CN109917145B - Full-automatic chemiluminescence immunoassay instrument - Google Patents
Full-automatic chemiluminescence immunoassay instrument Download PDFInfo
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- CN109917145B CN109917145B CN201711319733.1A CN201711319733A CN109917145B CN 109917145 B CN109917145 B CN 109917145B CN 201711319733 A CN201711319733 A CN 201711319733A CN 109917145 B CN109917145 B CN 109917145B
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Abstract
A full-automatic chemiluminescence immunoassay analyzer, comprising: the device comprises a rack, an analysis part and a control part, wherein the analysis part is arranged on the rack, the control part is used for controlling the operation of the analysis part, and the control part is used for controlling the analysis part to perform full-automatic chemiluminescence immunoassay. The analysis unit includes: sampling system, sample reagent dish, wash pond, incubation cleaning system, reaction cup loading system, reaction cup transfer system and optical detection system, sample reagent dish include drive assembly, disk body, and the disk body distributes along the circumferencial direction has the cavity that bears kit and sample pipe, incubate cleaning system including being concentric circles setting incubate dish and wash the dish, incubate dish and wash the independent drive of dish. Through the design of complete machine overall arrangement and the integrated design of functional module, above-mentioned full automatization chemiluminescence immunoassay appearance is small, degree of automation is high, detection speed is fast, the precision is high, simple structure, easy and simple to handle.
Description
Technical Field
The invention belongs to the technical field of chemiluminescent immunoassay, and particularly relates to a full-automatic chemiluminescent immunoassay instrument.
Background
The magnetic particle type chemiluminescence immunoassay has the advantages of high sensitivity, strong specificity, wide linear range, high automation degree and the like, and becomes a main means of clinical diagnosis. However, due to the complexity of the apparatus, the full-automatic chemiluminescent immunoassay analyzer is relatively large in size and high in cost, and is not suitable for application in specific occasions. If the miniaturization treatment is required, only partial automatic functions of the instrument can be sacrificed, and full-automatic treatment cannot be achieved. After sacrificing the automation degree, the added manual operation steps of the user can reduce the measurement accuracy of the chemiluminescent analyzer due to uncertainty such as manual operation errors, operation specifications and the like.
Disclosure of Invention
Based on this, it is necessary to provide a full-automatic chemiluminescence immunoassay analyzer with smaller product size and higher measurement accuracy.
A full-automatic chemiluminescence immunoassay analyzer, comprising: a frame, an analysis part arranged on the frame and a control part for controlling the operation of the analysis part; the analysis unit includes:
the sampling system comprises a sampling driving assembly, a sampling arm connected with the driving assembly and a sampling needle arranged at one end of the sampling arm;
a sample reagent tray for storing and dispensing the reagent kit and the sample tube;
the cleaning pool is arranged on the motion trail of the sampling needle for sampling and is used for cleaning the sampling needle;
the incubation cleaning system comprises an incubation tray and a cleaning tray, wherein the incubation tray and the cleaning tray are arranged in concentric circles, the incubation tray is arranged on an outer ring, the cleaning tray is arranged on an inner ring, the incubation tray and the cleaning tray are independently driven, the incubation tray comprises an incubation tray body for incubating samples in a reaction cup, an incubation driving assembly for driving the incubation tray body to operate, and a heating assembly for controlling the temperature of the incubation tray and the cleaning tray, the cleaning tray is used for carrying out multistage cleaning on magnetic particles in the reaction cup, an injection liquid mixing assembly and a liquid absorbing assembly positioned on one side of the injection liquid mixing assembly are arranged on the cleaning tray along the circumferential direction, a cleaning tray driving assembly for driving the cleaning tray is arranged on the side of the cleaning tray, and the injection liquid mixing assembly is used for injecting cleaning liquid into the reaction cup and uniformly mixing the samples in the reaction cup after incubation of the incubation tray body, and the liquid absorbing assembly is used for absorbing liquid after solid-liquid separation in the reaction cup;
the reaction cup loading system is used for loading the reaction cup;
the reaction cup transfer system is connected with the reaction cup loading system and comprises a grabbing mechanism for grabbing the reaction cup and a motion control system for controlling the reaction cup to transfer among the incubation plate, the cleaning plate and the reaction cup loading system;
and the optical detection system is connected to the outer side of the incubation disc and comprises an optical counting device for reading detection result signals.
The control part is electrically connected with the sampling system, the sample reagent disk, the cleaning pool, the incubation cleaning system, the reaction cup loading system, the reaction cup transferring system and the optical detection system.
In one embodiment, the device further comprises a bar code scanning system positioned on the outer side of the sample reagent disk, wherein the bar code scanning system comprises a scanner for scanning bar codes of the sample tube and bar code information of the reagent kit, and a bar code card slot is arranged on a light path between the scanner and the sample reagent disk.
In one embodiment, the injection mixing assembly is provided with a plurality of injection needles, and the imbibing assembly is provided with a plurality of imbibing needles.
In one embodiment, the cuvette loading system comprises a guide rail arranged obliquely and a cuvette carrying structure positioned on the guide rail.
In one embodiment, the sample reagent disk comprises a drive assembly and a disk body, wherein the drive assembly is used for driving the disk body to rotate; the tray body is distributed with the cavity that bears kit and sample pipe along circumferencial direction, the tray body top is equipped with inhales the appearance mouth, the sampling needle motion extremely inhale the sample in the reagent and the sample pipe in the kit of appearance mouth.
In one embodiment, a plurality of the kits and a plurality of the sample tubes are distributed on the tray.
In one embodiment, the sample reagent tray includes an outer pot surrounding the tray body and capable of refrigerating the reagent cartridge and sample tube carried on the tray body.
In one embodiment, the sampling needle is a rotary sampling needle, and the sampling drive assembly drives the sampling needle to rotate in the horizontal direction and move in the vertical direction so as to suck the sample or the reagent, and the sample or the reagent is discharged into the reaction cup.
In one embodiment, the sampling needle is a linear sampling needle, and the sampling driving assembly drives the sampling needle to translate in the horizontal direction and the vertical direction so as to suck the sample or the reagent, and the sample or the reagent is discharged into the reaction cup.
In one embodiment, the cuvette handling system comprises a filling mechanism for filling the cuvette with a liquid.
In the full-automatic chemiluminescence immunoassay analyzer, through the concentric design of the incubation plate and the cleaning plate, the coaxial but independent driving is realized, and the structure is more compact, the instrument volume is smaller, and the weight is lighter under the function of independent movement. Through the design of complete machine overall arrangement and the integrated design of functional module, above-mentioned full automatization chemiluminescence immunoassay appearance has small, degree of automation is high, detection speed is fast, the precision is high, simple structure, easy and simple to handle's characteristics.
Drawings
FIG. 1 is a perspective view of a full-automatic chemiluminescence immunoassay of one embodiment;
FIG. 2 is a schematic diagram of the structure of a full-automatic chemiluminescence immunoassay according to an embodiment;
fig. 3 is a schematic structural view of a sample reagent disk according to an embodiment.
Detailed Description
A full-automatic chemiluminescence immunoassay will be described in further detail with reference to the embodiments and the drawings.
Referring to fig. 1 and 2, a full-automatic chemiluminescence immunoassay apparatus 100 of an embodiment includes: a frame 1, an analysis unit 2 provided on the frame 1, and a control unit (not shown) for controlling the operation of the analysis unit 2, the control unit being configured to control the analysis unit 2 to perform full-automatic chemiluminescence immunoassay. Specifically, the analysis section 2 includes: a sampling system 10, a sample reagent tray 20, a wash tank 30, an incubation wash system 40, a cuvette loading system 50, a cuvette handling system 60, an optical detection system 70, and a barcode scanning system 80. In an embodiment, the front end of the stand 1 is further provided with a touch screen control system (not shown) for controlling the operation of the whole system. The sampling system 10, the sample reagent tray 20, the washing tank 30, the incubation washing system 40, the cuvette loading system 50, the cuvette transfer system 60, the optical detection system 70, and the barcode scanning system 80 are all electrically connected to the control section.
In one embodiment, sampling system 10 is secured to frame 1, and sampling system 10 includes a sampling drive assembly 110, a sampling arm 120 coupled to drive assembly 110, and a sampling needle 130 disposed at one end of sampling arm 120. The sampling drive assembly 110 drives the sampling arm 120 to move the sampling needle 130, and the sampling needle 130 draws the sample or reagent from the sample reagent disk 20 and then discharges the sample or reagent into a cuvette in the incubation and cleaning system 40.
Specifically, in one embodiment, the sampling needle 130 is a rotary sampling needle, and is driven to rotate in a horizontal direction and move up and down in a vertical direction by the sampling driving assembly 110, the sampling needle 130 rotates and moves horizontally from an original position and moves down to a position where a sample suction port of the sample reagent tray 20 is located to suck up a sample or a reagent, then moves up and rotates horizontally to a position where a reaction cup in the incubation and washing system 40 is located, and discharges the sample or the reagent into the reaction cup.
Specifically, in another embodiment, the sampling needle 130 is a linear sampling needle, and the sampling needle 130 is driven to move horizontally and vertically up and down by the sampling driving assembly 110, and the sampling needle 130 is moved horizontally and downwardly from the original position to the position of the sample suction port of the sample reagent tray 20 to suck the sample or reagent, then moves upwardly and horizontally to the position of the cuvette in the incubation and washing system 40, and discharges the sample or reagent into the cuvette.
Referring to FIG. 3, in one embodiment, the sample reagent disk 20 includes a drive assembly 210 and a disk 220. The drive assembly 210 is used to drive the rotation of the disk 220 to transport the sample tube and reagent tube to the sampling site of the sampling needle 130. In one embodiment, the sample reagent tray 20 further includes an outer pot 230 disposed at the outer periphery of the tray 220, which can cool the reagent cartridge and the sample tube carried on the tray 220, and the outer pot 230 is fixed to the rack 1, and the outer pot 230 does not rotate with the rotation of the tray 220. In other embodiments, the outer pot 230 may not be provided, but instead, a housing may be employed. The tray 220 is approximately circular, cavities 222 for carrying the reagent kit and the sample tube are distributed along the circumferential direction of the tray 220, a cover 223 is arranged at the top of the tray 220 to prevent dust from falling into the reagent kit and the sample tube, through holes are formed in the cover 223 at the top to form a sample suction port 224, and the sampling needle 130 can pass through the sample suction port 224 to suck the reagent or sample in the reagent kit and the sample tube. The sample and the reagent are carried in the same tray 220 and driven by one driving mechanism, and compared with an independent sample tray and an independent reagent tray mechanism, the structure is simpler, the volume is smaller, and the cost is lower; the transfer of the sample and the reagent can be completed simultaneously by only one driving mechanism, the driving is simple, and the reliability is higher. In one embodiment, the cavity 222 has a plurality of receiving cavities in which a plurality of sample tubes and reagent tubes are received. In particular, the plurality of kits and the plurality of sample tubes are distributed on the tray 220 in a continuous or intermittent manner in spaced or zoned fashion, although other distributions of kits and sample tubes are possible in other embodiments. Correspondingly, the shape of the sample suction port 224 is arranged corresponding to the arrangement shape of the reagent cartridge and the sample tube. In this embodiment, the reagent kits and the sample tubes are distributed radially, and 3 reagent kits or sample tubes are distributed on one radial line, and then three holes corresponding to 3 reagent kits or sample tubes are formed on the sample suction port 224. In other embodiments, the number of the kits or the sample tubes may be 2, 4, 5, etc., and the specific number and manner of arrangement may be adjusted according to the actual situation.
The wash tank 30 is set on the sampled motion trajectory of the sampling needle 130. After the sampling needle 130 sucks the sample from the sample reagent tray 20 or discharges the sample into the cuvette again, the sample moves to the cleaning bath 30 along the movement path of the sample, descends into the cleaning liquid in the cleaning bath 30, and then performs the next sampling operation.
Incubation and wash system 40 includes incubation tray 410 and wash tray 420 arranged in concentric circles. The incubation plate 410 is disposed on the outer concentric circle, the washing plate 420 is disposed on the inner concentric circle, and the incubation plate 410 and the washing plate 420 are independently driven. By concentric design of the incubation plate 410 and the washing plate 420, the device is more compact in structure, smaller in size and lighter in weight under the function of realizing independent movement of the incubation plate 410 and the washing plate 420 by coaxial and independent driving. In one embodiment, the incubation tray 410 includes an incubation tray 412 for incubating samples in the reaction cup, an incubation driving assembly 414 for driving the incubation tray 412 to operate, and a heating assembly (not shown) for controlling the temperature of the incubation tray 410 and the cleaning tray 420, and a sample loading hole 4122, a first operation position 4124, and a second operation position 4126 are formed on top of the incubation tray 412. In an embodiment, the cleaning disc 420 is provided with a liquid injection mixing assembly 422, a liquid absorbing assembly 424 and a cleaning disc driving assembly 426 along the circumferential direction, wherein the liquid injection mixing assembly 422 is used for injecting cleaning liquid into the reaction cup and mixing samples in the reaction cup after incubation of the incubation disc 412, and the liquid absorbing assembly 424 is used for absorbing liquid after solid-liquid separation in the reaction cup. The cleaning disk 420 is used for multi-stage cleaning of the magnetic particles in the reaction cup. Specifically, the reaction cup is transferred to the cleaning tray 420, the movement of the reaction cup cleaning tray 420 is controlled by the control part, the reaction cup is transferred to the lower part of the liquid injection mixing assembly 422, the liquid injection mixing assembly 422 descends, the reaction cup is injected with and uniformly mixed with cleaning liquid, and after the uniform mixing is finished, the liquid injection mixing assembly 422 ascends and lifts up. The cleaning disk driving component 426 controls the cleaning disk 420 to move, transfers the reaction cup to an adsorption area with a magnet, and controls the liquid absorbing component 424 to descend to absorb the liquid in the reaction cup after adsorbing the magnetic particles in the liquid in the reaction cup for a period of time so as to achieve the purpose of cleaning the magnetic particles in the reaction cup. Multiple cleaning steps are completed through multiple liquid injection, adsorption and liquid suction, and multi-stage cleaning is realized. In one embodiment, the injection mixing assembly 422 has a plurality of injection needles, the pipetting assembly 424 has a plurality of pipetting needles, and the injection needles and the pipetting needles may be driven independently or jointly, preferably independently. The liquid injection needles and the liquid suction needles can simultaneously realize the injection and the liquid suction of the cleaning liquid of the reaction cups.
The cuvette loading system 50 includes a guide rail 510 that is arranged obliquely, and a cuvette carrier structure 520 that is positioned on the guide rail 510. The rail 510 is located on one side of the sample reagent disk 20 and incubation and cleaning system 40, and the rail 510 is responsible for the storage and loading functions of the cuvette, which is manually loaded onto the rail 510 by a user.
The cuvette transfer system 60 is coupled to the cuvette loading system 50 and includes a gripping mechanism 610 for gripping the cuvette, a liquid injection mechanism 620 (which may also be omitted) for injecting liquid into the cuvette, and a motion control system 630 for controlling the transfer of the cuvette between the incubation tray 410, the washing tray 420, and the cuvette loading system 50. During the transfer of the cuvette, the motion control system 630 may control the liquid injection mechanism 620 to inject liquid into the cuvette and rotate the cuvette to mix the liquid in the cuvette. In one embodiment, the gripping mechanism 610 includes a gripping arm 612 disposed on the frame 1 and a gripper (not shown) disposed at one end of the gripping arm 612 for gripping the cuvette. In other embodiments, the gripping mechanism 610 may have other configurations, and is not limited only herein.
An optical detection system 70 is coupled to the outside of incubation and washing system 40 and includes an optical counting device for reading the detection result signal.
A barcode scanning system 80 is located on the outside of the sample reagent tray and includes a scanner (not shown) for scanning the sample tube barcode and the kit barcode information. In one embodiment, a bar code card slot is provided in the optical path intermediate the scanner and the sample reagent disk 20. Specifically, in this embodiment, the card slot is a slit, and the scanner can scan the card with bar code inserted into the slot by the operator.
In this embodiment, the workflow of the above-described full-automatic chemiluminescence immunoassay analyzer 100 is as follows:
the full-automatic chemiluminescence immunoassay analyzer 100 is started, and the whole analysis flow starts: the sampling needle 130 is controlled to move to a sample sucking port 224 in the sample reagent disk 20 by the sampling driving assembly 110, the system is driven by the driving assembly 210 of the sample reagent disk 20, the sample tube is controlled to rotate to the position of the sample sucking port 224, the sampling needle 130 descends to suck the sample, then ascends to rotate, moves to a sample adding hole 4122 of the incubation and cleaning system 40, and discharges the sample into a reaction cup in the incubation and cleaning system 40, and then the sampling needle 130 is controlled to move to a cleaning pool 30 for cleaning for the next sampling;
the sampling needle 130 is controlled to move to a sample sucking port 224 in the sample reagent disk 20 through the sampling driving assembly 110, the system is driven through the driving assembly 210 of the sample reagent disk 20, the reagent box is controlled to rotate to the sample sucking port, the sampling needle 130 descends to suck the reagent, the reagent is moved to a sample adding hole 4122 of the incubation and cleaning system 40, the reagent is discharged into a reaction cup in the incubation and cleaning system 40, and then the sampling needle 130 is controlled to move to a cleaning pool 30 for cleaning for the next sampling;
an incubation driving assembly 414 in the incubation cleaning system 40 controls the incubation tray 412 to move, and the incubation driving assembly heats the reaction cups in the incubation tray 412;
after incubation, the incubation driving assembly 414 controls the reaction cup to move to the first operation position 4124, the reaction cup transferring system 60 controls the reaction cup gripper to move to the first operation position 4124, the reaction cup is grabbed in a descending manner, and controls the reaction cup gripper to move to the second operation position 4126, and the reaction cup is put in a descending manner;
the reaction cup is transported to the cleaning disc 420, the cleaning disc driving component 426 of the cleaning disc controls the cleaning disc 420 to move, the reaction cup is transported to the lower part of the liquid injection mixing component 422, the liquid injection mixing component 422 descends, the reaction cup is injected with cleaning liquid and uniformly mixed, and after the mixing is finished, the liquid injection mixing component 422 ascends and lifts up. The cleaning disc 420 continues to move, the reaction cup is transported to the adsorption area with the magnet, after the magnetic particles in the liquid in the reaction cup are adsorbed for a period of time, the liquid sucking component 424 is controlled to descend to suck the liquid in the reaction cup, so that the purpose of cleaning the magnetic particles in the reaction cup is achieved. Multiple cleaning steps are completed through multiple liquid injection, adsorption and liquid suction, and multi-stage cleaning is realized;
after the cleaning is completed, the cleaning disk drive assembly 426 controls the movement of the cuvette to the second operational position 4126 and the cuvette transfer system 60 transfers the cleaned cuvette to the first operational position 4124 of the incubation cleaning system 40; in the process of transferring the reaction cup, the liquid injection mechanism 620 on the reaction cup transferring system 60 injects liquid into the reaction cup, rotates the reaction cup, and mixes the liquid in the reaction cup uniformly;
after the reaction cups are transferred to the incubation tray 410 of the incubation and cleaning system 40, the heating assembly heats and incubates the liquid in the reaction cups; after incubation heating is completed, the incubation driving assembly 414 controls the incubation tray to move, the reaction cup is transferred to the light measuring position, the optical detection system 70 detects the reaction cup at the light measuring position, and signals are read through the optical counting device, so that a measurement result is obtained, and the whole measurement process is completed.
In the full-automatic chemiluminescence immunoassay analyzer, the sample and the reagent are carried in one sample reagent tray and driven by one driving mechanism, and compared with an independent sample tray and an independent reagent tray mechanism, the full-automatic chemiluminescence immunoassay analyzer has the advantages of simpler structure, smaller volume and lower cost; and the transfer of the sample and the reagent can be completed simultaneously by using one driving mechanism, so that the driving is simple and the reliability is higher; in addition, through the concentric design of incubation dish and washing dish, coaxial but independent drive realizes the function of each independent motion down, and the structure is compacter, and the instrument volume is littleer, light in weight. Through the design of complete machine overall arrangement and the integrated design of functional module, above-mentioned full automatization chemiluminescence immunoassay appearance has small, degree of automation is high, detection speed is fast, the precision is high, simple structure, easy and simple to handle's characteristics.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. A full-automatic chemiluminescence immunoassay analyzer, comprising: a frame, an analysis part arranged on the frame and a control part for controlling the operation of the analysis part; the analysis unit includes:
the sampling system comprises a sampling driving assembly, a sampling arm connected with the sampling driving assembly and a sampling needle arranged at one end of the sampling arm;
a sample reagent tray for storing and dispensing the reagent kit and the sample tube;
the cleaning pool is arranged on the motion trail of the sampling needle for sampling and is used for cleaning the sampling needle;
the incubation cleaning system comprises an incubation tray and a cleaning tray, wherein the incubation tray and the cleaning tray are arranged in concentric circles, the incubation tray is arranged on an outer ring, the cleaning tray is arranged on an inner ring, the incubation tray and the cleaning tray are independently driven, the incubation tray comprises an incubation tray body for incubating samples in a reaction cup, an incubation driving assembly for driving the incubation tray body to operate, and a heating assembly for controlling the temperature of the incubation tray and the cleaning tray, the cleaning tray is used for carrying out multistage cleaning on magnetic particles in the reaction cup, an injection liquid mixing assembly and a liquid absorbing assembly positioned on one side of the injection liquid mixing assembly are arranged on the cleaning tray along the circumferential direction, a cleaning tray driving assembly for driving the cleaning tray is arranged on the side of the cleaning tray, and the injection liquid mixing assembly is used for injecting cleaning liquid into the reaction cup and uniformly mixing the samples in the reaction cup after incubation of the incubation tray body, and the liquid absorbing assembly is used for absorbing liquid after solid-liquid separation in the reaction cup;
the reaction cup loading system is used for loading the reaction cup;
the reaction cup transfer system is connected with the reaction cup loading system and comprises a grabbing mechanism for grabbing the reaction cup and a motion control system for controlling the reaction cup to transfer among the incubation plate, the cleaning plate and the reaction cup loading system;
the optical detection system is connected to the outer side of the incubation disc and comprises an optical counting device for reading detection result signals;
the control part is electrically connected with the sampling system, the sample reagent disk, the cleaning pool, the incubation cleaning system, the reaction cup loading system, the reaction cup transferring system and the optical detection system.
2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, further comprising a bar code scanning system located outside the sample reagent tray, the bar code scanning system comprising a scanner for scanning sample tube bar codes and kit bar code information, a bar code card slot being provided on an optical path between the scanner and the sample reagent tray.
3. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the liquid injection mixing assembly is provided with a plurality of liquid injection needles, and the liquid absorbing assembly is provided with a plurality of liquid absorbing needles.
4. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the cuvette loading system comprises a guide rail arranged obliquely and a cuvette carrying structure positioned on the guide rail.
5. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the sample reagent tray comprises a drive assembly and a tray body, the drive assembly for driving the tray body to rotate; the tray body is distributed with the cavity that bears kit and sample pipe along circumferencial direction, the tray body top is equipped with inhales the appearance mouth, the sampling needle motion extremely inhale the sample in the reagent and the sample pipe in the kit of appearance mouth.
6. The full-automatic chemiluminescence immunoassay analyzer of claim 5, wherein a plurality of the kits and a plurality of the sample tubes are distributed on the tray.
7. The full-automatic chemiluminescence immunoassay analyzer of claim 5, wherein the sample reagent tray comprises an outer pot surrounding the tray body and capable of refrigerating the reagent kit and sample tube carried on the tray body.
8. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the sampling needle is a rotary sampling needle, and the sampling drive assembly drives rotation in a horizontal direction and movement in a vertical direction to aspirate a sample or reagent and expel the sample or reagent into a reaction cup.
9. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the sampling needle is a linear sampling needle, and the sample or reagent is aspirated by the sample driving assembly driving translation in a horizontal direction and movement in a vertical direction, and is discharged into the reaction cup.
10. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the cuvette transfer system comprises a liquid injection mechanism for injecting liquid into the cuvette.
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| CN110376367A (en) * | 2019-07-12 | 2019-10-25 | 上海子舜实业有限公司 | A kind of chemiluminescence cleaning incubation design |
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| CN113567691A (en) * | 2020-04-28 | 2021-10-29 | 深圳迎凯生物科技有限公司 | Incubation device and automatic analysis device |
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| CN113504380A (en) * | 2021-06-15 | 2021-10-15 | 复星诊断科技(上海)有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN114295850A (en) * | 2021-12-31 | 2022-04-08 | 沈阳医陆生物科技有限公司 | Sample detection system, sample detection method and kit preparation method |
| CN114113052A (en) * | 2022-01-27 | 2022-03-01 | 广州科方生物技术股份有限公司 | Multifunctional chemiluminescence analysis device |
| CN114167048A (en) * | 2022-02-07 | 2022-03-11 | 宁波奥丞生物科技有限公司 | Integrated system for reagent incubation reaction |
| CN114384063A (en) * | 2022-03-23 | 2022-04-22 | 深圳天辰医疗科技有限公司 | Chemiluminescence apparatus |
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