CN220514890U - Cleaning device - Google Patents

Abstract

The utility model discloses a cleaning device, comprising: a plurality of cup positions for accommodating the reaction cups are circumferentially distributed on the turntable; the cleaning assemblies are sequentially distributed along the periphery of the turntable and comprise liquid injection needles and cleaning needles; according to the cleaning sequence of the reaction cup, a plurality of magnet blocks with gradually reduced heights are arranged on one side of the cup position between the last group of liquid injection needles and the cleaning needles. The height of the magnetic block group close to the filling mechanism is gradually reduced, so that more magnetic beads can be gathered into a group instead of being gathered at different heights of the reaction cup in a dispersing way, the magnetic beads can be enabled to react with the excitation liquid more thoroughly, and the sufficient luminous quantity and accurate measurement result are ensured.

Description

Cleaning device

Technical Field

The utility model relates to the technical field of sample analyzers, in particular to a cleaning device.

Background

In various sample analyzers, a chemiluminescent immunoassay method is one of the most common technologies, the technology is an analysis technology combining a chemiluminescent measurement technology with a high-specificity antigen-antibody reaction, magnetic beads in a reaction cup are required to be cleaned during detection, in a cleaning liquid sucking step in a cleaning process, magnetic elements are generally arranged on the side part of the reaction cup to adsorb the magnetic beads so as to avoid loss, the magnetic beads are attached to the side wall of the reaction cup under the action of the magnetic elements, and the side walls of the upper part, the middle part and the lower part of the reaction cup are all attached, excitation liquid filling is required after the cleaning is finished, and a certain amount of magnetic beads are attached to the higher position of the reaction cup, so that part of the magnetic beads cannot react with the excitation liquid effectively, the whole luminous quantity is influenced, and the accuracy of a detection result is lower.

Disclosure of Invention

The utility model discloses a cleaning device, which is used for solving the problem that in the prior art, partial magnetic beads of a reaction cup are attached to a higher position of the reaction cup after cleaning is finished, so that effective reaction with excitation liquid cannot be generated.

The present utility model provides a cleaning device, comprising: a plurality of cup positions for accommodating the reaction cups are circumferentially distributed on the turntable; the cleaning assemblies are sequentially distributed along the periphery of the turntable and comprise liquid injection needles and cleaning needles; according to the cleaning sequence of the reaction cup, a plurality of magnet blocks with gradually reduced heights are arranged on one side of the cup position between the last group of liquid injection needles and the cleaning needles.

Optionally, the magnetic block groups are arranged in halbach arrays or multipole magnetic circuits or magnetic focusing structures.

Optionally, the magnetic block group is formed by combining one or more magnetic units, and the single magnetic block group corresponds to the position of one reaction cup.

Optionally, a plurality of magnetic block groups are arranged on one side of the cup position between each group of liquid injection needles and the corresponding cleaning needles.

Optionally, a plurality of magnetic blocks between each liquid injection needle and the cleaning needle are sequentially connected.

Optionally, a mixing mechanism is arranged below at least part of the liquid injection needles.

Optionally, the mixing mechanism comprises a rotating shaft, a mixing power part and a connecting piece; the rotating shaft is in transmission connection with the mixing power part, and the rotation center of the rotating shaft and the rotation center of the connected reaction cup are not in the same straight line.

Optionally, the connecting piece is the columnar structure of coaxial being fixed in the pivot, the free end eccentric seting up of connecting piece is used for holding the recess of reaction cup, the lateral both ends of recess run through connecting piece lateral part, recess width slightly is greater than the reaction cup and corresponds the position external diameter.

Optionally, the output of pivot or mixing power portion is connected with the code wheel that resets, one side of code wheel that resets is provided with the opto-coupler that resets, the recess angle that indicates the connecting piece when the opto-coupler that resets is triggered to reset can supply the reaction cup to pass in and out.

Optionally, the rotating shafts and the mixing power parts are connected with synchronous wheels, and the synchronous wheels of the rotating shafts are connected with the synchronous wheels of the mixing power parts through synchronous belts.

The utility model adopts the technical proposal and has the following advantages:

1. the magnetic block group is arranged at the side part of the reaction cup, so that the magnetic beads in the reaction cup are prevented from being lost along with the pumping of the cleaning liquid, the height of the magnetic block group close to the filling mechanism is gradually reduced, more magnetic beads can be gathered into a group instead of being gathered at different heights of the reaction cup in a dispersing way, the magnetic beads can be enabled to react with the excitation liquid more thoroughly, and the sufficient luminous quantity and accurate measurement result are ensured; the height of the magnetic block group close to the liquid suction needle is gradually reduced, so that more magnetic beads can be gathered into a group instead of being distributed at all positions of the reaction cup as small groups, and the magnetic beads are further prevented from being sucked by the liquid suction needle;

2. the magnet blocks are arranged in a halbach array or a multipolar magnetic circuit or a magnetism-gathering structure, each magnet block is formed by combining one or more magnetic units, a single magnet block corresponds to the position of one reaction cup, and the magnet blocks enable the magnetic field intensity at one side of the reaction cup to be obviously increased through the arrangement mode, so that the adsorption speed of the magnet blocks to the magnet beads is faster, the adsorption force is stronger, and the loss of the magnet beads along with the washing waste liquid is avoided to a greater extent;

3. the utility model provides a still set up structures such as mixing subassembly, cleaning component in the detection device, cleaning component wash the material that easily influences the reaction result in with the reaction cup, mixing subassembly not only can make the more abundant and washing of washing liquid contact completion of magnetic bead when wasing, can also make magnetic bead and excitation liquid more thorough carry out the reaction when excitation liquid is annotated, guarantee that the luminous quantity is sufficient and measuring result is accurate.

Drawings

FIG. 1 is a schematic structural diagram of the present application;

FIG. 2 is an enlarged schematic view of a portion of a magnet block set at a fourth cleaning assembly of the present application;

FIG. 3 is a schematic view of the present application from another perspective of FIG. 1;

FIG. 4 is a schematic view showing a state that the cleaning device comprises a detection mechanism;

FIG. 5 is a schematic structural view of the mixing mechanism of the present application;

FIG. 6 is a schematic cross-sectional view of a blending mechanism of the present application;

fig. 7 is a schematic structural diagram of the direct connection between the mixing mechanism and the mixing power unit.

Reference numerals: the liquid filling device comprises a rotating shaft 1, a connecting piece 2, a groove 3, a motor 4, a reset code disc 5, a reset optocoupler 6, a synchronous wheel 7, a rotary disc 8, a first 911 liquid injection needle, a first 912 liquid suction needle, a second 921 liquid injection needle 922, a second liquid suction needle 931, a third liquid injection needle 932, a fourth 941 liquid injection needle 942, a fourth liquid suction needle 942, a group of 10 magnetic blocks, a cup ejection mechanism 11, a detection mechanism 12, a cup outlet 13, a cup inlet 14, a liquid injection plate 15, a liquid suction plate 16 and a filling mechanism 17.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully, and it is apparent that the embodiments described are only some, but not all, of the embodiments of the present application. All other embodiments, which can be made by those skilled in the art without the exercise of inventive faculty, are intended to be within the scope of the utility model.

A cleaning device comprises a rotary table 8 and a cleaning component; a plurality of cup positions for accommodating the reaction cups are circumferentially distributed on the turntable 8; each cleaning component is sequentially distributed along the periphery of the turntable 8 and comprises a liquid injection needle and a cleaning needle; according to the reaction cup cleaning sequence, one side of the cup position corresponding to the last group of liquid injection needles and the cleaning needles is provided with a plurality of magnetic block groups 10 with gradually reduced heights.

Referring to fig. 1, when the reaction cup moves along with the turntable 8, the magnetic block group 10 at the side can generate obvious adsorption action on the magnetic beads therein to enable the magnetic blocks to gather, and the height of the magnetic block group 10 of the final cleaning assembly is gradually reduced, so that the position of the magnetic field is gradually reduced, and the magnetic beads positioned at the high position of the reaction cup are gathered downwards to a low position, namely more magnetic beads gather into a group instead of being gathered into small groups originally and distributed at all positions of the reaction cup; when the excitation liquid is filled after the magnetic beads are washed and separated, the low-order aggregated magnetic beads are favorable for completely covering the excitation liquid, so that the magnetic beads react with the excitation liquid more thoroughly, and the sufficient luminous quantity and accurate measurement result are ensured.

Further, a plurality of magnetic block groups 10 are arranged between each group of liquid injection needles and the cleaning needles on one side corresponding to the cup position.

In this embodiment, the magnetic block groups 10 disposed between the other liquid injection needles and the cleaning needles may be disposed at the same height or may be disposed in a row at different heights; meanwhile, a magnetic block group 10 is arranged at the cup position corresponding to each liquid suction needle.

Similarly, the height of the magnetic block group 10 is gradually reduced, so that the concentration position of the magnetic field is gradually reduced, and the magnetic beads positioned at the high position of the reaction cup are concentrated downwards to a low position, namely more magnetic beads are concentrated into a group instead of being concentrated into small groups originally and distributed at all positions of the reaction cup; the probability of sucking the magnetic beads by the liquid sucking needle is further reduced by aggregation, and the magnetic beads are positioned at lower points so as to be in complete contact with the cleaning liquid to realize cleaning.

The magnetic block group 10 is arranged at the side part of the liquid suction needle, so that the magnetic beads are prevented from being discharged along with the waste liquid when the liquid suction needle sucks liquid, and the loss of the magnetic beads is avoided.

Further, a plurality of magnetic block groups 10 between each liquid injection needle and the cleaning needle are sequentially connected. When a plurality of magnetic block groups 10 are arranged between the liquid injection needle and the cleaning needle, the reaction cup runs between the liquid injection needle and the liquid suction needle, so that the magnetic beads can be adsorbed for aggregation in enough time, and the magnetic bead loss caused when liquid suction is conducted to cleaning liquid is further avoided.

Each magnetic block group 10 is arranged in a halbach array or a multipolar magnetic circuit or a magnetism gathering structure, each magnetic block group 10 is formed by combining one or a plurality of magnetic units, a single magnetic block group 10 corresponds to the position of a reaction cup, and the magnetic field intensity at one side of the reaction cup is obviously increased by the arrangement mode of the magnetic block groups 10, so that the adsorption speed of the magnetic block groups to magnetic beads is faster, the adsorption force is stronger, and the loss of the magnetic beads along with washing waste liquid is avoided to a greater extent.

The halbach array or the multipolar magnetic circuit or the magnetic focusing structure are all in a magnet arrangement mode which enables a magnetic field to be obviously enhanced at a certain position, wherein the halbach array is formed by splicing magnetic poles arranged in a rotating way through the angle of the magnetic field, so that a single-sided high-strength magnetic field is formed; the multipolar magnetic circuit is formed by magnetizing one magnet in multiple stages or absorbing a plurality of magnet monopole magnets, so that a magnetic field is gathered on the surface of the magnet; the magnetic focusing structure is formed by arranging magnets and iron yokes according to polarity opposition to realize magnetic field focusing; the selection and arrangement modes of the magnetic block groups 10 are all used for enabling the magnetic field intensity at the reaction cup to be larger and enabling the adsorption force to the magnetic beads to be stronger; in addition, the purpose of increasing the magnetic field strength can be achieved by selecting a single-sided magnet as the magnetic block group 10 and the like.

The magnetic block sets 10 are disposed on the outer peripheral side and/or the inner peripheral side of the corresponding cup position, and referring to fig. 3, the magnetic block sets 10 are disposed on the inner peripheral side and the outer peripheral side in this embodiment, so as to ensure that there is enough magnetic field strength at the reaction cup, so that the magnetic beads in the reaction cup can be gathered more quickly.

In the embodiment, the cleaning assemblies are provided with four groups, namely a first cleaning assembly, a second cleaning assembly, a third cleaning assembly and a fourth cleaning assembly according to the cleaning sequence of the reaction cup; the first cleaning assembly includes a first priming needle 911 and a first pipetting needle 912; the second cleaning assembly includes a second liquid injection needle 921 and a second liquid suction needle 922; the third cleaning assembly comprises a third liquid injection needle 931 and a third liquid suction needle 932; the fourth cleaning assembly includes a fourth fill needle 941, a fourth pipetting needle 942.

When the cleaning device works, the rotary table 8 carries the reaction cup to sequentially pass through the first cleaning assembly, the second cleaning assembly, the third cleaning assembly and the fourth cleaning assembly; when the reaction cup is cleaned, the corresponding liquid injection needle injects cleaning liquid into the reaction cup to clean the magnetic beads in the reaction cup, then the rotary table 8 carries the reaction cup to move to the liquid suction needle, the corresponding liquid suction is used for adsorbing waste liquid in the reaction cup, and the magnetic block group 10 is arranged between the reaction liquid injection needle and the liquid suction needle, so that the magnetic beads can be effectively prevented from being sucked out along with the cleaning waste liquid by the liquid suction needle, and the magnetic bead loss is caused.

One side of the turntable 8 is also provided with a filling mechanism 17 and a detection mechanism 12; the filling mechanism 17 is used for filling excitation liquid into the reaction cup after the magnetic bead cleaning is finished; the detection mechanism 12 is used for optically detecting the cuvette filled with the excitation liquid.

Referring to fig. 4, in this embodiment, the reaction cup enters the turntable 8 through the cup inlet 14, passes through a plurality of cleaning components, is filled with excitation liquid in the filling mechanism, then performs luminescence detection at the detection mechanism 12, and is taken out from the cup outlet 13 after the detection is completed.

Further, a mixing mechanism is arranged below the filling structure or/and at least part of the filling needles.

Referring to fig. 5, the mixing mechanism includes a rotating shaft 1, a mixing power portion and a connecting piece 2, the rotating shaft 1 is in transmission connection with the mixing power portion, so that the rotating shaft 1 is driven by the mixing power portion to rotate, the connecting piece 2 is used for connecting a reaction cup, the rotation center of the rotating shaft 1 is not in the same straight line with the rotation center of the reaction cup, so that the mixing power portion drives the reaction cup to eccentrically rotate during operation, rapid and effective shaking of substances inside the reaction cup is realized, and in the scheme, liquid in the reaction cup does not produce severe collision due to non-contact vortex mixing, so that pollution is not easily caused by splashing.

The connecting piece 2 can be in various specific structures, such as a clamping jaw for directly clamping the outer wall of the reaction cup, a supporting plate extending into the opening of the reaction cup from the upper part and propping against the side wall of the reaction cup, and the like, and a person skilled in the art can select a proper connecting piece 2 according to the actual operation environment, and simultaneously, the reaction cup can eccentrically rotate under the action of the connecting piece 2;

referring to fig. 6, in this embodiment, the connecting piece 2 is a columnar structure coaxially fixed on the rotating shaft 1, the free end of the connecting piece 2 is eccentrically provided with a groove 3 for accommodating a reaction cup, the width of the groove 3 is slightly larger than the outer diameter of the corresponding position of the reaction cup, the reaction cup can enter along the opening direction of the side part of the groove 3, then the mixing power part drives the rotating shaft 1 to rotate, the side wall of the groove 3 pushes the reaction cup to rotate, and the groove 3 of the connecting piece 2 is eccentrically arranged, so that the reaction cup is driven to eccentrically rotate when the connecting piece 2 rotates, and the mixing of substances inside the reaction cup is realized.

In another embodiment, the connecting piece 2 can also be arranged to be eccentrically fixed on the columnar structure of the rotating shaft 1, the middle part of the free end of the connecting piece 2 is provided with a groove 3 for accommodating the reaction cup, the width of the groove 3 is slightly larger than the outer diameter of the corresponding position of the reaction cup, the mixing power part drives the rotating shaft 1 to rotate after the reaction cup enters the groove 3, and the connecting piece 2 body can eccentrically rotate to drive the reaction cup positioned in the middle part of the connecting piece 2 to eccentrically rotate so as to realize the mixing of substances in the reaction cup.

The output end of the rotating shaft 1 or the mixing power part of the mixing mechanism is connected with a reset code disc 5, one side of the reset code disc 5 is provided with a reset optocoupler 6, when the reset code disc 5 triggers the reset optocoupler 6, the angle of the groove 3 of the indication connecting piece 2 can be used for a reaction cup to enter and exit, the reaction cup can be driven by the outside to enter and exit the groove 3 of the mixing mechanism from the horizontal direction, and the reset optocoupler 6 and the reset code disc 5 are used for determining the angle of the groove 3, so that the condition that the reaction cup is damaged due to the angle error is avoided.

The rotating shaft 1 and the mixing power part of each mixing mechanism are connected with synchronous wheels 7, each synchronous wheel 7 is commonly connected with a synchronous belt, the mixing power part is generally provided with a motor 4, the motor 4 drives the synchronous wheels 7 which are directly connected with the motor during operation to rotate, then the synchronous belt drives the corresponding step wheels 7 of the mixing mechanism to rotate, and then drives each mixing mechanism to synchronously rotate, and the rotation angle of each mixing mechanism is the same, namely, when the groove 3 of the connecting piece 2 at one mixing mechanism is in a state of being capable of entering and exiting a reaction cup, the connecting piece 2 of the corresponding mixing mechanism can also enter and exit the reaction cup, so that effective synchronization is realized, sustainable and effective operation of a detection device is ensured, namely, sustainable cleaning and luminous detection of each reaction cup on the turntable 8 are carried out.

Specifically described are: the application should also set up a plurality of take-up pulleys that are used for making the hold-in range keep tensioning state, generally realize through spring, support promotion connection in the take-up pulley of hold-in range, and this is common sense, and is not repeated here.

Additional description is: the reaction cup card is located the cup position of carousel 8, and the cup position of this embodiment sets up to the circular through-hole that the diameter is greater than the reaction cup diameter, and the reaction cup outer wall is provided with the protruding portion, and the protruding portion supports in the upper wall of carousel 8 for the reaction cup can't follow the cup position landing. When the mixing mechanism works, the reaction cup is driven to eccentrically rotate, and as the reaction cup is limited by the outline of the inner ring of the cup position, if the mixing mechanism is not positioned at the right center below the cup position, the outline of the inner ring of the cup position also gives a reaction force to the reaction cup, so that the reaction cup reciprocates along the groove 3, the movement complexity of the reaction cup is increased, and the mixing effect is improved; therefore, in the technical scheme of the application, the setting precision of the reset optocoupler 6 and the reset code disc 5 is not required to be too precise, and the mixing mechanism only needs to work to drive the reaction cup to rotate, so that the reaction cup is not damaged, and a good mixing effect can be generated; meanwhile, the production cost is reduced as higher precision is not needed.

Referring to fig. 1-3, a connecting piece 2 of a mixing mechanism is arranged below at least part of the liquid injection needle, four groups of cleaning components are arranged in the embodiment, and the reaction cup enters the cleaning device of the embodiment through a cup inlet 14 and is subjected to fourth-order cleaning; the turntable 8 drives the reaction cup to run clockwise, wherein the mixing mechanism is arranged below the positions of the second, third and fourth liquid injection needles 921, 931 and 941, and the mixing mechanism is not arranged below the position of the first liquid injection needle 911, and the reason is that: the magnetic block group 10 is not arranged between the cup inlet 14 and the first liquid injection needle 911, namely, the magnetic beads in the reaction cup are not gathered and are naturally in a discrete state, and a uniform mixing mechanism is not needed to break up the magnetic beads. In practice, if the mixing mechanism is arranged at the position, the effect of scattering the magnetic beads cannot be generated, but the stirring effect on the magnetic beads and the cleaning liquid still exists, so that the mixing effect is enhanced to a certain extent; however, considering that three subsequent cleaning steps still exist in the embodiment, the magnetic beads can be cleaned, so that the meaning of arranging the mixing mechanism is not great.

Referring to fig. 4, in this embodiment, four liquid injection needles are connected with a liquid injection plate 15, four liquid suction needles are connected with a liquid suction plate 16, the liquid injection plate 15 is located at the lower part of the liquid suction plate 16, and a abdication hole for the liquid suction needle to pass through is formed on the liquid injection plate 15; when the liquid is injected, the liquid injection plate 15 is controlled to move downwards to drive the four liquid injection needles to move downwards synchronously for liquid injection, and when the liquid is absorbed, the liquid absorption plate 16 is controlled to move downwards to drive the four liquid absorption needles to move downwards synchronously for liquid absorption, and the liquid injection plate 15 and the liquid absorption plate 16 are controlled by the lifting device at the side part to realize up-and-down movement, which is a conventional technical means and is not described in detail herein.

Referring to fig. 4, the filling mechanism 17 fills the excitation liquid into the reaction cup, and after the filling mechanism 17 and the detecting mechanism 12 are arranged on the fourth cleaning assembly, that is, after the reaction cup enters the detecting device, the reaction cup is cleaned by each cleaning assembly, and then the luminescence amount of the reaction cup is detected by the filled excitation liquid; the mixing mechanism is also arranged below the filling mechanism 17, and the purpose of the mixing mechanism is to mix the filled excitation liquid with the magnetic beads, so that the reaction is more complete, and the luminescence detection result is more accurate.

In the embodiment, the rotating shaft 1 and the mixing power part of the mixing mechanism are connected with synchronous wheels 7, the synchronous wheels 7 of the mixing mechanism at the lower parts of the second, third and fourth liquid injection needles 921, 931 and 941 are connected with the synchronous wheels 7 of one mixing power part through synchronous belts, and the synchronous wheels 7 of the mixing mechanism at the filling mechanism 17 are connected with the synchronous wheels 7 of the other mixing power part through synchronous belts; namely, the mixing mechanism at the cleaning assembly 9 works stably and synchronously, and the mixing mechanism at the excitation liquid filling position works stably and synchronously; the mixing force when the excitation liquid is injected can be different from that of the injection needle, the mixing force can be controlled independently, specifically, if the liquid amount in the reaction cup is large after the excitation liquid is injected, the rotating speed of the mixing power part is reduced, the liquid is prevented from splashing outside, and otherwise, the rotating speed is small.

The following describes in detail the process of transferring a cuvette in the detection device according to the present application with reference to fig. 1-4: firstly, a reaction cup enters a detection device through a cup inlet 14 under the action of an external clamp and is placed on a rotary table 8, the rotary table 8 moves to drive the reaction cup to move to the lower part of a first liquid injection needle 911, the first liquid injection needle 911 injects cleaning liquid into the reaction cup, and at the moment, magnetic beads in the reaction cup are not aggregated, so that the magnetic beads can be better washed and cleaned by the cleaning liquid; the magnetic block group 10 is arranged from the rear of the first liquid injection needle 911 to the position corresponding to the first liquid suction needle 912, namely, the rotary disk 8 rotates to pass through the lower part of the first liquid injection needle 911 and then is acted by the magnetic block group 10, the magnetic beads in the reaction cup start to gather, until the rotary disk 8 makes the reaction cup move to the lower part of the first liquid suction needle 912, the magnetic beads are completely adsorbed and gather, and the first liquid suction needle 912 pumps out the cleaning liquid in the reaction cup; then the rotary table 8 drives the reaction cup to move to the lower part of the second liquid injection needle 921, and when the second liquid injection needle 921 injects cleaning liquid into the reaction cup, the uniformly mixing mechanism at the lower part of the second liquid injection needle works to drive the reaction cup to eccentrically rotate so as to scatter magnetic beads gathered in the reaction cup, and the cleaning liquid and the magnetic beads are well mixed so as to realize cleaning; the operations of the fourth filling needle 941 are repeated completely and will not be described again; after the fourth filling needle 941 is filled with cleaning liquid, the height of the magnetic block group 10 is gradually reduced, so that the magnetic beads are gathered and adsorbed to the lower part of the reaction cup; until the reaction cup moves to the fourth liquid suction needle 942 to suck the cleaning liquid, the reaction cup continues to move to the lower part of the filling mechanism 17 and then is filled with the excitation liquid, a mixing mechanism is arranged at the lower part of the reaction cup, and the mixing mechanism works to break up the aggregated magnetic beads so as to enable the aggregated magnetic beads to fully react with the excitation liquid; when the reaction cup continues to move to the lower part of the measuring chamber 12, the cup jacking mechanism 11 works to jack up the reaction cup to the inside of the detecting mechanism 12, so that the detecting mechanism 12 can effectively detect the luminous quantity of the reaction cup. After the measurement is completed, the cup ejection mechanism 11 works reversely to reset the reaction cup, and when the reaction cup continues to move to the cup outlet 13 along with the turntable 8, the external clamp clamps the reaction cup out, so that the whole working flow of the reaction cup in the detection device of the embodiment is completed.

The foregoing is illustrative of the present utility model and is not to be construed as limiting thereof, but rather as providing for the use of additional embodiments and advantages of all such modifications, equivalents, improvements and similar to the present utility model are intended to be included within the scope of the present utility model as defined by the appended claims.

Claims (10)

1. A cleaning device, comprising:

a plurality of cup positions for accommodating the reaction cups are circumferentially distributed on the turntable;

the cleaning assemblies are sequentially distributed along the periphery of the turntable and comprise liquid injection needles and cleaning needles;

according to the cleaning sequence of the reaction cup, a plurality of magnet blocks with gradually reduced heights are arranged on one side of the cup position between the last group of liquid injection needles and the cleaning needles.

2. A cleaning device according to claim 1, wherein the magnet blocks are arranged in halbach arrays or multipole magnetic circuits or flux focusing structures.

3. A cleaning device according to claim 1, wherein the magnet block group is formed by combining one or more magnetic units, and a single magnet block group corresponds to a position of a reaction cup.

4. The cleaning device of claim 1, wherein a plurality of magnet blocks are disposed on one side of the cup between each set of the liquid injection needle and the cleaning needle.

5. The cleaning apparatus of claim 4, wherein the plurality of magnet blocks between each set of the filling needle and the cleaning needle are connected in sequence.

6. A cleaning device according to claim 1, wherein a mixing mechanism is provided under at least part of the filling needle.

7. The cleaning device according to claim 6, wherein the mixing mechanism comprises a rotating shaft, a mixing power part and a connecting piece; the rotating shaft is in transmission connection with the mixing power part, and the rotation center of the rotating shaft and the rotation center of the connected reaction cup are not in the same straight line.

8. The cleaning device according to claim 7, wherein the connecting piece is of a columnar structure coaxially fixed on the rotating shaft, the free end of the connecting piece is eccentrically provided with a groove for accommodating the reaction cup, the two transverse ends of the groove penetrate through the side part of the connecting piece, and the width of the groove is slightly larger than the outer diameter of the corresponding position of the reaction cup.

9. The cleaning device according to claim 7, wherein the output end of the rotating shaft or the mixing power part is connected with a reset code disc, one side of the reset code disc is provided with a reset optocoupler, and the reset code disc triggers the reset optocoupler to indicate the groove angle of the connecting piece to allow the reaction cup to enter and exit.

10. The cleaning device according to claim 7, wherein the rotating shafts and the mixing power parts are connected with synchronous wheels, and the synchronous wheels of the rotating shafts are connected with the synchronous wheels of the mixing power parts through synchronous belts.