CN210090482U - Immunoassay appearance and magnetic bead washs separator, mixing device thereof - Google Patents
Immunoassay appearance and magnetic bead washs separator, mixing device thereof Download PDFInfo
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- CN210090482U CN210090482U CN201920810866.7U CN201920810866U CN210090482U CN 210090482 U CN210090482 U CN 210090482U CN 201920810866 U CN201920810866 U CN 201920810866U CN 210090482 U CN210090482 U CN 210090482U
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Abstract
The utility model discloses an immunoassay appearance and magnetic bead wash separator, mixing device thereof, wherein the mixing device includes first magnetic part and grabs cup mixing mechanism. The first magnetic part generates a magnetic field to attract the magnetic beads in the reaction cup to move; the cup grabbing and mixing mechanism drives the reaction cup to move so as to carry out mixing. That is, when the cup grabbing and mixing mechanism mixes the substances in the reaction cup, the magnetic beads move; the first magnetic part applies a magnetic field to the reaction cup to cause the magnetic beads to do another type of movement, the superposition of the two types of movement is more beneficial to uniformly mixing the substances in the reaction cup, the rotating speed of the reaction cup in the cup grabbing and uniformly mixing mechanism can be reduced, and the reliability of the device is improved.
Description
Technical Field
The utility model relates to the field of medical equipment, concretely relates to immunoassay appearance and magnetic bead washs separator, mixing device thereof.
Background
With the improvement of the living standard of people and the progress of medical technology, the application of the full-automatic chemiluminescence immunoassay analyzer is more and more extensive and popular. The full-automatic chemiluminescence immunoassay analyzer is equipment for analyzing by directly marking antigen and antibody with a chemiluminescence reagent. The automatic sampling, sample adding, reaction and detection device can automatically complete a series of processes such as sampling, sample adding, reaction and detection, improves the detection efficiency and reduces errors caused by manual operation. Due to the wide application of the chemiluminescence technology in immunoassay, higher requirements are put forward for the problem of magnetic bead cleaning and separation in the luminescence detection process. The magnetic bead cleaning and separating is to clean the magnetic particle compound (magnetic bead) and separate the magnetic particle compound from the solid and liquid of the reaction liquid, and in order to ensure the accuracy of detection, the reaction liquid and the magnetic particles are fully mixed, and the liquid is injected and absorbed for multiple times to clean so as to remove impurities. At present, the cleaning of magnetic beads is generally performed by rotating and mixing through a mixing device after liquid injection, and during rotating and mixing (centrifugal mixing), if the rotating speed is low, the mixing is easy to be uneven, and if the rotating speed is high, the noise is high, and the motor is easy to break down; this indicates that the blending effect of the blending device is not good, or the reliability of the blending device needs to be improved, and the reliability of the final luminescence detection result of the analyzer is also affected.
Therefore, the technology of mixing magnetic beads in the chemiluminescence immunoassay analyzer at the present stage needs to be improved.
SUMMERY OF THE UTILITY MODEL
The utility model aims to overcome prior art's shortcoming and not enough to improve the effect of magnetic bead mixing.
According to the utility model discloses an aspect, the utility model provides a mixing device for reaction cup, include:
the first magnetic part is used for generating a magnetic field to attract the magnetic beads in the reaction cup to move;
and the cup grabbing and mixing mechanism is used for driving the reaction cups to move so as to carry out mixing.
The blending device, wherein, first magnetic part sets up side, top or below of reaction cup lateral wall, the magnetic field direction of first magnetic part is different with the direction of motion of reaction cup.
Mixing device, wherein, grab cup mixing mechanism and include: the device comprises cup claws for grabbing the reaction cup and sleeves sleeved outside the cup claws; the sleeve drives the cup claws to rotate so as to enable the grabbed reaction cup to rotate, so that the reaction cup can be uniformly mixed.
The mixing device, wherein, the inside cavity of cup claw to hold move down and push away the reaction cup from cup claw.
According to the utility model discloses a second aspect, the utility model provides a magnetic bead washs separator, include: at least one blending device, a base, a cleaning pot, a rotating shaft, a first power device, a cleaning turntable and an upper lifting plate and a lower lifting plate;
the cleaning pot is arranged on the base, the cleaning rotary disc is arranged in the cleaning pot, and a plurality of accommodating parts for accommodating reaction cups are arranged on the cleaning rotary disc; the upper lifting plate and the lower lifting plate are positioned above the cleaning turntable, and a cup grabbing and blending mechanism of the blending device is arranged on the upper lifting plate and the lower lifting plate; the cleaning pot is provided with a shaft hole; the rotating shaft is arranged in the shaft hole and used for driving the cleaning turntable to rotate around the rotating shaft; the first power device is in transmission connection with the rotating shaft and used for driving the rotating shaft to rotate.
In the magnetic bead cleaning and separating device, the upper and lower lifting plates are also provided with at least one liquid injection needle for injecting liquid and at least one liquid suction needle correspondingly for sucking liquid; the liquid injection level is arranged below the liquid injection needle, and the liquid suction level is arranged below the liquid suction needle; the cleaning turntable is used for driving the reaction cup to rotate to the liquid injection level for injecting liquid and driving the reaction cup to rotate to the liquid absorption level for absorbing liquid.
In the magnetic bead cleaning and separating device, a magnetic separating device is arranged on the side wall of the cleaning pot corresponding to the liquid absorbing level, and the magnetic separating device is used for absorbing the magnetic beads in the reaction cup on the cup wall of the reaction cup; the first magnetic part of the blending device is arranged on the side wall of the cleaning pot corresponding to the liquid injection level; the magnetic separation device comprises a second magnetic piece, wherein the magnetic induction intensity of the first magnetic piece is smaller than that of the second magnetic piece.
The magnetic bead cleaning and separating device also comprises a cup returning mechanism, a first guide rail, a second power device and a cover plate, wherein the cover plate is positioned between the cleaning turntable and the upper and lower lifting plates; the first guide rail is vertically arranged on the cover plate, or is vertically arranged on the cleaning pot, or is vertically arranged on the base; the second power device is used for driving the upper lifting plate and the lower lifting plate to move up and down on the first guide rail; the first guide rail is coaxial with the rotating shaft; move back a cup mechanism and include: the cup returning cylinder, a second guide rail vertically arranged on the upper lifting plate and the lower lifting plate, a third power device and a cup returning plate arranged in parallel with the upper lifting plate and the lower lifting plate; the cup withdrawing cylinder is arranged in the cup grabbing and mixing mechanism; a stop block is arranged at the bottom end of the cup withdrawing cylinder; the cup withdrawing plate is contacted with the top end of the cup withdrawing cylinder; the third power device is used for driving the cup returning plate to move up and down on the second guide rail, the cup returning plate drives the cup returning cylinder to move down relative to the cup grabbing and mixing mechanism through moving down, so that the reaction cup is pushed away by the stop dog to be grabbed by the cup grabbing and mixing mechanism.
The magnetic bead cleaning and separating device is characterized in that the cup withdrawing cylinder is hollow and is used for accommodating a liquid injection needle.
According to the third aspect of the present invention, the present invention provides an immunoassay analyzer, comprising the magnetic bead cleaning and separating device as described above.
To sum up, the utility model discloses an immunoassay appearance and magnetic bead wash separator, mixing device thereof, wherein the mixing device includes first magnetic part and grabs cup mixing mechanism. The first magnetic part generates a magnetic field to attract the magnetic beads in the reaction cup to move; the cup grabbing and mixing mechanism drives the reaction cup to move so as to carry out mixing. That is, when the cup grabbing and mixing mechanism mixes the substances in the reaction cup, the magnetic beads move; the first magnetic part applies a magnetic field to the reaction cup to cause the magnetic beads to do another type of movement, the superposition of the two types of movement is more beneficial to uniformly mixing the substances in the reaction cup, the rotating speed of the reaction cup in the cup grabbing and uniformly mixing mechanism can be reduced, and the reliability of the device is improved.
Drawings
FIG. 1 is an isometric view of a magnetic bead washing and separating device according to an embodiment of the present invention;
FIG. 2 is a top view of a magnetic bead washing and separating device according to an embodiment of the present invention;
FIG. 3 is a cross-sectional view taken along line Y-Y of FIG. 2;
FIG. 4 is a schematic diagram of the magnetic bead cleaning and separating device according to an embodiment of the present invention;
fig. 5 is an exploded view of a cup grabbing and mixing mechanism according to an embodiment of the present invention;
FIG. 6 is an enlarged view of a portion of the mixing mechanism of FIG. 3.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those skilled in the art without creative efforts belong to the protection scope of the present invention.
As shown in fig. 1-3, the utility model provides a magnetic bead cleaning and separating device, include: the device comprises a base 10, a cleaning pot 20 arranged (for example, mounted) on the base 10, a rotating shaft 21, a first power device 22, a cleaning turntable 23 arranged in the cleaning pot 20, a cover plate 24 positioned above the cleaning turntable 23, an upper lifting plate 30 and a lower lifting plate 30 positioned above the cover plate 24, at least one blending device and a magnetic separation device 26.
The base 10 and the cleaning pot 20 are provided with shaft holes, and the rotating shaft 21 is arranged in the shaft holes through bearings. The rotating shaft 21 is used for driving the cleaning turntable 23 to rotate around the rotating shaft 21. The first power device 22 is in transmission connection with the rotating shaft 21 and is used for driving the rotating shaft 21 to rotate. In this embodiment, the first power device 22 is a stepping motor, and is in transmission connection with the rotating shaft 21 through a belt pulley 27. The pulley 27 also acts to decelerate the stepper motor.
The cleaning turntable 23 is provided with a plurality of accommodating portions for accommodating the reaction cups X, and the accommodating portions are specifically accommodating grooves adapted to the reaction cups X in this embodiment.
The cover plate 24 is a cover plate of the washing tub 20 to protect the washing turntable 23 and the like in the washing tub 20.
The blending device is used for blending the substances in the reaction cup, and comprises: a first magnetic part 25 and a cup grabbing and mixing mechanism 31.
Grab a glass mixing mechanism 31 and set up on the oscilaltion board 30, grab a glass mixing mechanism 31 and be used for driving the reaction cup motion is in order to carry out the mixing, and is specific for snatch the reaction cup X in the holding portion and with the material misce bene in the reaction cup X. In this embodiment, the cup grabbing and mixing mechanism 31 mixes the substances in the reaction cup X by rotating the reaction cup X, specifically, the rotation mode is forward rotation and reverse rotation, that is, the forward rotation and the reverse rotation are alternately performed, so as to sufficiently mix the substances in the reaction cup X.
The first magnetic member 25 is configured to generate a magnetic field to attract magnetic beads in the reaction cup to move, and specifically, is configured to apply the magnetic field to the reaction cup X when the cup grabbing and mixing mechanism 31 mixes substances in the reaction cup X, so as to promote uniform mixing of the substances in the reaction cup X. The first magnetic member 25 may be disposed at a side, an upper side or a lower side of the sidewall of the cuvette X, and the magnetic field direction may be different from the moving direction of the cuvette X. In this embodiment, the magnetic field direction is perpendicular to the rotation axis of the reaction cup X, i.e., the first magnetic member 25 is disposed on the sidewall of the washing pot 20. There is the magnetic bead in the reaction cup X, when reaction cup X is rotatory, centrifugal motion is done to the magnetic bead, and the effect in magnetic field makes the magnetic bead move on the horizontal direction, and the magnetic bead removes mixed and disorderly more, and the easier misce bene is more to make the required rotational speed of reaction cup X reduce, the rotational speed has hanged down, and the beating of mixing in-process reaction cup X is just little, and the reaction liquid splashes for a short time, and the magnetic bead loss is few, grabs cup mixing mechanism 31 longe-lived, has improved magnetic bead washing separator's reliability. The first magnetic member 25 may be a permanent magnet or an electromagnet, and in this embodiment, an electromagnet is adopted, and when the cup grabbing and mixing mechanism 31 mixes the substances in the reaction cup X, the first magnetic member 25 not only applies a magnetic field to the reaction cup X, but also further improves the uniformity of mixing the substances in the reaction cup X by changing the polarity, the magnitude of the magnetic induction intensity and/or the presence or absence of the magnetic field.
The up-down lifting plate 30 is further provided with at least one liquid injection needle 32 for injecting liquid and at least one liquid suction needle 33 for sucking liquid. The liquid injection level is arranged below the liquid injection needle 32, and the liquid suction level is arranged below the liquid suction needle 33; the cleaning turntable 23 is used for driving the reaction cup X to rotate to the liquid injection level for liquid injection, and driving the reaction cup X to rotate to the liquid absorption level for liquid absorption.
A magnetic separation device 26 is arranged on the side wall of the cleaning pot 20 corresponding to the liquid absorption position, and the magnetic separation device 26 is used for adsorbing the magnetic beads in the reaction cup X on the cup wall of the reaction cup X. That is, after the magnetic beads and the cleaning solution are uniformly mixed, the reaction cup X rotates to the absorption level, the magnetic separation device 26 absorbs the magnetic beads in the reaction cup X on the cup wall of the reaction cup, and then absorbs the cleaning solution in the reaction cup X to complete the primary magnetic bead cleaning.
As shown in fig. 4, the magnetic bead washing and separating device has at least one sample injection level a, at least one liquid injection level B, at least one liquid absorption level E, and at least one bottom injection level F. The sample injection site a is a site for placing the cuvette X, and of course, may also be used for removing the cuvette X, and correspondingly, the cover plate 24 has a through hole for placing or removing the cuvette X into or from the accommodating portion. Annotate liquid level B for being used for annotating the station of washing liquid to reaction cup X, all be provided with one on every annotating liquid level B and grab cup mixing mechanism 31 and annotate liquid needle 32, corresponding, have a through-hole on the apron 24 and supply to grab cup mixing mechanism 31 and snatch reaction cup X. The liquid suction level E is a station for sucking away the cleaning liquid in the reaction cup X, and each liquid suction level E is provided with a liquid suction needle 33. The bottom injection objects F are stations for injecting substrates, each bottom injection object F is provided with a cup grabbing and mixing mechanism 31 and an injection port 34 for injecting the substrates, and correspondingly, the cover plate 24 is provided with a through hole for the cup grabbing and mixing mechanism 31 to grab the reaction cup X. Each station is arrayed on the circumference of a circle centered on the rotary shaft 21.
In this embodiment, two magnetic separation positions C and D are further disposed between the liquid injection position B and the liquid suction position E, the magnetic separation position C is a station for adsorbing magnetic beads in the reaction cup X on the cup wall of the reaction cup X, that is, the side wall of the cleaning pot 20 corresponding to the magnetic separation position is also provided with the magnetic separation device 26. After the magnetic beads are uniformly mixed at the liquid injection position B, the magnetic beads are subjected to the action of a strong magnetic field of the magnetic separation device 26 at other stations, can be fully adsorbed on the cup wall of the reaction cup X, greatly reduces the loss rate of the magnetic beads during liquid suction, and ensures the accuracy of subsequent testing. In this embodiment, the stations of B-E are all provided with three, and in this embodiment, the magnetic bead washs for three times, and it is fully effectual to wash.
The magnetic separating device 26 comprises a second magnetic part, and similarly, the second magnetic part can adopt a permanent magnet or an electromagnet. The magnetic induction intensity of the first magnetic member 25 is less than that of the second magnetic member, and after all, the two magnetic members have different functions, the first magnetic member 25 only needs to move the magnetic beads, and the second magnetic member needs to adsorb the magnetic beads so that the magnetic beads do not move.
The utility model provides a magnetic bead washs separator still includes first guide rail 41 and second power device 42. The first guide rail 41 may be vertically disposed on the cover plate 24, the cleaning pot 20, or the base 10, in this embodiment, the first guide rail 41 is vertically disposed on the cover plate 24. The second power unit 42 is used to drive the up-down moving plate 30 to move up and down on the first guide rail 41. Further, the first guide rail 41 is coaxial with the rotary shaft 21. Since the cleaning pot 20 has a cylindrical shape and the rotation shaft 21 is located at the center of the cleaning pot 20, the first guide rail 41 is also located at the center of the up-down lifting plate 30, and two first auxiliary guide rails 43 are further provided on the cover plate 24, the two first auxiliary guide rails 43 being symmetrical with respect to the first guide rail 41 to balance the up-down lifting plate 30. The upper and lower elevating plates 30 are engaged with the first auxiliary guide rail 43 through linear bearings. The second power device 42 may be a motor, pneumatic or hydraulic device to drive the upper and lower lifting plates 30 to move up and down, and in this embodiment, the second power device 42 is a linear motor. The upper and lower elevating plates 30 can be smoothly elevated by the linear motor 42, the three guide rails 41/43 and the linear bearings.
The upper and lower elevating plates 30 are disposed parallel to the cover plate 24 and have a gap at the sample injection site A to facilitate the entry and exit of the cuvette X.
The utility model provides a magnetic bead washs separator still includes moves back cup mechanism 50. Referring to fig. 5, the cup returning mechanism 50 includes: a cup withdrawing cylinder 311, a second guide rail 51 vertically arranged on the upper and lower elevating plates 30, a third power device 52, and a cup withdrawing plate 53 arranged in parallel with the upper and lower elevating plates 30. The cup returning plate 53 contacts the top end of the cup returning cylinder 311. The bottom of the cup withdrawing cylinder 311 is provided with a stopper 3110. The third power device 52 is used for driving the cup withdrawing plate 53 to move up and down on the second guide rail 51, and the cup withdrawing plate 53 drives the cup withdrawing cylinder 311 to move down relative to the cup grabbing and mixing mechanism through moving down, so as to push the reaction cup X away from the cup grabbing and mixing mechanism through the stopper 3110, that is, to withdraw the reaction cup X in the cup grabbing and mixing mechanism into the accommodating part. The up-down lifting plate 30 is further provided with two second auxiliary guide rails which are symmetrical with respect to the second guide rail 51 to balance the cup withdrawing plate 53. The cup withdrawing plate 53 is matched with the second auxiliary guide rail through a linear bearing. The third power device 52 can use a motor, air pressure or hydraulic pressure to drive the cup withdrawing plate 53 to move up and down, and in this embodiment, the third power device 52 is a linear motor. The cup withdrawing plate 53 can be lifted and lowered stably through the linear motor 52, the three guide rails and the linear bearing.
Referring to fig. 6, the cup-grasping and mixing mechanism 31 includes: a cup claw 312 for grabbing the reaction cup, a sleeve 313 sleeved outside the cup claw 312, a bearing 314 and a fourth power device 315. The inside of the cup claw 312 is hollow, and the cup claw 312 is sleeved on the cup withdrawing cylinder 311. The inner ring of the bearing 314 is sleeved on the sleeve 313, and the outer ring of the bearing 314 is fixed on the upper and lower lifting plates 30; the fourth power device 315 is drivingly connected to the sleeve 313 for driving the sleeve 313 and the cup jaw 312 to rotate. Specifically, the fourth power device 315 is a motor, a pulley 316 is further sleeved on the upper portion of the sleeve 313, and the fourth power device 315 is in transmission connection with the pulley 316 through a belt 317. In this embodiment, there are three cup-grasping blending mechanisms 31, which share one fourth power device 315 and one belt 317. Namely, one electrode is adopted to drive the three cup grabbing and mixing mechanisms 31 to mix the solid-liquid mixture in the reaction cup X uniformly, and the structure is compact and the efficiency is high. In this embodiment, the cup jaws 312 are PEEK (polyetheretherketone) cup jaws, which are strong and wear resistant. The outer wall of the reaction cup X is provided with a flange, which is convenient to be clamped and fixed by a plurality of claws 3120 at the bottom of the cup claw 312. Wherein, each jack catch 3120, each dog 3110 all arrange in the circumference array, set up a dog 3110 between two jack catches 3120 for moving back cup cylinder 311 and reciprocate and can not influence the cup claw 312.
As shown in fig. 3, both ends of the cup retreating plate 53 are in contact with one cup retreating cylinder 311, that is, the cup retreating plate 53 can push the reaction cup X in the corresponding cup grabbing and mixing mechanism 31 into the accommodating portion through the two cup retreating cylinders 311 at the same time. Specifically, as shown in fig. 6, the end of the cup returning plate 53 is located above the cup returning cylinder 311, the cup returning plate 53 moves downward to push the cup returning cylinder 311 to move downward, and the stopper 3110 at the bottom end of the cup returning cylinder 311 pushes the reaction cup X held by the claw 3120 back to the accommodating portion.
The cup withdrawing cylinder 311 is hollow inside and is used for accommodating the liquid injection needle 32. Therefore, the structure related to liquid injection, cup grabbing and mixing is quite compact, and the space is saved. The upper and lower lifting plates 30 are further provided with a bracket 35, the bracket 35 is used for fixing the liquid injection needle 32, and the liquid injection needle 32 penetrates into the cup withdrawing cylinder 311 from top to bottom. The raising and lowering of the upper and lower lift plates 30 has two operating positions, a high position and a low position. When the upper and lower lifting plates 30 are lowered to the low position, the liquid injection needle 32 extends into the reaction cup X to inject liquid; when the upper and lower elevating plates 30 are raised to the high position, the liquid injection needle 32 leaves the reaction cup X, and the cup grabbing and mixing mechanism 31 drives the reaction cup X to rotate.
The utility model provides a magnetic bead washs separator is applicable to immunoassay appearance, and this immunoassay appearance is still including the controller that is used for controlling magnetic bead washing separator. The controller is electrically connected with each power device. The controller controls the magnetic bead cleaning and separating device to work according to the following flow:
after the reaction cup X enters the containing part from the sample injection position A, the controller drives the cleaning turntable to rotate through the first power device, the reaction cup X moves to the liquid injection position B, the liquid injection needle 32 injects cleaning liquid into the reaction cup X, the controller drives the upper lifting plate and the lower lifting plate to descend through the second power device, the cup grabbing and mixing mechanism 31 grabs the reaction cup X, the upper lifting plate and the lower lifting plate are driven to ascend through the second power device, the cup grabbing and mixing mechanism 31 is driven to rotate through the fourth power device, and magnetic beads are mixed with the cleaning liquid under the action of centrifugal force and a magnetic field emitted by the first magnetic part. And then, the cup withdrawing plate is driven by a third power device to move downwards, and the cup withdrawing cylinder is driven to push the reaction cup X downwards into the accommodating part. The first power device of the controller drives the cleaning turntable to rotate, so that the reaction cup X sequentially passes through the two magnetic separation positions C and D and then reaches the liquid absorption level E. The magnetic beads are adsorbed on the cup wall of the reaction cup X under the action of the magnetic separation device, and the liquid suction needle sucks away cleaning liquid and impurities, so that the first magnetic bead cleaning is completed. The cleaning process is repeated until the magnetic bead cleaning for the third time is completed, then the cleaning turntable is driven to rotate through the first power device, the reaction cup X moves to the bottom filling material level F, the substrate is injected into the reaction cup X from the injection port 34, the controller drives the upper lifting plate and the lower lifting plate to descend through the second power device, the reaction cup X is grabbed by the cup grabbing and mixing mechanism 31, the upper lifting plate and the lower lifting plate are driven to ascend through the second power device, the cup grabbing and mixing mechanism 31 is driven to rotate through the fourth power device, and the magnetic bead is mixed with the substrate under the action of centrifugal force and a magnetic field emitted by the first magnetic part.
It can be seen that, the utility model provides a magnetic bead washs separator, the mixing mode is unique, and the magnetic bead still increases a reciprocating motion except doing centrifugal mixing, has reduced centrifugal mixing's speed requirement, the effectual motor that has protected, and the mixing is effectual simultaneously, and the mixing uniformity is good, and mixing in-process reaction cup beats for a short time, and the reaction liquid splashes for a short time, and the magnetic bead loss is few, has guaranteed the degree of accuracy of follow-up test result. The liquid suction and the liquid injection adopt the same layer structure, and the structure is simple and compact due to the linear motor and the linear bearing kinematic pair.
It is right to have used specific individual example above the utility model discloses expound, only be used for helping to understand the utility model discloses, not be used for the restriction the utility model discloses. To the technical field of the utility model technical personnel, the foundation the utility model discloses an idea can also be made a plurality of simple deductions, warp or replacement.
Claims (10)
1. The utility model provides a mixing device for reaction cup which characterized in that includes:
the first magnetic part is used for generating a magnetic field to attract the magnetic beads in the reaction cup to move;
and the cup grabbing and mixing mechanism is used for driving the reaction cups to move so as to carry out mixing.
2. The blending device according to claim 1, wherein the first magnetic member is disposed at a side, above or below the sidewall of the reaction cup, and the magnetic field direction of the first magnetic member is different from the moving direction of the reaction cup.
3. The blending device of claim 1 or 2, wherein the cup grasping blending mechanism comprises: the device comprises cup claws for grabbing the reaction cup and sleeves sleeved outside the cup claws; the sleeve drives the cup claws to rotate so as to enable the grabbed reaction cup to rotate, so that the reaction cup can be uniformly mixed.
4. The blending apparatus of claim 3, wherein the cup jaws are hollow to accommodate downward movement of the cup ejection mechanism to push the reaction cups away from the cup jaws.
5. A magnetic bead cleaning and separating device is characterized by comprising: at least one mixing apparatus according to any one of claims 1 to 4, a base, a cleaning pan, a rotating shaft, a first power device, a cleaning turntable, and upper and lower lifting plates;
the cleaning pot is arranged on the base, the cleaning rotary disc is arranged in the cleaning pot, and a plurality of accommodating parts for accommodating reaction cups are arranged on the cleaning rotary disc; the upper lifting plate and the lower lifting plate are positioned above the cleaning turntable, and a cup grabbing and blending mechanism of the blending device is arranged on the upper lifting plate and the lower lifting plate; the cleaning pot is provided with a shaft hole; the rotating shaft is arranged in the shaft hole and used for driving the cleaning turntable to rotate around the rotating shaft; the first power device is in transmission connection with the rotating shaft and used for driving the rotating shaft to rotate.
6. The magnetic bead washing and separating device of claim 5, wherein the upper and lower lifting plates are further provided with at least one liquid injection needle for injecting liquid and at least one liquid suction needle corresponding to the liquid suction needle; the liquid injection level is arranged below the liquid injection needle, and the liquid suction level is arranged below the liquid suction needle; the cleaning turntable is used for driving the reaction cup to rotate to the liquid injection level for injecting liquid and driving the reaction cup to rotate to the liquid absorption level for absorbing liquid.
7. The device for cleaning and separating magnetic beads as claimed in claim 6, wherein a magnetic separation device is disposed on a side wall of the cleaning pot corresponding to the liquid absorption level, and the magnetic separation device is used for adsorbing the magnetic beads in the reaction cup on a cup wall of the reaction cup; the first magnetic part of the blending device is arranged on the side wall of the cleaning pot corresponding to the liquid injection level; the magnetic separation device comprises a second magnetic piece, wherein the magnetic induction intensity of the first magnetic piece is smaller than that of the second magnetic piece.
8. The device for washing and separating magnetic beads of claim 5, further comprising a cup returning mechanism, a first guide rail, a second power device and a cover plate, wherein the cover plate is positioned between the washing turntable and the upper and lower lifting plates; the first guide rail is vertically arranged on the cover plate, or is vertically arranged on the cleaning pot, or is vertically arranged on the base; the second power device is used for driving the upper lifting plate and the lower lifting plate to move up and down on the first guide rail; the first guide rail is coaxial with the rotating shaft; move back a cup mechanism and include: the cup returning cylinder, a second guide rail vertically arranged on the upper lifting plate and the lower lifting plate, a third power device and a cup returning plate arranged in parallel with the upper lifting plate and the lower lifting plate; the cup withdrawing cylinder is arranged in the cup grabbing and mixing mechanism; a stop block is arranged at the bottom end of the cup withdrawing cylinder; the cup withdrawing plate is contacted with the top end of the cup withdrawing cylinder; the third power device is used for driving the cup returning plate to move up and down on the second guide rail, the cup returning plate drives the cup returning cylinder to move down relative to the cup grabbing and mixing mechanism through moving down, so that the reaction cup is pushed away by the stop dog to be grabbed by the cup grabbing and mixing mechanism.
9. The device for washing and separating magnetic beads of claim 8, wherein the cup withdrawing cylinder is hollow inside and is used for accommodating a liquid injection needle.
10. An immunoassay analyzer comprising the magnetic bead washing and separating device according to any one of claims 5 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920810866.7U CN210090482U (en) | 2019-05-31 | 2019-05-31 | Immunoassay appearance and magnetic bead washs separator, mixing device thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920810866.7U CN210090482U (en) | 2019-05-31 | 2019-05-31 | Immunoassay appearance and magnetic bead washs separator, mixing device thereof |
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| CN210090482U true CN210090482U (en) | 2020-02-18 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112625862A (en) * | 2020-12-29 | 2021-04-09 | 安图实验仪器(郑州)有限公司 | Draw a magnetism to inhale auto-change over device |
| CN113504380A (en) * | 2021-06-15 | 2021-10-15 | 复星诊断科技(上海)有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN113770104A (en) * | 2021-10-20 | 2021-12-10 | 深圳市博辰智控有限公司 | Magnetic cleaning and separating device and method for chemiluminescence immunoassay analyzer |
| WO2022115981A1 (en) * | 2020-12-01 | 2022-06-09 | 王锦弘 | Centrifugal reaction device and centrifugal reaction method |
| CN114965888A (en) * | 2022-05-18 | 2022-08-30 | 深圳无疆生命科学有限公司 | Magnetic separation cleaning device and sample analyzer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022115981A1 (en) * | 2020-12-01 | 2022-06-09 | 王锦弘 | Centrifugal reaction device and centrifugal reaction method |
| CN112625862A (en) * | 2020-12-29 | 2021-04-09 | 安图实验仪器(郑州)有限公司 | Draw a magnetism to inhale auto-change over device |
| CN113504380A (en) * | 2021-06-15 | 2021-10-15 | 复星诊断科技(上海)有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN113770104A (en) * | 2021-10-20 | 2021-12-10 | 深圳市博辰智控有限公司 | Magnetic cleaning and separating device and method for chemiluminescence immunoassay analyzer |
| CN114965888A (en) * | 2022-05-18 | 2022-08-30 | 深圳无疆生命科学有限公司 | Magnetic separation cleaning device and sample analyzer |
| CN114965888B (en) * | 2022-05-18 | 2024-03-01 | 深圳无疆生命科学有限公司 | Magnetic separation cleaning device and sample analyzer |
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