CN107262472B - Cleaning disc of analyzer - Google Patents
Cleaning disc of analyzer Download PDFInfo
- Publication number
- CN107262472B CN107262472B CN201710498773.0A CN201710498773A CN107262472B CN 107262472 B CN107262472 B CN 107262472B CN 201710498773 A CN201710498773 A CN 201710498773A CN 107262472 B CN107262472 B CN 107262472B
- Authority
- CN
- China
- Prior art keywords
- magnetic pole
- reaction cup
- cup
- shaking
- analyzer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/083—Removing scrap from containers, e.g. removing labels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/38—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by using scrapers, chains, grains of shot, sand or other abrasive means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B2209/00—Details of machines or methods for cleaning hollow articles
- B08B2209/08—Details of machines or methods for cleaning containers, e.g. tanks
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to an analyzer cleaning disc, which attracts magnetic beads in a reaction cup through magnetic pole pairs positioned on two sides of a plurality of reaction cup running grooves, so that the magnetic beads are positioned on the front wall and the rear wall of the reaction cup, and the magnetic beads in the reaction cup cannot be attracted when being inserted into a liquid suction and injection needle in the reaction cup for sucking liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup move through the change of the magnetic poles to the N-S poles, so that the magnetic beads are further fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Description
Technical Field
The invention relates to a cleaning disc of an analyzer, and belongs to the technical field of medical instruments.
Background
Chemiluminescence immunoassay (CLIA) is a detection and analysis technique for various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and high specificity immunoreaction. It is usually necessary to coat specific biological materials on magnetic beads, and then add a luminescent solution to collect the luminescence intensity for quantitative analysis of the detection object.
The analyzer washs the dish and makes for realizing continuous measurement, and the reaction cup washs many times on a rotatory disc to will not wrap the biological raw materials of specificity on the magnetic bead and wash, current analyzer washs the dish cleaning performance not good, is taken away the magnetic bead by the washing liquid together easily moreover, thereby influences the measuring accuracy.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: in order to overcome the problems, the analyzer cleaning disc with a better cleaning effect is provided.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the invention provides a cleaning disc of an analyzer,
the method comprises the following steps:
a cylinder having a circular reaction cup running groove;
the disc is rotationally arranged in the cylinder, a circle of reaction cup accommodating holes are arranged on the disc in an equal-diameter mode, and the reaction cups can be placed in the reaction cup accommodating holes;
the magnetic pole groups are arranged in the cylinder in sequence along the running direction of the reaction cup, each magnetic pole group is composed of magnetic pole pairs positioned on two sides of the reaction cup running grooves, each magnetic pole group is at least provided with two magnetic pole pairs positioned on two sides of the reaction cup running grooves, the magnetic pole directions of the magnets in each magnetic pole pair in each magnetic pole group except the last magnetic pole group are the same, the magnetic pole directions of the adjacent two magnetic pole pairs are opposite, the magnetic pole directions of the magnets in each magnetic pole pair in the last magnetic pole group are the same or different, and the setting heights of the magnetic pole pairs are gradually reduced;
the liquid suction and injection positions of the liquid suction and injection needle are arranged at the position corresponding to the last magnetic pole pair of each magnetic pole group;
a shaking-up mechanism is arranged between the two magnetic pole groups.
Preferably, the analyzer of the present invention cleans the disk with the last pole pair in the last pole group being lowered in height by 5-8mm compared to the previous pole pair.
Preferably, the analyzer of the present invention cleans the disc, and the shaking mechanism includes: the device comprises a lifting driving piece, a lifting plate, a shaking driving piece fixed at the bottom of a cylinder, a rocker connected with the shaking driving piece through a coupler, an eccentric cup arranged at the top of the rocker, an elastic piece fixed on the cylinder and extending into the top of a disc, a cover wheel arranged on the elastic piece and used for covering the top of a reaction cup, a circular wheel capable of extending into the reaction cup, wherein the central axis of the eccentric cup is not collinear with the central axis of the rocker, when the reaction cup is shaken uniformly, the lifting plate is driven by the lifting driving piece to lift up the shaking driving piece, the rocker and the eccentric cup lift up along with the lifting plate, the eccentric cup jacks up the reaction cup, the top of the reaction cup is abutted against the cover wheel of the elastic piece, the reaction cup is fixed, then the shaking driving piece is started, the reaction cup is shaken by the eccentric cup, liquid in the reaction cup is shaken uniformly, a silicon rubber layer is arranged at the bottom of the cover wheel, and when the shaking driving piece, the reaction cup is rotated uniformly at the speed of 800-1200 rpm for 10-15s in one direction.
Preferably, the analyzer of the present invention cleans the disk with the distance between the central axis of the eccentric cup and the central axis of the rocking bar being 1/8-1/4 of the width of the reaction cup.
Preferably, the analyzer of the present invention cleans the disc, the eccentric cup of the shaking mechanism in front of the last magnetic pole group has magnetism, and the magnetic poles are located at the top and bottom ends.
Preferably, the analyzer of the present invention cleans the disk with 6 pole groups and 2 pole pairs per pole group.
Preferably, in the cleaning disc of the analyzer, in 6 magnetic pole groups, the magnetic pole directions of the magnetic pole pairs are N-S, N-S and S-N, S-N in sequence; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N.
The invention has the beneficial effects that: the magnetic beads in the reaction cup are attracted by the magnetic pole pairs positioned on the two sides of the running grooves of the reaction cup, so that the magnetic beads are positioned on the front wall and the rear wall of the reaction cup, and the magnetic beads in the reaction cup cannot be attracted when the magnetic beads are inserted into the reaction cup to suck liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup move through the change of the magnetic poles to the N-S poles, so that the magnetic beads are further fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Drawings
The invention is further illustrated by the following examples in conjunction with the drawings.
FIG. 1 is a perspective view of one embodiment of a reagent washing apparatus for an analyzer according to the present invention;
FIG. 2 is a schematic view of the magnetic pole arrangement on the disk of the present invention;
FIG. 3 is a perspective view of one embodiment of the wash plate mechanism of the present invention;
FIG. 4 is a perspective view of one embodiment of a shake-up mechanism of the present invention.
The reference signs are:
1-cylinder; 11-a reaction cup running groove; 2-a disc; (ii) a 3-shaking up the mechanism; 310-shaking up the driving member; 311-rocker; 321-an elastic sheet; 322-cover wheel; 330-eccentric cup; 900-reaction cup.
Detailed Description
The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic views illustrating only the basic structure of the present invention in a schematic manner, and thus show only the constitution related to the present invention.
Example 1
This embodiment provides an analyzer cleaning disk, as shown in fig. 1:
a cleaning disc mechanism, a liquid suction and injection mechanism and a shaking mechanism 3;
the cleaning disc mechanism includes:
a cylinder 1 having a circular reaction cup running groove 11;
the disc 2 is rotatably arranged in the cylinder 1, a circle of reaction cup accommodating holes are arranged on the disc 2 in an equal diameter mode, and the reaction cups 900 can be placed in the reaction cup accommodating holes;
a plurality of magnetic pole groups, which are arranged in the cylinder 1 and sequentially arranged along the running direction of the reaction cup 900 (for example, 6 magnetic pole groups are provided in fig. 1, and two magnetic pole pairs are a group), each magnetic pole group is composed of magnetic pole pairs positioned at two sides of the reaction cup running grooves 11, each magnetic pole group at least has two magnetic pole pairs positioned at two sides of the reaction cup running grooves 11, the magnetic pole direction of the magnet in each magnetic pole pair in each magnetic pole group is the same, and the magnetic pole direction of two adjacent magnetic pole pairs is opposite (for example, the magnetic pole direction of the magnetic pole pair is sequentially N-8652 zft 8652-S, S-N, S-N; N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N), the pole pair setting height of the last pole group is gradually reduced, and the height of the latter pole pair is reduced by 5-8mm compared with the height of the former pole pair;
shake even mechanism 3, lie in between two magnetic pole groups, include: a lifting driving part, a lifting plate, a shaking driving part 310 fixed at the bottom of the cylinder 1, a rocker 311 connected with the shaking driving part 310 through a coupling, an eccentric cup 330 arranged at the top of the rocker 311, an elastic sheet 321 fixed on the cylinder 1 and extending into the top of the disc 2, a cover wheel 322 arranged on the elastic sheet 321 and used for covering the top of the reaction cup 900, a round wheel capable of extending into the reaction cup 900 is arranged at the bottom of the cover wheel 322, the central axis of the eccentric cup 330 is not collinear with the central axis of the rocker 311, the distance between the central axis of the eccentric cup 330 and the central axis of the rocker 311 is 1/8-1/4 of the width of the reaction cup 900 (the distance is 2-2.5mm when the width of the reaction cup 900 is 1cm, otherwise, the liquid in the reaction cup 900 overflows due to large shaking amplitude), when the reaction cup 900 is shaken uniformly, the lifting plate is driven by the lifting driving part to rise, the shaking driving part 310, the rocker 311 and the eccentric cup 330 rise along with the lifting plate, the reaction cup 900 is jacked up by the eccentric cup 330 (the reaction cup 900 is not limited by the reaction cup accommodating hole 121), the top of the reaction cup 900 butts against the cover wheel 322 of the elastic sheet 321, the reaction cup 900 is fixed, then the shaking driving part 310 is started, the reaction cup 900 is shaken by the eccentric cup 330, the liquid in the reaction cup 900 is shaken uniformly, the silicon rubber layer is arranged at the bottom of the cover wheel 322, and when the reaction cup 900 is shaken uniformly, the reaction cup 900 is rotated by the shaking driving part 310 for 10-15s at the speed of 800-1200 revolutions per minute in one direction.
All magnets are neodymium boron iron magnets.
The eccentric cup 330 of the shaking-up mechanism 3 in front of the last magnetic pole group has magnetism, and the magnetic poles are positioned at the top and bottom ends.
In the disk type cleaning apparatus for an analyzer of this embodiment, the magnetic beads in the cuvette 900 are attracted by the pairs of magnetic poles located on both sides of the plurality of cuvette running grooves 11, and the magnetic beads are located on the front and rear walls of the cuvette 900, so that the magnetic beads in the cuvette 900 are not attracted when the pipette tips 4 inserted into the cuvette 900 suck liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup 900 are moved by the change of the N-S pole of each magnetic pole pair, so that the magnetic beads are fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Example 2
This embodiment provides an analysis appearance reagent storehouse body structure, as shown in fig. 1:
the difference of the magnetic pole direction of the last magnetic pole group is different from that of the embodiment 1, (such as the magnetic pole direction of the magnetic pole pair is S-N, S-N, S-N, S-N, N-S, N-S, N-S, N-S, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N, N-S, N-S, S-N, S-N in sequence), the magnetic pole pair setting height of the last magnetic pole group is gradually reduced, and the height of the next magnetic pole group is reduced by 5-8mm compared with the height of the previous magnetic pole group.
In light of the foregoing description of the preferred embodiments of the present invention, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (6)
1. An analyzer cleaning disc is characterized in that,
the method comprises the following steps:
a cylinder (1) having a circular reaction cup running groove (11);
the disc (2) is rotatably arranged in the cylinder (1), a circle of reaction cup accommodating holes are arranged on the disc (2) in an equal-diameter mode, and the reaction cups (900) can be placed in the reaction cup accommodating holes;
the magnetic pole groups are arranged in the cylinder (1) and are sequentially arranged along the running direction of the reaction cup (900), each magnetic pole group is composed of magnetic pole pairs positioned on two sides of the reaction cup running grooves (11), each magnetic pole group at least comprises two magnetic pole pairs positioned on two sides of the reaction cup running grooves (11), the magnetic pole directions of the magnets in each magnetic pole pair in each magnetic pole group except the last magnetic pole group are the same, the magnetic pole directions of two adjacent magnetic pole pairs are opposite, the magnetic pole directions of the magnets in each magnetic pole pair in the last magnetic pole group are the same or different, and the setting heights of the magnetic pole pairs are gradually reduced;
the liquid suction and injection positions of the liquid suction and injection needle (4) are arranged at the position corresponding to the last magnetic pole pair of each magnetic pole group;
a shaking-up mechanism (3) is arranged between the two magnetic pole groups;
shake even mechanism (3) and include: a lifting driving piece, a lifting plate, a shaking uniformly driving piece (310) fixed at the bottom of the cylinder (1), a rocker (311) connected with the shaking uniformly driving part (310) through a coupler, an eccentric cup (330) arranged at the top of the rocker (311), an elastic sheet (321) fixed on the cylinder (1) and extending into the top of the disc (2), a cover wheel (322) used for covering the top of the reaction cup (900) is arranged on the elastic sheet (321), a round wheel capable of extending into the reaction cup (900) is arranged at the bottom of the cover wheel (322), the central axis of the eccentric cup (330) is not collinear with the central axis of the rocker (311), when the reaction cup (900) is shaken up, the lifting driving piece drives the lifting plate to rise, the shaking driving piece (310), the rocker (311) and the eccentric cup (330) rise along with the lifting plate, the eccentric cup (330) jacks up the reaction cup (900), the top of the reaction cup (900) is propped against the cover wheel (322) of the elastic sheet (321), the reaction cup (900) is fixed, then the shaking driving piece (310) is started, the reaction cup (900) is shaken by the eccentric cup (330), so that the liquid in the reaction cup (900) is shaken uniformly, the silicon rubber layer is arranged at the bottom of the cover wheel (322), when the liquid is shaken uniformly, shaking the driving member (310) to rotate the reaction cup (900) in one direction at a speed of 800-1200 rpm for 10-15s.
2. The analyzer cleaning disk of claim 1 wherein the subsequent pole pair in the last pole group is reduced in height by 5-8mm compared to the previous pole pair.
3. The analyzer cleaning disk according to claim 2, wherein the distance between the central axis of the eccentric cup (330) and the central axis of the rocking lever (311) is 1/8 to 1/4 of the width of the reaction cup (900).
4. The analyzer washing tray according to claim 2 or 3, characterized in that the eccentric cup (330) of the shaking mechanism (3) in front of the last pole group is magnetic, and the poles are located at the top and bottom ends.
5. The analyzer wash plate of claim 2 or 3 wherein there are 6 pole groups and 2 pole pairs per pole group.
6. The analyzer cleaning disk according to claim 5, wherein in 6 magnetic pole groups, the magnetic pole pair magnetic pole directions are sequentially N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498773.0A CN107262472B (en) | 2017-06-27 | 2017-06-27 | Cleaning disc of analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498773.0A CN107262472B (en) | 2017-06-27 | 2017-06-27 | Cleaning disc of analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107262472A CN107262472A (en) | 2017-10-20 |
| CN107262472B true CN107262472B (en) | 2023-04-18 |
Family
ID=60068443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710498773.0A Active CN107262472B (en) | 2017-06-27 | 2017-06-27 | Cleaning disc of analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107262472B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110586557B (en) * | 2019-09-11 | 2021-08-20 | 苏州长光华医生物医学工程有限公司 | Cleaning and separating device |
| CN113787070B (en) * | 2021-11-17 | 2022-02-08 | 南京万承生物科技有限公司 | Dynamic cleaning station of chemiluminescence immunoassay analyzer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203426088U (en) * | 2013-08-22 | 2014-02-12 | 钟伟明 | Magnetic bead washing device |
| CN103599898B (en) * | 2013-10-29 | 2015-11-25 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device |
| CN203764601U (en) * | 2014-04-11 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Magnetic microsphere cleaning device used for fully automatic chemiluminescence immunity analyzer |
| CN105891113A (en) * | 2014-12-16 | 2016-08-24 | 合肥运涛光电科技有限公司 | Reaction vessel for luminescence tester and cleaning and separating mechanism thereof |
| CN104655831A (en) * | 2015-03-04 | 2015-05-27 | 哈尔滨工业大学（威海） | Magnetic bead cleaning and separating device for full-automatic chemical luminescence immunity analyzer |
| CN207154340U (en) * | 2017-06-27 | 2018-03-30 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer cleans disk |
-
2017
- 2017-06-27 CN CN201710498773.0A patent/CN107262472B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107262472A (en) | 2017-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107252793B (en) | Disc type cleaning device for analyzer | |
| CN107262444B (en) | A kind of analyzer magnetic bead cleaning method | |
| CN102753972B (en) | Relate to the assay method and device that use magnetic-particle | |
| KR20190104193A (en) | Automatic analysis device and sample analysis method | |
| CN102565438B (en) | Reaction cuvette | |
| CN206339561U (en) | Small electrical chemical illumination immunity analysis instrument | |
| KR20190103293A (en) | Reaction culture apparatus, immunoassay and reaction culture method | |
| CN107262472B (en) | Cleaning disc of analyzer | |
| WO2020062946A1 (en) | Magnetic bead cleaning device and chemiluminescence immunoassay analyzer | |
| CN106018784A (en) | Small electrochemical luminescence immunoassay analyzer and analysis method thereof | |
| CN103760373B (en) | Cleaning device in fully-automatic chemiluminescence immunity analyzer | |
| CN116840499A (en) | Automatic analysis device and sample analysis method thereof | |
| CN104722526A (en) | Magnetism separating device | |
| CN110146712B (en) | Rotary sampling miniature turntable type full-automatic luminous immunoassay system | |
| US20220128550A1 (en) | Apparatuses and methods for mixing fluid or media by vibrating a pipette using transient and steady-state intervals | |
| CN108107227A (en) | A kind of chemiluminescence immune assay chip cartridges and operating method | |
| CN203764601U (en) | Magnetic microsphere cleaning device used for fully automatic chemiluminescence immunity analyzer | |
| CN208082677U (en) | Automatic cleaning separator | |
| JP2018510363A (en) | Apparatus and method for floating and washing the contents of multiple cuvettes | |
| CN110346586A (en) | Full-automatic detection apparatus | |
| CN103920675A (en) | Magnetic microsphere cleaning device for full-automatic chemiluminescent immunoassay instrument | |
| WO2016043291A1 (en) | Method for cleaning magnetic carrier particles, device for cleaning magnetic carrier particles, and immunoassay method using magnetic carrier particles | |
| CN207154340U (en) | A kind of analyzer cleans disk | |
| CN110823669A (en) | Magnetic separation cleaning method | |
| CN204544866U (en) | A kind of magnetic separating device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |