detector | |
| CN208568812U (en) | A kind of Biochemical Analyzer | |
| JP3128212B2 (en) | Blood culture device | |
| CN109580596B (en) | Chemiluminescent detector, incubation device and incubation method thereof | |
| CN213739477U (en) | Clinical laboratory uses microbial cultivation ware | |
| CN210102859U (en) | Sample changing device used in high-temperature/irradiation equipment | |
| CN212800300U (en) | Detection equipment suitable for biological gene | |
| CN209264738U (en) | A kind of clinical laboratory's sample storage reaction device | |
| CN212483612U (en) | Biochemical analysis appearance feed arrangement | |
| CN105388312B (en) | Reagent storage device for fully-automatic analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |