CN208082677U - Automatic cleaning separator - Google Patents
Automatic cleaning separator Download PDFInfo
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- CN208082677U CN208082677U CN201820683436.9U CN201820683436U CN208082677U CN 208082677 U CN208082677 U CN 208082677U CN 201820683436 U CN201820683436 U CN 201820683436U CN 208082677 U CN208082677 U CN 208082677U
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- magnetic
- turntable
- magnetic field
- automatic cleaning
- accommodating body
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Abstract
The utility model is related to a kind of automatic cleaning separators, the main points of its technical scheme are that, including：Disc components, including accommodating body and the turntable in the accommodating body, the turntable is for storing reaction vessel；Magnetic field generation mechanisms, set on the turntable periphery or inside, for providing magnetic field environment into the accommodating body, the magnetic field generation mechanisms include at least a magnet unit, the magnet unit includes at least a magnetic part pair, and the polarity on two magnetic parts towards the accommodating side of the magnetic part centering is opposite；And rotary drive assembly, for driving the turntable to rotate so that the reaction vessel passes through the magnetic field environment；Have the advantages that keep magnetic particle assemble index short and efficient.
Description
Technical field
The utility model is related to the technical fields that in-vitro diagnosis automates immunoassay equipment, more particularly to a kind of automatic
Clean separator.
Background technology
Automatic chemiluminescence immunoassay is an important technology of in-vitro diagnosis automated analysis, which mainly leads to
Over cleaning separator and detection device are completed.Wherein, first with cleaning separator by sample target substance and its
He detaches substance, recycles detection device to carry out signal reaction, analysis to the target substance isolated, obtains diagnosing required
Indices parameter.
A kind of known cleaning separator injects the reagent containing magnetic particle into sample when using, this, which contains, is magnetic
Target substance in the reagent and sample of particle, which reacts, generates immune complex, and remainder unreacted reactant is gone back in sample；
Above-mentioned immune complex is captured reaction vessel inner wall by the magnetic force then provided by single permanent magnet；It is injected to reaction vessel
The liquid in reaction vessel is drawn after cleaning solution, above-mentioned unreacted reactant is sucked away at this time, leaves capture in reaction vessel inner wall
Immune complex.The step of can carrying out luminescence-producing reaction and analysis to the immune complex after separation later.
However the above-mentioned prior art by immune complex during capturing reaction vessel inner wall that there are magnetic particles
Assemble index grows the problem low with efficiency, so that influencing the sample process ability and analytical effect of global analysis instrument.
Utility model content
Based on this, it is necessary to there is a problem of that magnetic particle assemble index length is low with efficiency for the prior art, provide one
The automatic cleaning separator of kind, has the advantages that magnetic particle assemble index is short and efficient.
A kind of automatic cleaning separator, including：
Disc components, including accommodating body and the turntable being rotatably dispose in the accommodating body, the turntable is for storing instead
Answer container；
Magnetic field generation mechanisms are set to the turntable periphery or inside, for providing magnetic field environment into the accommodating body, institute
It states magnetic field generation mechanisms and includes at least a magnet unit, the magnet unit includes at least a magnetic part pair, the magnetism
The polarity of two magnetic parts towards the turntable side of part centering is opposite；And
Rotary drive assembly, for driving the turntable to rotate so that the reaction vessel passes through the magnetic field environment.
Two magnetic parts of the magnetic part centering are arranged along the short transverse of the accommodating body in one of the embodiments,
Cloth.
The magnet unit further includes at least one independent magnet part, the independent magnet in one of the embodiments,
Part is with the magnetic part to the rotation direction arrangement along the turntable.
The magnet unit includes three magnetic parts pair in one of the embodiments,.
The first place of magnetic field generation mechanisms described in the rotation direction along the turntable is the magnetic in one of the embodiments,
Property part pair.
The independent magnet part is located at along either one or two of rotation direction of turntable magnetism in one of the embodiments,
Part is to rear.
In one of the embodiments, there are three the magnet units, three magnet units turn along the turntable
Dynamic direction is set gradually.
The magnetic part in the magnet unit is cuboid or cylinder in one of the embodiments,.
The magnet unit is fixed on the accommodating body in one of the embodiments,.
The magnetic part in the magnetic field generation mechanisms is permanent magnet in one of the embodiments,.
Above-mentioned automatic cleaning separator provides magnetic field environment by magnetic field generation mechanisms, and disc components include accommodating body
With the turntable in accommodating body, the turntable is for storing reaction vessel, for holding with magnetic particle in the reaction vessel
Solution, rotary drive assembly for driving disc rotate so that reaction vessel pass through magnetic field environment；Due to magnetic field generation mechanisms
A magnetic part pair is included at least, two magnetic parts direction of the magnetic part centering houses the polarity on side on the contrary, two magnetic
Property part between form stable magnetic field, and two magnetic parts cooperate by magnetic field it is regular be strip so that magnetic field side
To more preferably unified, magnetic intensity is improved, and then under the action of magnetic field after the integration, the movement velocity of magnetic particle is more
Soon, the direction of motion is more preferably unified, so that magnetic particle assemble index is shorter, it is more efficient.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of automatic cleaning separator in the utility model embodiment；
Fig. 2 is the structural schematic diagram of the disc components and magnetic field generation mechanisms in the utility model embodiment；
Fig. 3 is the sectional view of disc components in the utility model embodiment, in order to illustrate the arrangement of magnetic part pair；
Fig. 4 is the sectional view at another visual angle of disc components in the utility model embodiment, in order to illustrate independent magnet part
Position.
Reference numeral：100, disc components；110, bottom plate；120, accommodating body；130, turntable；131, shaft；132, it is incubated
Slot；133, separating tank is cleaned；140, disk cover；141, imbibing hole；142, liquid injection hole；200, rotary drive assembly；210, motor；
220, belt；300, magnetic field generation mechanisms；310, the first magnet unit；320, the second magnet unit；330, third magnet unit；
340, magnetic part pair；350, independent magnet part；400, mixing component is cleaned；410, fluid injection needle tubing；420, imbibition needle tubing；500, anti-
Answer container.
Specific implementation mode
The utility model is described more fully referring to relevant drawings for the ease of understanding the utility model,.
The utility model preferred embodiment is given in attached drawing.But the utility model can be realized in many different forms, and
It is not limited to embodiment described herein.Make the utility model disclosure on the contrary, purpose of providing these embodiments is
Understand more preferably thorough and comprehensive.
It should be noted that when element is referred to as " being fixed on " another element, it can be directly on another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be directly connected to
To another element or it may be simultaneously present centering elements.
A kind of automatic cleaning separator, for containing target substance and magnetic particles in the sample in reaction vessel 500
The compound of son is detached with other substances other than compound, to remove other substances in sample other than compound,
The magnetic particle can be oriented movement under the influence of a magnetic field.
Referring to Fig. 1 and Fig. 2, automatic cleaning separator provided in this embodiment includes disc components 100, rotation driving group
Part 200, the magnetic field generation mechanisms 300 for providing magnetic field environment, and cleaning mixing component 400.Wherein, on disc components 100
It is placed with reaction vessel 500, cleaning mixing component 400 is arranged in 100 top of disc components, and magnetic field generation mechanisms 300 are arranged in
100 periphery of disc components.
In use, the reaction vessel 500 of the reagent by sample is filled and containing magnetic particle is placed on disc components 100
On, the target substance and magnetic particle reaction generation immune complex in sample in reaction vessel 500.Rotary drive assembly
200 driving disc components 100 rotate, to drive reaction vessel 500 to enter the magnetic field environment that magnetic field generation mechanisms 300 generate,
And it is aligned with 400 position of cleaning mixing component；Cleaning mixing component 400 injects cleaning buffer solution into reaction vessel 500,
Remaining unreacted reactant is cleaned 400 absorption of mixing component and removes out reaction vessel 500 again in sample.Utilize cleaning mixing component
400 draw the partially liq (imbibition process) containing unreacted reactant in reaction vessel 500, are then injected into new cleaning solution (note
Liquid process), imbibition and injection process is repeated, to leave immune complex in reaction vessel 500.
It will be understood by those skilled in the art that the device of the utility model is completed to note for matching purge mixing component 400
Liquid and imbibition also relate to fluid devices such as syringe (pump), imbibition peristaltic pump (or vacuum pump), fluid circuit and relevant
Circuit, software controlled unit, these are technology generally in the art, and the utility model is not discussed in detail.
Specifically, referring to Fig. 1 and Fig. 2, disc components 100 include bottom plate 110 and the accommodating body on bottom plate 110
120, accommodating body 120 is preferably fireless cooker in the present embodiment.Disc components 100 further include the turntable being set in accommodating body 120
130, and the disk cover 140 that is placed on accommodating body 120.Turntable 130 is used for placing response container 500.Turntable 130 is equipped with several
Incubation slot 132 and cleaning separating tank 133；Wherein, incubation slot 132 is arranged on turntable 130 in inner ring, is specially in the present embodiment
Three circle arrangements, cleaning separating tank 133 are arranged on turntable 130 in outer ring；The incubation slot 132 is for placing the reaction being incubated
The reaction vessel 500 being positioned in incubation slot 132 after the completion of incubation process, is moved to above-mentioned cleaning separating tank by container 500
Cleaning separation process is carried out in 133, to remove the ingredient being not associated in reactant.The bottom centre of turntable 130 is provided with shaft
131, which is pierced by accommodating body 120.
Rotary drive assembly 200 is arranged in 100 lower section of disc components.Rotary drive assembly 200 includes being fixed on bottom plate 110
On motor 210 and linkage 210 output shaft of motor and shaft 131 belt 220, the rotary drive assembly 200 is for driving institute
Turntable 130 is stated to rotate so that the reaction vessel 500 passes through magnetic field environment.
Referring to Fig. 1 and Fig. 2, the cleaning mixing component 400 provided in the present embodiment is arranged in 100 top of disc components.Clearly
It is not to be completely covered in the top of disc components 100 to wash mixing component 400, the tops of disc components 100 still have part not by
Clean the region of 400 covering of mixing component.Reaction vessel 500 can be taken from disc components 100 in the uncovered region
Go out or is placed in disc components 100.It includes fluid injection plate, fluid injection plate lifting motor, three notes to clean mixing component 400 mainly
Liquid needle tubing 410, imbibition plate, imbibition motor, three imbibition needle tubings 420 etc..Referring to Fig. 2, several imbibing holes are provided on disk cover 140
141 and several liquid injection holes 142, liquid injection hole 142 is corresponding with the cleaning fluid injection needle tubing 410 of mixing component 400, for completing fluid injection
Process, imbibing hole 141 is corresponding with the cleaning imbibition needle tubing 420 of mixing component 400, for completing imbibition process.
Referring to Fig. 2, which includes the first magnet unit 310, the second magnet unit 320 and third magnetic
Body unit 330, above three magnet unit (the first magnet unit 310, the second magnet unit 320 and third magnet unit 330)
Rotation direction along turntable 130 is arranged successively；In the present embodiment, each magnet unit includes three magnetic parts pair 340 and one
A independent magnet part 350, (above-mentioned magnetic part pair 340 is set up in parallel by two independent magnet parts 350, will be independent in the present embodiment
Magnetic part 350 is referred to as magnetic part), and arranged successively as magnetic part pair 340, magnetic part pair along the rotation direction of turntable 130
340, magnetic part pair 340 and independent magnet part 350；In other embodiments, independent magnet part 350 can also be located above three
The rear of any one in magnetic part pair 340, rear here refers to along the rear of the rotation direction of the turntable 130, also
It is to say, along the rotation direction of the turntable 130, the first place of the magnetic field generation mechanisms 300 is magnetic part pair 340.The present embodiment
In magnetic part be cuboid, those skilled in the art can be substituted rectangular in the present embodiment with the magnetic part of other shapes
Body magnetic part, to reach identical function, such as magnetic part is square or cylinder and other gengons.
Above-mentioned magnetic field generation mechanisms 300 can be fixed on accommodating body 120, which makes reaction vessel
Magnetic particle in 500 moves to 500 inner wall of reaction vessel along magnetic direction.Due to magnetic particle in magnetic field movement speed,
The factors such as displacement distance and resistance, magnetic particle are adsorbed onto 500 inner wall of reaction vessel and need the regular hour, usually arrive within several seconds
It differs within tens seconds, so every time before imbibition, reaction vessel 500 is needed by magnetic field environment for a period of time.In other embodiment
In, which can not also contact with accommodating body 120, such as can be fixed by an external support mechanism
The magnetic field generation mechanisms 300 are to provide magnetic field environment.In other embodiments, magnetic field generation mechanisms 300 also can be disposed at disk body
The inside of component 100, such as cleaning separating tank 133 are arranged and are arranged in 130 outer ring of turntable in the inner ring of turntable 130, incubation slot 132
When, magnetic field generation mechanisms 300 are arranged in the inside of disc components 100.
Referring to Fig. 3, two magnetic parts in above-mentioned magnetic part pair 340 towards 130 side of turntable polarity on the contrary, each magnetic
As long as arrangement mode of two magnetic parts in 130 periphery of turntable in part pair 340 meets two above-mentioned magnetic parts towards turntable
The polarity of 130 sides is on the contrary, it is preferred that the height of two magnetic parts in the magnetic part pair 340 along the accommodating body 120
It arranges in direction.In the present embodiment, the magnetic part that is located above towards 120 side of accommodating body be N grades, underlying magnetic part direction
120 side of accommodating body is S grades, and the bar shaped magnetic field stablized and reinforced is formd between N grades and S grades.Certainly, the magnetic part being located above
It it is S grades towards 120 side of accommodating body, underlying magnetic part is N grades towards 120 side of accommodating body can also reach identical effect
Fruit.In conjunction with Fig. 4, independent magnet part 350 is N grades towards 120 side of accommodating body, and certainly, the independent magnet part 350 is towards accommodating body
120 sides are S grades and also may be used.
In other embodiments, above three magnet unit can include at least a magnetic part pair 340；In other realities
It applies in example, above three magnet unit can include at least a magnetic part pair 340 and an independent magnet part 350, described
Rotation direction of the independent magnet part 350 with the magnetic part pair 340 along the turntable 130 is arranged.
The magnetic part in magnetic field generation mechanisms 300 in the present embodiment is permanent magnet, certainly in other embodiments, the magnetic
Property part may be electromagnet.
It completes in use, a period of time will be incubated in the incubation slot 132 on turntable 130 or be incubated and needs to clean separation
Reaction vessel 500 is transferred on cleaning separating tank 133, and reaction vessel 500 is transported to cleaning mixing component by the rotation of turntable 130
400 lower sections, simultaneous reactions container 500 also enter the field region of magnetic field generation device.Magnetic particle in reaction vessel 500
Just gradually assemble to 500 inner wall of reaction vessel close to 300 side of magnetic field generation mechanisms under magnetic field environment, reaction vessel 500
The first rank imbibition process and the first rank injection process are completed in the magnetic field environment of the first magnet unit 310, specifically, when reaction
When container 500 is reached below the first rank liquid injection hole 142a, start the first rank injection process；After the completion of first rank injection process, turn
Disk 130 drives one position of the advance of reaction vessel 500, and the operating of reaction vessel 500 that will complete the first rank fluid injection reaches the first rank
Below imbibing hole 141a, start the first rank imbibition process of the reaction vessel 500.Similar, reaction vessel 500 is successively second
Second-order injection process and second-order imbibition process are completed in the magnetic field environment of magnet unit 320, reaction vessel 500 is in third magnetic
Third rank injection process and the imbibition of third rank and subsequent signal reagent fluid injection are completed in the magnetic field environment of body unit 330
Journey, i.e. reaction vessel 500 reach second-order liquid injection hole 142b, second-order imbibing hole 141b and third rank liquid injection hole successively
142c, third rank imbibing hole 141c, signal reagent liquid injection hole lower section, complete subsequent suction, fluid injection and signal reagent fluid injection.
The first rank fluid injection and the first rank imbibition process are in the magnetic field environment that the first magnet unit 310 provides in the present embodiment
It completes, substantially can complete to divide immune complex and unreacted reactant in the sample in reaction vessel 500 at this time
From, other substances in removal sample other than immune complex, but there are still detach halfway situation；By further setting
Set second-order fluid injection and second-order imbibition process and the fluid injection of third rank and third rank imbibition process so that more preferably thoroughly complete
Immune complex and unreacted reactant are detached in sample in pairs of reaction vessel 500, remove in sample immune complex with
Other outer substances.In above-mentioned technical proposal, being designed to provide for independent magnet part 350 is set up in each magnet unit
One section of magnetism is weaker and magnetic field compared with integrated distribution, so that the magnetic particle in reaction vessel 500 more preferably can uniformly be assembled
In the inner wall of reaction vessel 500, the cleaning in favor of cleaning mixing component 400 and mixing.Certainly, in other embodiments,
The independent magnet part 350 in above-mentioned technical proposal can be replaced with magnetic part pair 340, that is, is not provided with independent magnet part 350.
In conclusion above-mentioned automatic cleaning separator provides magnetic field environment, disc components by magnetic field generation mechanisms 300
100 include accommodating body 120 and the turntable 130 in accommodating body 120, and for the turntable 130 for storing reaction vessel 500, this is anti-
Answer for holding the solution with magnetic particle in container 500, rotary drive assembly 200 rotated for driving disc 130 so that
Reaction vessel 500 passes through magnetic field environment；Since magnetic field generation mechanisms 300 have included at least a magnetic part pair 340, the magnetic part
To two magnetic parts in 340 towards the polarity of 120 side of accommodating body on the contrary, form stable magnetic field between two magnetic parts,
And two magnetic parts mutual cooperation magnetic direction is carried out it is regular so that magnetic direction is more preferably same, improves magnetic intensity,
And then under the action of magnetic field after the integration, faster, the direction of motion is more preferably unified for the movement velocity of magnetic particle, so that
Magnetic particle assemble index is shorter, more efficient.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed,
But therefore it can not be interpreted as the limitation to utility model patent range.It should be pointed out that for the common skill of this field
For art personnel, without departing from the concept of the premise utility, various modifications and improvements can be made, these are belonged to
The scope of protection of the utility model.Therefore, the protection domain of the utility model patent should be determined by the appended claims.
Claims (10)
1. a kind of automatic cleaning separator, which is characterized in that including：
Disc components (100), including accommodating body (120) and the turntable (130) that is rotatably dispose in the accommodating body (120), institute
Turntable (130) is stated for storing reaction vessel (500)；
Magnetic field generation mechanisms (300) are set to the turntable (130) periphery or inside, for being provided into the accommodating body (120)
Magnetic field environment, the magnetic field generation mechanisms (300) include at least a magnet unit, and the magnet unit includes at least a magnetic
For property part to (340), the magnetic part is opposite to the polarity of two magnetic parts in (340) towards the turntable (130) side；And
Rotary drive assembly (200), for driving the turntable (130) to rotate so that described in the reaction vessel (500) process
Magnetic field environment.
2. automatic cleaning separator according to claim 1, which is characterized in that the magnetic part is to two in (340)
A magnetic part is arranged along the short transverse of the accommodating body (120).
3. automatic cleaning separator according to claim 2, which is characterized in that the magnet unit further includes at least one
A independent magnet part (350), the independent magnet part (350) is with the magnetic part to (340) along the rotation of the turntable (130)
It arranges in direction.
4. automatic cleaning separator according to claim 3, which is characterized in that the magnet unit includes three magnetism
Part is to (340).
5. automatic cleaning separator according to claim 3, which is characterized in that the rotation side along the turntable (130)
To the first place of the magnetic field generation mechanisms (300) be the magnetic part to (340).
6. automatic cleaning separator according to claim 3, which is characterized in that the independent magnet part (350) is located at
Along the turntable (130) rotation direction any one magnetic part to (340) rear.
7. the automatic cleaning separator according to claim 1-6 any one, which is characterized in that the magnet unit has
Three, three magnet units are set gradually along the rotation direction of the turntable (130).
8. the automatic cleaning separator according to claim 1-6 any one, which is characterized in that in the magnet unit
Magnetic part be cuboid or cylinder.
9. the automatic cleaning separator according to claim 1-6 any one, which is characterized in that the magnet unit is solid
Due to the accommodating body (120).
10. the automatic cleaning separator according to claim 1-6 any one, which is characterized in that the magnetic field generates
Magnetic part in mechanism (300) is permanent magnet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820683436.9U CN208082677U (en) | 2018-05-08 | 2018-05-08 | Automatic cleaning separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820683436.9U CN208082677U (en) | 2018-05-08 | 2018-05-08 | Automatic cleaning separator |
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| Publication Number | Publication Date |
|---|---|
| CN208082677U true CN208082677U (en) | 2018-11-13 |
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ID=64053007
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820683436.9U Active CN208082677U (en) | 2018-05-08 | 2018-05-08 | Automatic cleaning separator |
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| Country | Link |
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| CN (1) | CN208082677U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111381054A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
| CN111381056A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
| WO2020215175A1 (en) * | 2019-04-22 | 2020-10-29 | 深圳迈瑞生物医疗电子股份有限公司 | Magnetic bead reagent uniform mixing apparatus, uniform mixing method, and sample analysis device |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
-
2018
- 2018-05-08 CN CN201820683436.9U patent/CN208082677U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111381054A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
| CN111381056A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
| CN111381056B (en) * | 2018-12-29 | 2024-03-01 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer and flow type fluorescence immunoassay analyzer |
| WO2020215175A1 (en) * | 2019-04-22 | 2020-10-29 | 深圳迈瑞生物医疗电子股份有限公司 | Magnetic bead reagent uniform mixing apparatus, uniform mixing method, and sample analysis device |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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