CN207866714U - Chemiluminescence detector - Google Patents

Chemiluminescence detector Download PDF

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Publication number
CN207866714U
CN207866714U CN201721886762.1U CN201721886762U CN207866714U CN 207866714 U CN207866714 U CN 207866714U CN 201721886762 U CN201721886762 U CN 201721886762U CN 207866714 U CN207866714 U CN 207866714U
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CN
China
Prior art keywords
sample
reaction vessel
reaction
disc mechanism
buffering
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Application number
CN201721886762.1U
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Chinese (zh)
Inventor
饶微
尹力
朱亮
汤俊辉
胡毅
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Shenzhen New Industries Biomedical Engineering Co Ltd
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Shenzhen New Industries Biomedical Engineering Co Ltd
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Priority to CN201721886762.1U priority Critical patent/CN207866714U/en
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Publication of CN207866714U publication Critical patent/CN207866714U/en
Priority to DE202018106740.0U priority patent/DE202018106740U1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
    • G01N21/253Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus

Abstract

The utility model provides a kind of chemiluminescence detector, including:Reaction unit is operated for carrying reaction vessel and carrying out sample-adding sheet, reagent and incubate;The reaction unit includes for carrying the reaction vessel and the buffering disc mechanism of execution plus sample operations, and for carrying the reaction vessel and executing the reaction disc mechanism that reagent adding and incubation operate, the buffering disc mechanism reacts disc mechanism independent operating with described;Dispenser, for will be in sample and agent transfer to the reaction vessel;And sample grabs cup mechanism, for the reaction vessel in the buffering disc mechanism to be transferred in the reaction disc mechanism.Disc mechanism is buffered in this way and reacts disc mechanism independent operating, and mutual operation can be carried out at the same time and there is no interference, improve the detection speed of chemiluminescence detector, and then ensure detection efficiency.

Description

Chemiluminescence detector
Technical field
The utility model is related to chemiluminescence detection technology fields, more particularly to a kind of chemiluminescence detector.
Background technology
Chemiluminescence immunoassay is a kind of vitro detection for being combined antigen-antibody immune response and luminescence-producing reaction Analytical technology, it is based on Immunology, a variety of to detect by collecting optical signal using luminous marker as tracer signal Marker has high sensitivity, the advantage that non-specific adsorption is low, accuracy rate is high.With the high speed development of biological medicine equipment, Realize that the full-automation of chemiluminescence detector has certain condition.
Have become ripe medical diagnosis generally, based on the chemiluminescence detector of chemiluminescence immunoassay and set It is standby.However, universal chemiluminescence detector equipment price is expensive, volume is heavy, power hungry, it is difficult to universal and popularization.And With the high speed development of biological medicine equipment, realize that the full-automation of chemiluminescence detector has certain condition.
Chemiluminescence detector mainly include reaction cup loading device, sample adding device, incubation reaction device, cleaning device, Measuring device, control system and software systems.But each section of process of current chemiluminescence detector as plus reaction cup, Sample-adding this, the processes such as reagent adding and mixing be distributed in assembly line when executing, cause each section of process when being executed can holding time And larger space is occupied, the serious detection speed for restricting instrument influences detection efficiency.
Utility model content
Based on this, it is necessary to for current sample reaction each section of process execute when can holding time and occupy it is larger The problem that instrument detection speed is low caused by space, efficiency is low provides a kind of chemistry for shortening run time, improving detection efficiency Luminometer.
Above-mentioned purpose is achieved through the following technical solutions:
A kind of chemiluminescence detector, including:
Reaction unit is operated for carrying reaction vessel and carrying out sample-adding sheet, reagent adding and incubate;The reaction dress It sets including holding for carrying the reaction vessel and the buffering disc mechanism of execution plus sample operations, and for carrying the reaction Device simultaneously executes reagent adding and incubates the reaction disc mechanism of operation, and the buffering disc mechanism reacts disc mechanism and independently transport with described Row;
Dispenser, for will be in sample and agent transfer to the reaction vessel;And
Sample grabs cup mechanism, for the reaction vessel in the buffering disc mechanism to be transferred to the reaction disc mechanism In.
The dispenser includes sample charging mechanism in one of the embodiments,;The chemiluminescence detector further includes Reaction vessel automatic conveying device for conveying the reaction vessel;The reaction vessel automatic conveying device and the sample-adding Mechanism is located at the side of the buffering disc mechanism;
The chemiluminescence detector also there is new cup to grab cup mechanism, and the new cup grabs cup mechanism and corresponds to the reaction vessel Automatic conveying device is arranged with the buffering disc mechanism, for holding the reaction in the reaction vessel automatic conveying device Device is transferred to the buffering disc mechanism, and sample is transferred to the reaction vessel of the buffering disc mechanism by the sample charging mechanism In.
The chemiluminescence detector further includes the reagent storage dress for storing reagent in one of the embodiments, It sets, the reagent storage means are located at the side of the reaction disc mechanism;
The dispenser further includes pipetting device, and the pipetting device corresponds to the reaction disc mechanism and the reagent is deposited Storage device is arranged, for the reaction vessel by the agent transfer in the reagent storage means to the reaction disc mechanism In.
The chemiluminescence detector further includes cleaning device in one of the embodiments, for removing the reaction Impurity in container;The cleaning device is located at the side of the reaction unit;
Also there is the chemiluminescence detector cleaning to grab cup mechanism, and the cleaning grabs cup mechanism and corresponds to the cleaning device And the reaction disc mechanism setting, for the reaction vessel to be turned between the reaction disc mechanism and the cleaning device It moves.
The chemiluminescence detector further includes measuring device in one of the embodiments, for holding to the reaction Determinand in device is detected;The measuring device be located at it is described reaction disc mechanism side, and with the cleaning device phase Neighbour's setting;
The chemiluminescence detector, which also has to measure, grabs cup mechanism, and the measurement grabs cup mechanism and corresponds to the cleaning device And the measuring device setting, it is filled for the reaction vessel after being cleaned in the cleaning device to be transferred to the measurement In setting.
In one of the embodiments, the reaction disc mechanism include in independently operated reaction disc mechanism with react external disk Mechanism, the outer disc mechanism of the reaction accommodate the reaction vessel and execute reagent adding and operated with mixing, disc mechanism in the reaction It accommodates the reaction vessel and executes incubation operation;
The chemiluminescence detector, which also has to incubate, grabs cup mechanism, and the incubation grabs cup mechanism and corresponds to the reaction inner disc Outer disc mechanism setting is reacted with described by mechanism, for by the reaction vessel, disc mechanism to react external disk with described in the reaction It is shifted between mechanism.
The outer disc mechanism of the reaction is sheathed on the outside of disc mechanism in the reaction in one of the embodiments, described Buffering disc mechanism is located at the side of the outer disc mechanism of the reaction, and the outer disc mechanism of the reaction is coaxial with disc mechanism in the reaction Setting.
The chemiluminescence detector further includes sample conveying device in one of the embodiments, for sample is defeated It send to sample position;The sample position is located at the side of the buffering disc mechanism and the corresponding sample charging mechanism setting;It is described Sample charging mechanism is drawn sample in sample position and is transferred in the reaction vessel of the buffering disc mechanism.
The sample conveying device includes sample storing mechanism and stores machine with the sample in one of the embodiments, The sample conveying mechanism that structure is detachably connected stores multiple sample racks for being mounted with sample in the sample storing mechanism, described The sample rack is transported in the sample conveying mechanism by sample storing mechanism, and is delivered to institute by the sample conveying mechanism State sample position.
The input terminal of the sample conveying mechanism can be with the sample storing mechanism pair in one of the embodiments, It connects, or is docked with the output end of the sample conveying mechanism of another chemiluminescence detector;
The output end of the sample conveying mechanism can be with the sample conveyer of another chemiluminescence detector The input terminal of structure docks.
The chemiluminescence detector further includes consumption material box loading device in one of the embodiments, for passing automatically The defeated consumptive material the storage box for loading fluid suction head, and the consumptive material the storage box can also be delivered to and load position by the consumption material box loading device It sets;The sample charging mechanism loads the fluid suction head in the " loaded " position, and shifts sample by the fluid suction head.
It is separate to be located at the reaction vessel automatic conveying device for the consumption material box loading device in one of the embodiments, The buffering disc mechanism side, and the corresponding sample charging mechanism setting.
The chemiluminescence detector further includes pedestal in one of the embodiments, and the pedestal has carrying platform, The reaction unit, the measuring device, the cleaning device and the dispenser may be contained on the carrying platform.
The chemiluminescence detector further includes control device and fluid path device in one of the embodiments,;The control Device processed is electrically connected with the reaction unit, the measuring device, the cleaning device and the dispenser, the fluid path dress It sets and is connect with the dispenser;The pedestal has accommodating space, and the accommodating space is located at the lower section of the pedestal, described Control device and fluid path device are set in the accommodating space.
After adopting the above technical scheme, the beneficial effects of the utility model are:
The chemiluminescence detector of the utility model, when operation, sample is being transferred to buffering disc mechanism by dispenser In the reaction vessel;Then, reaction disc mechanism has added the reaction vessel of sample in carrying, and execute reagent adding, mixing and Incubate operation, the purged of impurities in cleaning device again of the reaction vessel after incubation, then by measuring device to determinand It is detected.After buffering disc mechanism is independently arranged, buffers disc mechanism and react disc mechanism independent operating, each section of process is mutual Operation can be carried out at the same time and there is no interference, efficiently solve when each section of process of current sample reaction executes and can Long operational time problem caused by holding time improves the detection speed of chemiluminescence detector, and then ensures detection efficiency.
Description of the drawings
Fig. 1 is the schematic top plan view of the chemiluminescence detector of one embodiment of the utility model;
Fig. 2 is the stereogram that disc mechanism is buffered in chemiluminescence detector shown in FIG. 1;
Fig. 3 is the side view of buffering disc mechanism shown in Fig. 2;
Wherein:
10- pedestals;
11- reagent storage means;
11- the first reagent storing mechanisms;
12- dispensers;
121- sample charging mechanisms;
122- pipetting devices;
13- reaction units;
131- buffers disc mechanism;
1311- buffers carrier;
13111- loading hole;
1312- buffers mounting structure;
13121- buffers chassis;
13122- damper leg components;
13123- cushioning supportive columns;
13124- buffers bearing block of usheing to seat;
1313- buffered-display driver structures;
13131- buffered-display driver motors;
13132- buffers transmission component;131321- buffers driving wheel;131322- buffer synchronisation bands;131323- buffering from Driving wheel;
13133- buffers swingle;
13134- buffers swivel bearing;
13135- buffers rolling bearing units;
1314- buffers detection structure;
13141- buffers induction pieces;
13142- buffering initialization detection pieces;
13143- buffers outer ring detection piece;
13144- buffers inner ring detection piece;
132- reacts outer disc mechanism;
Disc mechanism in 133- reactions;
14- cleaning devices;
15- measuring devices;
16- grabs cup device;
The new cups of 161- grab cup mechanism;
162- samples grab cup mechanism;
163- incubations grab cup mechanism;
Cup mechanism is grabbed in 164- cleanings;
Cup mechanism is grabbed in 165- measurements;
17- reaction vessel automatic conveying devices;
18- consumption material box loading devices;
19- sample conveying devices;
191- sample storing mechanisms;
192- sample conveying mechanisms;
20- reaction vessels.
Specific implementation mode
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, by the following examples, it and ties Attached drawing is closed, the chemiluminescence detector and its detection method of the utility model are further elaborated.It should be appreciated that this The described specific embodiment in place only to explain the utility model, is not used to limit the utility model.
It should be noted that being herein component institute serialization number itself, such as " first ", " second " etc., it is only used for distinguishing Described object does not have any sequence or art-recognized meanings.And " connection ", " connection " described in the application, unless otherwise instructed, Include directly or indirectly connecting (connection).In the description of the present invention, it should be understood that term "upper", "lower", The instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " clockwise ", " counterclockwise " Orientation or positional relationship be to be based on the orientation or positional relationship shown in the drawings, be merely for convenience of description the utility model and letter Change description, do not indicate or imply the indicated device or element must have a particular orientation, with specific azimuth configuration and Operation, therefore should not be understood as limiting the present invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature is "above" or "below" second feature Can be that the first and second features are in direct contact or the first and second features pass through intermediary mediate contact.Moreover, first is special Sign second feature " on ", " top " and " above " can be fisrt feature and be directly above or diagonally above the second feature, or only Indicate that fisrt feature level height is higher than second feature.Fisrt feature second feature " under ", " lower section " and " below " can be with It is that fisrt feature is directly under or diagonally below the second feature, or is merely representative of fisrt feature level height and is less than second feature.
Referring to Fig. 1, the utility model provides a kind of chemiluminescence detector, which can be to sample It is handled, and to treated, sample carries out analysis detection, obtains corresponding testing result, satisfies the use demand.It needs Bright, the specific type of sample to be measured is unrestricted, in some embodiments, sample to be measured include solid sample or Liquid sample.Further liquid sample includes but not limited to blood sample.The chemiluminescence detector of the utility model can Sample is set to be carried out respectively in different positions from the addition action of reagent, mixing action so that mutual operation will not be sent out Raw interference, while each operation can be carried out at the same time, and improve the detection speed of chemiluminescence detector, and then ensure detection effect Rate.
In the present invention, chemiluminescence detector includes reaction unit 13 and dispenser 12.Reaction unit 13 It is operated for carrying reaction vessel 20 and carrying out sample-adding sheet, reagent adding and incubate, the sample in such reaction vessel 20 and examination Agent can fully react, so that sample reaches best reaction condition, the detection of convenience sample parameter.Dispenser 12 is used for Sample or reagent are added in corresponding reaction vessel 20 by suction sample or reagent with realizing.
Moreover, chemiluminescence detector further includes cleaning device 14 and measuring device 15.Cleaning device 14 is for removing temperature The impurity in reaction vessel 20 after educating, measuring device 15 is for being detected the determinand in reaction vessel 20.It can manage Solution, reaction unit 13 can carry out incubation operation to the sample in reaction vessel 20 with reagent, that is, mixture so that sample It fully reacts and combines with reagent, and impurity then needs to be removed in reaction vessel 20, in order to avoid influence what measuring device 15 detected Accuracy.Therefore, the reaction vessel 20 of reaction unit 13 after incubation, by cleaning device 14 to the impurity in reaction vessel 20 Separation cleaning is carried out, to remove impurity in reaction vessel 20 so that leave determinand in reaction vessel 20;Then, measuring device 15 are again detected the determinand in reaction vessel 20, to obtain every detection parameters of sample.
Understanding to sample and each stage name of reagent for convenience, herein to the title of sample and reagent each stage It is described in detail:Sample in reaction vessel is known as mixture after being mixed with reagent, and reaction unit 13 can be in reaction vessel Mixture carries out incubation operation so that sample is fully reacted with reagent, at this point, the substance in reaction vessel is determinand and miscellaneous Matter.Wherein, mixture refers to that the ratio of the substance formed after sample is mixed with reagent and sample and reagent, concentration are unrelated, herein Referred to as mixture.Mixture after reaction is presented in a manner of determinand and impurity in the reaction vessel.Impurity can be inabundant The substance of reaction, or the side reaction product that side reaction generates occurs, can also be that other influences measuring device 15 detects Substance etc., or be above-mentioned at least two composition.Cleaning device 14 removes the impurity in reaction vessel, measures dress Determinand in 15 detection reaction vessels is set, to obtain the parameters of sample.
Further, chemiluminescence detector further includes grabbing cup device 16, grabs cup device 16 for realizing reaction vessel 20 It is shifted between reaction unit 13, cleaning device 14 and measuring device 15, so that reaction vessel 20 at various locations and executes The detection that automatically analyzes of sample is realized in corresponding operation, improves operating efficiency.
At runtime, reaction unit 13 carries reaction vessel 20 to chemiluminescence detector, and dispenser 12 draws sample simultaneously It is transferred in reaction vessel 20, dispenser 12 can also draw reagent in reagent storage means 11 and be transferred to reaction vessel 20 In;Then, reaction unit 13 carries out mixing operation to reaction vessel 20 so that and the mixture in reaction vessel 20 is uniformly mixed, Reaction unit 13 carries out incubation operation to the mixture in reaction vessel 20 after mixing so that sample is fully anti-with reagent It answers.It grabs cup device 16 reaction vessel 20 after reaction is transferred in cleaning device 14, removing reaction by cleaning device 14 holds Impurity in device 20.It after the completion of cleaning, grabs cup device 16 and reaction vessel 20 is transferred in measuring device 15 again, filled by measuring The determinand set in 15 pairs of reaction vessels 20 is detected, and to obtain every detection parameters of sample, is satisfied the use demand.
Specifically, reaction unit 13 includes for carrying reaction vessel 20 and the buffering disc mechanism of execution plus sample operations 131, and for carrying reaction vessel 20 and executing reagent adding and the reaction disc mechanism of incubation operation, buffer disc mechanism 131 With react disc mechanism independent operating.Empty reaction vessel 20 is transferred on buffering disc mechanism 131, and subsequent dispenser 12 can Sample is transferred in the reaction vessel 20 in 131 overhead of buffering disc mechanism.Adding the reaction vessel 20 of sample can be transferred to React disc mechanism on, then by dispenser 12 by agent transfer to reaction disc mechanism reaction vessel 20 in, then again to anti- It answers disc mechanism to execute mixing and incubates operation.Moreover, chemiluminescence detector also there is sample to grab cup mechanism 162, that is, grab cup There is device 16 sample to grab cup mechanism 162, and sample grabs cup mechanism 162 and corresponds to buffering disc mechanism 131 and reaction disc mechanism setting, uses It is transferred in reaction disc mechanism in by the reaction vessel 20 buffered on disc mechanism 131.Dispenser 12 adds the samples to buffering After in the reaction vessel 20 of disc mechanism 131, sample, which grabs cup mechanism 162, to be transferred to reaction by the reaction vessel 20 for adding sample In disc mechanism, and continues to execute reagent adding, mixing and incubate in reaction disc mechanism relaying and operate.
The buffering disc mechanism 131 of the utility model is independently of reaction disc mechanism setting so that adding during pattern detection Sample operations are separated with reagent adding and mixing operation.This is because:Individually addition sample time be more than reagent adding and The time of mixing operation etc. has executed reagent adding and has been grasped with mixing if buffering disc mechanism 131 is wholely set with disc mechanism is reacted It also needs to rotate after waiting adds sample after work, causes the sample process time long, and then influence chemiluminescence detector Efficiency.Therefore, the utility model separates the operation for buffering disc mechanism 131 with the operation for reacting disc mechanism, in this way, addition sample Operation buffering disc mechanism 131 on, add sample reaction vessel 20 be stored in buffering disc mechanism 131 on, when reaction tray machine After structure has executed mixing operation etc., adds sample without waiting for buffer disc and can postpone to shift on punched disc mechanism 131 and added Next operation is executed on the reaction vessel of complete sample to reaction disc mechanism, improves the speed of service of reaction disc mechanism, Jin Erti The speed of service of high entire chemiluminescence detector.
As a kind of embodiment, dispenser 12 includes sample charging mechanism 121;Chemiluminescence detector further includes being used for Convey the reaction vessel automatic conveying device 17 of reaction vessel 20;Reaction vessel automatic conveying device 17 and sample charging mechanism 121 In the side of buffering disc mechanism 131.Sample is transferred in the reaction vessel 20 of buffering disc mechanism 131 by sample charging mechanism 121.Reaction Container automatic conveying device 17, to realize the automatic conveying of reaction vessel, improves transfer efficiency for conveying reaction vessel 20.Instead Container automatic conveying device 17 is answered to be located at the side of buffering disc mechanism 131 with sample charging mechanism 121, in this way, grabbing cup device 16 will be anti- The reaction vessel 20 in container automatic conveying device 17 is answered to be transferred on buffering disc mechanism 131, sample charging mechanism 121 can be by sample It is transferred in reaction vessel 20, the path for grabbing 16 transfer reaction container 20 of cup device can be reduced in this way, improve reaction vessel 20 The speed of transfer;The speed of sample transfer can also be improved simultaneously, it is to be understood that and then improve the fortune of chemiluminescence detector Line efficiency.It is understood that sample charging mechanism 121 is arranged with 17 heteropleural of reaction vessel automatic conveying device, can avoid in this way The sample transfer operation of sample charging mechanism 121 with grab cup device 16 by 20 turns of reaction vessel in reaction vessel automatic conveying device 17 The process for moving on to buffering disc mechanism 131 interferes, and ensures the performance of chemiluminescence detector.
Certainly, in the other embodiment of utility model, reaction vessel automatic conveying device 17 can also be replaced, i.e., Reaction vessel automatic conveying device 17 is not used to convey reaction vessel 20, reaction vessel 20 can be placed directly into reaction unit 13 In.Preferably, the reaction vessel 20 that reaction vessel automatic conveying device 17 conveys is usually medical disposable material, certainly, reaction is held Device 20 can also be recovered recycling.Optionally, when reaction vessel 20 reuses, can not also reaction vessel be used to pass automatically Defeated device 17 conveys reaction vessel 20.It is understood that reaction vessel 20 refers to carrying and capable of carrying out pattern detection analysis Consumptive material, such as reaction cup, test tube, sample slide, sample tube.In the present embodiment, reaction vessel 20 refers to reaction cup, reaction Container automatic conveying device 17 usually transmits reaction vessel box, and arranged in column reaction vessel of embarking on journey is carried in reaction vessel box 20.Moreover, the shape of reaction vessel box is unrestricted in principle, can be rectangular, round or other shapes, as long as reaction is held There is ear on device box, reaction vessel automatic conveying device 17 is facilitated to transmit.
Specifically, reaction vessel automatic conveying device 17 includes reaction vessel storing mechanism and reaction vessel hoisting mechanism. Reaction vessel storing mechanism is used for loading and storing multiple reaction vessel boxes, and reaction vessel hoisting mechanism is anti-for storing and being promoted Container is answered, to realize the conveying of reaction vessel 20.Reaction vessel hoisting mechanism is located at the top of reaction vessel storing mechanism, instead Answer container storage mechanism that can convey reaction vessel box to reaction vessel hoisting mechanism, reaction vessel hoisting mechanism can pick up instead Container is answered to be promoted to secondary top layer.It is reacted moreover, reaction vessel storing mechanism can be transmitted respectively with reaction vessel hoisting mechanism Container.Reaction vessel hoisting mechanism and reaction vessel storing mechanism can independent operating, and parallel transmission reaction vessel respectively 20.In this way, after the reaction vessel box in reaction vessel storing mechanism is partly or entirely transported to reaction vessel hoisting mechanism, it can To load reaction vessel box into reaction vessel storing mechanism so that reaction vessel hoisting mechanism continuance lifting reaction vessel box, It realizes the continuous load of reaction vessel box, improves whole efficiency;Reaction vessel hoisting mechanism transmission reaction vessel is not interfered with also Box.Moreover, reaction vessel storing mechanism can also be docked and detach with reaction vessel hoisting mechanism, facilitates and stored to reaction vessel Reaction vessel box is loaded in mechanism.
Further, the reaction vessel box in reaction vessel storing mechanism is arranged using overlapped way, multiple reactions Container layering is supported in reaction vessel hoisting mechanism.The massive store of reaction vessel box can be realized in this way, maximized Reduction occupy instrument placement position so that reaction vessel automatic conveying device 17 it is compact-sized, then reduce chemistry hair The overall dimensions of optical detector.Optionally, overlapped way storage reaction container can also be used in reaction vessel hoisting mechanism.Specifically , reaction vessel storing mechanism includes the storage holding unit for storing transmission structure and being set on storage transmission structure, storage support The reaction vessel box that multiple stackings are placed is carried in the portion of rising, and drives storage holding unit to move up and down by depositing transmission structure, it is real The promotion of existing reaction vessel box.Optionally, storage transmission structure can using synchronous belt wheel structure and/or gear & rack structure etc. The structure for realizing elevating movement stores the power source of transmission structure using motor etc., and reaction vessel storing mechanism also uses frame Structure encloses the memory space for being set as reaction vessel box, is not described in detail one by one herein.Reaction vessel hoisting mechanism includes promoting transmission knot Structure and it is set to the multipair promotion holding unit being oppositely arranged promoted on transmission structure, carrying one is instead in each pair of promotions holding unit Container is answered, drives promotion holding unit to move up and down by promoting defeated structure, realizes the promotion of reaction vessel box.Optionally, The structure of rotary and lifting movement can be realized using synchronous belt wheel structure etc. by promoting transmission structure, store the power of transmission structure Using motor etc. and by the transmission of the realizations campaigns such as gear, synchronous band structure, reaction vessel hoisting mechanism also uses frame in source Structure encloses the room for promotion for being set as reaction vessel box, is not described in detail one by one herein.
Chemiluminescence detector grabs cup device 16 in 17 transmission of predeterminated position crawl reaction vessel automatic conveying device Reaction vessel 20 in reaction vessel box, specially:To predeterminated position transmit reaction vessel box when, reaction vessel hoisting mechanism to The reaction vessel box of secondary top layer is promoted the top layer to reaction vessel box hoisting mechanism by upper one layer of movement, and reaction vessel passes automatically The reaction vessel box of reaction vessel hoisting mechanism top layer is delivered to predeterminated position by defeated device 17 again.Exist in this way, grabbing cup device 16 Predeterminated position captures the reaction vessel 20 in reaction vessel box and is transferred in reaction unit 13.
Optionally, reaction vessel automatic conveying device 17 further includes delivery device.Delivery device is set to reaction vessel and carries It rises in mechanism, the reaction vessel box of reaction vessel hoisting mechanism top layer can be pushed to predeterminated position by delivery device.Pusher Structure is released reaction vessel box using the structure of the linear movement outputs such as sliding-rail sliding structure or synchronous band structure, and uses motor Deng as power source.
Again optionally, reaction vessel automatic conveying device 17 further includes reaction vessel recovering mechanism.Reaction vessel recycling machine Structure is located at the lower section of predeterminated position, and reaction vessel recovering mechanism can recycle predetermined position and use the reaction vessel box completed. Reaction vessel recovering mechanism is for realizing that the recycling of reaction vessel box and storage, the reaction vessel box after use can be conveyed Into reaction vessel recovering mechanism, the recycling and storage of reaction vessel box are realized.When stored in reaction vessel recovering mechanism it is full or After nonresident portion reaction vessel box, it can be taken out from the lower section of reaction vessel recovering mechanism, can realize reaction vessel box in this way Continuous recycling, it is easy to use.Reaction vessel recovering mechanism includes time recycled transmission structure and be set on recycling transmission structure It admits a child into a nursery school plate, recycling supporting plate can drive recycling supporting plate to move up and down for carrying reaction vessel box, recycling transmission structure, in turn Realize the recycling and storage of reaction vessel box.Preferably, recycling transmission structure is using energy such as gear & rack structure, synchronous band structures It enough realizes the structure of elevating movement, and power source is used as using motor etc..
Again optionally, reaction vessel automatic conveying device 17 further includes reaction vessel positioning blanking mechanism, and reaction vessel is fixed Position blanking mechanism is set to the top of reaction vessel recovering mechanism.Reaction vessel box on reaction vessel hoisting mechanism can be pushed away Mechanism is sent to push on reaction vessel positioning blanking mechanism.It grabs cup device 16 and captures reaction on reaction vessel positioning blanking mechanism Reaction vessel 20 in container, and be transferred in reaction unit 13 and carry out the operations such as sample-adding sheet, reagent.It is anti-after the completion of use It answers container 20 to position blanking mechanism by reaction vessel to fall in reaction vessel recovering mechanism.It is understood that reaction is held Device positioning blanking mechanism can facilitate the positioning of reaction vessel box simultaneously so that the position of reaction vessel box is fixed always, convenient Grab the reaction vessel 20 during cup device 16 takes out reaction vessel box at 20 blanking mechanism of reaction vessel.It is anti-in reaction vessel box After answering container 20 to be all removed, reaction vessel box will be recovered, and be fallen at this point, reaction vessel box can be positioned by reaction vessel Material mechanism falls and is stored in reaction vessel recovering mechanism, facilitates the recycling of reaction vessel box.Specifically, reaction vessel positions Blanking mechanism is opened or is closed the channel that falls of reaction vessel box by slide switch door, and when opening falls channel, reaction is held Device box is fallen in reaction vessel recovering mechanism;When closing falls channel, reaction vessel box can be located at reaction vessel positioning and fall Expect in mechanism;Also, reaction vessel, which positions blanking mechanism, has positioning element, and delivery device is by reaction vessel box from reaction vessel When the top layer of hoisting mechanism is pushed on reaction vessel positioning blanking mechanism, reaction vessel box can be abutted with positioning element, be protected Reaction vessel box accurate positioning is demonstrate,proved, the crawl of cup device 16 is conveniently grabbed.
Optionally, reaction vessel recovering mechanism includes the first reaction vessel recovering mechanism and is recycled positioned at the first reaction vessel The second reaction vessel recovering mechanism below mechanism, the second reaction vessel recovering mechanism can be with the first reaction vessel recovering mechanisms pair It connects and detaches.Reaction vessel automatic conveying device 17 further includes drawer mechanism, reaction vessel storing mechanism and the second reaction vessel Recovering mechanism is set in drawer mechanism, and drawer mechanism can drive reaction vessel storing mechanism and the second reaction vessel recycling machine Structure is extracted out and is pushed into relative to chemiluminescence detector.When drawer mechanism is extracted out, reaction vessel storing mechanism is carried with reaction vessel Organizational separation is risen, the second reaction vessel recovering mechanism is detached with the first reaction vessel recovering mechanism, at this time can be to reaction vessel Reaction vessel box is loaded in storing mechanism, can take out the reaction vessel box after use in the second reaction vessel recovering mechanism.It takes out When drawer mechanism is pushed into, reaction vessel storing mechanism is docked with reaction vessel hoisting mechanism, the second reaction vessel recovering mechanism and the One reaction vessel recovering mechanism docks, and reaction vessel storing mechanism can transmit reaction vessel box to reaction vessel hoisting mechanism, Second reaction vessel recovering mechanism can continue to recycling reaction vessel box.Specifically, drawer mechanism can be slided along sliding rail, and can Extraction and the push-in of drawer mechanism are automatically controlled by chemiluminescence detector;Manual type can also be used by the pumping of drawer mechanism Go out and is pushed into.
Further, chemiluminescence detector also there is new cup to grab cup mechanism 161, that is, grabs cup device 16 and grab cup including new cup Mechanism 161.New cup grabs cup mechanism 161 and corresponds to reaction vessel automatic conveying device 17 and the buffering setting of disc mechanism 131, and being used for will be anti- The reaction vessel 20 in container automatic conveying device 17 is answered to be transferred in buffering disc mechanism 131.It is understood that new cup grabs cup Mechanism 161 can position the reaction vessel 20 on blanking mechanism in crawl reaction vessel box in reaction vessel, and be transferred to buffering In disc mechanism 131, to carry out the operations such as sample-adding sheet, reagent adding.
Referring to Fig. 1 to Fig. 3, as a kind of embodiment, buffering disc mechanism 131 includes rotatable buffering carrier 1311, empty reaction vessel 20 is transferred on buffering carrier 1311, then, dispenses mechanism to 1311 overhead of buffering carrier Reaction vessel 20 in add sample;After the completion of adding sample, sample, which grabs cup mechanism 162, will buffer the reaction on carrier 1311 Container 20 is transferred in reaction disc mechanism, to carry out reagent adding, mixing and incubate to operate.
Further, buffering disc mechanism 131 further includes buffering mounting structure 1312 and connects with the buffering transmission of carrier 1311 The buffered-display driver structure 1313 connect.The driving of buffered-display driver structure 1313 buffering carrier 1311 is relative to buffering mounting structure 1312 Rotation buffers and multiple loading hole 13111 for placing response container 20 is arranged on carrier 1311.Buffer mounting structure 1312 It is fixed to play the role of carrying installation, to support buffered-display driver structure 1313 thereon.Buffered-display driver structure 1313 is that buffering is held The power source that load plate 1311 moves is rotated so that buffering carrier 1311 turns to accordingly with driving buffering carrier 1311 Position, and operation accordingly is executed as added cup, sample-adding originally and cup being taken to operate.
Further, buffering carrier 1311 is in the form of annular discs, can facilitate buffering 1311 rotary motion trace of carrier in this way Control, facilitates the position of other devices of chemiluminescence detector to be arranged, avoids interfering, while also ensuring buffering carrier The movement locus of loading hole 13111 is fixed on 1311, is facilitated and add cup, sample-adding originally and cup is taken to operate.Certainly, new in this practicality In the other embodiment of type, buffering carrier 1311 also can oval, quadrangle or other can carry reaction vessel 20 shape.Still further, multiple loading hole 13111 are radially arranged in rows on buffering carrier 1311.In this way The ordered arrangement on buffering carrier 1311 of loading hole 13111 is enabled to, can be realized in fixed position to loading hole 13111 Middle addition takes out reaction vessel 20 and adds sample into reaction vessel 20.Moreover, multiple loading hole 13111 are arranged in column After cloth, the loading hole 13111 of multiple equal radiuses along circumferential direction on the rounded distribution of line, and the loading of multiple circular distributions Hole 13111 is arranged around the center of circle of buffering carrier 1311 in concentric circles so that multiple loading hole 13111 are carried relative to buffering The center of circle of disk 1311 radially distributes.
Optionally, the quantity of two adjacent row loading hole 13111 is different, enables to cloth on buffering carrier 1311 in this way More loading hole 13111 are set, and then increase the addition quantity of reaction vessel 20, improve the sample-adding rate of reaction vessel 20, after And improve the detection rates of chemiluminescence detector.In the present embodiment, the quantity of each column loading hole 13111 is up to two, Minimum is one, that is to say, that wherein the quantity of a row loading hole 13111 is two, the number of an adjacent row loading hole 13111 Amount is one, and multiple loading hole 13111 is enabled to form outer ring and inner ring on buffering carrier 1311 in this way.Certainly, exist In the other embodiment of the utility model, loading hole 13111 also can be in that a circle is arranged.
Add cup position it is understood that buffering mounting structure 1312 has, add sample position and take a glass position.Buffering peace Adding cup position plus sample position and taking a glass position for assembling structure 1312 is fixed position, and adds cup position plus sample position And take cup to be positioned around buffering carrier 1311 and be arranged, the driving buffering carrier 1311 of buffered-display driver structure 1313 drives thereon Each loading hole 13111 moves to corresponding position.Add glass position to correspond to and grab the setting of cup device 16, new cup grabs cup mechanism 161 will Empty reaction vessel 20 is in adding the loading hole 13111 for being added at glass position and buffering carrier 1311;Load position, which corresponds to, to be added Model machine structure 121 is arranged, and sample charging mechanism 121 adds the samples to the reaction vessel 20 of buffering carrier 1311 at load position In;It takes a glass position to correspond to sample and grabs the setting of cup mechanism 162, sample, which grabs cup mechanism 162, will buffer carrier taking at glass position Reaction vessel 20 in 1311 takes out.
Specifically, the driving buffering carrier 1311 of buffered-display driver structure 1313 moves to plus cup position so that loading hole 13111 correspond to plus cup position, new cup grab cup mechanism 161 add glass position by reaction vessel 20 be loaded into buffering carrier 1311 it is right In the loading hole 13111 answered.The driving buffering carrier 1311 of buffered-display driver structure 1313 moves to plus sample position so that loads Reaction vessel 20 in hole 13111 corresponds to load position, and sample charging mechanism 121 adds the samples to buffering carrier in load position 1311 correspond in the reaction vessel 20 of loading hole 13111.The driving buffering carrier 1311 of buffered-display driver structure 1313, which moves to, to be taken Cup position so that the correspondence of reaction vessel 20 in loading hole 13111 takes a glass position, sample to grab cup mechanism 162 and a glass position is being taken to take Go out to buffer to have added the reaction vessel 20 of sample in carrier 1311.In the present embodiment, the loading hole on carrier 1311 is buffered 13111 can correspond to plus cup position plus sample position and take a glass position simultaneously, be performed simultaneously plus cup, sample-adding this and take cup to operate, The operational efficiency of buffering carrier 1311 can be improved in this way, and then improves the detection efficiency of complete machine.Certainly, in the utility model Other embodiment in, buffering carrier 1311 plus cup operation, plus sample operations and take cup operation can also sequentially carry out.
Specifically, buffering mounting structure 1312 includes damper leg component 13122 and buffering chassis 13121, damper leg Component 13122 be used to support buffering chassis 13121, will buffer chassis 13121 support certain altitude, facilitate carry out sample-adding with Cup is added to operate.Preferably, damper leg component 13122 is set on the table top of chemiluminescence detector.Buffered-display driver structure 1313 are installed on buffering chassis 13121.Buffered-display driver structure 1313 includes buffered-display driver motor 13131, buffering transmission component 13132 and buffering swingle 13133, buffered-display driver motor 13131 be fixed on buffering chassis 13121 on, buffered-display driver motor 13131 output end is connect with buffering transmission component 13132, and buffering transmission component 13132 also connects with buffering swingle 13133 It connects, buffering swingle 13133 is rotatably arranged on buffering chassis 13121, and buffers top and the buffering of swingle 13133 Carrier 1311 connects.The driving buffering transmission component 13132 of buffered-display driver motor 13131 moves so that buffering transmission component 13132 drive buffering swingle 13133 to rotate, and then buffer swingle 13133 and buffering carrier 1311 is driven to rotate, so that Buffering carrier 1311 moves to each position, and executes corresponding operation.
In the present embodiment, buffering transmission component 13132 include buffering driving wheel 131321, buffering driven wheel 131323 and Buffer synchronisation band 131322, buffering driving wheel 131321 are installed on the output end of buffered-display driver motor 13131, buffer driven wheel 131323 be sheathed on buffering swingle 13133 on, buffer synchronisation band 131322 be sheathed on buffering driving wheel 131321 with buffering from On driving wheel 131323.The driving buffering driving wheel 131321 of buffered-display driver motor 13131 rotates, and it is logical then to buffer driving wheel 131321 Crossing buffering synchronous belt 131322 drives buffering driven wheel 131323 to rotate so that buffering driven wheel 131323 drives buffering swingle 13133 rotations, and then buffer swingle 13133 and buffering carrier 1311 is driven to rotate.Preferably, buffered-display driver motor 13131 For stepper motor, and stepper motor is fine-tuning and included coding.Further, buffering driving wheel 131321 and buffering driven wheel 131323 diameter is different, to form certain reduction ratio, can improve buffering disc mechanism while increasing driving force in this way 131 kinematic accuracy during transmitting reaction vessel 20.Optionally, buffering driving wheel 131321 and buffering driven wheel 131323 Outer wall on also set up teeth portion, teeth portion can increase buffer synchronisation band 131322 and buffering driving wheel 131321 and buffering driven wheel Frictional force between 131323 avoids that slipping phenomenon occurs, ensures reliable transmission.Certainly, in other implementations of the utility model In mode, buffering transmission component 13132 also can be used gear engagement structure, chain drive structure etc. and directly drive buffering swingle The structure of 13133 rotations;Can be that buffered-display driver motor 13131 coordinates retarder and shaft coupling to directly drive buffering swingle The structure of 13133 rotations;It can also be the structure that direct driving motor structure directly buffers the rotation of swingle 13133.
Optionally, buffered-display driver structure 1313 further includes buffering swivel bearing 13134, and buffering swivel bearing 13134 is arranged On buffering chassis 13121, the rotary motion to ensure buffering swingle 13133 is steadily reliable.Buffered-display driver structure 1313 is also Including buffering rolling bearing units 13135, buffering mounting structure 1312 further includes buffering usher to seat bearing block 13124 and cushioning supportive column 13123, buffering rolling bearing units 13135 are sheathed on buffering swingle 13133, and buffering rolling bearing units 13135 are installed on buffer strip On seat bearing block 13124, buffers bearing block 13124 of usheing to seat and be supported on buffering chassis 13121 by cushioning supportive column 13123. Moreover, buffering rolling bearing units 13135 are located at the top of buffering swivel bearing 13134, buffering rolling bearing units 13135 support above Swingle 13133 is buffered, buffering swivel bearing 13134 buffers swingle 13133 in supported underneath so that buffering swingle 13133 even runnings.Preferably, the quantity of cushioning supportive column 13123 is three, and it is uniformly distributed, ensures that support is reliable.
Optionally, buffering disc mechanism 131 further includes buffering detection structure 1314, and buffering detection structure 1314 is set to buffering On mounting structure 1312.The setting of detection structure 1314 is buffered on buffering chassis 13121, for detecting buffering carrier 1311 State.It includes buffering induction pieces 13141, buffering initialization detection piece 13142, buffering outer ring detection piece to buffer detection structure 1314 13143 and buffering inner ring detection piece 13144.The periphery that induction pieces 13141 are mounted on buffering carrier 1311 is buffered, buffering is initial Change detection piece 13142, buffering outer ring detection piece 13143 and buffering inner ring detection piece 13144 and is installed in buffering chassis 13121 On, buffering initialization detection piece 13142 is mounted on the position that buffering chassis 13121 corresponds to the periphery of buffering carrier 1311, delays It rushes outer ring detection piece 13143 and is mounted on the position that buffering chassis 13121 corresponds to the outer ring of loading hole 13111 on buffering carrier 1311 It sets, buffering inner ring detection piece 13144 is mounted on buffering chassis 13121 and corresponds to the interior of loading hole 13111 on buffering carrier 1311 The position of circle.Buffering initialization detection piece 13142 buffers induction pieces 13141 by detection and determines the initial of buffering carrier 1311 Position.It whether there is in the loading hole 13111 of outer ring of the buffering outer ring detection piece 13143 for detecting buffering carrier 1311 Reaction vessel 20.In loading hole 13111 of the buffering inner ring detection piece 13144 for detect the inner ring for buffering carrier 1311 whether Existing reaction vessel 20.
It is understood that the initial position of the buffering initialization detection buffering carrier 1311 of detection piece 13142 is to pass through It controls buffered-display driver motor 13131 and operates realization, in this way, buffered-display driver motor 13131 is at initial position, Jin Ertong The position of buffering carrier 1311 can accurately be monitored by crossing the movement step number of buffering driving motor 13131 so that buffering carrying Disk 1311 moves accurately and reliably.In the present embodiment, buffering induction pieces 13141 are optocoupler sensing chip, buffering initialization detection piece 13142, buffering outer ring detection piece 13143 and buffering inner ring detection piece 13144 can be detection light coupling;Certainly, new in this practicality In the other embodiment of type, buffering induction pieces 13141, buffering initialization detection piece 13142, buffering outer ring detection piece 13143 To buffering inner ring detection piece 13144 can with Hall switch or other can realize the component of corresponding detection function.
When buffering the operation of disc mechanism 131, the buffering outer ring detection piece 13143 and buffering inner ring in detection structure 1314 are buffered Detection piece 13144 can detect loading hole 13111 vacant on buffering carrier 1311, the driving buffering of buffered-display driver structure 1313 The loading hole 13111 of the drive of carrier 1311 thereon turns to plus cup position, new cup grab cup mechanism 161 and pass reaction vessel automatically The hollow reaction vessel 20 of defeated device 17 is transferred in the loading hole 13111 in 1311 overhead of buffering carrier.Then, buffered-display driver The driving buffering carrier 1311 of structure 1313 turns to load position, and sample charging mechanism 121 adds sample into empty reaction vessel 20 This, completes sample-adding operation;The driving buffering carrier 1311 of buffered-display driver structure 1313 drives 20 turns of reaction vessel for adding sample It moves and takes a glass position.Sample grabs cup mechanism 162 and the reaction vessel 20 for buffering disc mechanism 131 is transferred in reaction disc mechanism, so The operations such as reagent adding are carried out afterwards.
Moreover, chemiluminescence detector, needs to execute initialization step after powering so that on buffering carrier 1311 not There are last time to operate remaining reaction vessel 20, can avoid sample contamination in this way, ensure the reliability of pattern detection;Meanwhile After buffering the initialization of disc mechanism 131, the placement location of the reaction vessel 20 recorded in chemiluminescence detector is all removed, instead Container 20 is answered to also ensure that new reaction vessel 20 is placed to the position of last time remaining reaction vessel 20 by all discardings, i.e., New reaction vessel 20 and last time remaining reaction vessel 20 is placed on same position, ensures the normal work of chemiluminescence detector Make.Therefore, chemiluminescence detector needs to carry out initialization operation after powering.When initialization operation, carrier 1311 is buffered On reaction vessel 20 all abandoned.Preferably, initialization operation can refer to chemiluminescence detector after a power failure again on The step of being executed after electricity.It should be noted that when being re-powered after chemiluminescence detector power down, buffered-display driver motor 13131 briefly return to initial position, and then, buffering carrier 1311 executes clear cup operation again.
It should be noted that the clear cup operation of buffering carrier 1311 is to grab cup mechanism 162 by sample to realize.Sample Cup mechanism 162 is grabbed with cup-shaped state and detecting state is grabbed, sample grabs cup mechanism 162 in transfer reaction container 20, and sample grabs cup Mechanism 162 is in and grabs cup-shaped state;Sample grabs cup mechanism 162 in clear cup, and sample grabs cup mechanism 162 and is in detecting state.Buffering For carrier 1311 when carrying out initialization operation, sample grabs the wherein one circle dress that cup mechanism 162 moves to buffering carrier 1311 It carries at hole 13111, sample grabs cup mechanism 162 and is in detecting state, at this point, control buffering 1311 quick rotation one of carrier circle. If sample grabs cup mechanism 162 and is able to detect that the signal with reaction vessel 20 in loading hole 13111, to the dress of the circle It carries hole 13111 to be detected one by one, if any reaction vessel 20, sample grabs cup mechanism 162 in cup-shaped state is grabbed, and captures reaction vessel The detection one by one that the circle carries out remaining loading hole 13111 is returned after 20 discardings;If it is quick in the circle that sample grabs cup mechanism 162 The signal of reaction vessel 20 is not detected when rotation, control sample, which grabs cup mechanism 162 and moves to next circle, similarly to be examined It surveys.And so on scanning and clear cup realize the clear cup operation of buffering carrier 1311;After the completion, buffering carrier 1311 can be with It places new reaction vessel 20 and carries out sample-adding operation.Sample grabs cup mechanism 162 and first passes through buffering carrier 1311 in clear cup soon Speed rotation is rotated by buffering carrier 1311 one by one again can save sweep time, improve clear cup efficiency.
As a kind of embodiment, chemiluminescence detector further includes the reagent storage means 11 for storing reagent, Reagent storage means 11 are located at the side of reaction disc mechanism.Reagent storage means 11 are used for storing reagent, can store sample inspection Required various reagents when survey facilitate the reagent needed for selection, improve the efficiency for drawing reagent.It is understood that reagent Storage device 11 can store plurality of reagents, and reagent storage means 11 also have cold storage function, the reagent for storing low temperature real The preservation of existing reagent.Dispenser 12 further includes pipetting device 122, and pipetting device 122 corresponds to reaction disc mechanism and reagent storage Device 11 be arranged, for will the agent transfer in reagent storage means 11 to reaction disc mechanism reaction vessel 20 in.
Further, it includes agent bin ontology and structure of controlling temperature that reagent storage, which loads, and agent bin ontology is used for storing reagent, Structure of controlling temperature is for controlling the intrinsic environment temperature of agent bin.Moreover, reagent by reagent storage container in agent bin ontology In embark on journey and arrange in column, pipetting device 122 is moved relative to agent bin ontology and is lifted on vertical plane in the horizontal plane Movement, realizes the absorption of reagent.Certainly, in the other embodiment of the utility model, reagent storing mechanism 111 can also be used Reagent disc carries reagent, drives reagent to turn to preset station by reagent carrier, pipetting device 122 is inhaled in default station Take reagent.
Specifically, structure of controlling temperature is set to the lower section of agent bin ontology, structure of controlling temperature is intrinsic for adjusting agent bin Environment temperature, so that the intrinsic environment temperature position of agent bin is between 2 DEG C -8 DEG C;Structure of controlling temperature includes cooling assembly and dissipates Hot-flow flue, heat dissipation wind channel include air duct box and wind turbine, and air duct box is set to the middle part of heat dissipation wind channel, and cooling assembly has heat dissipation Device, radiator are set in the inner cavity of air duct box, and wind turbine is set to air duct box under gas flow direction in heat dissipation wind channel Trip.The swabbing action of wind turbine can be utilized to accelerate the flowing of air in heat dissipation wind channel in this way, keep air-flow more stable;And radiator exists Forced heat-exchanging in closed cavity, further improves heat exchange efficiency.
Pipetting device 122 includes X-axis moving parts, Y-axis moving parts, Z axis moving parts and liquid relief component, X-axis movement Component, Y-axis moving parts and Z axis moving parts drive liquid relief component to do the movement of X-direction, the movement of Y direction and Z axis The movement in direction, so that liquid relief component, which can move in reagent storage means 11, draws reagent, moreover it is possible to move to reaction tray Reagent is added at mechanism.It is understood that X-axis moving parts, Y-axis moving parts and Z axis moving parts are all made of synchronous belt The transmission of the realizations campaign such as structure, and using motor as power source.Moreover, having reagent needle in liquid relief component, pass through reagent Needle is drawn or discharge reagent.Also, liquid relief component also uses the realization of the structures such as syringe or plunger pump quantitatively to draw reagent. Certainly, in the other embodiment of the utility model, pipetting device 122 can also be used rotating manner and liquid relief component drawn Reagent or addition reagent, at this point, pipetting device 122 is rotated using synchronous belt structure control liquid relief component.Further, chemical Luminometer further includes the reagent needle cleaning component of the reagent needle for cleaning pipetting device 122, and reagent needle cleaning component is set It is placed in reagent storing mechanism 111.After pipetting device 122 shifts a reagent, component is cleaned by reagent needle and is cleaned, with Avoid cross contamination.
Preferably, the reagent storage means 11 of the utility model are dispensed using including at least two reagent storing mechanisms 111 Device 12 includes sample charging mechanism 121 and at least two pipetting devices 122.In this way, each pipetting device 122 corresponds to an examination respectively Agent storing mechanism 111, pipetting device 122 by corresponding reagent storing mechanism 111 to be transferred to reaction disc mechanism corresponding anti- It answers in container 20.At runtime, corresponding reagent can be stored machine to chemiluminescence detector by least two pipetting devices 122 respectively Reagent in structure 111 transfering reagent into the reaction vessel 20 of reaction disc mechanism can be at least two pipetting devices 122 difference To in agent transfer at least two reaction vessels 20, can also be that at least two pipetting devices 122 add reagent on respectively In the same reaction vessel 20, it can also be that at least two pipetting devices 122 add reagent on reaction and hold several times or once In device 20.In such manner, it is possible to so that at least twice reagent adding operation be carried out at the same time or alternately, shorten the time of reagent adding, Greatly improve the operational efficiency of chemiluminescence detector.
Moreover, because different samples need to add different reagents in reaction, existed by least two pipetting devices 122 Addition reagent disclosure satisfy that the use demand of different samples on reaction disc mechanism.Each sample can be according to actual use demand selection One or both of which pipetting device 122 is added reagent operation.Pipetting device 122 can store machine in corresponding reagent Reagent is drawn in structure 111, and reagent is added in the corresponding position for being moved to reaction disc mechanism into reaction vessel 20.It is appreciated that , since pipetting device 122 needs the regular hour in reagent storing mechanism 111 with the movement reacted between disc mechanism, i.e., Pipetting device 122 is moved at reagent storing mechanism 111 after absorption reagent, then moves back to reaction disc mechanism addition reagent needs Time be respectively greater than operating time and the mixing operating time of transfer reaction container 20, at least two pipetting devices are set 122 cooperation operations can ensure to complete to draw reagent in one cycle and add reagent operation, and be executed to reaction vessel 20 Reagent adding operates.Here a cycle refers to the reaction tray mechanism kinematic primary time.Each step on disc mechanism is reacted in this way Rapid such as reagent adding, mixing take cup that can be carried out at the same time with cup operation is put, and can shorten the operating time of reaction disc mechanism, with The treatment effeciency of reaction disc mechanism is improved, and then improves the speed of service of complete machine.Optionally, at least two reagent storing mechanism 111 can be structure as a whole, and at least two pipetting devices 122 can select required reagent in reagent storing mechanism 111, and It is added in reaction vessel 20 in corresponding reagent adding station.In the present embodiment, the quantity of reagent storing mechanism 111 is two It is a, correspondingly, the quantity of pipetting device 122 is also two.
As a kind of embodiment, cleaning device 14 is used to remove the impurity in reaction vessel 20, to ensure to measure dress The accuracy of testing result when setting 15 detection determinand.Specifically, cleaning device 14 includes cleaning turntable, cleaning needle assemblies and suction Attachment.Multiple reaction vessels 20 are evenly spaced to be carried on the periphery of cleaning turntable.Adsorption piece is arranged in reaction vessel 20 The side of revolution track.Cleaning turntable rotates and reaction vessel 20 is driven to do revolution motion around the central axis of cleaning turntable, Under the action of adsorption piece, determinand can be attracted on the side wall of reaction vessel 20.When cleaning needle assemblies are cleaned, clearly Cleaning solution can be injected by washing needle assemblies, carry out separation cleaning to the mixture in reaction vessel 20 by cleaning solution, cleaning is completed Afterwards, cleaning needle assemblies can be adsorbed the waste liquid discharge in reaction vessel 20.
It is understood that the quantity of cleaning needle assemblies can be one or more groups of, with to the impurity in reaction vessel 20 Once cleaning is carried out, cleaned twice, cleaned even more be cleaned multiple times three times, the impurity in reaction vessel 20 is carried out at least once After cleaning, finally waste liquid is discharged by cleaning needle assemblies, determinand is left and measures or carry out secondary reagent adding operation.And And adsorption piece adsorbs determinand using such as magnet magnetic part, cleans needle assemblies and cleaning turntable using motor as power Source, and using the transmission of the realizations campaign such as gear transmission structure and/or toothed belt transmission structure.
Moreover, cleaning device 14 is located at the side of reaction disc mechanism.Reaction vessel 20 is in reaction disc mechanism and cleaning device When being shifted between 14, the path of the transfer of reaction vessel 20 can be reduced.Chemiluminescence detector also there is cleaning to grab cup mechanism 164, that is, it further includes that cup mechanism 164 is grabbed in cleaning to grab cup device 16, and cleaning grabs cup mechanism 164 and corresponds to cleaning device 14 and reaction tray machine Structure is arranged, for shifting reaction vessel 20 between reaction disc mechanism and cleaning device 14.That is, a glass machine is grabbed in cleaning Reaction vessel 20 after the completion of structure 164 can be educated disc mechanism medium temperature is reacted is transferred on the cleaning turntable of cleaning device 14;Clearly Washing to grab after the completion of cup mechanism 164 can also will clean need the reaction vessel 20 for adding reagent to be again transferred to reaction disc mechanism In.
As a kind of embodiment, measuring device 15 is for being detected the determinand in reaction vessel 20, to obtain To the corresponding detection parameters of sample.Specifically, measuring device 15 includes bottom plate, inner casing, shell, upper cover, measures turntable, driving machine Structure, the first substrate nozzle, the second substrate nozzle, photomultiplier detection components and waste suction liquid needle assemblies.Bottom plate, shell and upper cover The receiving space of measuring device 15 is surrounded, measures turntable, inner casing is located in receiving space, bottom plate, shell, inner casing, upper cover and survey It measures turntable and constitutes a darkroom.Measuring device 15 also have multiple reactor vessel processes stations, multiple reactor vessel processes stations it Between mutually every light seal.In the present invention, it is illustrated so that the quantity of reactor vessel processes station is four as an example.Four It is mutually sealed every light between reactor vessel processes station.When measurement:
First reactor vessel processes station (reaction vessel 20 enters station):Reaction vessel 20 is in the first reactor vessel processes It is placed into or takes out at station in measuring device 15;
(I station of excitation substrate is added) in second reactor vessel processes station:First substrate nozzle is set to the second reaction appearance Device is handled at station, excitation substrate I is added to reaction vessel 20;
Third reactor vessel processes station (reaction vessel 20 measures station):Second substrate nozzle, which is set to third reaction, to be held Device is handled at station, and excitation substrate II is added to reaction vessel 20, photomultiplier detection components are set to third reaction and hold Device is handled at station;
4th reactor vessel processes station (takes out waste liquid station):Waste suction liquid needle assemblies are set to the 4th reactor vessel processes work With the waste liquid of abstraction reaction container 20 at position.
First reactor vessel processes station, the second reactor vessel processes station, third reactor vessel processes station and the 4th Reactor vessel processes station is arranged in order and along turntable sense of rotation is measured mutually every light sealing, the first reactor vessel processes station Diagonally it is arranged with third reactor vessel processes station, the second reactor vessel processes station and the 4th reactor vessel processes station are diagonal Setting.Bottom plate, inner casing, shell, upper cover and measure turntable the processing of structure setting and each reactor vessel processes station function And its used mechanism is adapted.Driving mechanism measures turntable rotation for driving, and driving mechanism is using motor etc. as dynamic Power source, and using the transmission of the realization power such as gear drive motivation structure, turntable rotation is measured with driving.
Optionally, measuring device 15 further include every optical assembly, by separating each reactor vessel processes station every optical assembly, To ensure every optical property.Further, it is realized every light processing every the structure of light using light insulation pad or other realizations every optical assembly.
Moreover, measuring device 15 is located at the side of reaction disc mechanism, and it is disposed adjacent with cleaning device 14.Different samples There are difference, some samples directly to be measured after cleaning by measuring device 15 for the flow of processing, and some samples need It is then transferred to after cleaning in reaction unit 13 and carries out the operations such as secondary reagent adding, some samples are directly measured without cleaning. Therefore, measuring device 15 is located at the side for reacting disc mechanism with cleaning device 14, and measuring device 15 is adjacent with cleaning device 14 Setting can be shortened anti-when such reaction vessel 20 shifts between measuring device 15, cleaning device 14 and reaction disc mechanism The speed that reaction vessel 20 shifts is improved, and then improves the operational efficiency of chemiluminescence detector in the path for answering container 20 to shift. Chemiluminescence detector, which also has to measure, grabs cup mechanism 165, that is, it further includes measuring to grab cup mechanism 165 to grab cup device 16, and measurement is grabbed Cup mechanism 165 corresponds to cleaning device 14 and measuring device 15 is arranged, and is used for the reaction vessel 20 after being cleaned in cleaning device 14 It is transferred in measuring device 15.The reaction after being cleaned to impurity on turntable can will be cleaned that is, measuring and grabbing cup mechanism 165 Container 20 is transferred on the measurement turntable of measuring device 15, and turns over each reaction successively by measuring driven by rotary disc reaction vessel 20 Container processing station obtains the detection parameters of sample to be detected to the determinand in reaction vessel 20.
As a kind of embodiment, chemiluminescence detector further includes evenly mixing device, for adding in reaction unit 13 Then the progress mixing operation of reaction vessel 20 for adding sample and reagent carries out incubation operation again so that mixture is sufficiently mixed. Evenly mixing device is located at the side of reaction disc mechanism, can facilitate evenly mixing device in the reaction vessel 20 in reaction disc mechanism in this way Mixture carry out mixing operation.Specifically, evenly mixing device includes elevating movement mechanism and mixing mechanism, mixing mechanism is set to In elevating movement mechanism.Elevating movement mechanism can be such that mixing mechanism moves up and down so that mixing mechanism can hold with reacting The seamed edge of 20 short transverse of device is in contact, and subsequent mixing mechanism can drive the movement of reaction vessel 20 to make reaction vessel 20 by high speed Ground rocks, and ensures that sample is uniformly mixed with reagent, that is, mixture.It is understood that elevating movement mechanism is that can be lifted The rail structure of movement and/or synchronous band structure etc., mixing mechanism are that can realize the structure of eccentric rotary, also, lift Motion is with mixing mechanism using motor as power source.Certainly, in the other embodiment of the utility model, mixing dress The form that stirring rod can also be used is set to the mixture stirring in reaction vessel 20, realizes that mixture is uniformly mixed.
As a kind of embodiment, reaction disc mechanism include in independently operated reaction disc mechanism 133 with react external disk Mechanism 132 reacts outer disc mechanism 132 and accommodates reaction vessel 20 and execute reagent adding and mixing operation, and disc mechanism 133 holds in reaction Receive reaction vessel 20 and execute incubation operation.The reaction vessel 20 that sample is added on buffering disc mechanism 131 is transferred to outside reaction On disc mechanism 132, subsequent pipetting device 122 can hold agent transfer to the reaction for adding sample on outer disc mechanism 132 is reacted It in device 20, is then mixed with the reaction vessel 20 of reagent to adding sample so that mixture is uniformly mixed.After mixing Reaction vessel 20 be transferred in reaction in disc mechanism 133, and the mixture in reaction vessel 20 is incubated so that sample Reach best reaction condition, the luminescence detection apparatus of chemiluminescence detector is facilitated to detect sample parameter.
Preferably, buffering disc mechanism 131 is located at the side for reacting outer disc mechanism 132, reacts outer disc mechanism 132 and be sheathed on instead The outside of interior disc mechanism 133 is answered, can save the sky that reaction unit 13 occupies while facilitating reaction vessel 20 to shift in this way Between, to reduce the machine volume of chemiluminescence detector.Further, disc mechanism 133 is total in reacting outer disc mechanism 132 and react Axis is arranged, and can reduce the volume of reaction disc mechanism in this way, and then reduce machine volume.Certainly, the utility model other Outer disc mechanism 132 is reacted in embodiment is independently of the setting of disc mechanism 133 in reaction.Optionally, buffering disc mechanism 131 can With react in disc mechanism 133, the outer disc mechanism of reaction 132 be arranged layer by layer.Chemiluminescence detector, which also has to incubate, grabs cup mechanism 163, that is, it further includes incubating to grab cup mechanism 163 to grab cup device 16, incubation grab cup mechanism 163 correspond to react outer disc mechanism 132 with instead Interior disc mechanism 133 is answered to be arranged, for shifting reaction vessel 20 between disc mechanism 133 in reacting outer disc mechanism 132 and reacting.
Specifically, the outer disc mechanism 132 of reaction includes the reaction external disk carrier and drive response of carrying reaction vessel 20 The reaction external disk driving structure of external disk carrier rotation, reaction external disk driving structure is used as power source using motor etc., and passes through The transmission of the realizations campaign such as toothed belt transmission structure, the rotation of drive response external disk carrier.Disc mechanism 133 includes carrying in reaction The reaction inner disc driving structure of reaction inner disc carrier and drive response inner disc the carrier rotation of reaction vessel 20, in reaction Dish driving structure is used as power source using motor etc., and passes through the transmission of the realizations campaign such as toothed belt transmission structure, drive response Inner disc carrier rotates.Moreover, disc mechanism 133 also has heating structure and insulation construction in reaction, to reacting inner disc carrier In reaction vessel 20 heated, provide incubation environment for the reaction of mixture in reaction vessel 20, ensure mixture reaction It can be normally carried out, and then the detection that shines subsequently conveniently is carried out to sample.
Further, reacting outer disc mechanism 132 has multiple reaction stations, including adds a glass station, reagent adding station, mixing Station and incubation take a glass station.It should be noted that plus cup station, reagent adding station, mixing station and incubate take a glass work Around reaction external disk carrier setting, the fixed position of chemiluminescence detector adds a glass station, reagent adding station, mixing work for position Position and incubation take glass station not change with the rotation of reaction external disk carrier.Reacting external disk driving structure can Drive response external disk carrier drives reaction vessel 20 to turn to corresponding reaction station, and executes corresponding behaviour in reaction station Make.Preferably, the quantity of reagent adding station is two, two reagent storing mechanisms 111 and two pipetting devices are corresponded to respectively 122 settings, improve the efficiency of agent transfer, then improve the speed of service of instrument.
Add a glass station to correspond to sample and grab the setting of cup mechanism 162, sample is grabbed cup mechanism 162 and can will be buffered in carrier 1311 Reaction vessel 20 adding a glass station be placed into reaction external disk carrier in.Two reagent adding stations correspond to two reagents and deposit respectively It stores up mechanism 111 to be arranged, pipetting device 122 draws reagent in corresponding reagent storing mechanism 111, and in corresponding reagent adding station Place adds reagent in reaction vessel 20.Mixing station corresponds to evenly mixing device setting, and evenly mixing device can be incited somebody to action in mixing station React the mixture mixing in the reaction vessel 20 of external disk carrier.Incubation takes glass station to correspond to incubation and grabs the setting of cup mechanism 163, Incubation, which grabs cup mechanism 163, to incubate the reaction vessel 20 in taking glass station crawl reaction external disk carrier, and is transferred to anti- It answers in inner disc carrier.
It is understood that reaction external disk carrier drives reaction vessel 20 thereon to rotate corresponding station so that anti- Container 20 is answered to be performed corresponding operation in corresponding station, as reagent adding, mixing are operated with cup is taken;When reaction external disk carrier It turns to plus when cup station, sample grabs cup mechanism 162 and reaction vessel 20 is transferred to reaction external disk from buffering carrier 1311 In carrier.Two reagent adding stations are the first reagent adding station and the second reagent adding station.Further, add a glass station, First reagent adding station, the second reagent adding station, mixing station and incubation take glass station suitable relative to reaction external disk carrier Sequence is arranged.Illustrate the operation for reacting external disk carrier with the running orbit of a reaction vessel 20:Sample is grabbed cup mechanism 162 and is being added The reaction vessel 20 for adding sample is placed into reaction external disk carrier at cup station;Then, reaction external disk carrier drives Reaction vessel 20 is moved at the first reagent adding station and the second reagent adding station from glass station from adding, two pipetting devices 122 Reaction vessel 20 is added reagent on the first reagent adding station is corresponding at the second reagent adding station;Reagent is added to complete Afterwards, reaction external disk carrier drives reaction vessel 20 to be moved at mixing station from the second reagent adding station, and evenly mixing device exists The mixture in reaction vessel 20 is uniformly mixed at mixing station;After the completion of mixing, reaction external disk carrier drives reaction to hold Device 20 moves to incubation from mixing station and takes from glass station, and incubation is grabbed cup mechanism 163 and taken reaction vessel at glass station in incubation 20 take out, and are transferred in reaction inner disc carrier;Then, reaction external disk carrier, which returns, adds cup station, so recycles past It is multiple, realize continuous operation.
It should be noted that chemiluminescence detector in actual moving process, reacts outer 132 continuous operation of disc mechanism, I.e. reaction external disk carrier turns to adjacent station from a station after reaction external disk carrier operation a cycle, is adding cup While station adds reaction vessel to reaction external disk carrier, pipetting device is shifted in reagent adding station into reaction vessel The mixture of reaction vessel is uniformly mixed by reagent, evenly mixing device in mixing station, while incubation is grabbed cup mechanism 163 and taken in incubation Reaction vessel is transferred in reaction inner disc carrier by cup station.That is, after reaction external disk carrier rotation a cycle, It is performed simultaneously in corresponding station plus cup, reagent adding, mixing and cup is taken to operate.
Optionally, reaction station further includes that a glass station is put in cleaning, and cleaning puts that glass station is located at plus cup station is added an examination of with first Between agent station.Sample after the completion of disc mechanism incubates in reaction tray, which can be cleaned grabbing cup mechanism 164, is transferred to cleaning device 14 Middle carry out cleaning operation is carried out with washing the impurity in reaction vessel 20 since part sample also needs to secondary addition reagent Reaction, at this point, cup mechanism 164 is grabbed in cleaning to put a glass work in cleaning by the reaction vessel 20 after the completion of being cleaned in cleaning device 14 In bit transition to reaction external disk carrier.Also, sample after being incubated in disc mechanism 133 in reaction needs directly to carry out secondary When even repeatedly reagent adding operates, that is, the reaction vessel 20 after incubating just carries out secondary or multiple without the cleaning of cleaning device 14 Reagent adding operate, at this point, cleaning grab cup mechanism 164 can also by disc mechanism in reaction 133 incubate after reaction vessel 20 clear It washes to put a glass station and be transferred to and react in outer disc mechanism 133, the complete phase of subsequent process of subsequent process and the operation of a reagent adding Together, it does not repeat one by one herein.
Optionally, reaction external disk carrier relative to chemiluminescence detector also there is buffer station, buffer station to be located at Between two of arbitrary neighborhood reaction stations, buffer station can make adjacent two react stations and adjacent reaction station with Spacing between buffer station is equal.It is understood that buffer station is waiting station, reaction external disk carrier moves to slow It rushes at station, any operation is not carried out, can be that pending corresponding operating contributes the operating time in this way.
In the present embodiment, buffer station includes the first buffer station, the second buffer station and third buffer station, and adds cup Station, the first buffer station, cleaning are put a glass station, the second buffer station, the first reagent adding station, the second reagent adding station, are mixed Even station, incubation take glass station and third buffer station in the direction of the clock between circumferential direction of reaction external disk carrier etc. Away from being arranged.Reaction external disk driving structure drive response external disk carrier moves to above-mentioned reaction station and buffering work respectively Position, and execute corresponding operation.It should be noted that reaction external disk driving structure is per drive response external disk carrier rotation one Secondary, reaction external disk carrier is around 1/9 circle of its center of circle rotation so that the reaction vessel 20 on reaction external disk carrier can be right respectively Nine station settings are answered, and corresponding operation is executed by the device of corresponding station.Each station is using above-mentioned setting and coordinates phase After the operation structure answered, the working efficiency of reaction external disk carrier can be effectively improved so that react external disk carrier and its Process flow between his function module such as buffering carrier 1311, pipetting device 122, reaction inner disc carrier is more smoothly, Improve the operational efficiency of chemiluminescence detector.
It should be noted that new, cup grabs cup mechanism 161, sample grabs cup mechanism 162, incubates and grabs cup mechanism 163, cleans and grab cup Mechanism 164, measurement grab cup mechanism 165 may be used grab a glass drive component, grab glass control assembly and grab the realizations such as glass arm component it is anti- Answer the crawl and transfer of container 20.It is understood that grabbing glass control assembly may be used general control system such as controller Etc., it grabs a glass drive component and driving motor mate gear transmission component, V belt translation component or chain kit etc. may be used Realize the motion control for grabbing glass arm component, so as to grab a glass movement for arm component carry out level and vertical direction, a glass arm group is grabbed in guarantee Part moves in place and captures transfer reaction container 20.Moreover, the end for grabbing glass arm component has handgrip, is captured and reacted by handgrip Container 20.
As a kind of embodiment, chemiluminescence detector further includes sample conveying device 19, for conveying sample To sample position;Sample position is located at the side of buffering disc mechanism 131 and corresponding sample charging mechanism 121 is arranged;Sample charging mechanism 121 exists Sample position is drawn sample and is transferred in the reaction vessel 20 of buffering disc mechanism 131.Sample conveying device 19 is waited for for conveying Test sample sheet realizes the Automatic Conveying of sample to be tested, to improve sample introduction efficiency.Moreover, sample conveying device 19 conveys sample To sample position, sample charging mechanism 121 draws sample at sample position and is transferred to the reaction vessel 20 of buffering disc mechanism 131 In, the distance of sample transfer can be shortened in this way, improve sample transfer efficiency.
Specifically, sample conveying device 19 includes sample storing mechanism 191 and is detachably connected with sample storing mechanism 191 Sample conveying mechanism 192, store multiple sample racks for being mounted with sample, sample storing mechanism 191 in sample storing mechanism 191 Sample rack is transported in sample conveying mechanism 192, and sample position is delivered to by sample conveying mechanism 192.Sample conveying dress It further includes sample transfer device to set 19, and sample transfer device can make the sample rack in sample storing mechanism 191 be transferred to sample In conveying mechanism 192.Sample storing mechanism 191 has conveying mouth, and sample rack is transferred to sample transfer device by conveying mouth On, and sample rack is transferred on sample conveying mechanism 192 by sample transfer device.Sample conveying mechanism 192 includes track Component and become rail structure, sample transfer device can dock with the transmission channel of rail assembly, so that rail assembly is by sample It is transported to sample position.Rail assembly realizes the conveying of sample rack using synchronous band structure etc..Become rail structure and enables to sample Frame shifts between multiple transmission channels of rail assembly.Optionally, sample transfer device includes ferry-boat trolley, small by ferrying Vehicle realizes that sample storing mechanism 191 is connected to transmission channel.Certainly, sample transfer device can also be transfer orbit or crawl knot Structure etc. can realize the structure of sample rack transfer.Moreover, in the other embodiment of the utility model, sample conveying device 19 The mode that sample disk can also be used realizes the conveying of sample.
When 19 transmission sample of sample conveying device, the sample rack equipped with sample to be tested is put sample by operating personnel manually In storing mechanism 191;Sample storing mechanism 191 is mounted on chemiluminescence detection by connection structures such as support element and suspenders On the apparatus subject of instrument.Ferry-boat trolley chooses sample to be tested frame and delivers sample rack to the track groups of sample conveying mechanism 192 In the transmission channel of part, sample rack is transported to by sample position by rail assembly.After the completion of waiting for that sample charging mechanism 121 samples, become Rail structure changes the transmission channel for the sample rack that sampling finishes, and the sample rack that sampling finishes is transferred to sample structure for conveying Input terminal, and the sample rack that sampling finishes is transported in sample storing mechanism 191 by trolley of ferrying, operating personnel recycle sample The sample rack finished is sampled in this storing mechanism 191.
When more chemiluminescence detector splicings are in use, the input terminal of sample conveying mechanism 192 can be stored with sample Mechanism 191 is docked, or is docked with the output end of the sample conveying mechanism 192 of another chemiluminescence detector.Sample conveyer The output end of structure 192 can be docked with the input terminal of the sample conveying mechanism 192 of another chemiluminescence detector.That is, Sample storing mechanism 191 by a chemiluminescence detector is the sample conveying mechanism 192 of more chemiluminescence detectors Transmission sample realizes pile line operation.It is illustrated so that three chemiluminescence detectors splice as an example.First chemiluminescence is examined The input terminal for surveying the sample conveying mechanism 192 of instrument is docked with sample storing mechanism 191, the sample of First chemiluminescence detector The output end of conveying mechanism 192 is docked with the input terminal of second sample conveying mechanism 192, second sample conveying mechanism 192 Output end docked with the input terminal of third platform sample conveying mechanism 192.It is deposited by the sample of First chemiluminescence detector It is that three chemiluminescence detectors convey sample to store up mechanism 191.
As a kind of embodiment, sample charging mechanism 121 includes straight line slide unit, sample-adding module and hinged cantilever, is loaded mould Block is used for being loaded.Fluid suction head can be generally set in sample-adding module, to be sampled.In the utility model, sample-adding module is ADP modules.ADP modules:That is air-displacement pipetting module, Chinese are entitled:Pneumatic liquid relief module. In other embodiments, sample-adding module may be the sampling module being mainly made of draw point, fluid path and plunger pump.It is loaded module peace On hinged cantilever, sample-adding module is supported by hinged cantilever, while driving sample-adding module around the rotation of hinged cantilever Center rotating.Hinged cantilever is slidably mounted on straight line slide unit, drives hinged cantilever to move linearly by straight line slide unit.Specifically , straight line slide unit is sliding-rail sliding structure and/or synchronous band structure etc., to drive hinged cantilever to move in a straight line.In this way, straight line Slide unit coordinates with hinged cantilever so that being loaded module after sample position draws sample, and be transferred to the anti-of buffering disc mechanism 131 It answers in container 20.
Since the fluid suction head in sample-adding module is that medical disposable material needs to pass automatically to ensure the continuity of transfer sample Defeated fluid suction head.Therefore, chemiluminescence detector further includes consumption material box loading device 18, for transmitting the consumption for loading fluid suction head automatically Material the storage box, and consumptive material the storage box can also be delivered to " loaded " position by consumption material box loading device 18;Sample charging mechanism 121 is loading position Loading fluid suction head is set, and sample is shifted by fluid suction head.Fluid suction head is filled in consumptive material the storage box.Consumption material box loading device 18 includes Consumption material box accommodates storehouse, consumption material box surge bunker, consumption material box transport mechanism and consumption material box gripping body.Consumption material box transport mechanism is using same It walks band structure etc. and realizes the horizontal movement with vertical direction, so that consumptive material the storage box can be transferred to " loaded " position.Consumption material box Consumptive material the storage box can be accommodated in consumption material box and be passed between storehouse, consumption material box surge bunker and consumption material box transport mechanism by gripping body It send.In the present embodiment, fluid suction head is TIP heads, the TIP disposable tips for sampling.
Operating personnel are placed in consumption material box accommodates storehouse fill the consumptive material the storage box of fluid suction head manually, on consumption material box surge bunker Two buffering frames it is vacant.The consumptive material the storage box that consumption material box gripping body grips in a consumption material box receiving storehouse is placed on consumption material box On the delivery frame of transport mechanism, delivery frame transports consumptive material the storage box to " loaded " position, " loaded " position can to consumptive material the storage box into Luggage carries positioning so that the sample-adding module of sample charging mechanism 121 carries out fluid suction head loading in " loaded " position.Consumption material box gripping body presss from both sides After taking a consumptive material the storage box to place on delivery frame, then accommodates one consumptive material the storage box of crawl in storehouse from consumption material box and be placed on consumptive material In first buffering frame of box surge bunker.After waiting for that the fluid suction head in the consumptive material the storage box of " loaded " position is finished, delivery frame transports Empty consumptive material the storage box returns, and the empty consumptive material the storage box of consumption material box gripping body gripping is placed on second on consumption material box surge bunker In a buffering frame.After empty consumptive material the storage box is placed in second buffering frame on consumption material box surge bunker, consumption material box catching device Structure grips the consumptive material the storage box in first buffering frame and is placed on delivery frame, and delivery frame transports consumptive material the storage box.Consumption material box presss from both sides It takes mechanism to grip the empty consumptive material the storage box in second buffering frame to be placed on consumption material box receiving storehouse.Consumption material box gripping body presss from both sides One new consumptive material the storage box for filling fluid suction head of gripping from consumption material box receiving storehouse is taken to be placed on the first of consumption material box surge bunker In a buffering frame.The above action is repeated, realizes the continuous loading of consumptive material the storage box.It is understood that when empty consumptive material storage When box fills entire consumption material box receiving storehouse, consumption material box receiving storehouse can be directly extracted out, user takes empty consumptive material the storage box away, and Consumption material box, which accommodates, loads new consumptive material the storage box in storehouse.After the completion of loading, then consumption material box is accommodated into storehouse and is pushed into, consumption material box catching device Structure grips consumptive material the storage box again, and repeats aforesaid operations.Due to two buffering frames of setting, after extraction consumption material box accommodates storehouse, Instrument internal can also realize loading and the recycling of consumptive material the storage box, to realize continuous load.
Further, consumption material box loading device 18 is located at the separate buffering disc mechanism of reaction vessel automatic conveying device 17 131 side, and corresponding sample charging mechanism 121 is arranged.The transmission path of consumptive material the storage box can be shortened in this way, improve transmission effect Rate;It can also the space occupied is reduced, to reduce the machine volume of chemiluminescence detector.
As a kind of embodiment, chemiluminescence detector further includes pedestal 10, and pedestal 10 has carrying platform, reaction The carrying that device 13, measuring device 15, cleaning device 14, dispenser 12 and reagent storage means 11 may be contained within pedestal 10 is flat On platform.Reagent storage means 11, consumption material box loading device 18, sample conveying device 19 sample conveying mechanism 192 and sample deposit Storage mechanism 191 encloses the surrounding set on carrying platform respectively, and positioned at the marginal position of carrying platform.Reaction vessel transmits dress automatically 17 are set between consumption material box loading device 18 and the buffering disc mechanism 131 of reaction unit 12.As shown in Figure 1, reagent storage dress Two reagent storing mechanisms 111 for setting 11 are located at marginal position on front side of carrying platform, and consumption material box loading device 18 is located at carrying The marginal position of platform sinistral, sample storing mechanism 191 are located at the marginal position on the right side of carrying platform, sample conveying mechanism 192 Marginal position on rear side of carrying platform.Reaction disc mechanism is located at the central region of carrying platform, buffering disc mechanism 131, instead Container automatic conveying device 17, measuring device 15 and cleaning device 14 is answered to enclose set on the side of reaction disc mechanism;Sample charging mechanism 121 Between buffering disc mechanism 131 and sample delivery mechanism;Evenly mixing device, which is set to, to react on outer disc mechanism 132, and corresponding mixed Even station setting.Since the primary operational face of sample storing mechanism 191 is on right side, operating personnel are from right side to sample storing mechanism 191 sample loading framves, ferry-boat trolley take out sample rack from sample storing mechanism 191, and are sent into the conveying of the sample on rear side of instrument In mechanism 192, sample rack is transported to sample position, sample is drawn by sample charging mechanism 121.After the completion of absorption, sample rack again by Sample conveying mechanism 192 is sent back to through trolley of ferrying in sample storing mechanism 191, is taken out by operating personnel.
Further, chemiluminescence detector further includes control device and fluid path device;Control device and reaction unit 13, Measuring device 15, cleaning device 14, dispenser 12 and reagent storage means 11 are electrically connected, and fluid path device connects with dispenser 12 It connects;Also there is pedestal 10 accommodating space, accommodating space to be located at the lower section of carrying platform, and control device and fluid path device are set to appearance In between emptying.Control loads automatically controlling for each parts for being used for realizing chemiluminescence detector, so that each zero Part can realize automation mechanized operation, improve working efficiency.Fluid path device and pipetting device 122 and the main cleaning machine of cleaning device 14 Structure is connected to secondary wiper mechanism, and for pipetting device 122 and main wiper mechanism and secondary wiper mechanism provides cleaning solution or discharge is useless Liquid.
Moreover, being partly located at the top of carrying platform on reaction vessel automatic conveying device 17, it is flat that lower part is located at carrying In lower section, that is, accommodating space of platform.Specifically, drawer mechanism, reaction vessel storing mechanism and the second reaction vessel recovering mechanism It is set in accommodating space, reaction vessel hoisting mechanism and the first reaction vessel recovering mechanism are located above carrying platform.Work as pumping When drawer mechanism is extracted out, is loading reaction vessel box to reaction vessel storing mechanism and returned in the second reaction vessel recovering mechanism While receiving reaction vessel box, reaction vessel hoisting mechanism and the first reaction vessel recovering mechanism still are able to realize reaction vessel box Load and recycling, realize reaction vessel box it is continuous load with continuously recycle so that instrument being capable of normal operation.Carrying platform Reaction vessel hoisting mechanism and the first reaction vessel recovering mechanism can be supported, lock out operation when drawer mechanism being facilitated to extract out; Accommodating space can also accommodate drawer mechanism, reaction vessel storing mechanism and the second reaction vessel recovering mechanism so that close in space Reason utilizes, to ensure machine volume.
The utility model also provides a kind of detection method of chemiluminescence detector, which is based on above-described embodiment In chemiluminescence detector.Detection method includes the following steps:
It is loaded this step;Sample is transferred in reaction vessel 20;
Reagent adding step;It will be in agent transfer to reaction vessel 20;
Mixing step;Mixture in reaction vessel 20 is uniformly mixed;
Incubation step;Incubation operation is carried out to the mixture being uniformly mixed in reaction vessel 20;
Separation cleaning step;The impurity in reaction vessel 20 after removal incubation;
Measuring process;Determinand in reaction vessel 20 after cleaning is detected.
When to pattern detection, reaction vessel automatic conveying device 17 will react the chemiluminescence detector of the utility model Container is transferred in reaction vessel positioning blanking mechanism, and consumptive material the storage box is transported to and loads position by consumption material box loading device 18 It sets.Sample rack is transferred in sample storing mechanism 191 by sample conveying mechanism 192 by sample conveying device 19 inhales sample position It sets.Cup mechanism 161 is grabbed by new cup the reaction vessel 20 in reaction vessel box is transferred in buffering disc mechanism 131 in case using. The sample-adding module of sample charging mechanism 121 loads a new TIP head, and draws sample in sample position and be transferred to buffering disc mechanism In 131 one or more reaction vessel 20.Sample, which grabs cup mechanism 162, will buffer 20 turns of reaction vessel in disc mechanism 131 It moves on to and reacts in outer disc mechanism 132;Reaction external disk carrier drives reaction vessel 20 to move to reagent adding station, pipetting device 122 draw the reagent in reagent storing mechanisms 111 and are transferred in reaction vessel 20 in reagent adding station;React external disk carrier Reaction vessel 20 is driven to move to mixing station, evenly mixing device is driven reaction vessel 20 to be vibrated with fixed frequency, reacted with mixing Mixture in container 20.Reaction vessel 20 after mixing by incubation grab cup mechanism 163 be transferred in reaction in disc mechanism 133 into Row incubates operation so that sample is fully reacted with reagent.Reaction vessel 20 after the completion of incubation is grabbed cup mechanism 164 by cleaning and is shifted To cleaning operation is carried out in cleaning device 14, to remove the impurity in reaction vessel 20.Reaction vessel 20 after cleaning is by measuring It grabs cup mechanism 165 and is transferred in measuring device 15 and measure operation, the determinand in the reaction vessel 20 after cleaning is carried out Detection.
Detection method includes test sample method and system test method, and what above-mentioned detection method illustrated is test sample side Method below illustrates system detection method.System testing is divided into background measurement and optical test measures.Chemiluminescence detector When carrying out background measurement, it is sent into empty reaction vessel 20 into cleaning device 14, cup mechanism is grabbed by measurement after over cleaning 165 are transferred in measuring device 15, and measuring device 15 fills substrate solution to reaction vessel 20, measure background luminous value.Chemistry hair Optical detector is added into reaction vessel 20 in reaction unit 13 when carrying out optical test measurement and quantitative carries luminous mark The compound for remembering object, is transferred directly to without over cleaning in measuring device 15, and measuring device 15 fills substrate to reaction vessel 20 Liquid measures its luminous value.
Further, detection method further includes following steps:
Before separation cleaning step, the reagent adding step, mixing step and incubation step of at least one cycle are repeated Suddenly;And/or
Before measuring process, repeat the reagent adding step of at least one cycle, mixing step, incubation step and point From cleaning step.
It should be noted that chemiluminescence detector adds number when being detected to sample, according to reagent, it is divided into One-step method, two-step method, three-step approach, four step rule.One-step method adds a reagent, and two-step method adds reagent twice, three-step approach Reagent three times is added, four step rule adds four reagents.It is required for carrying out mixing and incubate to operate after addition reagent every time, and And before incubating operation, mixing operation can be carried out, can also be operated without mixing.
Also, cleaning operation can be carried out between the adjacent reagent of addition twice, cleaning operation can not also be carried out;When into When row cleaning operation, then grabbing cup mechanism 164 by cleaning, the disc mechanism 133 out of reaction is transferred to cleaning device 14 by reaction vessel 20 In cleaned, after the completion of cleaning, then cup mechanism 164 is grabbed by cleaning, reaction vessel 20 is transferred to reaction from cleaning device 14 The cleaning of outer disc mechanism 132 puts glass station and carries out subsequent reagent adding operation;When without cleaning operation, cup mechanism is grabbed in cleaning Reaction vessel 20 in disc mechanism in reaction 133 is directly transferred to and reacts the cleaning of outer disc mechanism 132 and put a glass station progress by 164 Subsequent reagent adding operation.Also, before measuring device 15 is detected the determinand in reaction vessel 20, it is necessary to pass through cleaning Device 14 carries out separation cleaning operation, to remove the impurity in reaction vessel 20, ensures that 15 testing result of measuring device accurately may be used It leans on.
In addition, part sample also needs to addition pretreating reagent when detecting, to ensure the accuracy of pattern detection result.This In pretreating reagent refer to the liquid added, solid or mixture etc. before formally addition reagent.Therefore, detection side Method further includes following steps:Before reagent adding step, pretreating reagent is transferred in reaction vessel 20.That is, detection Method further includes adding pretreating reagent step, also, pretreating reagent is stored in reagent storing mechanism, adds pretreating reagent operation by moving Liquid mechanism 122 realizes.After pipetting device 122 shifts pretreating reagent into reaction vessel 20, reacts outer disc mechanism 132 and drive reaction Reagent adding operation and follow-up corresponding operation are executed after one circle of the rotation of container 20 again.It should be noted that the outer disc mechanism of reaction 132 drive the reaction vessel 20 for adding pretreating reagent during rotating a circle, without mixing step and incubation step.
In the present invention, above-mentioned pattern detection process is only illustrated by taking three-step approach as an example.A kind of situation is:Hold to reaction After adding sample in device 20, after repeating and sequentially executing reagent adding step, mixing step and incubation step three times, to reaction vessel Impurity in 20 carries out separation cleaning operation, then measures operation to the determinand in reaction vessel 20 again.Another feelings Condition is:After adding sample into reaction vessel 20, repeats and sequence executes reagent adding step, mixing step, incubation step and divides Three times from cleaning step, operation then is measured to the determinand in reaction vessel 20 again.Another situation is:Hold to reaction After adding sample in device 20, after sequence executes reagent adding step, mixing step and incubation step, repeats and sequence executes additional examination Agent step, mixing step, incubation step and separation cleaning step twice, are then again surveyed the determinand in reaction vessel 20 Amount operation.
Still further, before measuring process, separation cleaning step to the impurity in the reaction vessel 20 after incubation into Separation cleaning operates row at least once.
That is, chemiluminescence detector is when to pattern detection, it can be to reaction vessel 20 before measuring process In impurity once clean, clean even more be cleaned multiple times twice, can ensure that the impurity in reaction vessel 20 is clear in this way Wash clean, and then ensure that measuring device 15 measures accurately.It is understood that above said cleaning twice refers to continuous wash two It is secondary.Continuous wash is twice, certainly, also capable of washing primary before measuring process.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, it is all considered to be the record scope of this specification.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed, But it should not be understood as limiting the scope of the patent of the utility model.It should be pointed out that for the common of this field For technical staff, without departing from the concept of the premise utility, various modifications and improvements can be made, these all belong to In the scope of protection of the utility model.Therefore, the protection domain of the utility model patent should be determined by the appended claims.

Claims (14)

1. a kind of chemiluminescence detector, which is characterized in that including:
Reaction unit is operated for carrying reaction vessel and carrying out sample-adding sheet, reagent adding and incubate;The reaction unit includes For carrying the reaction vessel and executing plus the buffering disc mechanism of sample operations, and for carrying the reaction vessel and holding Row reagent adding and the reaction disc mechanism for incubating operation, the buffering disc mechanism react disc mechanism independent operating with described;
Dispenser, for will be in sample and agent transfer to the reaction vessel;And
Sample grabs cup mechanism, for the reaction vessel in the buffering disc mechanism to be transferred in the reaction disc mechanism.
2. chemiluminescence detector according to claim 1, which is characterized in that the dispenser includes sample charging mechanism; The chemiluminescence detector further includes the reaction vessel automatic conveying device for conveying the reaction vessel;The reaction is held Device automatic conveying device is located at the side of the buffering disc mechanism with the sample charging mechanism;
The chemiluminescence detector also there is new cup to grab cup mechanism, and the new cup grabs cup mechanism, and to correspond to the reaction vessel automatic Transmitting device is arranged with the buffering disc mechanism, for turning the reaction vessel in the reaction vessel automatic conveying device The buffering disc mechanism is moved on to, sample is transferred in the reaction vessel of the buffering disc mechanism by the sample charging mechanism.
3. chemiluminescence detector according to claim 1, which is characterized in that the chemiluminescence detector further includes using In the reagent storage means of storing reagent, the reagent storage means are located at the side of the reaction disc mechanism;
The dispenser further includes pipetting device, and the pipetting device corresponds to the reaction disc mechanism and reagent storage dress Install, for will the agent transfer in the reagent storage means to it is described reaction disc mechanism the reaction vessel in.
4. chemiluminescence detector according to claim 1, which is characterized in that the chemiluminescence detector further includes clear Cleaning device, for removing the impurity in the reaction vessel;The cleaning device is located at the side of the reaction disc mechanism;
Also there is the chemiluminescence detector cleaning to grab cup mechanism, and the cleaning grabs cup mechanism and corresponds to the cleaning device and institute Reaction disc mechanism setting is stated, for shifting the reaction vessel between the reaction disc mechanism and the cleaning device.
5. chemiluminescence detector according to claim 4, which is characterized in that the chemiluminescence detector further includes surveying Device is measured, for being detected to the determinand in the reaction vessel;The measuring device is located at the reaction disc mechanism Side, and be disposed adjacent with the cleaning device;
The chemiluminescence detector, which also has to measure, grabs cup mechanism, and the measurement grabs cup mechanism and corresponds to the cleaning device and institute Measuring device setting is stated, for the reaction vessel after being cleaned in the cleaning device to be transferred in the measuring device.
6. chemiluminescence detector according to claim 1, which is characterized in that the reaction disc mechanism includes independent operating Reaction in disc mechanism with react outer disc mechanism, the outer disc mechanism of the reaction accommodate the reaction vessel simultaneously execute reagent adding with it is mixed Even operation, disc mechanism accommodates the reaction vessel and executes incubation operation in the reaction;
The chemiluminescence detector, which also has to incubate, grabs cup mechanism, and the incubation grabs cup mechanism and corresponds to disc mechanism in the reaction Outer disc mechanism setting is reacted with described, for disc mechanism to react outer disc mechanism with described in the reaction by the reaction vessel Between shift.
7. chemiluminescence detector according to claim 6, which is characterized in that the outer disc mechanism of the reaction is sheathed on described The outside of disc mechanism in reaction, the buffering disc mechanism are located at the side of the outer disc mechanism of the reaction, and the reaction external disk machine Structure setting coaxial with disc mechanism in the reaction.
8. chemiluminescence detector according to claim 1, which is characterized in that the chemiluminescence detector further includes sample This conveying device, for sample to be delivered to sample position;The sample position is located at the buffering side of disc mechanism and right The sample charging mechanism is answered to be arranged;The sample charging mechanism is drawn sample in sample position and is transferred to described in the buffering disc mechanism In reaction vessel.
9. chemiluminescence detector according to claim 8, which is characterized in that the sample conveying device includes that sample is deposited Storage mechanism and the sample conveying mechanism that is detachably connected with the sample storing mechanism store in the sample storing mechanism multiple It is mounted with the sample rack of sample, the sample rack is transported in the sample conveying mechanism by the sample storing mechanism, and by The sample conveying mechanism is delivered to the sample position.
10. chemiluminescence detector according to claim 9, which is characterized in that the input terminal of the sample conveying mechanism It can be docked with the sample storing mechanism, or defeated with the sample conveying mechanism of another chemiluminescence detector Outlet is docked;
The output end of the sample conveying mechanism can be with the sample conveying mechanism of another chemiluminescence detector Input terminal docks.
11. chemiluminescence detector according to claim 2, which is characterized in that the chemiluminescence detector further includes Consumption material box loading device, for automatically transmit load fluid suction head consumptive material the storage box, and the consumption material box loading device can also will The consumptive material the storage box is delivered to " loaded " position;The sample charging mechanism loads the fluid suction head in the " loaded " position, and passes through The fluid suction head shifts sample.
12. chemiluminescence detector according to claim 11, which is characterized in that the consumption material box loading device is located at institute State the side of the separate buffering disc mechanism of reaction vessel automatic conveying device, and the corresponding sample charging mechanism setting.
13. chemiluminescence detector according to claim 5, which is characterized in that the chemiluminescence detector further includes Pedestal, the pedestal have carrying platform, the reaction unit, the measuring device, the cleaning device and dispensing dress It sets and may be contained on the carrying platform.
14. chemiluminescence detector according to claim 13, which is characterized in that the chemiluminescence detector further includes Control device and fluid path device;The control device and the reaction unit, the measuring device, the cleaning device and described Dispenser is electrically connected, and the fluid path device is connect with the dispenser;The pedestal has accommodating space, the accommodating sky Between be located at the pedestal lower section, the control device and fluid path device are set in the accommodating space.
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