CN113504380A - Full-automatic chemiluminescence immunoassay analyzer - Google Patents
Full-automatic chemiluminescence immunoassay analyzer Download PDFInfo
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- CN113504380A CN113504380A CN202110661101.3A CN202110661101A CN113504380A CN 113504380 A CN113504380 A CN 113504380A CN 202110661101 A CN202110661101 A CN 202110661101A CN 113504380 A CN113504380 A CN 113504380A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
Abstract
The invention relates to a full-automatic chemiluminescence immunoassay analyzer, which comprises a reaction cup loading module, a transmission track module, a sample filling module, a reagent filling module, a reaction disc module, a magnetic separation disc module and a detection module, wherein after a sample needle is rotated to a sampling position of the transmission track module by the sample filling module, the sample needle is pricked into the liquid level for sampling, and after sampling is finished, the sample needle is lifted and rotated to the sampling position of the reaction disc module for sampling; and the reagent filling module quantitatively fills the reagent into the reaction cup of the reaction disk module for uniform mixing reaction, and after the reaction is finished, the reaction disk module transfers the reaction cup into the magnetic separation module to adsorb the components participating in the reaction on the wall of the reaction cup. Compared with the prior art, the full-automatic chemiluminescence immunoassay analyzer has the advantages of simple structure, convenient operation, small occupied space due to the reduction of the size of the whole analyzer, reduction of the production cost and the like.
Description
Technical Field
The invention relates to the technical field of medical detection and analysis equipment, in particular to a full-automatic chemiluminescence immunoassay analyzer.
Background
Chemiluminescence immunoassay (CLIA) is a detection and analysis technology combining chemiluminescence assay technology with high sensitivity and high specificity immunoreaction, is used for detecting and analyzing various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, medicaments and the like, is a latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay, has the advantages of high sensitivity, wide detection range, good marker stability and the like, and is a main detection method in the immunoassay field.
But the chemiluminescence immunoassay device in the prior art also has the following defects that (1) the traditional device has larger volume, complex structure and larger occupied space; (2) the chemical reaction is greatly influenced by the temperature, a certain constant temperature condition needs to be kept, and if the temperature cannot be kept constant well, the accuracy of the measurement result of an instrument is seriously influenced; (3) different module parts are different in cold and heat, energy loss is caused, and energy conservation and environmental protection are insufficient.
Patent application CN201810422789.8 discloses a novel full-automatic chemiluminescence immunoassay appearance, and it adopts the modularized design, including sample storage module, sample transport module, reagent needle arm module, sample needle arm module, cleaning module, reaction cup transport module to and measuring module, still include reaction disc and the whole integrated module of reagent dish, wherein, this integrated module is a whole, and is inside and outside two ring structures, inside and outside two ring structures in between inner ring and the outer ring still be provided with the semiconductor refrigeration piece, have small, the integrated level is high, energy-concerving and environment-protective advantage. However, the technology has no reaction cup loading module, the reaction cups need to be arranged in advance, the reaction cup transportation module has a complex structure, high failure rate and higher cost; and a sample transmission track is not provided, so that large-batch sample introduction can not be carried out.
Patent application CN201811204271.3 discloses a full-automatic chemiluminescence immunoassay analyzer, which comprises a sample conveying device, a reaction cup conveying device, a reagent conveying device, a reaction device and an optical detection device. The reaction device is used for placing the reaction cup and receiving the sample conveyed by the sample conveying device and the reagent conveyed by the reagent conveying device into the reaction cup. The reaction disc is provided with at least two circles of reaction cup tracks, and the same position of each reaction cup track is provided with a reaction cup accommodating cavity. The reaction disc of the analyzer is provided with at least two circles of reaction cup tracks, so that the number of the accommodated reaction cups is increased, and the detection requirements of large flux and high speed measurement in the prior art are met. This analysis appearance sample conveyor, reaction cup conveyor, reagent conveyor, reaction unit and optical detection device mutually support, and whole analysis appearance configuration optimization has improved detection speed. However, the technology has no reaction cup loading module, the reaction cups need to be arranged in advance, the reaction cup transportation module has a complex structure, high failure rate and higher cost.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the full-automatic chemiluminescence immunoassay analyzer which is simple in structure, convenient to operate, small in occupied area and high in detection precision.
The purpose of the invention can be realized by the following technical scheme: a full-automatic chemiluminescence immunoassay analyzer comprises a transmission track module, a reaction cup loading module, a sample filling module, a reagent filling module, a reaction disc module, a magnetic separation disc module and a detection module, wherein the transmission track module transmits a sample to a sampling position, waits for the sampling of a sample needle of the sample filling module, and recovers or transmits the sample to the next analyzer after the sampling is finished; the reagent filling module is used for storing reagents and transferring the reagents to the reaction disk module or the magnetic separation disk module; the reaction disk module transfers the reaction cup to a sample adding position and a reagent adding position, or transfers the reaction cup to the magnetic separation module, or transfers the reaction cup to the detection module;
after the sample injection module rotates the sample needle to the sampling position of the transmission track module, the sample needle is inserted into the liquid level for sampling, and after sampling is finished, the sample needle is lifted and rotated to the sampling position of the reaction disc module for sampling; and after the reaction is finished, the reaction disk module transfers the reaction cup to the magnetic separation module, adsorbs the components participating in the reaction on the wall of the reaction cup, and extracts the components not participating in the reaction, or transfers the reaction cup to the detection module by the reaction disk module, and the sample is analyzed and detected.
Further, the conveying track module comprises a conventional track, an emergency treatment track, a recovery track and a track changing track, wherein the conventional track or the emergency treatment track conveys the sample rack conveyed by the last unit to a sampling position to wait for a sample needle assembly to absorb a quantitative sample; and the sample rack which finishes sampling enters the recovery track to recover the sample rack through the orbital transfer track or directly enters the next analysis unit.
Furthermore, the reaction cup loading module comprises a cup arranging component and a cup distributing component, reaction cups are orderly arranged through the cup arranging component and then slide into the cup distributing component to wait for the grabbing of the first grabbing component.
Furthermore, the cup arranging assembly comprises a chain device and a slide way device, the chain device conveys the reaction cups in the funnel to one side of the slide way device in an inclined upward manner, the reaction cups slide to the slide way device through gravity, a sensor is arranged on the slide way device to detect the number of the reaction cups, and the chain device stops moving after a certain number of the reaction cups are reached.
Further, the sample filling module comprises a first hand grip assembly for transferring the reaction cups, a sample needle assembly for transferring the samples and a blending assembly, wherein the first hand grip assembly transfers the reaction cups of the cup separating assembly into the reaction tray or transfers the reaction cups from the reaction tray into the blending assembly;
furthermore, the sample needle assembly transfers the sample in the conventional track or the emergency track to a reaction cup in a reaction disc, and the sample needle rotates to a sample needle cleaning pool for cleaning after being filled, so that cross contamination is avoided; the sample needle assembly consists of a sample needle and a lifting and rotating mechanism, the lifting and rotating mechanism rotates the sample needle to a sampling position of the transmission rail module, the sample needle is inserted into the liquid level for sampling by means of a liquid level detection technology, after sampling is completed, the sample needle is lifted and rotated to a sampling position of the reaction disc, and the sample needle is lowered by a certain height for sampling.
The mixing component is used for mixing the reaction cups filled with the samples and the reagents uniformly so as to ensure that the reaction cups are fully fused for reaction. The mixing subassembly contains mixing drive division, axis of rotation and reaction glass holder, mixing drive division transmission connect in the axis of rotation, the reaction glass holder connect in the axis of rotation, reaction glass snatch to the reaction glass holder of mixing subassembly through first tongs subassembly after having filled sample and reagent, rotate through mixing drive division drive axis of rotation, drive the reaction glass holder and rotate, carry out the mixing with sample and reagent in the reaction glass.
Further, the reagent filling module comprises a reagent tray assembly for storing reagent and a reagent needle assembly for transferring reagent; the reagent tray assembly is used for providing temperature and space required by reagent storage; the reagent tray assembly consists of a reagent tray, a transmission mechanism and a semiconductor refrigerating sheet. The reagent tray is used for placing a reagent box, and the moving part enables the reagent tray to rotate through the transmission mechanism. The inner ring of the reagent disk also comprises a fixed gear disk, and when the reagent kit rotates on the reagent disk, the gear disk of the inner ring can drive the magnetic bead bottles on the reagent kit to rotate, so that the magnetic beads in the magnetic bead bottles can be kept in a uniformly mixed state; the semiconductor refrigeration piece is located the bottom of reagent dish, can make the inside temperature of reagent dish subassembly keep at lower temperature, does benefit to the storage of reagent, and the semiconductor refrigeration piece has small, and the integrated level is high, energy-concerving and environment-protective advantage.
The reagent needle assembly transfers the reagent in the reagent tray to the reaction cup in the reaction tray, and the reagent needle rotates to the reagent needle cleaning pool for cleaning after the reagent needle is filled, so that cross contamination is avoided. The reagent needle assembly consists of a reagent needle and a lifting and rotating mechanism, after the reagent needle is rotated to a reagent taking position above the reagent disk, the needle is inserted into a liquid level reagent by means of a liquid level detection technology, after reagent taking is completed, the reagent needle is lifted and rotated to a reagent adding position of the reaction disk, and reagent is added after the reagent needle is lowered by a certain height.
Furthermore, the reaction disc module comprises a reaction disc assembly and a second gripper assembly, wherein a reaction cup is arranged on the reaction disc assembly, and the reaction cup is transferred to a sample adding position, a reagent adding position or a position to be gripped by rotating the reaction disc assembly; the reaction disc assembly comprises reaction cup placing positions of three circles, namely an inner circle, a middle circle and an outer circle, a reaction disc is fixed on the reaction cup placing positions, a rotating mechanism is arranged below the reaction disc, and the reaction cups in the reaction disc are conveyed to a sample adding position in a rotating mode;
the bottom of the reaction disk is also provided with a temperature control device, and the temperature control device controls the internal temperature of the reaction cup. The second hand grip component transfers the reaction cup from the reaction disc to the magnetic separation module, or transfers the reaction cup to the detection disc, the incubation disc or the cup throwing opening to perform the cup throwing action. The second hand grip assembly is arranged between the reaction disc assembly and the magnetic separation module, and can move up and down and rotate to grip reaction cups in the reaction disc to the magnetic separation disc or grip reaction cups in the magnetic separation disc to the detection disc assembly until the reaction cups are discarded.
Further, the magnetic separation module comprises a liquid injection mechanism, a liquid suction mechanism and a rotating mechanism. The liquid injection mechanism is provided with 2-8 liquid injection needles (1 of which is filled with substrate liquid) which can perform linear lifting motion, and the liquid suction mechanism is provided with 1-6 liquid suction needles which can perform linear lifting motion. The magnetic separation disc of the rotating mechanism can rotate through the transmission shaft, the synchronous wheel, the synchronous belt and the driving part. After the reaction cup is incubated on the reaction disc, the reaction cup is grabbed to the magnetic separation module through the second gripper assembly and placed on the magnetic separation disc of the rotating mechanism, the magnetic separation disc is driven to the position below the liquid injection mechanism through the transmission shaft, the synchronizing wheel, the synchronizing belt and the driving part, cleaning liquid is injected through the liquid injection needle for cleaning, components participating in reaction in the reaction cup are adsorbed on the wall of the reaction cup through the permanent magnet, then the magnetic separation disc is continuously driven to the position below the liquid suction mechanism, and components not participating in reaction are extracted and separated through the liquid suction needle.
Further, the detection module is used for detecting the luminescence of the reaction cup after the substrate is filled. The detection module consists of a detection disc and a photoelectric tube, and the photoelectric tube is positioned on one side of the detection disc. The detection disc can rotate through the transmission shaft, the synchronous wheel, the synchronous belt and the driving part, and the detection disc is also provided with a heating device, so that the detection disc can be kept in a certain temperature range, and the influence of temperature on reading of the photoelectric tube is reduced; the photoelectric tube can convert the optical signal in the reaction cup into an electric signal, and the concentration value of the measured object of the sample can be reflected through certain calculation. The second hand grip component grips the reaction cup after the magnetic separation to the detection disc, and the detection disc reads the reaction cup.
Compared with the prior art, the invention has the following beneficial effects:
(1) the modular design, simple structure, convenient operation can also reduce whole machine size simultaneously and make occupation space little to reduction in production cost.
(2) The analyzer is provided with the heating belt at the position of the detection disc assembly, so that a reaction cup in the reaction disc keeps a certain constant temperature condition of chemical reaction, and the influence of temperature on the accuracy of a measurement result of the analyzer is reduced;
(3) but reaction cup loading module automatic loading reaction cup makes it more convenient to add the reaction cup, and arranges with the looks side of slide in the reason cup subassembly, has reduced the trouble of automatic row cup.
(4) The special magnet arrangement mode in the magnetic separation module reduces the magnetic bead loss rate in the experimental process. The magnetic separation module is of a four-stage cleaning structure and comprises a first-stage cleaning structure and a second-stage cleaning structure, wherein the first-stage cleaning structure comprises a first liquid injection level, 5 first magnetic bead adsorption levels and a liquid absorption level; the second-stage cleaning comprises a second liquid injection level, 5 second magnetic bead adsorption levels and a liquid absorption level; the third-order washing comprises a third liquid injection level, 5 third magnetic bead adsorption levels and a liquid absorption level; the fourth-order washing comprises a fourth liquid injection level, 5 fourth magnetic bead adsorption levels and a liquid absorption level. The magnets are distributed on the inner side of the reaction cup, and the same magnetic pole of the magnets faces the reaction cup at each stage (S pole faces the reaction cup in the figure, and N pole faces the reaction cup). Wherein the height distribution of the fourth-order cleaning magnets is sequentially reduced, so that the effective substances are adsorbed at the lower position of the reaction cup, and can fully react with the substrate after the substrate is filled at the substrate filling position.
Drawings
FIG. 1 is a top plan view of the upper layer of an analyzer according to the present invention;
FIG. 2 is a bottom elevation view of an analyzer of the present invention;
FIG. 3 is a top plan view of the lower layer of the analyzer of the present invention;
FIG. 4 is a bottom rear view of an analyzer according to the present invention;
FIG. 5 is a top view of the magnet distribution of the magnetic separation module of the present invention;
fig. 6 is a side view of a magnetic separation module of the present invention.
1 a cup sorting component, 101 a funnel, 102 a chain device, 103 a slide device, 2 a cup separating component, 3 a first gripper component, 4 a reaction plate component, 5 a sample needle component, 6 a reagent needle component, 7 a blending component, 8 a second gripper component, 9 a magnetic separation module, 901 first-stage cleaning, 9011 a first injection level, 9021 a first magnetic bead adsorption level and an absorption level, 902 second-stage cleaning, 9012 a second injection level, 9022 a second magnetic bead adsorption level and an absorption level, 903 third-stage cleaning, 9013 a third injection level, 9023 a third magnetic bead adsorption level and an absorption level, 904 a fourth-stage cleaning, 9014 a fourth injection level, 9024 a fourth magnetic bead adsorption level and an absorption level, 9015 a filling level, 10 a detection module, 1001 a photoelectric tube, 11 a reagent plate component, 12 a transmission track module, a conventional track, an emergency call track, a 1203 recovery track, 1204 a track changing track, 1202 a sample needle cleaning needle pool, 14 a reagent needle cleaning pool, 15 reagent code scanners, 16 refrigerant liquid storage tanks, 17 cup-losing mouths, SR07 substrate plunger pumps, an A instrument rack, 18 containers (first, 19 containers (second), 20 waste material boxes, 21 substrate placing positions, SR01 sample plunger pumps, SR02 reagent plunger pumps, 22 buffer containers, 23 pump valve assemblies and 24 electronic control modules.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terms first, second and the like in the description and in the claims of the present invention are used for distinguishing between different objects and not for describing a particular order.
Examples
The invention relates to a full-automatic chemiluminescence immunoassay analyzer which comprises a transmission track module, a reaction cup loading module, a sample filling module, a reagent filling module, a reaction disc module, a magnetic separation disc module, a detection module, a liquid path module and a system control module, as shown in figures 1-3.
Wherein the transfer rail module is located on the rear side of the instrument, on one side of the sample needle assembly. The transmission track module transmits the sample to a sampling position, waits for the sample needle of the sample filling module to sample, and can recover or transmit the sample to the next analyzer after sampling.
In this embodiment, the transport track module 12 includes a conventional track 1201, an emergency track 1202, a recovery track 1203, and a derailment track 1204. The conventional track 1201 can transport the conventional sample rack transferred from the previous unit (which may be a sample unit or an analysis unit) to a sampling position to wait for a sample needle assembly to suck a quantitative sample; the emergency track 1202 can transport the emergency sample rack transferred from the previous unit (which may be a sample unit or an analysis unit) to a sampling position to wait for a sample needle assembly to suck a quantitative sample; the sampled sample rack enters the recovery track 1203 for recovery of the sample rack through the orbital transfer track 1204, or directly enters the next analysis unit.
The reaction cup loading module comprises at least one cup arranging component and at least one cup separating component, and in the embodiment, the reaction cup loading module comprises a cup arranging component 1 and a cup separating component 2. The cup arranging assembly 1 comprises a chain device 102 and a slide device 103, and reaction cups in the funnel 101 can be orderly arranged through the chain device 102 and the slide device 103 in the cup arranging assembly 1, then slide into the cup separating assembly 2, and wait for the grabbing of the first grabbing component 3. Specifically, the chain device 102 transports the reaction cups in the hopper 101 obliquely upward to one side of the slide device, and the reaction cups slide down to the slide device 103 through gravity, the slide device 103 is provided with a sensor for detecting the number of the reaction cups, and the chain device 102 stops moving after a certain number of the reaction cups are detected.
The sample filling module comprises at least one first gripper assembly, at least one sample needle assembly and at least one blending assembly. In this embodiment, the sample filling module comprises a first gripper assembly 3 (which is a conventional robotic gripper) for transferring the cuvette, and a sample needle assembly 5 and a mixing assembly 7 for transferring the sample. The first hand grip component 3 transfers the reaction cups of the cup separating component 2 to the reaction disc, and also transfers the reaction cups from the reaction disc to the blending component 7.
Specifically, the sample needle assembly 5 is composed of a sample needle and a lifting and rotating mechanism, after the lifting and rotating mechanism rotates the sample needle to a sampling position of the transmission rail module, the sample needle is inserted into the liquid level for sampling by means of a liquid level detection technology, after sampling is completed, the sample needle is lifted and rotated to a sampling position of the reaction disc, and then the sample needle is lowered by a certain height for sampling. (in this embodiment, the sample needle of the sample needle assembly 5 is a sampling needle, one end of the sampling needle is disposed on the rotating shaft of the lifting and rotating mechanism and connected to the sample plunger pump SR01, and the sampling needle is rotated by the rotating shaft to be above the reaction cup on the reaction disk assembly 4). The sample needle assembly 5 can transfer the sample in the conventional track 1201 or the emergency track 1202 into a reaction cup in a reaction tray, and after the sample needle is filled, the sample needle is rotated into the sample needle cleaning pool 13 for cleaning, so that cross contamination is avoided.
The blending component 7 is used for blending the reaction cups filled with the samples and the reagents to ensure that the reaction cups are fully fused for reaction. Specifically, mixing subassembly 7 contains mixing drive division, axis of rotation and reaction glass holder, mixing drive division transmission connect in the axis of rotation, the reaction glass holder connect in the axis of rotation, reaction glass snatch to mixing subassembly's reaction glass holder in filling sample and reagent after, through first tongs subassembly, rotate through mixing drive division drive axis of rotation, drive the reaction glass holder and rotate, carry out the mixing with sample and reagent in the reaction glass.
The reagent filling module comprises a reagent disk assembly 11 for storing reagents and a reagent needle assembly 6 for transferring reagents (by means of a hard tube directly connected to a reagent plunger pump SR 02). The reagent tray assembly 11 comprises a reagent tray, a transmission mechanism and a semiconductor refrigerating sheet (in this embodiment, the bottom of the reagent tray assembly 11 is provided with a rotatable reagent tray, and the reagent tray is provided with 30 stations capable of placing reagent cups). The reagent tray is used for placing a reagent box, and the moving part enables the reagent tray to rotate through the transmission mechanism. The inner ring of the reagent disk also comprises a fixed gear disk, and when the reagent kit rotates on the reagent disk, the gear disk of the inner ring can drive the magnetic bead bottles on the reagent kit to rotate, so that the magnetic beads in the magnetic bead bottles can be kept in a uniformly mixed state; the semiconductor refrigeration piece is located the bottom of reagent dish, can make the inside temperature of reagent dish subassembly keep at lower temperature, does benefit to the storage of reagent, and the semiconductor refrigeration piece has small, and the integrated level is high, energy-concerving and environment-protective advantage. Thus, the reagent tray can provide the temperature and space required to store the reagent. The reagent disk assembly 11 is further provided with a reagent scanner 15 on one side thereof for recognizing information for reading a reagent cartridge in the reagent disk.
The reagent needle assembly 6 can transfer the reagent in the reagent tray into the reaction cup in the reaction tray. After the reagent needle is filled, the reagent needle is rotated into the reagent needle cleaning pool 14 for cleaning, so that cross contamination is avoided. Specifically, the reagent needle assembly 6 is composed of a reagent needle and a lifting and rotating mechanism, after the lifting and rotating mechanism rotates the reagent needle to a reagent taking position above the reagent tray, the needle is inserted into a liquid level reagent by means of a liquid level detection technology, after reagent taking is completed, the reagent needle is lifted and rotated to a reagent adding position of the reaction tray, and reagent is added after the reagent needle is lowered by a certain height.
The reaction disc module comprises a reaction disc assembly 4 and a second gripper assembly 8, the reaction disc assembly 4 comprises reaction cup placing positions of three circles, namely an inner circle, a middle circle and an outer circle, a reaction disc is fixed on the reaction cup placing positions, and a rotating mechanism is arranged below the reaction disc and used for rotationally conveying the reaction cups in the reaction disc to a sample adding position; the bottom of the reaction disc is also provided with a temperature control device, the temperature control device controls the internal temperature of the reaction cup, the reaction disc component 4 provides a stable temperature environment for the reaction cup, and the reaction cup can be transferred to a sample adding position, a sample adding position and a position to be grabbed by means of rotating the reaction disc. Second tongs subassembly 8 (for conventional arm tongs), between reaction dish subassembly 4 and magnetic separation module, but second tongs subassembly 8 elevating movement and rotary motion can transfer the reaction cup from the reaction dish to magnetic separation module 9 in, also can transfer to the mouth of placing of detection dish, incubate dish and lose a rim of a cup 17 and lose a cup action.
As shown in fig. 2, the analyzer rack a of the analyzer is in a box shape, and has a container (18) and a container (19) for storing washing solutions, respectively, and a waste box (20) for storing reaction cups discarded by the cup discarding opening (17), a substrate placing position (21) for placing a substrate solution, the substrate solution being connected to the injection needle of the magnetic separation module through a substrate plunger pump SR07, a sample plunger pump SR01 connected to the sample needle for sucking and filling a sample into the sample needle assembly (5), and a reagent plunger pump SR02 connected to the reagent needle for sucking and filling a reagent into the reagent needle assembly (6).
The magnetic separation module comprises a liquid injection mechanism, a liquid suction mechanism and a rotating mechanism. The liquid injection mechanism is provided with 2-8 liquid injection needles (5 liquid injection needles in the embodiment, wherein 1 needle is filled with substrate liquid) and can perform linear lifting motion, and the liquid suction mechanism is provided with 1-6 liquid suction needles (4 liquid suction needles in the embodiment) and also can perform linear lifting motion. The magnetic separation disc of the rotating mechanism can rotate through the transmission shaft, the synchronous wheel, the synchronous belt and the driving part. After the reaction cup is incubated on the reaction disc, the reaction cup is grabbed to the magnetic separation module through the second gripper assembly and placed on the magnetic separation disc of the rotating mechanism, the magnetic separation disc is driven to the position below the liquid injection mechanism through the transmission shaft, the synchronizing wheel, the synchronizing belt and the driving part, cleaning liquid is injected through the liquid injection needle for cleaning, components participating in reaction in the reaction cup are adsorbed on the wall of the reaction cup through the permanent magnet, then the magnetic separation disc is continuously driven to the position below the liquid suction mechanism, and components not participating in reaction are extracted and separated through the liquid suction needle. The magnetic separation disc module 9 can adopt a four-stage cleaning scheme for cleaning the reaction cup, irrelevant impurities are cleaned, then substrate liquid is added, and the reaction cup rotates to a position to be grabbed to wait for the second gripper assembly to grab.
As shown in fig. 5-6, the magnetic separation module 9 is a four-stage cleaning structure, wherein the first-stage cleaning module 901 includes a first liquid injection position 9011, 5 first magnetic bead adsorption positions, and a liquid absorption position 9021; the second-stage washing 902 includes a second injection site 9012, 5 second magnetic bead adsorption sites, and a liquid absorption site 9022; the third-stage washing 903 comprises a third liquid injection position 9013, 5 third magnetic bead adsorption positions and a liquid absorption position 9023; the fourth step of washing 904 comprises a fourth injection site 9014, 5 fourth magnetic bead adsorption sites and a pipetting site 9024. The magnets are distributed on the inner side of the reaction cup, and the same magnetic pole of the magnets faces the reaction cup at each stage (S pole faces the reaction cup in the figure, and N pole faces the reaction cup). Wherein the height distribution of the magnets of the fourth-stage cleaning 904 is sequentially reduced, so that the effective substances are adsorbed at the lower position of the reaction cup and can fully react with the substrate after the substrate is filled at the substrate filling position 9015. The magnetic separation module adopts the special magnet arrangement mode, and the magnetic bead loss rate in the experimental process is reduced.
The detection module 10 is used for detecting the luminescence of the reaction cup after the filling of the substrate is finished. The detection module 10 consists of a detection disc and a photoelectric tube 1001, wherein the photoelectric tube 1001 is positioned on one side of the detection disc and is used for luminescence detection of a reaction cup after the filling of a substrate is finished, the detection disc can rotate through a transmission shaft, a synchronous wheel, a synchronous belt and a driving part, and the detection disc is also provided with a heating device, so that the detection disc can be kept in a certain temperature range, and the influence of the temperature on the reading value of the photoelectric tube is reduced; the photoelectric tube can convert the optical signal in the reaction cup into an electric signal, and the concentration value of the measured object of the sample can be reflected through certain calculation. The second hand grip component grips the reaction cup after the magnetic separation to the detection disc, and the detection disc reads the reaction cup.
The full-automatic chemiluminescence immunoassay analyzer is also provided with a refrigerating fluid storage tank 16 for storing refrigerating fluid. And the buffer container 22 is used for storing cleaning fluid, so that the influence of bubbles entering a pipeline in the process of replacing the container I18 or the container II 19 on the test result is avoided in the using process of the instrument.
The full-automatic chemiluminescence immunoassay analyzer also comprises an electric control module 24, wherein the electric control module is used for providing power supply required by the operation of the analyzer and transmitting control signals, so that the analyzer always keeps stable operation. As shown in fig. 3, the electronic control module 24 is disposed on the lower layer side of the analyzer and connected to each pump valve assembly 23 to control the opening and closing of each fluid path in the fluid path module.
Each part executes the steps according to the arrangement mode of the parts, so that the full-automatic chemiluminescence immunoassay analyzer is simple in structure and convenient to operate, and meanwhile, the size of the whole analyzer can be reduced, so that the occupied space is small, and the production cost is reduced.
Claims (10)
1. A full-automatic chemiluminescence immunoassay analyzer is characterized by comprising a transmission track module, a reaction cup loading module, a sample filling module, a reagent filling module, a reaction disc module, a magnetic separation disc module and a detection module, wherein after a sample needle is rotated to a sampling position of the transmission track module by the sample filling module, the sample needle is pricked into a liquid level for sampling, and after sampling is completed, the sample needle is lifted and rotated to the sampling position of the reaction disc module for sampling; and after the reaction is finished, the reaction disk module transfers the reaction cup to the magnetic separation module, adsorbs the components participating in the reaction on the wall of the reaction cup, and extracts the components not participating in the reaction, or transfers the reaction cup to the detection module by the reaction disk module, and the sample is analyzed and detected.
2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the transportation rail module comprises a conventional rail, an emergency treatment rail, a recycling rail and an orbital transfer rail, the conventional rail or the emergency treatment rail transports the sample rack transported from the previous unit to a sampling position, and waits for a sample needle assembly to suck a quantitative sample; and the sample rack which finishes sampling enters the recovery track to recover the sample rack through the orbital transfer track or directly enters the next analysis unit.
3. The automated chemiluminescent immunoassay analyzer of claim 1 wherein the cuvette loading module comprises a cuvette sorting module and a cuvette dividing module, wherein the cuvettes are arranged in order by the cuvette sorting module and then slide into the cuvette dividing module to wait for the first gripper module to grasp.
4. The automated chemiluminescent immunoassay analyzer of claim 3 wherein the cup sorting assembly comprises a chain assembly and a slide assembly, wherein the chain assembly transports the cuvettes in the funnel obliquely upward to one side of the slide assembly and slides down to the slide assembly via gravity, the slide assembly has a sensor to detect the number of cuvettes, and the chain assembly stops after a certain number of cuvettes have been detected.
5. The full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein the sample filling module comprises a first hand grip assembly for transferring the reaction cup, a sample needle assembly for transferring the sample and a mixing assembly, wherein the first hand grip assembly transfers the reaction cup of the cup dividing assembly to the reaction tray or transfers the reaction cup from the reaction tray to the mixing assembly; the sample needle assembly transfers a sample in a conventional track or an emergency track to a reaction cup in a reaction disc, and the sample needle rotates to a sample needle cleaning pool for cleaning after the sample needle is filled, so that cross contamination is avoided; the mixing component is used for mixing the reaction cups filled with the samples and the reagents uniformly so as to ensure that the reaction cups are fully fused for reaction.
6. The automated chemiluminescent immunoassay analyzer of claim 1 wherein the reagent filling module comprises a reagent tray assembly for storing reagents and a reagent needle assembly for transferring reagents; the reagent tray assembly is used for providing temperature and space required by reagent storage;
the reagent needle assembly transfers the reagent in the reagent tray to the reaction cup in the reaction tray, and the reagent needle rotates to the reagent needle cleaning pool for cleaning after the reagent needle is filled, so that cross contamination is avoided.
7. The full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein the reaction disc module comprises a reaction disc assembly and a second gripper assembly, a reaction cup is arranged on the reaction disc assembly, and the reaction cup is transferred to a sample adding position, a reagent adding position or a position to be gripped by rotating the reaction disc assembly;
the second hand grip component transfers the reaction cup from the reaction disc to the magnetic separation module, or transfers the reaction cup to the detection disc, the incubation disc or the cup throwing opening to perform the cup throwing action.
8. The full-automatic chemiluminescence immunoassay analyzer according to claim 7, wherein the reaction tray assembly comprises three circles of reaction cup placement positions, namely, a reaction tray is fixed on the reaction cup placement positions, a rotating mechanism is arranged below the reaction tray, and the reaction cups in the reaction tray are rotationally conveyed to a sample adding position;
the bottom of the reaction disk is also provided with a temperature control device, and the temperature control device controls the internal temperature of the reaction cup.
9. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the magnetic separation disk module comprises a liquid injection mechanism, a liquid suction mechanism and a rotating mechanism; the liquid injection mechanism is provided with 2-8 liquid injection needles which can perform linear lifting motion, and the liquid suction mechanism is provided with 1-6 liquid suction needles which can perform linear lifting motion; the magnetic separation disc of the rotating mechanism performs rotary motion through a transmission shaft, a synchronous wheel, a synchronous belt and a driving part.
10. The automated chemiluminescent immunoassay analyzer of claim 1 wherein the detection module is adapted for luminescence detection of the reaction cuvette after filling of the substrate.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114113048A (en) * | 2021-11-23 | 2022-03-01 | 南京晶捷生物科技有限公司 | Optical detection equipment |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
| CN114384063A (en) * | 2022-03-23 | 2022-04-22 | 深圳天辰医疗科技有限公司 | Chemiluminescence apparatus |
| CN114660317A (en) * | 2022-02-10 | 2022-06-24 | 北京胡曼智造科技有限责任公司 | Flow type fluorescence luminescence immunoassay instrument |
| CN114965886A (en) * | 2022-05-18 | 2022-08-30 | 深圳无疆生命科学有限公司 | Sample adding disc device and sample analyzer |
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Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050042138A1 (en) * | 2003-08-20 | 2005-02-24 | Sysmex Corporation | Sample analyzer, nucleic acid detector and nucleic acid detection method |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
| CN204953107U (en) * | 2015-09-02 | 2016-01-13 | 苏州长光华医生物医学工程有限公司 | Reactant washs device of separation in chemiluminescent immunoassay luminesceence analysis appearance |
| CN107144689A (en) * | 2017-06-28 | 2017-09-08 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer magnetic cleaning separating mechanism of magnet one side arrangement |
| CN107966579A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | One kind has biochemistry, enzyme is exempted from and chemiluminescence rapid detection system and method |
| CN207816996U (en) * | 2017-09-20 | 2018-09-04 | 深圳迈瑞生物医疗电子股份有限公司 | A kind of automatic analysing apparatus |
| CN109433686A (en) * | 2018-12-27 | 2019-03-08 | 上海奥普生物医药有限公司 | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter |
| CN109917145A (en) * | 2017-12-12 | 2019-06-21 | 深圳拓真生物科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN110672835A (en) * | 2019-09-26 | 2020-01-10 | 合肥运涛光电科技有限公司 | Magnetic separation mechanism for chemiluminescence immunoassay system |
| CN210090481U (en) * | 2019-05-31 | 2020-02-18 | 艾特生物科技(深圳)有限公司 | Chemiluminescence immunoassay appearance |
| CN210090482U (en) * | 2019-05-31 | 2020-02-18 | 艾特生物科技(深圳)有限公司 | Immunoassay appearance and magnetic bead washs separator, mixing device thereof |
| CN210323047U (en) * | 2019-03-27 | 2020-04-14 | 苏州长光华医生物医学工程有限公司 | Magnetic cleaning and separating device of immunoassay analyzer |
| CN112119312A (en) * | 2018-02-08 | 2020-12-22 | 成都深迈瑞医疗电子技术研究院有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN112630454A (en) * | 2020-10-16 | 2021-04-09 | 嘉兴凯实生物科技股份有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
-
2021
- 2021-06-15 CN CN202110661101.3A patent/CN113504380A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050042138A1 (en) * | 2003-08-20 | 2005-02-24 | Sysmex Corporation | Sample analyzer, nucleic acid detector and nucleic acid detection method |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
| CN204953107U (en) * | 2015-09-02 | 2016-01-13 | 苏州长光华医生物医学工程有限公司 | Reactant washs device of separation in chemiluminescent immunoassay luminesceence analysis appearance |
| CN107144689A (en) * | 2017-06-28 | 2017-09-08 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer magnetic cleaning separating mechanism of magnet one side arrangement |
| CN207816996U (en) * | 2017-09-20 | 2018-09-04 | 深圳迈瑞生物医疗电子股份有限公司 | A kind of automatic analysing apparatus |
| CN109917145A (en) * | 2017-12-12 | 2019-06-21 | 深圳拓真生物科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN107966579A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | One kind has biochemistry, enzyme is exempted from and chemiluminescence rapid detection system and method |
| CN112119312A (en) * | 2018-02-08 | 2020-12-22 | 成都深迈瑞医疗电子技术研究院有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN109433686A (en) * | 2018-12-27 | 2019-03-08 | 上海奥普生物医药有限公司 | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter |
| CN210323047U (en) * | 2019-03-27 | 2020-04-14 | 苏州长光华医生物医学工程有限公司 | Magnetic cleaning and separating device of immunoassay analyzer |
| CN210090481U (en) * | 2019-05-31 | 2020-02-18 | 艾特生物科技(深圳)有限公司 | Chemiluminescence immunoassay appearance |
| CN210090482U (en) * | 2019-05-31 | 2020-02-18 | 艾特生物科技(深圳)有限公司 | Immunoassay appearance and magnetic bead washs separator, mixing device thereof |
| CN110672835A (en) * | 2019-09-26 | 2020-01-10 | 合肥运涛光电科技有限公司 | Magnetic separation mechanism for chemiluminescence immunoassay system |
| CN112630454A (en) * | 2020-10-16 | 2021-04-09 | 嘉兴凯实生物科技股份有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114113048A (en) * | 2021-11-23 | 2022-03-01 | 南京晶捷生物科技有限公司 | Optical detection equipment |
| CN114113048B (en) * | 2021-11-23 | 2023-10-27 | 南京晶捷生物科技有限公司 | Optical detection equipment |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
| CN114660317A (en) * | 2022-02-10 | 2022-06-24 | 北京胡曼智造科技有限责任公司 | Flow type fluorescence luminescence immunoassay instrument |
| CN114660317B (en) * | 2022-02-10 | 2023-11-17 | 北京胡曼智造科技有限责任公司 | Flow type fluorescent luminous immunity analyzer |
| CN114384063A (en) * | 2022-03-23 | 2022-04-22 | 深圳天辰医疗科技有限公司 | Chemiluminescence apparatus |
| WO2023198910A1 (en) | 2022-04-15 | 2023-10-19 | Quantoom Biosciences S.A. | System and method for the production of rna |
| BE1030468B1 (en) * | 2022-04-20 | 2023-11-21 | Quantoom Biosciences S A | SYSTEM AND METHOD FOR RNA PRODUCTION |
| CN114965886B (en) * | 2022-05-18 | 2023-11-03 | 深圳无疆生命科学有限公司 | Sample loading tray device and sample analyzer |
| CN114965886A (en) * | 2022-05-18 | 2022-08-30 | 深圳无疆生命科学有限公司 | Sample adding disc device and sample analyzer |
| CN115407078A (en) * | 2022-11-01 | 2022-11-29 | 丹娜(天津)生物科技股份有限公司 | Analyzer with sample preprocessing function and sample preprocessing method |
| CN116087484A (en) * | 2022-11-11 | 2023-05-09 | 重庆智迈医疗科技有限公司 | Compact high-efficiency magnetic particle immunity analyzer |
| CN116087484B (en) * | 2022-11-11 | 2023-11-07 | 重庆智迈医疗科技有限公司 | Compact high-efficiency magnetic particle immunity analyzer |
| CN116519964A (en) * | 2023-07-04 | 2023-08-01 | 珠海丽珠试剂股份有限公司 | Automatic analysis system and control method thereof |
| CN116519964B (en) * | 2023-07-04 | 2023-09-01 | 珠海丽珠试剂股份有限公司 | Automatic analysis system and control method thereof |
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